Baker Bros. Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
2seventy bio, Inc.	COMMON STOCK	901384107	21,356	833,236	SH		SOLE		833,236	0	0
AbCellera Biologics Inc.	COM	00288U106	149,438	10,450,180	SH		SOLE		10,450,180	0	0
ACADIA Pharmaceuticals Inc.	COM	004225108	978,196	41,910,704	SH		SOLE		41,910,704	0	0
Achilles Therapeutics plc	SPONSORED ADS	00449L102	12,983	2,591,366	SH		SOLE		2,591,366	0	0
Adaptimmune Therapeutics plc	SPONSORED ADR	00653A107	36,866	9,830,877	SH		SOLE		9,830,877	0	0
Aeglea BioTherapeutics, Inc.	COM	00773J103	16,198	3,410,106	SH		SOLE		3,410,106	0	0
Aerovate Therapeutics, Inc.	COM	008064107	21,597	1,831,789	SH		SOLE		1,831,789	0	0
Affimed N.V.	COM	N01045108	14,645	2,653,169	SH		SOLE		2,653,169	0	0
Akero Therapeutics, Inc.	COM	00973Y108	2,504	118,378	SH		SOLE		118,378	0	0
Albireo Pharma, Inc.	COM	01345P106	2,434	104,521	SH		SOLE		104,521	0	0
Alector, Inc.	COM	014442107	4,940	239,228	SH		SOLE		239,228	0	0
Aligos Therapeutics, Inc.	COM	01626L105	24,647	2,076,400	SH		SOLE		2,076,400	0	0
Alkermes plc	SHS	G01767105	34,890	1,500,000	SH		SOLE		1,500,000	0	0
Allakos Inc.	COM	01671P100	6,883	703,050	SH		SOLE		703,050	0	0
Altimmune, Inc.	COM	02155H200	9,820	1,072,038	SH		SOLE		1,072,038	0	0
Amarin Corporation plc	SPONSORED ADR	023111206	71,342	21,169,805	SH		SOLE		21,169,805	0	0
AnaptysBio, Inc.	COM	032724106	14,844	427,179	SH		SOLE		427,179	0	0
argenx SE	SPONSORED ADR	04016X101	392,058	1,119,557	SH		SOLE		1,119,557	0	0
Ascendis Pharma A/S	SPONSORED ADR	04351P101	610,982	4,541,604	SH		SOLE		4,541,604	0	0
Athira Pharma, Inc.	COM	04746L104	10,507	806,367	SH		SOLE		806,367	0	0
Atreca, Inc.	CL A COM	04965G109	10,704	3,532,760	SH		SOLE		3,532,760	0	0
aTyr Pharma, Inc.	COM	002120202	4,669	625,000	SH		SOLE		625,000	0	0
Axsome Therapeutics, Inc.	COM	05464T104	23,082	610,970	SH		SOLE		610,970	0	0
BeiGene, Ltd.	SPONSORED ADR	07725L102	3,161,454	11,668,897	SH		SOLE		11,668,897	0	0
Bellicum Pharmaceuticals, Inc.	COM	079481404	371	249,123	SH		SOLE		249,123	0	0
BioAtla, Inc.	COM	09077B104	16,195	825,000	SH		SOLE		825,000	0	0
BioCryst Pharmaceuticals, Inc.	COM	09058V103	176,045	12,710,818	SH		SOLE		12,710,818	0	0
BioMarin Pharmaceutical Inc.	COM	09061G101	673,271	7,620,494	SH		SOLE		7,620,494	0	0
Biomea Fusion, Inc.	COM	09077A106	3,908	524,617	SH		SOLE		524,617	0	0
bluebird bio, Inc.	COM	09609G100	24,972	2,499,715	SH		SOLE		2,499,715	0	0
Burning Rock Biotech Limited	SPONSORED ADS	12233L107	1,993	209,131	SH		SOLE		209,131	0	0
Cabaletta Bio, Inc.	COM	12674W109	2,509	662,063	SH		SOLE		662,063	0	0
Centessa Pharmaceuticals plc	SPONSORED ADS	152309100	12,693	1,127,273	SH		SOLE		1,127,273	0	0
Cerus Corporation	COM	157085101	93,387	13,713,195	SH		SOLE		13,713,195	0	0
ChemoCentryx, Inc.	COM	16383L106	59,394	1,631,266	SH		SOLE		1,631,266	0	0
Chinook Therapeutics, Inc.	COM	16961L106	38,069	2,334,102	SH		SOLE		2,334,102	0	0
Crinetics Pharmaceuticals, Inc.	COM	22663K107	23,509	827,480	SH		SOLE		827,480	0	0
CymaBay Therapeutics, Inc.	COM	23257D103	7,336	2,170,464	SH		SOLE		2,170,464	0	0
Cyteir Therapeutics, Inc.	COM	23284P103	9,240	812,640	SH		SOLE		812,640	0	0
DBV Technologies S.A.	SPONSORED ADR	23306J101	23,383	14,614,264	SH		SOLE		14,614,264	0	0
Denali Therapeutics Inc.	COM	24823R105	3,958	88,738	SH		SOLE		88,738	0	0
Design Therapeutics, Inc.	COM	25056L103	30,758	1,436,636	SH		SOLE		1,436,636	0	0
DICE Therapeutics, Inc.	COM	23345J104	14,888	588,235	SH		SOLE		588,235	0	0
Edgewise Therapeutics, Inc.	COM	28036F105	7,640	500,000	SH		SOLE		500,000	0	0
Entrada Therapeutics, Inc.	COM	29384C108	80,540	4,704,419	SH		SOLE		4,704,419	0	0
Evofem Biosciences, Inc.	COM	30048L104	1,013	2,697,110	SH		SOLE		2,697,110	0	0
FibroGen, Inc.	COM	31572Q808	8,180	580,150	SH		SOLE		580,150	0	0
Foghorn Therapeutics Inc.	COM	344174107	1,030	45,027	SH		SOLE		45,027	0	0
Forma Therapeutics Holdings, Inc.	SHS	34633R104	28,794	2,024,876	SH		SOLE		2,024,876	0	0
Fulgent Genetics, Inc.	COM	359664109	20,263	201,444	SH		SOLE		201,444	0	0
Gamida Cell Ltd.	SHS	M47364100	1,551	610,626	SH		SOLE		610,626	0	0
Genetron Holdings Limited	ADS	37186H100	2,777	455,306	SH		SOLE		455,306	0	0
Global Blood Therapeutics, Inc.	COM	37890U108	97,023	3,314,765	SH		SOLE		3,314,765	0	0
Harmony Biosciences Holdings, Inc.	COM	413197104	5,270	123,600	SH		SOLE		123,600	0	0
Heron Therapeutics, Inc.	COM	427746102	74,242	8,131,678	SH		SOLE		8,131,678	0	0
HOOKIPA Pharma Inc.	COM	43906K100	1,632	700,481	SH		SOLE		700,481	0	0
Horizon Therapeutics Public Ltd Co	SHS	G46188101	64,560	599,110	SH		SOLE		599,110	0	0
IGM Biosciences, Inc.	COM	449585108	92,568	3,156,102	SH		SOLE		3,156,102	0	0
Immatics N.V.	SHS	N44445109	59,455	4,423,731	SH		SOLE		4,423,731	0	0
Immunocore Holdings plc	ADS	45258D105	86,310	2,520,730	SH		SOLE		2,520,730	0	0
Incyte Corporation	COM	45337C102	2,467,566	33,618,063	SH		SOLE		33,618,063	0	0
Inozyme Pharma, Inc.	COM	45790W108	730	106,999	SH		SOLE		106,999	0	0
Insmed Incorporated	COM PAR $.01	457669307	58,729	2,156,001	SH		SOLE		2,156,001	0	0
Instil Bio, Inc.	COM	45783C101	66,621	3,893,700	SH		SOLE		3,893,700	0	0
Invitae Corporation	COM	46185L103	150,768	9,873,488	SH		SOLE		9,873,488	0	0
Iteos Therapeutics, Inc.	COM	46565G104	7,000	150,346	SH		SOLE		150,346	0	0
Karuna Therapeutics, Inc.	COM	48576A100	9,166	69,966	SH		SOLE		69,966	0	0
Kezar Life Sciences, Inc.	COM	49372L100	2,335	139,676	SH		SOLE		139,676	0	0
Kiniksa Pharmaceuticals, Ltd.	COM CL A	G5269C101	32,951	2,799,577	SH		SOLE		2,799,577	0	0
Kodiak Sciences Inc.	COM	50015M109	1,244,681	14,681,304	SH		SOLE		14,681,304	0	0
Krystal Biotech, Inc.	COM	501147102	56,501	807,735	SH		SOLE		807,735	0	0
Kura Oncology, Inc.	COM	50127T109	4,258	304,158	SH		SOLE		304,158	0	0
Kymera Therapeutics, Inc.	COM	501575104	151,407	2,384,742	SH		SOLE		2,384,742	0	0
Leap Therapeutics, Inc.	COM	52187K101	1,813	559,705	SH		SOLE		559,705	0	0
Legend Biotech Corporation	SPONSORED ADS	52490G102	116,012	2,489,003	SH		SOLE		2,489,003	0	0
LogicBio Therapeutics, Inc.	COM	54142F102	1,043	451,478	SH		SOLE		451,478	0	0
MacroGenics, Inc.	COM	556099109	7,103	442,579	SH		SOLE		442,579	0	0
Madrigal Pharmaceuticals, Inc.	COM	558868105	127,043	1,499,213	SH		SOLE		1,499,213	0	0
Merus N.V.	COM	N5749R100	64,792	2,037,469	SH		SOLE		2,037,469	0	0
Mirati Therapeutics, Inc.	COM	60468T105	206,801	1,409,784	SH		SOLE		1,409,784	0	0
Neoleukin Therapeutics, Inc.	COM	64049K104	18,421	3,821,740	SH		SOLE		3,821,740	0	0
Neurocrine Biosciences, Inc.	COM	64125C109	57,658	676,975	SH		SOLE		676,975	0	0
NexImmune, Inc.	COM	65344D109	1,356	294,117	SH		SOLE		294,117	0	0
NGM Biopharmaceuticals, Inc.	COM	62921N105	5,168	291,801	SH		SOLE		291,801	0	0
Novavax, Inc.	COM	670002401	6,891	48,168	SH		SOLE		48,168	0	0
Nurix Therapeutics, Inc.	COM	67080M103	71,046	2,454,082	SH		SOLE		2,454,082	0	0
Opthea Limited	SPONSORED ADS	68386J208	24,115	3,196,191	SH		SOLE		3,196,191	0	0
Otonomy, Inc.	COM	68906L105	16,317	7,844,692	SH		SOLE		7,844,692	0	0
Oyster Point Pharma, Inc.	COM	69242L106	1,122	61,424	SH		SOLE		61,424	0	0
Pacific Biosciences of California, Inc.	COM	69404D108	111,404	5,444,963	SH		SOLE		5,444,963	0	0
Passage Bio, Inc.	COM	702712100	744	117,161	SH		SOLE		117,161	0	0
Prelude Therapeutics Inc.	COM	74065P101	126,042	10,123,824	SH		SOLE		10,123,824	0	0
Protara Therapeutics, Inc.	COM STK	74365U107	1,348	199,671	SH		SOLE		199,671	0	0
Reata Pharmaceuticals, Inc.	CL A	75615P103	5,906	223,976	SH		SOLE		223,976	0	0
Relmada Therapeutics, Inc.	COM	75955J402	11,155	495,113	SH		SOLE		495,113	0	0
Replimune Group, Inc.	COM	76029N106	16,081	593,395	SH		SOLE		593,395	0	0
Revolution Medicines, Inc.	COM	76155X100	5,593	222,222	SH		SOLE		222,222	0	0
Rhythm Pharmaceuticals, Inc.	COM	76243J105	38,555	3,863,239	SH		SOLE		3,863,239	0	0
Sarepta Therapeutics, Inc.	COM	803607100	11,117	123,456	SH		SOLE		123,456	0	0
Seagen Inc.	COM	81181C104	7,249,714	46,893,364	SH		SOLE		46,893,364	0	0
Sera Prognostics, Inc.	CLASS A COM	81749D107	1,385	201,562	SH		SOLE		201,562	0	0
Surrozen, Inc.	COM	86889P109	16,100	2,500,000	SH		SOLE		2,500,000	0	0
Surrozen, Inc.	W EXP 8/11/2026	86889P117	958	833,333	SH		SOLE		833,333	0	0
Syndax Pharmaceuticals, Inc.	COM	87164F105	2,424	110,729	SH		SOLE		110,729	0	0
Talis Biomedical Corporation	COM	87424L108	30,576	7,624,835	SH		SOLE		7,624,835	0	0
Tango Therapeutics, Inc.	COM	87583X109	8,205	750,000	SH		SOLE		750,000	0	0
TCR2 Therapeutics Inc.	COM	87808K106	3,509	753,064	SH		SOLE		753,064	0	0
Travere Therapeutics, Inc.	COM	89422G107	82,847	2,669,054	SH		SOLE		2,669,054	0	0
Tricida, Inc.	COM	89610F101	12,285	1,285,014	SH		SOLE		1,285,014	0	0
TScan Therapeutics, Inc.	COM	89854M101	6,413	1,425,000	SH		SOLE		1,425,000	0	0
Ultragenyx Pharmaceutical Inc.	COM	90400D108	37,373	444,444	SH		SOLE		444,444	0	0
Verastem, Inc.	COM	92337C104	44,058	21,491,630	SH		SOLE		21,491,630	0	0
Verve Therapeutics, Inc.	COM	92539P101	52,227	1,416,530	SH		SOLE		1,416,530	0	0
Vincerx Pharma, Inc.	COM	92731L106	2,460	241,379	SH		SOLE		241,379	0	0
Xenon Pharmaceuticals Inc.	COM	98420N105	23,481	751,639	SH		SOLE		751,639	0	0
Zymeworks Inc.	COM	98985W102	28,002	1,708,472	SH		SOLE		1,708,472	0	0
Apellis Pharmaceuticals, Inc.	Note 3.5% 9/15/2026	03753UAB2	47,968	31,754,000	PRN		SOLE		31,754,000	0	0
Insmed Incorporated	Note 0.75% 6/1/2028	457669AB5	43,336	40,000,000	PRN		SOLE		40,000,000	0	0
Invitae Corporation	Note 2.0% 9/1/2024	46185LAB9	9,623	10,300,000	PRN		SOLE		10,300,000	0	0
Sarepta Therapeutics, Inc.	DBCV 1.5% 11/15/2024	803607AB6	42,695	29,174,000	PRN		SOLE		29,174,000	0	0
Tricida, Inc.	Note 3.5% 5/15/2027	89610FAB7	14,828	27,500,000	PRN		SOLE		27,500,000	0	0