Baker Bros. Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
AbCellera Biologics Inc.	COM	00288U106	229,904	10,450,180	SH		SOLE		10,450,180	0	0
ACADIA Pharmaceuticals Inc.	COM	004225108	1,022,202	41,910,704	SH		SOLE		41,910,704	0	0
Acceleron Pharma Inc.	COM	00434H108	2,815	22,430	SH		SOLE		22,430	0	0
Achilles Therapeutics plc	SPONSORED ADS	00449L102	25,369	2,591,366	SH		SOLE		2,591,366	0	0
Adaptimmune Therapeutics plc	SPONSORED ADR	00653A107	41,880	9,830,877	SH		SOLE		9,830,877	0	0
ADC Therapeutics SA	SHS	H0036K147	34,531	1,418,107	SH		SOLE		1,418,107	0	0
Aeglea BioTherapeutics, Inc.	COM	00773J103	23,734	3,410,106	SH		SOLE		3,410,106	0	0
Aerovate Therapeutics, Inc.	COM	008064107	32,614	1,428,571	SH		SOLE		1,428,571	0	0
Affimed N.V.	COM	N01045108	1,399	164,605	SH		SOLE		164,605	0	0
Akero Therapeutics, Inc.	COM	00973Y108	2,937	118,378	SH		SOLE		118,378	0	0
Albireo Pharma, Inc.	COM	01345P106	14,511	412,466	SH		SOLE		412,466	0	0
Alector, Inc.	COM	014442107	4,983	239,228	SH		SOLE		239,228	0	0
Aligos Therapeutics, Inc.	COM	01626L105	32,820	1,610,000	SH		SOLE		1,610,000	0	0
Alkermes plc	SHS	G01767105	30,115	1,228,170	SH		SOLE		1,228,170	0	0
Allakos Inc.	COM	01671P100	60,019	703,050	SH		SOLE		703,050	0	0
Altimmune, Inc.	COM	02155H200	10,560	1,072,038	SH		SOLE		1,072,038	0	0
Amarin Corporation plc	SPONSORED ADR	023111206	115,866	26,453,422	SH		SOLE		26,453,422	0	0
AnaptysBio, Inc.	COM	032724106	11,077	427,179	SH		SOLE		427,179	0	0
Apellis Pharmaceuticals, Inc.	COM	03753U106	143,585	2,271,917	SH		SOLE		2,271,917	0	0
argenx SE	SPONSORED ADR	04016X101	337,065	1,119,557	SH		SOLE		1,119,557	0	0
Ascendis Pharma A/S	SPONSORED ADR	04351P101	465,723	3,540,270	SH		SOLE		3,540,270	0	0
Assembly Biosciences, Inc.	COM	045396108	8,181	2,108,621	SH		SOLE		2,108,621	0	0
Athira Pharma, Inc.	COM	04746L104	8,257	806,367	SH		SOLE		806,367	0	0
Atreca, Inc.	CL A COM	04965G109	30,099	3,532,760	SH		SOLE		3,532,760	0	0
Aurinia Pharmaceuticals Inc.	COM	05156V102	14,515	1,119,962	SH		SOLE		1,119,962	0	0
Axsome Therapeutics, Inc.	COM	05464T104	36,365	539,057	SH		SOLE		539,057	0	0
BeiGene, Ltd.	SPONSORED ADR	07725L102	4,004,649	11,668,897	SH		SOLE		11,668,897	0	0
Bellicum Pharmaceuticals, Inc.	COM	079481404	822	249,123	SH		SOLE		249,123	0	0
BioAtla, Inc.	COM	09077B104	34,964	825,000	SH		SOLE		825,000	0	0
BioCryst Pharmaceuticals, Inc.	COM	09058V103	200,958	12,710,818	SH		SOLE		12,710,818	0	0
BioMarin Pharmaceutical Inc.	COM	09061G101	633,251	7,589,294	SH		SOLE		7,589,294	0	0
Biomea Fusion, Inc.	COM	09077A106	4,591	294,117	SH		SOLE		294,117	0	0
bluebird bio, Inc.	COM	09609G100	7,259	226,988	SH		SOLE		226,988	0	0
Burning Rock Biotech Limited	SPONSORED ADS	12233L107	6,161	209,131	SH		SOLE		209,131	0	0
Cabaletta Bio, Inc.	COM	12674W109	5,473	636,363	SH		SOLE		636,363	0	0
Centessa Pharmaceuticals plc	SPONSORED ADS	152309100	8,884	400,000	SH		SOLE		400,000	0	0
Cerus Corporation	COM	157085101	81,045	13,713,195	SH		SOLE		13,713,195	0	0
Chiasma, Inc.	COM	16706W102	6,720	1,420,740	SH		SOLE		1,420,740	0	0
Chinook Therapeutics, Inc.	COM	16961L106	15,255	1,080,393	SH		SOLE		1,080,393	0	0
Crinetics Pharmaceuticals, Inc.	COM	22663K107	17,354	920,656	SH		SOLE		920,656	0	0
Cymabay Therapeutics, Inc.	COM	23257D103	9,463	2,170,464	SH		SOLE		2,170,464	0	0
Cyteir Therapeutics, Inc.	COM	23284P103	17,390	812,640	SH		SOLE		812,640	0	0
DBV Technologies S.A.	SPONSORED ADR	23306J101	79,794	14,614,264	SH		SOLE		14,614,264	0	0
Denali Therapeutics Inc.	COM	24823R105	6,961	88,738	SH		SOLE		88,738	0	0
Design Therapeutics, Inc.	COM	25056L103	28,575	1,436,636	SH		SOLE		1,436,636	0	0
Edgewise Therapeutics, Inc.	COM	28036F105	10,665	500,000	SH		SOLE		500,000	0	0
Evofem Biosciences, Inc.	COM	30048L104	3,048	2,697,110	SH		SOLE		2,697,110	0	0
Forma Therapeutics Holdings, Inc.	SHS	34633R104	50,399	2,024,876	SH		SOLE		2,024,876	0	0
Frequency Therapeutics, Inc.	COM	35803L108	553	55,555	SH		SOLE		55,555	0	0
Fulgent Genetics, Inc.	COM	359664109	36,986	401,016	SH		SOLE		401,016	0	0
Gamida Cell Ltd.	SHS	M47364100	3,914	610,626	SH		SOLE		610,626	0	0
Genetron Holdings Limited	ADS	37186H100	9,170	455,306	SH		SOLE		455,306	0	0
Global Blood Therapeutics, Inc.	COM	37890U108	112,675	3,217,441	SH		SOLE		3,217,441	0	0
Harmony Biosciences Holdings, Inc.	COM	413197104	3,489	123,600	SH		SOLE		123,600	0	0
Heron Therapeutics, Inc.	COM	427746102	126,204	8,131,678	SH		SOLE		8,131,678	0	0
HOOKIPA Pharma Inc.	COM	43906K100	6,416	700,481	SH		SOLE		700,481	0	0
Horizon Therapeutics Public Ltd Co	SHS	G46188101	56,101	599,110	SH		SOLE		599,110	0	0
IGM Biosciences, Inc.	COM	449585108	262,588	3,156,102	SH		SOLE		3,156,102	0	0
Immatics N.V.	SHS	N44445109	49,725	4,282,938	SH		SOLE		4,282,938	0	0
Immunocore Holdings plc	ADS	45258D105	98,435	2,520,730	SH		SOLE		2,520,730	0	0
Incyte Corporation	COM	45337C102	2,693,988	32,021,732	SH		SOLE		32,021,732	0	0
Inozyme Pharma, Inc.	COM	45790W108	1,823	106,999	SH		SOLE		106,999	0	0
Insmed Incorporated	COM PAR $.01	457669307	61,360	2,156,001	SH		SOLE		2,156,001	0	0
Instil Bio, Inc.	COM	45783C101	75,226	3,893,700	SH		SOLE		3,893,700	0	0
Invitae Corporation	COM	46185L103	345,684	10,248,575	SH		SOLE		10,248,575	0	0
Iteos Therapeutics, Inc.	COM	46565G104	3,856	150,346	SH		SOLE		150,346	0	0
IVERIC bio, Inc.	COM	46583P102	8,872	1,406,037	SH		SOLE		1,406,037	0	0
Karuna Therapeutics, Inc.	COM	48576A100	7,975	69,966	SH		SOLE		69,966	0	0
Kezar Life Sciences, Inc.	COM	49372L100	758	139,676	SH		SOLE		139,676	0	0
Kiniksa Pharmaceuticals, Ltd.	COM CL A	G5269C101	38,998	2,799,577	SH		SOLE		2,799,577	0	0
Kodiak Sciences Inc.	COM	50015M109	1,314,823	14,137,881	SH		SOLE		14,137,881	0	0
Krystal Biotech, Inc.	COM	501147102	41,326	607,735	SH		SOLE		607,735	0	0
Kymera Therapeutics, Inc.	COM	501575104	95,022	1,959,211	SH		SOLE		1,959,211	0	0
Leap Therapeutics, Inc.	COM	52187K101	918	559,705	SH		SOLE		559,705	0	0
Legend Biotech Corporation	SPONSORED ADS	52490G102	68,329	1,664,534	SH		SOLE		1,664,534	0	0
LogicBio Therapeutics, Inc.	COM	54142F102	2,005	451,478	SH		SOLE		451,478	0	0
MacroGenics, Inc.	COM	556099109	5,390	200,679	SH		SOLE		200,679	0	0
Madrigal Pharmaceuticals, Inc.	COM	558868105	146,038	1,499,213	SH		SOLE		1,499,213	0	0
Mereo BioPharma Group plc	ADS	589492107	7,796	2,459,399	SH		SOLE		2,459,399	0	0
Merus N.V.	COM	N5749R100	42,929	2,037,469	SH		SOLE		2,037,469	0	0
Mirati Therapeutics, Inc.	COM	60468T105	227,722	1,409,784	SH		SOLE		1,409,784	0	0
Mirum Pharmaceuticals, Inc.	COM	604749101	11,192	647,313	SH		SOLE		647,313	0	0
Neoleukin Therapeutics, Inc.	COM	64049K104	35,275	3,821,740	SH		SOLE		3,821,740	0	0
Neurocrine Biosciences, Inc.	COM	64125C109	65,883	676,975	SH		SOLE		676,975	0	0
NexImmune, Inc.	COM	65344D109	4,800	294,117	SH		SOLE		294,117	0	0
NGM Biopharmaceuticals, Inc.	COM	62921N105	5,754	291,801	SH		SOLE		291,801	0	0
Novavax, Inc.	COM	670002401	30,521	143,756	SH		SOLE		143,756	0	0
Nurix Therapeutics, Inc.	COM	67080M103	65,107	2,454,082	SH		SOLE		2,454,082	0	0
Opthea Limited	SPONSORED ADS	68386J208	27,092	3,412,062	SH		SOLE		3,412,062	0	0
Orchard Therapeutics plc	ADS	68570P101	5,233	1,192,003	SH		SOLE		1,192,003	0	0
Otonomy, Inc.	COM	68906L105	16,106	7,222,474	SH		SOLE		7,222,474	0	0
Oyster Point Pharma, Inc.	COM	69242L106	1,056	61,424	SH		SOLE		61,424	0	0
Pacific Biosciences of California, Inc.	COM	69404D108	111,973	3,201,972	SH		SOLE		3,201,972	0	0
Passage Bio, Inc.	COM	702712100	1,551	117,161	SH		SOLE		117,161	0	0
Prelude Therapeutics Incorporated	COM	74065P101	289,845	10,123,824	SH		SOLE		10,123,824	0	0
Protagonist Therapeutics, Inc.	COM	74366E102	20,433	455,276	SH		SOLE		455,276	0	0
Protara Therapeutics, Inc.	COM STK	74365U107	1,945	199,671	SH		SOLE		199,671	0	0
Reata Pharmaceuticals, Inc.	CL A	75615P103	31,699	223,976	SH		SOLE		223,976	0	0
Relmada Therapeutics, Inc.	COM	75955J402	2,452	76,600	SH		SOLE		76,600	0	0
Replimune Group, Inc.	COM	76029N106	5,898	153,512	SH		SOLE		153,512	0	0
Revolution Medicines, Inc.	COM	76155X100	7,053	222,222	SH		SOLE		222,222	0	0
Rhythm Pharmaceuticals, Inc.	COM	76243J105	75,642	3,863,239	SH		SOLE		3,863,239	0	0
Seagen Inc.	COM	81181C104	7,465,870	47,288,259	SH		SOLE		47,288,259	0	0
Silverback Therapeutics, Inc.	COM	82835W108	7,355	238,095	SH		SOLE		238,095	0	0
Syros Pharmaceuticals, Inc.	COM	87184Q107	357	65,497	SH		SOLE		65,497	0	0
Talis Biomedical Corporation	COM	87424L108	83,550	7,574,835	SH		SOLE		7,574,835	0	0
TCR2 Therapeutics Inc.	COM	87808K106	2,896	176,461	SH		SOLE		176,461	0	0
Travere Therapeutics, Inc.	COM	89422G107	2,727	186,915	SH		SOLE		186,915	0	0
Tricida, Inc.	COM	89610F101	3,151	729,300	SH		SOLE		729,300	0	0
Ultragenyx Pharmaceutical Inc.	COM	90400D108	42,378	444,444	SH		SOLE		444,444	0	0
Verastem, Inc.	COM	92337C104	87,471	21,491,630	SH		SOLE		21,491,630	0	0
Verve Therapeutics, Inc.	COM	92539P101	85,346	1,416,530	SH		SOLE		1,416,530	0	0
Xenon Pharmaceuticals Inc.	COM	98420N105	13,996	751,639	SH		SOLE		751,639	0	0
Zymeworks Inc.	COM	98985W102	59,267	1,708,472	SH		SOLE		1,708,472	0	0
Apellis Pharmaceuticals, Inc.	Note 3.5% 9/15/2026	03753UAB2	27,793	15,000,000	PRN		SOLE		15,000,000	0	0
BioMarin Pharmaceutical Inc.	Note 0.599% 8/1/2024	09061GAH4	15,566	15,000,000	PRN		SOLE		15,000,000	0	0
Insmed Incorporated	Note 0.75% 6/1/2028	457669AB5	44,063	40,000,000	PRN		SOLE		40,000,000	0	0
Invitae Corporation	Note 2.0% 9/1/2024	46185LAB9	13,890	10,300,000	PRN		SOLE		10,300,000	0	0
Sarepta Therapeutics, Inc.	DBCV 1.5% 11/15/2024	803607AB6	38,479	29,174,000	PRN		SOLE		29,174,000	0	0
Tricida, Inc.	Note 3.5% 5/15/2027	89610FAB7	27,332	75,000,000	PRN		SOLE		75,000,000	0	0