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Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in the Registration Statements onForm S-8 (File Numbers333-120229 and333-136101) of MarketAxess Holdings Inc. of our report dated February 27, 2008, relating to the consolidated financial statements, and the effectiveness of internal control financial reporting, which appears in thisForm 10-K.
/s/ PricewaterhouseCoopers LLP
PricewaterhouseCoopers LLP
New York, New York
March 3, 2008
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