The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete. | |||||||||||||||||||||
| UNITED STATES SECURITIES AND EXCHANGE COMMISSION Washington, D.C. 20549 FORM 13F FORM 13F INFORMATION TABLE |
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| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 | ||||
| VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY | |||||
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| 2seventy bio, Inc. | COMMON STOCK | 901384107 | 7,342,726 | 2,497,526 | SH | SOLE | 2,497,526 | 0 | 0 | ||
| AbCellera Biologics Inc. | COM | 00288U106 | 80,650,125 | 27,525,640 | SH | SOLE | 27,525,640 | 0 | 0 | ||
| ACADIA Pharmaceuticals Inc. | COM | 004225108 | 786,809,759 | 42,877,916 | SH | SOLE | 42,877,916 | 0 | 0 | ||
| Acrivon Therapeutics, Inc. | COMMON STOCK | 004890109 | 318,368 | 52,885 | SH | SOLE | 52,885 | 0 | 0 | ||
| Akero Therapeutics, Inc. | COM | 00973Y108 | 30,520,821 | 1,097,082 | SH | SOLE | 1,097,082 | 0 | 0 | ||
| Aligos Therapeutics, Inc. | COM | 01626L204 | 3,308,911 | 83,055 | SH | SOLE | 83,055 | 0 | 0 | ||
| Alkermes plc | SHS | G01767105 | 120,267,159 | 4,181,751 | SH | SOLE | 4,181,751 | 0 | 0 | ||
| Alumis Inc. | COM | 022307102 | 12,281,250 | 1,562,500 | SH | SOLE | 1,562,500 | 0 | 0 | ||
| Arcturus Therapeutics Holdings Inc. | COM | 03969T109 | 2,568,053 | 151,329 | SH | SOLE | 151,329 | 0 | 0 | ||
| argenx SE | SPONSORED ADR | 04016X101 | 68,820,960 | 111,904 | SH | SOLE | 111,904 | 0 | 0 | ||
| Arvinas, Inc. | COM | 04335A105 | 7,774,892 | 405,576 | SH | SOLE | 405,576 | 0 | 0 | ||
| BeiGene, Ltd. | SPONSORED ADR | 07725L102 | 1,760,633,555 | 9,531,880 | SH | SOLE | 9,531,880 | 0 | 0 | ||
| Bicara Therapeutics Inc. | COM | 055477103 | 14,516,661 | 833,333 | SH | SOLE | 833,333 | 0 | 0 | ||
| Bicycle Therapeutics plc | SPONSORED ADS | 088786108 | 152,394,998 | 10,885,357 | SH | SOLE | 10,885,357 | 0 | 0 | ||
| Biomea Fusion, Inc. | COM | 09077A106 | 5,633,721 | 1,451,990 | SH | SOLE | 1,451,990 | 0 | 0 | ||
| BioNTech SE | SPONSORED ADS | 09075V102 | 5,131,282 | 45,031 | SH | SOLE | 45,031 | 0 | 0 | ||
| Candel Therapeutics, Inc. | COM | 137404109 | 25,883,612 | 2,981,983 | SH | SOLE | 2,981,983 | 0 | 0 | ||
| Celcuity Inc. | COM | 15102K100 | 35,062,259 | 2,678,553 | SH | SOLE | 2,678,553 | 0 | 0 | ||
| Celldex Therapeutics, Inc. | COM | 15117B202 | 6,257,964 | 247,644 | SH | SOLE | 247,644 | 0 | 0 | ||
| Centessa Pharmaceuticals plc | SPONSORED ADS | 152309100 | 20,555,232 | 1,227,178 | SH | SOLE | 1,227,178 | 0 | 0 | ||
| Century Therapeutics, Inc. | COM | 15673T100 | 805,435 | 797,460 | SH | SOLE | 797,460 | 0 | 0 | ||
| Cerus Corporation | COM | 157085101 | 29,995,102 | 19,477,339 | SH | SOLE | 19,477,339 | 0 | 0 | ||
| Compass Therapeutics, Inc. | COM | 20454B104 | 2,258,564 | 1,557,630 | SH | SOLE | 1,557,630 | 0 | 0 | ||
| Contineum Therapeutics, Inc. | CL A | 21217B100 | 4,578,125 | 312,500 | SH | SOLE | 312,500 | 0 | 0 | ||
| CRISPR Therapeutics AG | NAMEN AKT | H17182108 | 51,483,313 | 1,308,011 | SH | SOLE | 1,308,011 | 0 | 0 | ||
| DBV Technologies S.A. | SPONSORED ADS | 23306J309 | 4,515,803 | 1,461,425 | SH | SOLE | 1,461,425 | 0 | 0 | ||
| Denali Therapeutics Inc. | COM | 24823R105 | 76,051,944 | 3,731,695 | SH | SOLE | 3,731,695 | 0 | 0 | ||
| Design Therapeutics, Inc. | COM | 25056L103 | 10,758,783 | 1,743,725 | SH | SOLE | 1,743,725 | 0 | 0 | ||
| Disc Medicine, Inc. | COM | 254604101 | 4,884,970 | 77,050 | SH | SOLE | 77,050 | 0 | 0 | ||
| Dyne Therapeutics, Inc. | COM | 26818M108 | 15,834,582 | 672,096 | SH | SOLE | 672,096 | 0 | 0 | ||
| Edgewise Therapeutics, Inc. | COM | 28036F105 | 164,363,598 | 6,155,940 | SH | SOLE | 6,155,940 | 0 | 0 | ||
| Enliven Therapeutics, Inc. | COM | 29337E102 | 2,583,743 | 114,833 | SH | SOLE | 114,833 | 0 | 0 | ||
| Entrada Therapeutics, Inc. | COM | 29384C108 | 84,130,011 | 4,865,819 | SH | SOLE | 4,865,819 | 0 | 0 | ||
| Fate Therapeutics, Inc. | COM | 31189P102 | 5,376,363 | 3,258,402 | SH | SOLE | 3,258,402 | 0 | 0 | ||
| Foghorn Therapeutics Inc. | COM | 344174107 | 212,527 | 45,027 | SH | SOLE | 45,027 | 0 | 0 | ||
| Generation Bio Co. | COM | 37148K100 | 2,061,642 | 1,944,945 | SH | SOLE | 1,944,945 | 0 | 0 | ||
| GRAIL, Inc. | COM | 384747101 | 29,097,731 | 1,630,125 | SH | SOLE | 1,630,125 | 0 | 0 | ||
| HOOKIPA Pharma Inc. | COM | 43906K209 | 1,633,756 | 812,814 | SH | SOLE | 812,814 | 0 | 0 | ||
| IDEAYA Biosciences, Inc. | COM | 45166A102 | 27,296,561 | 1,062,123 | SH | SOLE | 1,062,123 | 0 | 0 | ||
| IGM Biosciences, Inc. | COM | 449585108 | 25,016,197 | 4,094,304 | SH | SOLE | 4,094,304 | 0 | 0 | ||
| Immatics N.V. | SHS | N44445109 | 51,731,151 | 7,275,830 | SH | SOLE | 7,275,830 | 0 | 0 | ||
| Immunocore Holdings plc | ADS | 45258D105 | 44,701,881 | 1,515,318 | SH | SOLE | 1,515,318 | 0 | 0 | ||
| Immunovant, Inc. | COM | 45258J102 | 42,304,212 | 1,707,881 | SH | SOLE | 1,707,881 | 0 | 0 | ||
| Incyte Corporation | COM | 45337C102 | 2,123,174,917 | 30,739,466 | SH | SOLE | 30,739,466 | 0 | 0 | ||
| Insmed Incorporated | COM PAR $.01 | 457669307 | 345,673,822 | 5,006,863 | SH | SOLE | 5,006,863 | 0 | 0 | ||
| Intellia Therapeutics, Inc. | COM | 45826J105 | 7,510,393 | 644,116 | SH | SOLE | 644,116 | 0 | 0 | ||
| Ionis Pharmaceuticals, Inc. | COM | 462222100 | 12,512,708 | 357,915 | SH | SOLE | 357,915 | 0 | 0 | ||
| KALA BIO, Inc. | COM | 483119202 | 8,341,144 | 1,201,894 | SH | SOLE | 1,201,894 | 0 | 0 | ||
| Kiniksa Pharmaceuticals International, plc | ORD SHS CL A | G52694109 | 55,746,429 | 2,818,323 | SH | SOLE | 2,818,323 | 0 | 0 | ||
| Kodiak Sciences Inc. | COM | 50015M109 | 172,239,376 | 17,310,490 | SH | SOLE | 17,310,490 | 0 | 0 | ||
| Krystal Biotech, Inc. | COM | 501147102 | 26,621,860 | 169,934 | SH | SOLE | 169,934 | 0 | 0 | ||
| Kymera Therapeutics, Inc. | COM | 501575104 | 241,216,224 | 5,995,929 | SH | SOLE | 5,995,929 | 0 | 0 | ||
| Leap Therapeutics, Inc. | COM | 52187K200 | 3,370,003 | 1,172,175 | SH | SOLE | 1,172,175 | 0 | 0 | ||
| Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 609,299,236 | 1,974,590 | SH | SOLE | 1,974,590 | 0 | 0 | ||
| Mersana Therapeutics, Inc. | COM | 59045L106 | 1,553,144 | 1,086,115 | SH | SOLE | 1,086,115 | 0 | 0 | ||
| Merus N.V. | COM | N5749R100 | 18,922,500 | 450,000 | SH | SOLE | 450,000 | 0 | 0 | ||
| Mirum Pharmaceuticals, Inc. | COM | 604749101 | 7,876,183 | 190,476 | SH | SOLE | 190,476 | 0 | 0 | ||
| Monte Rosa Therapeutics, Inc. | COM | 61225M102 | 34,117,699 | 4,916,095 | SH | SOLE | 4,916,095 | 0 | 0 | ||
| Neumora Therapeutics, Inc. | COM | 640979100 | 10,966,760 | 1,034,600 | SH | SOLE | 1,034,600 | 0 | 0 | ||
| Neurogene Inc. | COM | 64135M105 | 15,417,927 | 674,450 | SH | SOLE | 674,450 | 0 | 0 | ||
| Nurix Therapeutics, Inc. | COM | 67080M103 | 73,139,235 | 3,882,125 | SH | SOLE | 3,882,125 | 0 | 0 | ||
| Opthea Limited | SPONSORED ADS | 68386J208 | 8,536,900 | 2,173,622 | SH | SOLE | 2,173,622 | 0 | 0 | ||
| PMV Pharmaceuticals, Inc. | COM | 69353Y103 | 486,256 | 322,024 | SH | SOLE | 322,024 | 0 | 0 | ||
| Praxis Precision Medicines, Inc. | COM | 74006W207 | 25,514,780 | 331,533 | SH | SOLE | 331,533 | 0 | 0 | ||
| Prelude Therapeutics Inc. | COM | 74065P101 | 12,907,876 | 10,123,824 | SH | SOLE | 10,123,824 | 0 | 0 | ||
| Prime Medicine, Inc. | COM | 74168J101 | 3,003,121 | 1,028,466 | SH | SOLE | 1,028,466 | 0 | 0 | ||
| Protara Therapeutics, Inc. | COM STK | 74365U107 | 2,834,473 | 536,832 | SH | SOLE | 536,832 | 0 | 0 | ||
| PTC Therapeutics, Inc. | COM | 69366J200 | 920,856 | 20,400 | SH | SOLE | 20,400 | 0 | 0 | ||
| Relay Therapeutics, Inc. | COM | 75943R102 | 4,779,682 | 1,160,117 | SH | SOLE | 1,160,117 | 0 | 0 | ||
| Replimune Group, Inc. | COM | 76029N106 | 133,759,019 | 11,045,336 | SH | SOLE | 11,045,336 | 0 | 0 | ||
| Revolution Medicines, Inc. | COM | 76155X100 | 347,163,155 | 7,936,972 | SH | SOLE | 7,936,972 | 0 | 0 | ||
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | 340,596,259 | 6,084,249 | SH | SOLE | 6,084,249 | 0 | 0 | ||
| Rocket Pharmaceuticals, Inc. | COM | 77313F106 | 1,220,283 | 97,079 | SH | SOLE | 97,079 | 0 | 0 | ||
| Roivant Sciences Ltd. | SHS | G76279101 | 44,572,755 | 3,767,773 | SH | SOLE | 3,767,773 | 0 | 0 | ||
| Sagimet Biosciences Inc. | COM SER A | 786700104 | 4,288,482 | 952,996 | SH | SOLE | 952,996 | 0 | 0 | ||
| Sana Biotechnology, Inc. | COM | 799566104 | 3,880,947 | 2,380,949 | SH | SOLE | 2,380,949 | 0 | 0 | ||
| Sera Prognostics, Inc. | CLASS A COM | 81749D107 | 44,236,008 | 5,434,399 | SH | SOLE | 5,434,399 | 0 | 0 | ||
| Skye Bioscience, Inc. | COM | 83086J200 | 4,105,306 | 1,450,638 | SH | SOLE | 1,450,638 | 0 | 0 | ||
| Stoke Therapeutics, Inc. | COM | 86150R107 | 51,111,233 | 4,633,838 | SH | SOLE | 4,633,838 | 0 | 0 | ||
| Structure Therapeutics Inc. | SPONSORED ADS | 86366E106 | 9,805,643 | 361,565 | SH | SOLE | 361,565 | 0 | 0 | ||
| Summit Therapeutics Inc. | COM | 86627T108 | 435,861,716 | 24,424,865 | SH | SOLE | 24,424,865 | 0 | 0 | ||
| Surrozen, Inc. | W EXP 8/11/2026 | 86889P117 | 17,833 | 833,333 | SH | SOLE | 833,333 | 0 | 0 | ||
| Taysha Gene Therapies, Inc. | COM SHS | 877619106 | 6,928,228 | 4,004,756 | SH | SOLE | 4,004,756 | 0 | 0 | ||
| TScan Therapeutics, Inc. | COM | 89854M101 | 8,465,768 | 2,784,792 | SH | SOLE | 2,784,792 | 0 | 0 | ||
| Tyra Biosciences, Inc. | COM | 90240B106 | 147,437 | 10,607 | SH | SOLE | 10,607 | 0 | 0 | ||
| Ultragenyx Pharmaceutical Inc. | COM | 90400D108 | 66,307,116 | 1,576,114 | SH | SOLE | 1,576,114 | 0 | 0 | ||
| Vaxcyte, Inc. | COM | 92243G108 | 4,001,726 | 48,885 | SH | SOLE | 48,885 | 0 | 0 | ||
| Verve Therapeutics, Inc. | COM | 92539P101 | 9,540,229 | 1,691,530 | SH | SOLE | 1,691,530 | 0 | 0 | ||
| Vir Biotechnology, Inc. | COM | 92764N102 | 7,960,516 | 1,084,539 | SH | SOLE | 1,084,539 | 0 | 0 | ||
| vTv Therapeutics, Inc. | CL A | 918385204 | 1,343,780 | 97,314 | SH | SOLE | 97,314 | 0 | 0 | ||
| Wave Life Sciences Ltd. | SHS | Y95308105 | 4,256,059 | 344,063 | SH | SOLE | 344,063 | 0 | 0 | ||
| Xencor, Inc. | COM | 98401F105 | 15,406,504 | 670,431 | SH | SOLE | 670,431 | 0 | 0 | ||
| Xenon Pharmaceuticals Inc. | COM | 98420N105 | 38,952,217 | 993,679 | SH | SOLE | 993,679 | 0 | 0 | ||
| Insmed Incorporated | Note 0.75% 6/1/2028 | 457669AB5 | 92,928,709 | 42,850,000 | PRN | SOLE | 42,850,000 | 0 | 0 | ||
| Ionis Pharmaceuticals, Inc. | Note 1.75% 6/15/2028 | 462222AF7 | 29,543,640 | 30,000,000 | PRN | SOLE | 30,000,000 | 0 | 0 | ||
