Document_and_Entity_Informatio
Document and Entity Information | 6 Months Ended | |
Jun. 30, 2014 | Aug. 05, 2014 | |
Document Information [Line Items] | ' | ' |
Document Type | '10-Q | ' |
Amendment Flag | 'false | ' |
Document Period End Date | 30-Jun-14 | ' |
Document Fiscal Year Focus | '2014 | ' |
Document Fiscal Period Focus | 'Q2 | ' |
Trading Symbol | 'OMER | ' |
Entity Registrant Name | 'OMEROS CORP | ' |
Entity Central Index Key | '0001285819 | ' |
Current Fiscal Year End Date | '--12-31 | ' |
Entity Filer Category | 'Accelerated Filer | ' |
Entity Common Stock, Shares Outstanding | ' | 33,995,840 |
CONSOLIDATED_BALANCE_SHEETS
CONSOLIDATED BALANCE SHEETS (USD $) | Jun. 30, 2014 | Dec. 31, 2013 |
In Thousands, unless otherwise specified | ||
Current assets: | ' | ' |
Cash and cash equivalents | $1,533 | $1,384 |
Short-term investments | 35,927 | 12,717 |
Grant and other receivables | 252 | 379 |
Prepaid expenses | 1,110 | 251 |
Other current assets | 146 | 86 |
Total current assets | 38,968 | 14,817 |
Property and equipment, net | 907 | 939 |
Restricted cash | 679 | 679 |
Other assets | 439 | 100 |
Total assets | 40,993 | 16,535 |
Current liabilities: | ' | ' |
Accounts payable | 5,085 | 2,329 |
Accrued expenses | 5,476 | 3,944 |
Current portion of notes payable, net of discount | 1,609 | 5,600 |
Total current liabilities | 12,170 | 11,873 |
Notes payable, net of current portion and discount | 30,761 | 14,898 |
Deferred rent | 8,673 | 8,148 |
Commitments and contingencies (Note 8) | ' | ' |
Shareholders’ equity: | ' | ' |
Preferred stock, par value $0.01 per share: Authorized shares - 20,000,000 at March 31, 2014 (unaudited) and December 31, 2013; Issued and outstanding shares—none | ' | ' |
Common stock, par value $0.01 per share: Authorized shares - 150,000,000 at March 31, 2014 (unaudited) and December 31, 2013; Issued and outstanding shares—33,901,591 and 30,359,508 at March 31, 2014 (unaudited) and December 31, 2013, respectively | 340 | 304 |
Additional paid-in capital | 278,055 | 235,685 |
Accumulated deficit | -289,006 | -254,373 |
Total shareholders’ equity (deficit) | -10,611 | -18,384 |
Total liabilities and shareholders’ equity | $40,993 | $16,535 |
CONSOLIDATED_BALANCE_SHEETS_Pa
CONSOLIDATED BALANCE SHEETS (Parenthetical) (USD $) | Jun. 30, 2014 | Dec. 31, 2013 |
Preferred stock, par value (USD per share) | $0.01 | $0.01 |
Preferred stock, authorized shares | 20,000,000 | 20,000,000 |
Preferred stock, Issued shares | 0 | 0 |
Preferred stock, outstanding shares | 0 | 0 |
Common stock, par value (USD per share) | $0.01 | $0.01 |
Common stock, authorized shares | 150,000,000 | 150,000,000 |
Common stock, Issued shares | 33,994,432 | 30,359,508 |
Common stock, outstanding shares | 33,994,432 | 30,359,508 |
CONSOLIDATED_STATEMENTS_OF_OPE
CONSOLIDATED STATEMENTS OF OPERATIONS AND COMPREHENSIVE LOSS (USD $) | 3 Months Ended | 6 Months Ended | ||
In Thousands, except Share data, unless otherwise specified | Jun. 30, 2014 | Jun. 30, 2013 | Jun. 30, 2014 | Jun. 30, 2013 |
Revenue | $45 | $140 | $145 | $1,235 |
Operating expenses: | ' | ' | ' | ' |
Research and development | 12,407 | 9,564 | 24,424 | 16,691 |
Selling, general and administrative | 4,855 | 3,736 | 8,622 | 7,724 |
Total operating expenses | 17,262 | 13,300 | 33,046 | 24,415 |
Loss from operations | -17,217 | -13,160 | -32,901 | -23,180 |
Investment income | 5 | 2 | 7 | 8 |
Interest expense | -939 | -589 | -1,611 | -1,176 |
Other income (expense), net | 160 | 155 | -128 | 267 |
Net loss | -17,991 | -13,592 | -34,633 | -24,081 |
Comprehensive loss | ($17,991) | ($13,592) | ($34,633) | ($24,081) |
Basic and diluted net loss per share (USD per share) | ($0.53) | ($0.48) | ($1.07) | ($0.89) |
Weighted-average shares used to compute basic and diluted net loss per share (shares) | 33,933,356 | 28,199,739 | 32,415,198 | 27,053,946 |
CONSOLIDATED_STATEMENTS_OF_CAS
CONSOLIDATED STATEMENTS OF CASH FLOWS (USD $) | 6 Months Ended | |
In Thousands, unless otherwise specified | Jun. 30, 2014 | Jun. 30, 2013 |
Operating activities: | ' | ' |
Net loss | ($34,633) | ($24,081) |
Adjustments to reconcile net loss to net cash used in operating activities: | ' | ' |
Gain on disposal of assets | -9 | 0 |
Depreciation and amortization | 164 | 145 |
Stock-based compensation expense | 3,417 | 2,153 |
Non-cash interest expense | 331 | 242 |
Warrant modification expense | 452 | 41 |
Changes in operating assets and liabilities: | ' | ' |
Grant and other receivables | 127 | 1,219 |
Prepaid expenses and other current and noncurrent assets | -1,064 | -72 |
Accounts payable and accrued expenses | 4,279 | 1,001 |
Deferred revenue | 0 | -970 |
Deferred Rent | 525 | 1,961 |
Net cash used in operating activities | -26,411 | -18,361 |
Investing activities: | ' | ' |
Purchases of property and equipment, net | -2 | -89 |
Purchases of investments | -58,844 | -19,617 |
Proceeds from the sale and maturities of investments | 35,634 | 22,101 |
Net cash provided by (used in) investing activities | -23,212 | 2,395 |
Financing activities: | ' | ' |
Proceeds from issuance of common stock, net of offering costs | 37,754 | 16,120 |
Proceeds from Issuance of Long-term Debt | 12,699 | 0 |
Payments on notes payable | -1,464 | 0 |
Proceeds from issuance of common stock upon exercise of stock options | 783 | 42 |
Net cash provided by financing activities | 49,772 | 16,162 |
Net increase in cash and cash equivalents | 149 | 196 |
Cash and cash equivalents at beginning of period | 1,384 | 1,520 |
Cash and cash equivalents at end of period | 1,533 | ' |
Supplemental cash flow information | ' | ' |
Cash paid for interest | $1,188 | $778 |
Organization_and_Significant_A
Organization and Significant Accounting Policies | 6 Months Ended |
Jun. 30, 2014 | |
Organization and Significant Accounting Policies | ' |
Organization and Significant Accounting Policies | |
Organization | |
We are a biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market as well as orphan indications targeting inflammation, coagulopathies and disorders of the central nervous system. Derived from our proprietary PharmacoSurgery® platform, Omidria™ (phenylephrine and ketorolac injection) 1%/0.3%, our first drug product, was approved by the U.S. Food and Drug Administration (FDA) on May 30, 2014 for use during cataract surgery or intraocular lens replacement (ILR) to maintain pupil size by preventing intraoperative miosis (pupil constriction) and to reduce postoperative ocular pain. Our PharmacoSurgery platform, designed to improve clinical outcomes of patients undergoing ophthalmological, arthroscopic, urological and other surgical procedures, is based on low-dose combinations of FDA-approved therapeutic agents delivered directly to the surgical site throughout the duration of the procedure to inhibit preemptively inflammation and other problems caused by surgical trauma and to provide clinical benefits both during and after surgery. We have six clinical-stage development programs in our pipeline, which also includes a diverse group of preclinical programs as well as two additional platforms: one capable of unlocking new G protein-coupled receptor (GPCR) drug targets and the other used to generate antibodies. For Omidria and each of our product candidates and our programs, we have retained all manufacturing, marketing and distribution rights. | |
We have begun marketing Omidria in the U.S. and expect to begin selling Omidria in the U.S. in the fourth quarter of 2014. In September 2013, we submitted a Marketing Authorisation Application (MAA) to the European Medicines Agency (EMA) for Omidria and we expect a decision on the MAA in late 2014. Assuming approval of our MAA for Omidria by the EMA and partnering in Europe, we anticipate the initiation of marketing and sales of Omidria in the European Union (EU) in the first half of 2015. In the EU and other international territories, we plan to enter into one or more partnerships for the marketing and distribution of Omidria. | |
Basis of Presentation | |
Our consolidated financial statements include the financial position and results of operations of Omeros Corporation (Omeros) and our wholly owned subsidiaries. All inter-company transactions between and among our subsidiaries have been eliminated. The accompanying unaudited consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X. The information as of June 30, 2014 and for the three and six months ended June 30, 2014 and 2013 includes all adjustments, which include normal recurring adjustments, necessary to present fairly our interim financial information. The Consolidated Balance Sheet at December 31, 2013 has been derived from audited financial statements but does not include all of the information and footnotes required by GAAP. | |
The accompanying unaudited consolidated financial statements and notes to consolidated financial statements should be read in conjunction with the audited consolidated financial statements and related notes thereto that are included in our Annual Report on Form 10-K for the year ended December 31, 2013 filed with the Securities and Exchange Commission (SEC) on March 13, 2014. | |
Use of Estimates | |
The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Significant items subject to such estimates include revenue recognition, fair market value of investments, stock-based compensation expense and accruals for clinical trials and contingencies. We base our estimates on historical experience and on various other factors that we believe are reasonable under the circumstances; however, actual results could differ from these estimates. | |
Liquidity and Capital Resources | |
As of June 30, 2014, we had $37.5 million in cash, cash equivalents and short-term investments. We believe that our existing cash, cash equivalents and short-term investments, together with potential sales from Omidria and capital that we may be able to raise through one or more corporate partnerships, equity offerings, debt financings, collaborations, licensing arrangements or asset sales, will be sufficient to fund our anticipated operating expenses, capital expenditures and interest and principal payments on our outstanding notes for at least the next 12 months. | |
Inventory | |
Capitalization of costs as inventory begins when the product has received regulatory approval in the U.S. or the EU. We expense inventory costs related to product candidates as research and development expenses prior to regulatory approval in the respective territory. For Omidria, capitalization of costs as inventory began upon U.S. regulatory approval on May 30, 2014. We did not incur any Omidria inventory costs between May 31, 2014 and June 30, 2014. | |
Segments | |
We operate in one segment. Management uses cash flow as the primary measure to manage our business and does not segment our business for internal reporting or decision-making. | |
Recent Accounting Pronouncements | |
In May 2014, the Financial Accounting Standards Board issued an Accounting Standards Update, or ASU, related to the recognition of revenue that supersedes the prior guidance. This standard clarifies the principles for recognizing revenue utilizing a five-step process. This standard must be applied retroactively to each prior reporting period presented, or retrospectively with the cumulative effect of applying the standard recognized in the period adopted. We have not evaluated the impact on the financial statements once this standard is adopted. This standard is effective for interim and annual periods beginning after December 15, 2016. |
Net_Loss_Per_Share
Net Loss Per Share | 6 Months Ended | |||||
Jun. 30, 2014 | ||||||
Earnings Per Share [Abstract] | ' | |||||
Net Loss Per Share | ' | |||||
Net Loss Per Share | ||||||
Basic net loss per share is calculated by dividing the net loss by the weighted-average number of common shares outstanding for the period. Diluted net loss per share is computed by dividing the net loss by the weighted-average number of common shares and dilutive common share equivalents outstanding for the period, determined using the treasury-stock method. | ||||||
The basic and diluted net loss per share amounts for the three and six months ended June 30, 2014 and 2013 were computed based on the shares of common stock outstanding during the respective periods. Potentially dilutive securities excluded from the diluted loss per share calculation are as follows: | ||||||
June 30, | ||||||
2014 | 2013 | |||||
Outstanding options to purchase common stock | 6,814,963 | 5,308,861 | ||||
Warrants to purchase common stock | 609,016 | 609,016 | ||||
Total | 7,423,979 | 5,917,877 | ||||
Cash_Cash_Equivalents_and_Inve
Cash, Cash Equivalents and Investments | 6 Months Ended |
Jun. 30, 2014 | |
Cash and Cash Equivalents [Abstract] | ' |
Cash, Cash Equivalents and Investments | ' |
Cash, Cash Equivalents and Investments | |
As of June 30, 2014 and December 31, 2013, all investments are classified as short-term and available-for-sale on the accompanying Consolidated Balance Sheets. We did not own any securities with unrealized loss positions as of June 30, 2014 or December 31, 2013. Investment income consists primarily of interest income. |
FairValue_Measurements
Fair-Value Measurements | 6 Months Ended | |||||||||||||||
Jun. 30, 2014 | ||||||||||||||||
Fair Value Disclosures [Abstract] | ' | |||||||||||||||
Fair-Value Disclosures | ' | |||||||||||||||
Fair-Value Measurements | ||||||||||||||||
On a recurring basis, we measure certain financial assets at fair value. Fair value is defined as the exchange price that would be received for an asset or paid to transfer a liability, an exit price, in the principal or most advantageous market for the asset or liability in an orderly transaction between market participants on the measurement date. The accounting standard establishes a fair value hierarchy that requires an entity to maximize the use of observable inputs, where available. The following summarizes the three levels of inputs required: | ||||||||||||||||
Level 1—Observable inputs for identical assets or liabilities, such as quoted prices in active markets; | ||||||||||||||||
Level 2—Inputs other than quoted prices in active markets that are either directly or indirectly observable; and | ||||||||||||||||
Level 3—Unobservable inputs in which little or no market data exists, therefore developed using estimates and assumptions developed by us, which reflect those that a market participant would use. | ||||||||||||||||
Our fair-value hierarchy for our financial assets and liabilities measured at fair value on a recurring basis are as follows: | ||||||||||||||||
30-Jun-14 | ||||||||||||||||
Level 1 | Level 2 | Level 3 | Total | |||||||||||||
(In thousands) | ||||||||||||||||
Assets: | ||||||||||||||||
Money-market funds classified as non-current restricted cash | $ | 679 | $ | — | $ | — | $ | 679 | ||||||||
Money-market funds classified as short-term investments | 35,927 | — | — | 35,927 | ||||||||||||
Total | $ | 36,606 | $ | — | $ | — | $ | 36,606 | ||||||||
31-Dec-13 | ||||||||||||||||
Level 1 | Level 2 | Level 3 | Total | |||||||||||||
(In thousands) | ||||||||||||||||
Assets: | ||||||||||||||||
Money-market funds classified as cash equivalents | $ | 213 | $ | — | $ | — | $ | 213 | ||||||||
Money-market funds classified as non-current restricted cash | 679 | — | — | 679 | ||||||||||||
Money-market funds classified as short-term investments | 12,717 | — | — | 12,717 | ||||||||||||
Total | $ | 13,609 | $ | — | $ | — | $ | 13,609 | ||||||||
Cash held in demand deposit accounts of $1.5 million and $1.2 million is excluded from our fair-value hierarchy disclosure as of June 30, 2014 and December 31, 2013, respectively. There were no unrealized gains and losses associated with our short-term investments as of June 30, 2014 or December 31, 2013. The carrying amounts reported in the accompanying Consolidated Balance Sheets for grant and other receivables, accounts payable and other current monetary assets and liabilities approximate fair value because of the immediate or short-term maturity of these financial instruments. |
Accrued_Liabilities
Accrued Liabilities | 6 Months Ended | |||||||
Jun. 30, 2014 | ||||||||
Payables and Accruals [Abstract] | ' | |||||||
Accrued Liabilities | ' | |||||||
Accrued Liabilities | ||||||||
Accrued liabilities consisted of the following: | ||||||||
June 30, | December 31, | |||||||
2014 | 2013 | |||||||
(In thousands) | ||||||||
Contract research | $ | 1,844 | $ | 858 | ||||
Employee compensation | 1,368 | 1,346 | ||||||
Clinical trials | 751 | 596 | ||||||
Consulting & professional fees | 836 | 649 | ||||||
Other accruals | 677 | 495 | ||||||
Total accrued liabilities | $ | 5,476 | $ | 3,944 | ||||
Notes_Payable
Notes Payable | 6 Months Ended |
Jun. 30, 2014 | |
Debt Disclosure [Abstract] | ' |
Notes Payable | ' |
Notes Payable | |
In March 2014, we entered into a new Loan and Security Agreement (the Oxford/MidCap Loan Agreement) with Oxford Finance LLC (Oxford) and MidCap Financial SBIC, LP (MidCap) pursuant to which we borrowed $32.0 million. We used approximately $19.1 million of the loan proceeds to repay all of the amounts owed by us under our then outstanding loan from Oxford and, after deducting all loan initiation costs including a $160,000 upfront loan initiation fee and lenders’ legal costs, we received $12.7 million in net proceeds. The Oxford/MidCap Loan Agreement provides for monthly interest-only payments at an annual rate of 9.25% through March 1, 2015. Beginning April 1, 2015, monthly principal and interest payments of $1.0 million are due through the maturity date of March 1, 2018. In addition, the Oxford/MidCap Loan Agreement requires a $2.2 million loan maturity fee upon full repayment of the loan. We may prepay the outstanding principal balance in its entirety at any time if we pay an additional fee equal to 1.0% of the then-outstanding principal balance, which prepayment fee would be waived if we refinance the indebtedness with Oxford and MidCap and pay the loan maturity fee. As security under the Oxford/MidCap Loan Agreement, we granted Oxford, as collateral agent for the lenders, a security interest in substantially all of our assets, excluding intellectual property. | |
The Oxford/MidCap Loan Agreement contains covenants that limit or restrict our ability to incur indebtedness, grant liens, merge or consolidate, dispose of assets, make investments, make acquisitions, enter into certain transactions with affiliates, pay dividends or make distributions, pledge our intellectual property or repurchase stock. Additionally, the Oxford/MidCap Loan Agreement includes events of default regarding non-payment, inaccuracy of representations and warranties, covenant breach, occurrence of a material adverse effect (MAE, as defined below), cross default to material indebtedness, bankruptcy or insolvency, material judgment defaults and a change of control. The occurrence of an event of default could result in the acceleration of the Oxford/MidCap Loan Agreement and, under certain circumstances, could increase our interest rate 5.0% per annum during the period of default. | |
MAE is defined as a material adverse effect upon (i) our business operations, properties, assets, results of operations or financial condition of Omeros, taken as a whole with respect to our viability, that reasonably would be expected to result in our inability to repay any portion of the loans in accordance with the terms of the Oxford/MidCap Loan Agreement, (ii) the validity, perfection, value or priority of the lenders’ security interest in the collateral, (iii) the enforceability of any material provision of the Oxford/MidCap Loan Agreement or related agreements, or (iv) the ability of the lenders to enforce its rights and remedies under the Oxford/MidCap Loan Agreement or related agreements. | |
We accounted for the Oxford/MidCap Loan Agreement as a debt modification and, accordingly, the remaining unamortized debt issuance costs of $103,000 associated with the then outstanding loan with Oxford and the debt issuance costs of $244,000 associated with the Oxford/MidCap Loan Agreement are being amortized to interest expense using the effective interest method through the March 1, 2018 Oxford/MidCap Loan Agreement maturity date. Additionally, the $2.2 million maturity fee, which is treated as a debt discount, is being amortized to interest expense using the effective-interest method through March 1, 2018. | |
As of June 30, 2014, the remaining unamortized discount and debt issuance costs associated with the debt were $2.0 million and $312,000, respectively. |
Revenue
Revenue | 6 Months Ended | |||||||||||||||
Jun. 30, 2014 | ||||||||||||||||
Text Block [Abstract] | ' | |||||||||||||||
Revenue | ' | |||||||||||||||
Revenue | ||||||||||||||||
Revenue recognized from grants and other sources is as follows: | ||||||||||||||||
Three Months Ended | Six Months Ended | |||||||||||||||
June 30, | June 30, | |||||||||||||||
2014 | 2013 | 2014 | 2013 | |||||||||||||
(In thousands) | ||||||||||||||||
Small Business Innovative Research Grants | $ | 45 | $ | 140 | $ | 145 | $ | 265 | ||||||||
Vulcan Inc. | $ | — | $ | — | $ | — | $ | 970 | ||||||||
Total revenue | $ | 45 | $ | 140 | $ | 145 | $ | 1,235 | ||||||||
We have periodically received Small Business Innovative Research (SBIR) grants from the National Institutes of Health (NIH), which are used to support the research and development of our product candidates. We recorded revenue related to these grants of $45,000 and $140,000 for the three months ended June 30, 2014 and 2013, respectively, and $145,000 and $1.2 million for the six months ended June 30, 2014 and 2013, respectively. As of June 30, 2014, $1.1 million of potential revenue remained available under these grants, if qualifying research is performed. | ||||||||||||||||
In October 2010, we entered into a platform development funding agreement with Vulcan Inc. and its affiliate (collectively, Vulcan) pursuant to which we received $20.0 million for our G protein-coupled receptor (GPCR) program. Of the funds received, $8.2 million was recorded as deferred revenue. The remaining deferred revenue of $970,000 was recognized as revenue during the first quarter of 2013. |
Commitments_and_Contingencies
Commitments and Contingencies | 6 Months Ended |
Jun. 30, 2014 | |
Commitments and Contingencies Disclosure [Abstract] | ' |
Commitments and Contingencies | ' |
Commitments and Contingencies | |
Real Estate Obligations | |
We lease our office and laboratory space in The Omeros Building under a lease agreement with BMR-201 Elliott Avenue LLC (BMR). The initial term of the lease ends in November 2027 and we have two options to extend the lease term, each by five years. As of June 30, 2014, the remaining aggregate non-cancelable rent payable under the initial term of the lease is approximately $60.2 million. The deferred rent balance relates to rent deferrals since the inception of our lease. Deferred rent is being amortized to research and development and selling, general and administrative expense on a straight-line basis through the term of the lease. | |
Contracts | |
In June 2014, we entered into an agreement with Ventiv Commercial Services, LLC (inVentiv) for field sales representatives and related sales operation services for the commercial launch of Omidria in the U.S. As of June 30, 2014, we have paid the implementation fee of $308,000 of which $205,000 was recorded as selling, general and administrative expense. The remaining $103,000 is recorded as a prepaid expense in the Consolidated Balance Sheet at June 30, 2014. As of June 30, 2014, we did not have any non-cancellable amounts due under the agreement other than the implementation fee. Beginning at the time of deployment of the sales force in August 2014, we will begin incurring a non-cancellable monthly fee of approximately $300,000 for the first 12 months of services. We can terminate the agreement subsequent to the 18-month anniversary of the deployment date. | |
We have an agreement with Patheon Manufacturing Services LLC (Patheon) for the commercial supply of Omidria through December 31, 2015. Pursuant to the terms of the contract, we are required to provide a monthly, non-binding production forecast covering the term of the contract to Patheon. Upon submission of the monthly forecast, a portion of the forecast becomes a firm purchase commitment. In the event we do not purchase the quantities included in the firm purchase commitment, we would owe a cancellation fee. | |
Development Milestones and Product Royalties | |
We have retained worldwide commercial rights to Omidria and all of our product candidates in our clinical and preclinical programs. We potentially owe certain development milestones and sales based royalties on commercial sales of certain product candidates within our pipeline. These are low-single-digit royalties based on net sales or net income as more fully described in our 2013 Annual Report on Form 10-K filed with the SEC on March 13, 2014. | |
During the first quarter of 2014, we incurred a milestone payment of $200,000 to Helion Biotech ApS (Helion) related to the filing of an Investigational New Drug Application (IND) with the FDA for our mannan-binding lectin-associated serine protease-2 (MASP-2) program. | |
Other | |
In the first quarter of 2013, we recorded a $900,000 expense as selling, general and administrative expense in connection with previously awarded NIH grants. |
Shareholders_Equity
Shareholders' Equity | 6 Months Ended | ||||
Jun. 30, 2014 | |||||
Equity [Abstract] | ' | ||||
Shareholders' Equity | ' | ||||
Shareholders’ Equity | |||||
Common Stock | |||||
Public Offering - In March 2014, we sold 3.5 million shares of our common stock at a public offering price of $11.50 per share. After deducting offering expenses and underwriter discounts of $2.5 million, we received net proceeds from the transaction of $37.8 million. | |||||
Warrants | |||||
The following table summarizes our total outstanding warrants as of June 30, 2014, which have a weighted average exercise price of $23.85: | |||||
Outstanding At | Expiration Date | Exercise Price | |||
30-Jun-14 | |||||
197,478 | September 29, 2014 | $12.25 | |||
133,333 | October 21, 2015 | 20 | |||
133,333 | October 21, 2015 | 30 | |||
133,333 | October 21, 2015 | 40 | |||
11,539 | April 26, 2015 | 9.13 | |||
609,016 | |||||
On March 28, 2014, we extended the expiration dates of warrants to purchase 197,478 shares of our common stock at an exercise price of $12.25 per share to September 29, 2014. In March 2013, we had extended the expiration dates of the same warrants by one year. We evaluated the fair value of the warrants before and after the modifications and recorded the $452,000 and $41,000 change in fair value as other expense in the accompanying Consolidated Statement of Operations and Comprehensive Loss for the six months ended June 30, 2014 and 2013, respectively. | |||||
In October 2010, in connection with the Vulcan agreement, we issued to Vulcan three warrants to purchase our common stock, each exercisable for 133,333 shares, with exercise prices of $20, $30 and $40 per share, respectively. |
StockBased_Compensation
Stock-Based Compensation | 6 Months Ended | |||||||||||||||
Jun. 30, 2014 | ||||||||||||||||
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] | ' | |||||||||||||||
Stock-Based Compensation | ' | |||||||||||||||
Stock-Based Compensation | ||||||||||||||||
Our 2008 Equity Incentive Plan (the 2008 Plan) provides for the grant of incentive and nonstatutory stock options, restricted stock, stock appreciation rights, performance units and performance shares to employees, directors and consultants and subsidiary corporations’ employees and consultants. Options are granted with exercise prices equal to the closing fair market value of our common stock on the date of the grant. The terms of options may not exceed 10 years and options generally vest over a four-year period. | ||||||||||||||||
On January 1, 2014, in accordance with provisions of the 2008 Plan, the authorized shares available for grant under the 2008 Plan were increased by 1,517,975 shares. As of June 30, 2014, a total of 8,765,684 shares were reserved for issuance under our stock plans, of which 1,950,721 were available for future grants under the 2008 Plan. | ||||||||||||||||
The fair value of each option grant is estimated on the date of grant using the Black-Scholes option-pricing model. The following assumptions were applied to stock option grants during the periods ended: | ||||||||||||||||
Three Months Ended | Six Months Ended | |||||||||||||||
June 30, | June 30, | |||||||||||||||
2014 | 2013 | 2014 | 2013 | |||||||||||||
Estimated weighted-average fair value | $ | 8.2 | $ | 3.57 | $ | 8.2 | $ | 3.57 | ||||||||
Weighted-average assumptions | ||||||||||||||||
Expected volatility | 80 | % | 82 | % | 80 | % | 82 | % | ||||||||
Expected term, in years | 5.9 | 5.5 | 5.9 | 5.5 | ||||||||||||
Risk-free interest rate | 1.88 | % | 1.02 | % | 1.88 | % | 1.02 | % | ||||||||
Expected dividend yield | — | % | — | % | — | % | — | % | ||||||||
Stock-based compensation expense has been reported in our Consolidated Statements of Operations and Comprehensive Loss as follows: | ||||||||||||||||
Three Months Ended | Six Months Ended | |||||||||||||||
June 30, | June 30, | |||||||||||||||
2014 | 2013 | 2014 | 2013 | |||||||||||||
(In thousands) | (In thousands) | |||||||||||||||
Research and development | $ | 901 | $ | 566 | $ | 1,911 | $ | 1,147 | ||||||||
Selling, general and administrative | 729 | 494 | 1,506 | 1,006 | ||||||||||||
Total | $ | 1,630 | $ | 1,060 | $ | 3,417 | $ | 2,153 | ||||||||
Stock option activity for all stock plans and related information is as follows: | ||||||||||||||||
Options | Weighted- | Remaining | Aggregate | |||||||||||||
Outstanding | Average | Contractual Life | Intrinsic | |||||||||||||
Exercise | (In years) | Value | ||||||||||||||
Price per | (In thousands) | |||||||||||||||
Share | ||||||||||||||||
Balance at December 31, 2013 | 6,969,303 | $ | 6.38 | |||||||||||||
Granted | 166,750 | 11.73 | ||||||||||||||
Exercised | (134,924 | ) | 5.8 | |||||||||||||
Forfeited | (186,166 | ) | 9.9 | |||||||||||||
Balance at June 30, 2014 | 6,814,963 | $ | 6.42 | 6.71 | $ | 74,811 | ||||||||||
Vested and expected to vest at June 30, 2014 | 6,582,978 | $ | 6.32 | 6.63 | $ | 72,938 | ||||||||||
Exercisable at June 30, 2014 | 4,496,727 | $ | 4.94 | 5.62 | $ | 56,014 | ||||||||||
At June 30, 2014, there were 2,318,236 unvested options outstanding that will vest over a weighted-average period of 2.2 years. Excluding non-employee stock options, the total estimated compensation expense to be recognized in connection with these options is $12.5 million. |
Organization_and_Significant_A1
Organization and Significant Accounting Policies (Policies) | 6 Months Ended |
Jun. 30, 2014 | |
Organization | ' |
Organization | |
We are a biopharmaceutical company committed to discovering, developing and commercializing small-molecule and protein therapeutics for large-market as well as orphan indications targeting inflammation, coagulopathies and disorders of the central nervous system. Derived from our proprietary PharmacoSurgery® platform, Omidria™ (phenylephrine and ketorolac injection) 1%/0.3%, our first drug product, was approved by the U.S. Food and Drug Administration (FDA) on May 30, 2014 for use during cataract surgery or intraocular lens replacement (ILR) to maintain pupil size by preventing intraoperative miosis (pupil constriction) and to reduce postoperative ocular pain. Our PharmacoSurgery platform, designed to improve clinical outcomes of patients undergoing ophthalmological, arthroscopic, urological and other surgical procedures, is based on low-dose combinations of FDA-approved therapeutic agents delivered directly to the surgical site throughout the duration of the procedure to inhibit preemptively inflammation and other problems caused by surgical trauma and to provide clinical benefits both during and after surgery. We have six clinical-stage development programs in our pipeline, which also includes a diverse group of preclinical programs as well as two additional platforms: one capable of unlocking new G protein-coupled receptor (GPCR) drug targets and the other used to generate antibodies. For Omidria and each of our product candidates and our programs, we have retained all manufacturing, marketing and distribution rights. | |
We have begun marketing Omidria in the U.S. and expect to begin selling Omidria in the U.S. in the fourth quarter of 2014. In September 2013, we submitted a Marketing Authorisation Application (MAA) to the European Medicines Agency (EMA) for Omidria and we expect a decision on the MAA in late 2014. Assuming approval of our MAA for Omidria by the EMA and partnering in Europe, we anticipate the initiation of marketing and sales of Omidria in the European Union (EU) in the first half of 2015. In the EU and other international territories, we plan to enter into one or more partnerships for the marketing and distribution of Omidria. | |
Basis of Presentation | ' |
Basis of Presentation | |
Our consolidated financial statements include the financial position and results of operations of Omeros Corporation (Omeros) and our wholly owned subsidiaries. All inter-company transactions between and among our subsidiaries have been eliminated. The accompanying unaudited consolidated financial statements have been prepared in accordance with U.S. generally accepted accounting principles (GAAP) for interim financial information and with the instructions to Form 10-Q and Rule 10-01 of Regulation S-X. The information as of June 30, 2014 and for the three and six months ended June 30, 2014 and 2013 includes all adjustments, which include normal recurring adjustments, necessary to present fairly our interim financial information. The Consolidated Balance Sheet at December 31, 2013 has been derived from audited financial statements but does not include all of the information and footnotes required by GAAP. | |
The accompanying unaudited consolidated financial statements and notes to consolidated financial statements should be read in conjunction with the audited consolidated financial statements and related notes thereto that are included in our Annual Report on Form 10-K for the year ended December 31, 2013 filed with the Securities and Exchange Commission (SEC) on March 13, 2014. | |
Use of Estimates | ' |
Use of Estimates | |
The preparation of financial statements in conformity with GAAP requires management to make estimates and assumptions that affect the amounts reported in the financial statements and accompanying notes. Significant items subject to such estimates include revenue recognition, fair market value of investments, stock-based compensation expense and accruals for clinical trials and contingencies. We base our estimates on historical experience and on various other factors that we believe are reasonable under the circumstances; however, actual results could differ from these estimates. | |
Liquidity Disclosure [Policy Text Block] | ' |
Liquidity and Capital Resources | |
As of June 30, 2014, we had $37.5 million in cash, cash equivalents and short-term investments. We believe that our existing cash, cash equivalents and short-term investments, together with potential sales from Omidria and capital that we may be able to raise through one or more corporate partnerships, equity offerings, debt financings, collaborations, licensing arrangements or asset sales, will be sufficient to fund our anticipated operating expenses, capital expenditures and interest and principal payments on our outstanding notes for at least the next 12 months. | |
Inventory, Policy [Policy Text Block] | ' |
Inventory | |
Capitalization of costs as inventory begins when the product has received regulatory approval in the U.S. or the EU. We expense inventory costs related to product candidates as research and development expenses prior to regulatory approval in the respective territory. For Omidria, capitalization of costs as inventory began upon U.S. regulatory approval on May 30, 2014. We did not incur any Omidria inventory costs between May 31, 2014 and June 30, 2014. | |
Segments | ' |
Segments | |
We operate in one segment. Management uses cash flow as the primary measure to manage our business and does not segment our business for internal reporting or decision-making. | |
New Accounting Pronouncements and Changes in Accounting Principles [Text Block] | ' |
Recent Accounting Pronouncements | |
In May 2014, the Financial Accounting Standards Board issued an Accounting Standards Update, or ASU, related to the recognition of revenue that supersedes the prior guidance. This standard clarifies the principles for recognizing revenue utilizing a five-step process. This standard must be applied retroactively to each prior reporting period presented, or retrospectively with the cumulative effect of applying the standard recognized in the period adopted. We have not evaluated the impact on the financial statements once this standard is adopted. This standard is effective for interim and annual periods beginning after December 15, 2016. |
Net_Loss_Per_Share_Tables
Net Loss Per Share (Tables) | 6 Months Ended | |||||
Jun. 30, 2014 | ||||||
Earnings Per Share [Abstract] | ' | |||||
Calculation of Historical Outstanding Dilutive Securities Not Included in Diluted Loss per Share | ' | |||||
Potentially dilutive securities excluded from the diluted loss per share calculation are as follows: | ||||||
June 30, | ||||||
2014 | 2013 | |||||
Outstanding options to purchase common stock | 6,814,963 | 5,308,861 | ||||
Warrants to purchase common stock | 609,016 | 609,016 | ||||
Total | 7,423,979 | 5,917,877 | ||||
FairValue_Measurements_Tables
Fair-Value Measurements (Tables) | 6 Months Ended | |||||||||||||||
Jun. 30, 2014 | ||||||||||||||||
Fair Value Disclosures [Abstract] | ' | |||||||||||||||
Financial Assets and Liabilities Measured at Fair Value on Recurring Basis | ' | |||||||||||||||
Our fair-value hierarchy for our financial assets and liabilities measured at fair value on a recurring basis are as follows: | ||||||||||||||||
30-Jun-14 | ||||||||||||||||
Level 1 | Level 2 | Level 3 | Total | |||||||||||||
(In thousands) | ||||||||||||||||
Assets: | ||||||||||||||||
Money-market funds classified as non-current restricted cash | $ | 679 | $ | — | $ | — | $ | 679 | ||||||||
Money-market funds classified as short-term investments | 35,927 | — | — | 35,927 | ||||||||||||
Total | $ | 36,606 | $ | — | $ | — | $ | 36,606 | ||||||||
31-Dec-13 | ||||||||||||||||
Level 1 | Level 2 | Level 3 | Total | |||||||||||||
(In thousands) | ||||||||||||||||
Assets: | ||||||||||||||||
Money-market funds classified as cash equivalents | $ | 213 | $ | — | $ | — | $ | 213 | ||||||||
Money-market funds classified as non-current restricted cash | 679 | — | — | 679 | ||||||||||||
Money-market funds classified as short-term investments | 12,717 | — | — | 12,717 | ||||||||||||
Total | $ | 13,609 | $ | — | $ | — | $ | 13,609 | ||||||||
Accrued_Liabilities_Tables
Accrued Liabilities (Tables) | 6 Months Ended | |||||||
Jun. 30, 2014 | ||||||||
Payables and Accruals [Abstract] | ' | |||||||
Accrued Liabilities | ' | |||||||
Accrued liabilities consisted of the following: | ||||||||
June 30, | December 31, | |||||||
2014 | 2013 | |||||||
(In thousands) | ||||||||
Contract research | $ | 1,844 | $ | 858 | ||||
Employee compensation | 1,368 | 1,346 | ||||||
Clinical trials | 751 | 596 | ||||||
Consulting & professional fees | 836 | 649 | ||||||
Other accruals | 677 | 495 | ||||||
Total accrued liabilities | $ | 5,476 | $ | 3,944 | ||||
Revenue_Revenue_by_Agreement_T
Revenue Revenue by Agreement (Tables) | 6 Months Ended | |||||||||||||||
Jun. 30, 2014 | ||||||||||||||||
Revenue Recognition [Abstract] | ' | |||||||||||||||
Revenue Recognition, Multiple-deliverable Arrangements, Description | ' | |||||||||||||||
Revenue recognized from grants and other sources is as follows: | ||||||||||||||||
Three Months Ended | Six Months Ended | |||||||||||||||
June 30, | June 30, | |||||||||||||||
2014 | 2013 | 2014 | 2013 | |||||||||||||
(In thousands) | ||||||||||||||||
Small Business Innovative Research Grants | $ | 45 | $ | 140 | $ | 145 | $ | 265 | ||||||||
Vulcan Inc. | $ | — | $ | — | $ | — | $ | 970 | ||||||||
Total revenue | $ | 45 | $ | 140 | $ | 145 | $ | 1,235 | ||||||||
Shareholders_Equity_Tables
Shareholders' Equity (Tables) | 6 Months Ended | ||||
Jun. 30, 2014 | |||||
Equity [Abstract] | ' | ||||
Schedule of Stockholders' Equity Note, Warrants or Rights | ' | ||||
The following table summarizes our total outstanding warrants as of June 30, 2014, which have a weighted average exercise price of $23.85: | |||||
Outstanding At | Expiration Date | Exercise Price | |||
30-Jun-14 | |||||
197,478 | September 29, 2014 | $12.25 | |||
133,333 | October 21, 2015 | 20 | |||
133,333 | October 21, 2015 | 30 | |||
133,333 | October 21, 2015 | 40 | |||
11,539 | April 26, 2015 | 9.13 | |||
609,016 |
StockBased_Compensation_Tables
Stock-Based Compensation (Tables) | 6 Months Ended | |||||||||||||||
Jun. 30, 2014 | ||||||||||||||||
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] | ' | |||||||||||||||
Stock-Based Compensation Expense | ' | |||||||||||||||
Stock-based compensation expense has been reported in our Consolidated Statements of Operations and Comprehensive Loss as follows: | ||||||||||||||||
Three Months Ended | Six Months Ended | |||||||||||||||
June 30, | June 30, | |||||||||||||||
2014 | 2013 | 2014 | 2013 | |||||||||||||
(In thousands) | (In thousands) | |||||||||||||||
Research and development | $ | 901 | $ | 566 | $ | 1,911 | $ | 1,147 | ||||||||
Selling, general and administrative | 729 | 494 | 1,506 | 1,006 | ||||||||||||
Total | $ | 1,630 | $ | 1,060 | $ | 3,417 | $ | 2,153 | ||||||||
Stock Option Activity and Related Information | ' | |||||||||||||||
Stock option activity for all stock plans and related information is as follows: | ||||||||||||||||
Options | Weighted- | Remaining | Aggregate | |||||||||||||
Outstanding | Average | Contractual Life | Intrinsic | |||||||||||||
Exercise | (In years) | Value | ||||||||||||||
Price per | (In thousands) | |||||||||||||||
Share | ||||||||||||||||
Balance at December 31, 2013 | 6,969,303 | $ | 6.38 | |||||||||||||
Granted | 166,750 | 11.73 | ||||||||||||||
Exercised | (134,924 | ) | 5.8 | |||||||||||||
Forfeited | (186,166 | ) | 9.9 | |||||||||||||
Balance at June 30, 2014 | 6,814,963 | $ | 6.42 | 6.71 | $ | 74,811 | ||||||||||
Vested and expected to vest at June 30, 2014 | 6,582,978 | $ | 6.32 | 6.63 | $ | 72,938 | ||||||||||
Exercisable at June 30, 2014 | 4,496,727 | $ | 4.94 | 5.62 | $ | 56,014 | ||||||||||
Organization_and_Significant_A2
Organization and Significant Accounting Policies (Detail) (USD $) | 3 Months Ended |
In Millions, unless otherwise specified | Jun. 30, 2014 |
segment | |
Accounting Policies [Abstract] | ' |
Cash, Cash Equivalents, and Short-term Investments | $37.50 |
Number of operating segments | 1 |
Net_Loss_Per_Share_Calculation
Net Loss Per Share - Calculation of Historical Outstanding Dilutive Securities Not Included in Diluted Loss Per Share (Detail) | 6 Months Ended | |
Jun. 30, 2014 | Jun. 30, 2013 | |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ' | ' |
Outstanding dilutive securities not included in diluted loss per share calculation | 7,423,979 | 5,917,877 |
Outstanding options to purchase common stock | ' | ' |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ' | ' |
Outstanding dilutive securities not included in diluted loss per share calculation | 6,814,963 | 5,308,861 |
Warrants to purchase common stock | ' | ' |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | ' | ' |
Outstanding dilutive securities not included in diluted loss per share calculation | 609,016 | 609,016 |
FairValue_Measurements_Financi
Fair-Value Measurements - Financial Assets and Liabilities Measured at Fair Value on Recurring Basis (Detail) (Fair Value, Measurements, Recurring, USD $) | Jun. 30, 2014 | Dec. 31, 2013 |
In Thousands, unless otherwise specified | ||
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items] | ' | ' |
Total | $36,606 | $13,609 |
Money Market Funds | ' | ' |
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items] | ' | ' |
Money-market funds classified as cash equivalents | ' | 213 |
Money-market funds classified as short-term investments | 35,927 | 12,717 |
Non Current | ' | ' |
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items] | ' | ' |
Money-market funds classified as restricted cash | 679 | 679 |
Fair Value, Inputs, Level 1 | ' | ' |
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items] | ' | ' |
Total | 36,606 | 13,609 |
Fair Value, Inputs, Level 1 | Money Market Funds | ' | ' |
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items] | ' | ' |
Money-market funds classified as cash equivalents | ' | 213 |
Money-market funds classified as short-term investments | 35,927 | 12,717 |
Fair Value, Inputs, Level 1 | Non Current | ' | ' |
Fair Value, Assets and Liabilities Measured on Recurring Basis [Line Items] | ' | ' |
Money-market funds classified as restricted cash | $679 | $679 |
FairValue_Measurements_Narrati
Fair-Value Measurements - Narrative (Detail) (USD $) | 6 Months Ended | 12 Months Ended |
Jun. 30, 2014 | Dec. 31, 2013 | |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ' | ' |
Cash excluded from fair value hierarchy disclosure | $1,500,000 | $1,200,000 |
Unrealized Gain (Loss) on Investments | $0 | $0 |
Accrued_Liabilities_Accrued_Li
Accrued Liabilities - Accrued Liabilities (Detail) (USD $) | Jun. 30, 2014 | Dec. 31, 2013 |
In Thousands, unless otherwise specified | ||
Payables and Accruals [Abstract] | ' | ' |
Contract research | $1,844 | $858 |
Employee compensation | 1,368 | 1,346 |
Clinical trials | 751 | 596 |
Consulting & professional fees | 836 | 649 |
Other accruals | 677 | 495 |
Total accrued liabilities | $5,476 | $3,944 |
Notes_Payable_Detail
Notes Payable (Detail) (USD $) | 6 Months Ended | 3 Months Ended | 6 Months Ended | 2 Months Ended | ||
Jun. 30, 2014 | Jun. 30, 2013 | Mar. 31, 2014 | Jun. 30, 2014 | Mar. 04, 2014 | Mar. 04, 2014 | |
Oxford Midcap Loan [Member] | Oxford Midcap Loan [Member] | Oxford Midcap Loan [Member] | Oxford Loan Agreement [Member] | |||
Debt Instrument [Line Items] | ' | ' | ' | ' | ' | ' |
Loan and security agreement, existing outstanding indebtedness | ' | ' | ' | ' | $32,000,000 | ' |
Repayments of Debt | ' | ' | 19,100,000 | ' | ' | ' |
Payments of Debt Restructuring Costs | ' | ' | 160,000 | ' | ' | ' |
Proceeds from Issuance of Long-term Debt | 12,699,000 | 0 | 12,699,000 | ' | ' | ' |
Accrued interest rate | ' | ' | ' | 9.25% | ' | ' |
Debt Instrument, Date of First Required Payment | ' | ' | ' | 1-Apr-15 | ' | ' |
Debt Instrument, Periodic Payment | ' | ' | ' | 1,021,000 | ' | ' |
Debt Instrument, Fee Amount | ' | ' | ' | 2,200,000 | ' | ' |
Debt Prepayment Penalty Rate | ' | ' | ' | 1.00% | ' | ' |
Additional Default Interest Rate | ' | ' | ' | 5.00% | ' | ' |
Debt Issuance Cost | ' | ' | 244,000 | ' | ' | 103,000 |
Unamortized balance of debt discount | ' | ' | ' | 2,024,000 | ' | ' |
Unamortized balance of debt issuance costs | ' | ' | ' | $312,000 | ' | ' |
Revenue_Detail
Revenue (Detail) (USD $) | 1 Months Ended | 3 Months Ended | 6 Months Ended | ||
Oct. 31, 2010 | Jun. 30, 2014 | Jun. 30, 2013 | Jun. 30, 2014 | Jun. 30, 2013 | |
Revenue [Line Items] | ' | ' | ' | ' | ' |
Revenue | ' | $45,000 | $140,000 | $145,000 | $1,235,000 |
Small Business Innovative Research | ' | ' | ' | ' | ' |
Revenue [Line Items] | ' | ' | ' | ' | ' |
Grant revenue recognized | ' | 45,000 | 140,000 | 145,000 | 265,000 |
Remaining available amount under grant | ' | 1,062,000 | ' | 1,062,000 | ' |
Vulcan Incorporated | ' | ' | ' | ' | ' |
Revenue [Line Items] | ' | ' | ' | ' | ' |
Grants received | 20,000,000 | ' | ' | ' | ' |
Deferred revenue | 8,200,000 | ' | ' | ' | ' |
Deferred Revenue, Revenue Recognized | ' | $0 | $0 | $0 | $970,000 |
Commitments_and_Contingencies_
Commitments and Contingencies (Detail) (USD $) | 3 Months Ended | 6 Months Ended | |||
Jun. 30, 2014 | Jun. 30, 2013 | Jun. 30, 2014 | Jun. 30, 2013 | Dec. 31, 2013 | |
Leases | |||||
Commitments and Contingencies Disclosure [Line Items] | ' | ' | ' | ' | ' |
Number of Options to extend the lease term | ' | ' | 2 | ' | ' |
Options to extend the lease term, number of options | ' | ' | '5 years | ' | ' |
Remaining aggregate rent payable | $60,200,000 | ' | $60,200,000 | ' | ' |
Prepaid expenses | 1,110,000 | ' | 1,110,000 | ' | 251,000 |
Research and development expense | 12,407,000 | 9,564,000 | 24,424,000 | 16,691,000 | ' |
Selling, General and Administrative Expenses | ' | ' | ' | ' | ' |
Commitments and Contingencies Disclosure [Line Items] | ' | ' | ' | ' | ' |
Government Grants Under Review | ' | ' | ' | 900,000 | ' |
InVentiv [Member] | ' | ' | ' | ' | ' |
Commitments and Contingencies Disclosure [Line Items] | ' | ' | ' | ' | ' |
Purchase Obligation | 308,000 | ' | 308,000 | ' | ' |
Selling, General and Administrative Expense | 205,000 | ' | ' | ' | ' |
Prepaid expenses | 103,000 | ' | 103,000 | ' | ' |
Recorded Unconditional Purchase Obligation, Due in Remainder of Fiscal Year | 300,000 | ' | 300,000 | ' | ' |
Helion Biotech ApS | ' | ' | ' | ' | ' |
Commitments and Contingencies Disclosure [Line Items] | ' | ' | ' | ' | ' |
Research and development expense | $200,000 | ' | ' | ' | ' |
Shareholders_Equity_Detail
Shareholders' Equity (Detail) (USD $) | 1 Months Ended | 3 Months Ended | 6 Months Ended | ||
Oct. 31, 2010 | Jun. 30, 2014 | Jun. 30, 2014 | Jun. 30, 2013 | Mar. 29, 2007 | |
warrant | |||||
Class of Stock [Line Items] | ' | ' | ' | ' | ' |
Stock Issued During Period, Shares, New Issues | ' | 3,500,000 | ' | ' | ' |
Share Price | ' | $11.50 | $11.50 | ' | ' |
Payments of Stock Issuance Costs | ' | $2,500,000 | ' | ' | ' |
Proceeds from issuance of common stock, net of offering costs | ' | ' | 37,754,000 | 16,120,000 | ' |
Shares of common stock to purchase by warrant | ' | 197,478 | 197,478 | ' | 197,478 |
Warrant expiration date | ' | ' | 29-Sep-14 | ' | ' |
Warrant Extension Period | ' | ' | '1 year | ' | ' |
Exercise price of warrants | ' | $12.25 | $12.25 | ' | $12.25 |
Class of Warrant or Right, Outstanding | ' | 609,016 | 609,016 | ' | ' |
Class of Warrant or Right, Exercise Price of Warrants or Rights, Weighted Average Price | ' | 23.85 | 23.85 | ' | ' |
Change in fair value of warrants | ' | ' | $452,000 | $41,000 | ' |
Number of warrants issued | 3 | ' | ' | ' | ' |
Oxford [Member] | ' | ' | ' | ' | ' |
Class of Stock [Line Items] | ' | ' | ' | ' | ' |
Shares of common stock to purchase by warrant | ' | 11,539 | 11,539 | ' | ' |
Warrant expiration date | ' | ' | 26-Apr-15 | ' | ' |
Exercise price of warrants | ' | $9.13 | $9.13 | ' | ' |
Warrant One | Vulcan Incorporated | ' | ' | ' | ' | ' |
Class of Stock [Line Items] | ' | ' | ' | ' | ' |
Shares of common stock to purchase by warrant | 133,333 | 133,333 | 133,333 | ' | ' |
Warrant expiration date | ' | ' | 21-Oct-15 | ' | ' |
Exercise price of warrants | 20 | $20 | $20 | ' | ' |
Warrant Two | Vulcan Incorporated | ' | ' | ' | ' | ' |
Class of Stock [Line Items] | ' | ' | ' | ' | ' |
Shares of common stock to purchase by warrant | ' | 133,333 | 133,333 | ' | ' |
Warrant expiration date | ' | ' | 21-Oct-15 | ' | ' |
Exercise price of warrants | 30 | $30 | $30 | ' | ' |
Warrant Three | Vulcan Incorporated | ' | ' | ' | ' | ' |
Class of Stock [Line Items] | ' | ' | ' | ' | ' |
Shares of common stock to purchase by warrant | ' | 133,333 | 133,333 | ' | ' |
Warrant expiration date | ' | ' | 21-Oct-15 | ' | ' |
Exercise price of warrants | 40 | $40 | $40 | ' | ' |
StockBased_Compensation_Narrat
Stock-Based Compensation - Narrative (Detail) (USD $) | 3 Months Ended | 6 Months Ended | 3 Months Ended | 1 Months Ended | 3 Months Ended | ||
In Millions, except Share data, unless otherwise specified | Jun. 30, 2014 | Jun. 30, 2013 | Jun. 30, 2014 | Jun. 30, 2013 | Jun. 30, 2014 | Jan. 31, 2013 | Jun. 30, 2014 |
Equity Incentive Plan 2008 | Equity Incentive Plan 2008 | Equity Incentive Plan 2008 | |||||
Stock Option | Maximum | ||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | ' | ' | ' | ' | ' | ' | ' |
Stock options, maximum term | '5 years 11 months 4 days | '5 years 6 months | '5 years 11 months 4 days | '5 years 6 months | ' | ' | '10 years |
Stock options, average vesting period | ' | ' | ' | ' | '4 years | ' | ' |
Increase in authorized shares | ' | ' | ' | ' | ' | 1,517,975 | ' |
Stock options, number of shares reserved for issuance | ' | ' | ' | ' | 8,765,684 | ' | ' |
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant | ' | ' | ' | ' | 1,950,721 | ' | ' |
Unvested options outstanding | 2,318,236 | ' | 2,318,236 | ' | ' | ' | ' |
Unvested options outstanding, vesting period | ' | ' | '2 years 2 months 15 days | ' | ' | ' | ' |
Unrecognized compensation expense | $12.50 | ' | $12.50 | ' | ' | ' | ' |
StockBased_Compensation_Fair_V
Stock-Based Compensation Fair Value of Employee Option Grant Estimated on Date of Grant (Details) (USD $) | 3 Months Ended | 6 Months Ended | ||
Jun. 30, 2014 | Jun. 30, 2013 | Jun. 30, 2014 | Jun. 30, 2013 | |
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] | ' | ' | ' | ' |
Share-based Compensation Arrangement by Share-based Payment Award, Options, Grants in Period, Weighted Average Grant Date Fair Value | $8.20 | $3.57 | $8.20 | $3.57 |
Share-based Compensation Arrangement by Share-based Payment Award, Fair Value Assumptions and Methodology [Abstract] | ' | ' | ' | ' |
Expected volatility | 80.00% | 82.00% | 80.00% | 82.00% |
Expected term, in years | '5 years 11 months 4 days | '5 years 6 months | '5 years 11 months 4 days | '5 years 6 months |
Risk-free interest rate | 1.88% | 1.02% | 1.88% | 1.02% |
Expected dividend yield | 0.00% | 0.00% | 0.00% | 0.00% |
StockBased_Compensation_StockB
Stock-Based Compensation - Stock-Based Compensation Expense (Detail) (USD $) | 3 Months Ended | 6 Months Ended | ||
In Thousands, unless otherwise specified | Jun. 30, 2014 | Jun. 30, 2013 | Jun. 30, 2014 | Jun. 30, 2013 |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ' | ' | ' | ' |
Total | $1,630 | $1,060 | $3,417 | $2,153 |
Research and Development | ' | ' | ' | ' |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ' | ' | ' | ' |
Stock-based compensation expense | 901 | 566 | 1,911 | 1,147 |
Selling, General and Administrative Expenses | ' | ' | ' | ' |
Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Line Items] | ' | ' | ' | ' |
Stock-based compensation expense | $729 | $494 | $1,506 | $1,006 |
StockBased_Compensation_Summar
Stock-Based Compensation - Summary of Stock Option Activity and Related Information (Detail) (USD $) | 6 Months Ended |
In Thousands, except Share data, unless otherwise specified | Jun. 30, 2014 |
Options Outstanding | ' |
Beginning balance | 6,969,303 |
Granted | 166,750 |
Exercised | -134,924 |
Forfeited | -186,166 |
Ending balance | 6,814,963 |
Vested and expected to vest | 6,582,978 |
Exercisable | 4,496,727 |
Weighted-Average Exercise Price per Share | ' |
Beginning balance | $6.38 |
Granted | $11.73 |
Exercised | $5.80 |
Forfeited | $9.90 |
Ending balance | $6.42 |
Vested and expected to vest | $6.32 |
Exercisable | $4.94 |
Weighted- Average Remaining Contractual Life | ' |
Balance | '6 years 8 months 15 days |
Vested and expected to vest | '6 years 7 months 18 days |
Exercisable | '5 years 7 months 13 days |
Aggregate Intrinsic Value | ' |
Balance | $74,811 |
Vested and expected to vest | 72,938 |
Exercisable | $56,014 |