| COLUMN 1 | COLUMN 2 | COLUMN 3 | COLUMN 4 | COLUMN 5 | COLUMN 6 | COLUMN 7 | COLUMN 8 |
| | | VALUE | SHRS OR | SH/ | PUT/ | INVESTMENT | OTHER | VOTING AUTHORITY |
| NAME OF ISSUER | TITLE OF CLASS | CUSIP | (x$1000) | PRN AMT | PRN | CALL | DISCRETION | MANAGER | SOLE | SHARED | NONE |
| Abeona Therapeutics Inc. | COM | 00289Y107 | 15,017 | 2,103,164 | SH | | SOLE | | 2,103,164 | 0 | 0 |
| ACADIA Pharmaceuticals Inc. | COM | 004225108 | 642,173 | 39,713,842 | SH | | SOLE | | 39,713,842 | 0 | 0 |
| Acceleron Pharma Inc. | COM | 00434H108 | 3,654 | 83,900 | SH | | SOLE | | 83,900 | 0 | 0 |
| Achillion Pharmaceuticals, Inc. | COM | 00448Q201 | 1,742 | 1,095,359 | SH | | SOLE | | 1,095,359 | 0 | 0 |
| Adamas Pharmaceuticals, Inc. | COM | 00548A106 | 1,474 | 172,630 | SH | | SOLE | | 172,630 | 0 | 0 |
| Aeglea BioTherapeutics, Inc. | COM | 00773J103 | 12,835 | 1,713,604 | SH | | SOLE | | 1,713,604 | 0 | 0 |
| Aevi Genomic Medicine, Inc. | COM | 00835P105 | 2,765 | 3,950,419 | SH | | SOLE | | 3,950,419 | 0 | 0 |
| Affimed N.V. | COM | N01045108 | 622 | 200,000 | SH | | SOLE | | 200,000 | 0 | 0 |
| Aimmune Therapeutics, Inc. | COM | 00900T107 | 16,120 | 673,908 | SH | | SOLE | | 673,908 | 0 | 0 |
| Albireo Pharma, Inc. | COM | 01345P106 | 6,133 | 250,000 | SH | | SOLE | | 250,000 | 0 | 0 |
| Alexion Pharmaceuticals, Inc. | COM | 015351109 | 833,002 | 8,555,894 | SH | | SOLE | | 8,555,894 | 0 | 0 |
| Alkermes plc | SHS | G01767105 | 1,977 | 67,000 | SH | | SOLE | | 67,000 | 0 | 0 |
| Amarin Corporation plc | SPONSORED ADR | 023111206 | 579,688 | 42,592,824 | SH | | SOLE | | 42,592,824 | 0 | 0 |
| AnaptysBio, Inc. | COM | 032724106 | 7,214 | 113,086 | SH | | SOLE | | 113,086 | 0 | 0 |
| Apellis Pharmaceuticals, Inc. | COM | 03753U106 | 2,586 | 196,078 | SH | | SOLE | | 196,078 | 0 | 0 |
| Aquestive Therapeutics, Inc. | COM | 03843E104 | 627 | 99,600 | SH | | SOLE | | 99,600 | 0 | 0 |
| Aquinox Pharmaceuticals, Inc. | COM | 03842B101 | 23,618 | 10,934,154 | SH | | SOLE | | 10,934,154 | 0 | 0 |
| Aravive, Inc. | COM | 03890D108 | 1,423 | 404,384 | SH | | SOLE | | 404,384 | 0 | 0 |
| Arcus Biosciences, Inc. | COM | 03969F109 | 1,309 | 121,534 | SH | | SOLE | | 121,534 | 0 | 0 |
| argenx SE | SPONSORED ADR | 04016X101 | 97,949 | 1,019,557 | SH | | SOLE | | 1,019,557 | 0 | 0 |
| Array BioPharma Inc. | COM | 04269X105 | 71,844 | 5,041,696 | SH | | SOLE | | 5,041,696 | 0 | 0 |
| Ascendis Pharma A/S | SPONSORED ADR | 04351P101 | 177,760 | 2,837,352 | SH | | SOLE | | 2,837,352 | 0 | 0 |
| Assembly Biosciences, Inc. | COM | 045396108 | 3,361 | 148,587 | SH | | SOLE | | 148,587 | 0 | 0 |
| Audentes Therapeutics, Inc. | COM | 05070R104 | 19,411 | 910,463 | SH | | SOLE | | 910,463 | 0 | 0 |
| Autolus Therapeutics plc | SPON ADS | 05280R100 | 5,148 | 156,773 | SH | | SOLE | | 156,773 | 0 | 0 |
| BeiGene, Ltd. | SPONSORED ADR | 07725L102 | 1,677,485 | 11,959,824 | SH | | SOLE | | 11,959,824 | 0 | 0 |
| Bellicum Pharmaceuticals, Inc. | COM | 079481107 | 7,819 | 2,677,818 | SH | | SOLE | | 2,677,818 | 0 | 0 |
| BioCryst Pharmaceuticals, Inc. | COM | 09058V103 | 121,882 | 15,103,081 | SH | | SOLE | | 15,103,081 | 0 | 0 |
| BioMarin Pharmaceutical Inc. | COM | 09061G101 | 646,228 | 7,589,294 | SH | | SOLE | | 7,589,294 | 0 | 0 |
| bluebird bio, Inc. | COM | 09609G100 | 3,968 | 40,000 | SH | | SOLE | | 40,000 | 0 | 0 |
| Catalyst Pharmaceuticals, Inc. | COM | 14888U101 | 5,568 | 2,900,000 | SH | | SOLE | | 2,900,000 | 0 | 0 |
| Cerus Corporation | COM | 157085101 | 54,502 | 10,749,937 | SH | | SOLE | | 10,749,937 | 0 | 0 |
| ChemoCentryx, Inc. | COM | 16383L106 | 2,259 | 207,029 | SH | | SOLE | | 207,029 | 0 | 0 |
| Clementia Pharmaceuticals Inc. | COM | 185575107 | 43,799 | 3,724,445 | SH | | SOLE | | 3,724,445 | 0 | 0 |
| ContraFect Corporation | COM | 212326102 | 10,944 | 7,153,076 | SH | | SOLE | | 7,153,076 | 0 | 0 |
| Constellation Pharmaceuticals, Inc. | COM | 210373106 | 535 | 133,333 | SH | | SOLE | | 133,333 | 0 | 0 |
| Crinetics Pharmaceuticals, Inc. | COM | 22663K107 | 3,936 | 131,250 | SH | | SOLE | | 131,250 | 0 | 0 |
| CymaBay Therapeutics, Inc. | COM | 23257D103 | 38,702 | 4,917,700 | SH | | SOLE | | 4,917,700 | 0 | 0 |
| DBV Technologies S.A. | SPONSORED ADR | 23306J101 | 35,371 | 5,509,560 | SH | | SOLE | | 5,509,560 | 0 | 0 |
| Dynavax Technologies Corporation | COM | 268158201 | 686 | 75,000 | SH | | SOLE | | 75,000 | 0 | 0 |
| Foamix Pharmaceuticals Ltd. | SHS | M46135105 | 1,788 | 498,189 | SH | | SOLE | | 498,189 | 0 | 0 |
| Forty Seven, Inc. | COM | 34983P104 | 3,930 | 250,000 | SH | | SOLE | | 250,000 | 0 | 0 |
| Fulgent Genetics, Inc. | COM | 359664109 | 396 | 125,000 | SH | | SOLE | | 125,000 | 0 | 0 |
| G1 Therapeutics, Inc. | COM | 3621LQ109 | 2,437 | 127,236 | SH | | SOLE | | 127,236 | 0 | 0 |
| Galapagos NV | SPONSORED ADR | 36315X101 | 2,300 | 25,072 | SH | | SOLE | | 25,072 | 0 | 0 |
| Galmed Pharmaceuticals Ltd. | SHS | M47238106 | 1,473 | 215,594 | SH | | SOLE | | 215,594 | 0 | 0 |
| Genomic Health, Inc. | COM | 37244C101 | 756,432 | 11,744,010 | SH | | SOLE | | 11,744,010 | 0 | 0 |
| GW Pharmaceuticals plc | ADS | 36197T103 | 41,717 | 428,345 | SH | | SOLE | | 428,345 | 0 | 0 |
| Halozyme Therapeutics, Inc. | COM | 40637H109 | 4,389 | 299,969 | SH | | SOLE | | 299,969 | 0 | 0 |
| Heron Therapeutics, Inc. | COM | 427746102 | 130,170 | 5,018,104 | SH | | SOLE | | 5,018,104 | 0 | 0 |
| Idera Pharmaceuticals, Inc. | COM PAR | 45168K405 | 13,396 | 4,836,237 | SH | | SOLE | | 4,836,237 | 0 | 0 |
| Incyte Corporation | COM | 45337C102 | 2,178,060 | 34,251,607 | SH | | SOLE | | 34,251,607 | 0 | 0 |
| Infinity Pharmaceuticals, Inc. | COM | 45665G303 | 685 | 580,400 | SH | | SOLE | | 580,400 | 0 | 0 |
| InflaRx N.V. | COM | N44821101 | 6,510 | 178,987 | SH | | SOLE | | 178,987 | 0 | 0 |
| Insmed Incorporated | COM PAR $.01 | 457669307 | 24,298 | 1,851,982 | SH | | SOLE | | 1,851,982 | 0 | 0 |
| Intellia Therapeutics, Inc. | COM | 45826J105 | 1,755 | 128,538 | SH | | SOLE | | 128,538 | 0 | 0 |
| Invitae Corporation | COM | 46185L103 | 43,161 | 3,902,421 | SH | | SOLE | | 3,902,421 | 0 | 0 |
| Kiniksa Pharmaceuticals, Ltd. | COM CL A | G5269C101 | 84,270 | 3,000,000 | SH | | SOLE | | 3,000,000 | 0 | 0 |
| Kodiak Sciences Inc. | COM | 50015M109 | 64,930 | 9,145,115 | SH | | SOLE | | 9,145,115 | 0 | 0 |
| Krystal Biotech, Inc. | COM | 501147102 | 16,306 | 784,674 | SH | | SOLE | | 784,674 | 0 | 0 |
| La Jolla Pharmaceutical Company | COM PAR $.0001 2 | 503459604 | 1,459 | 154,675 | SH | | SOLE | | 154,675 | 0 | 0 |
| Madrigal Pharmaceuticals, Inc. | COM | 558868105 | 131,801 | 1,169,278 | SH | | SOLE | | 1,169,278 | 0 | 0 |
| Marker Therapeutics, Inc. | COM | 57055L107 | 8,325 | 1,500,000 | SH | | SOLE | | 1,500,000 | 0 | 0 |
| Menlo Therapeutics Inc. | COM | 586858102 | 2,884 | 700,000 | SH | | SOLE | | 700,000 | 0 | 0 |
| Merus N.V. | COM | N5749R100 | 16,240 | 1,160,014 | SH | | SOLE | | 1,160,014 | 0 | 0 |
| Mirati Therapeutics, Inc. | COM | 60468T105 | 106,621 | 2,513,462 | SH | | SOLE | | 2,513,462 | 0 | 0 |
| Molecular Templates, Inc. | COM | 608550109 | 1,027 | 254,230 | SH | | SOLE | | 254,230 | 0 | 0 |
| MyoKardia, Inc. | COM | 62857M105 | 15,403 | 315,243 | SH | | SOLE | | 315,243 | 0 | 0 |
| Neurocrine Biosciences, Inc. | COM | 64125C109 | 52,155 | 730,355 | SH | | SOLE | | 730,355 | 0 | 0 |
| Novavax, Inc. | COM | 670002104 | 8,682 | 4,718,318 | SH | | SOLE | | 4,718,318 | 0 | 0 |
| Orchard Therapeutics plc | ADS | 68570P101 | 1,966 | 125,000 | SH | | SOLE | | 125,000 | 0 | 0 |
| Principia Biopharma Inc. | COM | 74257L108 | 48,968 | 1,787,807 | SH | | SOLE | | 1,787,807 | 0 | 0 |
| Proteon Therapeutics, Inc. | COM | 74371L109 | 678 | 298,591 | SH | | SOLE | | 298,591 | 0 | 0 |
| Ra Pharmaceuticals, Inc. | COM | 74933V108 | 14,981 | 823,113 | SH | | SOLE | | 823,113 | 0 | 0 |
| Rhythm Pharmaceuticals, Inc. | COM | 76243J105 | 72,796 | 2,708,200 | SH | | SOLE | | 2,708,200 | 0 | 0 |
| Ritter Pharmaceuticals, Inc. | COM | 767836307 | 168 | 279,999 | SH | | SOLE | | 279,999 | 0 | 0 |
| Sangamo Therapeutics, Inc. | COM | 800677106 | 11,478 | 999,823 | SH | | SOLE | | 999,823 | 0 | 0 |
| Seattle Genetics, Inc. | COM | 812578102 | 2,892,270 | 51,046,060 | SH | | SOLE | | 51,046,060 | 0 | 0 |
| Sierra Oncology, Inc. | COM | 82640U107 | 2,640 | 2,000,000 | SH | | SOLE | | 2,000,000 | 0 | 0 |
| Solid Biosciences Inc. | COM | 83422E105 | 15,755 | 587,884 | SH | | SOLE | | 587,884 | 0 | 0 |
| Spark Therapeutics, Inc. | COM | 84652J103 | 54,175 | 1,384,130 | SH | | SOLE | | 1,384,130 | 0 | 0 |
| Spring Bank Pharmaceuticals, Inc. | COM | 849431101 | 6,371 | 613,144 | SH | | SOLE | | 613,144 | 0 | 0 |
| Sunesis Pharmaceuticals, Inc. | COM PAR | 867328700 | 231 | 556,665 | SH | | SOLE | | 556,665 | 0 | 0 |
| Syros Pharmaceuticals, Inc. | COM | 87184Q107 | 3,202 | 574,835 | SH | | SOLE | | 574,835 | 0 | 0 |
| Tricida, Inc. | COM | 89610F101 | 37,728 | 1,600,000 | SH | | SOLE | | 1,600,000 | 0 | 0 |
| Trillium Therapeutics Inc. | COM | 89620X506 | 864 | 505,262 | SH | | SOLE | | 505,262 | 0 | 0 |
| uniQure N.V. | SHS | N90064101 | 17,436 | 605,000 | SH | | SOLE | | 605,000 | 0 | 0 |
| Viking Therapeutics, Inc. | COM | 92686J106 | 3,251 | 425,000 | SH | | SOLE | | 425,000 | 0 | 0 |
| Xencor, Inc. | COM | 98401F105 | 15,917 | 440,186 | SH | | SOLE | | 440,186 | 0 | 0 |
| Y-mAbs Therapeutics, Inc. | COM | 984241109 | 2,091 | 102,800 | SH | | SOLE | | 102,800 | 0 | 0 |
| Zymeworks Inc. | COM | 98985W102 | 25,080 | 1,708,472 | SH | | SOLE | | 1,708,472 | 0 | 0 |
| BioMarin Pharmaceutical Inc. | NOTE 0.599% 8/1/2024 | 09061GAH4 | 14,911 | 15,000,000 | PRN | | SOLE | | 15,000,000 | 0 | 0 |
| Neurocrine Biosciences, Inc. | NOTE 2.25% 5/15/2024 | 64125CAD1 | 63,434 | 53,270,000 | PRN | | SOLE | | 53,270,000 | 0 | 0 |
