Exhibit 32.1
CERTIFICATION
I, Steven Nichtberger, MD, certify that:
| 1. | I have reviewed this Amendment No. 1 to Annual Report on Form 10-K/A of Tengion, Inc.; and |
| 2. | Based on my knowledge, this annual report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report. |
Date: April 18, 2011
| /s/ Steven Nichtberger | |
| Steven Nichtberger, MD | |
| President and Chief Executive Officer | |