Reynolds American (RAI) 10-K 2006 FY Annual report

EXHIBIT 32.1

REYNOLDS AMERICAN INC.

Certification Pursuant to 18 U.S.C. §1350

Pursuant to 18 U.S.C. §1350, as adopted pursuant to Section 906 of the Sarbanes — Oxley Act of 2002, the undersigned, Susan M. Ivey, Chief Executive Officer, and Dianne M. Neal, Chief Financial Officer, of Reynolds American Inc. (“RAI”), hereby certifies, to her knowledge, that:

1) RAI’s Annual Report onForm 10-K for the year ended December 31, 2006, fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

2) the information contained in RAI’s Annual Report onForm 10-K for the year ended December 31, 2006, fairly presents, in all material respects, the financial condition and results of operations of RAI.

EXECUTEDthis 27th day of February, 2007.

/s/  Susan M. Ivey

Susan M. Ivey

Chairman of the Board,
President and Chief Executive Officer
of Reynolds American Inc.

/s/  Dianne M. Neal

Dianne M. Neal

Executive Vice President and Chief Financial Officer
of Reynolds American Inc.