Baker Bros. Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Abeona Therapeutics Inc.	COM	00289Y107	4,637	1,590,686	SH		SOLE		1,590,686	0	0
ACADIA Pharmaceuticals Inc.	COM	004225108	2,031,115	41,904,586	SH		SOLE		41,904,586	0	0
Acceleron Pharma Inc.	COM	00434H108	2,572	27,000	SH		SOLE		27,000	0	0
Adamas Pharmaceuticals, Inc.	COM	00548A106	442	172,630	SH		SOLE		172,630	0	0
Adaptive Biotechnologies Corporation	COM	00650F109	22,426	463,539	SH		SOLE		463,539	0	0
Adaptimmune Therapeutics plc	SPONSORED ADR	00653A107	66,819	6,675,181	SH		SOLE		6,675,181	0	0
ADC Therapeutics SA	SHS	H0036K147	78,992	1,687,500	SH		SOLE		1,687,500	0	0
Aeglea BioTherapeutics, Inc.	COM	00773J103	40,511	4,379,592	SH		SOLE		4,379,592	0	0
Affimed N.V.	COM	N01045108	923	200,000	SH		SOLE		200,000	0	0
Aimmune Therapeutics, Inc.	COM	00900T107	11,261	673,908	SH		SOLE		673,908	0	0
Albireo Pharma, Inc.	COM	01345P106	9,776	369,047	SH		SOLE		369,047	0	0
Alector, Inc.	COM	014442107	6,843	280,000	SH		SOLE		280,000	0	0
Alexion Pharmaceuticals, Inc.	COM	015351109	983,312	8,760,794	SH		SOLE		8,760,794	0	0
Alkermes plc	SHS	G01767105	24,154	1,244,744	SH		SOLE		1,244,744	0	0
Allakos Inc.	COM	01671P100	52,851	735,469	SH		SOLE		735,469	0	0
Altimmune, Inc.	COM	02155H200	22,572	2,107,600	SH		SOLE		2,107,600	0	0
Amarin Corporation plc	SPONSORED ADR	023111206	238,717	34,496,685	SH		SOLE		34,496,685	0	0
AnaptysBio, Inc.	COM	032724106	11,476	513,677	SH		SOLE		513,677	0	0
Apellis Pharmaceuticals, Inc.	COM	03753U106	29,281	896,551	SH		SOLE		896,551	0	0
Applied Therapeutics, Inc.	COM	03828A101	2,384	65,934	SH		SOLE		65,934	0	0
Aravive, Inc.	COM	03890D108	2,841	244,055	SH		SOLE		244,055	0	0
Arcus Biosciences, Inc.	COM	03969F109	3,007	121,534	SH		SOLE		121,534	0	0
argenx SE	SPONSORED ADR	04016X101	229,635	1,019,557	SH		SOLE		1,019,557	0	0
ARYA Sciences Acquisition Corp.	SHS CL A	G3165V109	2,361	150,000	SH		SOLE		150,000	0	0
Ascendis Pharma A/S	SPONSORED ADR	04351P101	501,421	3,390,270	SH		SOLE		3,390,270	0	0
Assembly Biosciences, Inc.	COM	045396108	35,951	1,541,618	SH		SOLE		1,541,618	0	0
Atreca, Inc.	CL A COM	04965G109	75,177	3,532,760	SH		SOLE		3,532,760	0	0
Aurinia Pharmaceuticals Inc.	COM	05156V102	27,656	1,701,929	SH		SOLE		1,701,929	0	0
Autolus Therapeutics plc	SPON ADS	05280R100	7,785	485,624	SH		SOLE		485,624	0	0
Axsome Therapeutics, Inc.	COM	05464T104	83,083	1,009,757	SH		SOLE		1,009,757	0	0
BeiGene, Ltd.	SPONSORED ADR	07725L102	2,218,840	11,777,285	SH		SOLE		11,777,285	0	0
Bellicum Pharmaceuticals, Inc.	COM	079481404	1,851	249,123	SH		SOLE		249,123	0	0
BioCryst Pharmaceuticals, Inc.	COM	09058V103	65,597	13,766,405	SH		SOLE		13,766,405	0	0
BioMarin Pharmaceutical Inc.	COM	09061G101	936,064	7,589,294	SH		SOLE		7,589,294	0	0
bluebird bio, Inc.	COM	09609G100	16,176	265,000	SH		SOLE		265,000	0	0
Burning Rock Biotech Limited	SPONSORED ADS	12233L107	6,753	250,000	SH		SOLE		250,000	0	0
Cabaletta Bio, Inc.	COM	12674W109	7,089	636,363	SH		SOLE		636,363	0	0
Catalyst Pharmaceuticals, Inc.	COM	14888U101	2,310	500,000	SH		SOLE		500,000	0	0
Cerus Corporation	COM	157085101	90,507	13,713,195	SH		SOLE		13,713,195	0	0
ChemoCentryx, Inc.	COM	16383L106	54,388	945,221	SH		SOLE		945,221	0	0
Chiasma, Inc.	COM	16706W102	5,093	946,701	SH		SOLE		946,701	0	0
Constellation Pharmaceuticals, Inc.	COM	210373106	4,007	133,333	SH		SOLE		133,333	0	0
Crinetics Pharmaceuticals, Inc.	COM	22663K107	5,569	317,857	SH		SOLE		317,857	0	0
CymaBay Therapeutics, Inc.	COM	23257D103	5,315	1,522,792	SH		SOLE		1,522,792	0	0
DBV Technologies S.A.	SPONSORED ADR	23306J101	64,157	14,614,264	SH		SOLE		14,614,264	0	0
Denali Therapeutics Inc.	COM	24823R105	2,536	104,900	SH		SOLE		104,900	0	0
Dicerna Pharmaceuticals, Inc.	COM	253031108	3,031	119,335	SH		SOLE		119,335	0	0
Exact Sciences Corporation	COM	30063P105	160,503	1,846,139	SH		SOLE		1,846,139	0	0
Evofem Biosciences, Inc.	COM	30048L104	4,033	1,425,000	SH		SOLE		1,425,000	0	0
Frequency Therapeutics, Inc.	COM	35803L108	21,988	945,719	SH		SOLE		945,719	0	0
Forma Therapeutics Holdings, Inc.	SHS	34633R104	92,980	2,000,000	SH		SOLE		2,000,000	0	0
Fulgent Genetics, Inc.	COM	359664109	9,111	569,444	SH		SOLE		569,444	0	0
Galapagos NV	SPON ADR	36315X101	2,579	13,072	SH		SOLE		13,072	0	0
Galmed Pharmaceuticals Ltd.	SHS	M47238106	1,031	215,594	SH		SOLE		215,594	0	0
Gamida Cell Ltd.	SHS	M47364100	3,047	666,666	SH		SOLE		666,666	0	0
Genfit SA	ADS	372279109	156	28,396	SH		SOLE		28,396	0	0
Global Blood Therapeutics, Inc.	COM	37890U108	2,967	47,000	SH		SOLE		47,000	0	0
GW Pharmaceuticals plc	ADS	36197T103	22,709	185,045	SH		SOLE		185,045	0	0
Heron Therapeutics, Inc.	COM	427746102	88,526	6,018,104	SH		SOLE		6,018,104	0	0
HOOKIPA Pharma Inc.	COM	43906K100	8,140	700,481	SH		SOLE		700,481	0	0
Horizon Therapeutics Public Ltd Co	SHS	G46188101	11,116	200,000	SH		SOLE		200,000	0	0
Idera Pharmaceuticals, Inc.	COM PAR	45168K405	8,250	4,608,786	SH		SOLE		4,608,786	0	0
IGM Biosciences, Inc.	COM	449585108	229,528	3,144,223	SH		SOLE		3,144,223	0	0
Immunomedics, Inc.	COM	452907108	11,695	330,000	SH		SOLE		330,000	0	0
Incyte Corporation	COM	45337C102	3,326,944	31,999,081	SH		SOLE		31,999,081	0	0
Infinity Pharmaceuticals, Inc.	COM	45665G303	525	580,400	SH		SOLE		580,400	0	0
Inflarx N.V.	COM	N44821101	4,859	1,058,555	SH		SOLE		1,058,555	0	0
Insmed Incorporated	COM PAR $.01	457669307	83,319	3,025,384	SH		SOLE		3,025,384	0	0
Intellia Therapeutics, Inc.	COM	45826J105	2,702	128,538	SH		SOLE		128,538	0	0
Invitae Corporation	COM	46185L103	358,966	11,850,962	SH		SOLE		11,850,962	0	0
IVERIC bio, Inc.	COM	46583P102	8,341	1,635,501	SH		SOLE		1,635,501	0	0
Karuna Therapeutics, Inc.	COM	48576A100	9,137	81,976	SH		SOLE		81,976	0	0
Kezar Life Sciences, Inc.	COM	49372L100	3,108	600,000	SH		SOLE		600,000	0	0
Kiniksa Pharmaceuticals, Ltd.	COM CL A	G5269C101	71,333	2,799,577	SH		SOLE		2,799,577	0	0
Kodiak Sciences Inc.	COM	50015M109	626,414	11,574,538	SH		SOLE		11,574,538	0	0
Krystal Biotech, Inc.	COM	501147102	33,866	817,631	SH		SOLE		817,631	0	0
Leap Therapeutics, Inc.	COM	52187K101	2,045	978,454	SH		SOLE		978,454	0	0
Legend Biotech Corporation	SPONSORED ADS	52490G102	5,746	135,000	SH		SOLE		135,000	0	0
Madrigal Pharmaceuticals, Inc.	COM	558868105	169,786	1,499,212	SH		SOLE		1,499,212	0	0
Marker Therapeutics, Inc.	COM	57055L107	498	240,505	SH		SOLE		240,505	0	0
Matinas BioPharma Holdings, Inc.	COM	576810105	1,620	2,096,375	SH		SOLE		2,096,375	0	0
Merus N.V.	COM	N5749R100	32,783	2,037,469	SH		SOLE		2,037,469	0	0
Mirati Therapeutics, Inc.	COM	60468T105	160,955	1,409,784	SH		SOLE		1,409,784	0	0
Mirum Pharmaceuticals, Inc.	COM	604749101	11,352	583,333	SH		SOLE		583,333	0	0
Molecular Templates, Inc.	COM	608550109	2,182	158,217	SH		SOLE		158,217	0	0
MyoKardia, Inc.	COM	62857M105	305,728	3,164,234	SH		SOLE		3,164,234	0	0
Neoleukin Therapeutics, Inc.	COM	64049K104	56,402	3,397,740	SH		SOLE		3,397,740	0	0
Neurocrine Biosciences, Inc.	COM	64125C109	110,652	906,986	SH		SOLE		906,986	0	0
NGM Biopharmaceuticals, Inc.	COM	62921N105	2,456	124,400	SH		SOLE		124,400	0	0
Novavax, Inc.	COM	670002401	20,119	241,376	SH		SOLE		241,376	0	0
Orchard Therapeutics plc	ADS	68570P101	2,434	405,702	SH		SOLE		405,702	0	0
Ovid Therapeutics Inc.	COM	690469101	3,377	458,253	SH		SOLE		458,253	0	0
Oyster Point Pharma, Inc.	COM	69242L106	2,063	71,428	SH		SOLE		71,428	0	0
Passage Bio, Inc.	COM	702712100	7,516	275,000	SH		SOLE		275,000	0	0
Principia Biopharma Inc.	COM	74257L108	94,520	1,580,873	SH		SOLE		1,580,873	0	0
Protagonist Therapeutics, Inc.	COM	74366E102	33,756	1,911,446	SH		SOLE		1,911,446	0	0
Protara Therapeutics, Inc.	COM STK	74365U107	5,854	199,671	SH		SOLE		199,671	0	0
Reata Pharmaceuticals, Inc.	CL A	75615P103	8,734	55,983	SH		SOLE		55,983	0	0
Replimune Group, Inc.	COM	76029N106	128	5,141	SH		SOLE		5,141	0	0
Rhythm Pharmaceuticals, Inc.	COM	76243J105	60,211	2,700,055	SH		SOLE		2,700,055	0	0
Sangamo Therapeutics, Inc.	COM	800677106	8,958	999,823	SH		SOLE		999,823	0	0
Seattle Genetics, Inc.	COM	812578102	8,032,021	47,269,424	SH		SOLE		47,269,424	0	0
Sunesis Pharmaceuticals, Inc.	COM	867328700	147	556,665	SH		SOLE		556,665	0	0
Syros Pharmaceuticals, Inc.	COM	87184Q107	7,357	690,167	SH		SOLE		690,167	0	0
Tricida, Inc.	COM	89610F101	21,643	787,582	SH		SOLE		787,582	0	0
uniQure N.V.	SHS	N90064101	10,404	230,883	SH		SOLE		230,883	0	0
Urovant Sciences Ltd.	SHS	G9381B108	9,840	1,000,000	SH		SOLE		1,000,000	0	0
Vaxart, Inc.	COM	92243A200	14,506	1,639,121	SH		SOLE		1,639,121	0	0
Viking Therapeutics, Inc.	COM	92686J106	3,064	425,000	SH		SOLE		425,000	0	0
Xencor, Inc.	COM	98401F105	13,867	428,120	SH		SOLE		428,120	0	0
Xenon Pharmaceuticals Inc.	COM	98420N105	10,021	799,102	SH		SOLE		799,102	0	0
Zymeworks Inc.	COM	98985W102	61,625	1,708,472	SH		SOLE		1,708,472	0	0
BioMarin Pharmaceutical Inc.	NOTE 0.599% 8/1/2024	09061GAH4	18,340	15,000,000	PRN		SOLE		15,000,000	0	0
Neurocrine Biosciences, Inc.	NOTE 2.25% 5/15/2024	64125CAD1	51,144	30,770,000	PRN		SOLE		30,770,000	0	0