| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 2seventy bio, Inc. | COMMON STOCK | 901384107 | 25,274,963 | 2,497,526 | SH | | SOLE | | 2,497,526 | 0 | 0 |
| Aadi Bioscience, Inc. | COM | 00032Q104 | 6,771,108 | 989,928 | SH | | SOLE | | 989,928 | 0 | 0 |
| AbCellera Biologics Inc. | COM | 00288U106 | 106,268,163 | 16,450,180 | SH | | SOLE | | 16,450,180 | 0 | 0 |
| ACADIA Pharmaceuticals Inc. | COM | 004225108 | 1,026,607,457 | 42,864,612 | SH | | SOLE | | 42,864,612 | 0 | 0 |
| Achilles Therapeutics plc | SPONSORED ADS | 00449L102 | 2,417,017 | 2,557,149 | SH | | SOLE | | 2,557,149 | 0 | 0 |
| Adaptimmune Therapeutics plc | SPONSORED ADR | 00653A107 | 10,146,586 | 10,969,282 | SH | | SOLE | | 10,969,282 | 0 | 0 |
| Aeglea BioTherapeutics, Inc. | COM | 00773J103 | 1,536,253 | 3,410,106 | SH | | SOLE | | 3,410,106 | 0 | 0 |
| Aerovate Therapeutics, Inc. | COM | 008064107 | 33,673,665 | 1,963,479 | SH | | SOLE | | 1,963,479 | 0 | 0 |
| Affimed N.V. | COM | N01045108 | 3,946,224 | 6,596,830 | SH | | SOLE | | 6,596,830 | 0 | 0 |
| Akero Therapeutics, Inc. | COM | 00973Y108 | 110,579,569 | 2,368,378 | SH | | SOLE | | 2,368,378 | 0 | 0 |
| Alector, Inc. | COM | 014442107 | 5,798,755 | 964,851 | SH | | SOLE | | 964,851 | 0 | 0 |
| Aligos Therapeutics, Inc. | COM | 01626L105 | 2,016,184 | 2,076,400 | SH | | SOLE | | 2,076,400 | 0 | 0 |
| Allogene Therapeutics, Inc. | COM | 019770106 | 7,837,198 | 1,576,901 | SH | | SOLE | | 1,576,901 | 0 | 0 |
| AnaptysBio, Inc. | COM | 032724106 | 15,782,294 | 775,924 | SH | | SOLE | | 775,924 | 0 | 0 |
| Aravive, Inc. | COM | 03890D108 | 4,109,142 | 3,261,224 | SH | | SOLE | | 3,261,224 | 0 | 0 |
| argenx SE | SPONSORED ADR | 04016X101 | 109,186,367 | 280,159 | SH | | SOLE | | 280,159 | 0 | 0 |
| ARS Pharmaceuticals, Inc. | COM | 82835W108 | 13,443,222 | 2,006,451 | SH | | SOLE | | 2,006,451 | 0 | 0 |
| Athira Pharma, Inc. | COM | 04746L104 | 9,303,731 | 3,153,807 | SH | | SOLE | | 3,153,807 | 0 | 0 |
| Atreca, Inc. | CL A COM | 04965G109 | 3,462,105 | 3,532,760 | SH | | SOLE | | 3,532,760 | 0 | 0 |
| Avidity Biosciences, Inc. | COM | 05370A108 | 8,865,912 | 799,451 | SH | | SOLE | | 799,451 | 0 | 0 |
| BeiGene, Ltd. | SPONSORED ADR | 07725L102 | 2,080,564,335 | 11,668,897 | SH | | SOLE | | 11,668,897 | 0 | 0 |
| Bicycle Therapeutics plc | SPONSORED ADS | 088786108 | 21,534,133 | 843,814 | SH | | SOLE | | 843,814 | 0 | 0 |
| BioCryst Pharmaceuticals, Inc. | COM | 09058V103 | 89,484,159 | 12,710,818 | SH | | SOLE | | 12,710,818 | 0 | 0 |
| BioMarin Pharmaceutical Inc. | COM | 09061G101 | 330,272,297 | 3,810,248 | SH | | SOLE | | 3,810,248 | 0 | 0 |
| Biomea Fusion, Inc. | COM | 09077A106 | 46,291,431 | 2,108,949 | SH | | SOLE | | 2,108,949 | 0 | 0 |
| bluebird bio, Inc. | COM | 09609G100 | 8,224,062 | 2,499,715 | SH | | SOLE | | 2,499,715 | 0 | 0 |
| Cabaletta Bio, Inc. | COM | 12674W109 | 20,578,540 | 1,594,000 | SH | | SOLE | | 1,594,000 | 0 | 0 |
| Century Therapeutics, Inc. | COM | 15673T100 | 3,631,914 | 1,149,340 | SH | | SOLE | | 1,149,340 | 0 | 0 |
| Cerus Corporation | COM | 157085101 | 39,526,193 | 16,067,558 | SH | | SOLE | | 16,067,558 | 0 | 0 |
| Chinook Therapeutics, Inc. | COM | 16961L106 | 55,908,861 | 1,455,202 | SH | | SOLE | | 1,455,202 | 0 | 0 |
| Cogent Biosciences, Inc. | COM | 19240Q201 | 11,598,464 | 979,600 | SH | | SOLE | | 979,600 | 0 | 0 |
| Compass Therapeutics, Inc. | COM | 20454B104 | 4,953,263 | 1,557,630 | SH | | SOLE | | 1,557,630 | 0 | 0 |
| Day One Biopharmaceuticals, Inc. | COM | 23954D109 | 11,940,000 | 1,000,000 | SH | | SOLE | | 1,000,000 | 0 | 0 |
| DBV Technologies S.A. | SPONSORED ADR | 23306J101 | 27,767,102 | 14,614,264 | SH | | SOLE | | 14,614,264 | 0 | 0 |
| Denali Therapeutics Inc. | COM | 24823R105 | 42,946,552 | 1,455,322 | SH | | SOLE | | 1,455,322 | 0 | 0 |
| Design Therapeutics, Inc. | COM | 25056L103 | 3,150,000 | 500,000 | SH | | SOLE | | 500,000 | 0 | 0 |
| DICE Therapeutics, Inc. | COM | 23345J104 | 48,122,618 | 1,035,786 | SH | | SOLE | | 1,035,786 | 0 | 0 |
| Edgewise Therapeutics, Inc. | COM | 28036F105 | 3,875,000 | 500,000 | SH | | SOLE | | 500,000 | 0 | 0 |
| Entrada Therapeutics, Inc. | COM | 29384C108 | 73,668,500 | 4,865,819 | SH | | SOLE | | 4,865,819 | 0 | 0 |
| Fate Therapeutics, Inc. | COM | 31189P102 | 7,957,373 | 1,671,717 | SH | | SOLE | | 1,671,717 | 0 | 0 |
| FibroGen, Inc. | COM | 31572Q808 | 642,827 | 238,084 | SH | | SOLE | | 238,084 | 0 | 0 |
| Foghorn Therapeutics Inc. | COM | 344174107 | 316,990 | 45,027 | SH | | SOLE | | 45,027 | 0 | 0 |
| Genetron Holdings Limited | ADS | 37186H100 | 423,480 | 455,306 | SH | | SOLE | | 455,306 | 0 | 0 |
| Geron Corporation | COM | 374163103 | 9,826,529 | 3,061,224 | SH | | SOLE | | 3,061,224 | 0 | 0 |
| Gracell Biotechnologies Inc. | SPONSORED ADS | 38406L103 | 3,810,000 | 1,000,000 | SH | | SOLE | | 1,000,000 | 0 | 0 |
| Heron Therapeutics, Inc. | COM | 427746102 | 9,432,746 | 8,131,678 | SH | | SOLE | | 8,131,678 | 0 | 0 |
| HOOKIPA Pharma Inc. | COM | 43906K100 | 3,894,471 | 4,425,535 | SH | | SOLE | | 4,425,535 | 0 | 0 |
| IDEAYA Biosciences, Inc. | COM | 45166A102 | 24,959,891 | 1,062,123 | SH | | SOLE | | 1,062,123 | 0 | 0 |
| IGM Biosciences, Inc. | COM | 449585108 | 29,141,048 | 3,157,210 | SH | | SOLE | | 3,157,210 | 0 | 0 |
| Immatics N.V. | SHS | N44445109 | 65,095,017 | 5,640,816 | SH | | SOLE | | 5,640,816 | 0 | 0 |
| Immunocore Holdings plc | ADS | 45258D105 | 151,143,031 | 2,520,731 | SH | | SOLE | | 2,520,731 | 0 | 0 |
| ImmunoGen, Inc. | COM | 45253H101 | 28,684,230 | 1,520,097 | SH | | SOLE | | 1,520,097 | 0 | 0 |
| Incyte Corporation | COM | 45337C102 | 2,252,083,986 | 36,178,056 | SH | | SOLE | | 36,178,056 | 0 | 0 |
| Insmed Incorporated | COM PAR $.01 | 457669307 | 7,237,300 | 343,000 | SH | | SOLE | | 343,000 | 0 | 0 |
| Instil Bio, Inc. | COM | 45783C101 | 2,905,858 | 5,273,789 | SH | | SOLE | | 5,273,789 | 0 | 0 |
| Invitae Corporation | COM | 46185L103 | 10,035,648 | 8,881,104 | SH | | SOLE | | 8,881,104 | 0 | 0 |
| iTeos Therapeutics, Inc. | COM | 46565G104 | 1,990,581 | 150,346 | SH | | SOLE | | 150,346 | 0 | 0 |
| Kala Pharmaceuticals, Inc. | COM | 483119202 | 1,695,548 | 116,213 | SH | | SOLE | | 116,213 | 0 | 0 |
| Kiniksa Pharmaceuticals, Ltd. | COM CL A | G5269C101 | 39,558,844 | 2,809,577 | SH | | SOLE | | 2,809,577 | 0 | 0 |
| Kodiak Sciences Inc. | COM | 50015M109 | 119,442,381 | 17,310,490 | SH | | SOLE | | 17,310,490 | 0 | 0 |
| Krystal Biotech, Inc. | COM | 501147102 | 19,950,252 | 169,934 | SH | | SOLE | | 169,934 | 0 | 0 |
| Kymera Therapeutics, Inc. | COM | 501575104 | 100,589,067 | 4,375,340 | SH | | SOLE | | 4,375,340 | 0 | 0 |
| Leap Therapeutics, Inc. | COM | 52187K200 | 3,668,908 | 1,172,175 | SH | | SOLE | | 1,172,175 | 0 | 0 |
| MacroGenics, Inc. | COM | 556099109 | 4,775,298 | 892,579 | SH | | SOLE | | 892,579 | 0 | 0 |
| Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 356,921,103 | 1,545,113 | SH | | SOLE | | 1,545,113 | 0 | 0 |
| Mereo BioPharma Group PLC | SPONSORED ADS | 589492107 | 4,692,572 | 3,554,979 | SH | | SOLE | | 3,554,979 | 0 | 0 |
| Mersana Therapeutics, Inc. | COM | 59045L106 | 3,573,318 | 1,086,115 | SH | | SOLE | | 1,086,115 | 0 | 0 |
| Mirati Therapeutics, Inc. | COM | 60468T105 | 50,935,496 | 1,409,784 | SH | | SOLE | | 1,409,784 | 0 | 0 |
| Monte Rosa Therapeutics, Inc. | COM | 61225M102 | 20,714,064 | 3,023,951 | SH | | SOLE | | 3,023,951 | 0 | 0 |
| Natera, Inc. | COM | 632307104 | 4,866,000 | 100,000 | SH | | SOLE | | 100,000 | 0 | 0 |
| Neoleukin Therapeutics, Inc. | COM | 64049K104 | 3,172,044 | 3,821,740 | SH | | SOLE | | 3,821,740 | 0 | 0 |
| Nkarta, Inc. | COM | 65487U108 | 594,211 | 271,329 | SH | | SOLE | | 271,329 | 0 | 0 |
| Nurix Therapeutics, Inc. | COM | 67080M103 | 38,782,429 | 3,882,125 | SH | | SOLE | | 3,882,125 | 0 | 0 |
| Opthea Limited | SPONSORED ADS | 68386J208 | 7,535,895 | 2,691,391 | SH | | SOLE | | 2,691,391 | 0 | 0 |
| Pacific Biosciences of California, Inc. | COM | 69404D108 | 14,999,501 | 1,127,782 | SH | | SOLE | | 1,127,782 | 0 | 0 |
| Perspective Therapeutics, Inc. | COM | 46489V104 | 1,549,283 | 2,319,286 | SH | | SOLE | | 2,319,286 | 0 | 0 |
| PMV Pharmaceuticals, Inc. | COM | 69353Y103 | 2,015,870 | 322,024 | SH | | SOLE | | 322,024 | 0 | 0 |
| POINT Biopharma Global Inc. | COM | 730541109 | 10,592,073 | 1,169,103 | SH | | SOLE | | 1,169,103 | 0 | 0 |
| Praxis Precision Medicines, Inc. | COM | 74006W108 | 2,161,902 | 1,879,915 | SH | | SOLE | | 1,879,915 | 0 | 0 |
| Prelude Therapeutics Inc. | COM | 74065P101 | 45,557,208 | 10,123,824 | SH | | SOLE | | 10,123,824 | 0 | 0 |
| Prime Medicine, Inc. | COM | 74168J101 | 15,067,027 | 1,028,466 | SH | | SOLE | | 1,028,466 | 0 | 0 |
| Protara Therapeutics, Inc. | COM STK | 74365U107 | 477,214 | 199,671 | SH | | SOLE | | 199,671 | 0 | 0 |
| Relay Therapeutics, Inc. | COM | 75943R102 | 14,571,070 | 1,160,117 | SH | | SOLE | | 1,160,117 | 0 | 0 |
| Replimune Group, Inc. | COM | 76029N106 | 106,307,662 | 4,578,280 | SH | | SOLE | | 4,578,280 | 0 | 0 |
| Revolution Medicines, Inc. | COM | 76155X100 | 71,997,438 | 2,691,493 | SH | | SOLE | | 2,691,493 | 0 | 0 |
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | 107,156,423 | 6,498,267 | SH | | SOLE | | 6,498,267 | 0 | 0 |
| Roivant Sciences Ltd. | SHS | G76279101 | 95,040,207 | 9,428,592 | SH | | SOLE | | 9,428,592 | 0 | 0 |
| Sana Biotechnology, Inc. | COM | 799566104 | 11,920,000 | 2,000,000 | SH | | SOLE | | 2,000,000 | 0 | 0 |
| Seagen Inc. | COM | 81181C104 | 8,574,894,019 | 44,554,162 | SH | | SOLE | | 44,554,162 | 0 | 0 |
| Sera Prognostics, Inc. | CLASS A COM | 81749D107 | 5,856,648 | 1,777,435 | SH | | SOLE | | 1,777,435 | 0 | 0 |
| SpringWorks Therapeutics, Inc. | COM | 85205L107 | 78,655,962 | 2,999,846 | SH | | SOLE | | 2,999,846 | 0 | 0 |
| Stoke Therapeutics, Inc. | COM | 86150R107 | 22,644,430 | 2,130,238 | SH | | SOLE | | 2,130,238 | 0 | 0 |
| Summit Therapeutics Inc. | COM | 86627T108 | 15,824,810 | 6,304,705 | SH | | SOLE | | 6,304,705 | 0 | 0 |
| Surrozen, Inc. | W EXP 8/11/2026 | 86889P117 | 46,000 | 833,333 | SH | | SOLE | | 833,333 | 0 | 0 |
| Talis Biomedical Corporation | COM | 87424L207 | 3,659,921 | 7,624,835 | SH | | SOLE | | 7,624,835 | 0 | 0 |
| Tango Therapeutics, Inc. | COM | 87583X109 | 2,490,000 | 750,000 | SH | | SOLE | | 750,000 | 0 | 0 |
| TScan Therapeutics, Inc. | COM | 89854M101 | 6,961,980 | 2,784,792 | SH | | SOLE | | 2,784,792 | 0 | 0 |
| Ultragenyx Pharmaceutical Inc. | COM | 90400D108 | 36,122,512 | 783,059 | SH | | SOLE | | 783,059 | 0 | 0 |
| Vaxcyte, Inc. | COM | 92243G108 | 2,441,317 | 48,885 | SH | | SOLE | | 48,885 | 0 | 0 |
| Vera Therapeutics, Inc. | CL A | 92337R101 | 2,350,747 | 146,464 | SH | | SOLE | | 146,464 | 0 | 0 |
| Verastem, Inc. | COM | 92337C203 | 9,943,448 | 1,336,485 | SH | | SOLE | | 1,336,485 | 0 | 0 |
| Verve Therapeutics, Inc. | COM | 92539P101 | 26,559,938 | 1,416,530 | SH | | SOLE | | 1,416,530 | 0 | 0 |
| Vincerx Pharma, Inc. | COM | 92731L106 | 293,253 | 225,579 | SH | | SOLE | | 225,579 | 0 | 0 |
| Vor Biopharma Inc. | COM | 929033108 | 1,958,590 | 633,848 | SH | | SOLE | | 633,848 | 0 | 0 |
| Xencor, Inc. | COM | 98401F105 | 3,074,481 | 123,127 | SH | | SOLE | | 123,127 | 0 | 0 |
| Xenon Pharmaceuticals Inc. | COM | 98420N105 | 28,938,102 | 751,639 | SH | | SOLE | | 751,639 | 0 | 0 |
| Invitae Corporation | Note 1.5% 4/1/2028 | 46185LAD5 | 135,000,000 | 300,000,000 | PRN | | SOLE | | 300,000,000 | 0 | 0 |
