Exhibit 23.1
Consent of Independent Registered Public Accounting Firm
We consent to the reference to our firm under the caption “Experts” in this Registration Statement (FormS-3) and related Prospectus of bluebird bio, Inc. for the registration of common stock, preferred stock, warrants, units and debt securities and to the incorporation by reference therein of our reports dated February 22, 2017, with respect to the consolidated financial statements of bluebird bio, Inc., and the effectiveness of internal control over financial reporting of bluebird bio, Inc., included in its Annual Report (Form10-K) for the year ended December 31, 2016, filed with the Securities and Exchange Commission.
/s/ Ernst & Young LLP
Boston, Massachusetts
February 22, 2017