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Exhibit 4.3
AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
THIS AMENDMENT NO. 1 TO AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (the "Amendment") is made and entered into as of this day of April, 2004, by and amongFAVRILLE, INC., a Delaware corporation (the "Company"), and the investors listed onSchedule A attached hereto (each of which is referred to herein as an "Investor" and all of which are collectively referred to herein as the "Investors").
WHEREAS, concurrently herewith, the Company and certain of the Investors have entered into that certain Amendment No. 1 to Series C Preferred Stock Purchase Agreement (the "Purchase Amendment") pursuant to which the Company is selling and issuing, and the New Investors (as defined in the Purchase Amendment) are purchasing, an aggregate of shares of the Company's Series C Preferred Stock, par value $0.001 per share (the "Additional Shares");
WHEREAS, the Company and the Investors (other than the New Investors) are parties to that certain Amended and Restated Investor Rights Agreement dated March 26, 2004 (the "Investor Rights Agreement"). Any capitalized term used in this Amendment and not defined herein shall have the meaning assigned to such term in the Investor Rights Agreement;
WHEREAS, Section 3.7 of the Investor Rights Agreement provides that the Investor Rights Agreement may be amended only with the written consent of (i) the Company, (ii) the holders of a majority of the Registrable Securities then outstanding, (iii) the holders of 662/3% of the Series A Stock then outstanding, (iv) the holders of 662/3% of the Series B Stock and the Series B-2 Stock then outstanding, voting together as a single class, and (v) the holders of 51% of the Series C Stock then outstanding; and
WHEREAS, in connection with the consummation of the transactions contemplated by the Purchase Amendment, the parties to the Investor Rights Agreement wish to amend the Investor Rights Agreement to cause each of the New Investors to become a party to the Investor Rights Agreement.
NOW THEREFORE, in consideration of the foregoing promises and the mutual covenants set forth herein, the Company and the Investors agree as follows:
1. AMENDMENT OF INVESTOR RIGHTS AGREEMENT.
(a) Effective as of the Second Closing Date (as defined in the Purchase Amendment), each of the New Investors shall become a party to the Investor Rights Agreement and shall be deemed both an "Investor" and a "Holder" for purposes of the Investor Rights Agreement, and the shares of Series C Stock purchased by such New Investors shall be deemed "Registrable Securities" for purposes of the Investor Rights Agreement.
(b) The Company and the Investors hereby agree that the provisions of Section 2.5 of the Investor Rights Agreement shall not apply to the offer or sale of the Additional Shares to the New Investors.
2. COUNTERPARTS. This Amendment may be executed in any number of counterparts, each of which shall be an original, but all of which together shall constitute one instrument.
3. NO OTHER CHANGES. Except as otherwise provided herein, all the terms and conditions of the Agreement which are not inconsistent herewith shall remain in full force and effect and shall apply equally to this Amendment.
[THE REMAINDER OF THIS PAGE INTENTIONALLY LEFT BLANK]
1
IN WITNESS WHEREOF, the parties hereto have executed thisAMENDMENT NO. 1 TO AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENTas of the date set forth in the first paragraph hereof.
FAVRILLE, INC. | |||
By: | |||
/s/ JOHN P. LONGENECKER John P. Longenecker President and Chief Executive Officer | |||
Address: | 10421 Pacific Center Court Suite 150 San Diego, CA 92121 | ||
Fax: | (858) 526-8000 | ||
INVESTORS: | |||
WILLIAM BLAIR CAPITAL PARTNERS VII, L.P. | |||
By: | William Blair Capital Management VII, L.P. Its: General Partner | ||
By: | William Blair Capital Management VII, L.L.C. | ||
Its: | General Partner | ||
By: | |||
/s/ A.M. MINOCHERHOMJEE | |||
Name: | Arda Minocherhomjee | ||
Its: | Managing Director | ||
Address: | 227 West Monroe Street Suite 3500 Chicago, Illinois 60606 | ||
Fax: | (312) 236-5782 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
WILLIAM BLAIR CAPITAL PARTNERS VII QP, L.P. | |||
By: | William Blair Capital Management VII, L.P. | ||
Its: | General Partner | ||
By: | William Blair Capital Management VII, L.L.C. | ||
Its: | General Partner | ||
By: | |||
/s/ A.M. MINOCHERHOMJEE | |||
Name: | Arda Minocherhomjee | ||
Its: | Managing Director | ||
Address: | 227 West Monroe Street Suite 3500 Chicago, Illinois 60606 | ||
Fax: | (312) 236-5782 | ||
ALLOY PARTNERS 2000, L.P. ALLOY VENTURES 2000, L.P. ALLOY CORPORATE 2000, L.P. ALLOY INVESTORS 2000, L.P. | |||
By: | Alloy Ventures 2000, LLC | ||
Their: | General Partner | ||
/s/ DOUGLAS E. KELLY Managing Member of Alloy Ventures 2000, LLC | |||
Address: | 480 Cowpers Street 2nd Floor Palo Alto, CA 94301 | ||
Fax: | (650) 687-5010 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
ALLOY ANNEX I, L.P. | |||
By: | Alloy Annex I, LLC | ||
Its: | General Partner | ||
/s/ DOUGLAS E. KELLY Managing Member of Alloy Annex I, LLC | |||
Address: | 480 Cowpers Street, 2nd Floor Palo Alto, CA 94301 | ||
DE NOVO VENTURES I, LP DE NOVO (Q) VENTURES I, LP | |||
By: | De Novo Management LLC | ||
Their: | General Partner | ||
/s/ FRED DOTZLER Fred Dotzler, Managing Director | |||
Address: | 1550 El Camino Real Suite 150 Menlo Park, CA 94025 | ||
Fax: | (650) 329-1315 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
SANDERLING VENTURE PARTNERS V, L.P. SANDERLING V BIOMEDICAL, L.P. SANDERLING V LIMITED PARTNERSHIP SANDERLING V BETEILIGUNGS GMBH & CO. KG SANDERLING VENTURE PARTNERS V CO-INVESTMENT FUND, L.P. SANDERLING V BIOMEDICAL CO-INVESTMENT FUND, L.P. | |||
By: | Middleton, McNeil & Mills Associates V, LLC | ||
/s/ FRED MIDDLETON Fred A. Middleton Managing Director | |||
Address: | 400 South El Camino Real Suite 1200 San Mateo, CA 94402 | ||
Fax: | (650) 375-7077 | ||
SANDERLING V VENTURES MANAGEMENT | |||
/s/ FRED MIDDLETON Fred A. Middleton Owner | |||
Address: | 400 South El Camino Real Suite 1200 San Mateo, CA 94402 | ||
Fax: | (650) 375-7077 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
FORWARD VENTURES III INSTITUTIONAL PARTNERS L.P. | |||
By: | Forward III Associates, LLC | ||
By: | |||
/s/ IVOR ROYSTON | |||
Name: | |||
Ivor Royston, M.D. | |||
Title: | |||
Managing Member | |||
Address: | 9393 Towne Centre Drive Suite 200 San Diego, CA 92121 | ||
Fax: | (858) 452-8799 | ||
FORWARD VENTURES III L.P. | |||
By: | Forward III Associates, LLC | ||
By: | |||
/s/ IVOR ROYSTON | |||
Name: | |||
Ivor Royston, M.D. | |||
Title: | |||
Managing Member | |||
Address: | 9393 Towne Centre Drive Suite 200 San Diego, CA 92121 | ||
Fax: | (858) 452-8799 | ||
FORWARD VENTURES IV B L.P. | |||
By: | Forward IV Associates, LLC | ||
By: | |||
/s/ IVOR ROYSTON | |||
Name: | |||
Ivor Royston, M.D. | |||
Title: | |||
Managing Member | |||
Address: | 9393 Towne Centre Drive Suite 200 San Diego, CA 92121 | ||
Fax: | (858) 452-8799 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
FORWARD VENTURES IV L.P. | |||
By: | Forward IV Associates, LLC | ||
By: | |||
/s/ IVOR ROYSTON | |||
Name: | |||
Ivor Royston, M.D. | |||
Title: | |||
Managing Member | |||
Address: | 9393 Towne Centre Drive Suite 200 San Diego, CA 92121 | ||
Fax: | (858) 452-8799 | ||
JACOBS INVESTMENT COMPANY, LLC | |||
By: | |||
/s/ GARY E. JACOBS | |||
Name: | |||
Gary E. Jacobs | |||
Title: | |||
Manager | |||
Address: | 13974 Boquito Drive Del Mar, CA 92014 | ||
STEPHEN J. KANDEL SSB ROTH CONVERSION IRA CUST. | |||
By: | |||
Name: | Stephen J. Kandel | ||
Title: | Beneficial Owner | ||
Address: | 1021 Muirlands Drive La Jolla, CA 92037 | ||
SANDEN KANDEL | |||
Address: | 1021 Muirlands Drive La Jolla, CA 92037 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
EBR HOLDINGS II LTD. | |||
By: | |||
Name: | |||
Title: | |||
Address: | 3366 N. Torrey Pines Ct. Suite 210 La Jolla, CA 92037 | ||
ELLIOT FEUERSTEIN | |||
Address: | 8588 Ruette Monte Carlo La Jolla, CA 92037 | ||
MICHAEL M. BERNS LIVING TRUST DATED 10/16/90, MICHAEL M. BERNS, TRUSTEE | |||
By: | |||
Michael M. Berns Trustee | |||
Address: | 1617 Emerald Bay Laguna Beach, CA 92651 | ||
THE PAYNE FAMILY TRUST DATED 1/23/85, ERROL G. PAYNE AND NAOMI F. PAYNE, TRUSTEES | |||
By: | |||
Errol G. Payne and Naomi F. Payne Trustees | |||
Address: | 21 Ritz Cove Drive Dana Point, CA 92629 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
JOSHUA COHEN AND LITA COHEN | |||
Address: | 8010 Frost Street, Suite 408 San Diego, CA 92123 | ||
MICHAEL S. GROSSMAN UBS IRA ROLLOVER DG87091-68 | |||
By: | |||
/s/ MICHAEL S. GROSSMAN | |||
Name: | Michael S. Grossman | ||
Title: | Owner | ||
Address: | 310 Forward Street La Jolla, CA 92037 | ||
MARGARET GROSSMAN UBS IRA DG44753 | |||
By: | |||
/s/ MARGARET STEVENS GROSSMAN | |||
Name: | Margaret Grossman | ||
Title: | Owner | ||
Address: | 310 Forward Street La Jolla, CA 92037 | ||
GUILIO WASSMER | |||
Address: | Schlyffistrasse 15 8806 Bäch Switzerland | ||
/s/ CHRISTOPH DIETSCHE CHRISTOPH DIETSCHE | |||
Address: | Jurastrasse 27 CH-5000 Aarau Switzerland |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
WARNKE BROADLEY KENNEDY FAMILY TRUST DATED 3/29/89, JOSEPH F. KENNEDY, TRUSTEE, GERIANN WARNKE, TRUSTEE | |||
By: | |||
/s/ JOSEPH F. KENNEDY | |||
Name: | Joseph F. Kennedy | ||
Title | Trustee | ||
Address: | 6390 Cardeno Drive La Jolla, CA 92037 | ||
IRA M. LECHNER & WINIFRED EILEEN HAAG FAMILY TRUST DATED 1/21/00: IRA M. LECHNER & WINIFRED EILEEN HAAG TRUSTEES | |||
By: | |||
/s/ IRA M. LECHNER | |||
Name: | |||
Ira M. Lechner | |||
Title: | |||
Trustee | |||
Address: | 19811 4th Place Escondido, CA 92029 | ||
MORGAN STANLEY DW INC. CUSTODIAN FOR IRA M. LECHNER (MSDW TAX ID #94-1671384) | |||
By: | |||
/s/ IRA M. LECHNER | |||
Name: | Ira M. Lechner | ||
Title: | Trustee | ||
Address: | 19811 4th Place Escondido, CA 92029 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
NEVINS MCBRIDE | |||
Address: | |||
ALFRED AND ADELE SALEH FAMILY TRUST | |||
By: | |||
Name: | Fred Saleh | ||
Title: | |||
Address: | 14845 Caminito Lorren Del Mar, CA 92014 | ||
LAWRENCE BIER | |||
Address: | 13 Blueberry Ridge Court Rockville, MD 20854 | ||
DENNIS FAMILY TRUST DATED 3/29/93, EDWARD A. DENNIS, TRUSTEE, MARTHA G. DENNIS, TRUSTEE | |||
By: | |||
/s/ EDWARD A. DENNIS, /s/ MARTHA G. DENNIS Edward A. Dennis and Martha G. Dennis Trustees | |||
Address: | 1921 Hypatia Way La Jolla, CA 92037 | ||
/s/ ELLIOTT ROYSTON ELLIOTT ROYSTON | |||
Address: | 1634 Ponce de Leon Ave., #207 Atlanta, GA 30307 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
DAVID W. ODMARK | |||
Address: | |||
INDOFIN, NV | |||
By: | |||
Name: | Pieter van Dongen | ||
Title: | Director | ||
Address: | c/o Avobone S.A. 9, Place du Bourg-de-Four 1204 Geneva Switzerland 1204 | ||
HOWARD ALTMANN | |||
Address: | P.O. Box 1965 New York, NY 10013 | ||
LOTUS BIOSCIENCE INVESTMENT HOLDINGS LIMITED | |||
By: | |||
Name: | Wong Ken Lum and Mong Cheuk Wai | ||
Title: | Directors | ||
Address: | 9th Floor, Central Building Pedder Street, Hong Kong |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
MERCER REVOCABLE FAMILY TRUST DTD 7/13/89 | |||
By: | |||
Name: | Thomas Mercer | ||
Title: | Trustee | ||
Address: | P.O. Box 842 Rancho Santa Fe, CA 92067 | ||
WEIL FAMILY TRUST OF 1980, CHRISTOPHER WEIL AND PATRICIA WEIL | |||
By: | |||
/s/ CHRISTOPHER WEIL | |||
Name: | Christopher Weil | ||
Title: | Trustee | ||
Address: | 12555 High Bluff Dr. San Diego, CA 92130 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
GC&H INVESTMENTS | |||
By: | |||
/s/ JOHN L. CARDOZA | |||
Name: | John L. Cardoza | ||
Title: | Executive Partner | ||
Address: | One Maritime Plaza 20th Floor San Francisco, CA 94111 | ||
GC&H INVESTMENTS, LLC | |||
By: | |||
/s/ JOHN L. CARDOZA | |||
Name: | John L. Cardoza | ||
Title: | Executive Partner | ||
Address: | One Maritime Plaza 20th Floor San Francisco, CA 94111 | ||
GRAY GHOST, LLC | |||
By: | |||
/s/ PHILIP GOELET | |||
Name: | |||
Philip Goelet | |||
Title: | Manager | ||
Address: | c/o Red Abbey, LLC 2330 West Joppa Road Suite 330 Lutherville, MD 21093 | ||
Fax: | (410) 494-4247 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
HELLER FINANCIAL LEASING, INC. | |||
By: | |||
/s/ MARK KING | |||
Name: | Mark King | ||
Title: | Sr. Vice President | ||
Address: | 500 W. Monroe Street Chicago, IL 60661 Attn: GE Technology Finance—Portfolio Management | ||
Fax: | (312) 876-2593 | ||
PRIVATE EQUITY HOLDING-FAVRILLE, L.L.C. | |||
By: | Howard Hughes Medical Institute | ||
Its: | Sole Member and Manager | ||
By: | |||
/s/ MARK A. BARNARD | |||
Name: | |||
Mark A. Barnard | |||
Title: | |||
Managing Director | |||
Address: | 4000 Jones Bridge Road Chevy Chase, MD 20815 | ||
Fax: | (301) 215-8691 | ||
SFP BIOTECH PARTNERS | |||
By: | |||
/s/ STEVEN LEE YAMSHON Steven Lee Yamshon Managing Partner | |||
Address: | 1851 E. First Street #150 Santa Ana, CA 92705 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
STEPHEN J. KANDEL SSB ROTH CONVERSION IRA CUST. | |||
By: | |||
/s/ STEPHEN J. KANDEL | |||
Name: | Stephen J. Kandel | ||
Title: | Beneficial Owner | ||
Address: | 1021 Muirlands Drive La Jolla, CA 92037 | ||
/s/ STEPHEN J. KANDEL STEPHEN AND GENEVIEVE KANDEL | |||
Address: | P.O. Box 1891 Rancho Santa Fe, CA 92067 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
OAKWOOD MEDICAL MANAGEMENT IV (QP), L.L.C. | |||
By: | Oakwood Medical Management IV, L.L.C. | ||
Its: | Manager | ||
By: | |||
Name: | Raul E. Perez, M.D. | ||
Title: | President | ||
Address: | 439 Kirkwood Road, Suite 208 St. Louis, Missouri 63122 | ||
OAKWOOD MEDICAL INVESTORS IV, L.L.C. | |||
By: | Oakwood Medical Management IV, L.L.C. | ||
Its: | Manager | ||
By: | |||
Name: | Raul E. Perez, M.D. | ||
Title: | President | ||
Address: | 439 Kirkwood Road, Suite 208 St. Louis, Missouri 63122 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
COMMUNITY INVESTMENT PARTNERS V L.P., LLLP | |||
By: | CIP Management L.P., LLLP | ||
Its: | Managing General Partner | ||
By: | |||
Name: | Daniel A. Burkhardt | ||
Title: | Chairman of CIP Management, Inc., Managing General Partner of CIP Management L.P., LLLP | ||
Address: | 12555 Manchester Road St. Louis, Missouri 63131 | ||
PIPER JAFFRAY HEALTHCARE FUND IV, L.P. | |||
By: | Piper Jaffray Healthcare Management IV, LLC | ||
Its: | General Partner | ||
By: | |||
/s/ HEATH LUKATCH Heath Lukatch, Managing Director of Piper Jaffray Ventures Inc., its General Partner | |||
Address: | 100 Spear Street, Suite 1600 San Francisco, CA 94105 | ||
Fax: | (415) 979-9488 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
AVTECH PORTFOLIO, L.P. | |||
By: | AVTech Ventures II, LLC | ||
Its: | General Partner | ||
By: | |||
Gary L. Shields, Managing Member | |||
Address: | 1201 Camino Del Mar, Suite 215 Del Mar, CA 92014 | ||
Fax: | (858) 356-3563 | ||
MATTHEW C. & IRIS LYNN STRAUSS, CO-TRUSTEES OF STRAUSS FAMILY TRUST DTD. 6/5/92 | |||
By: | |||
/s/ MATTHEW STRAUSS | |||
Name: | Matthew C. Strauss | ||
Title | Co-Trustee | ||
Address: | c/o MC Strauss Company 990 Highland Drive, Suite 200 Solana Beach, CA 92075 | ||
Fax: | (858) 792-7834 | ||
BOSTON LIFE SCIENCE VENTURE CORP. | |||
By: | |||
/s/ KENNETH LO | |||
Name: | Kenneth C.M. Lo | ||
Title: | Chairman | ||
Address: | 5th Fl. No. 420 Fu-Hsin N. Road Taipei, Taiwan |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
THOMAS A. SHIFTAN AND MAUREEN E. SHIFTAN, CO-TRUSTEES OF SHIFTAN FAMILY TRUST DTD. 3/23/98 | |||
By: | |||
/s/ THOMAS SHIFTAN | |||
Name: | Thomas A. Shiftan | ||
Title | Co-Trustee | ||
Address: | 7040 Neptune Place La Jolla, CA 92037 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
NEEDHAM CAPITAL SBIC III, L.P. NEEDHAM CAPITAL PARTNERS IIIA, L.P. NEEDHAM CAPITAL PARTNERS III (BERMUDA), L.P. | |||
By: | |||
/s/ JOHN J. PRIOR, JR. | |||
Name: | |||
John J. Prior, Jr. | |||
Title: | |||
General Partner | |||
Address: | Needham Asset Management 445 Park Avenue New York, NY 10022 |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
1998 CO-INVESTING LLC EIN 43-1831139 | |||
By: | |||
/s/ JEFFREY MCDONNELL | |||
Name: | Jeff McDonnell | ||
Title | Title Manager | ||
Address: | 1034 S. Brentwood, Suite 1860 St. Louise, MO 63117 | ||
SCHRODERS & CO. BANK SA | |||
By: | |||
/s/ SAMUEL MOULIN | |||
Name: | |||
Samuel Moulin | |||
Title: | |||
Director | |||
Address: | 8, Rue D'Italie Geneve, Switzerland |
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
/s/ ERIC W. ROBERTS ERIC W. ROBERTS | |||
Address: | 205 E 78th St., #4H New York, NY 10022 | ||
SCHEIBLER-LEHENY FAMILY LIVING TRUST U/D/T JUNE 6, 2001 | |||
By: | |||
/s/ EDWARD M. SCHEIBLER | |||
By: | |||
/s/ A. RACHEL LEHENY | |||
Names: | Edward G. Scheibler, Trustee A. Rachel Leheny, Trustee | ||
Address: | |||
P.O. Box 647 | |||
Rancho Santa Fe, CA 92067 | |||
THE NICHOLAS & PADDI ARTHUR TRUST DATED 4-14-98 | |||
By: | |||
/s/ NICHOLAS ARTHUR | |||
By: | |||
/s/ PADDI ARTHUR | |||
Names: | Nicholas Arthur, Co-Trustee Paddi Arthur, Co-Trustee | ||
Address: | |||
[SIGNATURE PAGE TO AMENDMENT NO. 1 TO
AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT]
INVESTOR
William Blair Capital Partners VII, L.P.
William Blair Capital Partners VII QP, L.P.
Alloy Partners 2000, L.P.
Alloy Ventures 2000, L.P.
Alloy Corporate 2000, L.P.
Alloy Investors 2000, L.P.
Alloy Annex I, L.P.
De Novo Ventures I, LP
De Novo (Q) Ventures I, LP
Sanderling Venture Partners V, L.P.
Sanderling V Biomedical, L.P.
Sanderling V Limited Partnership
Sanderling V Beteiligungs GmbH & Co. KG
Sanderling V Ventures Management
Sanderling Venture Partners V Co-Investment Fund, L.P.
Sanderling V Biomedical Co-Investment Fund, L.P.
Forward Ventures III Institutional Partners L.P.
Forward Ventures III L.P.
Forward Ventures IV B L.P.
Forward Ventures IV L.P.
Jacobs Investment Company, LLC
Stephen J. Kandel SSB Roth Conversion IRA Cust.
Sanden Kandel
EBR Holdings II Ltd.
Elliot Feuerstein
Michael M. Berns Living Trust Dated 10/16/90, Michael M. Berns, Trustee
The Payne Family Trust Dated 1/23/85, Errol G. Payne and Naomi F. Payne, Trustees
Joshua Cohen and Lita Cohen
Michael S. Grossman UBS IRA Rollover DG87091-68
Margaret Grossman UBS IRA DG44753
Guilio Wassmer
Christoph Dietsche
Warnke Broadley Kennedy Family Trust Dated 3/29/89, Joseph F. Kennedy, Trustee, Geriann Warnke, Trustee
Ira M. Lechner & Winifred Eileen Haag Family Trust Dated 1/21/00: Ira M. Lechner & Winifred Eileen Haag Trustees
Morgan Stanley DW Inc. Custodian for Ira M. Lechner (MSDW Tax ID #94-1671384)
Nevins McBride
Alfred and Adele Saleh Family Trust
Lawrence Bier
Dennis Family Trust Dated 3/29/93, Edward A. Dennis, Trustee, Martha G. Dennis, Trustee
Elliott Royston
David W. Odmark
Indofin, NV
Howard Altmann
Lotus Bioscience Investment Holdings Limited
Mercer Revocable Family Trust DTD 7/13/89
Weil Family Trust of 1980, Christopher Weil and Patricia Weil
GC&H Investments
GC&H Investments, LLC
Gray Ghost, LLC
Heller Financial Leasing, Inc.
SFP Biotech Partners
Schroders & Co. Bank SA
Antonio J. Grillo-Lopez and Maria S. Grillo Trustees Grillo-Marxuach Family Trust dated 6-28-95
Private Equity Holding-Favrille, L.L.C.
Stephen Kandel CGM Roth Conversion IRA CUST A/C #119-51879-17-380
Stephan and Genevieve Kandel
Oakwood Medical Investors IV (QP), L.L.C.
Oakwood Medical Investors IV, L.L.C.
Community Investment Partners V L.P., LLLP
Piper Jaffray Healthcare Fund IV, L.P.
AVTech Portfolio, L.P.
Matthew C. & Iris Strauss, co-trustees of Strauss Family Trust dtd. 6/5/92
Boston Life Science Venture Corp.
Thomas A. Shiftan and Maureen E. Shiftan, co-trustees of Shiftan Family Trust dated 3/23/98
[ADD NEW SERIES C INVESTORS]
AMENDMENT NO. 1 TO AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
RECITALS
AGREEMENT
SCHEDULE A INVESTORS