| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 2seventy bio, Inc. | COM | 901384107 | 10,664,436 | 2,497,526 | SH | | SOLE | | 2,497,526 | 0 | 0 |
| Aadi Bioscience, Inc. | COM | 00032Q104 | 508,489 | 251,727 | SH | | SOLE | | 251,727 | 0 | 0 |
| AbCellera Biologics Inc. | COM | 00288U106 | 130,814,690 | 22,909,753 | SH | | SOLE | | 22,909,753 | 0 | 0 |
| ACADIA Pharmaceuticals Inc. | COM | 004225108 | 1,342,091,002 | 42,864,612 | SH | | SOLE | | 42,864,612 | 0 | 0 |
| Achilles Therapeutics plc | SPONSORED ADS | 00449L102 | 1,869,382 | 2,102,792 | SH | | SOLE | | 2,102,792 | 0 | 0 |
| Adaptimmune Therapeutics plc | SPONSORED ADR | 00653A107 | 8,698,641 | 10,969,282 | SH | | SOLE | | 10,969,282 | 0 | 0 |
| Aerovate Therapeutics, Inc. | COM | 008064107 | 38,030,100 | 1,680,517 | SH | | SOLE | | 1,680,517 | 0 | 0 |
| Akero Therapeutics, Inc. | COM | 00973Y108 | 55,301,626 | 2,368,378 | SH | | SOLE | | 2,368,378 | 0 | 0 |
| Aligos Therapeutics, Inc. | COM | 01626L105 | 1,378,730 | 2,076,400 | SH | | SOLE | | 2,076,400 | 0 | 0 |
| argenx SE | SPONSORED ADR | 04016X101 | 57,526,722 | 151,215 | SH | | SOLE | | 151,215 | 0 | 0 |
| ARS Pharmaceuticals, Inc. | COM | 82835W108 | 10,995,351 | 2,006,451 | SH | | SOLE | | 2,006,451 | 0 | 0 |
| Athira Pharma, Inc. | COM | 04746L104 | 7,663,751 | 3,153,807 | SH | | SOLE | | 3,153,807 | 0 | 0 |
| Atreca, Inc. | CL A COM | 04965G109 | 287,430 | 2,177,499 | SH | | SOLE | | 2,177,499 | 0 | 0 |
| BeiGene, Ltd. | SPONSORED ADR | 07725L102 | 1,906,206,263 | 10,568,897 | SH | | SOLE | | 10,568,897 | 0 | 0 |
| Bicycle Therapeutics plc | SPONSORED ADS | 088786108 | 32,370,251 | 1,790,390 | SH | | SOLE | | 1,790,390 | 0 | 0 |
| BioCryst Pharmaceuticals, Inc. | COM | 09058V103 | 60,655,794 | 10,126,176 | SH | | SOLE | | 10,126,176 | 0 | 0 |
| Biomea Fusion, Inc. | COM | 09077A106 | 30,621,939 | 2,108,949 | SH | | SOLE | | 2,108,949 | 0 | 0 |
| Cabaletta Bio, Inc. | COM | 12674W109 | 302,614 | 13,331 | SH | | SOLE | | 13,331 | 0 | 0 |
| Celcuity Inc. | COM | 15102K100 | 7,801,914 | 535,478 | SH | | SOLE | | 535,478 | 0 | 0 |
| Celldex Therapeutics, Inc. | COM | 15117B202 | 9,821,561 | 247,644 | SH | | SOLE | | 247,644 | 0 | 0 |
| Century Therapeutics, Inc. | COM | 15673T100 | 2,647,567 | 797,460 | SH | | SOLE | | 797,460 | 0 | 0 |
| Cerevel Therapeutics Holdings, Inc. | COM | 15678U128 | 67,840,000 | 1,600,000 | SH | | SOLE | | 1,600,000 | 0 | 0 |
| Cerus Corporation | COM | 157085101 | 42,071,052 | 19,477,339 | SH | | SOLE | | 19,477,339 | 0 | 0 |
| Compass Therapeutics, Inc. | COM | 20454B104 | 2,429,903 | 1,557,630 | SH | | SOLE | | 1,557,630 | 0 | 0 |
| Day One Biopharmaceuticals, Inc. | COM | 23954D109 | 14,600,000 | 1,000,000 | SH | | SOLE | | 1,000,000 | 0 | 0 |
| DBV Technologies S.A. | SPONSORED ADR | 23306J101 | 13,924,471 | 14,614,264 | SH | | SOLE | | 14,614,264 | 0 | 0 |
| Denali Therapeutics Inc. | COM | 24823R105 | 55,950,426 | 2,607,196 | SH | | SOLE | | 2,607,196 | 0 | 0 |
| Design Therapeutics, Inc. | COM | 25056L103 | 3,975,000 | 1,500,000 | SH | | SOLE | | 1,500,000 | 0 | 0 |
| Edgewise Therapeutics, Inc. | COM | 28036F105 | 34,053,879 | 3,112,786 | SH | | SOLE | | 3,112,786 | 0 | 0 |
| Entrada Therapeutics, Inc. | COM | 29384C108 | 73,425,209 | 4,865,819 | SH | | SOLE | | 4,865,819 | 0 | 0 |
| Foghorn Therapeutics Inc. | COM | 344174107 | 290,424 | 45,027 | SH | | SOLE | | 45,027 | 0 | 0 |
| Gracell Biotechnologies Inc. | SPONSORED ADS | 38406L103 | 20,883,200 | 2,080,000 | SH | | SOLE | | 2,080,000 | 0 | 0 |
| HOOKIPA Pharma Inc. | COM | 43906K100 | 6,583,802 | 8,128,151 | SH | | SOLE | | 8,128,151 | 0 | 0 |
| IDEAYA Biosciences, Inc. | COM | 45166A102 | 37,790,336 | 1,062,123 | SH | | SOLE | | 1,062,123 | 0 | 0 |
| IGM Biosciences, Inc. | COM | 449585108 | 30,672,301 | 3,691,011 | SH | | SOLE | | 3,691,011 | 0 | 0 |
| Immatics N.V. | SHS | N44445109 | 61,483,122 | 5,838,853 | SH | | SOLE | | 5,838,853 | 0 | 0 |
| Immunocore Holdings plc | ADS | 45258D105 | 172,216,342 | 2,520,731 | SH | | SOLE | | 2,520,731 | 0 | 0 |
| Immunovant, Inc. | COM | 45258J102 | 17,905,629 | 425,009 | SH | | SOLE | | 425,009 | 0 | 0 |
| Incyte Corporation | COM | 45337C102 | 2,271,687,070 | 36,179,122 | SH | | SOLE | | 36,179,122 | 0 | 0 |
| Insmed Incorporated | COM PAR $.01 | 457669307 | 10,629,570 | 343,000 | SH | | SOLE | | 343,000 | 0 | 0 |
| Invitae Corporation | COM | 46185L103 | 1,106,017 | 1,764,546 | SH | | SOLE | | 1,764,546 | 0 | 0 |
| KALA BIO, Inc. | COM | 483119202 | 1,866,291 | 266,613 | SH | | SOLE | | 266,613 | 0 | 0 |
| Kiniksa Pharmaceuticals, Ltd. | COM CL A | G5269C101 | 49,279,981 | 2,809,577 | SH | | SOLE | | 2,809,577 | 0 | 0 |
| Kodiak Sciences Inc. | COM | 50015M109 | 52,623,890 | 17,310,490 | SH | | SOLE | | 17,310,490 | 0 | 0 |
| Krystal Biotech, Inc. | COM | 501147102 | 21,082,012 | 169,934 | SH | | SOLE | | 169,934 | 0 | 0 |
| Kymera Therapeutics, Inc. | COM | 501575104 | 152,656,327 | 5,995,928 | SH | | SOLE | | 5,995,928 | 0 | 0 |
| Leap Therapeutics, Inc. | COM | 52187K200 | 4,858,665 | 1,172,175 | SH | | SOLE | | 1,172,175 | 0 | 0 |
| Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 455,771,861 | 1,969,798 | SH | | SOLE | | 1,969,798 | 0 | 0 |
| Mersana Therapeutics, Inc. | COM | 59045L106 | 2,519,787 | 1,086,115 | SH | | SOLE | | 1,086,115 | 0 | 0 |
| Mirati Therapeutics, Inc. | COM | 60468T105 | 242,134,600 | 4,121,440 | SH | | SOLE | | 4,121,440 | 0 | 0 |
| Mirum Pharmaceuticals, Inc. | COM | 604749101 | 5,622,852 | 190,476 | SH | | SOLE | | 190,476 | 0 | 0 |
| Monte Rosa Therapeutics, Inc. | COM | 61225M102 | 27,775,937 | 4,916,095 | SH | | SOLE | | 4,916,095 | 0 | 0 |
| Neurogene Inc. | COM | 64135M105 | 8,789,140 | 453,516 | SH | | SOLE | | 453,516 | 0 | 0 |
| Nurix Therapeutics, Inc. | COM | 67080M103 | 40,063,530 | 3,882,125 | SH | | SOLE | | 3,882,125 | 0 | 0 |
| Opthea Limited | SPONSORED ADS | 68386J208 | 7,636,503 | 2,588,645 | SH | | SOLE | | 2,588,645 | 0 | 0 |
| Perspective Therapeutics, Inc. | COM | 46489V104 | 3,071,161 | 7,639,703 | SH | | SOLE | | 7,639,703 | 0 | 0 |
| Pfizer Inc. | COM | 717081103 | 1,007,650 | 35,000 | SH | | SOLE | | 35,000 | 0 | 0 |
| PMV Pharmaceuticals, Inc. | COM | 69353Y103 | 998,274 | 322,024 | SH | | SOLE | | 322,024 | 0 | 0 |
| Praxis Precision Medicines, Inc. | COM | 74006W108 | 2,930,555 | 131,533 | SH | | SOLE | | 131,533 | 0 | 0 |
| Prelude Therapeutics Inc. | COM | 74065P101 | 43,228,728 | 10,123,824 | SH | | SOLE | | 10,123,824 | 0 | 0 |
| Prime Medicine, Inc. | COM | 74168J101 | 9,112,209 | 1,028,466 | SH | | SOLE | | 1,028,466 | 0 | 0 |
| Protara Therapeutics, Inc. | COM STK | 74365U107 | 374,403 | 199,671 | SH | | SOLE | | 199,671 | 0 | 0 |
| Relay Therapeutics, Inc. | COM | 75943R102 | 12,772,888 | 1,160,117 | SH | | SOLE | | 1,160,117 | 0 | 0 |
| Replimune Group, Inc. | COM | 76029N106 | 80,467,182 | 9,545,336 | SH | | SOLE | | 9,545,336 | 0 | 0 |
| Revolution Medicines, Inc. | COM | 76155X100 | 147,663,483 | 5,148,657 | SH | | SOLE | | 5,148,657 | 0 | 0 |
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | 294,132,839 | 6,398,365 | SH | | SOLE | | 6,398,365 | 0 | 0 |
| Roivant Sciences Ltd. | SHS | G76279101 | 85,269,660 | 7,593,024 | SH | | SOLE | | 7,593,024 | 0 | 0 |
| Sagimet Biosciences Inc. | COM SER A | 786700104 | 7,894,328 | 1,456,518 | SH | | SOLE | | 1,456,518 | 0 | 0 |
| Sana Biotechnology, Inc. | COM | 799566104 | 8,160,000 | 2,000,000 | SH | | SOLE | | 2,000,000 | 0 | 0 |
| Sera Prognostics, Inc. | CLASS A COM | 81749D107 | 32,497,706 | 5,434,399 | SH | | SOLE | | 5,434,399 | 0 | 0 |
| Stoke Therapeutics, Inc. | COM | 86150R107 | 10,678,505 | 2,030,134 | SH | | SOLE | | 2,030,134 | 0 | 0 |
| Surrozen, Inc. | W EXP 8/11/2026 | 86889P117 | 16,167 | 833,333 | SH | | SOLE | | 833,333 | 0 | 0 |
| Talis Biomedical Corporation | COM | 87424L207 | 3,787,006 | 508,323 | SH | | SOLE | | 508,323 | 0 | 0 |
| Tango Therapeutics, Inc. | COM | 87583X109 | 7,425,000 | 750,000 | SH | | SOLE | | 750,000 | 0 | 0 |
| Taysha Gene Therapies, Inc. | COM SHS | 877619106 | 7,088,418 | 4,004,756 | SH | | SOLE | | 4,004,756 | 0 | 0 |
| TScan Therapeutics, Inc. | COM | 89854M101 | 16,235,337 | 2,784,792 | SH | | SOLE | | 2,784,792 | 0 | 0 |
| Tyra Biosciences, Inc. | COM | 90240B106 | 146,907 | 10,607 | SH | | SOLE | | 10,607 | 0 | 0 |
| Ultragenyx Pharmaceutical Inc. | COM | 90400D108 | 70,130,278 | 1,466,547 | SH | | SOLE | | 1,466,547 | 0 | 0 |
| Vaxcyte, Inc. | COM | 92243G108 | 3,069,978 | 48,885 | SH | | SOLE | | 48,885 | 0 | 0 |
| Verve Therapeutics, Inc. | COM | 92539P101 | 23,579,928 | 1,691,530 | SH | | SOLE | | 1,691,530 | 0 | 0 |
| Xencor, Inc. | COM | 98401F105 | 5,210,500 | 245,431 | SH | | SOLE | | 245,431 | 0 | 0 |
| Xenon Pharmaceuticals Inc. | COM | 98420N105 | 45,768,855 | 993,679 | SH | | SOLE | | 993,679 | 0 | 0 |
| Invitae Corporation | Notes 1.5% 4/1/2028 | 46185LAD5 | 131,152,500 | 300,000,000 | PRN | | SOLE | | 300,000,000 | 0 | 0 |
| Invitae Corporation | Series A Notes 4.5% 3/15/2028 | 46185LAH6 | 6,272,702 | 9,274,000 | PRN | | SOLE | | 9,274,000 | 0 | 0 |
