Baker Bros. Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
2seventy bio, Inc.	COM	901384107	30,013	2,062,744	SH		SOLE		2,062,744	0	0
Aadi Bioscience, Inc.	COM	00032Q104	13,988	989,928	SH		SOLE		989,928	0	0
AbCellera Biologics Inc.	COM	00288U106	103,352	10,450,180	SH		SOLE		10,450,180	0	0
ACADIA Pharmaceuticals Inc.	COM	004225108	685,868	41,923,486	SH		SOLE		41,923,486	0	0
Achilles Therapeutics plc	SPONSORED ADS	00449L102	5,856	2,591,366	SH		SOLE		2,591,366	0	0
Adaptimmune Therapeutics plc	SPONSORED ADR	00653A107	10,568	9,830,877	SH		SOLE		9,830,877	0	0
Aeglea BioTherapeutics, Inc.	COM	00773J103	1,794	3,410,106	SH		SOLE		3,410,106	0	0
Aerovate Therapeutics, Inc.	COM	008064107	32,821	1,979,568	SH		SOLE		1,979,568	0	0
Affimed N.V.	COM	N01045108	13,589	6,596,830	SH		SOLE		6,596,830	0	0
Akero Therapeutics, Inc.	COM	00973Y108	80,643	2,368,378	SH		SOLE		2,368,378	0	0
Alector, Inc.	COM	014442107	2,263	239,228	SH		SOLE		239,228	0	0
Aligos Therapeutics, Inc.	COM	01626L105	2,284	2,076,400	SH		SOLE		2,076,400	0	0
Alkermes plc	SHS	G01767105	18,199	815,016	SH		SOLE		815,016	0	0
Allakos Inc.	COM	01671P100	4,303	703,050	SH		SOLE		703,050	0	0
Altimmune, Inc.	COM	02155H200	22,599	1,769,681	SH		SOLE		1,769,681	0	0
Amarin Corporation plc	SPONSORED ADR	023111206	5,861	5,377,113	SH		SOLE		5,377,113	0	0
AnaptysBio, Inc.	COM	032724106	10,897	427,179	SH		SOLE		427,179	0	0
argenx SE	SPONSORED ADR	04016X101	98,910	280,159	SH		SOLE		280,159	0	0
Ascendis Pharma A/S	SPONSORED ADR	04351P101	501,085	4,852,655	SH		SOLE		4,852,655	0	0
Atara Biotherapeutics, Inc.	COM	046513107	2,813	744,186	SH		SOLE		744,186	0	0
Athira Pharma, Inc.	COM	04746L104	3,091	1,040,834	SH		SOLE		1,040,834	0	0
Atreca, Inc.	CL A COM	04965G109	5,546	3,532,760	SH		SOLE		3,532,760	0	0
aTyr Pharma, Inc.	COM	002120202	604	201,361	SH		SOLE		201,361	0	0
BeiGene, Ltd.	SPONSORED ADR	07725L102	1,573,201	11,668,897	SH		SOLE		11,668,897	0	0
Bellicum Pharmaceuticals, Inc.	COM	079481404	299	249,123	SH		SOLE		249,123	0	0
Bicycle Therapeutics plc	SPONSORED ADS	088786108	19,627	843,814	SH		SOLE		843,814	0	0
BioCryst Pharmaceuticals, Inc.	COM	09058V103	160,156	12,710,818	SH		SOLE		12,710,818	0	0
BioMarin Pharmaceutical Inc.	COM	09061G101	645,989	7,620,494	SH		SOLE		7,620,494	0	0
Biomea Fusion, Inc.	COM	09077A106	20,583	2,104,559	SH		SOLE		2,104,559	0	0
bluebird bio, Inc.	COM	09609G100	15,823	2,499,715	SH		SOLE		2,499,715	0	0
Cabaletta Bio, Inc.	COM	12674W109	430	662,063	SH		SOLE		662,063	0	0
Century Therapeutics, Inc.	COM	15673T100	3,665	370,587	SH		SOLE		370,587	0	0
Cerus Corporation	COM	157085101	57,843	16,067,558	SH		SOLE		16,067,558	0	0
ChemoCentryx, Inc.	COM	16383L106	92,609	1,792,657	SH		SOLE		1,792,657	0	0
Chinook Therapeutics, Inc.	COM	16961L106	49,820	2,534,102	SH		SOLE		2,534,102	0	0
CinCor Pharma, Inc.	COM	17240Y109	26,493	807,212	SH		SOLE		807,212	0	0
Crinetics Pharmaceuticals, Inc.	COM	22663K107	14,449	735,716	SH		SOLE		735,716	0	0
CymaBay Therapeutics, Inc.	COM	23257D103	7,597	2,170,464	SH		SOLE		2,170,464	0	0
Cyteir Therapeutics, Inc.	COM	23284P103	5,076	2,643,640	SH		SOLE		2,643,640	0	0
DBV Technologies S.A.	SPONSORED ADR	23306J101	25,867	14,614,264	SH		SOLE		14,614,264	0	0
Denali Therapeutics Inc.	COM	24823R105	18,068	588,738	SH		SOLE		588,738	0	0
Design Therapeutics, Inc.	COM	25056L103	24,021	1,436,636	SH		SOLE		1,436,636	0	0
DICE Therapeutics, Inc.	COM	23345J104	11,929	588,235	SH		SOLE		588,235	0	0
Edgewise Therapeutics, Inc.	COM	28036F105	4,920	500,000	SH		SOLE		500,000	0	0
Eiger BioPharmaceuticals, Inc.	COM	28249U105	4,065	539,851	SH		SOLE		539,851	0	0
Entrada Therapeutics, Inc.	COM	29384C108	76,685	4,865,819	SH		SOLE		4,865,819	0	0
Fate Therapeutics, Inc.	COM	31189P102	4,834	215,695	SH		SOLE		215,695	0	0
FibroGen, Inc.	COM	31572Q808	10,612	815,718	SH		SOLE		815,718	0	0
Foghorn Therapeutics Inc.	COM	344174107	386	45,027	SH		SOLE		45,027	0	0
Forma Therapeutics Holdings, Inc.	SHS	34633R104	37,641	1,886,760	SH		SOLE		1,886,760	0	0
Fulgent Genetics, Inc.	COM	359664109	6,352	166,619	SH		SOLE		166,619	0	0
Genetron Holdings Limited	ADS	37186H100	356	455,306	SH		SOLE		455,306	0	0
Global Blood Therapeutics, Inc.	COM	37890U108	254,183	3,732,502	SH		SOLE		3,732,502	0	0
Heron Therapeutics, Inc.	COM	427746102	34,316	8,131,678	SH		SOLE		8,131,678	0	0
HOOKIPA Pharma Inc.	COM	43906K100	3,217	2,400,481	SH		SOLE		2,400,481	0	0
Horizon Therapeutics Public Ltd Co	SHS	G46188101	60,016	969,727	SH		SOLE		969,727	0	0
IDEAYA Biosciences, Inc.	COM	45166A102	24,892	1,668,355	SH		SOLE		1,668,355	0	0
IGM Biosciences, Inc.	COM	449585108	71,770	3,156,102	SH		SOLE		3,156,102	0	0
Immatics N.V.	SHS	N44445109	44,237	4,423,731	SH		SOLE		4,423,731	0	0
Immunocore Holdings plc	ADS	45258D105	118,323	2,520,731	SH		SOLE		2,520,731	0	0
Incyte Corporation	COM	45337C102	2,409,341	36,154,574	SH		SOLE		36,154,574	0	0
Insmed Incorporated	COM PAR $.01	457669307	430	19,950	SH		SOLE		19,950	0	0
Instil Bio, Inc.	COM	45783C101	18,846	3,893,700	SH		SOLE		3,893,700	0	0
Invitae Corporation	COM	46185L103	20,669	8,402,035	SH		SOLE		8,402,035	0	0
iTeos Therapeutics, Inc.	COM	46565G104	2,864	150,346	SH		SOLE		150,346	0	0
Kezar Life Sciences, Inc.	COM	49372L100	533	61,946	SH		SOLE		61,946	0	0
Kiniksa Pharmaceuticals, Ltd.	COM CL A	G5269C101	35,947	2,799,577	SH		SOLE		2,799,577	0	0
Kodiak Sciences Inc.	COM	50015M109	133,983	17,310,490	SH		SOLE		17,310,490	0	0
Kronos Bio, Inc.	COM	50107A104	5,158	1,539,616	SH		SOLE		1,539,616	0	0
Krystal Biotech, Inc.	COM	501147102	29,426	422,185	SH		SOLE		422,185	0	0
Kymera Therapeutics, Inc.	COM	501575104	62,694	2,879,825	SH		SOLE		2,879,825	0	0
Leap Therapeutics, Inc.	COM	52187K101	493	559,705	SH		SOLE		559,705	0	0
LogicBio Therapeutics, Inc.	COM	54142F102	38	139,105	SH		SOLE		139,105	0	0
MacroGenics, Inc.	COM	556099109	3,088	892,579	SH		SOLE		892,579	0	0
Madrigal Pharmaceuticals, Inc.	COM	558868105	97,434	1,499,213	SH		SOLE		1,499,213	0	0
Mirati Therapeutics, Inc.	COM	60468T105	98,459	1,409,784	SH		SOLE		1,409,784	0	0
Natera, Inc.	COM	632307104	4,382	100,000	SH		SOLE		100,000	0	0
Neoleukin Therapeutics, Inc.	COM	64049K104	2,446	3,821,740	SH		SOLE		3,821,740	0	0
Nkarta, Inc.	COM	65487U108	5,264	400,000	SH		SOLE		400,000	0	0
Nurix Therapeutics, Inc.	COM	67080M103	50,584	3,882,125	SH		SOLE		3,882,125	0	0
Opthea Limited	SPONSORED ADS	68386J208	16,687	2,691,391	SH		SOLE		2,691,391	0	0
Otonomy, Inc.	COM	68906L105	2,491	8,443,134	SH		SOLE		8,443,134	0	0
Pacific Biosciences of California, Inc.	COM	69404D108	6,547	1,127,782	SH		SOLE		1,127,782	0	0
PMV Pharmaceuticals, Inc.	COM	69353Y103	3,832	322,024	SH		SOLE		322,024	0	0
POINT Biopharma Global Inc.	COM	730541109	9,037	1,169,103	SH		SOLE		1,169,103	0	0
Prelude Therapeutics Inc.	COM	74065P101	66,918	10,123,824	SH		SOLE		10,123,824	0	0
Protara Therapeutics, Inc.	COM STK	74365U107	591	199,671	SH		SOLE		199,671	0	0
Reata Pharmaceuticals, Inc.	CL A	75615P103	5,629	223,976	SH		SOLE		223,976	0	0
Relmada Therapeutics, Inc.	COM	75955J402	18,329	495,113	SH		SOLE		495,113	0	0
Replimune Group, Inc.	COM	76029N106	67,247	3,893,843	SH		SOLE		3,893,843	0	0
Revolution Medicines, Inc.	COM	76155X100	4,382	222,222	SH		SOLE		222,222	0	0
Rhythm Pharmaceuticals, Inc.	COM	76243J105	148,536	6,062,702	SH		SOLE		6,062,702	0	0
Seagen Inc.	COM	81181C104	6,419,005	46,912,266	SH		SOLE		46,912,266	0	0
Sera Prognostics, Inc.	CLASS A COM	81749D107	322	201,562	SH		SOLE		201,562	0	0
Stoke Therapeutics, Inc.	COM	86150R107	4,742	369,327	SH		SOLE		369,327	0	0
Surrozen, Inc.	COM	86889P109	5,050	2,500,000	SH		SOLE		2,500,000	0	0
Surrozen, Inc.	W EXP 8/11/2026	86889P117	154	833,333	SH		SOLE		833,333	0	0
Syndax Pharmaceuticals, Inc.	COM	87164F105	2,661	110,729	SH		SOLE		110,729	0	0
Talis Biomedical Corporation	COM	87424L108	5,197	7,624,835	SH		SOLE		7,624,835	0	0
Tango Therapeutics, Inc.	COM	87583X109	2,715	750,000	SH		SOLE		750,000	0	0
TCR2 Therapeutics Inc.	COM	87808K106	1,356	753,064	SH		SOLE		753,064	0	0
Travere Therapeutics, Inc.	COM	89422G107	81,312	3,300,009	SH		SOLE		3,300,009	0	0
Tricida, Inc.	COM	89610F101	13,837	1,320,290	SH		SOLE		1,320,290	0	0
TScan Therapeutics, Inc.	COM	89854M101	8,494	2,784,792	SH		SOLE		2,784,792	0	0
Ultragenyx Pharmaceutical Inc.	COM	90400D108	19,503	470,974	SH		SOLE		470,974	0	0
Vera Therapeutics, Inc.	CL A	92337R101	7,103	333,333	SH		SOLE		333,333	0	0
Verastem, Inc.	COM	92337C104	22,941	26,988,898	SH		SOLE		26,988,898	0	0
Verve Therapeutics, Inc.	COM	92539P101	48,658	1,416,530	SH		SOLE		1,416,530	0	0
Veru Inc.	COM	92536C103	18,542	1,609,579	SH		SOLE		1,609,579	0	0
Vincerx Pharma, Inc.	COM	92731L106	333	241,379	SH		SOLE		241,379	0	0
Vor Biopharma Inc.	COM	929033108	5,834	1,465,925	SH		SOLE		1,465,925	0	0
Xenon Pharmaceuticals Inc.	COM	98420N105	27,134	751,639	SH		SOLE		751,639	0	0
Zymeworks Inc.	COM	98985W102	10,507	1,708,472	SH		SOLE		1,708,472	0	0
Insmed Incorporated	Note 0.75% 6/1/2028	457669AB5	36,296	40,000,000	PRN		SOLE		40,000,000	0	0
Invitae Corporation	Note 2.0% 9/1/2024	46185LAB9	8,148	10,300,000	PRN		SOLE		10,300,000	0	0