Segment Information | SEGMENT INFORMATION During the three months ended September 30, 2018 and 2017, two customers within the U.S. segment that are large pharmaceutical distributors accounted for 74% and 73% , respectively, of the Company’s consolidated revenues. During the nine months ended September 30, 2018 and 2017, these same two customers accounted for 76% and 73% , respectively, of the Company’s consolidated revenues. These same two customers within the U.S. segment accounted for approximately 80% and 81% of the Company’s consolidated accounts receivable at September 30, 2018 and at December 31, 2017, respectively. The Company’s chief operating decision maker is the Chief Executive Officer (CEO). While the CEO is apprised of a variety of financial metrics and information, the business is principally managed and organized based upon geographic and regulatory environment. Each segment is separately managed and is evaluated primarily upon segment loss from operations. Non-cash items including stock-based compensation expense and depreciation and amortization are categorized as Other within the table below. The following table presents a summary of the Company’s reporting segments for the three months ended September 30, 2018 and 2017: Three Months Ended Three Months Ended U.S. International Other Consolidated U.S. International Other Consolidated (In thousands) NET REVENUE $ 8,492 $ 2,645 $ — $ 11,137 $ 7,143 $ 2,641 $ — $ 9,784 COST OF GOODS SOLD, EXCLUDING DEPRECIATION AND AMORTIZATION (715 ) (250 ) — (965 ) (720 ) (319 ) — (1,039 ) GROSS PROFIT 7,777 2,395 — 10,172 6,423 2,322 — 8,745 RESEARCH, DEVELOPMENT AND MEDICAL AFFAIRS EXPENSES 1,684 904 211 2,799 1,360 984 3,076 5,420 GENERAL AND ADMINISTRATIVE EXPENSES 2,050 786 610 3,446 1,879 673 768 3,320 SALES AND MARKETING EXPENSES 3,913 1,356 211 5,480 4,141 1,551 310 6,002 DEPRECIATION AND AMORTIZATION — — 642 642 — — 679 679 RECOVERABLE COLLABORATION COSTS — — — — (2,851 ) (2,851 ) OPERATING EXPENSES 7,647 3,046 1,674 12,367 7,380 3,208 1,982 12,570 SEGMENT GAIN (LOSS) FROM OPERATIONS 130 (651 ) (1,674 ) (2,195 ) (957 ) (886 ) (1,982 ) (3,825 ) OTHER INCOME AND EXPENSES, NET — — (1,227 ) (1,227 ) — — (1,437 ) (1,437 ) NET LOSS BEFORE TAXES $ (3,422 ) $ (5,262 ) The following table presents a summary of the Company’s reporting segments for the nine months ended September 30, 2018 and 2017: Nine Months Ended Nine Months Ended U.S. International Other Consolidated U.S. International Other Consolidated (In thousands) NET REVENUE $ 23,468 $ 8,388 $ — $ 31,856 $ 19,643 $ 7,127 $ — $ 26,770 COST OF GOODS SOLD, EXCLUDING DEPRECIATION AND AMORTIZATION (2,456 ) (898 ) — (3,354 ) (1,671 ) (724 ) — (2,395 ) GROSS PROFIT 21,012 7,490 — 28,502 17,972 6,403 — 24,375 RESEARCH, DEVELOPMENT AND MEDICAL AFFAIRS EXPENSES 4,926 2,808 664 8,398 4,016 2,243 3,509 9,768 GENERAL AND ADMINISTRATIVE EXPENSES 6,209 2,416 1,905 10,530 5,410 2,068 2,118 9,596 SALES AND MARKETING EXPENSES 12,427 4,127 821 17,375 11,707 3,930 927 16,564 DEPRECIATION AND AMORTIZATION — — 1,941 1,941 — — 2,012 2,012 RECOVERABLE COLLABORATION COSTS — — — — — — (2,851 ) (2,851 ) OPERATING EXPENSES 23,562 9,351 5,331 38,244 21,133 8,241 5,715 35,089 SEGMENT LOSS FROM OPERATIONS (2,550 ) (1,861 ) (5,331 ) (9,742 ) (3,161 ) (1,838 ) (5,715 ) (10,714 ) OTHER INCOME AND EXPENSES, NET — — (5,288 ) (5,288 ) — — (3,970 ) (3,970 ) NET LOSS BEFORE TAXES $ (15,030 ) $ (14,684 ) |