Baker Bros. Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AbCellera Biologics Inc.	COM	00288U106	420,515	10,450,180	SH		SOLE		10,450,180	0	0
ACADIA Pharmaceuticals Inc.	COM	004225108	2,240,219	41,904,586	SH		SOLE		41,904,586	0	0
Acceleron Pharma Inc.	COM	00434H108	2,870	22,430	SH		SOLE		22,430	0	0
Adamas Pharmaceuticals, Inc.	COM	00548A106	641	147,996	SH		SOLE		147,996	0	0
Adaptive Biotechnologies Corporation	COM	00650F109	22,451	379,682	SH		SOLE		379,682	0	0
Adaptimmune Therapeutics plc	SPONSORED ADR	00653A107	52,988	9,830,877	SH		SOLE		9,830,877	0	0
ADC Therapeutics SA	SHS	H0036K147	45,394	1,418,107	SH		SOLE		1,418,107	0	0
Aeglea BioTherapeutics, Inc.	COM	00773J103	26,838	3,410,106	SH		SOLE		3,410,106	0	0
Affimed N.V.	COM	N01045108	958	164,605	SH		SOLE		164,605	0	0
Akero Therapeutics, Inc.	COM	00973Y108	3,054	118,378	SH		SOLE		118,378	0	0
Albireo Pharma, Inc.	COM	01345P106	15,472	412,466	SH		SOLE		412,466	0	0
Alector, Inc.	COM	014442107	3,620	239,228	SH		SOLE		239,228	0	0
Alexion Pharmaceuticals, Inc.	COM	015351109	1,368,786	8,760,794	SH		SOLE		8,760,794	0	0
Aligos Therapeutics, Inc.	COM	01626L105	44,517	1,610,000	SH		SOLE		1,610,000	0	0
Alkermes plc	SHS	G01767105	30,626	1,535,149	SH		SOLE		1,535,149	0	0
Allakos Inc.	COM	01671P100	99,995	714,250	SH		SOLE		714,250	0	0
Altimmune, Inc.	COM	02155H200	21,257	1,884,451	SH		SOLE		1,884,451	0	0
Amarin Corporation plc	SPONSORED ADR	023111206	136,880	27,991,761	SH		SOLE		27,991,761	0	0
AnaptysBio, Inc.	COM	032724106	9,184	427,179	SH		SOLE		427,179	0	0
Apellis Pharmaceuticals, Inc.	COM	03753U106	51,283	896,551	SH		SOLE		896,551	0	0
Arcus Biosciences, Inc.	COM	03969F109	1,888	72,709	SH		SOLE		72,709	0	0
argenx SE	SPONSORED ADR	04016X101	299,842	1,019,557	SH		SOLE		1,019,557	0	0
Ascendis Pharma A/S	SPONSORED ADR	04351P101	590,446	3,540,270	SH		SOLE		3,540,270	0	0
Assembly Biosciences, Inc.	COM	045396108	9,326	1,541,418	SH		SOLE		1,541,418	0	0
Atreca, Inc.	CL A COM	04965G109	57,054	3,532,760	SH		SOLE		3,532,760	0	0
Athira Pharma, Inc.	COM	04746L104	27,618	806,367	SH		SOLE		806,367	0	0
Aurinia Pharmaceuticals Inc.	COM	05156V102	19,501	1,410,064	SH		SOLE		1,410,064	0	0
Autolus Therapeutics plc	SPONSORED ADS	05280R100	6,993	782,183	SH		SOLE		782,183	0	0
Axsome Therapeutics, Inc.	COM	05464T104	63,452	778,834	SH		SOLE		778,834	0	0
BeiGene, Ltd.	SPONSORED ADR	07725L102	3,015,126	11,668,897	SH		SOLE		11,668,897	0	0
Bellicum Pharmaceuticals, Inc.	COM	079481404	879	249,123	SH		SOLE		249,123	0	0
BioAtla, Inc.	COM	09077B104	28,058	825,000	SH		SOLE		825,000	0	0
BioCryst Pharmaceuticals, Inc.	COM	09058V103	94,584	12,695,818	SH		SOLE		12,695,818	0	0
BioMarin Pharmaceutical Inc.	COM	09061G101	665,505	7,589,294	SH		SOLE		7,589,294	0	0
bluebird bio, Inc.	COM	09609G100	9,822	226,988	SH		SOLE		226,988	0	0
Burning Rock Biotech Limited	SPONSORED ADS	12233L107	4,831	209,131	SH		SOLE		209,131	0	0
Cabaletta Bio, Inc.	COM	12674W109	7,942	636,363	SH		SOLE		636,363	0	0
Cerus Corporation	COM	157085101	94,895	13,713,195	SH		SOLE		13,713,195	0	0
ChemoCentryx, Inc.	COM	16383L106	40,663	656,710	SH		SOLE		656,710	0	0
Chiasma, Inc.	COM	16706W102	3,228	742,133	SH		SOLE		742,133	0	0
Chinook Therapeutics, Inc.	COM	16961L106	11,874	748,693	SH		SOLE		748,693	0	0
Constellation Pharmaceuticals, Inc.	COM	210373106	3,304	114,735	SH		SOLE		114,735	0	0
Crinetics Pharmaceuticals, Inc.	COM	22663K107	8,699	616,520	SH		SOLE		616,520	0	0
Cymabay Therapeutics, Inc.	COM	23257D103	16,607	2,893,276	SH		SOLE		2,893,276	0	0
DBV Technologies S.A.	SPONSORED ADR	23306J101	38,289	14,614,264	SH		SOLE		14,614,264	0	0
Denali Therapeutics Inc.	COM	24823R105	7,433	88,738	SH		SOLE		88,738	0	0
Dicerna Pharmaceuticals, Inc.	COM	253031108	2,250	102,121	SH		SOLE		102,121	0	0
Evofem Biosciences, Inc.	COM	30048L104	991	411,396	SH		SOLE		411,396	0	0
Five Prime Therapeutics, Inc.	COM	33830X104	11,363	668,000	SH		SOLE		668,000	0	0
Frequency Therapeutics, Inc.	COM	35803L108	30,200	856,507	SH		SOLE		856,507	0	0
Forma Therapeutics Holdings, Inc.	SHS	34633R104	70,668	2,024,876	SH		SOLE		2,024,876	0	0
Fulgent Genetics, Inc.	COM	359664109	25,819	495,573	SH		SOLE		495,573	0	0
Galapagos NV	SPONSORED ADR	36315X101	1,107	11,180	SH		SOLE		11,180	0	0
Galmed Pharmaceuticals Ltd.	SHS	M47238106	575	184,927	SH		SOLE		184,927	0	0
Gamida Cell Ltd.	SHS	M47364100	12,990	1,548,314	SH		SOLE		1,548,314	0	0
Genetron Holdings Limited	ADS	37186H100	6,374	455,306	SH		SOLE		455,306	0	0
Genfit SA	ADS	372279109	71	14,720	SH		SOLE		14,720	0	0
Global Blood Therapeutics, Inc.	COM	37890U108	39,861	920,375	SH		SOLE		920,375	0	0
Gossamer Bio, Inc.	COM	38341P102	4,649	480,729	SH		SOLE		480,729	0	0
GW Pharmaceuticals plc	ADS	36197T103	13,029	112,897	SH		SOLE		112,897	0	0
Harmony Biosciences Holdings, Inc.	COM	413197104	6,507	180,000	SH		SOLE		180,000	0	0
Heron Therapeutics, Inc.	COM	427746102	126,878	5,994,704	SH		SOLE		5,994,704	0	0
HOOKIPA Pharma Inc.	COM	43906K100	7,768	700,481	SH		SOLE		700,481	0	0
Horizon Therapeutics Public Ltd Co	SHS	G46188101	43,825	599,110	SH		SOLE		599,110	0	0
Idera Pharmaceuticals, Inc.	COM PAR	45168K405	16,914	4,608,786	SH		SOLE		4,608,786	0	0
IGM Biosciences, Inc.	COM	449585108	277,663	3,144,892	SH		SOLE		3,144,892	0	0
Immatics N.V.	SHS	N44445109	19,476	1,805,025	SH		SOLE		1,805,025	0	0
Incyte Corporation	COM	45337C102	2,783,337	31,999,741	SH		SOLE		31,999,741	0	0
Infinity Pharmaceuticals, Inc.	COM	45665G303	1,107	522,360	SH		SOLE		522,360	0	0
Inflarx N.V.	COM	N44821101	4,307	856,228	SH		SOLE		856,228	0	0
Inozyme Pharma, Inc.	COM	45790W108	2,208	106,999	SH		SOLE		106,999	0	0
Insmed Incorporated	COM PAR $.01	457669307	71,773	2,156,001	SH		SOLE		2,156,001	0	0
Intellia Therapeutics, Inc.	COM	45826J105	6,055	111,296	SH		SOLE		111,296	0	0
Invitae Corporation	COM	46185L103	654,292	15,649,182	SH		SOLE		15,649,182	0	0
Iteos Therapeutics, Inc.	COM	46565G104	5,085	150,346	SH		SOLE		150,346	0	0
IVERIC bio, Inc.	COM	46583P102	9,716	1,406,037	SH		SOLE		1,406,037	0	0
Karuna Therapeutics, Inc.	COM	48576A100	7,108	69,966	SH		SOLE		69,966	0	0
Kezar Life Sciences, Inc.	COM	49372L100	729	139,676	SH		SOLE		139,676	0	0
Kiniksa Pharmaceuticals, Ltd.	COM CL A	G5269C101	49,469	2,799,577	SH		SOLE		2,799,577	0	0
Kymera Therapeutics, Inc.	COM	501575104	121,471	1,959,211	SH		SOLE		1,959,211	0	0
Kodiak Sciences Inc.	COM	50015M109	2,039,104	13,879,952	SH		SOLE		13,879,952	0	0
Krystal Biotech, Inc.	COM	501147102	41,932	698,874	SH		SOLE		698,874	0	0
Leap Therapeutics, Inc.	COM	52187K101	1,259	559,705	SH		SOLE		559,705	0	0
Legend Biotech Corporation	SPONSORED ADS	52490G102	3,256	115,626	SH		SOLE		115,626	0	0
LogicBio Therapeutics, Inc.	COM	54142F102	3,445	451,478	SH		SOLE		451,478	0	0
MacroGenics, Inc.	COM	556099109	4,588	200,679	SH		SOLE		200,679	0	0
Madrigal Pharmaceuticals, Inc.	COM	558868105	166,668	1,499,213	SH		SOLE		1,499,213	0	0
Mereo BioPharma Group plc	ADS	589492107	21,588	6,030,293	SH		SOLE		6,030,293	0	0
Merus N.V.	COM	N5749R100	35,717	2,037,469	SH		SOLE		2,037,469	0	0
Mirati Therapeutics, Inc.	COM	60468T105	309,645	1,409,784	SH		SOLE		1,409,784	0	0
Mirum Pharmaceuticals, Inc.	COM	604749101	11,302	647,313	SH		SOLE		647,313	0	0
Molecular Templates, Inc.	COM	608550109	1,257	133,833	SH		SOLE		133,833	0	0
Neoleukin Therapeutics, Inc.	COM	64049K104	53,887	3,821,740	SH		SOLE		3,821,740	0	0
Neurocrine Biosciences, Inc.	COM	64125C109	64,888	676,975	SH		SOLE		676,975	0	0
NGM Biopharmaceuticals, Inc.	COM	62921N105	3,230	106,616	SH		SOLE		106,616	0	0
Novavax, Inc.	COM	670002401	18,924	169,706	SH		SOLE		169,706	0	0
Nurix Therapeutics, Inc.	COM	67080M103	58,820	1,788,921	SH		SOLE		1,788,921	0	0
Opthea Limited	SPONSORED ADS	68386J208	37,107	3,308,705	SH		SOLE		3,308,705	0	0
Orchard Therapeutics plc	ADS	68570P101	1,436	332,502	SH		SOLE		332,502	0	0
Ovid Therapeutics Inc.	COM	690469101	2,208	955,690	SH		SOLE		955,690	0	0
Oyster Point Pharma, Inc.	COM	69242L106	1,156	61,424	SH		SOLE		61,424	0	0
Pacific Biosciences of California, Inc.	COM	69404D108	83,059	3,201,972	SH		SOLE		3,201,972	0	0
Passage Bio, Inc.	COM	702712100	6,018	235,362	SH		SOLE		235,362	0	0
Prelude Therapeutics Incorporated	COM	74065P101	723,988	10,118,636	SH		SOLE		10,118,636	0	0
Protagonist Therapeutics, Inc.	COM	74366E102	28,954	1,436,192	SH		SOLE		1,436,192	0	0
Protara Therapeutics, Inc.	COM STK	74365U107	4,834	199,671	SH		SOLE		199,671	0	0
Reata Pharmaceuticals, Inc.	CL A	75615P103	27,688	223,976	SH		SOLE		223,976	0	0
Replimune Group, Inc.	COM	76029N106	5,856	153,512	SH		SOLE		153,512	0	0
Rhythm Pharmaceuticals, Inc.	COM	76243J105	68,821	2,314,873	SH		SOLE		2,314,873	0	0
Sangamo Therapeutics, Inc.	COM	800677106	13,379	857,339	SH		SOLE		857,339	0	0
Seagen Inc.	COM	81181C104	8,278,767	47,269,424	SH		SOLE		47,269,424	0	0
Silverback Therapeutics, Inc.	COM	82835W108	11,033	238,095	SH		SOLE		238,095	0	0
Sunesis Pharmaceuticals, Inc.	COM	867328874	106	53,066	SH		SOLE		53,066	0	0
Syros Pharmaceuticals, Inc.	COM	87184Q107	7,488	690,167	SH		SOLE		690,167	0	0
TCR2 Therapeutics Inc.	COM	87808K106	3,430	110,888	SH		SOLE		110,888	0	0
Tricida, Inc.	COM	89610F101	4,437	629,300	SH		SOLE		629,300	0	0
Ultragenyx Pharmaceutical Inc.	COM	90400D108	61,524	444,444	SH		SOLE		444,444	0	0
uniQure N.V.	SHS	N90064101	244	6,740	SH		SOLE		6,740	0	0
Vaxart, Inc.	COM	92243A200	7,987	1,398,795	SH		SOLE		1,398,795	0	0
Verastem, Inc.	COM	92337C104	21,607	10,144,039	SH		SOLE		10,144,039	0	0
Viking Therapeutics, Inc.	COM	92686J106	2,049	363,980	SH		SOLE		363,980	0	0
Xencor, Inc.	COM	98401F105	16,116	369,370	SH		SOLE		369,370	0	0
Xenon Pharmaceuticals Inc.	COM	98420N105	10,572	687,386	SH		SOLE		687,386	0	0
Zymeworks Inc.	COM	98985W102	80,742	1,708,472	SH		SOLE		1,708,472	0	0
BioMarin Pharmaceutical Inc.	NOTE 0.599% 8/1/2024	09061GAH4	16,033	15,000,000	PRN		SOLE		15,000,000	0	0
Invitae Corporation	NOTE 2.0% 9/1/2024	46185LAB9	16,446	10,300,000	PRN		SOLE		10,300,000	0	0