| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Abeona Therapeutics Inc. | COM | 00289Y107 | 27,960 | 2,184,364 | SH | | SOLE | | 2,184,364 | 0 | 0 |
| ACADIA Pharmaceuticals Inc. | COM | 004225108 | 590,396 | 28,439,114 | SH | | SOLE | | 28,439,114 | 0 | 0 |
| Acceleron Pharma Inc. | COM | 00434H108 | 4,802 | 83,900 | SH | | SOLE | | 83,900 | 0 | 0 |
| Achillion Pharmaceuticals, Inc. | COM | 00448Q201 | 6,035 | 1,639,948 | SH | | SOLE | | 1,639,948 | 0 | 0 |
| Adamas Pharmaceuticals, Inc. | COM | 00548A106 | 3,456 | 172,630 | SH | | SOLE | | 172,630 | 0 | 0 |
| Aeglea BioTherapeutics, Inc. | COM | 00773J103 | 13,282 | 1,387,872 | SH | | SOLE | | 1,387,872 | 0 | 0 |
| Aevi Genomic Medicine, Inc. | COM | 00835P105 | 4,859 | 3,950,419 | SH | | SOLE | | 3,950,419 | 0 | 0 |
| Affimed N.V. | COM | N01045108 | 870 | 200,000 | SH | | SOLE | | 200,000 | 0 | 0 |
| Aimmune Therapeutics, Inc. | COM | 00900T107 | 18,384 | 673,908 | SH | | SOLE | | 673,908 | 0 | 0 |
| Albireo Pharma, Inc. | COM | 01345P106 | 8,240 | 250,000 | SH | | SOLE | | 250,000 | 0 | 0 |
| Alexion Pharmaceuticals, Inc. | COM | 015351109 | 1,189,355 | 8,555,894 | SH | | SOLE | | 8,555,894 | 0 | 0 |
| Alkermes plc | SHS | G01767105 | 4,255 | 100,251 | SH | | SOLE | | 100,251 | 0 | 0 |
| Amarin Corporation plc | SPONSORED ADR | 023111206 | 554,311 | 34,069,509 | SH | | SOLE | | 34,069,509 | 0 | 0 |
| AnaptysBio, Inc. | COM | 032724106 | 11,283 | 113,086 | SH | | SOLE | | 113,086 | 0 | 0 |
| Apellis Pharmaceuticals, Inc. | COM | 03753U106 | 3,486 | 196,078 | SH | | SOLE | | 196,078 | 0 | 0 |
| Aquestive Therapeutics, Inc. | COM | 03843E104 | 1,744 | 99,600 | SH | | SOLE | | 99,600 | 0 | 0 |
| Aquinox Pharmaceuticals, Inc. | COM | 03842B101 | 32,037 | 10,934,154 | SH | | SOLE | | 10,934,154 | 0 | 0 |
| Arcus Biosciences, Inc. | COM | 03969F109 | 1,694 | 121,534 | SH | | SOLE | | 121,534 | 0 | 0 |
| argenx SE | SPONSORED ADR | 04016X101 | 77,323 | 1,019,557 | SH | | SOLE | | 1,019,557 | 0 | 0 |
| Array BioPharma Inc. | COM | 04269X105 | 85,974 | 5,656,196 | SH | | SOLE | | 5,656,196 | 0 | 0 |
| Arrowhead Pharmaceuticals, Inc. | COM | 04280A100 | 5,895 | 307,496 | SH | | SOLE | | 307,496 | 0 | 0 |
| Ascendis Pharma A/S | SPONSORED ADR | 04351P101 | 201,055 | 2,837,352 | SH | | SOLE | | 2,837,352 | 0 | 0 |
| Assembly Biosciences, Inc. | COM | 045396108 | 5,519 | 148,587 | SH | | SOLE | | 148,587 | 0 | 0 |
| Audentes Therapeutics, Inc. | COM | 05070R104 | 15,568 | 393,222 | SH | | SOLE | | 393,222 | 0 | 0 |
| Autolus Therapeutics plc | SPON ADS | 05280R100 | 7,216 | 235,294 | SH | | SOLE | | 235,294 | 0 | 0 |
| BeiGene, Ltd. | SPONSORED ADR | 07725L102 | 2,059,721 | 11,959,824 | SH | | SOLE | | 11,959,824 | 0 | 0 |
| Bellicum Pharmaceuticals, Inc. | COM | 079481107 | 16,495 | 2,677,818 | SH | | SOLE | | 2,677,818 | 0 | 0 |
| BioCryst Pharmaceuticals, Inc. | COM | 09058V103 | 115,237 | 15,103,081 | SH | | SOLE | | 15,103,081 | 0 | 0 |
| BioMarin Pharmaceutical Inc. | COM | 09061G101 | 735,332 | 7,583,084 | SH | | SOLE | | 7,583,084 | 0 | 0 |
| bluebird bio, Inc. | COM | 09609G100 | 8,678 | 59,441 | SH | | SOLE | | 59,441 | 0 | 0 |
| Catalyst Pharmaceuticals, Inc. | COM | 14888U101 | 10,962 | 2,900,000 | SH | | SOLE | | 2,900,000 | 0 | 0 |
| Cerus Corporation | COM | 157085101 | 77,507 | 10,749,937 | SH | | SOLE | | 10,749,937 | 0 | 0 |
| ChemoCentryx, Inc. | COM | 16383L106 | 5,233 | 414,029 | SH | | SOLE | | 414,029 | 0 | 0 |
| Clementia Pharmaceuticals Inc. | COM | 185575107 | 21,560 | 1,933,624 | SH | | SOLE | | 1,933,624 | 0 | 0 |
| ContraFect Corporation | COM | 212326102 | 14,807 | 7,153,076 | SH | | SOLE | | 7,153,076 | 0 | 0 |
| Constellation Pharmaceuticals, Inc. | COM | 210373106 | 897 | 133,333 | SH | | SOLE | | 133,333 | 0 | 0 |
| Crinetics Pharmaceuticals, Inc. | COM | 22663K107 | 3,760 | 131,250 | SH | | SOLE | | 131,250 | 0 | 0 |
| CymaBay Therapeutics, Inc. | COM | 23257D103 | 54,488 | 4,917,700 | SH | | SOLE | | 4,917,700 | 0 | 0 |
| DBV Technologies S.A. | SPONSORED ADR | 23306J101 | 123,745 | 5,509,560 | SH | | SOLE | | 5,509,560 | 0 | 0 |
| Dynavax Technologies Corporation | COM | 268158201 | 930 | 75,000 | SH | | SOLE | | 75,000 | 0 | 0 |
| Endocyte, Inc. | COM | 29269A102 | 45,254 | 2,548,069 | SH | | SOLE | | 2,548,069 | 0 | 0 |
| ERYTECH Pharma S.A. | SPONSORED ADR | 29604W108 | 9,307 | 1,085,969 | SH | | SOLE | | 1,085,969 | 0 | 0 |
| Foamix Pharmaceuticals Ltd. | SHS | M46135105 | 3,943 | 688,075 | SH | | SOLE | | 688,075 | 0 | 0 |
| Forty Seven, Inc. | COM | 34983P104 | 3,730 | 250,000 | SH | | SOLE | | 250,000 | 0 | 0 |
| Fulgent Genetics, Inc. | COM | 359664109 | 491 | 125,000 | SH | | SOLE | | 125,000 | 0 | 0 |
| G1 Therapeutics, Inc. | COM | 3621LQ109 | 6,653 | 127,236 | SH | | SOLE | | 127,236 | 0 | 0 |
| Galapagos NV | SPONSORED ADR | 36315X101 | 26,667 | 237,191 | SH | | SOLE | | 237,191 | 0 | 0 |
| Galmed Pharmaceuticals Ltd. | SHS | M47238106 | 4,401 | 324,094 | SH | | SOLE | | 324,094 | 0 | 0 |
| Genomic Health, Inc. | COM | 37244C101 | 968,402 | 13,790,970 | SH | | SOLE | | 13,790,970 | 0 | 0 |
| GW Pharmaceuticals plc | ADS | 36197T103 | 68,526 | 396,700 | SH | | SOLE | | 396,700 | 0 | 0 |
| Halozyme Therapeutics, Inc. | COM | 40637H109 | 8,176 | 449,969 | SH | | SOLE | | 449,969 | 0 | 0 |
| Heron Therapeutics, Inc. | COM | 427746102 | 159,051 | 5,025,298 | SH | | SOLE | | 5,025,298 | 0 | 0 |
| Idera Pharmaceuticals, Inc. | COM | 45168K405 | 43,070 | 4,833,897 | SH | | SOLE | | 4,833,897 | 0 | 0 |
| Incyte Corporation | COM | 45337C102 | 2,366,080 | 34,251,309 | SH | | SOLE | | 34,251,309 | 0 | 0 |
| Infinity Pharmaceuticals, Inc. | COM | 45665G303 | 1,573 | 580,400 | SH | | SOLE | | 580,400 | 0 | 0 |
| InflaRx N.V. | COM | N44821101 | 6,143 | 178,987 | SH | | SOLE | | 178,987 | 0 | 0 |
| Insmed Incorporated | COM PAR $.01 | 457669307 | 37,447 | 1,851,982 | SH | | SOLE | | 1,851,982 | 0 | 0 |
| Intellia Therapeutics, Inc. | COM | 45826J105 | 5,510 | 192,538 | SH | | SOLE | | 192,538 | 0 | 0 |
| Invitae Corporation | COM | 46185L103 | 140,522 | 8,399,411 | SH | | SOLE | | 8,399,411 | 0 | 0 |
| Kiniksa Pharmaceuticals, Ltd. | COM CL A | G5269C101 | 76,500 | 3,000,000 | SH | | SOLE | | 3,000,000 | 0 | 0 |
| Krystal Biotech, Inc. | COM | 501147102 | 2,016 | 114,674 | SH | | SOLE | | 114,674 | 0 | 0 |
| La Jolla Pharmaceutical Company | COM PAR $.0001 2 | 503459604 | 3,114 | 154,675 | SH | | SOLE | | 154,675 | 0 | 0 |
| Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 250,377 | 1,169,278 | SH | | SOLE | | 1,169,278 | 0 | 0 |
| Menlo Therapeutics Inc. | COM | 586858102 | 6,895 | 700,000 | SH | | SOLE | | 700,000 | 0 | 0 |
| Merus N.V. | COM | N5749R100 | 22,899 | 1,160,014 | SH | | SOLE | | 1,160,014 | 0 | 0 |
| Mirati Therapeutics, Inc. | COM | 60468T105 | 118,384 | 2,513,462 | SH | | SOLE | | 2,513,462 | 0 | 0 |
| Molecular Templates, Inc. | COM | 608550109 | 1,370 | 254,230 | SH | | SOLE | | 254,230 | 0 | 0 |
| Momenta Pharmaceuticals, Inc. | COM | 60877T100 | 8,114 | 308,500 | SH | | SOLE | | 308,500 | 0 | 0 |
| MyoKardia, Inc. | COM | 62857M105 | 23,290 | 357,215 | SH | | SOLE | | 357,215 | 0 | 0 |
| Neurocrine Biosciences, Inc. | COM | 64125C109 | 116,142 | 944,624 | SH | | SOLE | | 944,624 | 0 | 0 |
| Novavax, Inc. | COM | 670002104 | 8,870 | 4,718,318 | SH | | SOLE | | 4,718,318 | 0 | 0 |
| Ovid Therapeutics Inc. | COM | 690469101 | 1,260 | 222,139 | SH | | SOLE | | 222,139 | 0 | 0 |
| Principia Biopharma Inc. | COM | 74257L108 | 52,240 | 1,787,807 | SH | | SOLE | | 1,787,807 | 0 | 0 |
| Proteon Therapeutics, Inc. | COM | 74371L109 | 582 | 298,591 | SH | | SOLE | | 298,591 | 0 | 0 |
| Ra Pharmaceuticals, Inc. | COM | 74933V108 | 3,219 | 177,952 | SH | | SOLE | | 177,952 | 0 | 0 |
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | 78,998 | 2,708,200 | SH | | SOLE | | 2,708,200 | 0 | 0 |
| Ritter Pharmaceuticals, Inc. | COM | 767836307 | 521 | 279,999 | SH | | SOLE | | 279,999 | 0 | 0 |
| Sage Therapeutics, Inc. | COM | 78667J108 | 80,159 | 567,497 | SH | | SOLE | | 567,497 | 0 | 0 |
| Sangamo Therapeutics, Inc. | COM | 800677106 | 21,762 | 1,283,923 | SH | | SOLE | | 1,283,923 | 0 | 0 |
| Seattle Genetics, Inc. | COM | 812578102 | 3,936,672 | 51,046,060 | SH | | SOLE | | 51,046,060 | 0 | 0 |
| Solid Biosciences Inc. | COM | 83422E105 | 27,736 | 587,884 | SH | | SOLE | | 587,884 | 0 | 0 |
| Spark Therapeutics, Inc. | COM | 84652J103 | 75,504 | 1,384,130 | SH | | SOLE | | 1,384,130 | 0 | 0 |
| Spring Bank Pharmaceuticals, Inc. | COM | 849431101 | 7,388 | 613,144 | SH | | SOLE | | 613,144 | 0 | 0 |
| Sunesis Pharmaceuticals, Inc. | COM PAR | 867328700 | 1,113 | 556,665 | SH | | SOLE | | 556,665 | 0 | 0 |
| Syros Pharmaceuticals, Inc. | COM | 87184Q107 | 6,846 | 574,835 | SH | | SOLE | | 574,835 | 0 | 0 |
| Tricida, Inc. | COM | 89610F101 | 48,880 | 1,600,000 | SH | | SOLE | | 1,600,000 | 0 | 0 |
| Trillium Therapeutics Inc. | COM | 89620X506 | 2,931 | 505,262 | SH | | SOLE | | 505,262 | 0 | 0 |
| uniQure N.V. | SHS | N90064101 | 22,016 | 605,000 | SH | | SOLE | | 605,000 | 0 | 0 |
| Versartis, Inc. | COM | 92529L102 | 3,397 | 2,426,310 | SH | | SOLE | | 2,426,310 | 0 | 0 |
| Viking Therapeutics, Inc. | COM | 92686J106 | 7,404 | 425,000 | SH | | SOLE | | 425,000 | 0 | 0 |
| Xencor, Inc. | COM | 98401F105 | 23,479 | 602,495 | SH | | SOLE | | 602,495 | 0 | 0 |
| Y-mAbs Therapeutics, Inc. | COM | 984241109 | 3,984 | 150,000 | SH | | SOLE | | 150,000 | 0 | 0 |
| Zymeworks Inc. | COM | 98985W102 | 20,584 | 1,311,085 | SH | | SOLE | | 1,311,085 | 0 | 0 |
| BioMarin Pharmaceutical Inc. | NOTE 0.75% 10/15/2018 | 09061GAE1 | 12,599 | 12,228,000 | SH | | SOLE | | 12,228,000 | 0 | 0 |
| BioMarin Pharmaceutical Inc. | NOTE 0.599% 8/1/2024 | 09061GAH4 | 15,818 | 15,000,000 | SH | | SOLE | | 15,000,000 | 0 | 0 |
| Corsicanto II Designated Activity Company | NOTE 3.5% 1/5/2047 | 220485AB2 | 41,748 | 10,000,000 | SH | | SOLE | | 10,000,000 | 0 | 0 |
| Neurocrine Biosciences, Inc. | NOTE 2.25% 5/15/2024 | 64125CAD1 | 17,062 | 10,000,000 | SH | | SOLE | | 10,000,000 | 0 | 0 |
