(1) | In accordance with Exchange Act Rule 0-11, the maximum number of securities of Sierra Oncology, Inc. (“Sierra Oncology”) to which this transaction applies is estimated, as of April 25, 2022, to be 37,864,342, which consists of (a) 24,419,349 shares of Sierra Oncology common stock outstanding as of April 25, 2022, entitled to receive consideration of $55.00 per share upon the effectiveness of the transaction; (b) 925,907 shares of Sierra Oncology common stock deemed to be issuable upon the cashless exercise of 925,925 Sierra Oncology pre-funded warrants outstanding as of April 25, 2022 entitled to receive the consideration of $55.00 per share in connection with the transaction; (c) 7,279,578 shares of Sierra Oncology common stock underlying Sierra Oncology Series A warrants outstanding as of April 25, 2022 entitled to receive $45.98 per underlying share in connection with the transaction, calculated in accordance with the terms of the Series A warrants; and (d) 5,239,490 shares of Sierra Oncology common stock underlying in-the-money Sierra Oncology stock options outstanding as of April 25, 2022 entitled to receive consideration of $55.00 per underlying share, minus any applicable exercise price, upon the effectiveness of the transaction. |