The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
| ||||||||||||||||||||
| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 2seventy bio, Inc. | COMMON STOCK | 901384107 | 11,788,323 | 2,497,526 | SH | SOLE | 2,497,526 | 0 | 0 | ||
| AbCellera Biologics Inc. | COM | 00288U106 | 71,566,664 | 27,525,640 | SH | SOLE | 27,525,640 | 0 | 0 | ||
| ACADIA Pharmaceuticals Inc. | COM | 004225108 | 659,462,348 | 42,877,916 | SH | SOLE | 42,877,916 | 0 | 0 | ||
| Acrivon Therapeutics, Inc. | COMMON STOCK | 004890109 | 370,195 | 52,885 | SH | SOLE | 52,885 | 0 | 0 | ||
| Aerovate Therapeutics, Inc. | COM | 008064107 | 1,314,483 | 628,939 | SH | SOLE | 628,939 | 0 | 0 | ||
| Akero Therapeutics, Inc. | COM | 00973Y108 | 31,475,283 | 1,097,082 | SH | SOLE | 1,097,082 | 0 | 0 | ||
| Alector, Inc. | COM | 014442107 | 4,321,050 | 927,264 | SH | SOLE | 927,264 | 0 | 0 | ||
| Aligos Therapeutics, Inc. | COM | 01626L204 | 719,256 | 83,055 | SH | SOLE | 83,055 | 0 | 0 | ||
| Alkermes plc | SHS | G01767105 | 117,047,210 | 4,181,751 | SH | SOLE | 4,181,751 | 0 | 0 | ||
| Alumis Inc. | COM | 022307102 | 16,687,500 | 1,562,500 | SH | SOLE | 1,562,500 | 0 | 0 | ||
| Arcturus Therapeutics Holdings Inc. | COM | 03969T109 | 3,512,346 | 151,329 | SH | SOLE | 151,329 | 0 | 0 | ||
| argenx SE | SPONSORED ADR | 04016X101 | 60,660,920 | 111,904 | SH | SOLE | 111,904 | 0 | 0 | ||
| Arvinas, Inc. | COM | 04335A105 | 9,989,337 | 405,576 | SH | SOLE | 405,576 | 0 | 0 | ||
| BeiGene, Ltd. | SPONSORED ADR | 07725L102 | 2,372,823,065 | 10,568,897 | SH | SOLE | 10,568,897 | 0 | 0 | ||
| Bicara Therapeutics Inc. | COM | 055477103 | 21,224,992 | 833,333 | SH | SOLE | 833,333 | 0 | 0 | ||
| Bicycle Therapeutics plc | SPONSORED ADS | 088786108 | 212,721,095 | 9,399,960 | SH | SOLE | 9,399,960 | 0 | 0 | ||
| BioCryst Pharmaceuticals, Inc. | COM | 09058V103 | 575,913 | 75,778 | SH | SOLE | 75,778 | 0 | 0 | ||
| Biomea Fusion, Inc. | COM | 09077A106 | 21,300,385 | 2,108,949 | SH | SOLE | 2,108,949 | 0 | 0 | ||
| Celcuity Inc. | COM | 15102K100 | 27,955,922 | 1,874,978 | SH | SOLE | 1,874,978 | 0 | 0 | ||
| Celldex Therapeutics, Inc. | COM | 15117B202 | 8,417,420 | 247,644 | SH | SOLE | 247,644 | 0 | 0 | ||
| Centessa Pharmaceuticals plc | SPONSORED ADS | 152309100 | 19,622,576 | 1,227,178 | SH | SOLE | 1,227,178 | 0 | 0 | ||
| Century Therapeutics, Inc. | COM | 15673T100 | 1,363,657 | 797,460 | SH | SOLE | 797,460 | 0 | 0 | ||
| Cerus Corporation | COM | 157085101 | 33,890,570 | 19,477,339 | SH | SOLE | 19,477,339 | 0 | 0 | ||
| Compass Therapeutics, Inc. | COM | 20454B104 | 2,866,039 | 1,557,630 | SH | SOLE | 1,557,630 | 0 | 0 | ||
| Contineum Therapeutics, Inc. | CL A | 21217B100 | 5,981,250 | 312,500 | SH | SOLE | 312,500 | 0 | 0 | ||
| Crinetics Pharmaceuticals, Inc. | COM | 22663K107 | 5,310,670 | 103,927 | SH | SOLE | 103,927 | 0 | 0 | ||
| CRISPR Therapeutics AG | NAMEN AKT | H17182108 | 39,607,664 | 843,075 | SH | SOLE | 843,075 | 0 | 0 | ||
| DBV Technologies S.A. | SPONSORED ADR | 23306J200 | 5,114,992 | 7,307,131 | SH | SOLE | 7,307,131 | 0 | 0 | ||
| Denali Therapeutics Inc. | COM | 24823R105 | 108,704,275 | 3,731,695 | SH | SOLE | 3,731,695 | 0 | 0 | ||
| Design Therapeutics, Inc. | COM | 25056L103 | 9,381,241 | 1,743,725 | SH | SOLE | 1,743,725 | 0 | 0 | ||
| Dyne Therapeutics, Inc. | COM | 26818M108 | 24,141,688 | 672,096 | SH | SOLE | 672,096 | 0 | 0 | ||
| Edgewise Therapeutics, Inc. | COM | 28036F105 | 155,871,175 | 5,840,059 | SH | SOLE | 5,840,059 | 0 | 0 | ||
| Enliven Therapeutics, Inc. | COM | 29337E102 | 2,932,835 | 114,833 | SH | SOLE | 114,833 | 0 | 0 | ||
| Entrada Therapeutics, Inc. | COM | 29384C108 | 77,755,788 | 4,865,819 | SH | SOLE | 4,865,819 | 0 | 0 | ||
| Fate Therapeutics, Inc. | COM | 31189P102 | 10,492,202 | 2,997,772 | SH | SOLE | 2,997,772 | 0 | 0 | ||
| Foghorn Therapeutics Inc. | COM | 344174107 | 419,201 | 45,027 | SH | SOLE | 45,027 | 0 | 0 | ||
| Generation Bio Co. | COM | 37148K100 | 4,804,014 | 1,944,945 | SH | SOLE | 1,944,945 | 0 | 0 | ||
| HOOKIPA Pharma Inc. | COM | 43906K209 | 3,495,100 | 812,814 | SH | SOLE | 812,814 | 0 | 0 | ||
| IDEAYA Biosciences, Inc. | COM | 45166A102 | 33,648,057 | 1,062,123 | SH | SOLE | 1,062,123 | 0 | 0 | ||
| IGM Biosciences, Inc. | COM | 449585108 | 67,686,807 | 4,092,310 | SH | SOLE | 4,092,310 | 0 | 0 | ||
| Immatics N.V. | SHS | N44445109 | 73,519,171 | 6,443,398 | SH | SOLE | 6,443,398 | 0 | 0 | ||
| Immunocore Holdings plc | ADS | 45258D105 | 47,171,849 | 1,515,318 | SH | SOLE | 1,515,318 | 0 | 0 | ||
| Immunovant, Inc. | COM | 45258J102 | 34,936,439 | 1,225,410 | SH | SOLE | 1,225,410 | 0 | 0 | ||
| Incyte Corporation | COM | 45337C102 | 2,031,849,222 | 30,739,020 | SH | SOLE | 30,739,020 | 0 | 0 | ||
| Insmed Incorporated | COM PAR $.01 | 457669307 | 322,362,014 | 4,415,918 | SH | SOLE | 4,415,918 | 0 | 0 | ||
| Ionis Pharmaceuticals, Inc. | COM | 462222100 | 8,952,208 | 223,470 | SH | SOLE | 223,470 | 0 | 0 | ||
| KALA BIO, Inc. | COM | 483119202 | 5,080,610 | 891,335 | SH | SOLE | 891,335 | 0 | 0 | ||
| Kiniksa Pharmaceuticals International, plc | ORD SHS CL A | G52694109 | 70,429,892 | 2,818,323 | SH | SOLE | 2,818,323 | 0 | 0 | ||
| Kodiak Sciences Inc. | COM | 50015M109 | 45,180,379 | 17,310,490 | SH | SOLE | 17,310,490 | 0 | 0 | ||
| Krystal Biotech, Inc. | COM | 501147102 | 30,933,086 | 169,934 | SH | SOLE | 169,934 | 0 | 0 | ||
| Kymera Therapeutics, Inc. | COM | 501575104 | 283,787,320 | 5,995,929 | SH | SOLE | 5,995,929 | 0 | 0 | ||
| Leap Therapeutics, Inc. | COM | 52187K200 | 3,012,490 | 1,172,175 | SH | SOLE | 1,172,175 | 0 | 0 | ||
| Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 419,047,490 | 1,974,590 | SH | SOLE | 1,974,590 | 0 | 0 | ||
| Mersana Therapeutics, Inc. | COM | 59045L106 | 2,052,757 | 1,086,115 | SH | SOLE | 1,086,115 | 0 | 0 | ||
| Merus N.V. | COM | N5749R100 | 14,988,000 | 300,000 | SH | SOLE | 300,000 | 0 | 0 | ||
| Mirum Pharmaceuticals, Inc. | COM | 604749101 | 7,428,564 | 190,476 | SH | SOLE | 190,476 | 0 | 0 | ||
| Monte Rosa Therapeutics, Inc. | COM | 61225M102 | 26,055,304 | 4,916,095 | SH | SOLE | 4,916,095 | 0 | 0 | ||
| Neumora Therapeutics, Inc. | COM | 640979100 | 13,667,066 | 1,034,600 | SH | SOLE | 1,034,600 | 0 | 0 | ||
| Neurogene Inc. | COM | 64135M105 | 19,134,389 | 456,015 | SH | SOLE | 456,015 | 0 | 0 | ||
| NewAmsterdam Pharma Company N.V. | ORDINARY SHARES | N62509109 | 1,605,403 | 96,711 | SH | SOLE | 96,711 | 0 | 0 | ||
| Nurix Therapeutics, Inc. | COM | 67080M103 | 87,231,349 | 3,882,125 | SH | SOLE | 3,882,125 | 0 | 0 | ||
| Opthea Limited | SPONSORED ADS | 68386J208 | 8,846,642 | 2,173,622 | SH | SOLE | 2,173,622 | 0 | 0 | ||
| Pfizer Inc. | COM | 717081103 | 1,012,900 | 35,000 | SH | SOLE | 35,000 | 0 | 0 | ||
| PMV Pharmaceuticals, Inc. | COM | 69353Y103 | 479,816 | 322,024 | SH | SOLE | 322,024 | 0 | 0 | ||
| Praxis Precision Medicines, Inc. | COM | 74006W207 | 18,591,462 | 323,105 | SH | SOLE | 323,105 | 0 | 0 | ||
| Prelude Therapeutics Inc. | COM | 74065P101 | 20,956,316 | 10,123,824 | SH | SOLE | 10,123,824 | 0 | 0 | ||
| Prime Medicine, Inc. | COM | 74168J101 | 3,980,163 | 1,028,466 | SH | SOLE | 1,028,466 | 0 | 0 | ||
| Protara Therapeutics, Inc. | COM STK | 74365U107 | 982,403 | 536,832 | SH | SOLE | 536,832 | 0 | 0 | ||
| Relay Therapeutics, Inc. | COM | 75943R102 | 8,213,628 | 1,160,117 | SH | SOLE | 1,160,117 | 0 | 0 | ||
| Replimune Group, Inc. | COM | 76029N106 | 121,056,883 | 11,045,336 | SH | SOLE | 11,045,336 | 0 | 0 | ||
| Revolution Medicines, Inc. | COM | 76155X100 | 343,258,232 | 7,569,090 | SH | SOLE | 7,569,090 | 0 | 0 | ||
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | 335,210,395 | 6,398,366 | SH | SOLE | 6,398,366 | 0 | 0 | ||
| Roivant Sciences Ltd. | SHS | G76279101 | 32,297,183 | 2,798,716 | SH | SOLE | 2,798,716 | 0 | 0 | ||
| Sagimet Biosciences Inc. | COM SER A | 786700104 | 3,827,857 | 1,381,898 | SH | SOLE | 1,381,898 | 0 | 0 | ||
| Sana Biotechnology, Inc. | COM | 799566104 | 9,904,748 | 2,380,949 | SH | SOLE | 2,380,949 | 0 | 0 | ||
| Sera Prognostics, Inc. | CLASS A COM | 81749D107 | 42,388,312 | 5,434,399 | SH | SOLE | 5,434,399 | 0 | 0 | ||
| Skye Bioscience, Inc. | COM | 83086J200 | 5,609,419 | 1,434,634 | SH | SOLE | 1,434,634 | 0 | 0 | ||
| Stoke Therapeutics, Inc. | COM | 86150R107 | 53,688,164 | 4,368,443 | SH | SOLE | 4,368,443 | 0 | 0 | ||
| Structure Therapeutics Inc. | SPONSORED ADS | 86366E106 | 3,752,595 | 85,500 | SH | SOLE | 85,500 | 0 | 0 | ||
| Summit Therapeutics Inc. | COM | 86627T108 | 534,904,544 | 24,424,865 | SH | SOLE | 24,424,865 | 0 | 0 | ||
| Surrozen, Inc. | W EXP 8/11/2026 | 86889P117 | 8,583 | 833,333 | SH | SOLE | 833,333 | 0 | 0 | ||
| Tango Therapeutics, Inc. | COM | 87583X109 | 5,775,000 | 750,000 | SH | SOLE | 750,000 | 0 | 0 | ||
| Taysha Gene Therapies, Inc. | COM SHS | 877619106 | 8,049,560 | 4,004,756 | SH | SOLE | 4,004,756 | 0 | 0 | ||
| TScan Therapeutics, Inc. | COM | 89854M101 | 13,868,264 | 2,784,792 | SH | SOLE | 2,784,792 | 0 | 0 | ||
| Tyra Biosciences, Inc. | COM | 90240B106 | 249,371 | 10,607 | SH | SOLE | 10,607 | 0 | 0 | ||
| Ultragenyx Pharmaceutical Inc. | COM | 90400D108 | 87,553,133 | 1,576,114 | SH | SOLE | 1,576,114 | 0 | 0 | ||
| Vaxcyte, Inc. | COM | 92243G108 | 5,586,089 | 48,885 | SH | SOLE | 48,885 | 0 | 0 | ||
| Verve Therapeutics, Inc. | COM | 92539P101 | 8,187,005 | 1,691,530 | SH | SOLE | 1,691,530 | 0 | 0 | ||
| vTv Therapeutics, Inc. | CL A | 918385204 | 1,320,064 | 97,314 | SH | SOLE | 97,314 | 0 | 0 | ||
| Wave Life Sciences Ltd. | SHS | Y95308105 | 2,821,317 | 344,063 | SH | SOLE | 344,063 | 0 | 0 | ||
| Xencor, Inc. | COM | 98401F105 | 13,482,367 | 670,431 | SH | SOLE | 670,431 | 0 | 0 | ||
| Xenon Pharmaceuticals Inc. | COM | 98420N105 | 39,121,142 | 993,679 | SH | SOLE | 993,679 | 0 | 0 | ||
| Insmed Incorporated | Note 0.75% 6/1/2028 | 457669AB5 | 98,325,495 | 42,850,000 | PRN | SOLE | 42,850,000 | 0 | 0 | ||
