Baker Bros. Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ACADIA Pharmaceuticals Inc.	COM	004225108	1,728,564	41,904,586	SH		SOLE		41,904,586	0	0
Acceleron Pharma Inc.	COM	00434H108	2,885	25,640	SH		SOLE		25,640	0	0
Adamas Pharmaceuticals, Inc.	COM	00548A106	675	163,830	SH		SOLE		163,830	0	0
Adaptive Biotechnologies Corporation	COM	00650F109	21,423	440,539	SH		SOLE		440,539	0	0
Adaptimmune Therapeutics plc	SPONSORED ADR	00653A107	50,516	6,330,354	SH		SOLE		6,330,354	0	0
ADC Therapeutics SA	SHS	H0036K147	55,671	1,687,500	SH		SOLE		1,687,500	0	0
Aeglea BioTherapeutics, Inc.	COM	00773J103	31,051	4,379,592	SH		SOLE		4,379,592	0	0
Affimed N.V.	COM	N01045108	643	189,800	SH		SOLE		189,800	0	0
Akero Therapeutics, Inc.	COM	00973Y108	4,058	131,788	SH		SOLE		131,788	0	0
Albireo Pharma, Inc.	COM	01345P106	18,322	549,047	SH		SOLE		549,047	0	0
Alector, Inc.	COM	014442107	2,798	265,600	SH		SOLE		265,600	0	0
Alexion Pharmaceuticals, Inc.	COM	015351109	1,002,498	8,760,794	SH		SOLE		8,760,794	0	0
Alkermes plc	SHS	G01767105	22,519	1,359,001	SH		SOLE		1,359,001	0	0
Allakos Inc.	COM	01671P100	56,890	698,469	SH		SOLE		698,469	0	0
Altimmune, Inc.	COM	02155H200	29,132	2,206,955	SH		SOLE		2,206,955	0	0
Amarin Corporation plc	SPONSORED ADR	023111206	134,799	32,018,867	SH		SOLE		32,018,867	0	0
AnaptysBio, Inc.	COM	032724106	7,187	487,243	SH		SOLE		487,243	0	0
Apellis Pharmaceuticals, Inc.	COM	03753U106	27,049	896,551	SH		SOLE		896,551	0	0
Applied Therapeutics, Inc.	COM	03828A101	790	38,034	SH		SOLE		38,034	0	0
Aravive, Inc.	COM	03890D108	357	75,854	SH		SOLE		75,854	0	0
Arcus Biosciences, Inc.	COM	03969F109	1,978	115,425	SH		SOLE		115,425	0	0
argenx SE	SPONSORED ADR	04016X101	267,654	1,019,557	SH		SOLE		1,019,557	0	0
Ascendis Pharma A/S	SPONSORED ADR	04351P101	546,334	3,540,270	SH		SOLE		3,540,270	0	0
Assembly Biosciences, Inc.	COM	045396108	25,341	1,541,418	SH		SOLE		1,541,418	0	0
Athira Pharma, Inc.	COM	04746L104	16,288	882,352	SH		SOLE		882,352	0	0
Atreca, Inc.	CL A COM	04965G109	49,353	3,532,760	SH		SOLE		3,532,760	0	0
Aurinia Pharmaceuticals Inc.	COM	05156V102	23,834	1,618,029	SH		SOLE		1,618,029	0	0
Autolus Therapeutics plc	SPONSORED ADS	05280R100	5,370	461,324	SH		SOLE		461,324	0	0
Axsome Therapeutics, Inc.	COM	05464T104	68,383	959,757	SH		SOLE		959,757	0	0
BeiGene, Ltd.	SPONSORED ADR	07725L102	3,810,109	13,301,597	SH		SOLE		13,301,597	0	0
Bellicum Pharmaceuticals, Inc.	COM	079481404	1,637	249,123	SH		SOLE		249,123	0	0
BioCryst Pharmaceuticals, Inc.	COM	09058V103	43,610	12,695,818	SH		SOLE		12,695,818	0	0
BioMarin Pharmaceutical Inc.	COM	09061G101	577,393	7,589,294	SH		SOLE		7,589,294	0	0
bluebird bio, Inc.	COM	09609G100	13,595	252,000	SH		SOLE		252,000	0	0
Burning Rock Biotech Limited	SPONSORED ADS	12233L107	5,951	237,300	SH		SOLE		237,300	0	0
Cabaletta Bio, Inc.	COM	12674W109	6,898	636,363	SH		SOLE		636,363	0	0
Catalyst Pharmaceuticals, Inc.	COM	14888U101	1,409	474,400	SH		SOLE		474,400	0	0
Cerus Corporation	COM	157085101	85,845	13,713,195	SH		SOLE		13,713,195	0	0
ChemoCentryx, Inc.	COM	16383L106	49,310	899,821	SH		SOLE		899,821	0	0
Chiasma, Inc.	COM	16706W102	3,191	742,133	SH		SOLE		742,133	0	0
Constellation Pharmaceuticals, Inc.	COM	210373106	2,701	133,333	SH		SOLE		133,333	0	0
Crinetics Pharmaceuticals, Inc.	COM	22663K107	4,737	302,320	SH		SOLE		302,320	0	0
Cymabay Therapeutics, Inc.	COM	23257D103	23,548	3,252,542	SH		SOLE		3,252,542	0	0
DBV Technologies S.A.	SPONSORED ADR	23306J101	25,283	14,614,264	SH		SOLE		14,614,264	0	0
Denali Therapeutics Inc.	COM	24823R105	3,562	99,400	SH		SOLE		99,400	0	0
Dicerna Pharmaceuticals, Inc.	COM	253031108	2,035	113,135	SH		SOLE		113,135	0	0
Exact Sciences Corporation	COM	30063P105	188,214	1,846,139	SH		SOLE		1,846,139	0	0
Evofem Biosciences, Inc.	COM	30048L104	1,022	433,048	SH		SOLE		433,048	0	0
Frequency Therapeutics, Inc.	COM	35803L108	18,241	949,555	SH		SOLE		949,555	0	0
Forma Therapeutics Holdings, Inc.	SHS	34633R104	88,292	1,771,509	SH		SOLE		1,771,509	0	0
Fulgent Genetics, Inc.	COM	359664109	21,869	546,189	SH		SOLE		546,189	0	0
Galapagos NV	SPONSORED ADR	36315X101	1,761	12,412	SH		SOLE		12,412	0	0
Galmed Pharmaceuticals Ltd.	SHS	M47238106	725	205,375	SH		SOLE		205,375	0	0
Gamida Cell Ltd.	SHS	M47364100	2,628	633,324	SH		SOLE		633,324	0	0
Genetron Holdings Limited	ADS	37186H100	1,194	100,000	SH		SOLE		100,000	0	0
Genfit SA	ADS	372279109	150	28,396	SH		SOLE		28,396	0	0
Global Blood Therapeutics, Inc.	COM	37890U108	50,749	920,375	SH		SOLE		920,375	0	0
GW Pharmaceuticals plc	ADS	36197T103	13,507	138,745	SH		SOLE		138,745	0	0
Harmony Biosciences Holdings, Inc.	COM	413197104	13,560	400,000	SH		SOLE		400,000	0	0
Heron Therapeutics, Inc.	COM	427746102	88,842	5,994,704	SH		SOLE		5,994,704	0	0
HOOKIPA Pharma Inc.	COM	43906K100	6,634	700,481	SH		SOLE		700,481	0	0
Horizon Therapeutics Public Ltd Co	SHS	G46188101	51,774	666,500	SH		SOLE		666,500	0	0
Idera Pharmaceuticals, Inc.	COM PAR	45168K405	9,863	4,608,786	SH		SOLE		4,608,786	0	0
IGM Biosciences, Inc.	COM	449585108	232,092	3,144,446	SH		SOLE		3,144,446	0	0
Immatics N.V.	SHS	N44445109	10,625	1,001,414	SH		SOLE		1,001,414	0	0
Immunomedics, Inc.	COM	452907108	20,211	237,694	SH		SOLE		237,694	0	0
Incyte Corporation	COM	45337C102	2,871,626	31,999,398	SH		SOLE		31,999,398	0	0
Infinity Pharmaceuticals, Inc.	COM	45665G303	679	580,400	SH		SOLE		580,400	0	0
Inflarx N.V.	COM	N44821101	4,292	1,007,559	SH		SOLE		1,007,559	0	0
Inozyme Pharma, Inc.	COM	45790W108	3,115	118,500	SH		SOLE		118,500	0	0
Insmed Incorporated	COM PAR $.01	457669307	73,045	2,272,712	SH		SOLE		2,272,712	0	0
Intellia Therapeutics, Inc.	COM	45826J105	2,430	122,238	SH		SOLE		122,238	0	0
Invitae Corporation	COM	46185L103	513,739	11,850,962	SH		SOLE		11,850,962	0	0
Iteos Therapeutics, Inc.	COM	46565G104	4,134	167,562	SH		SOLE		167,562	0	0
IVERIC bio, Inc.	COM	46583P102	7,930	1,406,037	SH		SOLE		1,406,037	0	0
Karuna Therapeutics, Inc.	COM	48576A100	6,014	77,776	SH		SOLE		77,776	0	0
Kezar Life Sciences, Inc.	COM	49372L100	2,783	574,958	SH		SOLE		574,958	0	0
Kiniksa Pharmaceuticals, Ltd.	COM CL A	G5269C101	42,890	2,799,577	SH		SOLE		2,799,577	0	0
Kymera Therapeutics, Inc.	COM	501575104	63,302	1,959,211	SH		SOLE		1,959,211	0	0
Kodiak Sciences Inc.	COM	50015M109	731,372	12,352,175	SH		SOLE		12,352,175	0	0
Krystal Biotech, Inc.	COM	501147102	33,372	775,192	SH		SOLE		775,192	0	0
Leap Therapeutics, Inc.	COM	52187K101	1,108	559,705	SH		SOLE		559,705	0	0
Legend Biotech Corporation	SPONSORED ADS	52490G102	3,958	128,200	SH		SOLE		128,200	0	0
Madrigal Pharmaceuticals, Inc.	COM	558868105	178,002	1,499,213	SH		SOLE		1,499,213	0	0
Merus N.V.	COM	N5749R100	24,450	2,037,469	SH		SOLE		2,037,469	0	0
Mirati Therapeutics, Inc.	COM	60468T105	234,095	1,409,784	SH		SOLE		1,409,784	0	0
Mirum Pharmaceuticals, Inc.	COM	604749101	10,656	553,009	SH		SOLE		553,009	0	0
Molecular Templates, Inc.	COM	608550109	1,625	148,817	SH		SOLE		148,817	0	0
MyoKardia, Inc.	COM	62857M105	410,264	3,009,344	SH		SOLE		3,009,344	0	0
Neoleukin Therapeutics, Inc.	COM	64049K104	45,861	3,821,740	SH		SOLE		3,821,740	0	0
Neurocrine Biosciences, Inc.	COM	64125C109	65,098	676,975	SH		SOLE		676,975	0	0
NGM Biopharmaceuticals, Inc.	COM	62921N105	1,879	118,100	SH		SOLE		118,100	0	0
Novavax, Inc.	COM	670002401	20,302	187,376	SH		SOLE		187,376	0	0
Nurix Therapeutics, Inc.	COM	67080M103	62,451	1,788,921	SH		SOLE		1,788,921	0	0
Orchard Therapeutics plc	ADS	68570P101	1,411	343,202	SH		SOLE		343,202	0	0
Ovid Therapeutics Inc.	COM	690469101	3,391	590,761	SH		SOLE		590,761	0	0
Oyster Point Pharma, Inc.	COM	69242L106	1,440	68,228	SH		SOLE		68,228	0	0
Pacific Biosciences of California, Inc.	COM	69404D108	32,078	3,250,000	SH		SOLE		3,250,000	0	0
Passage Bio, Inc.	COM	702712100	3,423	261,066	SH		SOLE		261,066	0	0
Prelude Therapeutics Incorporated	COM	74065P101	304,875	10,118,636	SH		SOLE		10,118,636	0	0
Protagonist Therapeutics, Inc.	COM	74366E102	31,206	1,596,198	SH		SOLE		1,596,198	0	0
Protara Therapeutics, Inc.	COM STK	74365U107	3,360	199,671	SH		SOLE		199,671	0	0
Reata Pharmaceuticals, Inc.	CL A	75615P103	5,181	53,183	SH		SOLE		53,183	0	0
Replimune Group, Inc.	COM	76029N106	4,756	206,586	SH		SOLE		206,586	0	0
Rhythm Pharmaceuticals, Inc.	COM	76243J105	53,550	2,471,155	SH		SOLE		2,471,155	0	0
Sangamo Therapeutics, Inc.	COM	800677106	8,976	949,823	SH		SOLE		949,823	0	0
Seagen Inc.	COM	81181C104	9,250,154	47,269,424	SH		SOLE		47,269,424	0	0
Sunesis Pharmaceuticals, Inc.	COM PAR	867328700	66	53,066	SH		SOLE		53,066	0	0
Syros Pharmaceuticals, Inc.	COM	87184Q107	6,101	690,167	SH		SOLE		690,167	0	0
TCR2 Therapeutics Inc.	COM	87808K106	2,490	122,532	SH		SOLE		122,532	0	0
uniQure N.V.	SHS	N90064101	7,159	194,383	SH		SOLE		194,383	0	0
Urovant Sciences Ltd.	SHS	G9381B108	9,139	978,505	SH		SOLE		978,505	0	0
Vaxart, Inc.	COM	92243A200	10,415	1,566,121	SH		SOLE		1,566,121	0	0
Viking Therapeutics, Inc.	COM	92686J106	2,352	404,200	SH		SOLE		404,200	0	0
Xencor, Inc.	COM	98401F105	15,909	410,142	SH		SOLE		410,142	0	0
Xenon Pharmaceuticals Inc.	COM	98420N105	8,417	760,308	SH		SOLE		760,308	0	0
Zymeworks Inc.	COM	98985W102	79,581	1,708,472	SH		SOLE		1,708,472	0	0
BioMarin Pharmaceutical Inc.	NOTE 0.599% 8/1/2024	09061GAH4	15,650	15,000,000	PRN		SOLE		15,000,000	0	0
Invitae Corporation	NOTE 2.0% 9/1/2024	46185LAB9	16,905	10,300,000	PRN		SOLE		10,300,000	0	0
Neurocrine Biosciences, Inc.	NOTE 2.25% 5/15/2024	64125CAD1	42,342	30,770,000	PRN		SOLE		30,770,000	0	0