| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 2seventy bio, Inc. | COMMON STOCK | 901384107 | 9,615,475 | 2,497,526 | SH | | SOLE | | 2,497,526 | 0 | 0 |
| AbCellera Biologics Inc. | COM | 00288U106 | 81,475,894 | 27,525,640 | SH | | SOLE | | 27,525,640 | 0 | 0 |
| ACADIA Pharmaceuticals Inc. | COM | 004225108 | 696,766,135 | 42,877,916 | SH | | SOLE | | 42,877,916 | 0 | 0 |
| Achilles Therapeutics plc | SPONSORED ADS | 00449L102 | 903,645 | 1,108,767 | SH | | SOLE | | 1,108,767 | 0 | 0 |
| Acrivon Therapeutics, Inc. | COMMON STOCK | 004890109 | 306,733 | 52,885 | SH | | SOLE | | 52,885 | 0 | 0 |
| Adaptimmune Therapeutics plc | SPONSORED ADR | 00653A107 | 2,284,868 | 2,343,695 | SH | | SOLE | | 2,343,695 | 0 | 0 |
| Aerovate Therapeutics, Inc. | COM | 008064107 | 1,044,039 | 628,939 | SH | | SOLE | | 628,939 | 0 | 0 |
| Akero Therapeutics, Inc. | COM | 00973Y108 | 25,737,544 | 1,097,082 | SH | | SOLE | | 1,097,082 | 0 | 0 |
| Alector, Inc. | COM | 014442107 | 4,209,779 | 927,264 | SH | | SOLE | | 927,264 | 0 | 0 |
| Aligos Therapeutics, Inc. | COM | 01626L105 | 726,740 | 2,076,400 | SH | | SOLE | | 2,076,400 | 0 | 0 |
| Alkermes plc | SHS | G01767105 | 100,780,199 | 4,181,751 | SH | | SOLE | | 4,181,751 | 0 | 0 |
| Alumis Inc. | COM | 022307102 | 20,781,250 | 1,562,500 | SH | | SOLE | | 1,562,500 | 0 | 0 |
| Arcturus Therapeutics Holdings Inc. | COM | 03969T109 | 3,684,861 | 151,329 | SH | | SOLE | | 151,329 | 0 | 0 |
| argenx SE | SPONSORED ADR | 04016X101 | 48,123,196 | 111,904 | SH | | SOLE | | 111,904 | 0 | 0 |
| Athira Pharma, Inc. | COM | 04746L104 | 8,357,589 | 3,153,807 | SH | | SOLE | | 3,153,807 | 0 | 0 |
| BeiGene, Ltd. | SPONSORED ADR | 07725L102 | 1,507,864,535 | 10,568,897 | SH | | SOLE | | 10,568,897 | 0 | 0 |
| Bicycle Therapeutics plc | SPONSORED ADS | 088786108 | 190,255,190 | 9,399,960 | SH | | SOLE | | 9,399,960 | 0 | 0 |
| BioCryst Pharmaceuticals, Inc. | COM | 09058V103 | 468,308 | 75,778 | SH | | SOLE | | 75,778 | 0 | 0 |
| Biomea Fusion, Inc. | COM | 09077A106 | 9,490,271 | 2,108,949 | SH | | SOLE | | 2,108,949 | 0 | 0 |
| Celcuity Inc. | COM | 15102K100 | 30,712,140 | 1,874,978 | SH | | SOLE | | 1,874,978 | 0 | 0 |
| Celldex Therapeutics, Inc. | COM | 15117B202 | 9,165,304 | 247,644 | SH | | SOLE | | 247,644 | 0 | 0 |
| Centessa Pharmaceuticals plc | SPONSORED ADS | 152309100 | 4,959,384 | 549,212 | SH | | SOLE | | 549,212 | 0 | 0 |
| Century Therapeutics, Inc. | COM | 15673T100 | 2,033,523 | 797,460 | SH | | SOLE | | 797,460 | 0 | 0 |
| Cerevel Therapeutics Holdings, Inc. | COM | 15678U128 | 27,951,913 | 683,588 | SH | | SOLE | | 683,588 | 0 | 0 |
| Cerus Corporation | COM | 157085101 | 34,280,117 | 19,477,339 | SH | | SOLE | | 19,477,339 | 0 | 0 |
| Compass Therapeutics, Inc. | COM | 20454B104 | 1,557,630 | 1,557,630 | SH | | SOLE | | 1,557,630 | 0 | 0 |
| Contineum Therapeutics, Inc. | CL A | 21217B100 | 5,503,125 | 312,500 | SH | | SOLE | | 312,500 | 0 | 0 |
| Crinetics Pharmaceuticals, Inc. | COM | 22663K107 | 4,654,890 | 103,927 | SH | | SOLE | | 103,927 | 0 | 0 |
| CRISPR Therapeutics AG | NAMEN AKT | H17182108 | 5,401,000 | 100,000 | SH | | SOLE | | 100,000 | 0 | 0 |
| DBV Technologies S.A. | SPONSORED ADR | 23306J200 | 5,853,012 | 7,307,131 | SH | | SOLE | | 7,307,131 | 0 | 0 |
| Denali Therapeutics Inc. | COM | 24823R105 | 86,649,958 | 3,731,695 | SH | | SOLE | | 3,731,695 | 0 | 0 |
| Design Therapeutics, Inc. | COM | 25056L103 | 5,679,235 | 1,695,294 | SH | | SOLE | | 1,695,294 | 0 | 0 |
| Dyne Therapeutics, Inc. | COM | 26818M108 | 23,718,268 | 672,096 | SH | | SOLE | | 672,096 | 0 | 0 |
| Edgewise Therapeutics, Inc. | COM | 28036F105 | 105,179,463 | 5,840,059 | SH | | SOLE | | 5,840,059 | 0 | 0 |
| Enliven Therapeutics, Inc. | COM | 29337E102 | 2,683,647 | 114,833 | SH | | SOLE | | 114,833 | 0 | 0 |
| Entrada Therapeutics, Inc. | COM | 29384C108 | 69,337,921 | 4,865,819 | SH | | SOLE | | 4,865,819 | 0 | 0 |
| Fate Therapeutics, Inc. | COM | 31189P102 | 9,832,692 | 2,997,772 | SH | | SOLE | | 2,997,772 | 0 | 0 |
| Foghorn Therapeutics Inc. | COM | 344174107 | 258,905 | 45,027 | SH | | SOLE | | 45,027 | 0 | 0 |
| Generation Bio Co. | COM | 37148K100 | 3,403,619 | 1,206,957 | SH | | SOLE | | 1,206,957 | 0 | 0 |
| HOOKIPA Pharma Inc. | COM | 43906K209 | 4,810,240 | 8,128,151 | SH | | SOLE | | 8,128,151 | 0 | 0 |
| IDEAYA Biosciences, Inc. | COM | 45166A102 | 37,291,139 | 1,062,123 | SH | | SOLE | | 1,062,123 | 0 | 0 |
| IGM Biosciences, Inc. | COM | 449585108 | 28,100,471 | 4,090,316 | SH | | SOLE | | 4,090,316 | 0 | 0 |
| Immatics N.V. | SHS | N44445109 | 74,872,285 | 6,443,398 | SH | | SOLE | | 6,443,398 | 0 | 0 |
| Immunocore Holdings plc | ADS | 45258D105 | 51,354,127 | 1,515,318 | SH | | SOLE | | 1,515,318 | 0 | 0 |
| Immunovant, Inc. | COM | 45258J102 | 12,268,555 | 464,718 | SH | | SOLE | | 464,718 | 0 | 0 |
| Incyte Corporation | COM | 45337C102 | 1,863,369,325 | 30,738,524 | SH | | SOLE | | 30,738,524 | 0 | 0 |
| Insmed Incorporated | COM PAR $.01 | 457669307 | 239,594,546 | 3,576,038 | SH | | SOLE | | 3,576,038 | 0 | 0 |
| KALA BIO, Inc. | COM | 483119202 | 6,319,565 | 891,335 | SH | | SOLE | | 891,335 | 0 | 0 |
| Kiniksa Pharmaceuticals International, plc | ORD SHS CL A | G52694109 | 52,618,090 | 2,818,323 | SH | | SOLE | | 2,818,323 | 0 | 0 |
| Kodiak Sciences Inc. | COM | 50015M109 | 40,679,652 | 17,310,490 | SH | | SOLE | | 17,310,490 | 0 | 0 |
| Krystal Biotech, Inc. | COM | 501147102 | 31,206,680 | 169,934 | SH | | SOLE | | 169,934 | 0 | 0 |
| Kymera Therapeutics, Inc. | COM | 501575104 | 178,978,451 | 5,995,928 | SH | | SOLE | | 5,995,928 | 0 | 0 |
| Leap Therapeutics, Inc. | COM | 52187K200 | 2,297,463 | 1,172,175 | SH | | SOLE | | 1,172,175 | 0 | 0 |
| Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 553,201,134 | 1,974,590 | SH | | SOLE | | 1,974,590 | 0 | 0 |
| Mersana Therapeutics, Inc. | COM | 59045L106 | 2,183,091 | 1,086,115 | SH | | SOLE | | 1,086,115 | 0 | 0 |
| Merus N.V. | COM | N5749R100 | 17,751,000 | 300,000 | SH | | SOLE | | 300,000 | 0 | 0 |
| Mirum Pharmaceuticals, Inc. | COM | 604749101 | 6,512,374 | 190,476 | SH | | SOLE | | 190,476 | 0 | 0 |
| Monte Rosa Therapeutics, Inc. | COM | 61225M102 | 18,386,195 | 4,916,095 | SH | | SOLE | | 4,916,095 | 0 | 0 |
| Neumora Therapeutics, Inc. | COM | 640979100 | 10,170,118 | 1,034,600 | SH | | SOLE | | 1,034,600 | 0 | 0 |
| Neurogene Inc. | COM | 64135M105 | 16,594,386 | 456,015 | SH | | SOLE | | 456,015 | 0 | 0 |
| NewAmsterdam Pharma Company N.V. | ORDINARY SHARES | N62509109 | 1,860,047 | 96,827 | SH | | SOLE | | 96,827 | 0 | 0 |
| Nurix Therapeutics, Inc. | COM | 67080M103 | 81,019,949 | 3,882,125 | SH | | SOLE | | 3,882,125 | 0 | 0 |
| Opthea Limited | SPONSORED ADS | 68386J208 | 4,195,090 | 2,173,622 | SH | | SOLE | | 2,173,622 | 0 | 0 |
| Pfizer Inc. | COM | 717081103 | 979,300 | 35,000 | SH | | SOLE | | 35,000 | 0 | 0 |
| PMV Pharmaceuticals, Inc. | COM | 69353Y103 | 521,679 | 322,024 | SH | | SOLE | | 322,024 | 0 | 0 |
| Praxis Precision Medicines, Inc. | COM | 74006W207 | 5,440,205 | 131,533 | SH | | SOLE | | 131,533 | 0 | 0 |
| Prelude Therapeutics Inc. | COM | 74065P101 | 38,571,769 | 10,123,824 | SH | | SOLE | | 10,123,824 | 0 | 0 |
| Prime Medicine, Inc. | COM | 74168J101 | 5,286,315 | 1,028,466 | SH | | SOLE | | 1,028,466 | 0 | 0 |
| Protara Therapeutics, Inc. | COM STK | 74365U107 | 1,116,611 | 536,832 | SH | | SOLE | | 536,832 | 0 | 0 |
| Relay Therapeutics, Inc. | COM | 75943R102 | 7,563,963 | 1,160,117 | SH | | SOLE | | 1,160,117 | 0 | 0 |
| Replimune Group, Inc. | COM | 76029N106 | 90,408,024 | 10,045,336 | SH | | SOLE | | 10,045,336 | 0 | 0 |
| Revolution Medicines, Inc. | COM | 76155X100 | 293,756,383 | 7,569,090 | SH | | SOLE | | 7,569,090 | 0 | 0 |
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | 262,716,867 | 6,398,365 | SH | | SOLE | | 6,398,365 | 0 | 0 |
| Roivant Sciences Ltd. | SHS | G76279101 | 29,582,428 | 2,798,716 | SH | | SOLE | | 2,798,716 | 0 | 0 |
| Sage Therapeutics, Inc. | COM | 78667J108 | 1,857,342 | 171,026 | SH | | SOLE | | 171,026 | 0 | 0 |
| Sagimet Biosciences Inc. | COM SER A | 786700104 | 4,726,091 | 1,381,898 | SH | | SOLE | | 1,381,898 | 0 | 0 |
| Sana Biotechnology, Inc. | COM | 799566104 | 12,999,982 | 2,380,949 | SH | | SOLE | | 2,380,949 | 0 | 0 |
| Sera Prognostics, Inc. | CLASS A COM | 81749D107 | 32,171,642 | 5,434,399 | SH | | SOLE | | 5,434,399 | 0 | 0 |
| Skye Bioscience, Inc. | COM | 83086J200 | 4,005,000 | 500,000 | SH | | SOLE | | 500,000 | 0 | 0 |
| Stoke Therapeutics, Inc. | COM | 86150R107 | 59,017,665 | 4,368,443 | SH | | SOLE | | 4,368,443 | 0 | 0 |
| Summit Therapeutics Inc. | COM | 86627T108 | 181,133,332 | 23,222,222 | SH | | SOLE | | 23,222,222 | 0 | 0 |
| Surrozen, Inc. | W EXP 8/11/2026 | 86889P117 | 13,833 | 833,333 | SH | | SOLE | | 833,333 | 0 | 0 |
| Talis Biomedical Corporation | COM | 87424L207 | 4,402,992 | 508,323 | SH | | SOLE | | 508,323 | 0 | 0 |
| Tango Therapeutics, Inc. | COM | 87583X109 | 6,435,000 | 750,000 | SH | | SOLE | | 750,000 | 0 | 0 |
| Taysha Gene Therapies, Inc. | COM SHS | 877619106 | 8,970,653 | 4,004,756 | SH | | SOLE | | 4,004,756 | 0 | 0 |
| TScan Therapeutics, Inc. | COM | 89854M101 | 16,291,033 | 2,784,792 | SH | | SOLE | | 2,784,792 | 0 | 0 |
| Tyra Biosciences, Inc. | COM | 90240B106 | 169,606 | 10,607 | SH | | SOLE | | 10,607 | 0 | 0 |
| Ultragenyx Pharmaceutical Inc. | COM | 90400D108 | 60,275,082 | 1,466,547 | SH | | SOLE | | 1,466,547 | 0 | 0 |
| Vaxcyte, Inc. | COM | 92243G108 | 3,691,306 | 48,885 | SH | | SOLE | | 48,885 | 0 | 0 |
| Verve Therapeutics, Inc. | COM | 92539P101 | 8,254,666 | 1,691,530 | SH | | SOLE | | 1,691,530 | 0 | 0 |
| vTv Therapeutics, Inc. | CL A | 918385204 | 1,718,565 | 97,314 | SH | | SOLE | | 97,314 | 0 | 0 |
| Xencor, Inc. | COM | 98401F105 | 10,325,009 | 545,431 | SH | | SOLE | | 545,431 | 0 | 0 |
| Xenon Pharmaceuticals Inc. | COM | 98420N105 | 38,743,544 | 993,679 | SH | | SOLE | | 993,679 | 0 | 0 |
| Insmed Incorporated | Note 0.75% 6/1/2028 | 457669AB5 | 90,413,500 | 42,850,000 | PRN | | SOLE | | 42,850,000 | 0 | 0 |
| Insmed Incorporated | Note 1.75% 1/15/2025 | 457669AA7 | 56,192,307 | 32,887,000 | PRN | | SOLE | | 32,887,000 | 0 | 0 |
