Exhibit 23.1
CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM
We hereby consent to the incorporation by reference in this Registration Statement on Form S-8 of MarketAxess Holdings Inc. of our report dated February 23, 2022 relating to the financial statements and the effectiveness of internal control over financial reporting, which appears in MarketAxess Holdings Inc.’s Annual Report on Form 10-K for the year ended December 31, 2021.
| /s/ PricewaterhouseCoopers LLP |
| New York, NY |
| June 8, 2022 |
