QuickLinks -- Click here to rapidly navigate through this document
CERTIFICATION
In connection with the Quarterly Report on Form 10-Q of Helicos BioSciences Corporation (the "Company") for the period ended March 31, 2008 as filed with the Securities and Exchange Commission on the date hereof (the "Report), we Stanley N. Lapidus, the Principal Executive Officer of the Company, Stephen J. Lombardi, the Interim Principal Financial Officer of the Company, and Kevin G. Lafond, the Interim Principal Accounting Officer of the Company, hereby certify, pursuant to 18 U.S.C. 1350, as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002, to our knowledge that:
- (1)
- the Report fully complies with the requirements of Section 13(a) or 15(d), as applicable, of the Securities Exchange Act of 1934, as amended, and
- (2)
- the information in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company
Dated: May 13, 2008 | /s/ STANLEY N. LAPIDUS Stanley N. Lapidus Chairman and Chief Executive Officer (Principal Executive Officer) |
Dated: May 13, 2008 | /s/ STEPHEN J. LOMBARDI Stephen J. Lombardi President and Chief Operating Officer (Interim Principal Financial Officer) |
Dated: May 13, 2008 | /s/ KEVIN G. LAFOND Kevin G. Lafond Controller (Interim Principal Accounting Officer) |