Baker Bros. Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
2seventy bio, Inc.	COMMON STOCK	901384107	35,190	2,062,744	SH		SOLE		2,062,744	0	0
AbCellera Biologics Inc.	COM	00288U106	101,889	10,450,180	SH		SOLE		10,450,180	0	0
ACADIA Pharmaceuticals Inc.	COM	004225108	1,015,077	41,910,704	SH		SOLE		41,910,704	0	0
Achilles Therapeutics plc	SPONSORED ADS	00449L102	7,619	2,591,366	SH		SOLE		2,591,366	0	0
Adaptimmune Therapeutics plc	SPONSORED ADR	00653A107	20,252	9,830,877	SH		SOLE		9,830,877	0	0
Aeglea BioTherapeutics, Inc.	COM	00773J103	7,843	3,410,106	SH		SOLE		3,410,106	0	0
Aerovate Therapeutics, Inc.	COM	008064107	37,943	2,070,010	SH		SOLE		2,070,010	0	0
Affimed N.V.	COM	N01045108	22,519	5,153,169	SH		SOLE		5,153,169	0	0
Akero Therapeutics, Inc.	COM	00973Y108	1,680	118,378	SH		SOLE		118,378	0	0
Alector, Inc.	COM	014442107	3,409	239,228	SH		SOLE		239,228	0	0
Aligos Therapeutics, Inc.	COM	01626L105	4,464	2,076,400	SH		SOLE		2,076,400	0	0
Alkermes plc	SHS	G01767105	39,465	1,500,000	SH		SOLE		1,500,000	0	0
Allakos Inc.	COM	01671P100	4,007	703,050	SH		SOLE		703,050	0	0
Altimmune, Inc.	COM	02155H200	6,529	1,072,038	SH		SOLE		1,072,038	0	0
Amarin Corporation plc	SPONSORED ADR	023111206	69,649	21,169,805	SH		SOLE		21,169,805	0	0
AnaptysBio, Inc.	COM	032724106	10,568	427,179	SH		SOLE		427,179	0	0
argenx SE	SPONSORED ADR	04016X101	353,008	1,119,557	SH		SOLE		1,119,557	0	0
Ascendis Pharma A/S	SPONSORED ADR	04351P101	533,003	4,541,604	SH		SOLE		4,541,604	0	0
Athira Pharma, Inc.	COM	04746L104	10,886	806,367	SH		SOLE		806,367	0	0
Atreca, Inc.	CL A COM	04965G109	11,199	3,532,760	SH		SOLE		3,532,760	0	0
aTyr Pharma, Inc.	COM	002120202	3,344	625,000	SH		SOLE		625,000	0	0
Axsome Therapeutics, Inc.	COM	05464T104	25,288	610,970	SH		SOLE		610,970	0	0
BeiGene, Ltd.	SPONSORED ADR	07725L102	2,200,754	11,668,897	SH		SOLE		11,668,897	0	0
Bellicum Pharmaceuticals, Inc.	COM	079481404	538	249,123	SH		SOLE		249,123	0	0
BioAtla, Inc.	COM	09077B104	4,125	825,000	SH		SOLE		825,000	0	0
BioCryst Pharmaceuticals, Inc.	COM	09058V103	206,678	12,710,818	SH		SOLE		12,710,818	0	0
BioMarin Pharmaceutical Inc.	COM	09061G101	587,540	7,620,494	SH		SOLE		7,620,494	0	0
Biomea Fusion, Inc.	COM	09077A106	6,919	1,551,445	SH		SOLE		1,551,445	0	0
bluebird bio, Inc.	COM	09609G100	12,124	2,499,715	SH		SOLE		2,499,715	0	0
Burning Rock Biotech Limited	SPONSORED ADS	12233L107	1,943	209,131	SH		SOLE		209,131	0	0
Cabaletta Bio, Inc.	COM	12674W109	1,344	662,063	SH		SOLE		662,063	0	0
Centessa Pharmaceuticals plc	SPONSORED ADS	152309100	10,112	1,127,273	SH		SOLE		1,127,273	0	0
Cerus Corporation	COM	157085101	75,285	13,713,195	SH		SOLE		13,713,195	0	0
ChemoCentryx, Inc.	COM	16383L106	22,986	916,862	SH		SOLE		916,862	0	0
Chinook Therapeutics, Inc.	COM	16961L106	38,186	2,334,102	SH		SOLE		2,334,102	0	0
Crinetics Pharmaceuticals, Inc.	COM	22663K107	18,163	827,480	SH		SOLE		827,480	0	0
CymaBay Therapeutics, Inc.	COM	23257D103	6,750	2,170,464	SH		SOLE		2,170,464	0	0
Cyteir Therapeutics, Inc.	COM	23284P103	3,064	812,640	SH		SOLE		812,640	0	0
DBV Technologies S.A.	SPONSORED ADR	23306J101	23,237	14,614,264	SH		SOLE		14,614,264	0	0
Denali Therapeutics Inc.	COM	24823R105	2,855	88,738	SH		SOLE		88,738	0	0
Design Therapeutics, Inc.	COM	25056L103	23,202	1,436,636	SH		SOLE		1,436,636	0	0
DICE Therapeutics, Inc.	COM	23345J104	11,253	588,235	SH		SOLE		588,235	0	0
Edgewise Therapeutics, Inc.	COM	28036F105	4,850	500,000	SH		SOLE		500,000	0	0
Entrada Therapeutics, Inc.	COM	29384C108	44,174	4,704,419	SH		SOLE		4,704,419	0	0
Epizyme, Inc.	COM	29428V104	1,150	1,000,000	SH		SOLE		1,000,000	0	0
FibroGen, Inc.	COM	31572Q808	6,993	581,750	SH		SOLE		581,750	0	0
Foghorn Therapeutics Inc.	COM	344174107	686	45,027	SH		SOLE		45,027	0	0
Forma Therapeutics Holdings, Inc.	SHS	34633R104	18,831	2,024,876	SH		SOLE		2,024,876	0	0
Fulgent Genetics, Inc.	COM	359664109	12,572	201,444	SH		SOLE		201,444	0	0
Genetron Holdings Limited	ADS	37186H100	997	455,306	SH		SOLE		455,306	0	0
Global Blood Therapeutics, Inc.	COM	37890U108	114,823	3,314,765	SH		SOLE		3,314,765	0	0
Harmony Biosciences Holdings, Inc.	COM	413197104	6,013	123,600	SH		SOLE		123,600	0	0
Heron Therapeutics, Inc.	COM	427746102	46,513	8,131,678	SH		SOLE		8,131,678	0	0
HOOKIPA Pharma Inc.	COM	43906K100	5,473	2,400,481	SH		SOLE		2,400,481	0	0
Horizon Therapeutics Public Ltd Co	SHS	G46188101	94,567	898,842	SH		SOLE		898,842	0	0
IGM Biosciences, Inc.	COM	449585108	84,363	3,156,102	SH		SOLE		3,156,102	0	0
Immatics N.V.	SHS	N44445109	35,346	4,423,731	SH		SOLE		4,423,731	0	0
Immunocore Holdings plc	ADS	45258D105	75,370	2,520,730	SH		SOLE		2,520,730	0	0
Incyte Corporation	COM	45337C102	2,871,326	36,153,684	SH		SOLE		36,153,684	0	0
Inozyme Pharma, Inc.	COM	45790W108	438	106,999	SH		SOLE		106,999	0	0
Insmed Incorporated	COM PAR $.01	457669307	50,666	2,156,001	SH		SOLE		2,156,001	0	0
Instil Bio, Inc.	COM	45783C101	41,857	3,893,700	SH		SOLE		3,893,700	0	0
Invitae Corporation	COM	46185L103	78,692	9,873,488	SH		SOLE		9,873,488	0	0
Iteos Therapeutics, Inc.	COM	46565G104	4,838	150,346	SH		SOLE		150,346	0	0
Karuna Therapeutics, Inc.	COM	48576A100	8,871	69,966	SH		SOLE		69,966	0	0
Kezar Life Sciences, Inc.	COM	49372L100	2,321	139,676	SH		SOLE		139,676	0	0
Kiniksa Pharmaceuticals, Ltd.	COM CL A	G5269C101	27,828	2,799,577	SH		SOLE		2,799,577	0	0
Kodiak Sciences Inc.	COM	50015M109	122,988	15,931,045	SH		SOLE		15,931,045	0	0
Krystal Biotech, Inc.	COM	501147102	53,747	807,735	SH		SOLE		807,735	0	0
Kura Oncology, Inc.	COM	50127T109	4,413	274,458	SH		SOLE		274,458	0	0
Kymera Therapeutics, Inc.	COM	501575104	100,922	2,384,742	SH		SOLE		2,384,742	0	0
Leap Therapeutics, Inc.	COM	52187K101	979	559,705	SH		SOLE		559,705	0	0
Legend Biotech Corporation	SPONSORED ADS	52490G102	73,007	2,008,999	SH		SOLE		2,008,999	0	0
LogicBio Therapeutics, Inc.	COM	54142F102	307	451,478	SH		SOLE		451,478	0	0
MacroGenics, Inc.	COM	556099109	3,899	442,579	SH		SOLE		442,579	0	0
Madrigal Pharmaceuticals, Inc.	COM	558868105	147,103	1,499,213	SH		SOLE		1,499,213	0	0
Merus N.V.	COM	N5749R100	53,871	2,037,469	SH		SOLE		2,037,469	0	0
Mirati Therapeutics, Inc.	COM	60468T105	115,912	1,409,784	SH		SOLE		1,409,784	0	0
Neoleukin Therapeutics, Inc.	COM	64049K104	7,185	3,821,740	SH		SOLE		3,821,740	0	0
Neurocrine Biosciences, Inc.	COM	64125C109	63,466	676,975	SH		SOLE		676,975	0	0
NexImmune, Inc.	COM	65344D109	1,238	294,117	SH		SOLE		294,117	0	0
NGM Biopharmaceuticals, Inc.	COM	62921N105	4,450	291,801	SH		SOLE		291,801	0	0
Novavax, Inc.	COM	670002401	3,548	48,168	SH		SOLE		48,168	0	0
Nurix Therapeutics, Inc.	COM	67080M103	34,382	2,454,082	SH		SOLE		2,454,082	0	0
Opthea Limited	SPONSORED ADS	68386J208	18,485	2,696,191	SH		SOLE		2,696,191	0	0
Otonomy, Inc.	COM	68906L105	18,827	7,844,692	SH		SOLE		7,844,692	0	0
Oyster Point Pharma, Inc.	COM	69242L106	715	61,424	SH		SOLE		61,424	0	0
Pacific Biosciences of California, Inc.	COM	69404D108	49,549	5,444,963	SH		SOLE		5,444,963	0	0
Passage Bio, Inc.	COM	702712100	363	117,161	SH		SOLE		117,161	0	0
Prelude Therapeutics Inc.	COM	74065P101	69,854	10,123,824	SH		SOLE		10,123,824	0	0
Protara Therapeutics, Inc.	COM STK	74365U107	1,020	199,671	SH		SOLE		199,671	0	0
Reata Pharmaceuticals, Inc.	CL A	75615P103	7,337	223,976	SH		SOLE		223,976	0	0
Relmada Therapeutics, Inc.	COM	75955J402	13,363	495,113	SH		SOLE		495,113	0	0
Replimune Group, Inc.	COM	76029N106	27,367	1,611,703	SH		SOLE		1,611,703	0	0
Revolution Medicines, Inc.	COM	76155X100	5,669	222,222	SH		SOLE		222,222	0	0
Rhythm Pharmaceuticals, Inc.	COM	76243J105	47,521	4,125,062	SH		SOLE		4,125,062	0	0
Sarepta Therapeutics, Inc.	COM	803607100	9,644	123,456	SH		SOLE		123,456	0	0
Seagen Inc.	COM	81181C104	6,757,712	46,912,266	SH		SOLE		46,912,266	0	0
Sera Prognostics, Inc.	CLASS A COM	81749D107	764	201,562	SH		SOLE		201,562	0	0
Surrozen, Inc.	COM	86889P109	7,525	2,500,000	SH		SOLE		2,500,000	0	0
Surrozen, Inc.	W EXP 8/11/2026	86889P117	208	833,333	SH		SOLE		833,333	0	0
Syndax Pharmaceuticals, Inc.	COM	87164F105	1,924	110,729	SH		SOLE		110,729	0	0
Talis Biomedical Corporation	COM	87424L108	10,751	7,624,835	SH		SOLE		7,624,835	0	0
Tango Therapeutics, Inc.	COM	87583X109	5,685	750,000	SH		SOLE		750,000	0	0
TCR2 Therapeutics Inc.	COM	87808K106	2,078	753,064	SH		SOLE		753,064	0	0
Travere Therapeutics, Inc.	COM	89422G107	85,041	3,300,009	SH		SOLE		3,300,009	0	0
Tricida, Inc.	COM	89610F101	14,235	1,731,714	SH		SOLE		1,731,714	0	0
TScan Therapeutics, Inc.	COM	89854M101	3,990	1,425,000	SH		SOLE		1,425,000	0	0
Ultragenyx Pharmaceutical Inc.	COM	90400D108	32,276	444,444	SH		SOLE		444,444	0	0
Vera Therapeutics, Inc.	CL A	92337R101	7,830	333,333	SH		SOLE		333,333	0	0
Verastem, Inc.	COM	92337C104	38,054	26,988,898	SH		SOLE		26,988,898	0	0
Verve Therapeutics, Inc.	COM	92539P101	32,325	1,416,530	SH		SOLE		1,416,530	0	0
Vincerx Pharma, Inc.	COM	92731L106	966	241,379	SH		SOLE		241,379	0	0
Xenon Pharmaceuticals Inc.	COM	98420N105	22,978	751,639	SH		SOLE		751,639	0	0
Zymeworks Inc.	COM	98985W102	11,190	1,708,472	SH		SOLE		1,708,472	0	0
Insmed Incorporated	Note 0.75% 6/1/2028	457669AB5	38,614	40,000,000	PRN		SOLE		40,000,000	0	0
Invitae Corporation	Note 2.0% 9/1/2024	46185LAB9	8,379	10,300,000	PRN		SOLE		10,300,000	0	0
Sarepta Therapeutics, Inc.	DBCV 1.5% 11/15/2024	803607AB6	38,359	29,174,000	PRN		SOLE		29,174,000	0	0