Baker Bros. Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
2seventy bio, Inc.	COMMON STOCK	901384107	27,228	2,062,744	SH		SOLE		2,062,744	0	0
AbCellera Biologics Inc.	COM	00288U106	111,294	10,450,180	SH		SOLE		10,450,180	0	0
ACADIA Pharmaceuticals Inc.	COM	004225108	590,702	41,923,486	SH		SOLE		41,923,486	0	0
Achilles Therapeutics plc	SPONSORED ADS	00449L102	6,530	2,591,366	SH		SOLE		2,591,366	0	0
Adaptimmune Therapeutics plc	SPONSORED ADR	00653A107	16,712	9,830,877	SH		SOLE		9,830,877	0	0
Aeglea BioTherapeutics, Inc.	COM	00773J103	1,722	3,410,106	SH		SOLE		3,410,106	0	0
Aerovate Therapeutics, Inc.	COM	008064107	32,354	2,070,010	SH		SOLE		2,070,010	0	0
Affimed N.V.	COM	N01045108	18,273	6,596,830	SH		SOLE		6,596,830	0	0
Akero Therapeutics, Inc.	COM	00973Y108	1,119	118,378	SH		SOLE		118,378	0	0
Alector, Inc.	COM	014442107	2,431	239,228	SH		SOLE		239,228	0	0
Aligos Therapeutics, Inc.	COM	01626L105	2,512	2,076,400	SH		SOLE		2,076,400	0	0
Alkermes plc	SHS	G01767105	44,685	1,500,000	SH		SOLE		1,500,000	0	0
Allakos Inc.	COM	01671P100	2,201	703,050	SH		SOLE		703,050	0	0
Altimmune, Inc.	COM	02155H200	24,282	2,075,403	SH		SOLE		2,075,403	0	0
Amarin Corporation plc	SPONSORED ADR	023111206	31,543	21,169,805	SH		SOLE		21,169,805	0	0
AnaptysBio, Inc.	COM	032724106	8,672	427,179	SH		SOLE		427,179	0	0
argenx SE	SPONSORED ADR	04016X101	424,178	1,119,557	SH		SOLE		1,119,557	0	0
Ascendis Pharma A/S	SPONSORED ADR	04351P101	451,103	4,852,655	SH		SOLE		4,852,655	0	0
Atara Biotherapeutics, Inc.	COM	046513107	5,797	744,186	SH		SOLE		744,186	0	0
Athira Pharma, Inc.	COM	04746L104	3,175	1,040,834	SH		SOLE		1,040,834	0	0
Atreca, Inc.	CL A COM	04965G109	6,324	3,532,760	SH		SOLE		3,532,760	0	0
aTyr Pharma, Inc.	COM	002120202	1,060	374,395	SH		SOLE		374,395	0	0
BeiGene, Ltd.	SPONSORED ADR	07725L102	1,888,611	11,668,897	SH		SOLE		11,668,897	0	0
Bellicum Pharmaceuticals, Inc.	COM	079481404	296	249,123	SH		SOLE		249,123	0	0
BioAtla, Inc.	COM	09077B104	2,351	825,000	SH		SOLE		825,000	0	0
BioCryst Pharmaceuticals, Inc.	COM	09058V103	134,480	12,710,818	SH		SOLE		12,710,818	0	0
BioMarin Pharmaceutical Inc.	COM	09061G101	631,510	7,620,494	SH		SOLE		7,620,494	0	0
Biomea Fusion, Inc.	COM	09077A106	25,213	2,104,559	SH		SOLE		2,104,559	0	0
bluebird bio, Inc.	COM	09609G100	10,349	2,499,715	SH		SOLE		2,499,715	0	0
Burning Rock Biotech Limited	SPONSORED ADS	12233L107	609	209,131	SH		SOLE		209,131	0	0
Cabaletta Bio, Inc.	COM	12674W109	702	662,063	SH		SOLE		662,063	0	0
Centessa Pharmaceuticals plc	SPONSORED ADS	152309100	5,490	1,127,273	SH		SOLE		1,127,273	0	0
Cerus Corporation	COM	157085101	84,997	16,067,558	SH		SOLE		16,067,558	0	0
ChemoCentryx, Inc.	COM	16383L106	44,422	1,792,657	SH		SOLE		1,792,657	0	0
Chinook Therapeutics, Inc.	COM	16961L106	44,321	2,534,102	SH		SOLE		2,534,102	0	0
Crinetics Pharmaceuticals, Inc.	COM	22663K107	15,433	827,480	SH		SOLE		827,480	0	0
CymaBay Therapeutics, Inc.	COM	23257D103	6,403	2,170,464	SH		SOLE		2,170,464	0	0
Cyteir Therapeutics, Inc.	COM	23284P103	7,904	2,643,640	SH		SOLE		2,643,640	0	0
DBV Technologies S.A.	SPONSORED ADR	23306J101	37,266	14,614,264	SH		SOLE		14,614,264	0	0
Denali Therapeutics Inc.	COM	24823R105	17,327	588,738	SH		SOLE		588,738	0	0
Design Therapeutics, Inc.	COM	25056L103	20,113	1,436,636	SH		SOLE		1,436,636	0	0
DICE Therapeutics, Inc.	COM	23345J104	9,129	588,235	SH		SOLE		588,235	0	0
Edgewise Therapeutics, Inc.	COM	28036F105	3,980	500,000	SH		SOLE		500,000	0	0
Entrada Therapeutics, Inc.	COM	29384C108	59,266	4,865,819	SH		SOLE		4,865,819	0	0
Epizyme, Inc.	COM	29428V104	1,470	1,000,000	SH		SOLE		1,000,000	0	0
Evofem Biosciences, Inc.	COM	30048L203	2,919	2,583,616	SH		SOLE		2,583,616	0	0
FibroGen, Inc.	COM	31572Q808	8,614	815,718	SH		SOLE		815,718	0	0
Foghorn Therapeutics Inc.	COM	344174107	612	45,027	SH		SOLE		45,027	0	0
Forma Therapeutics Holdings, Inc.	SHS	34633R104	13,951	2,024,876	SH		SOLE		2,024,876	0	0
Fulgent Genetics, Inc.	COM	359664109	10,985	201,444	SH		SOLE		201,444	0	0
Genetron Holdings Limited	ADS	37186H100	774	455,306	SH		SOLE		455,306	0	0
Global Blood Therapeutics, Inc.	COM	37890U108	119,253	3,732,502	SH		SOLE		3,732,502	0	0
Harmony Biosciences Holdings, Inc.	COM	413197104	6,028	123,600	SH		SOLE		123,600	0	0
Heron Therapeutics, Inc.	COM	427746102	22,687	8,131,678	SH		SOLE		8,131,678	0	0
HOOKIPA Pharma Inc.	COM	43906K100	3,913	2,400,481	SH		SOLE		2,400,481	0	0
Horizon Therapeutics Public Ltd Co	SHS	G46188101	91,605	1,148,504	SH		SOLE		1,148,504	0	0
IGM Biosciences, Inc.	COM	449585108	56,905	3,156,102	SH		SOLE		3,156,102	0	0
Immatics N.V.	SHS	N44445109	38,531	4,423,731	SH		SOLE		4,423,731	0	0
Immunocore Holdings plc	ADS	45258D105	94,048	2,520,730	SH		SOLE		2,520,730	0	0
Incyte Corporation	COM	45337C102	2,746,628	36,154,117	SH		SOLE		36,154,117	0	0
Inozyme Pharma, Inc.	COM	45790W108	510	106,999	SH		SOLE		106,999	0	0
Insmed Incorporated	COM PAR $.01	457669307	42,516	2,156,001	SH		SOLE		2,156,001	0	0
Instil Bio, Inc.	COM	45783C101	17,989	3,893,700	SH		SOLE		3,893,700	0	0
Invitae Corporation	COM	46185L103	24,091	9,873,488	SH		SOLE		9,873,488	0	0
iTeos Therapeutics, Inc.	COM	46565G104	3,097	150,346	SH		SOLE		150,346	0	0
Karuna Therapeutics, Inc.	COM	48576A100	8,851	69,966	SH		SOLE		69,966	0	0
Kezar Life Sciences, Inc.	COM	49372L100	512	61,946	SH		SOLE		61,946	0	0
Kiniksa Pharmaceuticals, Ltd.	COM CL A	G5269C101	27,128	2,799,577	SH		SOLE		2,799,577	0	0
Kodiak Sciences Inc.	COM	50015M109	132,252	17,310,490	SH		SOLE		17,310,490	0	0
Krystal Biotech, Inc.	COM	501147102	53,036	807,735	SH		SOLE		807,735	0	0
Kymera Therapeutics, Inc.	COM	501575104	56,704	2,879,825	SH		SOLE		2,879,825	0	0
Leap Therapeutics, Inc.	COM	52187K101	644	559,705	SH		SOLE		559,705	0	0
Legend Biotech Corporation	SPONSORED ADS	52490G102	47,116	856,658	SH		SOLE		856,658	0	0
LogicBio Therapeutics, Inc.	COM	54142F102	158	451,478	SH		SOLE		451,478	0	0
MacroGenics, Inc.	COM	556099109	2,633	892,579	SH		SOLE		892,579	0	0
Madrigal Pharmaceuticals, Inc.	COM	558868105	107,314	1,499,213	SH		SOLE		1,499,213	0	0
Merus N.V.	COM	N5749R100	22,536	995,397	SH		SOLE		995,397	0	0
Mirati Therapeutics, Inc.	COM	60468T105	94,639	1,409,784	SH		SOLE		1,409,784	0	0
Natera, Inc.	COM	632307104	3,544	100,000	SH		SOLE		100,000	0	0
Neoleukin Therapeutics, Inc.	COM	64049K104	3,936	3,821,740	SH		SOLE		3,821,740	0	0
NexImmune, Inc.	COM	65344D109	32	20,000	SH		SOLE		20,000	0	0
NGM Biopharmaceuticals, Inc.	COM	62921N105	709	55,294	SH		SOLE		55,294	0	0
Nkarta, Inc.	COM	65487U108	4,928	400,000	SH		SOLE		400,000	0	0
Nurix Therapeutics, Inc.	COM	67080M103	49,187	3,882,125	SH		SOLE		3,882,125	0	0
Opthea Limited	SPONSORED ADS	68386J208	16,986	2,696,191	SH		SOLE		2,696,191	0	0
Otonomy, Inc.	COM	68906L105	17,498	8,412,634	SH		SOLE		8,412,634	0	0
Pacific Biosciences of California, Inc.	COM	69404D108	24,067	5,444,963	SH		SOLE		5,444,963	0	0
Passage Bio, Inc.	COM	702712100	276	117,161	SH		SOLE		117,161	0	0
Prelude Therapeutics Inc.	COM	74065P101	52,846	10,123,824	SH		SOLE		10,123,824	0	0
Protara Therapeutics, Inc.	COM STK	74365U107	585	199,671	SH		SOLE		199,671	0	0
Reata Pharmaceuticals, Inc.	CL A	75615P103	6,807	223,976	SH		SOLE		223,976	0	0
Relmada Therapeutics, Inc.	COM	75955J402	9,402	495,113	SH		SOLE		495,113	0	0
Replimune Group, Inc.	COM	76029N106	62,772	3,591,081	SH		SOLE		3,591,081	0	0
Revolution Medicines, Inc.	COM	76155X100	4,331	222,222	SH		SOLE		222,222	0	0
Rhythm Pharmaceuticals, Inc.	COM	76243J105	17,119	4,125,062	SH		SOLE		4,125,062	0	0
Seagen Inc.	COM	81181C104	8,300,656	46,912,266	SH		SOLE		46,912,266	0	0
Sera Prognostics, Inc.	CLASS A COM	81749D107	331	201,562	SH		SOLE		201,562	0	0
Surrozen, Inc.	COM	86889P109	7,500	2,500,000	SH		SOLE		2,500,000	0	0
Surrozen, Inc.	W EXP 8/11/2026	86889P117	159	833,333	SH		SOLE		833,333	0	0
Syndax Pharmaceuticals, Inc.	COM	87164F105	2,130	110,729	SH		SOLE		110,729	0	0
Talis Biomedical Corporation	COM	87424L108	6,191	7,624,835	SH		SOLE		7,624,835	0	0
Tango Therapeutics, Inc.	COM	87583X109	3,398	750,000	SH		SOLE		750,000	0	0
TCR2 Therapeutics Inc.	COM	87808K106	2,184	753,064	SH		SOLE		753,064	0	0
Travere Therapeutics, Inc.	COM	89422G107	79,959	3,300,009	SH		SOLE		3,300,009	0	0
Tricida, Inc.	COM	89610F101	14,550	1,503,090	SH		SOLE		1,503,090	0	0
TScan Therapeutics, Inc.	COM	89854M101	8,758	2,784,792	SH		SOLE		2,784,792	0	0
Ultragenyx Pharmaceutical Inc.	COM	90400D108	28,098	470,974	SH		SOLE		470,974	0	0
Vera Therapeutics, Inc.	CL A	92337R101	4,537	333,333	SH		SOLE		333,333	0	0
Verastem, Inc.	COM	92337C104	31,307	26,988,898	SH		SOLE		26,988,898	0	0
Verve Therapeutics, Inc.	COM	92539P101	21,645	1,416,530	SH		SOLE		1,416,530	0	0
Vincerx Pharma, Inc.	COM	92731L106	319	241,379	SH		SOLE		241,379	0	0
Vor Biopharma Inc.	COM	929033108	5,660	1,138,768	SH		SOLE		1,138,768	0	0
Xenon Pharmaceuticals Inc.	COM	98420N105	22,865	751,639	SH		SOLE		751,639	0	0
Zymeworks Inc.	COM	98985W102	9,055	1,708,472	SH		SOLE		1,708,472	0	0
Insmed Incorporated	Note 0.75% 6/1/2028	457669AB5	33,278	40,000,000	PRN		SOLE		40,000,000	0	0
Invitae Corporation	Note 2.0% 9/1/2024	46185LAB9	8,087	10,300,000	PRN		SOLE		10,300,000	0	0
Sarepta Therapeutics, Inc.	DBCV 1.5% 11/15/2024	803607AB6	36,577	29,174,000	PRN		SOLE		29,174,000	0	0