Great Point Partners 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
ACCELERON PHARMA INC CMN	COM	00434H108	7,347	173,124	SH		DFND	1,2	173,124	0	0
ACORDA THERAPEUTICS INC CMN	COM	00484M106	4,290	200,000	SH	Put	DFND	1,2	200,000	0	0
AIMMUNE THERAPEUTICS, INC. CMN	COM	00900T107	21,692	573,550	SH		DFND	1,2	573,550	0	0
AMARIN CORPORATION PLC SPONSORED ADR CMN	SPONS ADR NEW	023111206	4,238	1,056,825	SH		DFND	1,2	1,056,825	0	0
ARENA PHARMACEUTICALS, INC. CMN	COM NEW	040047607	39,987	1,177,119	SH		DFND	1,2	1,177,119	0	0
BIOCRYST PHARMACEUTICALS INC CMN	COM	09058V103	23,332	4,751,883	SH		DFND	1,2	4,751,883	0	0
CATALYST PHARMACEUTICAL INC.CMN	COM	14888U101	14,926	3,817,288	SH		DFND	1,2	3,817,288	0	0
CONCERT PHARMACEUTICALS INC CMN	COM	206022105	17,319	669,472	SH		DFND	1,2	669,472	0	0
CORBUS PHARMACEUTICALS HOLDINGS, INC. CMN	COM	21833P103	4,260	600,000	SH		DFND	1,2	600,000	0	0
DBV TECHNOLOGIES SA SPONSORED ADR CMN	SPONSORED ADR	23306J101	7,703	313,140	SH		DFND	1,2	313,140	0	0
DERMIRA INC CMN	COM	24983L104	1,214	43,637	SH		DFND	1,2	43,637	0	0
GW PHARMACEUTICALS PLC ADR CMN	ADS	36197T103	9,901	75,000	SH		DFND	1,2	75,000	0	0
GLOBAL BLOOD THERAPEUTICS, INC. CMN	COM	37890U108	31,606	803,205	SH		DFND	1,2	803,205	0	0
GLOBAL BLOOD THERAPEUTICS, INC. CMN	COM	37890U108	7,870	200,000	SH	Call	DFND	1,2	200,000	0	0
INCYTE CORPORATION CMN	COM	45337C102	6,660	70,323	SH		DFND	1,2	70,323	0	0
IOVANCE BIOTHERAPEUTICS, INC. CMN	COM	462260100	16,000	2,000,000	SH		DFND	1,2	2,000,000	0	0
JOUNCE THERAPEUTICS INC CMN	COM	481116101	3,732	292,673	SH		DFND	1,2	292,673	0	0
KADMON HOLDINGS INC CMN	COM	48283N106	3,042	840,303	SH		DFND	1,2	840,303	0	0
KURA ONCOLOGY, INC. CMN	COM	50127T109	33,618	2,197,283	SH		DFND	1,2	2,197,283	0	0
NEUROCRINE BIOSCIENCES INC CMN	COM	64125C109	31,036	400,000	SH		DFND	1,2	400,000	0	0
NEWLINK GENETICS CORPORATION CMN	COM	651511107	16,115	1,987,099	SH		DFND	1,2	1,987,099	0	0
PTC THERAPEUTICS, INC. CMN	COM	69366J200	18,111	1,085,800	SH		DFND	1,2	1,085,800	0	0
REVANCE THERAPEUTICS INC CMN	COM	761330109	10,725	300,000	SH		DFND	1,2	300,000	0	0
RIGEL PHARMACEUTICALS INC CMN	COM NEW	766559603	30,608	7,888,581	SH		DFND	1,2	7,888,581	0	0
SAGE THERAPEUTICS, INC CMN	COM	78667J108	32,942	200,000	SH		DFND	1,2	200,000	0	0
SAVARA INC CMN	COM	805111101	12,903	869,500	SH		DFND	1,2	869,500	0	0
SPARK THERAPEUTICS INC CMN	COM	84652J103	21,128	410,900	SH		DFND	1,2	410,900	0	0
STREAMLINE HEALTH SOLUTNS, INC CMN	COM	86323X106	220	130,137	SH		DFND	1,2	130,137	0	0
VANDA PHARMACEUTICALS INC. CMN	COM	921659108	12,122	797,531	SH		DFND	1,2	797,531	0	0
ZOGENIX INC CMN	COM NEW	98978L204	44,909	1,121,331	SH		DFND	1,2	1,121,331	0	0
AXOVANT SCIENCES LTD CMN	COM	G0750W104	15,020	2,850,000	SH		DFND	1,2	2,850,000	0	0
BIOHAVEN PHARMACEUTICAL HOLDING CO LTD. CMN	COM	G11196105	13,495	500,192	SH		DFND	1,2	500,192	0	0
MYOVANT SCIENCES LTD CMN	COM	G637AM102	2,029	160,530	SH		DFND	1,2	160,530	0	0
NOVOCURE, LTD. CMN	ORD SHS	G6674U108	17,762	879,286	SH		DFND	1,2	879,286	0	0
FOAMIX PHARMACEUTICALS LIMITED CMN	SHS	M46135105	28,738	4,781,708	SH		DFND	1,2	4,781,708	0	0
WAVE LIFE SCIENCES PTE LTD CMN	SHS	Y95308105	11,621	331,085	SH		DFND	1,2	331,085	0	0
CIDARA THERAPEUTICS, INC.	COM	171757107	5,440	800,000	SH		DFND	1,2	800,000	0	0
SELECTA BIOSCIENCES, INC.	COM	816212104	1,745	177,900	SH		DFND	1,2	177,900	0	0
CONNECTURE INC	COM	20786J106	660	4,127,232	SH		DFND	1,2	4,127,232	0	0