Baker Bros. Advisors 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Abeona Therapeutics Inc.	COM	00289Y107	34,950	2,184,364	SH		SOLE		2,184,364	0	0
ACADIA Pharmaceuticals Inc.	COM	004225108	415,777	27,228,338	SH		SOLE		27,228,338	0	0
Acceleron Pharma Inc.	COM	00434H108	7,952	163,900	SH		SOLE		163,900	0	0
Achillion Pharmaceuticals, Inc.	COM	00448Q201	5,500	1,943,620	SH		SOLE		1,943,620	0	0
Acorda Therapeutics, Inc.	COM	00484M106	4,968	173,100	SH		SOLE		173,100	0	0
Adamas Pharmaceuticals, Inc.	COM	00548A106	4,459	172,630	SH		SOLE		172,630	0	0
Adaptimmune Therapeutics plc	SPONSORED ADR	00653A107	1,187	100,000	SH		SOLE		100,000	0	0
Aeglea BioTherapeutics, Inc.	COM	00773J103	14,684	1,387,872	SH		SOLE		1,387,872	0	0
Aerie Pharmaceuticals, Inc.	COM	00771V108	4,063	60,155	SH		SOLE		60,155	0	0
Aevi Genomic Medicine, Inc.	COM	00835P105	4,501	4,055,142	SH		SOLE		4,055,142	0	0
Affimed N.V.	COM	N01045108	660	400,000	SH		SOLE		400,000	0	0
Aimmune Therapeutics, Inc.	COM	00900T107	18,121	673,908	SH		SOLE		673,908	0	0
Akari Therapeutics, Plc	SPONSORED ADR	00972G108	115	58,770	SH		SOLE		58,770	0	0
Albireo Pharma, Inc.	COM	01345P106	8,875	250,000	SH		SOLE		250,000	0	0
Alexion Pharmaceuticals, Inc.	COM	015351109	1,062,214	8,555,894	SH		SOLE		8,555,894	0	0
Alkermes plc	SHS	G01767105	4,126	100,251	SH		SOLE		100,251	0	0
Amarin Corporation plc	SPONSORED ADR NEW	023111206	70,049	22,669,509	SH		SOLE		22,669,509	0	0
AnaptysBio, Inc.	COM	032724106	5,192	73,086	SH		SOLE		73,086	0	0
Apellis Pharmaceuticals, Inc.	COM	03753U106	4,314	196,078	SH		SOLE		196,078	0	0
Aquinox Pharmaceuticals, Inc.	COM	03842B101	28,976	10,934,154	SH		SOLE		10,934,154	0	0
Arbutus Biopharma Corporation	COM	03879J100	1,318	180,582	SH		SOLE		180,582	0	0
Arcus Biosciences, Inc.	COM	03969F109	1,488	121,534	SH		SOLE		121,534	0	0
argenx SE	SPONSORED ADR	04016X101	79,691	961,754	SH		SOLE		961,754	0	0
Array BioPharma Inc.	COM	04269X105	94,911	5,656,196	SH		SOLE		5,656,196	0	0
Ascendis Pharma A/S	SPONSORED ADR	04351P101	188,741	2,837,352	SH		SOLE		2,837,352	0	0
Assembly Biosciences, Inc.	COM	045396108	5,826	148,587	SH		SOLE		148,587	0	0
Audentes Therapeutics, Inc.	COM	05070R104	15,025	393,222	SH		SOLE		393,222	0	0
Autolus Therapeutics plc	SPON ADS	05280R100	6,304	235,294	SH		SOLE		235,294	0	0
BeiGene, Ltd.	SPONSORED ADR	07725L102	1,838,584	11,959,824	SH		SOLE		11,959,824	0	0
Bellicum Pharmaceuticals, Inc.	COM	079481107	30,210	4,093,447	SH		SOLE		4,093,447	0	0
BioCryst Pharmaceuticals, Inc.	COM	09058V103	80,290	14,012,172	SH		SOLE		14,012,172	0	0
BioDelivery Sciences International, Inc.	COM	09060J106	620	210,021	SH		SOLE		210,021	0	0
BioMarin Pharmaceutical Inc.	COM	09061G101	714,327	7,583,084	SH		SOLE		7,583,084	0	0
BioTime, Inc.	*W EXP 10/1/201	09066L162	1	20,084	SH		SOLE		20,084	0	0
bluebird bio, Inc.	COM	09609G100	31,390	200,000	SH		SOLE		200,000	0	0
Catalyst Pharmaceuticals, Inc.	COM	14888U101	11,301	3,621,962	SH		SOLE		3,621,962	0	0
Cellectis S.A.	SPONSORED ADS	15117K103	1,415	50,000	SH		SOLE		50,000	0	0
Cerus Corporation	COM	157085101	71,702	10,749,937	SH		SOLE		10,749,937	0	0
ChemoCentryx, Inc.	COM	16383L106	5,453	414,029	SH		SOLE		414,029	0	0
Clementia Pharmaceuticals Inc.	COM	185575107	15,695	1,192,595	SH		SOLE		1,192,595	0	0
ContraFect Corporation	COM	212326102	15,808	7,153,076	SH		SOLE		7,153,076	0	0
Corbus Pharmaceuticals Holdings, Inc.	COM	21833P103	1,250	247,450	SH		SOLE		247,450	0	0
Cyclacel Pharmaceuticals, Inc.	PFD CONV EX 6%	23254L207	89	13,253	SH		SOLE		13,253	0	0
CymaBay Therapeutics, Inc.	COM	23257D103	65,996	4,917,700	SH		SOLE		4,917,700	0	0
DBV Technologies S.A.	SPONSORED ADR	23306J101	106,279	5,509,560	SH		SOLE		5,509,560	0	0
Dynavax Technologies Corporation	COM NEW	268158201	1,144	75,000	SH		SOLE		75,000	0	0
Endocyte, Inc.	COM	29269A102	31,434	2,277,799	SH		SOLE		2,277,799	0	0
ERYTECH Pharma S.A.	SPONSORED ADR	29604W108	34,470	3,085,969	SH		SOLE		3,085,969	0	0
Exelixis, Inc.	COM	30161Q104	11,049	513,410	SH		SOLE		513,410	0	0
Foamix Pharmaceuticals Ltd.	SHS	M46135105	7,466	1,490,201	SH		SOLE		1,490,201	0	0
Forty Seven, Inc.	COM	34983P104	4,000	250,000	SH		SOLE		250,000	0	0
Fulgent Genetics, Inc.	COM	359664109	518	125,000	SH		SOLE		125,000	0	0
G1 Therapeutics, Inc.	COM	3621LQ109	7,366	169,492	SH		SOLE		169,492	0	0
Galapagos NV	SPONSORED ADR	36315X101	23,957	259,894	SH		SOLE		259,894	0	0
Galmed Pharmaceuticals Ltd.	SHS	M47238106	7,570	636,140	SH		SOLE		636,140	0	0
Genomic Health, Inc.	COM	37244C101	695,045	13,790,574	SH		SOLE		13,790,574	0	0
GlycoMimetics, Inc.	COM	38000Q102	4,697	291,214	SH		SOLE		291,214	0	0
GW Pharmaceuticals plc	ADS	36197T103	44,904	321,800	SH		SOLE		321,800	0	0
Halozyme Therapeutics, Inc.	COM	40637H109	21,660	1,283,929	SH		SOLE		1,283,929	0	0
Heron Therapeutics, Inc.	COM	427746102	195,233	5,025,298	SH		SOLE		5,025,298	0	0
Idera Pharmaceuticals, Inc.	COM NEW	45168K405	51,024	38,654,811	SH		SOLE		38,654,811	0	0
Incyte Corporation	COM	45337C102	2,294,819	34,251,034	SH		SOLE		34,251,034	0	0
Infinity Pharmaceuticals, Inc.	COM	45665G303	1,109	580,400	SH		SOLE		580,400	0	0
InflaRx N.V.	COM	N44821101	8,347	258,824	SH		SOLE		258,824	0	0
Insmed Incorporated	COM PAR $.01	457669307	16,555	700,000	SH		SOLE		700,000	0	0
Intellia Therapeutics, Inc.	COM	45826J105	14,964	546,922	SH		SOLE		546,922	0	0
Invitae Corporation	COM	46185L103	61,736	8,399,411	SH		SOLE		8,399,411	0	0
Jounce Therapeutics, Inc.	COM	481116101	766	100,000	SH		SOLE		100,000	0	0
Kiniksa Pharmaceuticals, Ltd.	COM CL A	G5269C101	52,050	3,000,000	SH		SOLE		3,000,000	0	0
Krystal Biotech, Inc.	COM	501147102	2,974	200,000	SH		SOLE		200,000	0	0
La Jolla Pharmaceutical Company	COM PAR $.0001 2	503459604	4,512	154,675	SH		SOLE		154,675	0	0
MacroGenics, Inc.	COM	556099109	4,495	217,695	SH		SOLE		217,695	0	0
Madrigal Pharmaceuticals, Inc.	COM	558868105	327,035	1,169,278	SH		SOLE		1,169,278	0	0
MediWound Ltd.	ORD SHS	M68830104	1,559	226,000	SH		SOLE		226,000	0	0
Menlo Therapeutics Inc.	COM	586858102	5,684	700,000	SH		SOLE		700,000	0	0
Merus N.V.	COM	N5749R100	26,402	1,160,014	SH		SOLE		1,160,014	0	0
Mirati Therapeutics, Inc.	COM	60468T105	123,914	2,513,462	SH		SOLE		2,513,462	0	0
Molecular Templates, Inc.	COM	608550109	379	72,412	SH		SOLE		72,412	0	0
Momenta Pharmaceuticals, Inc.	COM	60877T100	6,309	308,500	SH		SOLE		308,500	0	0
MyoKardia, Inc.	COM	62857M105	21,504	433,121	SH		SOLE		433,121	0	0
Nabriva Therapeutics plc	SHS	G63637105	3,265	938,235	SH		SOLE		938,235	0	0
Natera, Inc.	COM	632307104	4,304	228,676	SH		SOLE		228,676	0	0
Neurocrine Biosciences, Inc.	COM	64125C109	92,800	944,624	SH		SOLE		944,624	0	0
NewLink Genetics Corporation	COM	651511107	2,415	507,273	SH		SOLE		507,273	0	0
Ovid Therapeutics Inc.	COM	690469101	1,932	247,733	SH		SOLE		247,733	0	0
Progenics Pharmaceuticals, Inc.	COM	743187106	7,871	979,016	SH		SOLE		979,016	0	0
Proteon Therapeutics, Inc.	COM	74371L109	732	298,591	SH		SOLE		298,591	0	0
Ra Pharmaceuticals, Inc.	COM	74933V108	1,771	177,952	SH		SOLE		177,952	0	0
Rhythm Pharmaceuticals, Inc.	COM	76243J105	84,658	2,708,200	SH		SOLE		2,708,200	0	0
Rigel Pharmaceuticals, Inc.	COM NEW	766559603	2,948	1,041,612	SH		SOLE		1,041,612	0	0
Ritter Pharmaceuticals, Inc.	COM NEW	767836307	720	279,999	SH		SOLE		279,999	0	0
Sage Therapeutics, Inc.	COM	78667J108	96,000	613,300	SH		SOLE		613,300	0	0
Sangamo Therapeutics, Inc.	COM	800677106	18,232	1,283,923	SH		SOLE		1,283,923	0	0
Seattle Genetics, Inc.	COM	812578102	3,388,948	51,046,060	SH		SOLE		51,046,060	0	0
Selecta Biosciences, Inc.	COM	816212104	1,242	93,750	SH		SOLE		93,750	0	0
Sesen Bio, Inc.	COM	817763105	5,118	2,624,412	SH		SOLE		2,624,412	0	0
Solid Biosciences Inc.	COM	83422E105	20,946	587,884	SH		SOLE		587,884	0	0
Spark Therapeutics, Inc.	COM	84652J103	114,551	1,384,130	SH		SOLE		1,384,130	0	0
Spring Bank Pharmaceuticals, Inc.	COM	849431101	4,422	373,144	SH		SOLE		373,144	0	0
Stemline Therapeutics, Inc.	COM	85858C107	715	44,524	SH		SOLE		44,524	0	0
Sunesis Pharmaceuticals, Inc.	COM PAR	867328700	1,180	556,665	SH		SOLE		556,665	0	0
Syros Pharmaceuticals, Inc.	COM	87184Q107	5,869	574,835	SH		SOLE		574,835	0	0
T2 Biosystems, Inc.	COM	89853L104	774	100,000	SH		SOLE		100,000	0	0
Tetraphase Pharmaceuticals, Inc.	COM	88165N105	3,338	935,000	SH		SOLE		935,000	0	0
Tonix Pharmaceuticals Holdings Corp.	COM	890260409	3,113	699,500	SH		SOLE		699,500	0	0
Trevena, Inc.	COM	89532E109	1,368	950,000	SH		SOLE		950,000	0	0
Tricida, Inc.	COM	89610F101	47,840	1,600,000	SH		SOLE		1,600,000	0	0
Trillium Therapeutics Inc.	COM NEW	89620X506	3,071	511,763	SH		SOLE		511,763	0	0
uniQure N.V.	SHS	N90064101	22,869	605,000	SH		SOLE		605,000	0	0
Vanda Pharmaceuticals Inc.	COM	921659108	5,912	310,354	SH		SOLE		310,354	0	0
Versartis, Inc.	COM	92529L102	4,913	2,426,310	SH		SOLE		2,426,310	0	0
Xencor, Inc.	COM	98401F105	32,275	872,072	SH		SOLE		872,072	0	0
Zymeworks Inc.	COM	98985W102	19,378	1,311,085	SH		SOLE		1,311,085	0	0
Aegerion Pharmaceuticals, Inc.	NOTE 2% 8/15/2019	00767EAB8	6,027	9,517,000	PRN		SOLE		9,517,000	0	0
BioMarin Pharmaceutical Inc.	NOTE 0.75% 10/15/2018	09061GAE1	13,000	12,228,000	PRN		SOLE		12,228,000	0	0
BioMarin Pharmaceutical Inc.	NOTE 0.599% 8/1/2024	09061GAH4	15,198	15,000,000	PRN		SOLE		15,000,000	0	0
Corsicanto II Designated Activity Company	NOTE 3.5% 1/5/2047	220485AB2	10,908	10,000,000	PRN		SOLE		10,000,000	0	0
Neurocrine Biosciences, Inc.	NOTE 2.25% 5/15/2024	64125CAD1	14,466	10,000,000	PRN		SOLE		10,000,000	0	0
Novavax, Inc.	NOTE 3.75% 2/1/23	670002AB0	42,667	73,500,000	PRN		SOLE		73,500,000	0	0