Janus Henderson (JHG) 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
21VIANET GROUP INC	SPONSORED ADS A	90138A103	3,420	147,699	SH		DFND	4	0	147,699	0
3M CO	COM	88579Y101	96,449	602,149	SH		DFND	2 4 9	0	211,955	390,194
89BIO INC	COM	282559103	1,556	60,650	SH		DFND	10	0	60,650	0
ABB LTD	SPONSORED ADR	000375204	557	21,905	SH		DFND	4 10	0	21,905	0
ABBOTT LABS	COM	002824100	1,154,355	10,607,026	SH		DFND	4 9 10	0	10,348,839	258,187
ABBVIE INC	COM	00287Y109	1,486,298	16,968,979	SH		DFND	4 9 10	0	14,032,211	2,936,768
ABIOMED INC	COM	003654100	38,387	138,560	SH		DFND	4 9 10	0	45,846	92,714
ACADIA PHARMACEUTICALS INC	COM	004225108	235,378	5,706,104	SH		DFND	9 10	0	5,374,091	332,013
ACCELERON PHARMA INC	COM	00434H108	200,745	1,783,939	SH		DFND	9 10	0	1,721,528	62,411
ACCENTURE PLC IRELAND	SHS CLASS A	G1151C101	1,119,409	4,953,409	SH		DFND	4 9 10	0	4,104,998	848,411
ACI WORLDWIDE INC	COM	004498101	76,099	2,912,336	SH		DFND	4 10	0	2,809,811	102,525
ACM RESEARCH INC	COM CL A	00108J109	1,257	18,195	SH		DFND	10	0	18,195	0
ACTIVISION BLIZZARD INC	COM	00507V109	201,865	2,493,745	SH		DFND	4 9 10	0	1,827,069	666,676
ACUITY BRANDS INC	COM	00508Y102	472	4,608	SH		DFND	9 10	0	4,488	120
ADDUS HOMECARE CORP	COM	006739106	323	3,414	SH		DFND	10	0	3,414	0
ADOBE SYSTEMS INCORPORATED	COM	00724F101	3,312,792	6,755,875	SH		DFND	4 9 10	0	6,217,117	538,758
ADT INC DEL	COM	00090Q103	6,463	790,572	SH		DFND	4 9	0	789,473	1,099
ADVANCE AUTO PARTS INC	COM	00751Y106	2,754	17,938	SH		DFND	4 9	0	17,938	0
ADVANCED MICRO DEVICES INC	COM	007903107	229,377	2,797,737	SH		DFND	4 9	0	1,362,798	1,434,939
AERCAP HOLDINGS NV	SHS	N00985106	1,057	41,963	SH		DFND	4 9	0	18,572	23,391
AEROJET ROCKETDYNE HLDGS INC	COM	007800105	352	8,821	SH		DFND	10	0	8,821	0
AES CORP	COM	00130H105	30,047	1,659,157	SH		DFND	4 9	0	1,535,247	123,910
AFLAC INC	COM	001055102	6,471	178,023	SH		DFND	4 9 10	0	178,023	0
AFYA LTD	CL A COM	G01125106	13,055	478,833	SH		DFND	4	0	478,833	0
AGILENT TECHNOLOGIES INC	COM	00846U101	42,142	417,518	SH		DFND	2 4 9 10	0	404,674	12,844
AGNC INVT CORP	COM	00123Q104	2,449	176,056	SH		DFND	4 9	0	176,056	0
AGNICO EAGLE MINES LTD	COM	008474108	13,068	164,514	SH		DFND	4 9	0	93,139	71,375
AIR PRODS & CHEMS INC	COM	009158106	587,493	1,972,361	SH		DFND	4 9 10 11	0	1,461,889	510,472
AKAMAI TECHNOLOGIES INC	COM	00971T101	10,885	98,475	SH		DFND	4 9	0	69,715	28,760
AKERO THERAPEUTICS INC	COM	00973Y108	108,856	3,535,455	SH		DFND	10	0	3,423,625	111,830
ALAMO GROUP INC	COM	011311107	19,210	177,819	SH		DFND	10	0	169,776	8,043
ALARM COM HLDGS INC	COM	011642105	80,917	1,464,562	SH		DFND	10	0	1,413,015	51,547
ALBANY INTL CORP	CL A	012348108	266	5,365	SH		DFND	4 10	0	5,365	0
ALBEMARLE CORP	COM	012653101	5,185	58,082	SH		DFND	4 9 11	0	57,208	874
ALCON AG	ORD SHS	H01301128	10,157	178,448	SH		DFND	4 9 10	0	86,193	92,255
ALEXANDRIA REAL ESTATE EQ IN	COM	015271109	64,145	401,142	SH		DFND	4 9 10 12	0	378,780	22,362
ALEXION PHARMACEUTICALS INC	COM	015351109	177,060	1,547,353	SH		DFND	4 9 10	0	1,410,972	136,381
ALGONQUIN PWR UTILS CORP	COM	015857105	177	12,257	SH		DFND	4 9	0	12,257	0
ALIBABA GROUP HLDG LTD	SPONSORED ADS	01609W102	407,945	1,388,116	SH		DFND	4 9 10 12	0	1,297,783	90,333
ALIGN TECHNOLOGY INC	COM	016255101	431,017	1,316,661	SH		DFND	4 9 10	0	1,219,116	97,545
ALLEGHANY CORP DEL	COM	017175100	3,426	6,582	SH		DFND	4 9	0	6,581	1
ALLEGIANT TRAVEL CO	COM	01748X102	522	4,356	SH		DFND	10	0	4,356	0
ALLEGION PLC	ORD SHS	G0176J109	4,366	44,163	SH		DFND	4 9	0	44,163	0
ALLIANT ENERGY CORP	COM	018802108	304,336	5,892,251	SH		DFND	2 4 9 10	0	5,639,248	253,003
ALLISON TRANSMISSION HLDGS I	COM	01973R101	446	12,701	SH		DFND	10	0	12,701	0
ALLSTATE CORP	COM	020002101	30,665	325,777	SH		DFND	4 9	0	272,856	52,921
ALLY FINL INC	COM	02005N100	12,349	492,585	SH		DFND	4 9	0	189,002	303,583
ALNYLAM PHARMACEUTICALS INC	COM	02043Q107	23,669	162,569	SH		DFND	4 9 10	0	147,877	14,692
ALPHABET INC	CAP STK CL A	02079K305	647,540	441,934	SH		DFND	2 4 9 10	0	408,684	33,250
ALPHABET INC	CAP STK CL C	02079K107	3,293,938	2,241,519	SH		DFND	4 9 10	0	2,077,428	164,091
ALTAIR ENGR INC	COM CL A	021369103	99,092	2,360,453	SH		DFND	10	0	2,280,486	79,967
ALTERYX INC	COM CL A	02156B103	2,014	17,737	SH		DFND	10	0	17,737	0
ALTICE USA INC	CL A	02156K103	4,215	162,127	SH		DFND	4 9	0	162,127	0
ALTRIA GROUP INC	COM	02209S103	159,646	4,131,701	SH		DFND	4 9 10	0	4,010,141	121,560
ALX ONCOLOGY HLDGS INC	COM	00166B105	16,221	429,802	SH		DFND	10	0	405,504	24,298
AMAZON COM INC	COM	023135106	7,203,374	2,287,791	SH		DFND	4 9 10	0	2,068,613	219,178
AMAZON COM INC	COM	023135106	54	300	SH	Call	DFND	10	0	3	0
AMBARELLA INC	SHS	G037AX101	65,616	1,257,364	SH		DFND	4	0	1,257,364	0
AMCOR PLC	ORD	G0250X107	22,370	2,024,609	SH		DFND	4 9	0	1,129,426	895,183
AMDOCS LTD	SHS	G02602103	390,989	6,810,470	SH		DFND	4 9 10	0	6,624,874	185,596
AMEDISYS INC	COM	023436108	4,439	18,774	SH		DFND	9 10	0	18,272	502
AMERCO	COM	023586100	23,518	66,066	SH		DFND	4 9 10	0	58,099	7,967
AMEREN CORP	COM	023608102	15,310	193,601	SH		DFND	4 9	0	193,601	0
AMERICAN AIRLS GROUP INC	COM	02376R102	117	362,500	SH	Call	DFND	10	0	3,625	0
AMERICAN AIRLS GROUP INC	COM	02376R102	118	365,700	SH	Call	DFND	10	0	3,657	0
AMERICAN AIRLS GROUP INC	COM	02376R102	1	3,200	SH	Call	DFND	10	0	32	0
AMERICAN AIRLS GROUP INC	COM	02376R102	697	56,735	SH		DFND	4 9	0	56,735	0
AMERICAN ELEC PWR CO INC	COM	025537101	146,022	1,786,632	SH		DFND	4 9 10	0	1,600,062	186,570
AMERICAN ELEC PWR CO INC	UNIT 99/99/9999	02557T307	1,957	40,000	SH		DFND	10	0	40,000	0
AMERICAN EXPRESS CO	COM	025816109	444,180	4,430,821	SH		DFND	4 9 10	0	4,276,125	154,696
AMERICAN FINL GROUP INC OHIO	COM	025932104	873	13,042	SH		DFND	4 9	0	13,042	0
AMERICAN HOMES 4 RENT	CL A	02665T306	38,241	1,342,951	SH		DFND	4 10 12	0	1,305,240	37,711
AMERICAN INTL GROUP INC	COM NEW	026874784	24,522	890,770	SH		DFND	2 4 9	0	708,957	181,813
AMERICAN TOWER CORP NEW	COM	03027X100	944,933	3,909,255	SH		DFND	4 9 10 12	0	3,534,919	374,336
AMERICAN VANGUARD CORP	COM	030371108	19,653	1,495,670	SH		DFND	2	0	1,495,670	0
AMERICAN WELL CORP	CL A	03044L105	1,378	46,508	SH		DFND	10	0	34,648	11,860
AMERICAN WOODMARK CORPORATIO	COM	030506109	358	4,557	SH		DFND	10	0	4,557	0
AMERICAN WTR WKS CO INC NEW	COM	030420103	47,015	324,544	SH		DFND	4 9	0	305,557	18,987
AMERICOLD RLTY TR	COM	03064D108	91,642	2,563,649	SH		DFND	2 4 9 10 12	0	2,534,889	28,760
AMERIPRISE FINL INC	COM	03076C106	7,573	49,143	SH		DFND	4 9	0	38,278	10,865
AMERISOURCEBERGEN CORP	COM	03073E105	35,132	362,484	SH		DFND	4 9 10	0	195,945	166,539
AMETEK INC	COM	031100100	55,133	554,662	SH		DFND	2 4 9	0	554,662	0
AMGEN INC	COM	031162100	235,699	927,404	SH		DFND	4 9 10	0	384,953	542,451
AMICUS THERAPEUTICS INC	COM	03152W109	199,181	14,106,259	SH		DFND	10	0	13,620,865	485,394
AMN HEALTHCARE SVCS INC	COM	001744101	2,514	43,009	SH		DFND	4 10	0	43,009	0
AMPHENOL CORP NEW	CL A	032095101	100,155	925,411	SH		DFND	4 9	0	925,411	0
ANALOG DEVICES INC	COM	032654105	209,186	1,792,311	SH		DFND	2 4 9	0	1,696,457	95,854
ANNALY CAPITAL MANAGEMENT IN	COM	035710409	3,441	483,147	SH		DFND	4 9	0	483,147	0
ANNEXON INC	COM	03589W102	49,446	1,727,448	SH		DFND	10	0	1,727,448	0
ANSYS INC	COM	03662Q105	24,968	76,306	SH		DFND	4 9	0	69,112	7,194
ANTHEM INC	COM	036752103	191,919	714,583	SH		DFND	4 9 10	0	538,378	176,205
ANWORTH MTG ASSET CORP	COM	037347101	155	94,219	SH		DFND	2	0	94,219	0
AON PLC	SHS CL A	G0403H108	945,239	4,582,125	SH		DFND	4 9 10	0	4,368,786	213,339
APACHE CORP	COM	037411105	11,068	1,168,705	SH		DFND	9	0	1,088,273	80,432
APOLLO GLOBAL MGMT INC	COM CL A	03768E105	212,746	4,754,108	SH		DFND	4 9 10	0	4,052,630	701,478
APPFOLIO INC	COM CL A	03783C100	2,149	15,157	SH		DFND	10	0	15,157	0
APPLE INC	COM	037833100	52	7,000	SH	Call	DFND	10	0	70	0
APPLE INC	COM	037833100	8,156,963	70,447,468	SH		DFND	4 9 10	0	60,987,483	9,459,985
APPLIED MATLS INC	COM	038222105	19,944	335,609	SH		DFND	4 9	0	335,090	519
APREA THERAPEUTICS INC	COM	03836J102	20,479	851,180	SH		DFND	10	0	821,321	29,859
APTARGROUP INC	COM	038336103	6,120	54,065	SH		DFND	9	0	35,967	18,098
APTIV PLC	SHS	G6095L109	275,587	3,006,043	SH		DFND	2 4 9 10	0	2,943,927	62,116
ARAMARK	COM	03852U106	258,667	9,779,454	SH		DFND	4 9 10	0	9,562,866	216,588
ARCH CAP GROUP LTD	ORD	G0450A105	5,197	177,673	SH		DFND	4 9	0	177,673	0
ARCHER DANIELS MIDLAND CO	COM	039483102	89,760	1,930,774	SH		DFND	4 9 11	0	1,464,834	465,940
ARCTURUS THERAPEUTICS HLDGS	COM	03969T109	20,724	483,078	SH		DFND	10	0	464,369	18,709
ARENA PHARMACEUTICALS INC	COM NEW	040047607	1,677	22,418	SH		DFND	10	0	22,418	0
ARES MANAGEMENT CORPORATION	CL A COM STK	03990B101	2,281	56,437	SH		DFND	4 9	0	31,513	24,924
ARGENX SE	SPONSORED ADR	04016X101	63,784	242,964	SH		DFND	10	0	234,328	8,636
ARGO GROUP INTL HLDGS LTD	COM	G0464B107	41,160	1,195,483	SH		DFND	2	0	1,195,483	0
ARISTA NETWORKS INC	COM	040413106	19,552	94,487	SH		DFND	4 9	0	44,753	49,734
ARROW ELECTRS INC	COM	042735100	1,404	17,850	SH		DFND	4 9	0	17,850	0
ARROWHEAD PHARMACEUTICALS IN	COM	04280A100	49,883	1,158,462	SH		DFND	10	0	1,105,343	53,119
ASCENDIS PHARMA A/S	SPONSORED ADR	04351P101	457,800	2,966,606	SH		DFND	10	0	2,832,928	133,678
ASGN INC	COM	00191U102	895	14,083	SH		DFND	10	0	14,083	0
ASML HOLDING N V	N Y REGISTRY SHS	N07059210	405,158	1,097,204	SH		DFND	10	0	1,046,032	51,172
ASPEN TECHNOLOGY INC	COM	045327103	2,842	22,451	SH		DFND	10	0	22,451	0
ASSETMARK FINL HLDGS INC	COM	04546L106	14,548	669,197	SH		DFND	4 10	0	640,625	28,572
ASSURANT INC	COM	04621X108	34,913	287,798	SH		DFND	4 9	0	80,227	207,571
ASSURED GUARANTY LTD	COM	G0585R106	1,704	79,327	SH		DFND	9	0	52,921	26,406
ASTRAZENECA PLC	SPONSORED ADR	046353108	33,217	606,158	SH		DFND	10	0	606,158	0
AT&T INC	COM	00206R102	65,203	2,288,132	SH		DFND	4 9	0	1,746,662	541,470
ATHENE HOLDING LTD	CL A	G0684D107	839	24,619	SH		DFND	4 9 10	0	23,071	1,548
ATHIRA PHARMA INC	COM	04746L104	18,053	1,003,198	SH		DFND	10	0	1,003,198	0
ATKORE INTL GROUP INC	COM	047649108	288	12,677	SH		DFND	10	0	12,677	0
ATLANTIC UN BANKSHARES CORP	COM	04911A107	60,155	2,814,947	SH		DFND	2	0	2,814,947	0
ATLASSIAN CORP PLC	CL A	G06242104	654,809	3,602,064	SH		DFND	4 9 10	0	3,333,200	268,864
ATMOS ENERGY CORP	COM	049560105	16,642	174,097	SH		DFND	4 9	0	82,426	91,671
AUTODESK INC	COM	052769106	530,640	2,297,293	SH		DFND	4 9 10	0	1,959,928	337,365
AUTOHOME INC	SP ADR RP CL A	05278C107	501	5,220	SH		DFND	9	0	5,220	0
AUTOLIV INC	COM	052800109	1,713	23,506	SH		DFND	4 9	0	23,506	0
AUTOMATIC DATA PROCESSING IN	COM	053015103	151,193	1,083,901	SH		DFND	4 9 10	0	471,425	612,476
AUTOZONE INC	COM	053332102	30,112	25,569	SH		DFND	4 9	0	25,569	0
AVALARA INC	COM	05338G106	517,192	4,061,600	SH		DFND	4 9 10	0	3,740,588	321,012
AVALONBAY CMNTYS INC	COM	053484101	5,725	38,340	SH		DFND	4 9	0	38,340	0
AVANGRID INC	COM	05351W103	883	17,500	SH		DFND	4 10	0	17,500	0
AVANTOR INC	COM	05352A100	934	41,572	SH		DFND	4 9	0	41,572	0
AVERY DENNISON CORP	COM	053611109	46,316	362,299	SH		DFND	4 9 10	0	302,964	59,335
AVIDITY BIOSCIENCES INC	COM	05370A108	5,080	180,446	SH		DFND	10	0	159,938	20,508
AVNET INC	COM	053807103	54,168	2,096,275	SH		DFND	2	0	2,096,275	0
AVROBIO INC	COM	05455M100	834	63,937	SH		DFND	10	0	63,937	0
AXALTA COATING SYS LTD	COM	G0750C108	33,258	1,500,152	SH		DFND	2 4 9	0	1,497,066	3,086
AXIS CAP HLDGS LTD	SHS	G0692U109	40,770	925,747	SH		DFND	2 9	0	869,173	56,574
AXOGEN INC	COM	05463X106	15,077	1,296,412	SH		DFND	10	0	1,237,895	58,517
AXON ENTERPRISE INC	COM	05464C101	132,359	1,459,306	SH		DFND	10	0	1,409,393	49,913
AXSOME THERAPEUTICS INC	COM	05464T104	36,686	514,883	SH		DFND	10	0	496,852	18,031
B2GOLD CORP	COM	11777Q209	3,827	589,127	SH		DFND	4 9 11	0	589,127	0
BAIDU INC	SPON ADR REP A	056752108	591	4,670	SH		DFND	9	0	4,670	0
BAKER HUGHES COMPANY	CL A	05722G100	1,854	139,524	SH		DFND	4 9	0	139,524	0
BALL CORP	COM	058498106	110,546	1,329,985	SH		DFND	4 9 10	0	1,310,594	19,391
BANK HAWAII CORP	COM	062540109	32,874	650,720	SH		DFND	2	0	650,720	0
BANK MONTREAL QUE	COM	063671101	8,459	145,192	SH		DFND	4 9	0	145,192	0
BANK NEW YORK MELLON CORP	COM	064058100	7,505	218,572	SH		DFND	4 9 10	0	214,740	3,832
BANK NOVA SCOTIA B C	COM	064149107	11,438	276,314	SH		DFND	4 9	0	276,314	0
BARRICK GOLD CORP	COM	067901108	118	4,237	SH		DFND	4	0	4,237	0
BARRICK GOLD CORP	COM	067901108	37,647	1,343,280	SH		DFND	4 9	0	1,343,280	0
BAUSCH HEALTH COS INC	COM	071734107	2,508	161,974	SH		DFND	4 9	0	161,974	0
BAXTER INTL INC	COM	071813109	153,786	1,912,292	SH		DFND	4 9 10	0	1,869,043	43,249
BCE INC	COM NEW	05534B760	2,874	69,525	SH		DFND	4 9	0	69,525	0
BCTG ACQUISITION CORP	COM	05492W103	2,311	218,282	SH		DFND	10	0	218,282	0
BECTON DICKINSON & CO	COM	075887109	54,197	232,901	SH		DFND	4 9	0	119,249	113,652
BEIGENE LTD	SPONSORED ADR	07725L102	27,239	95,096	SH		DFND	4 9 10	0	4,167	90,929
BELDEN INC	COM	077454106	9,371	301,134	SH		DFND	10	0	301,134	0
BELLRING BRANDS INC	COM CL A	079823100	18,443	889,243	SH		DFND	10	0	801,453	87,790
BENCHMARK ELECTRS INC	COM	08160H101	13,320	661,048	SH		DFND	2	0	661,048	0
BERKELEY LTS INC	COM	084310101	4,389	57,482	SH		DFND	10	0	24,200	33,282
BERKLEY W R CORP	COM	084423102	406,051	6,640,241	SH		DFND	4 9 10	0	6,441,697	198,544
BERKSHIRE HATHAWAY INC DEL	CL B NEW	084670702	184,956	868,641	SH		DFND	2 4 9 10	0	799,479	69,162
BERKSHIRE HATHAWAY INC DEL	CL A	084670108	11,519	36	SH		DFND	4	0	36	0
BERRY GLOBAL GROUP INC	COM	08579W103	3,271	67,703	SH		DFND	10	0	67,703	0
BEST BUY INC	COM	086516101	287,769	2,585,762	SH		DFND	4 9 10	0	1,148,182	1,437,580
BHP GROUP PLC	SPONSORED ADR	05545E209	9,736	228,253	SH		DFND	4	0	228,253	0
BILL COM HLDGS INC	COM	090043100	4,253	42,395	SH		DFND	10	0	42,395	0
BIO RAD LABS INC	CL A	090572207	22,835	44,302	SH		DFND	4 9	0	24,209	20,093
BIOGEN INC	COM	09062X103	34,016	119,930	SH		DFND	4 9 10	0	76,213	43,717
BIOMARIN PHARMACEUTICAL INC	COM	09061G101	396,730	5,214,710	SH		DFND	4 9 10	0	4,820,843	393,867
BIONTECH SE	SPONSORED ADS	09075V102	56,177	811,468	SH		DFND	10	0	787,084	24,384
BIOSPECIFICS TECHNOLOGIES CO	COM	090931106	15,919	301,321	SH		DFND	2 10	0	301,321	0
BIO-TECHNE CORP	COM	09073M104	183,524	740,821	SH		DFND	9 10	0	708,667	32,154
BIOTELEMETRY INC	COM	090672106	1,986	43,573	SH		DFND	10	0	43,573	0
BK OF AMERICA CORP	COM	060505104	334,269	13,876,724	SH		DFND	4 9 10	0	13,855,823	20,901
BLACK HILLS CORP	COM	092113109	58,082	1,085,847	SH		DFND	2	0	1,085,847	0
BLACK KNIGHT INC	COM	09215C105	1,279	14,698	SH		DFND	4 9	0	14,698	0
BLACKBAUD INC	COM	09227Q100	175,590	3,145,087	SH		DFND	10	0	3,024,340	120,747
BLACKBERRY LTD	COM	09228F103	371	80,973	SH		DFND	4 9	0	80,973	0
BLACKROCK INC	COM	09247X101	19,605	34,791	SH		DFND	4 9	0	34,791	0
BLACKSTONE GROUP INC	COM CL A	09260D107	1,001,911	19,193,787	SH		DFND	4 9 10	0	16,949,521	2,244,266
BMC STK HLDGS INC	COM	05591B109	771	17,995	SH		DFND	10	0	17,995	0
BOEING CO	COM	097023105	20,092	121,574	SH		DFND	4 9	0	121,221	353
BOOKING HOLDINGS INC	COM	09857L108	809,351	473,126	SH		DFND	4 9 10	0	463,155	9,971
BOOZ ALLEN HAMILTON HLDG COR	CL A	099502106	7,768	93,614	SH		DFND	4 9	0	33,448	60,166
BORGWARNER INC	COM	099724106	2,418	62,412	SH		DFND	4 9	0	62,412	0
BOSTON BEER INC	CL A	100557107	7,546	8,542	SH		DFND	9	0	6,667	1,875
BOSTON PROPERTIES INC	COM	101121101	3,083	38,374	SH		DFND	4 9	0	38,374	0
BOSTON SCIENTIFIC CORP	COM	101137107	1,860,903	48,702,542	SH		DFND	4 9 10	0	47,122,973	1,579,569
BOSTON SCIENTIFIC CORP	5.50% CNV PFD A	101137206	1,668	14,971	SH		DFND	10	0	14,971	0
BP PLC	SPONSORED ADR	055622104	3,032	173,668	SH		DFND	2	0	104,135	69,533
BRADY CORP	CL A	104674106	97,282	2,430,835	SH		DFND	10	0	2,322,760	108,075
BRIDGEBIO PHARMA INC	COM	10806X102	63,464	1,691,461	SH		DFND	10	0	1,618,402	73,059
BRIGHAM MINERALS INC	CL A COM	10918L103	909	101,947	SH		DFND	2	0	101,947	0
BRISTOL-MYERS SQUIBB CO	RIGHT 99/99/9999	110122157	54,255	24,112,077	SH		DFND	10	0	23,409,411	702,666
BRISTOL-MYERS SQUIBB CO	COM	110122108	1,431,491	23,744,270	SH		DFND	4 9 10	0	22,288,149	1,456,121
BRITISH AMERN TOB PLC	SPONSORED ADR	110448107	579	16,018	SH		DFND	4 10	0	16,018	0
BROADCOM INC	COM	11135F101	625,819	1,718,342	SH		DFND	4 9	0	1,421,203	297,139
BROADRIDGE FINL SOLUTIONS IN	COM	11133T103	867,313	6,570,549	SH		DFND	4 9 10	0	6,173,101	397,448
BROOKDALE SR LIVING INC	COM	112463104	109	42,815	SH		DFND	10	0	42,815	0
BROOKFIELD ASSET MGMT INC	CL A LTD VT SH	112585104	9,309	282,235	SH		DFND	4 9	0	282,235	0
BROOKFIELD ASSET MGMT INC	CL A LTD VT SH	112585104	1,958	59,243	SH		DFND	4 10	0	59,243	0
BROOKS AUTOMATION INC NEW	COM	114340102	65,193	1,409,278	SH		DFND	10	0	1,346,151	63,127
BROWN & BROWN INC	COM	115236101	21,342	471,446	SH		DFND	4 9	0	438,363	33,083
BROWN FORMAN CORP	CL B	115637209	11,502	152,722	SH		DFND	4 9	0	152,722	0
BRUKER CORP	COM	116794108	112,278	2,824,606	SH		DFND	4 10	0	2,724,136	100,470
BUILDERS FIRSTSOURCE INC	COM	12008R107	1,080	33,094	SH		DFND	4 10	0	33,094	0
BUNGE LIMITED	COM	G16962105	50,599	1,107,215	SH		DFND	4 9	0	322,641	784,574
BURLINGTON STORES INC	COM	122017106	252,554	1,225,453	SH		DFND	4 9 10	0	1,193,912	31,541
BWX TECHNOLOGIES INC	COM	05605H100	147,691	2,622,816	SH		DFND	2 9	0	2,622,622	194
C H ROBINSON WORLDWIDE INC	COM NEW	12541W209	77,842	761,740	SH		DFND	4 9	0	322,947	438,793
CABLE ONE INC	COM	12685J105	87,537	46,429	SH		DFND	4 9 10	0	42,875	3,554
CABOT OIL & GAS CORP	COM	127097103	19,659	1,132,481	SH		DFND	4 9 11	0	715,035	417,446
CADENCE DESIGN SYSTEM INC	COM	127387108	332,457	3,118,007	SH		DFND	4 9 10	0	2,085,458	1,032,549
CAE INC	COM	124765108	43,733	2,998,754	SH		DFND	4 9 10	0	2,859,105	139,649
CAESARS ENTERTAINMENT INC NE	COM	12769G100	194,858	3,475,888	SH		DFND	10	0	3,381,487	94,401
CAL MAINE FOODS INC	COM NEW	128030202	36,647	955,086	SH		DFND	2	0	955,086	0
CALAVO GROWERS INC	COM	128246105	646	9,755	SH		DFND	10	0	9,755	0
CALLAWAY GOLF CO	COM	131193104	313	16,375	SH		DFND	10	0	16,375	0
CAMDEN PPTY TR	SH BEN INT	133131102	77,004	865,412	SH		DFND	2 4 9	0	856,187	9,225
CAMECO CORP	COM	13321L108	1,185	117,603	SH		DFND	4 9 11	0	117,603	0
CAMPBELL SOUP CO	COM	134429109	103,028	2,130,002	SH		DFND	4 9 10	0	766,756	1,363,246
CANADIAN IMP BK COMM	COM	136069101	10,756	144,281	SH		DFND	4 9	0	131,190	13,091
CANADIAN NAT RES LTD	COM	136385101	50,874	3,177,657	SH		DFND	10	0	3,169,383	8,274
CANADIAN NAT RES LTD	COM	136385101	27,601	1,727,571	SH		DFND	4 9 10	0	1,172,213	555,358
CANADIAN NATL RY CO	COM	136375102	17,380	163,751	SH		DFND	4 9	0	163,751	0
CANADIAN PAC RY LTD	COM	13645T100	149	488	SH		DFND	10	0	488	0
CANADIAN PAC RY LTD	COM	13645T100	11,632	38,356	SH		DFND	4 9 10	0	38,356	0
CANOPY GROWTH CORP	COM	138035100	671	46,982	SH		DFND	4 9	0	46,982	0
CANTEL MED CORP	COM	138098108	50,188	1,142,205	SH		DFND	10	0	1,102,906	39,299
CAPITAL ONE FINL CORP	COM	14040H105	7,725	107,505	SH		DFND	4 9	0	107,505	0
CARDIFF ONCOLOGY INC	COM	14147L108	14,368	1,012,818	SH		DFND	10	0	986,610	26,208
CARDINAL HEALTH INC	COM	14149Y108	106,313	2,264,394	SH		DFND	4 9	0	526,310	1,738,084
CARDIOVASCULAR SYS INC DEL	COM	141619106	53,426	1,357,701	SH		DFND	10	0	1,335,896	21,805
CARETRUST REIT INC	COM	14174T107	782	43,973	SH		DFND	10	0	43,973	0
CARGURUS INC	COM CL A	141788109	303	13,988	SH		DFND	10	0	13,988	0
CARLISLE COS INC	COM	142339100	129,278	1,056,450	SH		DFND	2 9 10	0	1,026,206	30,244
CARLYLE GROUP INC	COM	14316J108	5,568	225,714	SH		DFND	4 9	0	107,973	117,741
CARMAX INC	COM	143130102	410,070	4,461,654	SH		DFND	4 9 10	0	4,244,651	217,003
CARNIVAL PLC	ADR	14365C103	7,311	566,060	SH		DFND	4	0	566,060	0
CARRIER GLOBAL CORPORATION	COM	14448C104	23,938	783,845	SH		DFND	4 9 10	0	588,430	195,415
CARTERS INC	COM	146229109	100,671	1,162,750	SH		DFND	2 10	0	1,139,472	23,278
CARVANA CO	CL A	146869102	7,246	32,486	SH		DFND	9	0	18,947	13,539
CASEYS GEN STORES INC	COM	147528103	207,622	1,168,713	SH		DFND	2 9 10	0	1,143,115	25,598
CASS INFORMATION SYS INC	COM	14808P109	26,240	652,089	SH		DFND	2	0	652,089	0
CASTLE BIOSCIENCES INC	COM	14843C105	1,291	25,087	SH		DFND	10	0	25,087	0
CATALENT INC	COM	148806102	1,124,316	13,125,337	SH		DFND	4 9 10	0	12,655,660	469,677
CATERPILLAR INC DEL	COM	149123101	30,860	207,004	SH		DFND	4 9 10	0	207,004	0
CAVCO INDS INC DEL	COM	149568107	288	1,595	SH		DFND	10	0	1,595	0
CBOE GLOBAL MARKETS INC	COM	12503M108	272,411	3,104,757	SH		DFND	4 9 10	0	3,014,127	90,630
CBRE GROUP INC	CL A	12504L109	171,469	3,650,613	SH		DFND	4 9 10	0	3,650,613	0
CDK GLOBAL INC	COM	12508E101	70,288	1,612,467	SH		DFND	2 4 9	0	1,612,467	0
CDW CORP	COM	12514G108	114,627	958,586	SH		DFND	4 9	0	912,434	46,152
CELANESE CORP DEL	COM	150870103	24,526	228,257	SH		DFND	4 9	0	64,100	164,157
CENOVUS ENERGY INC	COM	15135U109	13,029	3,353,042	SH		DFND	4 9	0	305,766	3,047,276
CENTENE CORP DEL	COM	15135B101	275,403	4,721,464	SH		DFND	4 9 10	0	4,554,183	167,281
CENTERPOINT ENERGY INC	COM	15189T107	4,674	241,583	SH		DFND	2 4 9	0	241,583	0
CENTURY CASINOS INC	COM	156492100	12,520	2,284,685	SH		DFND	2	0	2,284,685	0
CERIDIAN HCM HLDG INC	COM	15677J108	418,188	5,059,743	SH		DFND	9 10	0	4,681,917	377,826
CERNER CORP	COM	156782104	42,148	583,061	SH		DFND	2 4 9	0	535,155	47,906
CF INDS HLDGS INC	COM	125269100	2,074	67,538	SH		DFND	4 9	0	67,538	0
CGI INC	CL A SUB VTG	12532H104	5,203	76,962	SH		DFND	4 9	0	76,962	0
CHANNELADVISOR CORP	COM	159179100	33,558	2,319,116	SH		DFND	10	0	2,151,461	167,655
CHARTER COMMUNICATIONS INC N	CL A	16119P108	156,460	250,608	SH		DFND	4 9 10	0	194,084	56,524
CHASE CORP	COM	16150R104	14,518	152,183	SH		DFND	10	0	145,725	6,458
CHECK POINT SOFTWARE TECH LT	ORD	M22465104	58,110	482,884	SH		DFND	2 4 9 10	0	473,125	9,759
CHEGG INC	COM	163092109	54,317	760,369	SH		DFND	4	0	760,369	0
CHEMED CORP NEW	COM	16359R103	91,767	191,042	SH		DFND	4 9 10	0	183,583	7,459
CHENIERE ENERGY INC	COM NEW	16411R208	18,760	405,400	SH		DFND	4 9 10	0	388,120	17,280
CHEVRON CORP NEW	COM	166764100	64,510	896,042	SH		DFND	2 4 9 10	0	632,828	263,214
CHEWY INC	CL A	16679L109	47,973	874,937	SH		DFND	10	0	858,935	16,002
CHIPOTLE MEXICAN GRILL INC	COM	169656105	71,408	57,424	SH		DFND	4 9 10	0	36,111	21,313
CHOICE HOTELS INTL INC	COM	169905106	356	4,141	SH		DFND	10	0	4,141	0
CHUBB LIMITED	COM	H1467J104	22,328	192,298	SH		DFND	2 4 9	0	166,035	26,263
CHURCH & DWIGHT INC	COM	171340102	23,898	255,038	SH		DFND	4 9	0	226,960	28,078
CHURCHILL DOWNS INC	COM	171484108	58,488	357,028	SH		DFND	4 10	0	344,306	12,722
CIENA CORP	COM NEW	171779309	68,071	1,715,272	SH		DFND	4 9 10	0	1,711,138	4,134
CIGNA CORP NEW	COM	125523100	11,348	67,013	SH		DFND	4	0	67,013	0
CIMPRESS PLC	SHS EURO	G2143T103	252,441	3,358,709	SH		DFND	10	0	3,255,495	103,214
CINCINNATI FINL CORP	COM	172062101	55,344	709,803	SH		DFND	4 9	0	568,612	141,191
CINTAS CORP	COM	172908105	138,100	414,921	SH		DFND	4 9	0	117,115	297,806
CISCO SYS INC	COM	17275R102	505,264	12,828,367	SH		DFND	2 4 9 10	0	6,415,234	6,413,133
CITIGROUP INC	COM NEW	172967424	172,285	3,996,902	SH		DFND	2 4 9 10	0	3,834,734	162,168
CITIZENS FINL GROUP INC	COM	174610105	57,772	2,285,314	SH		DFND	2 4 9	0	2,285,314	0
CITRIX SYS INC	COM	177376100	68,744	499,204	SH		DFND	2 4 9	0	416,351	82,853
CLARIVATE PLC	ORD SHS	G21810109	210,802	6,802,256	SH		DFND	10	0	6,531,416	270,840
CLOROX CO DEL	COM	189054109	187,818	893,649	SH		DFND	4 9 10	0	733,633	160,016
CLOUDFLARE INC	CL A COM	18915M107	2,484	60,506	SH		DFND	9	0	51,195	9,311
CME GROUP INC	COM	12572Q105	602,263	3,600,223	SH		DFND	4 9 10	0	3,473,750	126,473
CMS ENERGY CORP	COM	125896100	44,049	717,293	SH		DFND	4 9	0	263,265	454,028
CNA FINL CORP	COM	126117100	1,125	37,505	SH		DFND	9	0	21,697	15,808
CNH INDL N V	SHS	N20944109	2,083	267,092	SH		DFND	4 9	0	78,611	188,481
COCA COLA CO	COM	191216100	281,366	5,701,774	SH		DFND	2 4 9 10	0	5,091,896	609,878
COCA COLA EUROPEAN PARTNERS	SHS	G25839104	9,558	246,342	SH		DFND	4 9	0	220,999	25,343
COCA-COLA FEMSA SAB DE CV	SPONSORD ADR REP	191241108	21,471	527,159	SH		DFND	4	0	527,159	0
CODEXIS INC	COM	192005106	17,960	1,529,770	SH		DFND	10	0	1,426,081	103,689
COGNEX CORP	COM	192422103	316,716	4,865,084	SH		DFND	4 9 10	0	4,410,098	454,986
COGNIZANT TECHNOLOGY SOLUTIO	CL A	192446102	26,678	384,329	SH		DFND	2 4 9	0	280,877	103,452
COHEN & STEERS INC	COM	19247A100	371	6,658	SH		DFND	2 10	0	6,658	0
COHERUS BIOSCIENCES INC	COM	19249H103	27,961	1,524,587	SH		DFND	2	0	1,524,587	0
COLGATE PALMOLIVE CO	COM	194162103	64,774	839,621	SH		DFND	2 4 9 10	0	478,130	361,491
COLLEGIUM PHARMACEUTICAL INC	COM	19459J104	106,647	5,122,359	SH		DFND	10	0	5,034,687	87,672
COLUMBIA SPORTSWEAR CO	COM	198516106	87,267	1,003,300	SH		DFND	2 9 10	0	1,002,919	381
COMCAST CORP NEW	CL A	20030N101	725,476	15,682,917	SH		DFND	2 4 9 10	0	15,588,735	94,182
COMERICA INC	COM	200340107	1,461	38,191	SH		DFND	4 9	0	38,191	0
COMFORT SYS USA INC	COM	199908104	37,946	736,678	SH		DFND	2 4 10	0	736,678	0
COMMERCE BANCSHARES INC	COM	200525103	10,718	190,409	SH		DFND	4 9	0	174,484	15,925
COMMERCIAL METALS CO	COM	201723103	46,028	2,303,727	SH		DFND	2 11	0	2,303,727	0
CONAGRA BRANDS INC	COM	205887102	91,811	2,570,995	SH		DFND	4 9 10	0	437,748	2,133,247
CONCHO RES INC	COM	20605P101	1,861	42,190	SH		DFND	4 9	0	42,190	0
CONOCOPHILLIPS	COM	20825C104	8,971	273,195	SH		DFND	2 4 9 11	0	254,707	18,488
CONSOLIDATED EDISON INC	COM	209115104	132,359	1,701,278	SH		DFND	4 9 10	0	753,126	948,152
CONSTELLATION BRANDS INC	CL A	21036P108	315,887	1,666,866	SH		DFND	4 9 10	0	1,605,971	60,895
CONSTELLIUM SE	CL A SHS	F21107101	66,471	8,467,591	SH		DFND	10	0	8,467,591	0
CONSTRUCTION PARTNERS INC	COM CL A	21044C107	18,585	1,021,142	SH		DFND	10	0	975,084	46,058
CONTINENTAL RES INC	COM	212015101	1,159	94,389	SH		DFND	9	0	94,389	0
COOPER COS INC	COM NEW	216648402	723,537	2,146,258	SH		DFND	4 9 10	0	2,078,150	68,108
COPA HOLDINGS SA	CL A	P31076105	1,435	28,514	SH		DFND	9	0	12,810	15,704
COPART INC	COM	217204106	59,384	564,711	SH		DFND	4 9	0	295,243	269,468
CORCEPT THERAPEUTICS INC	COM	218352102	2,084	119,737	SH		DFND	10	0	119,737	0
CORELOGIC INC	COM	21871D103	264	3,905	SH		DFND	4 9	0	1,626	2,279
CORESITE RLTY CORP	COM	21870Q105	3,763	31,654	SH		DFND	9	0	26,543	5,111
CORNING INC	COM	219350105	385,731	11,901,682	SH		DFND	4 9 10	0	8,726,750	3,174,932
CORTEVA INC	COM	22052L104	34,170	1,186,077	SH		DFND	2 4 9	0	1,130,563	55,514
COSTAR GROUP INC	COM	22160N109	1,136,488	1,339,425	SH		DFND	4 9 10	0	1,241,836	97,589
COSTCO WHSL CORP NEW	COM	22160K105	724,257	2,040,194	SH		DFND	4 9 10	0	1,930,656	109,538
COUPA SOFTWARE INC	COM	22266L106	6,770	24,699	SH		DFND	4 9	0	22,803	1,896
CRACKER BARREL OLD CTRY STOR	COM	22410J106	33,802	294,801	SH		DFND	2	0	294,801	0
CRANE CO	COM	224399105	2,695	53,767	SH		DFND	4 9	0	27,744	26,023
CREDICORP LTD	COM	G2519Y108	1,296	10,455	SH		DFND	4 9	0	10,455	0
CREDIT ACCEP CORP MICH	COM	225310101	289	853	SH		DFND	9 10	0	665	188
CREE INC	COM	225447101	66,164	1,038,032	SH		DFND	9 10	0	1,004,204	33,828
CRITEO S A	SPONS ADS	226718104	23,575	1,935,560	SH		DFND	4	0	1,935,560	0
CROWDSTRIKE HLDGS INC	CL A	22788C105	1,958	14,257	SH		DFND	4 9	0	14,257	0
CROWN CASTLE INTL CORP NEW	COM	22822V101	1,022,005	6,138,370	SH		DFND	2 4 9 10	0	5,625,818	512,552
CROWN HLDGS INC	COM	228368106	558,977	7,272,673	SH		DFND	4 9 10	0	7,116,521	156,152
CRYOPORT INC	COM PAR $0.001	229050307	51,246	1,081,140	SH		DFND	10	0	1,008,206	72,934
CSW INDUSTRIALS INC	COM	126402106	52,426	678,654	SH		DFND	10	0	634,374	44,280
CSX CORP	COM	126408103	341,066	4,391,342	SH		DFND	4 9 10	0	4,148,915	242,427
CUBESMART	COM	229663109	256	7,928	SH		DFND	4 10	0	7,928	0
CUBIC CORP	COM	229669106	77,348	1,329,691	SH		DFND	10	0	1,278,845	50,846
CUMMINS INC	COM	231021106	31,236	147,928	SH		DFND	4 9 10	0	110,696	37,232
CVS HEALTH CORP	COM	126650100	191,085	3,272,041	SH		DFND	4 9	0	1,303,766	1,968,275
CYBERARK SOFTWARE LTD	SHS	M2682V108	2,132	20,612	SH		DFND	4 9	0	19,540	1,072
CYRUSONE INC	COM	23283R100	51,513	735,480	SH		DFND	4 9	0	695,394	40,086
D R HORTON INC	COM	23331A109	7,479	98,888	SH		DFND	4 9	0	98,198	690
DANAHER CORPORATION	COM	235851102	1,057,534	4,911,263	SH		DFND	4 9 10	0	4,505,102	406,161
DARDEN RESTAURANTS INC	COM	237194105	123,743	1,228,343	SH		DFND	4 9	0	374,142	854,201
DATADOG INC	CL A COM	23804L103	2,598	25,428	SH		DFND	4 9	0	25,428	0
DAVITA INC	COM	23918K108	28,752	335,696	SH		DFND	4 9	0	83,639	252,057
DBX ETF TR	XTRACK HRVST CSI	233051879	613	17,776	SH		DFND	10	0	17,776	0
DECIPHERA PHARMACEUTICALS IN	COM	24344T101	17,201	335,306	SH		DFND	10	0	320,203	15,103
DEERE & CO	COM	244199105	522,307	2,356,686	SH		DFND	4 9 10	0	2,347,075	9,611
DELEK US HLDGS INC NEW	COM	24665A103	23,501	2,111,485	SH		DFND	2	0	2,111,485	0
DELL TECHNOLOGIES INC	CL C	24703L202	4,200	62,055	SH		DFND	4 9 10	0	62,055	0
DELTA AIR LINES INC DEL	COM NEW	247361702	11,896	389,004	SH		DFND	4 9 10	0	332,415	56,589
DENISON MINES CORP	COM	248356107	219	523,174	SH		DFND	11	0	523,174	0
DENTSPLY SIRONA INC	COM	24906P109	360,912	8,253,208	SH		DFND	4 9 10	0	7,621,325	631,883
DESCARTES SYS GROUP INC	COM	249906108	68,115	1,199,535	SH		DFND	10	0	1,147,515	52,020
DEUTSCHE BANK A G	NAMEN AKT	D18190898	5,572	657,918	SH		DFND	4 9	0	287,776	370,142
DEVON ENERGY CORP NEW	COM	25179M103	208	21,967	SH		DFND	9	0	21,967	0
DEXCOM INC	COM	252131107	201,339	488,423	SH		DFND	4 9 10	0	274,306	214,117
DIAGEO PLC	SPON ADR NEW	25243Q205	540	3,919	SH		DFND	4 10	0	3,919	0
DIAMONDBACK ENERGY INC	COM	25278X109	4,110	136,428	SH		DFND	4 9 11	0	136,428	0
DIGITAL RLTY TR INC	COM	253868103	59,257	403,817	SH		DFND	4 9	0	237,285	166,532
DISCOVER FINL SVCS	COM	254709108	50,043	866,099	SH		DFND	2 4 9 10	0	741,661	124,438
DISCOVERY INC	COM SER A	25470F104	296	13,648	SH		DFND	4 9	0	11,153	2,495
DISCOVERY INC	COM SER C	25470F302	8,019	409,048	SH		DFND	4 9	0	406,802	2,246
DISH NETWORK CORPORATION	CL A	25470M109	5,984	206,156	SH		DFND	4 9	0	191,718	14,438
DISNEY WALT CO	COM DISNEY	254687106	842,068	6,786,053	SH		DFND	4 9 10	0	6,165,483	620,570
DIVERSIFIED HEALTHCARE TR	COM SH BEN INT	25525P107	198	56,117	SH		DFND	10	0	56,117	0
DMC GLOBAL INC	COM	23291C103	6,856	208,130	SH		DFND	2	0	208,130	0
DOCUSIGN INC	COM	256163106	75,671	351,582	SH		DFND	4 9	0	178,387	173,195
DOLBY LABORATORIES INC	COM CL A	25659T107	241,603	3,645,180	SH		DFND	9 10	0	3,537,117	108,063
DOLLAR GEN CORP NEW	COM	256677105	431,139	2,056,770	SH		DFND	4 9 10	0	1,982,311	74,459
DOLLAR TREE INC	COM	256746108	10,852	118,813	SH		DFND	4 9	0	114,568	4,245
DOMINION ENERGY INC	COM	25746U109	106,129	1,344,849	SH		DFND	4 9	0	1,203,134	141,715
DOMINOS PIZZA INC	COM	25754A201	38,732	91,077	SH		DFND	4 9	0	46,177	44,900
DONALDSON INC	COM	257651109	97,393	2,098,083	SH		DFND	2 10	0	2,018,769	79,314
DOUGLAS EMMETT INC	COM	25960P109	33,631	1,340,397	SH		DFND	4 10 12	0	1,299,853	40,544
DOVER CORP	COM	260003108	30,628	282,701	SH		DFND	4 9	0	240,477	42,224
DOW INC	COM	260557103	9,749	207,272	SH		DFND	4 9	0	207,266	6
DRAGONEER GROWTH OPPORTUN CO	UNIT 08/18/2027	G28302126	67,375	5,500,000	SH		DFND	10	0	5,500,000	0
DROPBOX INC	CL A	26210C104	3,806	197,622	SH		DFND	4 9	0	165,074	32,548
DTE ENERGY CO	COM	233331107	66,395	577,174	SH		DFND	4 9	0	577,174	0
DUKE ENERGY CORP NEW	COM NEW	26441C204	42,560	480,626	SH		DFND	4 9	0	318,604	162,022
DUKE REALTY CORP	COM NEW	264411505	64,351	1,744,520	SH		DFND	4 9 10 12	0	1,622,725	121,795
DUNKIN BRANDS GROUP INC	COM	265504100	475,508	5,805,255	SH		DFND	10	0	5,617,305	187,950
DUPONT DE NEMOURS INC	COM	26614N102	12,310	221,948	SH		DFND	2 4 9	0	194,599	27,349
DYNATRACE INC	COM NEW	268150109	240,311	5,858,380	SH		DFND	4 9 10	0	5,281,596	576,784
DYNE THERAPEUTICS INC	COM	26818M108	19,912	985,963	SH		DFND	10	0	954,699	31,264
E TRADE FINANCIAL CORP	COM NEW	269246401	3,259	65,130	SH		DFND	4 9	0	65,130	0
EAGLE MATLS INC	COM	26969P108	32,289	374,059	SH		DFND	2 9	0	373,681	378
EAGLE PHARMACEUTICALS INC	COM	269796108	72,162	1,698,737	SH		DFND	10	0	1,630,984	67,753
EAST WEST BANCORP INC	COM	27579R104	637	19,452	SH		DFND	4 9	0	19,452	0
EASTERLY GOVT PPTYS INC	COM	27616P103	28,306	1,263,118	SH		DFND	10	0	1,166,578	96,540
EASTMAN CHEM CO	COM	277432100	2,915	37,320	SH		DFND	4 9	0	37,320	0
EATON CORP PLC	SHS	G29183103	94,210	923,364	SH		DFND	4 9 10	0	231,746	691,618
EATON VANCE CORP	COM NON VTG	278265103	4,199	110,058	SH		DFND	9	0	56,977	53,081
EBAY INC.	COM	278642103	121,829	2,338,379	SH		DFND	4 9 10	0	817,788	1,520,591
EBIX INC	COM NEW	278715206	1,563	75,882	SH		DFND	10	0	75,882	0
ECOLAB INC	COM	278865100	30,200	151,169	SH		DFND	4 9 11	0	92,503	58,666
EDISON INTL	COM	281020107	142,041	2,793,926	SH		DFND	4 9	0	966,054	1,827,872
EDWARDS LIFESCIENCES CORP	COM	28176E108	588,746	7,376,000	SH		DFND	4 9 10	0	5,130,347	2,245,653
ELANCO ANIMAL HEALTH INC	COM	28414H103	1,002,161	35,881,245	SH		DFND	4 9 10	0	34,754,727	1,126,518
ELBIT SYS LTD	ORD	M3760D101	213	1,754	SH		DFND	9	0	1,754	0
ELECTRONIC ARTS INC	COM	285512109	151,827	1,164,257	SH		DFND	2 4 9	0	752,526	411,731
EMCOR GROUP INC	COM	29084Q100	61,270	904,891	SH		DFND	2 10	0	904,891	0
EMERSON ELEC CO	COM	291011104	56,675	864,374	SH		DFND	4 9	0	759,746	104,628
ENBRIDGE INC	COM	29250N105	2,577	88,219	SH		DFND	4	0	88,219	0
ENBRIDGE INC	COM	29250N105	77,026	2,643,832	SH		DFND	4 9	0	1,760,696	883,136
ENCOMPASS HEALTH CORP	COM	29261A100	63,676	979,875	SH		DFND	4 9 10	0	889,535	90,340
ENCORE WIRE CORP	COM	292562105	51,189	1,102,734	SH		DFND	2	0	1,102,734	0
ENERGIZER HLDGS INC NEW	COM	29272W109	2,568	65,611	SH		DFND	9	0	35,158	30,453
ENERSYS	COM	29275Y102	106,395	1,585,150	SH		DFND	10	0	1,527,659	57,491
ENSIGN GROUP INC	COM	29358P101	689	12,071	SH		DFND	10	0	12,071	0
ENTEGRIS INC	COM	29362U104	164,294	2,210,033	SH		DFND	9 10	0	2,119,617	90,416
ENTERGY CORP NEW	COM	29364G103	122,023	1,238,442	SH		DFND	2 4 9	0	1,111,398	127,044
ENTERPRISE FINL SVCS CORP	COM	293712105	24,076	882,882	SH		DFND	2 10	0	882,882	0
ENTERPRISE PRODS PARTNERS L	COM	293792107	17,519	1,109,517	SH		DFND	10	0	1,109,517	0
ENVESTNET INC	COM	29404K106	172,201	2,231,740	SH		DFND	10	0	2,144,352	87,388
ENVISTA HOLDINGS CORPORATION	COM	29415F104	44,534	1,804,456	SH		DFND	2	0	1,804,456	0
EOG RES INC	COM	26875P101	12,828	356,949	SH		DFND	4 9	0	317,504	39,445
EPAM SYS INC	COM	29414B104	4,336	13,414	SH		DFND	4 9	0	13,414	0
EQT CORP	COM	26884L109	3,381	261,504	SH		DFND	9	0	219,750	41,754
EQUIFAX INC	COM	294429105	6,554	41,786	SH		DFND	4 9 10	0	41,260	526
EQUINIX INC	COM	29444U700	407,690	536,421	SH		DFND	4 9 10	0	427,995	108,426
EQUITABLE HLDGS INC	COM	29452E101	11,492	630,079	SH		DFND	4 9	0	218,325	411,754
EQUITY COMWLTH	COM SH BEN INT	294628102	97,296	3,653,622	SH		DFND	2 9	0	3,578,391	75,231
EQUITY LIFESTYLE PPTYS INC	COM	29472R108	145,550	2,374,688	SH		DFND	2 4 9 10 12	0	2,354,478	20,210
EQUITY RESIDENTIAL	SH BEN INT	29476L107	8,542	166,428	SH		DFND	2 4 9	0	145,095	21,333
ERIE INDTY CO	CL A	29530P102	20,362	96,834	SH		DFND	4 9	0	28,951	67,883
ESSA PHARMA INC	COM NEW	29668H708	3,256	475,688	SH		DFND	10	0	475,688	0
ESSENTIAL UTILS INC	COM	29670G102	814	20,231	SH		DFND	4 9	0	20,231	0
ESSEX PPTY TR INC	COM	297178105	4,309	21,464	SH		DFND	4 9	0	21,464	0
ETSY INC	COM	29786A106	312,364	2,568,151	SH		DFND	4 9 10	0	2,400,893	167,258
EURONAV NV	SHS	B38564108	17,569	1,990,822	SH		DFND	4	0	1,990,822	0
EURONET WORLDWIDE INC	COM	298736109	263,506	2,892,492	SH		DFND	10	0	2,789,346	103,146
EVERBRIDGE INC	COM	29978A104	34,826	276,990	SH		DFND	9 10	0	262,234	14,756
EVERCORE INC	CLASS A	29977A105	35,202	537,761	SH		DFND	2 9 10	0	536,944	817
EVEREST RE GROUP LTD	COM	G3223R108	68,110	344,790	SH		DFND	4 9	0	203,698	141,092
EVERGY INC	COM	30034W106	82,760	1,628,493	SH		DFND	2 4 9	0	1,511,937	116,556
EVERSOURCE ENERGY	COM	30040W108	43,342	518,773	SH		DFND	4 9	0	257,903	260,870
EVOQUA WATER TECHNOLOGIES CO	COM	30057T105	15,369	724,450	SH		DFND	4 10	0	724,450	0
EXACT SCIENCES CORP	COM	30063P105	6,309	61,876	SH		DFND	4 9 10	0	53,149	8,727
EXELIXIS INC	COM	30161Q104	107,826	4,410,094	SH		DFND	9 10	0	4,255,563	154,531
EXELON CORP	COM	30161N101	39,605	1,107,601	SH		DFND	2 4 9 10	0	973,656	133,945
EXPEDIA GROUP INC	COM NEW	30212P303	3,902	42,563	SH		DFND	4 9	0	42,330	233
EXPEDITORS INTL WASH INC	COM	302130109	35,978	397,469	SH		DFND	4 9	0	127,090	270,379
EXTRA SPACE STORAGE INC	COM	30225T102	24,480	228,823	SH		DFND	4 9	0	172,629	56,194
EXXON MOBIL CORP	COM	30231G102	37,093	1,080,672	SH		DFND	2 4 9	0	1,017,664	63,008
F M C CORP	COM NEW	302491303	30,799	290,817	SH		DFND	4 9 11	0	271,959	18,858
F5 NETWORKS INC	COM	315616102	58,742	478,472	SH		DFND	2 4 9	0	469,790	8,682
FABRINET	SHS	G3323L100	31,191	494,865	SH		DFND	2	0	494,865	0
FACEBOOK INC	CL A	30303M102	3,194,297	12,198,111	SH		DFND	4 9 10	0	10,806,599	1,391,512
FACTSET RESH SYS INC	COM	303075105	16,600	49,570	SH		DFND	4 9	0	12,729	36,841
FAIR ISAAC CORP	COM	303250104	2,079	4,887	SH		DFND	4 9	0	4,887	0
FASTENAL CO	COM	311900104	317,206	7,034,969	SH		DFND	4 9 10	0	3,197,671	3,837,298
FATE THERAPEUTICS INC	COM	31189P102	126,574	3,166,709	SH		DFND	10	0	3,055,046	111,663
FB FINL CORP	COM	30257X104	37,702	1,500,893	SH		DFND	2 10	0	1,500,893	0
FEDERAL RLTY INVT TR	SH BEN INT NEW	313747206	1,672	22,774	SH		DFND	4 9	0	22,774	0
FEDEX CORP	COM	31428X106	12,980	51,633	SH		DFND	4 9	0	51,633	0
FERRARI N V	COM	N3167Y103	14,924	81,232	SH		DFND	4 9	0	43,341	37,891
FIAT CHRYSLER AUTOMOBILES N	SHS	N31738102	4,478	364,884	SH		DFND	4 9	0	163,914	200,970
FIBROGEN INC	COM	31572Q808	136,065	3,308,965	SH		DFND	10	0	3,190,865	118,100
FIDELITY NATIONAL FINANCIAL	FNF GROUP COM	31620R303	5,284	168,783	SH		DFND	4 9	0	157,023	11,760
FIDELITY NATL INFORMATION SV	COM	31620M106	1,034,332	7,026,345	SH		DFND	4 9 10	0	6,421,898	604,447
FIFTH THIRD BANCORP	COM	316773100	36,485	1,711,253	SH		DFND	2 4 9	0	1,464,848	246,405
FIRST AMERN FINL CORP	COM	31847R102	45,555	894,805	SH		DFND	2	0	894,805	0
FIRST HORIZON NATL CORP	COM	320517105	81,144	8,604,901	SH		DFND	2	0	8,604,901	0
FIRST REP BK SAN FRANCISCO C	COM	33616C100	14,277	130,898	SH		DFND	4 9	0	127,404	3,494
FIRST SOLAR INC	COM	336433107	264	3,982	SH		DFND	9	0	1,013	2,969
FIRSTENERGY CORP	COM	337932107	22,514	784,245	SH		DFND	4 9	0	657,097	127,148
FIRSTSERVICE CORP NEW	COM	33767E202	35,085	266,016	SH		DFND	10	0	253,801	12,215
FISERV INC	COM	337738108	145,753	1,414,845	SH		DFND	4 9	0	1,414,845	0
FIVE BELOW INC	COM	33829M101	529	4,169	SH		DFND	10	0	4,169	0
FIVE9 INC	COM	338307101	1,739	13,410	SH		DFND	9	0	8,103	5,307
FLEETCOR TECHNOLOGIES INC	COM	339041105	17,768	74,625	SH		DFND	4 9	0	51,614	23,011
FLEX LNG LTD	SHS	G35947202	12,040	2,139,649	SH		DFND	4	0	2,139,649	0
FLEX LTD	ORD	Y2573F102	267,284	23,993,192	SH		DFND	4 9 10	0	23,319,418	673,774
FLIR SYS INC	COM	302445101	2,152	60,026	SH		DFND	4 9	0	59,493	533
FLOOR & DECOR HLDGS INC	CL A	339750101	580	7,759	SH		DFND	10	0	7,759	0
FLOWERS FOODS INC	COM	343498101	4,089	168,054	SH		DFND	9	0	137,016	31,038
FOCUS FINL PARTNERS INC	COM CL A	34417P100	602	18,363	SH		DFND	4	0	18,363	0
FORD MTR CO DEL	COM	345370860	12,219	1,835,201	SH		DFND	4 9 10	0	1,812,533	22,668
FORMA THERAPEUTICS HLDGS INC	SHS	34633R104	72,169	1,479,342	SH		DFND	10	0	1,437,849	41,493
FORMFACTOR INC	COM	346375108	1,597	64,066	SH		DFND	4 10	0	64,066	0
FORTINET INC	COM	34959E109	17,582	149,264	SH		DFND	4 9	0	149,264	0
FORTIS INC	COM	349553107	4,627	113,588	SH		DFND	4 9	0	113,588	0
FORTIVE CORP	COM	34959J108	4,658	61,127	SH		DFND	4 9	0	61,127	0
FORTUNA SILVER MINES INC	COM	349915108	608	95,847	SH		DFND	11	0	95,847	0
FORTUNE BRANDS HOME & SEC IN	COM	34964C106	6,650	76,863	SH		DFND	4 9 10	0	76,863	0
FOX CORP	CL B COM	35137L204	59,659	2,132,991	SH		DFND	2 4 9	0	2,080,767	52,224
FOX CORP	CL A COM	35137L105	4,350	156,304	SH		DFND	4 9	0	155,134	1,170
FOX FACTORY HLDG CORP	COM	35138V102	536	7,205	SH		DFND	10	0	7,205	0
FRANCO NEV CORP	COM	351858105	16,939	121,636	SH		DFND	4 9	0	65,603	56,033
FRANKLIN RESOURCES INC	COM	354613101	1,005	49,398	SH		DFND	4 9	0	49,398	0
FRANKLIN TEMPLETON ETF TR	FTSE JAPAN ETF	35473P744	11,485	438,879	SH		DFND	10	0	438,879	0
FREEPORT-MCMORAN INC	CL B	35671D857	127,124	8,129,138	SH		DFND	4 9 10 11	0	8,129,138	0
FRONTDOOR INC	COM	35905A109	240,716	6,186,477	SH		DFND	9 10	0	5,964,291	222,186
FRONTLINE LTD	SHS NEW	G3682E192	11,125	1,710,191	SH		DFND	4	0	1,710,191	0
FRONTLINE LTD	SHS NEW	G3682E192	11,849	1,819,856	SH		DFND	4	0	1,819,856	0
FRONTLINE LTD	SHS NEW	G3682E192	724	109,665	SH		DFND	4	0	109,665	0
FS DEV CORP	COM CL A	303020101	2,134	191,414	SH		DFND	10	0	191,414	0
FTI CONSULTING INC	COM	302941109	448	4,224	SH		DFND	9 10	0	4,134	90
FULCRUM THERAPEUTICS INC	COM	359616109	1,403	177,166	SH		DFND	10	0	177,166	0
FULLER H B CO	COM	359694106	77,669	1,696,569	SH		DFND	10	0	1,620,694	75,875
FULTON FINL CORP PA	COM	360271100	42,220	4,525,191	SH		DFND	2	0	4,525,191	0
GALLAGHER ARTHUR J & CO	COM	363576109	26,557	251,561	SH		DFND	4 9	0	219,389	32,172
GARMIN LTD	SHS	H2906T109	174,497	1,839,528	SH		DFND	4 9 10	0	1,140,803	698,725
GARTNER INC	COM	366651107	4,964	39,733	SH		DFND	4 9	0	39,733	0
GATES INDUSTRIAL CORPRATIN P	ORD SHS	G39108108	82,980	7,462,256	SH		DFND	9 10	0	7,182,547	279,709
GATX CORP	COM	361448103	112,041	1,757,509	SH		DFND	2	0	1,757,509	0
GCI LIBERTY INC	COM CLASS A	36164V305	88,595	1,080,953	SH		DFND	9 10	0	1,036,422	44,531
GDS HLDGS LTD	SPONSORED ADS	36165L108	32,703	399,627	SH		DFND	4 9 10 12	0	348,963	50,664
GENERAC HLDGS INC	COM	368736104	1,575	8,134	SH		DFND	2 4 9	0	8,078	56
GENERAL DYNAMICS CORP	COM	369550108	420,404	3,036,946	SH		DFND	4 9 10	0	3,035,918	1,028
GENERAL ELECTRIC CO	COM	369604103	10,806	1,735,342	SH		DFND	4 9	0	1,691,516	43,826
GENERAL MLS INC	COM	370334104	159,646	2,588,335	SH		DFND	4 9 10	0	1,082,261	1,506,074
GENERAL MTRS CO	COM	37045V100	112,231	3,792,931	SH		DFND	4 9	0	2,759,986	1,032,945
GENERATION BIO CO	COM	37148K100	1,169	37,806	SH		DFND	10	0	29,916	7,890
GENESIS HEALTHCARE INC	CL A COM	37185X106	8	15,262	SH		DFND	10	0	15,262	0
GENTEX CORP	COM	371901109	5,859	227,532	SH		DFND	4 9	0	201,117	26,415
GENUINE PARTS CO	COM	372460105	2,976	31,269	SH		DFND	4 9	0	31,269	0
GEOPARK LTD	USD SHS	G38327105	3,268	443,254	SH		DFND	4 10	0	443,254	0
GILDAN ACTIVEWEAR INC	COM	375916103	172,611	8,775,330	SH		DFND	10	0	8,381,145	394,185
GILDAN ACTIVEWEAR INC	COM	375916103	826	42,059	SH		DFND	4 9	0	42,059	0
GILEAD SCIENCES INC	COM	375558103	333,563	5,278,841	SH		DFND	2 4 9 10	0	4,579,710	699,131
GLAUKOS CORP	COM	377322102	88,768	1,792,566	SH		DFND	10	0	1,726,728	65,838
GLOBAL BLOOD THERAPEUTICS IN	COM	37890U108	299,207	5,426,282	SH		DFND	10	0	5,277,651	148,631
GLOBAL PMTS INC	COM	37940X102	703,872	3,963,705	SH		DFND	2 4 9 10	0	3,677,299	286,406
GLOBANT S A	COM	L44385109	1,032	5,759	SH		DFND	4 9	0	5,759	0
GLOBE LIFE INC	COM	37959E102	88,172	1,103,529	SH		DFND	2 4 9	0	1,103,529	0
GLOBUS MED INC	CL A	379577208	314,696	6,354,926	SH		DFND	2 10	0	6,093,243	261,683
GMS INC	COM	36251C103	276	11,465	SH		DFND	10	0	11,465	0
GODADDY INC	CL A	380237107	558,031	7,345,413	SH		DFND	4 9 10	0	7,002,622	342,791
GOLDMAN SACHS GROUP INC	COM	38141G104	98,058	487,952	SH		DFND	4 9 10	0	451,093	36,859
GRACE W R & CO DEL NEW	COM	38388F108	6,409	159,068	SH		DFND	2	0	159,068	0
GRACO INC	COM	384109104	2,778	45,277	SH		DFND	9 10	0	45,277	0
GRAHAM HLDGS CO	COM CL B	384637104	14,249	35,261	SH		DFND	2	0	35,261	0
GRAINGER W W INC	COM	384802104	66,154	185,424	SH		DFND	4 9 10	0	44,244	141,180
GRAND CANYON ED INC	COM	38526M106	623	7,788	SH		DFND	4 9	0	7,691	97
GRANITE REAL ESTATE INVT TR	UNIT 99/99/9999	387437114	29,962	517,885	SH		DFND	4 10 12	0	502,909	14,976
GRANITE REAL ESTATE INVT TR	UNIT 99/99/9999	387437114	7	121	SH		DFND	10	0	121	0
GRAPHIC PACKAGING HLDG CO	COM	388689101	48,893	3,470,057	SH		DFND	2 9	0	3,464,883	5,174
GREENSKY INC	CL A	39572G100	819	184,520	SH		DFND	10	0	184,520	0
GRIFOLS S A	SP ADR REP B NVT	398438408	59,499	3,427,369	SH		DFND	4	0	3,335,131	92,238
GSX TECHEDU INC	SPONSORED ADS	36257Y109	11,042	122,542	SH		DFND	9	0	12,751	109,791
GUARDANT HEALTH INC	COM	40131M109	8,134	72,772	SH		DFND	9	0	52,974	19,798
GUIDEWIRE SOFTWARE INC	COM	40171V100	152,271	1,460,350	SH		DFND	4 9 10	0	1,279,034	181,316
GW PHARMACEUTICALS PLC	ADS	36197T103	198,725	2,041,289	SH		DFND	10	0	1,980,130	61,159
H & E EQUIPMENT SERVICES INC	COM	404030108	24,933	1,268,184	SH		DFND	2	0	1,268,184	0
HAIN CELESTIAL GROUP INC	COM	405217100	24,018	700,226	SH		DFND	9 10	0	678,210	22,016
HALLIBURTON CO	COM	406216101	6,144	509,945	SH		DFND	4 9	0	352,466	157,479
HALOZYME THERAPEUTICS INC	COM	40637H109	23,371	889,303	SH		DFND	10	0	849,706	39,597
HANESBRANDS INC	COM	410345102	242	15,385	SH		DFND	9	0	15,385	0
HANOVER INS GROUP INC	COM	410867105	93,666	1,005,216	SH		DFND	2 9	0	1,003,045	2,171
HARMONY BIOSCIENCES HLDGS IN	COM	413197104	29,661	874,909	SH		DFND	10	0	845,313	29,596
HARTFORD FINL SVCS GROUP INC	COM	416515104	106,489	2,889,023	SH		DFND	2 4 9	0	2,294,369	594,654
HASBRO INC	COM	418056107	523,429	6,327,713	SH		DFND	4 9 10	0	5,307,895	1,019,818
HAWAIIAN ELEC INDUSTRIES	COM	419870100	1,665	50,080	SH		DFND	9	0	50,080	0
HCA HEALTHCARE INC	COM	40412C101	12,519	100,419	SH		DFND	4 9	0	99,855	564
HD SUPPLY HLDGS INC	COM	40416M105	1,321	32,016	SH		DFND	4 9	0	30,764	1,252
HDFC BANK LTD	SPONSORED ADS	40415F101	12,839	256,977	SH		DFND	4 10 12	0	182,942	74,035
HEALTH CATALYST INC	COM	42225T107	45,802	1,251,428	SH		DFND	10	0	1,207,534	43,894
HEALTH SCIENCES ACQ CORP 2	ORD SHS	G4411D109	1,998	180,771	SH		DFND	10	0	180,771	0
HEALTHCARE SVCS GROUP INC	COM	421906108	382	17,724	SH		DFND	10	0	17,724	0
HEALTHEQUITY INC	COM	42226A107	73,914	1,438,853	SH		DFND	10	0	1,388,473	50,380
HEALTHPEAK PROPERTIES INC	COM	42250P103	61,958	2,282,422	SH		DFND	4 9 10 12	0	2,220,915	61,507
HEICO CORP NEW	COM	422806109	8,795	84,028	SH		DFND	4 9 10	0	69,351	14,677
HEICO CORP NEW	CL A	422806208	150,650	1,699,187	SH		DFND	4 9 10	0	1,620,838	78,349
HENRY JACK & ASSOC INC	COM	426281101	12,477	76,739	SH		DFND	4 9 10	0	64,033	12,706
HENRY SCHEIN INC	COM	806407102	13,916	236,755	SH		DFND	4 9	0	56,229	180,526
HERBALIFE NUTRITION LTD	COM SHS	G4412G101	352	7,555	SH		DFND	4	0	7,555	0
HERON THERAPEUTICS INC	COM	427746102	6,881	464,301	SH		DFND	10	0	444,664	19,637
HERSHEY CO	COM	427866108	317,370	2,214,110	SH		DFND	4 9 10	0	2,008,973	205,137
HESKA CORP	COM RESTRC NEW	42805E306	38,249	387,172	SH		DFND	10	0	379,330	7,842
HESS CORP	COM	42809H107	3,190	77,963	SH		DFND	4 9	0	77,963	0
HEWLETT PACKARD ENTERPRISE C	COM	42824C109	26,266	2,803,384	SH		DFND	4 9	0	336,323	2,467,061
HILTON WORLDWIDE HLDGS INC	COM	43300A203	231,045	2,707,988	SH		DFND	4 9 10	0	2,526,463	181,525
HOLOGIC INC	COM	436440101	46,367	697,552	SH		DFND	4 9	0	100,268	597,284
HOME DEPOT INC	COM	437076102	1,505,185	5,420,058	SH		DFND	4 9 10	0	5,285,149	134,909
HONEYWELL INTL INC	COM	438516106	795,899	4,835,128	SH		DFND	2 4 9 10	0	4,504,405	330,723
HORIZON THERAPEUTICS PUB L	SHS	G46188101	694,317	8,938,153	SH		DFND	9 10	0	8,658,982	279,171
HORMEL FOODS CORP	COM	440452100	73,123	1,495,669	SH		DFND	4 9 10	0	607,399	888,270
HOST HOTELS & RESORTS INC	COM	44107P104	6,560	608,005	SH		DFND	4 9	0	562,983	45,022
HOSTESS BRANDS INC	CL A	44109J106	59,172	4,799,061	SH		DFND	10	0	4,621,397	177,664
HOVNANIAN ENTERPRISES INC	CL A NEW	442487401	324	9,967	SH		DFND	10	0	9,967	0
HOWMET AEROSPACE INC	COM	443201108	2,296	137,337	SH		DFND	4 9 10	0	135,298	2,039
HP INC	COM	40434L105	289,964	15,269,355	SH		DFND	4 9	0	5,610,577	9,658,778
HUAZHU GROUP LTD	SPONSORED ADS	44332N106	3,528	81,589	SH		DFND	9	0	15,167	66,422
HUBBELL INC	COM	443510607	6,928	50,628	SH		DFND	9	0	24,466	26,162
HUBSPOT INC	COM	443573100	16,121	55,165	SH		DFND	10	0	37,149	18,016
HUDBAY MINERALS INC	COM	443628102	551	130,839	SH		DFND	11	0	130,839	0
HUMANA INC	COM	444859102	790,374	1,909,680	SH		DFND	2 4 9 10	0	1,723,488	186,192
HUNT J B TRANS SVCS INC	COM	445658107	7,959	62,987	SH		DFND	4 9	0	59,698	3,289
HUNTINGTON BANCSHARES INC	COM	446150104	2,316	252,653	SH		DFND	4 9	0	252,653	0
HUNTINGTON INGALLS INDS INC	COM	446413106	2,091	14,859	SH		DFND	4 9	0	14,859	0
IAA INC	COM	449253103	139,045	2,670,347	SH		DFND	2 9 10	0	2,593,501	76,846
IAC INTERACTIVECORP NEW	COM	44891N109	124,678	1,040,578	SH		DFND	4 9	0	1,000,539	40,039
ICON PLC	SHS	G4705A100	100,990	528,339	SH		DFND	4 10	0	522,207	6,132
ICU MED INC	COM	44930G107	538,642	2,947,263	SH		DFND	9 10	0	2,857,512	89,751
IDEX CORP	COM	45167R104	3,546	19,442	SH		DFND	4 9	0	19,442	0
IDEXX LABS INC	COM	45168D104	16,716	42,527	SH		DFND	4 9	0	42,527	0
IGM BIOSCIENCES INC	COM	449585108	62,366	844,935	SH		DFND	10	0	815,757	29,178
IHS MARKIT LTD	SHS	G47567105	226,258	2,881,909	SH		DFND	4 9 10	0	2,584,971	296,938
ILLINOIS TOOL WKS INC	COM	452308109	16,029	83,035	SH		DFND	4 9	0	83,035	0
ILLUMINA INC	COM	452327109	195,599	632,829	SH		DFND	4 9 10	0	561,426	71,403
IMPERIAL OIL LTD	COM NEW	453038408	794	66,602	SH		DFND	4 9	0	66,602	0
INCYTE CORP	COM	45337C102	10,613	118,260	SH		DFND	4 9 10	0	83,007	35,253
INDEPENDENCE RLTY TR INC	COM	45378A106	209	18,036	SH		DFND	10	0	18,036	0
INDEPENDENT BANK CORP MASS	COM	453836108	22,596	431,379	SH		DFND	2 10	0	431,379	0
INFOSYS LTD	SPONSORED ADR	456788108	348	25,230	SH		DFND	2	0	25,230	0
INGERSOLL RAND INC	COM	45687V106	345,508	9,705,296	SH		DFND	4 9 10	0	9,323,881	381,415
INGEVITY CORP	COM	45688C107	837	16,923	SH		DFND	10	0	16,923	0
INGLES MKTS INC	CL A	457030104	10,539	277,041	SH		DFND	2	0	277,041	0
INGREDION INC	COM	457187102	1,559	20,611	SH		DFND	4 9	0	20,611	0
INNOSPEC INC	COM	45768S105	47,713	753,528	SH		DFND	2	0	753,528	0
INNOVIVA INC	COM	45781M101	1,351	129,238	SH		DFND	10	0	129,238	0
INOGEN INC	COM	45780L104	816	28,125	SH		DFND	10	0	28,125	0
INSIGHT ENTERPRISES INC	COM	45765U103	14,322	253,124	SH		DFND	2 10	0	253,124	0
INSMED INC	COM PAR $.01	457669307	198,278	6,169,167	SH		DFND	10	0	5,964,812	204,355
INSPERITY INC	COM	45778Q107	686	10,475	SH		DFND	10	0	10,475	0
INSTALLED BLDG PRODS INC	COM	45780R101	527	5,181	SH		DFND	10	0	5,181	0
INSULET CORP	COM	45784P101	129,488	547,292	SH		DFND	4 9 10	0	328,274	219,018
INTEGRA LIFESCIENCES HLDGS C	COM NEW	457985208	191,235	4,049,872	SH		DFND	10	0	3,908,617	141,255
INTEL CORP	COM	458140100	641,392	12,387,006	SH		DFND	2 4 9 10	0	11,633,277	753,729
INTELLIGENT SYS CORP NEW	COM	45816D100	18,611	482,453	SH		DFND	10	0	466,834	15,619
INTERACTIVE BROKERS GROUP IN	COM CL A	45841N107	2,741	56,708	SH		DFND	9	0	50,411	6,297
INTERCONTINENTAL EXCHANGE IN	COM	45866F104	111,627	1,116,216	SH		DFND	4 9 10	0	1,018,476	97,740
INTERNATIONAL BUSINESS MACHS	COM	459200101	325,192	2,672,767	SH		DFND	4 9	0	1,222,227	1,450,540
INTERNATIONAL FLAVORS&FRAGRA	COM	459506101	26	208	SH		DFND	4	0	208	0
INTERNATIONAL FLAVORS&FRAGRA	COM	459506101	20,654	168,678	SH		DFND	4 9	0	99,668	69,010
INTERNATIONAL PAPER CO	COM	460146103	3,850	94,979	SH		DFND	4 9	0	94,179	800
INTERPUBLIC GROUP COS INC	COM	460690100	32,507	1,950,082	SH		DFND	4 9	0	520,267	1,429,815
INTUIT	COM	461202103	582,826	1,786,948	SH		DFND	4 9 10	0	1,221,301	565,647
INTUITIVE SURGICAL INC	COM NEW	46120E602	698,556	984,537	SH		DFND	4 9 10	0	932,714	51,823
INVESCO LTD	SHS	G491BT108	935	81,919	SH		DFND	4 9	0	81,919	0
INVESCO QQQ TR	UNIT SER 1	46090E103	3	400	SH	Put	DFND	10	0	4	0
INVESCO QQQ TR	UNIT SER 1	46090E103	70	4,500	SH	Call	DFND	10	0	45	0
INVESCO QQQ TR	UNIT SER 1	46090E103	36,586	131,681	SH		DFND	10	0	131,681	0
INVESCO QQQ TR	UNIT SER 1	46090E103	3	200	SH	Call	DFND	10	0	2	0
INVESCO QQQ TR	UNIT SER 1	46090E103	308	37,100	SH	Put	DFND	10	0	371	0
INVESCO QQQ TR	UNIT SER 1	46090E103	304	36,700	SH	Put	DFND	10	0	367	0
INVESCO QQQ TR	UNIT SER 1	46090E103	73	4,700	SH	Call	DFND	10	0	47	0
INVITATION HOMES INC	COM	46187W107	62,126	2,220,738	SH		DFND	4 9 10 12	0	2,160,268	60,470
IONIS PHARMACEUTICALS INC	COM	462222100	2,879	60,679	SH		DFND	4 9 10	0	56,828	3,851
IPG PHOTONICS CORP	COM	44980X109	35,976	211,800	SH		DFND	4 9 10	0	211,619	181
IQVIA HLDGS INC	COM	46266C105	517,480	3,282,866	SH		DFND	4 9 10	0	2,989,321	293,545
IRADIMED CORP	COM	46266A109	267	12,483	SH		DFND	10	0	12,483	0
IRON MTN INC NEW	COM	46284V101	3,663	136,752	SH		DFND	4 9	0	136,752	0
IRONWOOD PHARMACEUTICALS INC	COM CL A	46333X108	30,460	3,386,302	SH		DFND	10	0	3,267,029	119,273
ISHARES INC	EM MKTS DIV ETF	464286319	145	149,500	SH	Call	DFND	10	0	1,495	0
ISHARES TR	IBOXX INV CP ETF	464287242	440	3,265	SH		DFND	10	0	3,265	0
ISHARES TR	RUSSELL 2000 ETF	464287655	145	26,000	SH	Call	DFND	10	0	260	0
ISHARES TR	RUSSELL 2000 ETF	464287655	144	25,700	SH	Call	DFND	10	0	257	0
ISHARES TR	AGENCY BOND ETF	464288166	409	3,381	SH		DFND	10	0	3,381	0
ISHARES TR	CORE US AGGBD ET	464287226	92,055	779,730	SH		DFND	10	0	779,730	0
ISHARES TR	BARCLAYS 7 10 YR	464287440	435	3,573	SH		DFND	10	0	3,573	0
ISHARES TR	RUSSELL 2000 ETF	464287655	2	300	SH	Call	DFND	10	0	3	0
ISHARES TR	20 YR TR BD ETF	464287432	864	5,291	SH		DFND	10	0	5,291	0
ITAU UNIBANCO HLDG S A	SPON ADR REP PFD	465562106	846	212,569	SH		DFND	4 10	0	212,569	0
ITEOS THERAPEUTICS INC	COM	46565G104	24,666	999,832	SH		DFND	10	0	956,651	43,181
ITRON INC	COM	465741106	69,808	1,149,292	SH		DFND	10	0	1,106,421	42,871
ITT INC	COM	45073V108	121,933	2,064,913	SH		DFND	4 9 10	0	2,002,218	62,695
J P MORGAN EXCHANGE-TRADED F	BETABULDR DEVE	46641Q688	11,504	509,012	SH		DFND	10	0	509,012	0
J2 GLOBAL INC	COM	48123V102	127,675	1,844,487	SH		DFND	10	0	1,771,717	72,770
JACOBS ENGR GROUP INC	COM	469814107	10,396	112,063	SH		DFND	4 9	0	105,547	6,516
JANUS DETROIT STR TR	HENDRSN SHRT ETF	47103U886	23,481	465,990	SH		DFND	10	0	364,991	100,999
JAZZ PHARMACEUTICALS PLC	SHS USD	G50871105	133,096	933,398	SH		DFND	4 9 10	0	905,258	28,140
JD.COM INC	SPON ADR CL A	47215P106	67,924	875,229	SH		DFND	4 9 10 12	0	763,978	111,251
JEFFERIES FINL GROUP INC	COM	47233W109	5,763	320,190	SH		DFND	9	0	176,085	144,105
JFROG LTD	ORD SHS	M6191J100	27,306	322,574	SH		DFND	10	0	289,232	33,342
JOHN BEAN TECHNOLOGIES CORP	COM	477839104	71,425	777,292	SH		DFND	4 10	0	749,204	28,088
JOHNSON & JOHNSON	COM	478160104	442,631	2,973,593	SH		DFND	2 4 9 10	0	2,594,735	378,858
JOHNSON CTLS INTL PLC	SHS	G51502105	139,771	3,421,605	SH		DFND	4 9 10	0	1,218,370	2,203,235
JOINT CORP	COM	47973J102	311	17,858	SH		DFND	10	0	17,858	0
JONES LANG LASALLE INC	COM	48020Q107	38,955	407,228	SH		DFND	4 9 10	0	397,006	10,222
JPMORGAN CHASE & CO	COM	46625H100	391,291	4,064,787	SH		DFND	4 9 10	0	3,871,320	193,467
JUNIPER NETWORKS INC	COM	48203R104	12,224	568,582	SH		DFND	4 9	0	389,084	179,498
K12 INC	COM	48273U102	26,303	998,595	SH		DFND	10	0	956,845	41,750
KADANT INC	COM	48282T104	410	3,744	SH		DFND	4 10	0	3,744	0
KALVISTA PHARMACEUTICALS INC	COM	483497103	2,131	169,009	SH		DFND	10	0	169,009	0
KANSAS CITY SOUTHERN	COM NEW	485170302	58,338	322,614	SH		DFND	4 9 10	0	317,107	5,507
KB HOME	COM	48666K109	272	7,088	SH		DFND	10	0	7,088	0
KEARNY FINL CORP MD	COM	48716P108	762	105,663	SH		DFND	10	0	76,148	29,515
KELLOGG CO	COM	487836108	206,954	3,204,115	SH		DFND	4 9 10	0	1,158,551	2,045,564
KENSINGTON CAP ACQUISITION C	COM CL A	490073103	1,666	99,457	SH		DFND	10	0	84,886	14,571
KEURIG DR PEPPER INC	COM	49271V100	7,159	259,390	SH		DFND	4 9 10	0	213,132	46,258
KEYCORP	COM	493267108	3,388	284,032	SH		DFND	4 9	0	284,032	0
KEYSIGHT TECHNOLOGIES INC	COM	49338L103	110,679	1,120,784	SH		DFND	4 9 10	0	1,006,983	113,801
KIMBERLY CLARK CORP	COM	494368103	154,801	1,048,374	SH		DFND	4 9 10	0	500,354	548,020
KIMCO RLTY CORP	COM	49446R109	3,620	321,494	SH		DFND	4 9	0	317,580	3,914
KINDER MORGAN INC DEL	COM	49456B101	8,095	656,625	SH		DFND	4 9	0	650,610	6,015
KINGSOFT CLOUD HLDGS LTD	ADS	49639K101	737	25,000	SH		DFND	4	0	25,000	0
KINIKSA PHARMACEUTICALS LTD	COM CL A	G5269C101	17,132	1,118,261	SH		DFND	10	0	1,069,201	49,060
KINROSS GOLD CORP	COM	496902404	7,746	880,546	SH		DFND	4 9 11	0	880,546	0
KINSALE CAP GROUP INC	COM	49714P108	272	1,430	SH		DFND	10	0	1,430	0
KIRKLAND LAKE GOLD LTD	COM	49741E100	1,633	33,580	SH		DFND	4 9	0	33,580	0
KKR & CO INC	COM	48251W104	3,792	110,450	SH		DFND	4 9 10	0	110,450	0
KLA CORP	COM NEW	482480100	700,816	3,617,309	SH		DFND	4 9 10	0	3,329,405	287,904
KNIGHT SWIFT TRANSN HLDGS IN	CL A	499049104	3,312	81,390	SH		DFND	4 9	0	58,795	22,595
KORN FERRY	COM NEW	500643200	45,305	1,562,243	SH		DFND	2	0	1,562,243	0
KORNIT DIGITAL LTD	SHS	M6372Q113	46,530	717,285	SH		DFND	4 10	0	687,406	29,879
KRAFT HEINZ CO	COM	500754106	188,726	6,301,899	SH		DFND	4 9	0	2,517,341	3,784,558
KROGER CO	COM	501044101	84,954	2,505,313	SH		DFND	4 9 10	0	957,492	1,547,821
L3HARRIS TECHNOLOGIES INC	COM	502431109	1,120,458	6,597,192	SH		DFND	4 9 10	0	6,366,575	230,617
LABORATORY CORP AMER HLDGS	COM NEW	50540R409	99,066	526,194	SH		DFND	2 4 9	0	517,484	8,710
LAIRD SUPERFOOD INC	COM STK	50736T102	6,935	151,185	SH		DFND	10	0	99,025	52,160
LAM RESEARCH CORP	COM	512807108	1,641,932	4,949,656	SH		DFND	4 9 10	0	4,612,464	337,192
LAMAR ADVERTISING CO NEW	CL A	512816109	492,124	7,437,266	SH		DFND	2 4 9 10	0	7,242,532	194,734
LAMB WESTON HLDGS INC	COM	513272104	56,610	854,226	SH		DFND	2 4 9	0	719,556	134,670
LANDSTAR SYS INC	COM	515098101	4,091	32,603	SH		DFND	9	0	27,536	5,067
LARIMAR THERAPEUTICS INC	COM	517125100	2,537	163,599	SH		DFND	10	0	163,599	0
LAS VEGAS SANDS CORP	COM	517834107	18,459	395,683	SH		DFND	4 9 10	0	338,852	56,831
LAS VEGAS SANDS CORP	COM	517834107	1	300	SH	Call	DFND	10	0	3	0
LAS VEGAS SANDS CORP	COM	517834107	122	45,500	SH	Call	DFND	10	0	455	0
LAS VEGAS SANDS CORP	COM	517834107	121	45,200	SH	Call	DFND	10	0	452	0
LAUDER ESTEE COS INC	CL A	518439104	301,933	1,383,583	SH		DFND	4 9 10	0	1,036,800	346,783
LCI INDS	COM	50189K103	465	4,373	SH		DFND	10	0	4,373	0
LEAR CORP	COM NEW	521865204	1,592	14,601	SH		DFND	4 9	0	14,601	0
LEGGETT & PLATT INC	COM	524660107	44,375	1,077,837	SH		DFND	2 9 10	0	1,002,911	74,926
LEIDOS HOLDINGS INC	COM	525327102	76,756	860,975	SH		DFND	4 9	0	379,809	481,166
LEMAITRE VASCULAR INC	COM	525558201	839	25,781	SH		DFND	10	0	25,781	0
LENDINGTREE INC NEW	COM	52603B107	113,456	369,696	SH		DFND	10	0	356,068	13,628
LENNAR CORP	CL A	526057104	25,291	309,658	SH		DFND	4 9 10	0	267,273	42,385
LENNOX INTL INC	COM	526107107	1,602	5,876	SH		DFND	4 9	0	5,876	0
LEVI STRAUSS & CO NEW	CL A COM STK	52736R102	36,735	2,741,413	SH		DFND	2	0	2,741,413	0
LGI HOMES INC	COM	50187T106	507	4,362	SH		DFND	10	0	4,362	0
LHC GROUP INC	COM	50187A107	2,801	13,178	SH		DFND	10	0	13,178	0
LIBERTY BROADBAND CORP	COM SER C	530307305	30,013	210,063	SH		DFND	4 9 10	0	208,619	1,444
LIBERTY BROADBAND CORP	COM SER A	530307107	2,023	14,267	SH		DFND	4 9	0	13,335	932
LIBERTY GLOBAL PLC	SHS CL A	G5480U104	13,342	635,032	SH		DFND	4 9	0	111,061	523,971
LIBERTY GLOBAL PLC	SHS CL C	G5480U120	14,977	729,318	SH		DFND	4 9	0	146,839	582,479
LIBERTY MEDIA CORP DEL	COM A SIRIUSXM	531229409	445	13,410	SH		DFND	4 9	0	13,410	0
LIBERTY MEDIA CORP DEL	COM SER C FRMLA	531229854	499,091	13,760,435	SH		DFND	4 9 10	0	13,101,185	659,250
LIBERTY MEDIA CORP DEL	COM C SIRIUSXM	531229607	1,720	51,979	SH		DFND	4 9	0	51,979	0
LIGAND PHARMACEUTICALS INC	COM NEW	53220K504	153,088	1,606,041	SH		DFND	10	0	1,542,524	63,517
LILLY ELI & CO	COM	532457108	861,839	5,822,625	SH		DFND	4 9 10	0	5,636,792	185,833
LINCOLN ELEC HLDGS INC	COM	533900106	114,877	1,248,122	SH		DFND	2	0	1,248,122	0
LINCOLN NATL CORP IND	COM	534187109	1,542	49,217	SH		DFND	4 9	0	49,217	0
LINDE PLC	SHS	G5494J103	42,802	179,756	SH		DFND	4 9	0	168,755	11,001
LITHIA MTRS INC	CL A	536797103	472	2,069	SH		DFND	4 10	0	2,069	0
LITTELFUSE INC	COM	537008104	20,458	115,361	SH		DFND	2 9	0	115,309	52
LIVE NATION ENTERTAINMENT IN	COM	538034109	19,009	352,806	SH		DFND	4 9	0	138,144	214,662
LIVENT CORP	COM	53814L108	538	59,962	SH		DFND	10	0	59,962	0
LIVEPERSON INC	COM	538146101	147,112	2,829,611	SH		DFND	10	0	2,712,371	117,240
LIVERAMP HLDGS INC	COM	53815P108	118,952	2,297,694	SH		DFND	10	0	2,205,477	92,217
LIVONGO HEALTH INC	COM	539183103	1,176	8,398	SH		DFND	9	0	8,398	0
LKQ CORP	COM	501889208	1,760	63,477	SH		DFND	4 9	0	61,413	2,064
LOCKHEED MARTIN CORP	COM	539830109	126,624	330,370	SH		DFND	4 9 10	0	327,535	2,835
LOEWS CORP	COM	540424108	2,583	74,339	SH		DFND	4 9	0	74,339	0
LOGITECH INTL S A	SHS	H50430232	4,369	56,053	SH		DFND	4 9	0	25,924	30,129
LOVESAC COMPANY	COM	54738L109	24,408	880,829	SH		DFND	10	0	840,660	40,169
LOWES COS INC	COM	548661107	216,940	1,308,003	SH		DFND	4 9 10	0	943,725	364,278
LPL FINL HLDGS INC	COM	50212V100	625,669	8,160,539	SH		DFND	9 10	0	7,877,130	283,409
LTC PPTYS INC	COM	502175102	320	9,190	SH		DFND	10	0	9,190	0
LULULEMON ATHLETICA INC	COM	550021109	172,202	522,827	SH		DFND	4 9 10	0	336,591	186,236
LUMEN TECHNOLOGIES INC	COM	156700106	84,080	8,333,253	SH		DFND	4 9	0	2,536,580	5,796,673
LUMENTUM HLDGS INC	COM	55024U109	80,118	1,066,460	SH		DFND	4	0	1,066,460	0
LYFT INC	CL A COM	55087P104	554	20,100	SH		DFND	4	0	20,100	0
LYONDELLBASELL INDUSTRIES N	SHS - A -	N53745100	21,172	300,334	SH		DFND	4 9	0	257,120	43,214
M & T BK CORP	COM	55261F104	61,954	672,760	SH		DFND	2 4 9	0	660,684	12,076
M D C HLDGS INC	COM	552676108	519	11,025	SH		DFND	10	0	11,025	0
M/I HOMES INC	COM	55305B101	229	4,963	SH		DFND	10	0	4,963	0
MACQUARIE INFRASTRUCTURE COR	COM	55608B105	2,398	89,192	SH		DFND	9	0	48,045	41,147
MADDEN STEVEN LTD	COM	556269108	42,094	2,158,680	SH		DFND	2	0	2,158,680	0
MADISON SQUARE GRDN ENTERTNM	CL A	55826T102	1,573	22,960	SH		DFND	9	0	10,848	12,112
MADISON SQUARE GRDN SPRT COR	CL A	55825T103	27,990	186,006	SH		DFND	2 9	0	180,822	5,184
MAGELLAN MIDSTREAM PRTNRS LP	COM UNIT RP LP	559080106	262,069	7,662,826	SH		DFND	10	0	7,662,826	0
MAGNA INTL INC	COM	559222401	3,828	83,969	SH		DFND	4 9	0	83,969	0
MANCHESTER UTD PLC NEW	ORD CL A	G5784H106	15,870	1,091,467	SH		DFND	10	0	1,042,571	48,896
MANPOWERGROUP INC	COM	56418H100	2,368	32,298	SH		DFND	9	0	16,202	16,096
MANULIFE FINL CORP	COM	56501R106	151,482	10,925,567	SH		DFND	4 9	0	7,172,607	3,752,960
MANULIFE FINL CORP	COM	56501R106	1	107	SH		DFND	4	0	107	0
MARATHON OIL CORP	COM	565849106	287	70,251	SH		DFND	9	0	70,251	0
MARATHON PETE CORP	COM	56585A102	24,564	837,224	SH		DFND	2 4 9 10	0	732,469	104,755
MARCUS & MILLICHAP INC	COM	566324109	42,309	1,537,407	SH		DFND	2	0	1,537,407	0
MARKEL CORP	COM	570535104	2,770	2,840	SH		DFND	4 9	0	2,840	0
MARKETAXESS HLDGS INC	COM	57060D108	44,745	92,908	SH		DFND	4 9 10	0	37,527	55,381
MARRIOTT INTL INC NEW	CL A	571903202	6,391	69,057	SH		DFND	4 9	0	69,057	0
MARSH & MCLENNAN COS INC	COM	571748102	233,187	2,033,247	SH		DFND	4 9 10	0	1,986,561	46,686
MARTEN TRANS LTD	COM	573075108	362	22,176	SH		DFND	10	0	22,176	0
MARTIN MARIETTA MATLS INC	COM	573284106	52,309	222,249	SH		DFND	2 4 9	0	211,501	10,748
MARVELL TECHNOLOGY GROUP LTD	ORD	G5876H105	245,067	6,173,957	SH		DFND	4 9 10	0	6,173,957	0
MASCO CORP	COM	574599106	5,734	104,014	SH		DFND	4 9	0	103,859	155
MASIMO CORP	COM	574795100	11,159	47,270	SH		DFND	4 9	0	29,054	18,216
MASTERCARD INCORPORATED	CL A	57636Q104	3,758,648	11,115,130	SH		DFND	4 9 10	0	10,161,646	953,484
MATCH GROUP INC NEW	COM	57667L107	377,759	3,413,806	SH		DFND	4 9 10	0	2,980,701	433,105
MAXIM INTEGRATED PRODS INC	COM	57772K101	80,896	1,196,520	SH		DFND	2 4 9	0	1,070,862	125,658
MAXIMUS INC	COM	577933104	64,318	940,187	SH		DFND	10	0	904,852	35,335
MCCORMICK & CO INC	COM NON VTG	579780206	87,975	453,297	SH		DFND	4 9 10	0	392,345	60,952
MCDONALDS CORP	COM	580135101	1,361,056	6,201,077	SH		DFND	4 9 10	0	5,440,437	760,640
MCGRATH RENTCORP	COM	580589109	385	6,461	SH		DFND	10	0	6,461	0
MCKESSON CORP	COM	58155Q103	11,053	74,225	SH		DFND	4 9 10	0	56,770	17,455
MEDALLIA INC	COM	584021109	28,444	1,037,330	SH		DFND	10	0	948,090	89,240
MEDICAL PPTYS TRUST INC	COM	58463J304	17,117	970,893	SH		DFND	4 9	0	389,543	581,350
MEDIFAST INC	COM	58470H101	1,070	6,507	SH		DFND	10	0	6,507	0
MEDPACE HLDGS INC	COM	58506Q109	2,401	21,488	SH		DFND	10	0	21,488	0
MEDTRONIC PLC	SHS	G5960L103	750,430	7,222,280	SH		DFND	2 4 9 10	0	6,457,014	765,266
MELCO RESORTS AND ENTMNT LTD	ADR	585464100	16,564	994,555	SH		DFND	4 9 12	0	994,555	0
MERCADOLIBRE INC	COM	58733R102	81,538	75,333	SH		DFND	4 9 10	0	74,157	1,176
MERCK & CO. INC	COM	58933Y105	2,300,923	27,740,360	SH		DFND	2 4 9 10	0	25,129,137	2,611,223
MERCURY GENL CORP NEW	COM	589400100	450	10,888	SH		DFND	9	0	9,120	1,768
MERSANA THERAPEUTICS INC	COM	59045L106	16,922	908,845	SH		DFND	10	0	870,908	37,937
METLIFE INC	COM	59156R108	7,321	196,970	SH		DFND	4 9	0	196,970	0
METTLER TOLEDO INTERNATIONAL	COM	592688105	13,705	14,199	SH		DFND	4 9	0	8,284	5,915
MGIC INVT CORP WIS	COM	552848103	45,413	5,125,595	SH		DFND	10	0	5,094,140	31,455
MGM GROWTH PPTYS LLC	CL A COM	55303A105	199,424	7,127,564	SH		DFND	4 10 12	0	6,646,988	480,576
MGM RESORTS INTERNATIONAL	COM	552953101	3,734	171,688	SH		DFND	4 9 10	0	171,688	0
MGP INGREDIENTS INC NEW	COM	55303J106	372	9,355	SH		DFND	10	0	9,355	0
MICROCHIP TECHNOLOGY INC.	COM	595017104	1,129,555	10,991,759	SH		DFND	4 9 10	0	10,301,473	690,286
MICRON TECHNOLOGY INC	COM	595112103	103,843	2,211,185	SH		DFND	4 9 10	0	2,091,447	119,738
MICROSOFT CORP	COM	594918104	9,860,307	46,883,536	SH		DFND	2 4 9 10	0	40,907,991	5,975,545
MID-AMER APT CMNTYS INC	COM	59522J103	57,983	500,076	SH		DFND	4 9	0	280,315	219,761
MIDDLEBY CORP	COM	596278101	118,736	1,323,556	SH		DFND	10	0	1,284,442	39,114
MIRATI THERAPEUTICS INC	COM	60468T105	311,970	1,878,780	SH		DFND	10	0	1,818,895	59,885
MOBILE TELESYSTEMS PJSC	SPONSORED ADR	607409109	578	66,176	SH		DFND	9	0	66,176	0
MODERNA INC	COM	60770K107	7,349	103,900	SH		DFND	4 9 10	0	103,900	0
MOHAWK INDS INC	COM	608190104	1,654	16,954	SH		DFND	4 9	0	16,954	0
MOLINA HEALTHCARE INC	COM	60855R100	1,121	6,125	SH		DFND	4 9	0	5,581	544
MOLSON COORS BEVERAGE CO	CL B	60871R209	2,609	77,749	SH		DFND	4 9	0	76,876	873
MOMO INC	ADR	60879B107	463	33,647	SH		DFND	9	0	33,647	0
MONARCH CASINO & RESORT INC	COM	609027107	39,066	875,918	SH		DFND	10	0	861,588	14,330
MONDELEZ INTL INC	CL A	609207105	40,826	710,782	SH		DFND	4 9 10	0	679,961	30,821
MONGODB INC	CL A	60937P106	56,433	243,758	SH		DFND	4 9 10	0	103,358	140,400
MONOLITHIC PWR SYS INC	COM	609839105	3,652	13,062	SH		DFND	10	0	13,062	0
MONSTER BEVERAGE CORP NEW	COM	61174X109	373,671	4,659,243	SH		DFND	4 9 10	0	4,248,971	410,272
MONTROSE ENVIRONMENTAL GROUP	COM	615111101	16,689	700,646	SH		DFND	10	0	670,380	30,266
MOODYS CORP	COM	615369105	69,536	239,928	SH		DFND	4 9	0	235,655	4,273
MORGAN STANLEY	COM NEW	617446448	476,000	9,844,955	SH		DFND	4 9 10	0	9,781,845	63,110
MORNINGSTAR INC	COM	617700109	3,779	23,531	SH		DFND	9	0	8,856	14,675
MOSAIC CO NEW	COM	61945C103	7,515	411,628	SH		DFND	4 9 11	0	411,628	0
MOTOROLA SOLUTIONS INC	COM NEW	620076307	322,332	2,055,727	SH		DFND	2 4 9 10	0	1,997,879	57,848
MSC INDL DIRECT INC	CL A	553530106	43,964	694,750	SH		DFND	2	0	694,750	0
MSCI INC	COM	55354G100	179,547	503,248	SH		DFND	4 9 10	0	468,451	34,797
MYLAN NV	SHS EURO	N59465109	8,518	574,408	SH		DFND	4 9	0	509,146	65,262
MYOKARDIA INC	COM	62857M105	98,701	723,989	SH		DFND	10	0	695,223	28,766
MYOVANT SCIENCES LTD	COM	G637AM102	55,686	3,963,483	SH		DFND	10	0	3,826,664	136,819
NAPCO SEC TECHNOLOGIES INC	COM	630402105	3,195	135,971	SH		DFND	10	0	131,950	4,021
NASDAQ INC	COM	631103108	4,119	33,571	SH		DFND	4 9	0	33,571	0
NATERA INC	COM	632307104	62,885	870,497	SH		DFND	10	0	833,880	36,617
NATIONAL BEVERAGE CORP	COM	635017106	1,754	25,792	SH		DFND	10	0	25,792	0
NATIONAL GEN HLDGS CORP	COM	636220303	242	7,185	SH		DFND	10	0	7,185	0
NATIONAL GRID PLC	SPONSORED ADR NE	636274409	289	5,000	SH		DFND	4	0	5,000	0
NATIONAL HEALTH INVS INC	COM	63633D104	612	10,147	SH		DFND	10	0	10,147	0
NATIONAL INSTRS CORP	COM	636518102	319,459	8,948,432	SH		DFND	9 10	0	8,661,486	286,946
NATIONAL OILWELL VARCO INC	COM	637071101	1,041	114,987	SH		DFND	4 9	0	114,987	0
NATIONAL RESH CORP	COM NEW	637372202	1,583	32,172	SH		DFND	10	0	32,172	0
NATIONAL RETAIL PROPERTIES I	COM	637417106	745	21,593	SH		DFND	4 9	0	21,593	0
NATIONAL STORAGE AFFILIATES	COM SHS BEN IN	637870106	6,541	200,000	SH		DFND	4	0	200,000	0
NATIONAL VISION HLDGS INC	COM	63845R107	108,031	2,825,074	SH		DFND	10	0	2,728,947	96,127
NATUS MED INC DEL	COM	639050103	13,079	763,502	SH		DFND	2	0	763,502	0
NCR CORP NEW	COM	62886E108	58,508	2,642,632	SH		DFND	10	0	2,548,822	93,810
NEKTAR THERAPEUTICS	COM	640268108	827	49,839	SH		DFND	9	0	47,789	2,050
NEOGENOMICS INC	COM NEW	64049M209	98,866	2,680,031	SH		DFND	4 10	0	2,573,537	106,494
NETAPP INC	COM	64110D104	18,798	428,799	SH		DFND	4 9	0	268,906	159,893
NETEASE INC	SPONSORED ADS	64110W102	66,706	146,729	SH		DFND	4 9 12	0	116,709	30,020
NETFLIX INC	COM	64110L106	1,783,528	3,567,013	SH		DFND	4 9 10	0	2,994,522	572,491
NEUROCRINE BIOSCIENCES INC	COM	64125C109	629,695	6,548,393	SH		DFND	4 9 10	0	6,175,028	373,365
NEW ORIENTAL ED & TECHNOLOGY	SPON ADR	647581107	80,825	540,617	SH		DFND	4 9 10 12	0	508,903	31,714
NEW RESIDENTIAL INVT CORP	COM NEW	64828T201	3,716	467,429	SH		DFND	9	0	241,788	225,641
NEW SR INVT GROUP INC	COM	648691103	73	18,280	SH		DFND	10	0	18,280	0
NEW YORK CMNTY BANCORP INC	COM	649445103	5,750	695,253	SH		DFND	9	0	622,548	72,705
NEW YORK TIMES CO	CL A	650111107	9,114	212,994	SH		DFND	9	0	139,930	73,064
NEWELL BRANDS INC	COM	651229106	54,572	3,180,149	SH		DFND	4 9	0	1,040,961	2,139,188
NEWMARK GROUP INC	CL A	65158N102	153	35,349	SH		DFND	10	0	35,349	0
NEWMARKET CORP	COM	651587107	99,358	290,248	SH		DFND	2	0	290,248	0
NEWMONT CORP	COM	651639106	3,614	57,207	SH		DFND	4	0	57,207	0
NEWMONT CORP	COM	651639106	227,142	3,579,806	SH		DFND	4 9	0	1,865,927	1,713,879
NEWS CORP NEW	CL A	65249B109	5,299	378,047	SH		DFND	4 9	0	274,593	103,454
NEXGEN ENERGY LTD	COM	65340P106	4,481	2,582,944	SH		DFND	11	0	2,582,944	0
NEXPOINT RESIDENTIAL TR INC	COM	65341D102	241	5,436	SH		DFND	10	0	5,436	0
NEXTERA ENERGY INC	COM	65339F101	129,848	467,894	SH		DFND	4 9	0	266,977	200,917
NICE LTD	SPONSORED ADR	653656108	955,641	4,209,315	SH		DFND	10	0	3,990,523	218,792
NIELSEN HLDGS PLC	SHS EUR	G6518L108	34,875	2,459,480	SH		DFND	4 9	0	617,832	1,841,648
NIKE INC	CL B	654106103	1,510,609	12,032,910	SH		DFND	4 9 10	0	10,439,600	1,593,310
NIO INC	SPON ADS	62914V106	848	39,970	SH		DFND	9 10	0	39,970	0
NISOURCE INC	COM	65473P105	3,576	162,552	SH		DFND	4 9	0	162,552	0
NOMAD FOODS LTD	USD ORD SHS	G6564A105	52,070	2,043,558	SH		DFND	2	0	2,043,558	0
NORDSON CORP	COM	655663102	157,866	822,991	SH		DFND	4 9 10	0	791,519	31,472
NORFOLK SOUTHN CORP	COM	655844108	14,981	70,007	SH		DFND	4 9	0	67,236	2,771
NORTHERN TR CORP	COM	665859104	5,150	66,063	SH		DFND	4 9	0	66,063	0
NORTHROP GRUMMAN CORP	COM	666807102	24,596	77,967	SH		DFND	4 9 10	0	67,067	10,900
NORTHWESTERN CORP	COM NEW	668074305	23,695	487,150	SH		DFND	2	0	487,150	0
NORTONLIFELOCK INC	COM	668771108	39,487	1,894,880	SH		DFND	4 9	0	621,981	1,272,899
NORWEGIAN CRUISE LINE HLDG L	SHS	G66721104	662	38,690	SH		DFND	9 10	0	38,690	0
NOVANTA INC	COM	67000B104	31,977	303,561	SH		DFND	10	0	281,680	21,881
NOVARTIS AG	SPONSORED ADR	66987V109	403,469	4,639,707	SH		DFND	4 10	0	4,495,568	144,139
NOVO-NORDISK A S	ADR	670100205	16,632	239,554	SH		DFND	10	0	239,554	0
NOW INC	COM	67011P100	57	12,500	SH		DFND	4	0	12,500	0
NRG ENERGY INC	COM NEW	629377508	264,923	8,618,191	SH		DFND	4 9 10	0	7,982,486	635,705
NUCOR CORP	COM	670346105	5,607	125,026	SH		DFND	4 9 11	0	125,026	0
NUTRIEN LTD	COM	67077M108	35,753	911,360	SH		DFND	2	0	886,045	25,315
NUTRIEN LTD	COM	67077M108	95,744	2,448,024	SH		DFND	2 4 9 11	0	2,166,922	281,102
NVIDIA CORPORATION	COM	67066G104	2,349,232	4,340,804	SH		DFND	4 9 10	0	3,948,785	392,019
NVR INC	COM	62944T105	39,566	9,679	SH		DFND	4 9 10 12	0	9,424	255
NXP SEMICONDUCTORS N V	COM	N6596X109	95,141	762,731	SH		DFND	4 9 10	0	762,731	0
OAK STR HEALTH INC	COM	67181A107	21,326	399,066	SH		DFND	10	0	369,130	29,936
OCCIDENTAL PETE CORP	COM	674599105	2,378	237,603	SH		DFND	4 9	0	237,603	0
ODONATE THERAPEUTICS INC	COM	676079106	35,346	2,631,829	SH		DFND	10	0	2,549,328	82,501
OGE ENERGY CORP	COM	670837103	405	13,508	SH		DFND	4 9	0	13,508	0
OKTA INC	CL A	679295105	88,159	412,243	SH		DFND	4 9 10	0	176,509	235,734
OLD DOMINION FREIGHT LINE IN	COM	679580100	29,485	162,981	SH		DFND	4 9	0	123,985	38,996
OLD REP INTL CORP	COM	680223104	2,146	145,600	SH		DFND	9	0	66,144	79,456
OLLIES BARGAIN OUTLET HLDGS	COM	681116109	778	8,905	SH		DFND	9 10	0	8,905	0
OMEGA HEALTHCARE INVS INC	COM	681936100	2,745	91,673	SH		DFND	4 9 10	0	91,673	0
OMNICELL COM	COM	68213N109	19,045	255,084	SH		DFND	2 4	0	255,084	0
OMNICOM GROUP INC	COM	681919106	64,732	1,307,714	SH		DFND	4 9	0	572,856	734,858
ON SEMICONDUCTOR CORP	COM	682189105	457,143	21,076,198	SH		DFND	4 9 10	0	20,391,075	685,123
ONEMAIN HLDGS INC	COM	68268W103	2,420	77,425	SH		DFND	4 9	0	41,024	36,401
ONEOK INC NEW	COM	682680103	2,973	114,438	SH		DFND	4 9	0	114,438	0
OPEN TEXT CORP	COM	683715106	3,017	71,614	SH		DFND	4 9	0	71,614	0
ORACLE CORP	COM	68389X105	297,907	4,990,379	SH		DFND	2 4 9 10	0	3,917,826	1,072,553
ORCHARD THERAPEUTICS PLC	ADS	68570P101	2,781	676,753	SH		DFND	10	0	646,048	30,705
OREILLY AUTOMOTIVE INC	COM	67103H107	34,407	74,630	SH		DFND	2 4 9 10	0	74,630	0
OSI SYSTEMS INC	COM	671044105	142,535	1,836,560	SH		DFND	10	0	1,766,592	69,968
OSISKO GOLD ROYALTIES LTD	COM	68827L101	6,497	551,025	SH		DFND	11	0	551,025	0
OTIS WORLDWIDE CORP	COM	68902V107	101,124	1,620,126	SH		DFND	4 9	0	479,373	1,140,753
OUTFRONT MEDIA INC	COM	69007J106	3,312	227,638	SH		DFND	9	0	114,930	112,708
OUTSET MED INC	COM	690145107	5,383	107,651	SH		DFND	10	0	66,042	41,609
OWENS CORNING NEW	COM	690742101	1,194	17,351	SH		DFND	4 9	0	17,351	0
PACCAR INC	COM	693718108	14,230	166,852	SH		DFND	4 9	0	148,162	18,690
PACKAGING CORP AMER	COM	695156109	21,034	192,876	SH		DFND	4 9	0	130,752	62,124
PAGERDUTY INC	COM	69553P100	71,354	2,632,015	SH		DFND	10	0	2,529,944	102,071
PALO ALTO NETWORKS INC	COM	697435105	36,915	150,827	SH		DFND	4 9	0	83,241	67,586
PAN AMERN SILVER CORP	COM	697900108	6,207	193,651	SH		DFND	4 9 11	0	193,651	0
PANACEA ACQUISITION CORP	UNIT 99/99/9999	698102209	2,088	176,103	SH		DFND	10	0	176,103	0
PARKER-HANNIFIN CORP	COM	701094104	180,164	890,403	SH		DFND	4 9 10	0	861,823	28,580
PARSLEY ENERGY INC	CL A	701877102	17,427	1,861,845	SH		DFND	2 9 11	0	1,858,602	3,243
PARSONS CORPORATION	COM	70202L102	906	27,021	SH		DFND	10	0	27,021	0
PATRICK INDS INC	COM	703343103	362	6,291	SH		DFND	10	0	6,291	0
PAYCHEX INC	COM	704326107	10,760	134,893	SH		DFND	4 9	0	134,893	0
PAYCOM SOFTWARE INC	COM	70432V102	17,299	55,590	SH		DFND	4 9	0	40,893	14,697
PAYLOCITY HLDG CORP	COM	70438V106	91,622	567,602	SH		DFND	10	0	485,383	82,219
PAYPAL HLDGS INC	COM	70450Y103	734,956	3,730,541	SH		DFND	4 9 10	0	3,663,094	67,447
PEBBLEBROOK HOTEL TR	COM	70509V100	33,859	2,703,319	SH		DFND	4 10 12	0	2,628,859	74,460
PEGASYSTEMS INC	COM	705573103	6,399	52,866	SH		DFND	9	0	34,995	17,871
PELOTON INTERACTIVE INC	CL A COM	70614W100	23,113	232,905	SH		DFND	4 9 10	0	227,386	5,519
PEMBINA PIPELINE CORP	COM	706327103	2,929	138,466	SH		DFND	4 9	0	138,448	18
PENN NATL GAMING INC	COM	707569109	3,632	50,000	SH		DFND	4	0	50,000	0
PENNANT GROUP INC	COM	70805E109	231	5,988	SH		DFND	10	0	5,988	0
PENNYMAC FINL SVCS INC NEW	COM	70932M107	267	4,586	SH		DFND	10	0	4,586	0
PENTAIR PLC	SHS	G7S00T104	2,879	62,911	SH		DFND	4 9	0	62,911	0
PENUMBRA INC	COM	70975L107	1,791	9,216	SH		DFND	10	0	9,216	0
PEOPLES UNITED FINANCIAL INC	COM	712704105	715	69,347	SH		DFND	4 9	0	69,347	0
PEPSICO INC	COM	713448108	164,333	1,186,290	SH		DFND	2 4 9 10	0	604,706	581,584
PERKINELMER INC	COM	714046109	473,188	3,770,126	SH		DFND	4 9 10	0	3,652,746	117,380
PERRIGO CO PLC	SHS	G97822103	2,291	49,920	SH		DFND	4 9	0	49,107	813
PFIZER INC	COM	717081103	185,504	5,056,099	SH		DFND	2 4 9 10	0	4,711,134	344,965
PG&E CORP	COM	69331C108	327	34,833	SH		DFND	4 9	0	31,976	2,857
PGT INNOVATIONS INC	COM	69336V101	20,667	1,179,651	SH		DFND	2 10	0	1,179,651	0
PHATHOM PHARMACEUTICALS INC	COM	71722W107	57,538	1,568,796	SH		DFND	10	0	1,512,018	56,778
PHIBRO ANIMAL HEALTH CORP	CL A COM	71742Q106	12,877	740,085	SH		DFND	2	0	740,085	0
PHILIP MORRIS INTL INC	COM	718172109	34,844	464,691	SH		DFND	4 9 10	0	366,230	98,461
PHILLIPS 66	COM	718546104	29,006	559,550	SH		DFND	4 9	0	97,387	462,163
PHREESIA INC	COM	71944F106	7,323	227,923	SH		DFND	10	0	217,847	10,076
PHYSICIANS RLTY TR	COM	71943U104	24,392	1,363,063	SH		DFND	4 10	0	1,363,063	0
PINDUODUO INC	SPONSORED ADS	722304102	28,636	386,184	SH		DFND	9	0	59,611	326,573
PINNACLE FINL PARTNERS INC	COM	72346Q104	860	24,164	SH		DFND	2	0	24,164	0
PINNACLE WEST CAP CORP	COM	723484101	21,507	288,489	SH		DFND	4 9	0	271,624	16,865
PINTEREST INC	CL A	72352L106	45,293	1,091,524	SH		DFND	4 9	0	1,091,524	0
PIONEER NAT RES CO	COM	723787107	22,370	260,146	SH		DFND	2 4 9	0	260,146	0
PLANET FITNESS INC	CL A	72703H101	369	5,984	SH		DFND	10	0	5,984	0
PMV PHARMACEUTICALS INC	COM	69353Y103	12,841	361,724	SH		DFND	10	0	342,738	18,986
PNC FINL SVCS GROUP INC	COM	693475105	16,421	149,423	SH		DFND	2 4 9	0	137,315	12,108
POLARIS INC	COM	731068102	694	7,355	SH		DFND	4	0	7,355	0
POOL CORP	COM	73278L105	5,447	16,281	SH		DFND	9 10	0	16,218	63
POPULAR INC	COM NEW	733174700	2,698	74,395	SH		DFND	9	0	33,409	40,986
PPD INC	COM	69355F102	2,774	75,000	SH		DFND	4	0	75,000	0
PPG INDS INC	COM	693506107	8,927	73,127	SH		DFND	4 9	0	72,672	455
PPL CORP	COM	69351T106	14,257	523,974	SH		DFND	2 4 9 10	0	385,624	138,350
PQ GROUP HLDGS INC	COM	73943T103	3,255	317,287	SH		DFND	10	0	317,287	0
PRA HEALTH SCIENCES INC	COM	69354M108	242,664	2,392,187	SH		DFND	10	0	2,330,190	61,997
PRESTIGE CONSMR HEALTHCARE I	COM	74112D101	24,404	670,070	SH		DFND	10	0	640,957	29,113
PRETIUM RES INC	COM	74139C102	409	32,026	SH		DFND	11	0	32,026	0
PRICE T ROWE GROUP INC	COM	74144T108	106,526	830,824	SH		DFND	4 9	0	307,078	523,746
PRINCIPAL FINANCIAL GROUP IN	COM	74251V102	3,130	77,741	SH		DFND	4 9	0	77,741	0
PROCTER AND GAMBLE CO	COM	742718109	1,793,625	12,904,959	SH		DFND	2 4 9 10	0	11,225,088	1,679,871
PROGRESSIVE CORP	COM	743315103	1,072,315	11,326,912	SH		DFND	4 9 10	0	9,656,633	1,670,279
PROLOGIS INC.	COM	74340W103	163,086	1,620,949	SH		DFND	4 9 10 12	0	1,520,459	100,490
PROOFPOINT INC	COM	743424103	52,226	494,725	SH		DFND	4	0	494,725	0
PROSPERITY BANCSHARES INC	COM	743606105	54,079	1,043,390	SH		DFND	2 9	0	1,043,390	0
PROTO LABS INC	COM	743713109	908	7,011	SH		DFND	10	0	7,011	0
PROVIDENCE SVC CORP	COM	743815102	1,282	13,800	SH		DFND	10	0	13,190	610
PRUDENTIAL FINL INC	COM	744320102	6,398	100,741	SH		DFND	4 9	0	100,741	0
PTC INC	COM	69370C100	1,820	22,014	SH		DFND	4 9	0	22,014	0
PTC THERAPEUTICS INC	COM	69366J200	94,367	2,018,563	SH		DFND	10	0	1,947,816	70,747
PUBLIC STORAGE	COM	74460D109	150,321	674,942	SH		DFND	2 4 9	0	512,936	162,006
PUBLIC SVC ENTERPRISE GRP IN	COM	744573106	8,510	154,982	SH		DFND	4 9	0	154,982	0
PULTE GROUP INC	COM	745867101	76,224	1,646,662	SH		DFND	4 9 10	0	1,561,359	85,303
QIAGEN NV	SHS NEW	N72482123	28,696	552,511	SH		DFND	4 9	0	64,136	488,375
QIAGEN NV	SHS NEW	N72482123	6,860	131,275	SH		DFND	9	0	116,939	14,336
QORVO INC	COM	74736K101	138,658	1,075,480	SH		DFND	4 9	0	969,250	106,230
QUALCOMM INC	COM	747525103	639,473	5,434,063	SH		DFND	4 9 10	0	3,527,426	1,906,637
QUALYS INC	COM	74758T303	1,275	13,011	SH		DFND	10	0	13,011	0
QUEST DIAGNOSTICS INC	COM	74834L100	152,674	1,333,518	SH		DFND	2 4 9 10	0	1,031,870	301,648
QUIDEL CORP	COM	74838J101	61,589	280,743	SH		DFND	9 10	0	266,962	13,781
QURATE RETAIL INC	COM SER A	74915M100	10,428	1,452,385	SH		DFND	2	0	1,452,385	0
RALPH LAUREN CORP	CL A	751212101	11,300	166,253	SH		DFND	4 9	0	158,998	7,255
RAYMOND JAMES FINL INC	COM	754730109	2,553	35,093	SH		DFND	4 9	0	35,093	0
RAYTHEON TECHNOLOGIES CORP	COM	75513E101	127,126	2,209,433	SH		DFND	2 4 9	0	1,253,457	955,976
RBC BEARINGS INC	COM	75524B104	341	2,813	SH		DFND	10	0	2,813	0
REALPAGE INC	COM	75606N109	195,699	3,395,193	SH		DFND	10	0	3,121,951	273,242
REALTY INCOME CORP	COM	756109104	24,143	397,447	SH		DFND	4 9	0	311,899	85,548
REDBALL ACQUISITION CORP	UNIT 99/99/9999	G7417R121	21,141	2,000,100	SH		DFND	10	0	2,000,100	0
REDBALL ACQUISITION CORP	UNIT 99/99/9999	G7417R121	25	2,339	SH		DFND	10	0	2,339	0
REDBALL ACQUISITION CORP	UNIT 99/99/9999	G7417R121	21,166	2,002,439	SH		DFND	10	0	2,002,439	0
REDFIN CORP	COM	75737F108	57,074	1,143,079	SH		DFND	10	0	1,090,091	52,988
REGENCY CTRS CORP	COM	758849103	1,536	40,403	SH		DFND	4 9	0	40,403	0
REGENERON PHARMACEUTICALS	COM	75886F107	191,208	341,587	SH		DFND	4 9 10	0	211,063	130,524
REGIONS FINANCIAL CORP NEW	COM	7591EP100	39,483	3,424,453	SH		DFND	2 4 9	0	3,424,453	0
REINSURANCE GRP OF AMERICA I	COM NEW	759351604	23,524	247,122	SH		DFND	4 9	0	19,451	227,671
RELAY THERAPEUTICS INC	COM	75943R102	20,726	486,611	SH		DFND	10	0	407,459	79,152
RELIANCE STEEL & ALUMINUM CO	COM	759509102	3,722	36,477	SH		DFND	4 9	0	21,281	15,196
RENAISSANCERE HLDGS LTD	COM	G7496G103	130,269	767,462	SH		DFND	2 4 9	0	694,520	72,942
REPAY HLDGS CORP	COM CL A	76029L100	22,606	961,985	SH		DFND	4 10	0	924,804	37,181
REPLIGEN CORP	COM	759916109	3,385	22,942	SH		DFND	9	0	19,943	2,999
REPUBLIC SVCS INC	COM	760759100	47,163	505,234	SH		DFND	2 4 9	0	460,226	45,008
RESMED INC	COM	761152107	253,318	1,477,691	SH		DFND	4 9	0	513,107	964,584
RESTAURANT BRANDS INTL INC	COM	76131D103	3,560	62,142	SH		DFND	4 9	0	62,142	0
RETROPHIN INC	COM	761299106	67,510	3,657,157	SH		DFND	10	0	3,526,007	131,150
REXFORD INDL RLTY INC	COM	76169C100	51,648	1,129,415	SH		DFND	4 9 10 12	0	1,097,565	31,850
REXNORD CORP	COM	76169B102	336,032	11,261,129	SH		DFND	10	0	10,867,169	393,960
REYNOLDS CONSUMER PRODS INC	COM	76171L106	44,446	1,451,529	SH		DFND	10	0	1,451,529	0
RHYTHM PHARMACEUTICALS INC	COM	76243J105	95,053	4,386,370	SH		DFND	10	0	4,242,577	143,793
RINGCENTRAL INC	CL A	76680R206	282,466	1,028,614	SH		DFND	4 9 10	0	781,339	247,275
RITCHIE BROS AUCTIONEERS	COM	767744105	118	2,004	SH		DFND	4 9	0	2,004	0
RITCHIE BROS AUCTIONEERS	COM	767744105	370,079	6,246,065	SH		DFND	10	0	6,040,403	205,662
RLI CORP	COM	749607107	35,675	426,073	SH		DFND	10	0	399,952	26,121
ROBERT HALF INTL INC	COM	770323103	8,380	158,289	SH		DFND	4 9	0	39,723	118,566
ROCKET PHARMACEUTICALS INC	COM	77313F106	1,789	78,267	SH		DFND	10	0	78,267	0
ROCKWELL AUTOMATION INC	COM	773903109	116,837	529,430	SH		DFND	4 9 10	0	405,283	124,147
ROGERS COMMUNICATIONS INC	CL B	775109200	33,866	856,405	SH		DFND	2 4 9	0	154,239	702,166
ROGERS CORP	COM	775133101	76,323	778,330	SH		DFND	2 10	0	753,800	24,530
ROKU INC	COM CL A	77543R102	32,219	170,652	SH		DFND	4 9 10	0	114,977	55,675
ROLLINS INC	COM	775711104	26,235	484,139	SH		DFND	4 9 10	0	282,218	201,921
ROPER TECHNOLOGIES INC	COM	776696106	94,966	240,279	SH		DFND	4 9	0	219,825	20,454
ROSS STORES INC	COM	778296103	34,344	368,014	SH		DFND	2 4 9	0	363,306	4,708
ROYAL BK CDA	COM	780087102	58,612	837,400	SH		DFND	4 9	0	500,347	337,053
ROYAL CARIBBEAN GROUP	COM	V7780T103	29,151	450,362	SH		DFND	4 9	0	411,648	38,714
ROYAL GOLD INC	COM	780287108	707	5,880	SH		DFND	9	0	5,880	0
ROYALTY PHARMA PLC	SHS CL A	G7709Q104	198,766	4,724,644	SH		DFND	10	0	4,566,619	158,025
RPM INTL INC	COM	749685103	21,067	254,307	SH		DFND	4 9	0	153,645	100,662
RYANAIR HOLDINGS PLC	SPONSORED ADS	783513203	238,525	2,917,375	SH		DFND	10	0	2,818,809	98,566
S&P GLOBAL INC	COM	78409V104	208,459	578,138	SH		DFND	4 9 10	0	578,138	0
SABRA HEALTH CARE REIT INC	COM	78573L106	28,472	2,065,454	SH		DFND	4 10 12	0	2,007,993	57,461
SABRE CORP	COM	78573M104	2,397	367,888	SH		DFND	4 9	0	364,310	3,578
SAFEGUARD SCIENTIFICS INC	COM NEW	786449207	1,708	310,246	SH		DFND	4 10	0	310,246	0
SAFEHOLD INC	COM	78645L100	710	11,436	SH		DFND	10	0	11,436	0
SAGE THERAPEUTICS INC	COM	78667J108	98,995	1,619,701	SH		DFND	10	0	1,569,678	50,023
SAIA INC	COM	78709Y105	147,309	1,167,822	SH		DFND	10	0	1,127,366	40,456
SAILPOINT TECHNLGIES HLDGS I	COM	78781P105	99,899	2,524,619	SH		DFND	10	0	2,002,257	522,362
SALESFORCE COM INC	COM	79466L302	2,599,352	10,344,339	SH		DFND	4 9 10	0	9,452,775	891,564
SANDERSON FARMS INC	COM	800013104	54,741	464,026	SH		DFND	2	0	464,026	0
SANOFI	SPONSORED ADR	80105N105	26,571	529,604	SH		DFND	4 10	0	529,604	0
SANTANDER CONSUMER USA HDG I	COM	80283M101	1,799	98,923	SH		DFND	9	0	93,069	5,854
SAREPTA THERAPEUTICS INC	COM	803607100	554,781	3,950,552	SH		DFND	4 9 10	0	3,833,989	116,563
SBA COMMUNICATIONS CORP NEW	CL A	78410G104	69,844	219,417	SH		DFND	4 9 10 12	0	193,741	25,676
SCHLUMBERGER LTD	COM	806857108	11,204	720,202	SH		DFND	2 4 9 11	0	720,202	0
SCHWAB CHARLES CORP	COM	808513105	19,016	524,908	SH		DFND	2 4 9	0	476,118	48,790
SCOTTS MIRACLE GRO CO	CL A	810186106	10,740	70,239	SH		DFND	4 9	0	46,356	23,883
SEAGATE TECHNOLOGY PLC	SHS	G7945M107	110,617	2,245,119	SH		DFND	4 9	0	707,656	1,537,463
SEALED AIR CORP NEW	COM	81211K100	359,205	9,255,478	SH		DFND	4 9 10	0	8,996,879	258,599
SEATTLE GENETICS INC	COM	812578102	109,154	557,785	SH		DFND	4 9 10	0	161,599	396,186
SEI INVTS CO	COM	784117103	1,965	38,760	SH		DFND	4 9	0	38,329	431
SELECT SECTOR SPDR TR	SBI INT-FINL	81369Y605	285	488,800	SH	Call	DFND	10	0	4,888	0
SELECT SECTOR SPDR TR	SBI INT-FINL	81369Y605	1,873	77,822	SH		DFND	10	0	77,822	0
SELECT SECTOR SPDR TR	SBI INT-FINL	81369Y605	3	4,600	SH	Call	DFND	10	0	46	0
SELECT SECTOR SPDR TR	SBI INT-INDS	81369Y704	802	10,419	SH		DFND	10	0	10,419	0
SELECT SECTOR SPDR TR	SBI INT-FINL	81369Y605	288	493,400	SH	Call	DFND	10	0	4,934	0
SELECT SECTOR SPDR TR	TECHNOLOGY	81369Y803	5,616	48,126	SH		DFND	10	0	48,126	0
SELECTIVE INS GROUP INC	COM	816300107	58,691	1,139,847	SH		DFND	10	0	1,111,432	28,415
SELECTQUOTE INC	COM	816307300	208	10,252	SH		DFND	10	0	10,252	0
SEMPRA ENERGY	COM	816851109	332,024	2,805,220	SH		DFND	4 9 10	0	2,777,026	28,194
SENSATA TECHNOLOGIES HLDNG P	SHS	G8060N102	432,083	10,015,731	SH		DFND	4 9 10	0	9,703,131	312,600
SENSIENT TECHNOLOGIES CORP	COM	81725T100	233,896	4,050,841	SH		DFND	10	0	3,893,138	157,703
SERES THERAPEUTICS INC	COM	81750R102	54,185	1,914,077	SH		DFND	10	0	1,844,854	69,223
SERVICEMASTER GLOBAL HLDGS I	COM	81761R109	784,363	19,668,083	SH		DFND	9 10	0	19,139,745	528,338
SERVICENOW INC	COM	81762P102	178,510	368,187	SH		DFND	4 9 10	0	367,455	732
SHAKE SHACK INC	CL A	819047101	429	6,649	SH		DFND	10	0	6,649	0
SHAW COMMUNICATIONS INC	CL B CONV	82028K200	51,274	2,818,550	SH		DFND	4 9	0	776,429	2,042,121
SHERWIN WILLIAMS CO	COM	824348106	789,408	1,133,012	SH		DFND	4 9 10	0	1,099,255	33,757
SHIFT4 PMTS INC	CL A	82452J109	5,513	114,005	SH		DFND	10	0	109,082	4,923
SHOPIFY INC	CL A	82509L107	24,206	23,763	SH		DFND	4 9	0	23,763	0
SHOTSPOTTER INC	COM	82536T107	870	28,037	SH		DFND	10	0	28,037	0
SHUTTERSTOCK INC	COM	825690100	19,637	377,343	SH		DFND	2	0	377,343	0
SIGNATURE BK NEW YORK N Y	COM	82669G104	681	8,204	SH		DFND	4 9	0	8,204	0
SILK RD MED INC	COM	82710M100	69,445	1,033,251	SH		DFND	10	0	1,000,541	32,710
SIMON PPTY GROUP INC NEW	COM	828806109	4,635	71,679	SH		DFND	4 9	0	71,679	0
SIMPLY GOOD FOODS CO	COM	82900L102	78,848	3,575,884	SH		DFND	10	0	3,442,983	132,901
SIMPSON MANUFACTURING CO INC	COM	829073105	474	4,878	SH		DFND	10	0	4,878	0
SIRIUS XM HOLDINGS INC	COM	82968B103	3,690	688,638	SH		DFND	4 9 10	0	688,638	0
SITEONE LANDSCAPE SUPPLY INC	COM	82982L103	604	4,954	SH		DFND	10	0	4,954	0
SK TELECOM LTD	SPONSORED ADR	78440P108	33,627	1,500,550	SH		DFND	4 12	0	1,500,550	0
SKECHERS U S A INC	CL A	830566105	388	12,828	SH		DFND	4 10	0	12,828	0
SKYLINE CHAMPION CORPORATION	COM	830830105	12,330	460,581	SH		DFND	2 10	0	460,581	0
SKYWORKS SOLUTIONS INC	COM	83088M102	21,496	147,738	SH		DFND	4 9	0	140,236	7,502
SL GREEN RLTY CORP	COM	78440X101	28,233	609,000	SH		DFND	4 10 12	0	591,373	17,627
SLACK TECHNOLOGIES INC	COM CL A	83088V102	1,729	64,374	SH		DFND	4 9	0	64,374	0
SMARTSHEET INC	COM CL A	83200N103	1,530	30,956	SH		DFND	9	0	21,379	9,577
SMITH A O CORP	COM	831865209	7,212	136,600	SH		DFND	4 9	0	36,788	99,812
SMUCKER J M CO	COM NEW	832696405	60,059	519,898	SH		DFND	2 4 9 10	0	293,997	225,901
SNAP INC	CL A	83304A106	467,726	17,913,732	SH		DFND	4 9 10	0	16,426,940	1,486,792
SNAP ON INC	COM	833034101	39,407	267,840	SH		DFND	4 9	0	51,304	216,536
SNOWFLAKE INC	CL A	833445109	5,648	22,504	SH		DFND	10	0	19,619	2,885
SONOCO PRODS CO	COM	835495102	65,546	1,283,447	SH		DFND	2 9	0	1,211,995	71,452
SONY CORP	SPONSORED ADR	835699307	279	3,631	SH		DFND	10	0	3,631	0
SOUTHERN CO	COM	842587107	147,142	2,713,813	SH		DFND	4 9	0	1,723,196	990,617
SOUTHERN COPPER CORP	COM	84265V105	1,183	26,128	SH		DFND	4 9	0	26,128	0
SOUTHWEST AIRLS CO	COM	844741108	2,125	56,680	SH		DFND	4 9 10	0	56,149	531
SOUTHWEST GAS HOLDINGS INC	COM	844895102	92,657	1,468,416	SH		DFND	2	0	1,468,416	0
SPDR S&P 500 ETF TR	TR UNIT	78462F103	171	13,900	SH	Call	DFND	10	0	139	0
SPDR S&P 500 ETF TR	TR UNIT	78462F103	4	2,000	SH	Call	DFND	10	0	20	0
SPDR S&P 500 ETF TR	TR UNIT	78462F103	32	3,300	SH	Put	DFND	10	0	33	0
SPDR S&P 500 ETF TR	TR UNIT	78462F103	42	4,000	SH	Put	DFND	10	0	40	0
SPDR S&P 500 ETF TR	TR UNIT	78462F103	175	15,900	SH	Call	DFND	10	0	159	0
SPDR S&P 500 ETF TR	TR UNIT	78462F103	10	700	SH	Put	DFND	10	0	7	0
SPDR SER TR	S&P HOMEBUILD	78464A888	1,386	25,722	SH		DFND	10	0	25,722	0
SPECTRUM BRANDS HLDGS INC NE	COM	84790A105	3,517	61,528	SH		DFND	4 9	0	21,655	39,873
SPIRIT RLTY CAP INC NEW	COM NEW	84860W300	36,475	1,080,887	SH		DFND	4 9 10 12	0	989,975	90,912
SPLUNK INC	COM	848637104	172,731	918,053	SH		DFND	4 9 10	0	530,755	387,298
SPOTIFY TECHNOLOGY S A	SHS	L8681T102	8,284	34,154	SH		DFND	4 9	0	27,378	6,776
SPS COMMERCE INC	COM	78463M107	2,482	31,876	SH		DFND	10	0	31,876	0
SPX CORP	COM	784635104	2,760	59,515	SH		DFND	4 10	0	56,924	2,591
SQUARE INC	CL A	852234103	13,446	82,666	SH		DFND	4 9	0	82,666	0
SS&C TECHNOLOGIES HLDGS INC	COM	78467J100	1,118,227	18,476,205	SH		DFND	4 9 10	0	18,001,602	474,603
SSR MNG INC	COM	784730103	6,364	341,551	SH		DFND	11	0	341,551	0
STAG INDL INC	COM	85254J102	97,382	3,193,893	SH		DFND	2 10	0	3,193,893	0
STANDEX INTL CORP	COM	854231107	20,317	343,190	SH		DFND	10	0	328,452	14,738
STANLEY BLACK & DECKER INC	COM	854502101	56,257	346,844	SH		DFND	4 9 10	0	346,844	0
STARBUCKS CORP	COM	855244109	342,195	3,982,829	SH		DFND	2 4 9 10	0	3,829,185	153,644
STATE STR CORP	COM	857477103	8,446	142,367	SH		DFND	4 9	0	141,466	901
STEEL DYNAMICS INC	COM	858119100	1,311	45,783	SH		DFND	4 9	0	45,783	0
STERIS PLC	SHS USD	G8473T100	715,548	4,061,229	SH		DFND	4 9 10	0	3,916,752	144,477
STERLING BANCORP DEL	COM	85917A100	130	12,322	SH		DFND	10	0	12,322	0
STITCH FIX INC	COM CL A	860897107	269	9,914	SH		DFND	10	0	9,914	0
STONERIDGE INC	COM	86183P102	32,577	1,773,364	SH		DFND	2	0	1,773,364	0
STORE CAP CORP	COM	862121100	232	8,467	SH		DFND	10	0	8,467	0
STRYKER CORPORATION	COM	863667101	257,737	1,236,946	SH		DFND	2 4 9 10	0	1,223,728	13,218
SUMMIT MATLS INC	CL A	86614U100	96,451	5,831,391	SH		DFND	10	0	5,724,152	107,239
SUN CMNTYS INC	COM	866674104	77,705	552,364	SH		DFND	4 9 10 12	0	540,427	11,937
SUN LIFE FINANCIAL INC.	COM	866796105	21,345	525,417	SH		DFND	4 9	0	227,171	298,246
SUNCOR ENERGY INC NEW	COM	867224107	20,148	1,655,257	SH		DFND	4 9 10	0	1,563,057	92,200
SUNSTONE HOTEL INVS INC NEW	COM	867892101	51,507	6,487,083	SH		DFND	2	0	6,487,083	0
SUPERNUS PHARMACEUTICALS INC	COM	868459108	1,399	67,127	SH		DFND	10	0	67,127	0
SURMODICS INC	COM	868873100	17,403	447,264	SH		DFND	10	0	411,606	35,658
SUTRO BIOPHARMA INC	COM	869367102	1,566	156,017	SH		DFND	10	0	156,017	0
SVB FINANCIAL GROUP	COM	78486Q101	166,295	691,113	SH		DFND	4 9 10	0	669,017	22,096
SYNCHRONY FINANCIAL	COM	87165B103	133,470	5,100,190	SH		DFND	2 4 9 10	0	2,310,266	2,789,924
SYNEOS HEALTH INC	CL A	87166B102	1,415	26,618	SH		DFND	10	0	26,618	0
SYNNEX CORP	COM	87162W100	2,391	17,072	SH		DFND	10	0	17,072	0
SYNOPSYS INC	COM	871607107	166,842	779,720	SH		DFND	2 4 9	0	572,282	207,438
SYSCO CORP	COM	871829107	393,843	6,329,875	SH		DFND	4 9 10	0	3,254,505	3,075,370
TACTILE SYS TECHNOLOGY INC	COM	87357P100	905	24,744	SH		DFND	10	0	24,744	0
TAIWAN SEMICONDUCTOR MFG LTD	SPONSORED ADS	874039100	485,381	5,986,493	SH		DFND	4 10 12	0	5,700,597	285,896
TAKEDA PHARMACEUTICAL CO LTD	SPONSORED ADS	874060205	12,509	701,149	SH		DFND	10	0	701,149	0
TAKE-TWO INTERACTIVE SOFTWAR	COM	874054109	231,495	1,401,141	SH		DFND	4 9	0	651,984	749,157
TAL EDUCATION GROUP	SPONSORED ADS	874080104	16,112	211,884	SH		DFND	9	0	41,357	170,527
TAPESTRY INC	COM	876030107	10,895	697,025	SH		DFND	9	0	642,119	54,906
TARGET CORP	COM	87612E106	397,991	2,528,241	SH		DFND	4 9 10	0	1,701,514	826,727
TC ENERGY CORP	COM	87807B107	9,227	220,265	SH		DFND	4 9	0	220,265	0
TD AMERITRADE HLDG CORP	COM	87236Y108	158,791	4,055,962	SH		DFND	4 9 10	0	3,911,000	144,962
TE CONNECTIVITY LTD	REG SHS	H84989104	664,826	6,802,040	SH		DFND	4 9 10	0	6,607,436	194,604
TECK RESOURCES LTD	CL B	878742204	110,549	7,964,492	SH		DFND	4 9 10 11	0	7,897,224	67,268
TELADOC HEALTH INC	COM	87918A105	29,858	136,192	SH		DFND	4 9 10	0	47,139	89,053
TELECOM ARGENTINA S A	SPON ADR REP B	879273209	272	41,586	SH		DFND	9	0	41,586	0
TELEDYNE TECHNOLOGIES INC	COM	879360105	403,176	1,299,694	SH		DFND	4 9 10	0	1,264,832	34,862
TELEFLEX INCORPORATED	COM	879369106	283,169	831,826	SH		DFND	4 9 10	0	806,187	25,639
TELEPHONE & DATA SYS INC	COM NEW	879433829	2,829	153,396	SH		DFND	9	0	69,898	83,498
TELUS CORPORATION	COM	87971M103	2	120	SH		DFND	4	0	120	0
TELUS CORPORATION	COM	87971M103	21,741	1,237,335	SH		DFND	4	0	1,189,011	48,324
TELUS CORPORATION	COM	87971M103	21,743	1,237,455	SH		DFND	4	0	1,189,131	48,324
TERADYNE INC	COM	880770102	2,627	33,067	SH		DFND	4 9	0	33,067	0
TESLA INC	COM	88160R101	1,230	15,200	SH	Put	DFND	10	0	152	0
TESLA INC	COM	88160R101	213,357	497,369	SH		DFND	4 9 10	0	413,262	84,107
TEVA PHARMACEUTICAL INDS LTD	SPONSORED ADS	881624209	2,021	224,391	SH		DFND	4 9	0	220,898	3,493
TEXAS INSTRS INC	COM	882508104	1,852,530	12,974,212	SH		DFND	2 4 9 10	0	11,689,150	1,285,062
TEXAS ROADHOUSE INC	COM	882681109	316	5,191	SH		DFND	10	0	5,191	0
TEXTRON INC	COM	883203101	807	22,368	SH		DFND	4 9	0	22,158	210
THE TRADE DESK INC	COM CL A	88339J105	149,359	287,909	SH		DFND	4 9 10	0	254,600	33,309
THERAPEUTICS ACQUISITION COR	COM CL A	88339T103	1,790	124,666	SH		DFND	10	0	124,666	0
THERMO FISHER SCIENTIFIC INC	COM	883556102	1,144,126	2,591,494	SH		DFND	4 9 10	0	2,539,875	51,619
THERMON GROUP HLDGS INC	COM	88362T103	21,716	1,933,722	SH		DFND	2	0	1,933,722	0
THOMSON REUTERS CORP.	COM NEW	884903709	9,726	122,288	SH		DFND	4 9	0	117,948	4,340
THOR INDS INC	COM	885160101	79,259	832,023	SH		DFND	10	0	799,505	32,518
TIFFANY & CO NEW	COM	886547108	73,455	634,056	SH		DFND	4 9	0	245,566	388,490
TJX COS INC NEW	COM	872540109	37,179	668,142	SH		DFND	4 9	0	653,181	14,961
T-MOBILE US INC	COM	872590104	1,098,811	9,608,411	SH		DFND	4 9 10	0	9,103,070	505,341
TOLL BROTHERS INC	COM	889478103	520	10,692	SH		DFND	4 10	0	10,692	0
TOPBUILD CORP	COM	89055F103	422	2,474	SH		DFND	10	0	2,474	0
TORO CO	COM	891092108	12,537	149,342	SH		DFND	9	0	101,832	47,510
TORONTO DOMINION BK ONT	COM NEW	891160509	76,356	1,654,236	SH		DFND	4 9 10	0	655,845	998,391
TRACTOR SUPPLY CO	COM	892356106	8,859	61,812	SH		DFND	4 9	0	61,609	203
TRADEWEB MKTS INC	CL A	892672106	742	12,788	SH		DFND	4 9	0	12,788	0
TRANE TECHNOLOGIES PLC	SHS	G8994E103	78,581	648,078	SH		DFND	4 9 10	0	564,393	83,685
TRANSDIGM GROUP INC	COM	893641100	116,481	245,154	SH		DFND	4 9	0	180,146	65,008
TRANSUNION	COM	89400J107	39,228	466,278	SH		DFND	4 9	0	91,831	374,447
TRAVELERS COMPANIES INC	COM	89417E109	132,488	1,224,631	SH		DFND	4 9 10	0	1,212,873	11,758
TREX CO INC	COM	89531P105	930	12,988	SH		DFND	10	0	12,988	0
TRI POINTE GROUP INC	COM	87265H109	305	16,789	SH		DFND	10	0	16,789	0
TRIMBLE INC	COM	896239100	74,357	1,527,905	SH		DFND	4 9	0	1,527,420	485
TRINET GROUP INC	COM	896288107	47,973	808,715	SH		DFND	4 10	0	782,767	25,948
TRIP COM GROUP LTD	ADS	89677Q107	267	8,572	SH		DFND	9	0	8,572	0
TRUIST FINL CORP	COM	89832Q109	21,823	573,575	SH		DFND	2 4 9 10	0	470,174	103,401
TURQUOISE HILL RES LTD	COM	900435108	232	274,148	SH		DFND	11	0	274,148	0
TWILIO INC	CL A	90138F102	145,980	590,804	SH		DFND	4 9 10	0	325,267	265,537
TWITTER INC	COM	90184L102	51,167	1,149,827	SH		DFND	4 9	0	998,472	151,355
TWITTER INC	NOTE 0.250% 6/1	90184LAF9	6,715	6,006,000	SH		DFND	4	0	6,006,000	0
TYLER TECHNOLOGIES INC	COM	902252105	270,727	776,709	SH		DFND	4 9 10	0	655,021	121,688
TYSON FOODS INC	CL A	902494103	39,525	664,516	SH		DFND	2 4 9	0	651,304	13,212
U S PHYSICAL THERAPY INC	COM	90337L108	1,137	13,092	SH		DFND	10	0	13,092	0
UBER TECHNOLOGIES INC	COM	90353T100	253,116	6,939,110	SH		DFND	4 9 10	0	6,638,195	300,915
UBIQUITI INC	COM	90353W103	4,696	28,176	SH		DFND	9 10	0	28,111	65
UBS GROUP AG	SHS	H42097107	104,858	9,354,621	SH		DFND	4 9	0	7,334,789	2,019,832
UBS GROUP AG	SHS	H42097107	3	266	SH		DFND	4	0	266	0
UDR INC	COM	902653104	46,302	1,420,075	SH		DFND	4 9 10 12	0	1,361,820	58,255
UFP INDUSTRIES INC	COM	90278Q108	927	16,409	SH		DFND	10	0	16,409	0
UFP TECHNOLOGIES INC	COM	902673102	319	7,700	SH		DFND	10	0	7,700	0
UGI CORP NEW	COM	902681105	1,071	32,484	SH		DFND	4 9	0	32,484	0
ULTA BEAUTY INC	COM	90384S303	10,685	47,712	SH		DFND	4 9	0	38,189	9,523
UNDER ARMOUR INC	CL C	904311206	86,274	8,767,686	SH		DFND	9 10	0	8,741,406	26,280
UNIFIRST CORP MASS	COM	904708104	100,031	528,228	SH		DFND	2	0	528,228	0
UNILEVER N V	N Y SHS NEW	904784709	372	6,153	SH		DFND	4	0	6,153	0
UNION PAC CORP	COM	907818108	196,922	1,000,392	SH		DFND	2 4 9 10	0	938,590	61,802
UNIQURE NV	SHS	N90064101	25,851	701,901	SH		DFND	10	0	685,829	16,072
UNITED AIRLS HLDGS INC	COM	910047109	1,108	31,886	SH		DFND	4 9	0	31,886	0
UNITED BANKSHARES INC WEST V	COM	909907107	54,066	2,518,233	SH		DFND	2	0	2,518,233	0
UNITED CMNTY BKS BLAIRSVLE G	COM	90984P303	58,047	3,428,643	SH		DFND	2	0	3,428,643	0
UNITED PARCEL SERVICE INC	CL B	911312106	801,888	4,812,367	SH		DFND	2 4 9 10	0	4,068,785	743,582
UNITED RENTALS INC	COM	911363109	3,959	22,697	SH		DFND	4 9	0	22,697	0
UNITED THERAPEUTICS CORP DEL	COM	91307C102	2,732	27,052	SH		DFND	9	0	21,146	5,906
UNITEDHEALTH GROUP INC	COM	91324P102	1,506,930	4,833,630	SH		DFND	4 9 10	0	4,703,715	129,915
UNITY SOFTWARE INC	COM	91332U101	31,068	355,958	SH		DFND	10	0	240,141	115,817
UNIVAR SOLUTIONS USA INC	COM	91336L107	16,049	951,062	SH		DFND	4 9	0	950,571	491
UNIVERSAL DISPLAY CORP	COM	91347P105	72,374	400,304	SH		DFND	4 10	0	400,304	0
UNIVERSAL HLTH SVCS INC	CL B	913903100	1,698	15,869	SH		DFND	4 9	0	15,603	266
UNUM THERAPEUTICS INC	COM	903214104	715	310,359	SH		DFND	10	0	310,359	0
US BANCORP DEL	COM NEW	902973304	17,906	499,702	SH		DFND	2 4 9 10	0	454,515	45,187
V F CORP	COM	918204108	147,106	2,094,037	SH		DFND	4 9 10	0	1,544,484	549,553
VAIL RESORTS INC	COM	91879Q109	66,409	310,369	SH		DFND	4 9 10	0	96,260	214,109
VALERO ENERGY CORP	COM	91913Y100	39,276	906,665	SH		DFND	2 4 9 11	0	262,541	644,124
VALVOLINE INC	COM	92047W101	43,807	2,300,802	SH		DFND	9 10	0	2,195,442	105,360
VANDA PHARMACEUTICALS INC	COM	921659108	673	69,660	SH		DFND	10	0	69,660	0
VANGUARD CHARLOTTE FDS	INTL BD IDX ETF	92203J407	1,008	17,330	SH		DFND	10	0	17,330	0
VANGUARD INDEX FDS	S&P 500 ETF SHS	922908363	92,994	302,273	SH		DFND	10	0	302,273	0
VANGUARD INDEX FDS	SMALL CP ETF	922908751	32,697	212,591	SH		DFND	10	0	212,591	0
VANGUARD INTL EQUITY INDEX F	FTSE PACIFIC ETF	922042866	1,503	22,087	SH		DFND	10	0	22,087	0
VANGUARD INTL EQUITY INDEX F	ALLWRLD EX US	922042775	1,430	28,352	SH		DFND	10	0	28,352	0
VANGUARD INTL EQUITY INDEX F	FTSE EUROPE ETF	922042874	23,013	438,931	SH		DFND	10	0	438,931	0
VANGUARD INTL EQUITY INDEX F	FTSE EMR MKT ETF	922042858	834	19,295	SH		DFND	10	0	19,295	0
VANGUARD SCOTTSDALE FDS	MORTG-BACK SEC	92206C771	279	5,132	SH		DFND	10	0	5,132	0
VANGUARD SCOTTSDALE FDS	INT-TERM CORP	92206C870	3,226	33,677	SH		DFND	10	0	33,677	0
VAREX IMAGING CORP	COM	92214X106	19,232	1,511,976	SH		DFND	2	0	1,511,976	0
VARIAN MED SYS INC	COM	92220P105	234,727	1,364,695	SH		DFND	4 9 10	0	1,248,203	116,492
VAXCYTE INC	COM	92243G108	199,839	4,196,429	SH		DFND	10	0	4,097,272	99,157
VEEVA SYS INC	CL A COM	922475108	218,305	776,362	SH		DFND	4 9	0	307,091	469,271
VENTAS INC	COM	92276F100	5,602	133,520	SH		DFND	4 9 10	0	133,520	0
VEREIT INC	COM	92339V100	2,947	453,167	SH		DFND	4 9	0	453,167	0
VERISIGN INC	COM	92343E102	99,647	486,128	SH		DFND	4 9	0	480,774	5,354
VERISK ANALYTICS INC	COM	92345Y106	369,881	1,996,035	SH		DFND	4 9 10	0	1,938,776	57,259
VERITEX HLDGS INC	COM	923451108	10,556	619,854	SH		DFND	2 10	0	619,854	0
VERIZON COMMUNICATIONS INC	COM	92343V104	217,832	3,663,078	SH		DFND	4 9 10	0	3,072,488	590,590
VERTEX INC	CL A	92538J106	15,355	667,613	SH		DFND	10	0	466,220	201,393
VERTEX PHARMACEUTICALS INC	COM	92532F100	517,279	1,900,957	SH		DFND	4 9 10	0	1,596,224	304,733
VIA OPTRONICS AG	SPONSORED ADS	91823Y109	2,687	300,000	SH		DFND	4	0	300,000	0
VIACOMCBS INC	CL B	92556H206	3,577	127,713	SH		DFND	4 9	0	127,713	0
VIAVI SOLUTIONS INC	COM	925550105	36,051	3,074,690	SH		DFND	4	0	3,074,690	0
VICI PPTYS INC	COM	925652109	525,001	22,469,560	SH		DFND	4 9 10 12	0	22,287,162	182,398
VIPSHOP HOLDINGS LIMITED	SPONSORED ADS A	92763W103	736	47,034	SH		DFND	9	0	47,034	0
VISA INC	COM CL A	92826C839	1,705,076	8,530,706	SH		DFND	4 9 10	0	7,629,331	901,375
VISHAY INTERTECHNOLOGY INC	COM	928298108	34,366	2,207,206	SH		DFND	2	0	2,207,206	0
VISTEON CORP	COM NEW	92839U206	185,724	2,683,100	SH		DFND	10	0	2,612,015	71,085
VISTRA CORP	COM	92840M102	39,652	2,102,488	SH		DFND	4 9 10	0	1,952,281	150,207
VIVINT SMART HOME INC	COM CL A	928542109	552	32,307	SH		DFND	10	0	32,307	0
VMWARE INC	CL A COM	928563402	51,108	355,734	SH		DFND	4 9	0	242,403	113,331
VODAFONE GROUP PLC NEW	SPONSORED ADR	92857W308	148	11,000	SH		DFND	4	0	11,000	0
VONAGE HLDGS CORP	COM	92886T201	159,795	15,620,231	SH		DFND	10	0	15,042,309	577,922
VORNADO RLTY TR	SH BEN INT	929042109	1,893	56,166	SH		DFND	4 9 10	0	56,166	0
VOYA FINANCIAL INC	COM	929089100	8,284	172,841	SH		DFND	4 9	0	105,701	67,140
VROOM INC	COM	92918V109	29,190	563,736	SH		DFND	10	0	552,378	11,358
VULCAN MATLS CO	COM	929160109	15,300	112,890	SH		DFND	2 4 9 11	0	112,684	206
WABTEC	COM	929740108	323,192	5,223,055	SH		DFND	4 9 10	0	5,081,074	141,981
WALGREENS BOOTS ALLIANCE INC	COM	931427108	46,543	1,295,750	SH		DFND	2 4 9	0	285,634	1,010,116
WALKER & DUNLOP INC	COM	93148P102	36,257	684,035	SH		DFND	4 10	0	665,967	18,068
WALMART INC	COM	931142103	364,663	2,606,446	SH		DFND	4 9 10	0	1,542,365	1,064,081
WARNER MUSIC GROUP CORP	COM CL A	934550203	50,309	1,750,474	SH		DFND	10	0	1,750,474	0
WARRIOR MET COAL INC	COM	93627C101	898	52,598	SH		DFND	10	0	52,598	0
WASHINGTON FED INC	COM	938824109	87,167	4,178,657	SH		DFND	2	0	4,178,657	0
WASTE CONNECTIONS INC	COM	94106B101	45,487	438,218	SH		DFND	2 4 9	0	438,218	0
WASTE CONNECTIONS INC	COM	94106B101	2,748	26,521	SH		DFND	4	0	26,521	0
WASTE MGMT INC DEL	COM	94106L109	94,329	833,513	SH		DFND	4 9 10	0	712,986	120,527
WATERS CORP	COM	941848103	333,357	1,703,584	SH		DFND	4 9 10	0	1,450,203	253,381
WATSCO INC	COM	942622200	2,640	11,334	SH		DFND	9	0	8,911	2,423
WATTS WATER TECHNOLOGIES INC	CL A	942749102	33,823	337,725	SH		DFND	2 4	0	337,725	0
WAYFAIR INC	CL A	94419L101	510,999	1,755,949	SH		DFND	4 9 10	0	1,704,992	50,957
WEC ENERGY GROUP INC	COM	92939U106	50,682	523,054	SH		DFND	4 9 10	0	315,810	207,244
WELLS FARGO CO NEW	COM	949746101	47,470	2,019,579	SH		DFND	2 4 9 10	0	1,724,591	294,988
WELLTOWER INC	COM	95040Q104	10,928	198,378	SH		DFND	4 9 10	0	198,378	0
WENDYS CO	COM	95058W100	98,710	4,427,451	SH		DFND	4 10	0	4,265,030	162,421
WEST PHARMACEUTICAL SVSC INC	COM	955306105	184,715	671,942	SH		DFND	4 9 10	0	384,947	286,995
WESTERN DIGITAL CORP.	COM	958102105	7,296	199,601	SH		DFND	4 9	0	192,148	7,453
WESTERN UN CO	COM	959802109	86,829	4,051,858	SH		DFND	4 9	0	2,220,424	1,831,434
WESTLAKE CHEM CORP	COM	960413102	29,543	467,306	SH		DFND	2 9	0	467,306	0
WESTLAKE CHEM PARTNERS LP	COM UNIT RP LP	960417103	28,385	1,513,852	SH		DFND	2	0	1,513,852	0
WESTROCK CO	COM	96145D105	4,342	124,996	SH		DFND	4 9 10	0	124,996	0
WEX INC	COM	96208T104	462,190	3,325,826	SH		DFND	4 10	0	3,179,526	146,300
WEYERHAEUSER CO MTN BE	COM NEW	962166104	85,670	3,003,890	SH		DFND	2 4 9 11	0	1,013,334	1,990,556
WHEATON PRECIOUS METALS CORP	COM	962879102	9,846	201,281	SH		DFND	4 9	0	201,281	0
WHIRLPOOL CORP	COM	963320106	16,270	88,476	SH		DFND	4 9	0	69,908	18,568
WILEY JOHN & SONS INC	CL A	968223206	1,331	41,967	SH		DFND	9	0	17,026	24,941
WILLIAMS COS INC	COM	969457100	24,905	1,267,713	SH		DFND	4 9	0	1,252,969	14,744
WILLIAMS SONOMA INC	COM	969904101	90,425	999,836	SH		DFND	9 10	0	942,810	57,026
WILLIS TOWERS WATSON PLC LTD	SHS	G96629103	374,292	1,792,302	SH		DFND	4 9 10	0	1,315,954	476,348
WINGSTOP INC	COM	974155103	302	2,213	SH		DFND	10	0	2,213	0
WINNEBAGO INDS INC	COM	974637100	372	7,202	SH		DFND	4 10	0	7,202	0
WIX COM LTD	SHS	M98068105	83,582	327,959	SH		DFND	4 9 10	0	151,176	176,783
WNS HLDGS LTD	SPON ADR	92932M101	115,404	1,804,317	SH		DFND	2 10	0	1,769,410	34,907
WORKDAY INC	CL A	98138H101	377,519	1,754,855	SH		DFND	4 9 10	0	1,485,838	269,017
WORLD WRESTLING ENTMT INC	CL A	98156Q108	284	7,022	SH		DFND	10	0	7,022	0
WP CAREY INC	COM	92936U109	3,636	55,796	SH		DFND	4 9	0	55,796	0
WSFS FINL CORP	COM	929328102	45,385	1,682,812	SH		DFND	2	0	1,682,812	0
WYNDHAM HOTELS & RESORTS INC	COM	98311A105	352	6,968	SH		DFND	10	0	6,968	0
WYNN RESORTS LTD	COM	983134107	2,401	33,438	SH		DFND	4 9	0	33,438	0
WYNN RESORTS LTD	COM	983134107	83	26,300	SH	Call	DFND	10	0	263	0
XCEL ENERGY INC	COM	98389B100	106,871	1,548,653	SH		DFND	4 9 10	0	899,520	649,133
XEROX HOLDINGS CORP	COM NEW	98421M106	10,347	551,227	SH		DFND	9	0	445,215	106,012
XILINX INC	COM	983919101	571,104	5,478,723	SH		DFND	4 9 10	0	4,207,179	1,271,544
XPO LOGISTICS INC	COM	983793100	2,174	25,677	SH		DFND	4 9	0	25,533	144
XYLEM INC	COM	98419M100	37,554	446,358	SH		DFND	4 9 10	0	446,358	0
YAMANA GOLD INC	COM	98462Y100	503	88,891	SH		DFND	4 9	0	88,891	0
YANDEX N V	SHS CLASS A	N97284108	5,994	91,886	SH		DFND	4 9	0	91,886	0
YEXT INC	COM	98585N106	79,114	5,211,722	SH		DFND	10	0	4,965,526	246,196
YUM BRANDS INC	COM	988498101	7,294	79,892	SH		DFND	4 9	0	79,892	0
YUM CHINA HLDGS INC	COM	98850P109	13,635	265,500	SH		DFND	10	0	265,500	0
YUM CHINA HLDGS INC	COM	98850P109	66,598	1,257,827	SH		DFND	4 9 10 12	0	919,026	338,801
ZAI LAB LTD	ADR	98887Q104	2,208	26,544	SH		DFND	9	0	26,544	0
ZEBRA TECHNOLOGIES CORPORATI	CL A	989207105	95,781	379,467	SH		DFND	4 9	0	211,240	168,227
ZENDESK INC	COM	98936J101	746,971	7,257,818	SH		DFND	4 10	0	6,488,150	769,668
ZILLOW GROUP INC	CL C CAP STK	98954M200	68,731	676,550	SH		DFND	4 9	0	129,779	546,771
ZILLOW GROUP INC	CL A	98954M101	8,241	81,159	SH		DFND	4 9	0	50,511	30,648
ZIMMER BIOMET HOLDINGS INC	COM	98956P102	18,675	137,184	SH		DFND	4 9	0	123,269	13,915
ZIONS BANCORPORATION N A	COM	989701107	1,127	38,564	SH		DFND	4 9	0	38,564	0
ZOETIS INC	CL A	98978V103	445,812	2,695,863	SH		DFND	4 9 10	0	2,484,662	211,201
ZOGENIX INC	COM NEW	98978L204	31,162	1,737,980	SH		DFND	10	0	1,642,124	95,856
ZOOM VIDEO COMMUNICATIONS IN	CL A	98980L101	51,841	110,286	SH		DFND	4 9	0	44,334	65,952
ZSCALER INC	COM	98980G102	11,455	81,421	SH		DFND	4 9	0	62,646	18,775
ZTO EXPRESS CAYMAN INC	SPONSORED ADS A	98980A105	22,797	762,130	SH		DFND	4 9 12	0	522,398	239,732
ZYNGA INC	CL A	98986T108	18,442	2,022,122	SH		DFND	9	0	1,358,757	663,365