Amphastar Pharmaceuticals (AMPH) 10-K 14 Mar 18 2017 FY Annual report Financial data

Document And Entity Information

Document And Entity Information - USD ($)	12 Months Ended
	Dec. 31, 2017	Mar. 06, 2018	Jun. 30, 2017
Document and Entity Information [Abstract]
Entity Registrant Name	Amphastar Pharmaceuticals, Inc.
Trading Symbol	amph
Document Type	10-K
Current Fiscal Year End Date	--12-31
Amendment Flag	false
Entity Central Index Key	1,297,184
Entity Current Reporting Status	Yes
Entity Voluntary Filers	No
Entity Filer Category	Accelerated Filer
Entity Well-known Seasoned Issuer	No
Document Period End Date	Dec. 31, 2017
Document Fiscal Year Focus	2,017
Document Fiscal Period Focus	FY
Entity Common Stock, Shares Outstanding		46,350,595
Entity Public Float			$ 638,082,059

CONDENSED CONSOLIDATED BALANCE

CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Current Assets:
Cash and cash equivalents	$ 65,594	$ 72,354
Short-term investments	2,635	527
Restricted cash and short-term investments	4,155	1,390
Accounts receivable, net	35,996	26,777
Inventories	63,609	79,754
Income tax refunds and deposits	6,036	22
Prepaid expenses and other assets	9,753	3,272
Total current assets	187,778	184,096
Property, plant, and equipment, net	185,339	152,944
Goodwill and intangible assets, net	45,140	50,307
Other assets	8,663	9,390
Deferred tax assets	27,745	31,001
Total assets	454,665	427,738
Current Liabilities:
Accounts payable and accrued liabilities	57,555	47,546
Income taxes payable	3,325	7,705
Current portion of long-term debt and capital leases	6,312	5,366
Total current liabilities	67,192	60,617
Long-term reserve for income tax liabilities	879	845
Long-term debt and capital leases, net of current portion	40,844	32,356
Deferred tax liabilities	1,361	1,455
Other long-term liabilities	7,060	3,210
Total liabilities	117,336	98,483
Stockholders’ equity:
Preferred stock: par value $0.0001; 20,000,000 shares authorized; no shares issued and outstanding
Common stock: par value $0.0001; 300,000,000 shares authorized; 50,039,212 and 46,623,581 shares issued and outstanding as of December 31, 2017 and 47,765,149 and 46,248,622 shares issued and outstanding as of December 31, 2016, respectively	5	5
Additional paid-in capital	313,891	283,123
Retained earnings	76,235	70,855
Accumulated other comprehensive loss	(2,100)	(4,696)
Treasury stock	(50,702)	(20,032)
Total stockholders’ equity	337,329	329,255
Total liabilities and stockholders’ equity	$ 454,665	$ 427,738

CONDENSED CONSOLIDATED BALANCE3

CONDENSED CONSOLIDATED BALANCE SHEETS (Parenthetical) - $ / shares	Dec. 31, 2017	Dec. 31, 2016
CONDENSED CONSOLIDATED BALANCE SHEETS
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares authorized	20,000,000	20,000,000
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Common stock; shares authorized	300,000,000	300,000,000
Common stock; shares issued	50,039,212	47,765,149
Common stock; shares outstanding	46,623,581	46,248,622

CONDENSED CONSOLIDATED STATEMEN

CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS - USD ($) shares in Thousands, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
Net revenues	$ 240,175	$ 255,165	$ 251,519
Cost of revenues	149,380	150,976	174,172
Gross profit	90,795	104,189	77,347
Operating (income) expenses:
Selling, distribution, and marketing	6,460	5,466	5,470
General and administrative	44,458	41,832	41,504
Research and development	43,415	41,199	37,271
Gain on sale of intangible assets	(2,643)
Total operating expenses	91,690	88,497	84,245
Income (loss) from operations	(895)	15,692	(6,898)
Non-operating income (expenses):
Interest income	425	270	315
Interest expense	(826)	(1,024)	(987)
Other income (expenses), net	2,919	8	(2,794)
Total non-operating income (expenses), net	2,518	(746)	(3,466)
Income (loss) before income taxes	1,623	14,946	(10,364)
Income tax expense (benefit)	(2,885)	4,414	(7,577)
Net income (loss)	$ 4,508	$ 10,532	$ (2,787)
Net income (loss) per share:
Basic (in Dollars per share)	$ 0.10	$ 0.23	$ (0.06)
Diluted (in Dollars per share)	$ 0.09	$ 0.22	$ (0.06)
Weighted-average shares used to compute net income (loss) per share:
Basic (in Shares)	46,107	45,375	44,961
Diluted (in Shares)	48,367	47,504	44,961

CONDENSED CONSOLIDATED STATEME5

CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
CONDENSED CONSOLIDATED STATEMENTS OF COMPREHENSIVE INCOME (LOSS)
Net income (loss)	$ 4,508	$ 10,532	$ (2,787)
Other comprehensive income (loss), net of income taxes
Foreign currency translation adjustment	2,713	(1,800)	(805)
Change in pension obligations	(117)	(421)	(16)
Total other comprehensive income (loss)	2,596	(2,221)	(821)
Total comprehensive income (loss)	$ 7,104	$ 8,311	$ (3,608)

CONSOLIDATED STATEMENTS OF STOC

CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY - USD ($) $ in Thousands	Common Stock	Additional Paid-in Capital [Member]	Retained Earnings [Member]	Accumulated Other Comprehensive Income (Loss) [Member]	Treasury Stock [Member]	Total
Balance at Dec. 31, 2014	$ 4	$ 220,745	$ 63,110	$ (1,654)	$ (345)	$ 281,860
Balance at Dec. 31, 2014	44,676,167				(29,400)
Changes in Stockholders' Equity
Net income (loss)			(2,787)			(2,787)
Accumulated other comprehensive loss				(821)		(821)
Treasury stock acquired					$ (9,865)	(9,865)
Treasury stock acquired (in Shares)					(735,679)
Issuance of treasury stock in connection with the Company's equity plans		(38)			$ 38
Issuance of treasury stock in connection with the Company's equity plans (in Shares)					3,364
Issuance of common stock in connection with the Company's equity plans	$ 1	14,200				14,201
Issuance of common stock in connection with the Company's equity plans (in Shares)	1,284,039
Share-based compensation expense		12,815				12,815
Tax effect of share-based compensation		107				107
Balance at Dec. 31, 2015	$ 5	247,829	60,323	(2,475)	$ (10,172)	295,510
Balance at Dec. 31, 2015	45,960,206				(761,715)
Changes in Stockholders' Equity
Net income (loss)			10,532			10,532
Accumulated other comprehensive loss				(2,221)		(2,221)
Treasury stock acquired					$ (9,908)	(9,908)
Treasury stock acquired (in Shares)					(759,067)
Issuance of treasury stock in connection with the Company's equity plans		(48)			$ 48
Issuance of treasury stock in connection with the Company's equity plans (in Shares)					4,255
Issuance of common stock in connection with the Company's equity plans		20,639				20,639
Issuance of common stock in connection with the Company's equity plans (in Shares)	1,804,943
Share-based compensation expense		15,124				15,124
Tax effect of share-based compensation		(421)				(421)
Balance at Dec. 31, 2016	$ 5	283,123	70,855	(4,696)	$ (20,032)	$ 329,255
Balance at Dec. 31, 2016	47,765,149				(1,516,527)	46,248,622
Changes in Stockholders' Equity
Net income (loss)			4,508			$ 4,508
Accumulated other comprehensive loss				2,596		2,596
Treasury stock acquired					$ (30,747)	(30,747)
Treasury stock acquired (in Shares)					(1,905,653)
Issuance of treasury stock in connection with the Company's equity plans		(77)			$ 77
Issuance of treasury stock in connection with the Company's equity plans (in Shares)					6,549
Issuance of common stock in connection with the Company's equity plans		13,758				13,758
Issuance of common stock in connection with the Company's equity plans (in Shares)	2,274,063
Share-based compensation expense		17,087				17,087
Beginning balance adjustment to retained earnings as a result of the adoption of ASU No. 2016-09			872			872
Balance at Dec. 31, 2017	$ 5	$ 313,891	$ 76,235	$ (2,100)	$ (50,702)	$ 337,329
Balance at Dec. 31, 2017	50,039,212				(3,415,631)	46,623,581

CONDENSED CONSOLIDATED STATEME7

CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Cash Flows From Operating Activities:
Net income (loss)	$ 4,508	$ 10,532	$ (2,787)
Reconciliation to net cash provided by operating activities:
Loss (gain) on disposal and impairment of long-lived assets	(2,337)	1,242	310
Depreciation of property, plant, and equipment	12,580	12,047	11,314
Amortization of product rights, trademarks, and patents	2,856	2,517	1,938
Share-based compensation	17,087	15,124	12,815
Reserve for uncertain tax positions	34	347	(1)
Changes in deferred taxes	3,899	(3,618)	(7,880)
Changes in operating assets and liabilities:
Accounts receivable, net	(8,102)	6,377	(11,012)
Inventories	18,650	(9,715)	9,775
Prepaid expenses and other assets	(4,817)	1,129	(699)
Income tax refund, deposits, and payable	(11,836)	3,329	(71)
Accounts payable and accrued liabilities	6,687	(751)	(3,021)
Net cash provided by operating activities	39,209	38,560	10,681
Cash Flows From Investing Activities:
Business Acquisitions		(12,461)
Purchases and construction of property, plant, and equipment	(35,099)	(21,382)	(15,996)
Sale of intangible assets	2,000
Purchase of short-term investments	(5,645)	(3,602)
Maturity of short-term investments	3,650	3,075
Changes in restricted short-term investments	(2,765)	(105)	210
Payment of deposits and other assets	(896)	(5,026)	(1,139)
Net cash used in investing activities	(38,755)	(39,501)	(16,925)
Cash Flows From Financing Activities:
Net proceeds from equity plans	13,758	21,502	14,308
Purchase of treasury stock	(30,747)	(9,908)	(9,865)
Proceeds from issuance of long-term debt	18,983	10,198	6,785
Principal payments on long-term debt	(9,712)	(14,652)	(8,991)
Net cash provided by (used in) financing activities	(7,718)	7,140	2,237
Effect of exchange rate changes on cash	504	81	2,253
Net increase (decrease) in cash and cash equivalents	(6,760)	6,280	(1,754)
Cash and cash equivalents at beginning of period	72,354	66,074	67,828
Cash and cash equivalents at end of period	65,594	72,354	66,074
Noncash Investing and Financing Activities:
Equipment acquired under capital leases		1,238	150
Supplemental Disclosures of Cash Flow Information:
Interest paid, net of capitalized interest	1,877	1,722	1,941
Income taxes paid	$ 4,876	$ 3,397	$ 146

General

General	12 Months Ended
	Dec. 31, 2017
General
General	Note 1. General Amphastar Pharmaceuticals, Inc., a California corporation, was incorporated on February 29, 1996 and merged with and into Amphastar Pharmaceuticals, Inc., a Delaware corporation, in July 2004 (together with its subsidiaries, hereinafter referred to as “the Company”). The Company is a specialty pharmaceutical company that primarily develops, manufactures, markets, and sells generic and proprietary injectable, inhalation, and intranasal products, including products with high technical barriers to market entry. Additionally, the Company sells insulin active pharmaceutical ingredient, or API, products. Most of the Company’s products are used in hospital or urgent care clinical settings and are primarily contracted and distributed through group purchasing organizations and drug wholesalers. The Company’s insulin API products are sold to other pharmaceutical companies for use in their own products and are being used by the Company in the development of injectable finished pharmaceutical products. The Company’s inhalation products will be primarily distributed through drug retailers if they are approved and brought to market.

Summary of Significant Accounti

Summary of Significant Accounting Policies	12 Months Ended
	Dec. 31, 2017
Summary of Significant Accounting Policies
Summary of Significant Accounting Policies	Note 2. Summary of Significant Accounting Policies Basis of Presentation The accompanying consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries, and are prepared in accordance with accounting principles generally accepted in the United States, or GAAP. Certain amounts in the prior years’ consolidated statements of operations and consolidated balance sheets have been reclassified to conform to the current year presentation. This reclassification has no impact on net income or cash flows. All significant intercompany activity has been eliminated in the preparation of the consolidated financial statements. Effective January 1, 2017, the Company prospectively adopted certain requirements of Accounting Standards Update, or ASU, No. 2016-09 to classify cash flows related to excess tax benefits in operating activities and directly record all excess tax benefits and tax deficiencies in income tax expense or benefit in the consolidated statement of operations without adjusting prior periods. The Company’s subsidiaries include: (1) International Medication Systems, Limited, or IMS, (2) Armstrong Pharmaceuticals, Inc., or Armstrong, (3) Amphastar Nanjing Pharmaceuticals Inc., or ANP, (4) Nanjing Letop Fine Chemistry Co., Ltd., or Letop, (5) Nanjing Hanxin Medical Technology Co., Ltd., or Hanxin, (6) Nanjing Baixin Trading Co., Ltd., or Baixin, (7) Amphastar France Pharmaceuticals, S.A.S., or AFP, (8) Amphastar UK Ltd., or AUK, and (9) International Medication Systems (UK) Limited, or IMS UK. Use of Estimates The preparation of consolidated financial statements in accordance with GAAP requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from those estimates. The principal accounting estimates include: determination of allowances for doubtful accounts and discounts, provision for chargebacks and rebates, provision for product returns, adjustment of inventory to their net realizable values, impairment of long-lived and intangible assets and goodwill, self-insured claims, workers’ compensation liabilities, litigation reserves, stock price volatilities for share-based compensation expense, valuation allowances for deferred tax assets, and liabilities for uncertain income tax positions. Foreign Currency The functional currency of the Company, its domestic subsidiaries, its Chinese subsidiary, ANP, and its U.K. subsidiary, AUK, is the U.S. dollar, or USD. ANP maintains its books of record in Chinese Yuan. These books are remeasured into the functional currency of USD using the current or historical exchange rates. The resulting currency remeasurement adjustments and other transactional foreign currency exchange gains and losses are reflected in the Company’s statements of operations. The Company’s French subsidiary, AFP, maintains its books of record in Euros. Its other Chinese subsidiaries, maintain their books of record in Chinese Yuan. Its U.K. subsidiary, IMS UK, maintains its books of record in Great Britain Pounds. These local currencies have been determined to be the subsidiaries’ respective functional currencies. These books of records are translated into USD using average exchange rates during the period. Assets and liabilities are translated at the rate of exchange prevailing on the balance sheet date. Equity is translated at the prevailing rate of exchange at the date of the equity transactions. Translation adjustments are reflected in stockholders’ equity and are included as a component of other accumulated comprehensive income (loss). The unrealized gains or losses of intercompany foreign currency transactions that are of a long-term investment nature are reported in other accumulated comprehensive income (loss). The unrealized gains and losses of intercompany foreign currency transactions that are of a long-term investment nature for the years ended December 31, 2017, 2016, and 2015 were a $4.3 million gain, $1.5 million loss, and a $2.0 million loss, respectively. Additionally, the Company does not undertake hedging transactions to cover its foreign currency exposure. Comprehensive Income (loss) For the years ended December 31, 2017, 2016 and 2015, the Company included its foreign currency translation gain or loss and change in pension obligation of its defined benefit pension plan as part of its comprehensive income (loss) . Income tax expense of $1.5 million was allocated to other comprehensive income for the year ended December 31, 2017. There was no material income tax expense (benefit) allocated to other comprehensive loss for the years ended December 31, 2016 and 2015. Shipping and Handling Costs For the years ended December 31, 2017, 2016, and 2015, the Company included shipping and handling costs of approximately $3.0 million, $2.4 million, and $2.6 million, respectively, in selling, distribution and marketing expenses in the accompanying consolidated statements of operations. Research and Development Costs Research and development costs are charged to expense as incurred and consist of costs incurred to further the Company’s research and development activities including salaries and related employee benefits, costs associated with clinical trials, nonclinical research and development activities, regulatory activities, research‑related overhead expenses and fees paid to external service providers. The Company may produce or purchase inventories prior to or with the expectation of receiving marketing authorization in the near term, based on operational decisions about the most effective use of existing resources. This inventory is referred to as pre‑launch inventory. It is the Company’s accounting policy that the pre-launch inventory is capitalized if it has a probable future economic benefit. If marketing authorization is received and previously expensed pre‑launch inventory is sold, such sales may contribute up to a 100% margin to the Company’s operating results. Pre‑launch inventory costs include cost of work in process, materials, and finished drug products. As of December 31, 2017, 2016, and 2015, the Company did not have material capitalized pre-launch inventory. Financial Instruments The carrying amounts of cash and cash equivalents, short-term investments, restricted cash and short-term investments, accounts receivable, accounts payable, accrued expenses, and short-term borrowings approximate fair value due to the short maturity of these items. The majority of the Company’s long-term obligations consist of variable rate debt, and their carrying value approximates fair value as the stated borrowing rates are comparable to rates currently offered to the Company for instruments with similar maturities. However, the Company has one fixed-rate, long-term mortgage for which the carrying value differs from the fair value and is not remeasured on a recurring basis (see Note 12). The Company at times enters into fixed interest rate swap contracts to exchange the variable interest rates for fixed interest rates without the exchange of the underlying notional debt amounts. Such interest rate swap contracts are recorded at their fair values. Cash and Cash Equivalents Cash and cash equivalents consist of cash, money market accounts, certificates of deposit and highly liquid investments purchased with original maturities of three months or less. Short-Term Investments Short-term investments as of December 31, 2017 consisted of certificates of deposit with original expiration dates within 12 months. Restricted Cash and Short-term Investments Restricted cash and short-term investments are collateral required for the Company to effect a standby letter of credit and to qualify for workers’ compensation self-insurance and are available to meet the Company’s workers’ compensation obligations on a current basis, as needed. As of December 31, 2017, restricted cash and short-term investments included $1.9 million in cash and $2.3 million in certificates of deposit. As of December 31, 2016, restricted cash and short-term investments include $1.4 million in certificates of deposit. The certificates of deposit have original maturities greater than three months and are classified as current assets. Allowance for Doubtful Accounts Receivable The Company evaluates the collectability of accounts receivable based on a combination of factors. When the Company is aware of circumstances that may impair a customer’s ability to pay subsequent to the original sale, the Company records a specific allowance to reduce the amounts receivable to the amount that the Company reasonably believes to be collectable. For all other customers, the Company recognizes an allowance for doubtful accounts based on factors that include the length of time the receivables are past due, industry and geographic concentrations, the current business environment and historical collection experience. As of December 31, 2017 and 2016, the Company's allowance for doubtful accounts was $0.3 million and $0.3 million, respectively. Inventories Inventories consist of currently marketed products and products manufactured under contract. Inventories are stated using the first-in, first-out method, on a consistent basis. In 2016, the Company prospectively adopted ASU No. 2015-11, Simplifying the Measurement Inventory, and states inventory at the lower of cost and net realizable value. Provisions are made for slow‑moving, unsellable, or obsolete items. Net realizable value is determined using the estimated selling price, in the ordinary course of business, less estimated costs to complete and dispose. Property, Plant and Equipment Property, plant and equipment are stated at cost or, in the case of assets acquired in a business combination, at fair value on the purchase date. Depreciation and amortization expense is computed using the straight‑line method over the estimated useful lives of the related assets as follows: Buildings 20 - 31 years Machinery and equipment 2 - 12 years Furniture and fixtures 3 - 7 years Automobiles 4 - 5 years Leasehold improvements Lesser of remaining lease term or useful life Intangible Assets Intangible assets with finite lives are amortized using the straight-line method over the period the asset is expected to contribute directly or indirectly to the future cash flows of the Company as follows: Product rights 5 - 15 years Patents 10 - 20 years Land-use rights 37 - 50 years Impairment of Long‑Lived Assets, including Identifiable Definite-Lived Intangible Assets The Company reviews long-term and identifiable definite-lived intangible assets or asset groups for impairment when events or changes in circumstances indicate that the carrying amount of an asset or asset group may not be recoverable. If the sum of the expected future undiscounted cash flows is less than the carrying amount of the asset or an asset group, further impairment analysis is performed. An impairment loss is measured as the amount by which the carrying amount of the asset or asset groups exceeds the fair value (assets to be held and used) or fair value less cost to sell (assets to be disposed of). The Company also reviews the useful lives of its assets periodically to determine whether events and circumstances warrant a revision to the remaining useful life. Changes in the useful life are adjusted prospectively by revising the remaining period over which the asset is amortized. Deferred Income Taxes The Company utilizes the liability method of accounting for income taxes, under which deferred taxes are determined based on the temporary differences between the financial statements and the tax basis of assets and liabilities using enacted tax rates. A valuation allowance is recorded when it is more likely than not that the deferred tax assets will not be realized. At December 31, 2017, the Company has not completed its accounting of certain areas for the tax effects of the enactment of the Tax Act. Impairment of Indefinite-Lived Intangible Asset and Goodwill The Company reviews indefinite‑lived intangible asset and goodwill for impairment in the fourth quarter of each year or more frequently if indicators of impairment are present. When the Company chooses to perform a qualitative assessment, it evaluates economic, industry and company-specific factors as an initial step. If the Company determines it is more likely than not that the indefinite-lived intangible asset is impaired or the fair value of a reporting unit is less than its carrying amount, further quantitative impairment process is then performed; otherwise, no further testing is required. An impairment loss is recorded if the asset’s fair value is less than its carrying value. The Company also periodically reviews the indefinite-lived intangible asset to determine if events and circumstances continue to support an indefinite useful life. If the life is no longer indefinite, the asset is tested for impairment. The carrying value, after recognition of any impairment loss, is amortized over its remaining useful life. Accounts payable and accrued liabilities Accounts payable and accrued liabilities consisted of the following: December 31, 2017 2016 (in thousands) Accrued customer fees and rebates $ 15,981 $ 6,940 Accrued payroll and related benefits 15,680 13,847 Accrued product returns, current portion 4,133 1,800 Other accrued liabilities 5,132 5,027 Total accrued liabilities 40,926 27,614 Accounts payable 16,629 19,932 Total Accounts payable and accrued liabilities $ 57,555 $ 47,546 Self-Insured Claims The Company is primarily self-insured, up to certain limits, for workers’ compensation claims. The Company has purchased stop-loss insurance, which will reimburse the Company for individual claims in excess of $350,000 annually or aggregate claims exceeding $2.6 million annually. Operations are charged with the cost of claims reported and an estimate of claims incurred but not reported. A liability for unpaid claims and the associated claim expenses, including incurred but not reported losses, is actuarially determined and reflected in accrued liabilities in the accompanying consolidated balance sheets. Total expense under the program was approximately $1.5 million, $1.6 million, and $1.2 million, for the years ended December 31, 2017, 2016 and 2015, respectively. The self-insured claims liability was $4.1 million and $3.5 million at December 31, 2017 and 2016, respectively. The determination of such claims and expenses and the appropriateness of the related liability is reviewed periodically and updated, as necessary. Changes in estimates are recorded in the period identified. Business Combinations If an acquired set of activities and assets is capable of being operated as a business consisting of inputs and processes from the viewpoint of a market participant, the asset acquired and liabilities assumed are a business. Business combinations are accounted for using the acquisition method of accounting, which requires an acquirer to recognize the assets acquired and the liabilities assumed at the acquisition date measured at their fair values as of that date. Fair value determinations are based on discounted cash flow analyses or other valuation techniques. In determining the fair value of the assets acquired and liabilities assumed in a material acquisition, the Company may utilize appraisals from third party valuation firms to determine fair values of some or all of the assets acquired and liabilities assumed, or may complete some or all of the valuations internally. In either case, the Company takes full responsibility for the determination of the fair value of the assets acquired and liabilities assumed. The value of goodwill reflects the excess of the fair value of the consideration conveyed to the seller over the fair value of the net assets received. Acquisition-related costs that the Company incurs to effect a business combination are expensed in the periods in which the costs are incurred. When the operations of the acquired businesses were not material to the Company’s consolidated financial statements, no pro forma presentations were disclosed. Recent Accounting Pronouncements In May 2014, the Financial Accounting Standards Board, or FASB, issued Accounting Standard Update, or ASU, No. 2014-09 Revenue from Contracts with Customers , which creates a single source of revenue guidance for companies in all industries. Subsequently, the FASB issued multiple updates. The new standard provides guidance for all revenue arising from contracts with customers and affects all entities that enter into contracts to provide goods or services to their customers, unless the contracts are within the scope of other accounting standards. It also provides a model for the measurement and recognition of gains and losses on the sale of certain nonfinancial assets. The guidance also requires expanded disclosures relating to the nature, amount, timing, and uncertainty of revenue and cash flows arising from contracts with customers. Additionally, qualitative and quantitative disclosures are required regarding customer contracts, significant judgments and changes in judgments, and assets recognized from the costs to obtain or fulfill a contract. This guidance permits two methods of adoption: retrospectively to each prior reporting period presented (full retrospective method), or retrospectively with the cumulative effect of initially applying the guidance recognized at the date of initial application (the cumulative catch-up transition method). Based on ASU No. 2015-14 Deferral of the Effective Date , issued in August 2015, this guidance will be effective for the Company beginning in the first quarter of 2018, including interim periods within the year. The Company will adopt the standard in 2018 using the modified retrospective transition method. The Company’s revenue are generated from the sale of pharmaceutical products to various customers, and the adoption of the new standard will not have a material impact on these transactions or on the consolidated financial statements and related disclosures. In February 2016, the FASB issued ASU No. 2016-02 Leases , that is aimed at making leasing activities more transparent and comparable, and which requires substantially all leases be recognized by lessees on their balance sheets as a right-of-use asset and corresponding lease liability, including leases currently accounted for as operating leases. This guidance will become effective for the Company’s interim and annual reporting periods during the year ending December 31, 2019, and all annual and interim reporting periods thereafter. Early adoption is permitted. The Company is required to use a modified retrospective approach for leases that exist or are entered into after the beginning of the earliest comparative period in the financial statements for the reporting periods in which the guidance is adopted. While the Company continues to evaluate the provisions of ASC 842 to determine how it will be affected, the primary effect of adopting the new standard will be to record assets and obligations for current operating leases on its consolidated financial statements. Footnote 16 provides details on the Company’s current operating lease arrangements. The adoption of ASC 842 is not expected to have a material impact on the Company’s results of operations or cash flows. In June 2016, the FASB issued ASU No. 2016-13 Financial Instruments – Credit Losses , which is aimed at providing financial statement users with more useful information about the expected credit losses on financial instruments and other commitments to extend credit. The standard update changes the impairment model for financial assets measured at amortized cost, requiring presentation at the net amount expected to be collected. The measurement of expected credit losses requires consideration of a broader range of reasonable and supportable information to inform credit loss estimates. Available-for-sale debt securities with unrealized losses will be recorded through an allowance for credit losses. The guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2020. Early adoption is permitted for interim or annual periods after December 31, 2019. The Company will be required to apply the standard’s provisions as a cumulative-effect adjustment to retained earnings as of the beginning of the first reporting period in which the guidance is effective. The Company does not believe that the adoption of this accounting guidance will have a material impact on its consolidated financial statements and related disclosures. In August 2016, the FASB issued ASU No. 2016-15 Classification of Certain Cash Receipts and Cash Payments , which is aimed at addressing certain issues regarding classifications of certain cash receipts and cash payments on the statement of cash flows where diversity in practice was identified. The guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2018. Early adoption is permitted. The Company will be required to apply the guidance retrospectively in the first interim and each annual period in which the guidance is adopted. The Company does not believe that the adoption of this accounting guidance will have a material impact on the Company’s consolidated financial statements and related disclosures. In October 2016, the FASB issued ASU No. 2016-16 Intra-Entity Transfers of Assets Other Than Inventory , which requires an entity to recognize the income tax consequences of intra-entity transfer of an asset other than inventory when the transfer occurs. The guidance is effective for the Company's interim and annual reporting periods during the year ending December 31, 2018. Early adoption is permitted as of the beginning of an annual reporting period for which financial statements, interim or annual, have not been issued. The amendments will be applied on a modified retrospective basis through a cumulative-effect adjustment directly to retained earnings as of the beginning of the period of adoption. The Company is currently evaluating the impact that the adoption of this guidance will have on its consolidated financial statements and related disclosures. In November 2016, the FASB issued ASU No. 2016-18 Statement of Cash Flows: Restricted Cash , which requires entities to show the changes in the total of cash, cash equivalents, restricted cash and restricted cash equivalents in the statement of cash flows. As a result, the Company will no longer present transfers between cash and cash equivalents and restricted cash and restricted cash equivalents in the statement of cash flows. The guidance is effective for the Company's interim and annual reporting periods during the year ending December 31, 2018. Early adoption is permitted, including adoption in an interim period. The amendments will be applied using a retrospective transition method to each period presented. The Company will be required to apply the guidance retrospectively when adopted. The Company will adopt this accounting guidance at the beginning of 2018. In January 2017, the FASB issued ASU No. 2017-01 Clarifying the Definition of a Business , which provides guidance to assist entities with evaluating when a set of transferred assets and activities is a business. Under the updated guidance, a set is not a business if substantially all of the fair value of the gross assets acquired is concentrated in a single identifiable asset or a group of similar assets. If the threshold is not met, the update requires that, to be a business, the set must include, at a minimum, an input and a substantive process that together significantly contribute to the ability to create outputs. The definition of outputs was also aligned with Accounting Standard Codification, or ASC 606 by focusing on revenue-generating activities. The guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2018, and prospectively applicable to any transactions occurring within the period of adoption. Early adoption is permitted. The Company is currently evaluating the impact that the adoption of this guidance will have on its consolidated financial statements and related disclosures. In January 2017, the FASB issued ASU No. 2017-04 simplifying the Test for Goodwill Impairment , which eliminates the requirement to calculate the implied fair value of goodwill. An entity should perform its annual, or interim, goodwill impairment test by comparing the fair value of a reporting unit with its carrying amount. An entity should recognize an impairment charge for the amount by which the carrying amount exceeds the reporting unit’s fair value; however, the loss recognized should not exceed the total amount of goodwill allocated to that reporting unit. The update also eliminated the requirements for any reporting unit with a zero or negative carrying amount to perform a qualitative assessment and, if it fails that qualitative test, to perform Step 2 of the goodwill impairment test. An entity is required to disclose the amount of goodwill allocated to each reporting unit with a zero or negative carrying amount of net assets. The guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2020, and applied on a prospective basis. Early adoption is permitted for interim and annual goodwill impairment testing dates after January 1, 2017. The Company currently does not believe that the adoption of this accounting guidance will have a material impact on its consolidated financial statements and related disclosures. In May 2017, the FASB issued ASU No. 2017-09 Scope of Modification Accounting , that clarifies when changes to the terms or conditions of a share-based payment award must be accounted for as modifications. The new guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2018, and applied prospectively to awards modified on or after the adoption date. Early adoption is permitted. The Company does not believe that the adoption of this accounting guidance will have a material impact on its consolidated financial statements and related disclosures. In August 2017, the FASB issued ASU No. 2017-12 Targeted Improvements to Accounting for Hedging Activities , which amends the hedge accounting model in ASC 815 to enable entities to better portray the economics of their risk management activities in the financial statements and enhance the transparency and understandability of hedge results. The amendments also simplify the application of hedge accounting in certain situations. The new guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2019. Early adoption is permitted. The Company does not believe that the adoption of this accounting guidance will have a material impact on its consolidated financial statements and related disclosures. In February 2018, the FASB issued ASU No. 2018-02 Reclassification of Certain Tax Effects from Accumulated Other Comprehensive Income , which allows entities to reclassify from accumulated other comprehensive income to retained earnings stranded tax effects resulting from the Tax Cuts and Jobs Act of 2017. The guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2019. Early adoption is permitted. The Company does not believe that the adoption of this accounting guidance will have a material impact on its consolidated financial statements and related disclosures.

Business Acquisitions

Business Acquisitions	12 Months Ended
	Dec. 31, 2017
Business Acquisitions
Business Acquisitions	Note 3. Business Acquisitions Acquisition of International Medication Systems (UK) Limited from UCB PHARMA GmbH In August 2016, the Company’s UK subsidiary, AUK, acquired IMS UK, a UK-based subsidiary of UCB PHARMA GmbH, including its trademarks, assets related to the products, as well as marketing authorizations for 33 products in the UK, Ireland, Australia, and New Zealand, representing 11 different injectable chemical entities. The Company paid $7.7 million in cash as consideration for the transaction. The Company is in the process of transferring the manufacturing of the purchased products to its facilities in California. The transfer will require approval of the UK Medicines and Healthcare products Regulatory Agency and other related regulatory agencies before the products can be sold by the Company. The transaction is accounted for as a business combination in accordance with ASC 805. The fair values of the assets acquired and liabilities assumed include marketing authorizations of $9.2 million, manufacturing equipment of $0.1 million, and deferred tax liability of $1.6 million. The acquired marketing authorizations intangible assets are subject to a straight-line amortization over a useful life of approximately 10 years. Acquisition of fourteen injectable products from Hikma Pharmaceuticals PLC In March 2016, the Company acquired 14 abbreviated new drug application, or ANDAs, representing 11 different injectable chemical entities from Hikma Pharmaceuticals PLC, or Hikma, for $4.0 million. This transaction was accounted for as a business combination in accordance with ASC 805. The ANDAs were estimated to have a fair value of $4.0 million, and were subject to a straight-line amortization over a useful life of approximately 15 years. In February 2017, the Company sold these products to an unrelated party. (See note 9) Acquisition of Nanjing Letop Medical Technology Co. Ltd. In January 2016, the Company’s Chinese subsidiary, ANP, acquired Nanjing Letop Medical Technology Co. Ltd. for $1.7 million consisting of $0.8 million in cash and a deposit of $0.9 million that ANP had previously paid to Letop and which was effectively eliminated upon the consummation of the transaction. The Company accounted for this transaction as a business combination in accordance with ASC 805. The Company recognized $1.4 million of acquired assets, $0.1 million of assumed liabilities, and $0.4 million of goodwill. Letop had previously supplied ANP with intermediates used in making various active pharmaceutical ingredients. In March 2016, the acquired subsidiary was renamed Nanjing Letop Fine Chemistry Co., Ltd.

Revenue Recognition

Revenue Recognition	12 Months Ended
	Dec. 31, 2017
Revenue Recognition
Revenue Recognition	Note 4. Revenue Recognition Generally, revenue is recognized at the time of product delivery to the Company’s customers. In some cases, revenue is recognized at the time of shipment when stipulated by the terms of the sale agreements. Revenues derived from contract manufacturing services are recognized when third-party products are shipped to customers, after the customer has accepted test samples of the products to be shipped. On June 30, 2016, the Company and Actavis Inc., or Actavis, amended the distribution agreement, which terminated the agreement in December 2016. Profit-sharing revenue under this agreement was recognized at the time Actavis sold the products to its customers. The Company does not recognize product revenue unless the following fundamental criteria are met: (i) persuasive evidence of an arrangement exists, (ii) transfer of title has occurred, (iii) the price to the customer is fixed or determinable, and (iv) collection is reasonably assured. Furthermore, the Company does not recognize revenue until all customer acceptance requirements have been met. The Company estimates and records reductions to revenue for discounts, product returns, and pricing adjustments, such as wholesaler chargebacks, in the same period that the related revenue is recorded. The Company’s accounting policy is to review each agreement involving contract development and manufacturing services to determine if there are multiple revenue-generating activities that constitute more than one unit of accounting. Revenues are recognized for each unit of accounting based on revenue recognition criteria relevant to that unit. The Company does not have any revenue arrangements with multiple deliverables. Provision for Chargebacks and Rebates The provision for chargebacks and rebates is a significant estimate used in the recognition of revenue. Wholesaler chargebacks relate to sales terms under which the Company agrees to reimburse wholesalers for differences between the gross sales prices at which the Company sells its products to wholesalers and the actual prices of such products that wholesalers resell them under the Company’s various contractual arrangements with third parties such as hospitals and group purchasing organizations in the United States. Rebates include primarily amounts paid to retailers, payers, and providers in the United States, including those paid to state Medicaid programs, and are based on contractual arrangements or statutory requirements. The Company estimates chargebacks and rebates at the time of sale to wholesalers based on wholesaler inventory stocking levels, historic chargeback and rebate rates, and current contract pricing. The provision for chargebacks and rebates is reflected in net revenues. The following table is an analysis of the chargeback and rebate provision: Year Ended December 31, 2017 2016 (in thousands) Beginning balance $ 39,709 $ 15,888 Provision for chargebacks and rebates 152,011 171,159 Credits and payments issued to third parties (173,250) (147,338) Ending balance $ 18,470 $ 39,709 Changes in the chargeback provision from period to period are primarily dependent on the Company’s sales to its wholesalers, the level of inventory held by wholesalers, and the wholesaler’s customer mix. Changes in the rebate provision from period to period are primarily dependent on retailer’s and other indirect customers’ purchases. The approach that the Company uses to estimate chargebacks has been consistently applied for all periods presented. Variations in estimates have been historically small. The Company continually monitors the provision for chargebacks and rebates and make adjustments when it believes that the actual chargebacks and rebates may differ from the estimates. The settlement of chargebacks and rebates generally occurs within 30 days to 60 days after the sale to wholesalers. Accounts receivable and/or accounts payable and accrued liabilities are reduced and/or increased by the chargebacks and rebate amounts depending on whether the Company has the right to offset with the customer. Of the provision for chargebacks and rebates as of December 31, 2017 and 2016, $6.8 million and 37.8 million were included in accounts receivable, net, on the consolidated balance sheets, respectively. The remaining provision of $11.7 million and $1.9 million were included in accounts payable and accrued liabilities, respectively. Accrual for Product Returns The Company offers most customers the right to return qualified excess or expired inventory for partial credit; however, API product sales are generally non-returnable. The Company’s product returns primarily consist of the returns of expired products from sales made in prior periods. Returned products cannot be resold. At the time product revenue is recognized, the Company records an accrual for estimated returns. The accrual is based, in part, upon the historical relationship of product returns to sales and customer contract terms. The Company also assesses other factors that could affect product returns including market conditions, product obsolescence, and the introduction of new competition. Although these factors do not normally give the Company’s customers the right to return products outside of the regular return policy, the Company realizes that such factors could ultimately lead to increased returns. The Company analyzes these situations on a case-by-case basis and makes adjustments to the product return reserve as appropriate. If the available information is not sufficient to estimate a reasonable product return accrual, revenues from the sales of the new product would not be recognized until the product is consumed by the end customer or rights of return granted under the return policy have expired. As of December 31, 2017 and 2016, cumulative sales of approximately $1.2 million and $0.5 million, respectively, for one of the Company’s products were not recognized in revenues, due to insufficient information available to estimate a reasonable product return accrual. The provision for product returns is reflected in net revenues. The following table is an analysis of product return liability: Year Ended December 31, 2017 2016 (in thousands) Beginning balance $ 3,143 $ 2,621 Provision for product returns 5,754 1,753 Credits issued to third parties (2,375) (1,231) Ending balance $ 6,522 $ 3,143 Of the provision of product returns as of December 31, 2017 and 2016, $4.1 million and $1.8 million were included in accounts payable and accrued liabilities on the consolidated balance sheets, respectively. For the years ended December 31, 2017 and 2016 , the Company’s aggregate product return rate was 1 .3% and 1.1% of qualified sales, respectively. The remaining provision of $2.4 million and $1.3 million were included in other long-term liabilities, respectively.

Income (Loss) per Share

Income (Loss) per Share	12 Months Ended
	Dec. 31, 2017
Income (Loss) per Share
Income (Loss) per Share	Note 5. Income (Loss) per Share Basic income (loss) per share is calculated based upon the weighted-average number of shares outstanding during the period. Diluted income per share gives effect to all potential dilutive shares outstanding during the period, such as stock options, nonvested restricted stock units, and shares issuable under the Company’s Employee Stock Purchase Plan, or ESPP. For the year ended December 31, 2017, options to purchase 839,651 shares of stock with a weighted-average exercise price of $26.43 per share, were excluded in the computation of diluted net income per share because the effect from the assumed exercise of these options would be anti-dilutive. For the year ended December 31, 2016, options to purchase 2,379,984 shares of stock with a weighted-average exercise price of $22.46 per share, were excluded in the computation of diluted net income per share because the effect from the assumed exercise of these options would be anti-dilutive. As the Company reported a net loss for the year ended December 31, 2015, the diluted net loss per share, as reported, equals the basic net loss per share since the effect of the assumed exercise of stock options, vesting of nonvested RSUs, and issuance of common shares under the Company’s ESPP are anti-dilutive. Total stock options, nonvested RSUs, and shares issuable under the Company’s ESPP excluded from the year ended December 31, 2015 net loss per share were 12,240,467 stock options; 866,540 nonvested RSUs, and 61,766 shares issuable under the ESPP. The following table provides the calculation of basic and diluted net income (loss) per share for each of the periods presented: Year Ended December 31, 2017 2016 2015 (in thousands, except per share data) Basic and dilutive numerator: Net income (loss) $ 4,508 $ 10,532 $ (2,787) Denominator: Weighted-average shares outstanding — basic 46,107 45,375 44,961 Net effect of dilutive securities: Incremental shares from equity awards 2,260 2,129 — Weighted-average shares outstanding — diluted 48,367 47,504 44,961 Net income (loss) per share — basic $ 0.10 $ 0.23 $ (0.06) Net income (loss) per share — diluted $ 0.09 $ 0.22 $ (0.06)

Segment Reporting

Segment Reporting	12 Months Ended
	Dec. 31, 2017
Segment Reporting
Segment Reporting	Note 6. Segment Reporting The Company has established two reporting segments that each report to the Chief Operating Decision Maker, or CODM, as defined in ASC 280, Segment Reporting. The Company’s performance is assessed and resources are allocated by the CODM based on the following two reportable segments: · Finished pharmaceutical products · Active pharmaceutical ingredients, or API The finished pharmaceutical products segment manufactures, markets and distributes enoxaparin, naloxone, lidocaine, as well as various other critical and non-critical care drugs. The API segment manufactures and distributes recombinant human insulin API and porcine insulin API for external customers and internal product development. Selected financial information by reporting segment is presented below: Year Ended December 31, 2017 2016 2015 (in thousands) Net revenues: Finished pharmaceutical products $ 230,139 $ 240,221 $ 224,941 API 10,036 14,944 26,578 Total net revenues 240,175 255,165 251,519 Gross profit: Finished pharmaceutical products 96,803 106,100 74,146 API (6,008) (1,911) 3,201 Total gross profit 90,795 104,189 77,347 Operating expenses 91,690 88,497 84,245 Income (loss) from operations (895) 15,692 (6,898) Non-operating income (expenses) 2,518 (746) (3,466) Income (loss) before income taxes $ 1,623 $ 14,946 $ (10,364) The Company manages its business segments to the gross profit level and manages its operating and other costs on a company-wide basis. The Company does not identify total assets by segment for internal purposes, as the Company’s CODM does not assess performance, make strategic decisions, or allocate resources based on assets. The amount of net revenues in the finished pharmaceutical product segment is presented below: Year Ended December 31, 2017 2016 2015 (in thousands) Finished pharmaceutical products net revenues: Naloxone $ 42,342 $ 47,532 $ 38,602 Phytonadione 37,946 33,315 19,804 Lidocaine 37,602 36,600 30,260 Enoxaparin 36,593 59,320 84,502 Epinephrine 25,914 25,661 14,936 Other finished pharmaceutical products 49,742 37,793 36,837 Total finished pharmaceutical products net revenues $ 230,139 $ 240,221 $ 224,941 Discontinuation of epinephrine injection, USP vial product In February 2017, the U.S. Food and Drug Administration, or FDA, requested the Company to discontinue the manufacturing and distribution of its epinephrine injection, USP vial product, which had been marketed under the “grandfather” exception to the FDA’s “Prescription Drug Wrap-Up” program. The Company discontinued selling this product in the second quarter of 2017. For the years ended December 31, 2017, 2016, and 2015, the Company recognized $17.8 million, $18.6 million, and $7.8 million in net revenues for the sale of this product, respectively. A charge of $3.3 million was included in the cost of revenues in its consolidated statements of operations for the year ended December 31, 2016 to adjust the related inventory and firm purchase commitments to their net realizable value due to the anticipated discontinuation of the product. Net revenues and carrying values of long-lived assets of enterprises by geographic regions are as follows: Net Revenue Long-Lived Assets Year Ended December 31, December 31, 2017 2016 2015 2017 2016 (in thousands) United States $ 234,321 $ 249,007 $ 243,295 $ 110,235 $ 104,110 China — — — 41,078 35,085 France 5,854 6,158 8,224 34,026 13,659 United Kingdom — — — — 90 Total $ 240,175 $ 255,165 $ 251,519 $ 185,339 $ 152,944

Customer and Supplier Concentra

Customer and Supplier Concentration	12 Months Ended
	Dec. 31, 2017
Customer and Supplier Concentration
Customer and Supplier Concentration	Note 7. Customer and Supplier Concentration Customer Concentrations Three large wholesale drug distributors, AmerisourceBergen Corporation, or AmerisourceBergen, Cardinal Health, Inc., or Cardinal, and McKesson Corporation, or McKesson, are all distributors of the Company’s products, as well as suppliers of a broad range of health care products. Actavis had exclusive marketing rights of the Company’s enoxaparin product to the U.S. retail pharmacy market until December 2016. The Company considers these four customers to be its major customers, as each individually and these customers collectively, represented a significant percentage of the Company’s net revenue for the years ended December 31, 2017, 2016, and 2015, and accounts receivable as of December 31, 2017 and 2016, respectively. The following table provides accounts receivable and net revenue information for these major customers: % of Total Accounts % of Net Receivable Revenue December 31, December 31, Year Ended December 31, 2017 2016 2017 2016 2015 Actavis (1) — 1 % — 14 % 21 % AmerisourceBergen 33 % 30 % 28 % 21 % 17 % Cardinal Health 12 % 28 % 23 % 22 % 17 % McKesson 22 % 19 % 27 % 21 % 22 % (1) The agreement with Actavis was terminated in December 2016. Supplier Concentrations The Company depends on suppliers for raw materials, active pharmaceutical ingredients, and other components that are subject to stringent FDA, requirements. Some of these materials may only be available from one or a limited number of sources. Establishing additional or replacement suppliers for these materials may take a substantial period of time, as suppliers must be approved by the FDA. Furthermore, a significant portion of raw materials may only be available from foreign sources. If the Company is unable to secure, on a timely basis, sufficient quantities of the materials it depends on to manufacture and market its products, it could have a materially adverse effect on the Company’s business, financial condition, and results of operations.

Fair Value Measurements

Fair Value Measurements	12 Months Ended
	Dec. 31, 2017
Fair Value Measurements
Fair Value Measurements	Note 8. Fair Value Measurements The accounting standards of the FASB, define fair value as the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants in the principal or most advantageous market for the asset or liability at the measurement date (an exit price). These standards also establish a hierarchy that prioritizes observable and unobservable inputs used in measuring fair value of an asset or liability, as described below: · Level 1 – Inputs to measure fair value are based on quoted prices (unadjusted) in active markets on identical assets or liabilities; · Level 2 – Inputs to measure fair value are based on the following: a) quoted prices in active markets on similar assets or liabilities, b) quoted prices for identical or similar instruments in inactive markets, or c) observable (other than quoted prices) or collaborated observable market data used in a pricing model from which the fair value is derived; and · Level 3 – Inputs to measure fair value are unobservable and the assets or liabilities have little, if any, market activity; these inputs reflect the Company’s own assumptions about the assumptions that market participants would use in pricing the assets or liabilities based on best information available in the circumstances. The fair value of the Company’s cash equivalents, short-term investments, and restricted cash and short-term investments approximates their respective carrying amounts. As of December 31, 2017, cash equivalents include money market accounts. Short-term investments consist of certificates of deposit with original expiration dates within 12 months. These certificates of deposit are carried at amortized cost in the Company’s consolidated balance sheet, which approximates their fair value determined based on Level 2 inputs. The restrictions on restricted cash and short-term investments have a negligible effect on the fair value of these financial assets. The Company does not hold any Level 3 instruments that are measured for fair value on a recurring basis. Nonfinancial assets and liabilities are not measured at fair value on a recurring basis but are subject to fair value adjustments in certain circumstances. These items primarily include long-lived assets, goodwill, and intangible assets for which the fair value of assets is determined as part of the related impairment test. As of December 31, 2017 and 2016, there were no significant adjustments to fair value for nonfinancial assets or liabilities.

Goodwill and Intangible Assets

Goodwill and Intangible Assets	12 Months Ended
	Dec. 31, 2017
Goodwill and Intangible Assets
Goodwill and Intangible Assets	Note 9. Goodwill and Intangible Assets The table below shows the weighted-average life, original cost, accumulated amortization, and net book value by major intangible asset classification: Weighted-Average Accumulated Life (Years) Original Cost Amortization Net Book Value (in thousands) Definite-lived intangible assets Cortrosyn® product rights 12 $ 27,134 $ 26,243 $ 891 IMS (UK) international product rights (1) 10 9,440 1,337 8,103 Patents 12 486 170 316 Land-use rights 39 2,540 419 2,121 Other intangible assets 4 69 46 23 Subtotal 12 39,669 28,215 11,454 Indefinite-lived intangible assets Trademark * 29,225 — 29,225 Goodwill - Finished pharmaceutical products * 4,461 — 4,461 Subtotal * 33,686 — 33,686 As of December 31, 2017 * $ 73,355 $ 28,215 $ 45,140 Weighted-Average Accumulated Life (Years) Original Cost Amortization Net Book Value (in thousands) Definite-lived intangible assets Cortrosyn® product rights 12 $ 27,134 $ 24,461 $ 2,673 IMS (UK) international product rights (1) 10 8,632 359 8,273 Acquired ANDAs (2) 15 4,000 222 3,778 Patents 10 293 137 156 Land-use rights 39 2,540 354 2,186 Other intangible assets 1 574 534 40 Subtotal 12 43,173 26,067 17,106 Indefinite-lived intangible assets Trademark * 29,225 — 29,225 Goodwill - Finished pharmaceutical products * 3,976 — 3,976 Subtotal * 33,201 — 33,201 As of December 31, 2016 * $ 76,374 $ 26,067 $ 50,307 * Intangible assets with indefinite lives have an indeterminable average life. (1) In August 2016, the Company acquired International Medication Systems (UK) Limited from UCB PHARMA GmbH for $7.7 million. The fair value of the marketing authorization was $9.2 million as of the acquisition date (see Note 3). (2) In February 2017, the Company sold the 14 ANDAs it had acquired from Hikma to an unrelated party for $6.4 million. Sale of Fourteen Injectable ANDAs In February 2017, the Company sold the 14 ANDAs it acquired in March 2016 from Hikma to an unrelated party. The consideration included a purchase price of $6.4 million of which the amount of $1.0 million was received upon closing, $1.0 million was received in the second quarter of 2017 and the remaining $4.4 million was received in January 2018. In addition to the purchase price, the purchaser agreed to pay the Company a royalty fee equal to 2% of net sales derived from purchaser’s sales of the products for the period from February 2017 through February 2027. The Company has not recognized any royalty fee revenue. The Company is also subject to a certain indemnification liability payable to the purchaser, which is limited up to $0.6 million. The Company recognized a gain of $2.6 million within operating (income) expenses on its consolidated statement of operations for the year ended December 31, 2017, and a receivable of $4.4 million in current other assets on its consolidated balance sheet as of December 31, 2017. Goodwill The changes in the carrying amounts of goodwill were as follows: December 31, 2017 2016 (in thousands) Beginning balance $ 3,976 $ 3,726 Goodwill related to acquisition of business — 391 Currency translation and other adjustments 485 (141) Ending balance $ 4,461 $ 3,976 Primatene ® Trademark In January 2009, the Company acquired the exclusive rights to the trademark, domain name, website and domestic marketing, distribution and selling rights related to Primatene ® Mist, an over-the-counter bronchodilator product, which are recorded at the allocated fair value of $29.2 million, which is its carrying value as of December 31, 2017. The trademark was determined to have an indefinite life. In determining its indefinite life, the Company considered the following: the expected use of the intangible; the longevity of the brand; the legal, regulatory and contractual provisions that affect their maximum useful life; the Company’s ability to renew or extend the asset’s legal or contractual life without substantial costs; effects of the regulatory environment; expected changes in distribution channels; maintenance expenditures required to obtain the expected future cash flows from the asset; and considerations for obsolescence, demand, competition and other economic factors. As a result of environmental concerns about Chlorofluorocarbons, or CFCs, the FDA issued a final ruling on January 16, 2009 that required the CFC formulation of its Primatene ® Mist product to be phased out by December 31, 2011. The former formulation of Primatene ® Mist contained CFCs as a propellant; however, the Company intends to use the trademark for a future version of Primatene ® that utilizes hydrofluoroalkane, or HFA, as a propellant. In 2013, the Company filed a new drug application, or NDA, for Primatene ® Mist and received a Prescription Drug User Fee Act date set for May 2014. In May 2014, the Company received a complete response letter, or CRL, from the FDA, which required additional non-clinical information, label revisions and follow-up studies (label comprehension, behavioral/human factors and actual use) to assess consumers’ ability to use the device correctly to support approval of the product in the over-the-counter setting. The Company submitted a responsive NDA amendment in June 2016 and received a second CRL from the FDA in December 2016, which requires additional packaging and label revisions and follow-up studies to assess consumers’ ability to use the product correctly to support approval in the over-the-counter setting . After several meetings with the FDA in 2017, the Company further revised its packaging and label and plans to perform another human factors study based on such revisions. In November 2017, the Company submitted its proposed protocol to the FDA. In March 2018, the Company received as Advice Letter from the FDA regarding our Proposed protocol. Based on that feedback the Company plans to conduct an additional human factors study. Once the Company receives acceptable results from the study, the Company will resubmit the NDA. The Company intends to continue to work with the FDA to address their concerns in the CRL and bring Primatene ® Mist back to the over-the-counter market. However, there can be no guarantee that any future amendment to the Company’s NDA will result in timely approval of Primatene ® Mist or approval at all. Based on the Company’s filed version of Primatene ® Mist, the long history of the Primatene ® trademark (marketed since 1963), and the Company’s perpetual rights to the trademark, the nature of the CRL received in December 2016, the plan that the HFA version will be marketed under the same trademark if approved by the FDA, and other factors previously considered, the trademark continues to have an indefinite useful life, and an impairment charge is not required based on the Company’s qualitative assessment as of December 31, 2017. Amortization Included in cost of revenues for the years ended December 31, 2017, 2016 and 2015 is product rights amortization expense of $2.7 million, $2.4 million, and $1.8 million, respectively, primarily related to Cortrosyn ® . As of December 31, 2017, the expected amortization expense for all amortizable intangible assets during the next five fiscal years ended December 31 and thereafter is as follows: (in thousands) 2018 $ 1,772 2019 870 2020 864 2021 864 2022 844 Thereafter 6,240 Total amortizable intangible assets 11,454 Indefinite-lived intangibles 33,686 Total intangibles (net of accumulated amortization) $ 45,140

Inventories

Inventories	12 Months Ended
	Dec. 31, 2017
Inventories
Inventories	Note 10. Inventories Inventories consist of the following: December 31, 2017 2016 (in thousands) Raw materials and supplies $ 19,973 $ 36,209 Work in process 22,469 22,266 Finished goods 21,167 21,279 Total inventories $ 63,609 $ 79,754 Charges of $8.5 million and $7.3 million were included in the cost of revenues in the Company’s consolidated statements of operations for the years ended December 31, 2017 and 2016, respectively, to adjust the Company’s inventory to their net realizable value. For the year ended December 31, 2017, the charge included $5.5 million related to enoxaparin inventory due to a decrease in the forecasted average selling price. For the year ended December 31, 2016, the charge included $3.1 million related to enoxaparin inventory due to a decrease in the forecasted average selling price and $3.3 million related to Epinephrine Injection, USP vial inventory items due to the anticipated discontinuation of the product.

Property, Plant, and Equipment

Property, Plant, and Equipment	12 Months Ended
	Dec. 31, 2017
Property, Plant, and Equipment
Property, Plant, and Equipment	Note 11. Property, Plant, and Equipment Property, plant, and equipment consist of the following: December 31, 2017 2016 (in thousands) Buildings $ 89,124 $ 85,283 Leasehold improvements 29,847 24,619 Land 7,110 6,857 Machinery and equipment 118,056 111,041 Furniture, fixtures, and automobiles 16,385 15,113 Construction in progress 58,145 32,044 Total property, plant, and equipment 318,667 274,957 Less accumulated depreciation (133,328) (122,013) Total property, plant, and equipment, net $ 185,339 $ 152,944 The Company incurred depreciation expense of $12.6 million, $12.0 million, and $11.3 million for the years ended December 31, 2017, 2016, and 2015, respectively. Interest expense capitalized was approximately $1.1 million, $0.8 million, and $1.1 million, for the years ended December 31, 2017, 2016, and 2015, respectively. As of December 31, 2017 and 2016, the purchase of property, plant, and equipment of $6.7 million and $2.9 million, respectively, were included in accounts payable and accrued liabilities. As of December 31, 2017 and 2016, the Company had $2.3 million and $2.6 million, respectively, in capitalized manufacturing equipment that is intended to be used specifically for the manufacture of Primatene ® Mist. The Company will continue to monitor developments with the FDA as it relates to its Primatene ® indefinite lived intangible assets in determining if there is an impairment of these related fixed assets (see Note 9).

Debt

Debt	12 Months Ended
	Dec. 31, 2017
Debt
Debt	Note 12. Debt Debt consists of the following: December 31, 2017 2016 (in thousands) Loans with East West Bank Equipment loan paid off April 2017 $ — $ 433 Line of credit facility due December 2018 — — Equipment loan due January 2019 1,668 3,208 Mortgage payable due February 2021 3,577 3,660 Equipment loan due June 2021 4,286 2,882 Equipment line of credit due December 2022 — — Mortgage payable due October 2026 3,524 3,582 Mortgage payable due June 2027 8,936 — Loans with Cathay Bank Line of credit facility due May 2018 — — Acquisition loan due April 2019 15,073 17,079 Mortgage payable due August 2027 7,795 4,367 Loans with Seine-Normandie Water Agency French government loan 1 due March 2018 30 French government loan 2 due June 2020 99 French government loan 3 due July 2021 262 Payment Obligation to Merck 599 506 Equipment under Capital Leases 1,357 1,614 Total debt and capital leases 47,156 37,722 Less current portion of long-term debt and capital leases 6,312 5,366 Long-term debt and capital leases, net of current portion $ 40,844 $ 32,356 Loans with East West Bank Equipment Loan—Paid off April 2017 In March 2012, the Company entered into an $8.0 million line of credit facility. In March 2013, the Company converted the outstanding principal balance of $4.9 million into an equipment loan. Borrowings under the facility were secured by equipment. Borrowings under the facility bore a variable interest rate at the prime rate as published by The Wall Street Journal plus 0.25%, with a minimum interest rate of 3.50%. In April 2017, the Company repaid all outstanding amounts due under this loan. Line of Credit Facility—Due December 2018 In March 2012, the Company entered into a $10.0 million line of credit facility, which bears a variable interest rate at the prime rate as published by The Wall Street Journal . Borrowings under the facility are secured by inventory and accounts receivable. This facility matured in March 2016. In March 2016, the facility was amended to increase the line of credit to $15.0 million and to extend the maturity date to September 2017. In May 2017, the Company amended the facility to extend the maturity date to December 2018. As of December 31, 2017, the Company did not have any amounts outstanding under this facility. Equipment Loan—Due January 2019 In July 2013, the Company entered into an $8.0 million line of credit facility. In January 2015, the Company drew down $6.2 million from the line of credit facility. Subsequently, the facility was converted into a term equipment loan with an outstanding principal balance of $6.2 million and a maturity date of January 2019. Borrowings under the facility are secured by equipment. As of December 31, 2017, the fair value of the loan approximates its book value. The interest rate used in the fair value estimation was determined to be a Level 2 input. The Company has entered into a fixed interest rate swap contract on this facility to exchange the variable interest rate for a fixed interest rate of 4.48% over the life of the facility without the exchange of the underlying notional debt amount. The interest rate swap contract does not qualify for hedge accounting, and is recorded at fair value for an immaterial amount based on Level 2 inputs. Mortgage Payable—Due February 2021 The Company refinanced the mortgage term loan in January 2016, which had an outstanding principal balance of $3.7 million at December 31, 2015, and a maturity date of February 2021. The refinanced loan is payable in monthly installments with a final balloon payment of $3.3 million. The refinanced loan is secured by one of the buildings at the Company’s Rancho Cucamonga, California, headquarters complex. The refinanced loan has a variable interest rate at the prime rate as published by The Wall Street Journal . As of December 31, 2017, the fair value of the loan approximates its book value. The interest rate used in the fair value estimation was determined to be a Level 2 input. The Company has entered into a fixed interest rate swap contract on this loan to exchange the variable interest rate for a fixed interest rate of 4.39% over the life of the loan without the exchange of the underlying notional debt amount. The interest rate swap contract does not qualify for hedge accounting, and is recorded at fair value for an immaterial amount based on Level 2 inputs. Equipment Loan–Due June 2021 In March 2016, the Company entered into a $5.0 million equipment credit facility. In May 2017, the Company converted the outstanding balance of $5.0 million into a term equipment loan which matures in June 2021. Borrowings under the loan are secured by equipment. The loan bears a variable interest rate at the prime rate as published by The Wall Street Journal. As of December 31, 2017, the fair value of the loan approximates its book value. The interest rate used in the fair value estimation was determined to be a Level 2 input. The Company has entered into a fixed interest rate swap contract on this facility to exchange the variable interest rate for a fixed interest rate of 4.86% over the life of the facility without the exchange of the underlying notional debt amount. The interest rate swap contract does not qualify for hedge accounting and is recorded at fair value for an immaterial amount based on Level 2 inputs. Equipment Credit Line—Due December 2022 In June 2017, the Company entered into an $8.0 million equipment credit line with an 18-month draw down period. Interest payments are due monthly through December 2018 at the prime rate as published by The Wall Street Journal. After the draw down period, the outstanding principal balance converts into a 48-month term loan which bears a variable interest rate at the prime rate as published by The Wall Street Journal. The loan matures in December 2022, and the principal and interest payments are due monthly. Borrowings under the facility are secured by equipment. As of December 31, 2017, the Company did not have any amounts outstanding under this facility. Mortgage Payable—Due October 2026 In September 2006, the Company entered into a mortgage term loan in the principal amount of $2.8 million, which matured in September 2016. The Company refinanced the mortgage term loan in September 2016, which increased the principal amount to $3.6 million and extended the maturity date to October 2026. The refinanced loan is payable in monthly installments with a final balloon payment of $2.9 million. The refinanced loan was secured by one of the buildings at the Company’s Rancho Cucamonga, California, headquarters complex. The refinanced loan bears a variable interest rate at the one-month LIBOR rate plus 2.75%. As of December 31, 2017, the fair value of the loan approximates its book value. The interest rate used in the fair value estimation was determined to be a Level 2 input. Subsequently, the Company entered into a fixed interest rate swap contract on this loan to exchange the variable interest rate for a fixed interest rate of 4.15% until October 2021 without the exchange of the underlying notional debt amount. The interest rate swap contract does not qualify for hedge accounting, and is recorded at fair value for an immaterial amount based on Level 2 inputs. Mortgage Payable—Due June 2027 In May 2017, the Company entered into a mortgage term loan in the principal amount of $9.0 million, which matures in June 2027. The loan is payable in monthly installments with a final balloon payment of $7.4 million plus interest. The loan is secured by one of the buildings at the Company’s Rancho Cucamonga, California, headquarters complex and two buildings at the Company’s Chino, California, facility. The loan bears a variable interest rate at the one-month LIBOR rate plus 2.5%. As of December 31, 2017, the fair value of the loan approximates its book value. The interest rate used in the fair value estimation was determined to be a Level 2 input. The Company entered into a fixed interest rate swap contract on this loan to exchange the variable interest rate for a fixed interest rate of 4.79% until June 2024 without the exchange of the underlying notional debt amount. The interest rate swap contract does not qualify for hedge accounting, and is recorded at fair value of approximately $0.1 million based on Level 2 inputs. Loans with Cathay Bank Line of Credit Facility—Due May 2018 In April 2012, the Company entered into a $20.0 million revolving line of credit facility. Borrowings under the facility are secured by inventory, accounts receivable, and intangibles held by the Company. The facility bears a variable interest rate at the prime rate as published by The Wall Street Journal with a minimum interest rate of 4.00%. In June 2016, the Company amended the facility to extend the maturity date from May 2016 to May 2018. As of December 31, 2017, the Company did not have any amounts outstanding under this facility. Acquisition Loan with Cathay Bank—Due April 2019 On April 22, 2014, in conjunction with the Merck API Transaction, the Company entered into a secured term loan with Cathay Bank as lender. The principal amount of the loan is $21.9 million and bears a variable interest rate at the prime rate as published by The Wall Street Journal , with a minimum interest rate of 4.00%. Beginning on June 1, 2014, and through the maturity date April 22, 2019, the Company must make monthly payments of principal and interest based on the then outstanding amount of the loan amortized over a 120-month period. On April 22, 2019, all amounts outstanding under the loan become due and payable, which would be approximately $12.0 million based upon an interest rate of 4.00%. The loan is secured by 65% of the issued and outstanding shares of stock in AFP and certain assets of the Company, including accounts receivable, inventory, certain investment property, goods, deposit accounts, and general intangibles but not including the Company’s equipment and real property. As of December 31, 2017, the fair value of the loan approximates its book value. The interest rate used in the fair value estimation was determined to be a Level 2 input. The loan includes customary restrictions on, among other things, the Company’s ability to incur additional indebtedness, pay dividends in cash or make other distributions in cash, make certain investments, create liens, sell assets, and make loans. The loan also includes customary events of defaults, the occurrence and continuation of any of which provide Cathay Bank the right to exercise remedies against the Company and the collateral securing the loan. These events of default include, among other things, the Company’s failure to pay any amounts due under the loan, the Company’s insolvency, the occurrence of any default under certain other indebtedness or material agreements, and a final judgment against the Company that is not discharged in 30 days. Mortgage Payable—Due August 2027 In April 2014, the Company refinanced the mortgage term loan, which had a principal balance outstanding of $4.6 million. The loan was payable in monthly installments with a final balloon payment of $3.9 million. The loan was secured by the building at the Company’s Canton, Massachusetts location and bore interest at a fixed rate of 5.42% and was to have matured in April 2021. In August 2017, the Company refinanced the mortgage term loan, with a principal balance outstanding of $7.9 million. The loan is payable in monthly installments and is secured by the building at the Company’s Canton, Massachusetts location. The loan bears interest at a fixed rate of 4.70% for the first five years of the loan; thereafter, the loan bears a variable interest rate at the prime rate as published by The Wall Street Journal and matures in June 2027. As of December 31, 2017, the fair value of the loan approximates its book value. The interest rate used in the fair value estimation was determined to be a Level 2 input. Loans with Seine-Normandie Water Agency In January 2015, the Company entered into three French government loans with the Seine-Normandie water agency in the aggregate amount of €0.6 million, or $0.7 million, subject to currency exchange fluctuations. The life of the loans range between three to six years, and includes annual equal payments and bears no interest over the life of the loans. As of December 31, 2017, the payment obligation had an aggregate book value of €0.3 million, or $0.3 million, subject to currency exchange rate fluctuations, which approximates fair value. The fair value of the payment obligation was determined by using the interest rate associated with the Company’s acquisition loan with Cathay Bank that bears a variable interest rate at the prime rate as published by The Wall Street Journal , with a minimum interest rate of 4.00%. Such interest rate is deemed to be a Level 2 input for measuring fair value. Payment Obligation to Merck Merck—Due December 2018 On April 30, 2014, in conjunction with the Merck API Transaction, the Company entered into a commitment obligation with Merck, in the principal amount of €11.6 million, or $16.0 million, subject to currency exchange rate fluctuations. The terms of the purchase price include annual payments over four years and bear a fixed interest rate of 3.00%. As of December 31, 2017, the payment obligation had a balance of €0.5 million, or $0.6 million, which approximates fair value. The fair value of the payment obligation was determined by using the interest rate associated with the Company’s acquisition loan with Cathay Bank that bears a variable interest rate at the prime rate as published by The Wall Street Journal , with a minimum interest rate of 4.00%. Such interest rate is deemed to be a Level 2 input for measuring fair value. Covenants At December 31, 2017 and 2016, the Company was in compliance with its debt covenants, which include a minimum current ratio, minimum debt service coverage, minimum tangible net worth, maximum debt-to-effective-tangible-net-worth ratio, and minimum deposit requirement computed on a consolidated basis. The fixed charge coverage ratio and debt service coverage ratio requirements for loans with Cathay Bank were not effective as of December 31, 2017. Such requirements will become effective as of December 31, 2018. Equipment under Capital Leases The Company entered into leases for certain equipment under capital leasing arrangements, which will expire at various times through 2022. The cost of equipment under capital leases was $1.6 million and $2.0 million at December 31, 2017 and 2016, respectively. Long-Term Debt Maturities As of December 31, 2017, the principal amounts of long-term debt maturities during each of the next five fiscal years ending December 31 are as follows: Capital Debt Leases Total (in thousands) 2018 $ 5,985 $ 327 2019 14,915 341 2020 1,806 339 2021 4,400 269 2022 450 156 Thereafter 18,168 — $ 45,724 $ 1,432 $ 47,156

Income Taxes

Income Taxes	12 Months Ended
	Dec. 31, 2017
Income Taxes
Income Taxes	Note 13. Income Taxes The Tax Cuts and Jobs Act, or the Tax Act, was enacted on December 22, 2017. The Tax Act, among other things, reduces the U.S. federal corporate tax rate from 35 percent to 21 percent effective January 1, 2018, and requires companies to pay a one-time transition tax on earnings of certain foreign subsidiaries that were previously tax deferred. At December 31, 2017, the Company has not completed its accounting for the tax effects of the enactment of the Tax Act; however, the Company has made a reasonable estimate of the effects on its existing deferred tax balances and the one-time transition tax on earnings of certain foreign subsidiaries that were previously tax deferred. The Company remeasured its deferred tax assets and liabilities based on the rates at which they are expected to reverse in the future. The provisional amount recorded related to the remeasurement was not material. The Company has analyzed the earnings and profits, or E&P, of its foreign subsidiaries since the Company’s inception and concluded that no provisional amount is required for the one-time transition tax liability. The Company’s provisional calculations of the one-time transition tax and deferred tax remeasurement are subject to developing interpretations of the legislation, changes to certain estimates and amounts related to the E&P of certain subsidiaries, and the filing of its tax returns. The final analysis will be completed over a one-year measurement period ending December 22, 2018, and any adjustments during this measurement period will be included in net earnings from continuing operations as an adjustment to income tax expense in the reporting period when such adjustments are determined. The Company’s income (loss) before income taxes generated from its United States and foreign operations were: Year Ended December 31, 2017 2016 2015 (in thousands) Income (loss) before income taxes: United States $ 7,266 $ 20,888 $ (4,344) Foreign (5,643) (5,942) (6,020) Total income (loss) before taxes $ 1,623 $ 14,946 $ (10,364) The Company’s provision (benefit) for income taxes consisted of the following: Year Ended December 31, 2017 2016 2015 (in thousands) Current provision (benefit): Federal $ (6,380) $ 7,279 $ 82 State 133 344 73 Foreign 643 787 (112) Total current provision (benefit) (5,604) 8,410 43 Deferred provision (benefit): Federal 5,824 (2,491) (5,222) State (2,140) (1,066) (1,250) Foreign (965) (439) (1,148) Total deferred provision (benefit) 2,719 (3,996) (7,620) Total provision (benefit) for income taxes $ (2,885) $ 4,414 $ (7,577) A reconciliation of the statutory federal income tax rate to the Company’s effective tax rate is as follows: Year Ended December 31, 2017 2016 2015 Statutory federal income tax (benefit) 35.0 % 35.0 % (35.0) % State tax expense, net of federal tax benefit (80.5) (3.1) (7.4) Foreign tax rate differences 3.0 1.8 (1.1) Foreign valuation allowance 99.4 14.4 (23.3) Qualified production activities deduction 69.0 (8.7) — Research and development credits (192.6) (11.7) (15.4) Share-based compensation (128.0) 3.0 7.7 Executive compensation 13.2 — — Deferred tax remeasurement (1.1) — — Employee-related expenses 4.8 0.4 0.7 Other (0.1) (1.6) 0.7 Effective tax rate (benefit) (177.9) % 29.5 % (73.1) % Deferred Tax Assets and Liabilities Deferred income taxes reflect the tax effects of temporary differences between the carrying amounts of assets and liabilities for financial reporting purposes and the amounts used for income tax purposes, tax credit carryforwards, and the tax effects of net operating loss carryforwards. The significant components of the Company’s deferred tax assets and liabilities are as follows: December 31, 2017 2016 (in thousands) Deferred tax assets: Net operating loss carryforward $ 7,356 $ 4,698 State income taxes 221 393 Inventory capitalization and reserve 5,333 7,368 Accrued payroll and benefits 1,233 1,813 Share-based compensation 6,504 10,545 Research and development credits 21,550 9,668 Alternative minimum tax 656 895 Accrued professional fees 344 1,333 Product return allowance 1,879 1,758 Accrued chargebacks 1,856 15,158 Bad debt reserve 60 95 Intangibles 2,022 3,370 Accrued for workers’ compensation insurance 1,063 1,409 Others 52 — Total deferred tax assets 50,129 58,503 Deferred tax liabilities: Depreciation/amortization 8,821 13,763 Intangibles 6,992 8,208 Federal impact of state deferred taxes 3,025 3,784 Other — 158 Total deferred tax liabilities 18,838 25,913 Valuation allowance (4,907) (3,044) Net deferred tax assets $ 26,384 $ 29,546 Effective January 1, 2017, the Company adopted ASU No. 2016-09, under which, differences between the tax deduction for share-based awards and the related compensation expenses recognized under ASC 718 are prospectively accounted for as a component of the provision for income taxes. In addition, ASU No. 2016-09 eliminated the requirement that excess tax benefits from share-based compensation reduce taxes payable prior to being recognized in the financial statements. As a result of the adoption of ASU No. 2016-09, the cumulative excess benefits of stock compensation of $0.9 million that was not previously recognized was established on the balance sheet resulting in an increase in deferred tax assets and retained earnings. Net Operating Loss Carryforwards and Tax Credits At December 31, 2017, the Company had no material U.S. federal net operating loss, or NOL, carryforwards and California and other state NOL carryforwards of approximately $17.2 million and $0.8 million, respectively, which begin to expire in 2030 and 2034, respectively. The Company had foreign NOL carryforwards of approximately $20.6 million which can be used annually with certain limitations and have an indefinite carryforward period. At December 31, 2017, the Company had federal and California research and development tax credit carryforwards of approximately $10.6 million and $16.2 million, respectively. The federal research and development tax credit begins to expire in 2032. The California research and development tax credit has an indefinite carryforward period. The Company also had a U.S. federal alternative minimum tax, or AMT, credit carryforward of $0.5 million which can be used to offset future regular tax to the extent of the current AMT; the credit has an indefinite carryforward period. The utilization of NOL and credit carryforwards and other tax attributes could be subject to an annual limitation under Sections 382 and 383 of the Internal Revenue Code of 1986 (the “Code”), whereby they could be limited in the event a cumulative change in ownership of more than 50% occurs within a three-year period as defined in the Code. Valuation Allowance In assessing the need for a valuation allowance, management considers whether it is more likely than not that some portion or all of the deferred tax assets will be realized. Ultimately, the realization of deferred tax assets depends on the existence of future taxable income. M anagement considers sources of taxable income such as income in prior carryback periods, future reversal of existing deferred taxable temporary differences, tax-planning strategies, and projected future taxable income. As of December 31, 2015, the Company assessed the realizability of the deferred tax assets of AFP and determined that it was not more likely than not that the net deferred tax assets of AFP would be realized. Therefore, the Company established a full valuation allowance of $0.9 million as of December 31, 2015. The Company has discontinued recognizing AFP income tax benefits until it is determined that it is more likely than not that AFP will generate sufficient taxable income to realize its deferred income tax assets. As of December 31, 2017 and 2016, the Company had a full valuation allowance against the net deferred tax assets of AFP, which totaled $4.9 million and $3.0 million, respectively. Undistributed Losses from Foreign Operations As of December 31, 2017 and 2016, deferred income taxes have not been provided on the accumulated undistributed losses of the Company’s foreign subsidiaries of approximately $15.9 million and $14.9 million, respectively. It is the Company’s plan not to repatriate future foreign earnings to the U.S. Uncertain Income Tax Positions A reconciliation of the beginning and ending balances of unrecognized tax benefits is as follows: December 31, 2017 2016 2015 (in thousands) Balance at the beginning of the year $ 6,686 $ 5,595 $ 4,783 Additions based on tax positions related to prior years — 188 — Additions based on tax positions related to the current year 1,300 903 812 Deductions based on statute of limitations (548) — — Balance at the end of the year $ 7,438 $ 6,686 $ 5,595 Included in the balance of unrecognized tax benefits as of December 31, 2017, was $6.4 million that represents the portion that would impact the effective income tax rate if recognized. The Company believes that it is reasonably possible that the total amount of unrecognized tax benefit as of December 31, 2017, will decline by $1.9 million in the next 12 months as a result of the expected resolution of a current U.S. state audit. The Company recognizes accrued interest and penalties related to unrecognized tax benefits in its income tax provision. For the years ended December 31, 2017 and 2016, the Company recognized accrued interest of approximately $0.1 million and $0.3 million, respectively, related to its uncertain tax positions. The Company and/or one or more of its subsidiaries filed income tax returns in the U.S. federal jurisdiction and various U.S. states and foreign jurisdictions. As of December 31, 2017, the Company is not subject to U.S. federal, state, and foreign income tax examinations for years before 2007. In June 2017, the Internal Revenue Service, or IRS, commenced an audit of the Company’s 2015 income tax return. Subsequent to December 31, 2017, the IRS completed the examination resulting in no changes to reported tax. In August 2011, the California Franchise Tax Board commenced an audit of the Company’s 2007, 2008, and 2009 tax returns; this audit is currently ongoing. The Company is subject to income tax audit by tax authorities for tax years 2014, 2015, and 2016 for federal and 2007 to 2016 for states.

Stockholders' Equity

Stockholders' Equity	12 Months Ended
	Dec. 31, 2017
Stockholders' Equity
Stockholders' Equity	Note 14. Stockholders' Equity Common and Preferred Stock The Company’s Certificate of Incorporation, as amended and restated in June 2014 in connection with the closing of its initial public offering, authorizes the Company to issue 300,000,000 shares of common stock, $0.0001 par value per share, and 20,000,000 shares of preferred stock, $0.0001 par value per share. As of December 31, 2017 and 2016, there were no shares of preferred stock issued or outstanding. Equity Plans As of December 31, 2017, the Company has two equity plans: the 2015 Equity Incentive Award Plan, or 2015 Plan, and the 2014 Employee Stock Purchase Plan or ESPP. Prior to the adoption of these plans, the Company granted options pursuant to the Amended and Restated 2005 Equity Incentive Award Plan and the 2002 Amended and Restated Stock Option/Stock Issuance Plan. Upon termination of the predecessor plans, the shares available for grant at the time of termination, and shares subsequently returned to the plans upon forfeiture or option termination, were transferred to the successor plan in effect at the time of share return. The Company issues new shares of common stock upon exercise of stock options, vesting of restricted stock units, or RSU, and settlement of ESPP, with the exception of the awards granted to employees at AFP, which are settled through re-issuance of the Company’s treasury shares. The 2015 Equity Incentive Plan In March 2015, the Board of Directors adopted the Company’s 2015 Equity Incentive Plan, or the 2015 Plan, which was approved by the Company’s stockholders in May 2015 and is set to expire in March 2025. The 2015 Plan is designed to meet the needs of a publicly traded company, including the requirements for granting “performance based compensation” under Section 162(m) of the Internal Revenue Code. The 2015 Plan provides for the grant of incentive stock options, nonstatutory stock options, restricted stock, restricted stock units, stock appreciation rights, performance units, performance shares, and other stock or cash awards to employees of the Company and its subsidiaries, members of the Board of Directors and consultants. The Company initially reserved 5,000,000 shares of common stock for issuance under the 2015 Plan. This number will be increased by the number of shares available for issuance under the Company’s prior equity incentive plans or arrangements that are not subject to options or other awards, plus the number of shares of common stock related to options or other awards granted under the Company’s prior equity incentive plans or arrangements that are repurchased, forfeited, expired, or cancelled on or after the effective date of the 2015 Plan. The 2015 Plan also contains an “evergreen provision” that allows for an annual increase in the number of shares available for issuance on January 1 of each year during the 10 year term of the 2015 Plan, beginning January 1, 2016. The annual increase in the number of shares shall be the lesser of (i) 3,000,000 shares, (ii) two and one-half percent ( 2.5% ) of the outstanding shares on the last day of the immediately preceding fiscal year, or (iii) such number of shares as determined by the Board of Directors. As of the effective date, there were 5,300,296 shares available for grant under the 2015 Plan. As of December 31, 2017, the Company reserved an aggregate of 4,626,894 shares of common stock for future issuance under the 2015 Plan. In January 2018, an additional 1,165,590 shares were reserved under the 2015 Plan pursuant to the evergreen provision. Amended and Restated 2005 Equity Incentive Award Plan The Amended and Restated 2005 Equity Incentive Award Plan, or 2005 Plan, provided for the grant of incentive stock options, or ISOs, nonqualified stock options, or NQSOs, restricted stock awards, restricted stock unit awards, stock appreciation rights, or SARs, dividend equivalents and stock payments to the Company’s employees, members of the Board of Directors and consultants. Stock options under the 2005 Plan were granted with a term of up to ten years and at prices no less than the fair market value of the Company’s common stock on the date of grant. To date, stock options granted to existing employees generally vest over three to five years and stock options granted to new employees vest over four years. As of March 2015, consequent to the 2015 Plan becoming effective, awards were no longer being made under the 2005 Plan. 2014 Employee Stock Purchase Plan In June 2014, the Company adopted the ESPP in connection with its initial public offering. A total of 2,000,000 shares of common stock are reserved for issuance under this plan. The Company’s ESPP permits eligible employees to purchase common stock at a discount through payroll deductions during defined offering periods. Under the ESPP, the Company may specify offerings with durations of not more than 27 months, and may specify shorter purchase periods within each offering. Each offering will have one or more purchase dates on which shares of its common stock will be purchased for employees participating in the offering. An offering may be terminated under certain circumstances. The price at which the stock is purchased is equal 85% of the lower of the fair market value of the common stock at the beginning of an offering period or on the date of purchase. As of December 31, 2017, the Company has issued 374,227 shares of common stock under the ESPP and 1,625,773 shares of its common stock remained available for issuance under the ESPP. For the year ended December 31, 2017, 2016, and 2015, the Company recorded ESPP expense of $0.6 million, $0.5 million, and $0.4 million, respectively. Share Buyback Program On November 6, 2014, the Company’s Board of Directors authorized a $10.0 million share buyback program, which was completed in December 2015. On November 10, 2015, the Company’s Board of Directors authorized an additional $10.0 million to the Company’s share buyback program, which was completed in December 2016. On November 7, 2016, the Company’s Board of Directors authorized an increase of $20.0 million to the Company’s share buyback program, which was completed in August 2017. On August 7, 2017, the Company’s Board of Directors authorized an additional $20.0 million to the Company’s share buyback program, which is expected to continue for an indefinite period of time. The primary goal of the program is to offset dilution created by the Company’s equity compensation programs. Purchases are made through open market and private block transactions pursuant to Rule 10b5-1 plans, privately negotiated transactions or other means as determined by the Company’s management and in accordance with the requirements of the SEC. The timing and actual number of treasury share purchases will depend on a variety of factors including price, corporate and regulatory requirements, and other conditions. These treasury share purchases are accounted for under the cost method and are included as a component of treasury stock in the Company’s consolidated balance sheets. Pursuant to the Company’s share buyback program, the Company purchased 1,905,653 shares, 759,067 shares, and 735,679, shares of its common stock during the years ended December 31, 2017, 2016 and 2015, totaling $30.7 million, $9.9 million, and $9.9 million, respectively. Share-Based Award Activity and Balances The Company accounts for share‑based compensation payments in accordance with ASC 718, which requires measurement and recognition of compensation expense at fair value for all share‑based payment awards made to employees and directors. Under these standards, the fair value of option awards and the option components of the ESPP awards are estimated at the grant date using the Black-Scholes option-pricing model. The fair value of RSUs is estimated at the grant date using the Company’s common share price. Non‑vested stock options held by non-employees are revalued at each balance sheet date. The portion that is ultimately expected to vest is amortized and recognized in compensation expense on a straight-line basis over the requisite service period, generally from the grant date to the vesting date. Options issued under the Company’s 2015 Plan and 2005 Plan, are granted at exercise prices equal to or greater than the fair value of the underlying common shares on the date of grant and vest based on continuous service. There have been no awards with performance conditions and no awards with market conditions. The options have a contractual term of five to ten years and generally vest over a three- to five‑year period. The Black‑Scholes option pricing model has various inputs such as the common share price on the date of grant, exercise price, the risk‑free interest rate, volatility, expected life and dividend yield, all of which are estimates. The Company records share‑based compensation expense net of expected forfeitures. The change of any of these inputs could significantly impact the determination of the fair value of the Company’s options as well as significantly impact its results of operations. The significant assumptions used in the Black-Scholes option-pricing are as follows: · Determining Fair Value of the underlying common stock. For options and ESPP awards granted after the completion of the Company’s initial public offering, the fair value for its underlying common stock is determined using the closing price on the date of grant as reported on the Nasdaq Global Select Market. Since the Company’s common stock was not traded in a public stock market exchange prior to June 25, 2014, prior to such date the Board of Directors considered numerous factors including recent cash sales of the Company’s common stock to third-party investors, new business and economic developments affecting the Company and independent appraisals, when appropriate, to determine the fair value of the Company’s common stock. Independent appraisal reports were prepared using conventional valuation techniques, such as discounted cash flow analyses and the guideline company method using revenue and earnings multiples for comparable publicly traded companies, and a calculation of total option proceeds, from which a discount factor for lack of marketability was applied. This determination of the fair value of the common stock was performed on a contemporaneous basis. Prior to the Company’s initial public offering, the Board of Directors determined the Company’s common stock fair market value on a quarterly basis and in some cases more frequently when appropriate. · Expected Volatility. The Company has limited data regarding company‑specific historical or implied volatility of its share price. Consequently, the Company estimates its volatility based on the weighted average historical volatility of our stock price since IPO and the stock price from a set of peer companies, since our shares do not have sufficient trading history. Management considers factors such as stage of life cycle, competitors, size, market capitalization and financial leverage in the selection of similar entities. · Expected Term. The expected term represents the period of time in which the options granted are expected to be outstanding. The Company estimates the expected term of options with consideration of vesting date, contractual term, and historical experience for exercise and post-vesting employment or contractual termination behavior after its common stock has been publicly traded. The expected term of “plain vanilla” options is estimated based on the midpoint between the vesting date and the end of the contractual term under the simplified method permitted by the SEC implementation guidance. The weighted‑average expected term of the Company’s options is approximately five years. · Risk‑Free Rate. The risk‑free interest rate is selected based upon the implied yields in effect at the time of the option grant on U.S. Treasury zero‑coupon issues with a term approximately equal to the expected life of the option being valued. · Dividends. The Company does not anticipate paying cash dividends in the foreseeable future. Consequently, the Company uses an expected dividend yield rate of zero. The Company estimates forfeitures at the time of grant and revises those estimates in subsequent periods if actual experience differs from those estimates. For the years ended December 31, 2017, 2016 and 2015, the Company estimated an average overall forfeiture rate of 7%, 7%, and 8%, respectively, based on historical experience. Forfeiture rates are separately estimated for its (1) directors and officers, (2) management personnel and (3) other employees. Share‑based compensation is recorded net of expected forfeitures. The Company periodically assesses the forfeiture rate and the amount of expense recognized based on estimated historical forfeitures as compared to actual forfeitures. Changes in estimates are recorded in the period they are identified. Tax benefits resulting from tax deductions in excess of the share‑based compensation cost recognized (excess tax benefits) are recorded in the statements of cash flows as financing activities. The weighted-averages for key assumptions used in determining the fair value of options granted during the years ended December 31, 2017, 2016, and 2015 are as follows: Year Ended December 31, 2017 2016 2015 Average volatility 37.0 % 30.4 % 27.1 % Risk-free interest rate 2.1 % 1.5 % 1.3 % Weighted-average expected life in years 5.5 5.5 4.5 Dividend yield rate — % — % — % Stock Options A summary of option activity under all plans for the year ended December 31, 2017, is presented below: Weighted-Average Weighted-Average Remaining Aggregate Exercise Contractual Intrinsic Options Price Term (Years) Value (1) (in thousands) Outstanding as of December 31, 2016 12,530,297 $ 14.57 Options granted 1,815,813 14.23 Options exercised (2,958,473) 11.80 Options cancelled (46,858) 13.67 Options expired (442,078) 29.96 Outstanding as of December 31, 2017 10,898,701 $ 14.65 4.95 $ 56,370 Exercisable as of December 31, 2017 6,588,460 $ 15.32 3.53 $ 32,185 (1) The aggregate intrinsic value is calculated as the difference between the exercise price of the underlying awards and the Company’s common stock for those awards that have an exercise price below the estimated fair value at December 31, 2017. During the years ended December 31, 2017, 2016, and 2015, the Company recorded expense of $7.7 million, $8.0 million, and $7.9 million, respectively, related to stock options granted to employees under all plans, and expenses of $0.6 million, $0.7 million, and $0.5 million, respectively, related to stock options granted to the Board of Directors under all plans. Information relating to option grants and exercises is as follows: Year Ended December 31, 2017 2016 2015 (in thousands, except per share data) Weighted-average grant date fair value per option share $ 4.98 $ 3.42 $ 3.45 Intrinsic value of options exercised 17,247 7,446 3,247 Cash received from options exercised 19,098 20,338 13,502 Total fair value of the options vested during the year 7,263 8,654 6,634 A summary of the status of the Company’s nonvested options as of December 31, 2017, and changes during the year ended December 31, 2017, are presented below: Weighted-Average Grant Date Options Fair Value Non-vested as of December 31, 2016 4,592,187 $ 3.61 Options granted 1,815,813 4.98 Options vested (2,050,901) 3.54 Options forfeited (46,858) 4.76 Non-vested as of December 31, 2017 4,310,241 4.21 As of December 31, 2017, there was $11.1 million of total unrecognized compensation cost, net of forfeitures, related to nonvested stock option based compensation arrangements granted under all plans. The cost is expected to be recognized over a weighted-average period of 2.1 years and will be adjusted for future changes in estimated forfeitures. Restricted Stock Units The Company grants restricted stock units, or RSUs, to certain employees and members of the Board of Directors with a vesting period of up to five years. The grantee receives one share of common stock at a specified future date for each RSU awarded. The RSUs may not be sold or otherwise transferred until certificates of common stock have been issued, recorded, and delivered to the participant. The RSUs do not have any voting or dividend rights prior to the issuance of certificates of the underlying common stock. The share-based expense associated with these grants was based on the Company’s common stock fair value at the time of grant and is amortized over the requisite service period, which generally is the vesting period, using the straight-line method. During the years ended December 31, 2017, 2016, and 2015, the Company recorded expenses of $7.1 million, $5.2 million, and $3.4 million, respectively, related to RSU awards granted to employees under all plans, and expenses of $0.6 million, $0.7 million, and $0.5 million, respectively, related to RSU awards granted to the Board of Directors. As of December 31, 2017, there was $12.3 million of total unrecognized compensation cost, net of forfeitures, related to non-vested RSU-based compensation arrangements granted under all plans. The cost is expected to be recognized over a weighted-average period of 2.3 years and will be adjusted for future changes in estimated forfeitures. Information relating to RSU grants and deliveries is as follows: Total Fair Market Value of RSUs Issued Total RSUs as Issued Compensation (1) (in thousands) RSUs outstanding at December 31, 2016 1,215,786 RSUs granted 679,024 $ 9,346 RSUs forfeited (16,231) RSUs vested (2) (485,798) RSUs outstanding at December 31, 2017 1,392,781 (1) The total FMV is derived from the number of RSUs granted times the current stock price on the date of grant. (2) Of the vested RSUs, 184,699 shares of common stock were surrendered to fulfil tax withholding obligations Equity Awards to Consultants and Advisory Board Members The Company pays certain consultants and advisory board members in the form of share-based awards. Such share- based compensation expense is recorded over the service period based on the estimated fair market value of the equity award at the date services are performed or upon completion of services. During the years ended December 31, 2017, 2016, and 2014 the Company recorded $0.5 million, $0.1 million, and $0.2 million, respectively, in share-based compensation related to the issuance of equity awards for services rendered by consultants. The Company recorded share-based compensation expense under all plans and is included in the Company’s consolidated statement of operations as follows: Year Ended December 31, 2017 2016 2015 (in thousands) Cost of revenues $ 3,756 $ 2,967 $ 2,526 Operating expenses: Selling, distribution, and marketing 302 220 192 General and administrative 11,643 10,865 9,185 Research and development 1,386 1,072 912 Total share-based compensation $ 17,087 $ 15,124 $ 12,815

Employee Benefits

Employee Benefits	12 Months Ended
	Dec. 31, 2017
Employee Benefits
Employee Benefits	Note 15. Employee Benefits 401(k) Plan The Company has a defined contribution 401(k) plan, or the Plan, whereby eligible employees voluntarily contribute up to a defined percentage of their annual compensation. The Company matches contributions at a rate of 50% on the first 6% of employee contributions, and pays the administrative costs of the Plan. Employer contributions vest over four years. Total employer contributions for the years ended December 31, 2017, 2016, and 2015 were approximately $1.1 million, $1.0 million, and $0.7 million, respectively. Defined Benefit Pension Plan In connection with the Merck API Transaction, the Company assumed an obligation associated with a defined-benefit plan for eligible employees of AFP. This plan provides benefits to the employees from the date of retirement and is based on the employee’s length of time employed by the Company. The calculation is based on a statistical calculation combining a number of factors that include the employee’s age, length of service, and AFP employee turnover rate. The liability under the plan is based on a discount rate of 1.60% and 1.75% as of December 31, 2017 and 2016, respectively. The liability is included in accrued liabilities in the accompanying consolidated balance sheets. The plan is currently unfunded, and the benefit obligation under the plan was $2.1 million and $1.7 million at December 31, 2017 and 2016, respectively. Expense under the plan was $0.2 million, $0.2 million, and $0.1 million for the years ended December 31, 2017, 2016, and 2015, respectively. Gain or loss due to change in actuarial valuation of the Company’s defined benefit pension plan is recorded in other comprehensive income (loss).

Commitments and Contingencies

Commitments and Contingencies	12 Months Ended
	Dec. 31, 2017
Commitments and Contingencies
Commitments and Contingencies	Note 16. Commitments and Contingencies Supply Agreement with MannKind Corporation On July 31, 2014, the Company entered into a supply agreement with MannKind Corporation, or MannKind, or the Supply Agreement, pursuant to which the Company agreed to manufacture for and supply to MannKind certain quantities of RHI API for use in MannKind’s product Afrezza ® . Under the Supply Agreement, MannKind agreed to purchase annual minimum quantities of RHI API in an aggregate amount of approximately €120.1 million, or approximately $146.0 million, over five years from calendar years 2015 through 2019. Specifically, the minimum annual purchase commitment was approximately €27.1 million in 2015, and approximately €23.3 million each year from 2016 through 2019. In January 2015, the Company entered into a supply option agreement with MannKind, or the Option Agreement, pursuant to which MannKind has the option to purchase RHI API, in excess of the minimum amounts specified in the Supply Agreement in calendar years 2016 through 2019. In the event MannKind elects not to exercise its minimum annual purchase option for any year under the Option Agreement, MannKind is obligated to pay the Company a specified capacity cancellation fee. In October 2015, MannKind informed the Company that it was not exercising the option to purchase additional quantities of RHI API for 2016 under the Option Agreement and paid the Company the specified capacity cancellation fee of $0.8 million. Such capacity cancellation fee was recorded as net revenue in the Company’s consolidated statement of operations for the year ended December 31, 2015. For the year ended December 31, 2016, sales of RHI API to MannKind totaled $6.8 million, which fulfilled the remaining unfulfilled 2015 commitment of RHI under the Supply Agreement. In November 2016, the Company amended the Supply Agreement with MannKind, whereby MannKind’s aggregate total commitment of RHI API under the Supply Agreement has not been reduced; however, the annual minimum purchase commitments of RHI API under the Supply Agreement have been modified and extended through 2023, which timeframe had previously lapsed after calendar year 2019. Specifically, the minimum annual purchase commitment in calendar year 2016 has been cancelled, and the minimum annual purchase commitments in calendar years 2017 through 2023 have been modified to be €2.7 million of insulin in the fourth quarter of 2017, €8.9 million in 2018, €11.6 million in 2019, €15.5 million in 2020 and in 2021, and €19.4 million in 2022 and in 2023. MannKind may request to purchase additional quantities of RHI API in excess of its annual minimum purchase commitments. The Supply Agreement Amendment also (i) shortened the required expiry dates for RHI API delivered to MannKind pursuant to the Supply Agreement, (ii) modified the timing of MannKind’s payment for the minimum annual purchase commitment in calendar year 2017, and (iii) added a pre-payment requirement for purchases of RHI API by MannKind in calendar years 2017 and 2018. The amendment can be renewed for additional, successive two-year terms upon 12 months’ written notice, given prior to the end of the initial term or any additional two-year term. For the year ended December 31, 2017, sales of RHI API to MannKind totaled $3.2 million, which fulfilled the 2017 commitment of RHI API under the amended Supply Agreement. Concurrent with the amendment of the Supply Agreement, the Company amended the Option Agreement with MannKind, whereby the amendment to the Option Agreement extends the timing for payment of the capacity cancellation fee for 2017 and decreases the amounts payable as capacity cancellation fees for 2018 and 2019 in the event MannKind fails to exercise its minimum annual purchase option for any given year. The Company recognized the cancellation fee for 2017 of $1.5 million in net revenues in its consolidated statement of operations for the year ended December 31, 2016. In August 2017, MannKind notified the Company that it would not exercise its minimum annual purchase option of RHI API for 2018. The Company recognized the cancellation fee for 2018 of $0.9 million in net revenues in its consolidated statements of operations for the year ended December 31, 2017. In addition to, and in consideration for the updated timeframe and other changes contained in the amendment to the Supply Agreement and the amendment to the Option Agreement, the Supply Agreement Amendment provided the Company right of first refusal to participate in the development and commercialization of Afrezza ® in China through a collaborative arrangement. Collaboration Agreements with Medical Device Manufacturers In August 2014, the Company entered into a collaboration agreement with a medical device manufacturer to develop a drug delivery system to be used by the Company for one of its pipeline products. As of December 31, 2017, the Company has paid an upfront payment of $0.5 million and has paid $1.5 million in milestone payments under this agreement, which were classified as research and development expense, as the milestones were met. The Company is obligated to pay up to an additional $0.5 million if certain research and development milestones are met. As of December 31, 2017, no such obligation existed. Pursuant to the collaboration agreement, if the medical device manufacturer is successful in the development of this drug delivery system and the Company’s pipeline products receive appropriate regulatory approval, the Company intends to enter into a commercial supply agreement with such medical device manufacturer for a minimum purchase of 1.0 million units during the first 12 months. In October 2017, the Company entered into a collaboration agreement with a medical device manufacturer to develop a drug delivery system to be used by the Company for one of its pipeline products for a total of $1.6 million. As of December 31, 2017, the Company is obligated to pay $0.4 million, and up to an additional $1.2 million, if certain research and development milestones are met. As of December 31, 2017, no such obligation existed for the milestones. In addition, pursuant to the collaboration agreement, if the medical device manufacturer is successful in the development of this drug delivery system and the Company’s pipeline products receive appropriate regulatory approval, the Company intends to enter into a commercial supply agreement with such medical device manufacturer under which the Company is obligated to pay an additional $1.0 million, if certain commercial development milestones are met and to purchase a minimum of 100,000 units per year for three years. Operating Lease Agreements The Company leases real and personal property, in the normal course of business, under various non-cancelable operating leases. The Company, at its option, can renew a substantial portion of its leases, at the market rate, for various renewal periods ranging from one to six years. Rental expense under these leases for the years ended December 31, 2017, 2016, and 2015, was approximately $3.5 million, $3.4 million, and $3.3 million, respectively. Future minimum rental payments under operating leases that have initial or remaining non-cancelable lease terms in excess of 12 months for fiscal years ending December 31 are as follows: Operating Leases (in thousands) 2018 $ 3,333 2019 2,624 2020 2,321 2021 1,523 2022 740 $ 10,541 Purchase Commitments As of December 31, 2017, the Company has entered into commitments to purchase equipment and raw materials for an aggregate amount of approximately $50.1 million. The Company anticipates that most of these commitments with remaining term in excess of one year will be fulfilled by 2019. In addition, the Company is obligated to pay a supplier certain payments up to $1.5 million based on the sale of one of the Company’s product. The Company entered into agreements with a Chinese governmental entity to acquire land-use rights to real property in Nanjing, China. Under the terms of these agreements, the Company committed to invest capital in its wholly-owned subsidiary, ANP, and to develop these properties as an API manufacturing facility for the Company’s pipeline products. In conjunction with these agreements, ANP modified its business license on July 3, 2012, to increase its authorized capital. As of December 31, 2016, the Company had completed its investment of total registered capital commitment of $61.0 million to ANP. This investment in ANP resulted in cash being transferred from the U.S. parent company to ANP. Per these agreements, in January 2010, the Company acquired certain land-use rights with a carrying value of $1.2 million. In addition, the Company purchased additional land-use rights in November 2012 for $1.3 million. The Company committed to spend approximately $15.0 million in land development. The agreements require the construction of fixed assets on the property and specified a timetable for the construction of these fixed assets. The current pace of development of the property is behind the schedules described in the purchase agreements and, per the purchase agreements, potential monetary penalties could result if the development is delayed or not completed in accordance with the guidelines stated in the purchase agreements. The Company is in discussions with the Chinese government regarding the development and believes that the likelihood of incurring any penalty is remote.

Litigation

Litigation	12 Months Ended
	Dec. 31, 2017
Litigation
Litigation	Note 17. Litigation Enoxaparin Patent Litigation In September 2011, Momenta Pharmaceuticals, Inc., or Momenta, a Boston‑based pharmaceutical company, and Sandoz Inc., or Sandoz, the generic division of Novartis, initiated litigation against the Company for alleged patent infringement of two patents related to testing methods for batch release of enoxaparin, which the Company refers to as the “‘886 patent” and the “‘466 patent.” The lawsuit was filed in the United States District Court for the District of Massachusetts, or the Massachusetts District Court. In October 2011, the Massachusetts District Court issued a preliminary injunction barring the Company from selling its generic enoxaparin product and also requiring Momenta and Sandoz to post a $100.1 million bond. The preliminary injunction was stayed by the United States Court of Appeals for the Federal Circuit, or the Federal Circuit, in January 2012, and reversed by the Federal Circuit in August 2012. In January 2013, the Company moved for summary judgment of non‑infringement of both patents. Momenta and Sandoz withdrew their allegations as to the ‘466 patent, and in July 2013, the Massachusetts District Court granted the Company’s motion for summary judgment of non‑infringement of the ‘886 patent and denied Momenta and Sandoz’s motion for leave to amend their infringement contentions. On January 24, 2014, the Massachusetts District Court judge entered final judgment in the Company’s favor on both patents. Momenta and Sandoz also filed a motion to collect attorneys’ fees and costs relating to a discovery motion, which the Massachusetts District Court granted. On May 9, 2016, the Massachusetts District Court issued an order imposing fees and costs of approximately $0.4 million in relation to this discovery motion. This amount has been accrued in the general and administrative expense for the quarter ended March 31, 2016 . On January 30, 2014, Momenta and Sandoz filed a notice of appeal to the Federal Circuit appealing the court’s final judgment including summary judgment denying Momenta and Sandoz’s motion for leave to amend their infringement contentions. Following appeal briefing filed by the parties, t he Federal Circuit held oral argument on May 4, 2015. On November 10, 2015, the Federal Circuit panel affirmed-in-part and vacated-in-part the decision of the Massachusetts District Court granting summary judgment of non-infringement as to the Company, and it remanded the case to the Massachusetts District Court for further proceedings consistent with its opinion. The Federal Circuit panel affirmed the Massachusetts District Court’s holding in the Company’s favor that the Company does not infringe under 35 U.S.C. 271(g), and the panel vacated the grant of summary judgment to the extent it was based on the determination that the Company’s activities fall within the 35 U.S.C. 271(e)(1) safe harbor. The Federal Circuit panel also left to the Massachusetts District Court’s discretion whether to reconsider on remand its denial of leave for Momenta and Sandoz to amend their infringement contentions. On January 11, 2016, the Company filed a Petition for Rehearing En Banc with the Federal Circuit. On February 17, 2016, the Federal Circuit denied the Company’s Petition, and the Federal Circuit issued its mandate on February 24, 2016, whereby the case returned to the Massachusetts District Court for further proceedings. On March 18, 2016, the parties filed a joint status report with the Massachusetts District Court. On June 21, 2016, the Massachusetts District Court granted Momenta and Sandoz’s Motion for Leave to Amend its Infringement Contentions. In light of Momenta and Sandoz’s Amended Infringement Contentions and recent changes in Supreme Court precedent since the case was stayed in 2012, the Company sought to amend its Non-Infringement and Invalidity Contentions. On July 18, 2016, the Company submitted its Motion for Leave to Amend Its Non-Infringement and Invalidity Contentions and Momenta and Sandoz responded on July 25, 2016. In light of the new arguments made in their response, the Company further filed a Motion For Leave to Reply in Further Support of Defendants’ Motion for Leave to Amend Non-Infringement and Invalidity Contentions, which was granted. A hearing was held on August 23, 2016, where the Magistrate Judge ordered the Company to file its proposed amended contentions, which it filed on August 31, 2016. On February 4, 2017, the Magistrate Judge issued an order denying the Company leave to amend its contentions. The Company filed objections to this order with the District Court on February 21, 2017. On April 13, 2017, the District Court rejected the determination of the Magistrate Judge with respect to the Company’s amended non-infringement contentions, and allowed the Company to amend its non-infringement contentions. With respect to the Company’s amended invalidity contentions, the District Court accepted the Magistrate Judge’s determination; however, the District Court specifically stated that the Company can argue changes in law at the summary judgment stage or at trial. In parallel with the Massachusetts District Court proceedings, the Company appealed the Federal Circuit’s decision to vacate the grant of the Company’s summary judgment to the extent it was based on the determination that the Company’s activities are protected under the Safe Harbor. The Company filed a Petition for a Writ of Certiorari with the Supreme Court on May 17, 2016. Momenta and Sandoz initially waived their right to respond to the petition; however, on May 31, 2016, the Supreme Court requested a response from Momenta and Sandoz. The response from Momenta and Sandoz was initially due on June 30, 2016, but they requested an extension. Momenta and Sandoz filed their response on August 1, 2016. On October 3, 2016, the Supreme Court declined the Petition for a Writ of Certiorari. Fact discovery in the Massachusetts District Court proceedings closed on November 22, 2016, and the parties proceeded with expert discovery and exchanged opening and rebuttal expert reports. Expert discovery closed on March 24, 2017. On April 14, 2017, Plaintiffs filed a Motion for Summary Judgment seeking to dismiss the Company’s equitable defenses. On April 14, 2017, the Company filed Defendants’ Motion for Summary Judgment of Invalidity and Noninfringement. In the Motion, the Company moved for the District Court to grant summary judgment in favor of the Company on the following issues: (1) the ’886 patent is invalid under 35 U.S.C. § 101 as claiming non-patentable subject matter; (2) the ’886 patent is invalid under 35 U.S.C. § 112 because the claims are indefinite; and (3) the Company’s tests do not infringe the claims of the ’886 patent. Oppositions to the motions for summary judgment were filed on May 5, 2017. Replies in support of the motions for summary judgment were filed on May 19, 2017. On June 16, 2017, the District Court issued an order denying the summary judgment motions. The District Court also denied Plaintiffs’ motion for summary judgment dismissing the Company’s defenses of implied waiver and equitable estoppel, and denied Plaintiffs’ alternative request for a separate hearing on the implied waiver and equitable estoppel defenses holding that the defenses would be submitted to the jury for an advisory verdict. Trial in the Massachusetts District Court on all claims and defenses began on July 10, 2017. On July 21, 2017, the jury returned a unanimous verdict finding that although the Company’s tests infringed the asserted patent, the patent was invalid for lack of enablement and lack of written description and the jury further found that Plaintiffs are entitled to zero ($0) damages. As for the Company’s defenses of implied waiver and equitable estoppel, the jury found that Plaintiffs waived their right to recover for infringement of the asserted patent and that Plaintiffs are estopped from enforcing the asserted patent against the Company. The verdict on these equitable defenses was briefed by the parties and submitted to the Court. In the post-trial briefing, the Company requested the Court to adopt the findings of the jury on the equitable defenses, and to set aside the jury’s finding of infringement. In Plaintiffs’ post-trial briefing, Plaintiffs requested a new trial, and requested the Court to set aside the jury’s finding that the asserted patent was invalid for lack of enablement and lack of written description. In a February 7, 2018 Memorandum and Order and with respect to the equitable defenses, the Court found that Plaintiffs waived their right to enforce the ‘866 patent against the Company for its use of one of its test, and are equitably estopped from enforcing the ‘866 patent against the Company for its use of that same test. The Court also found that Plaintiffs have not waived their right to enforce the ‘866 patent against the Company for its use of a second test, and are not equitable estopped from enforcing the ‘866 patent against the Company for its use of that same second test. On February 7, 2018, the Court also denied all other post-trial motions. The Company has requested that the Court enter final judgment in this matter reflecting the jury’s verdict and the Court’s February 7, 2018 Memorandum and Order. The Company will continue to vigorously defend the jury’s verdict, including against any potential appeal by the Plaintiffs . The Company intends to attempt to collect the $100.1 million bond posted by Momenta and Sandoz following a final judgment by the Massachusetts District Court. False Claims Act Litigation In January 2009, the Company filed a qui tam complaint in the U.S. District Court for the Central District of California, or the California District Court, alleging that Aventis Pharma S.A., or Aventis, through its acquisition of a patent through false and misleading statements to the U.S. Patent and Trademark Office, as well as through false and misleading statements to the FDA, overcharged the federal and state governments for its Lovenox ® product. If the Company is successful in this litigation, it could be entitled to a portion of any damage award that the government ultimately may recover from Aventis. In October 2011, the California District Court unsealed the Company’s complaint. On February 28, 2014, Aventis filed a motion for summary judgment on the issue of the adequacy of the Company’s notice letter to the government, and the California District Court denied Aventis’ motion for summary judgment in a final order it issued on May 12, 2014. On June 9, 2014, at Aventis’ request, the California District Court issued an order certifying for appeal its order denying Aventis’ motion for summary judgment. On June 9, 2014, Aventis filed with the United States Court of Appeals for the Ninth Circuit, or the Ninth Circuit, a petition for permission to appeal the California District Court’s denial of Aventis’ motion for summary judgment, and the Company filed an opposition to Aventis’ petition on June 19, 2014. On August 22, 2014, the Ninth Circuit granted Aventis’ petition. The parties filed their respective appeal briefs with the Ninth Circuit. On November 10, 2016, the Ninth Circuit heard oral argument on the appeal. The California District Court set an evidentiary hearing for July 7, 2014 on the “original source” issue, a key element under the False Claims Act. The evidentiary hearing was conducted as scheduled, from July 7, 2014 through July 10, 2014. On July 13, 2015, the California District Court issued a ruling concluding that the Company is not an original source under the False Claims Act, and entered final judgment dismissing the case for lack of subject matter jurisdiction. On July 20, 2015, the Company filed with the Ninth Circuit a notice of appeal of the California District Court’s dismissal of the case, and Aventis filed a notice of cross-appeal on August 5, 2015. On November 12, 2015, Aventis filed a pleading asking that the California District Court impose various monetary penalties and fines against the Company, including disgorgement of enoxaparin revenues and attorneys’ fees expended by Aventis in this action, based on Aventis’s allegations that the Company engaged in sanctionable conduct. On November 23, 2015, the California District Court issued an order setting forth a procedure for sanctions proceedings as to the Company as well as its outside counsel. On December 24, 2015, the Company filed a pleading with the California District Court opposing the imposition of sanctions, and on January 20, 2016, Aventis filed a response pleading further pressing for the imposition of sanctions. On May 4, 2016, the California District Court issued three orders requesting that the Company and its outside counsel file a document showing cause as to why sanctions should not be imposed and to set up a conference call with the partiers and the court to discuss whether any discovery and/or a hearing is necessary. On June 13, 2016, the Company and its outside counsel each filed responses to the court’s order to show cause as to why sanctions should not be imposed. On July 21, 2016, Aventis filed a response contending that the court should impose sanctions. On February 10, 2017, the Court held a show cause hearing regarding the potential imposition of sanctions and took the matter under submission. On September 18, 2017, the District Court issued its decision that no sanctions will be imposed on either the Company or its counsel. On March 28, 2016, the Company filed its opening brief with the Ninth Circuit Court of Appeals setting forth detailed arguments as to why the False Claims Act litigation should not have been dismissed by the California District Court. On June 20, 2016, Aventis filed its principal brief in the appeal, responding to the Company’s arguments regarding dismissal of the False Claims Act litigation, and setting forth Aventis’s argument that it should be awarded attorneys’ fees and expenses. On September 19, 2016, the Company filed its reply brief to Aventis’s principal brief. On October 3, 2016, Aventis filed its reply brief in support of its cross-appeal of the District Court’s denial of attorneys’ fees. On November 10, 2016, the Ninth Circuit heard oral argument on the appeals. On May 11, 2017, the Ninth Circuit issued an opinion affirming the California District Court’s dismissal of the action for lack of subject matter jurisdiction; dismissing as moot Aventis’s appeal from the District Court’s denial of its motion for summary judgment on the issue of the adequacy of the Company’s notice letter to the government; reversing the District Court’s denial of Aventis’s motion for attorneys’ fees; and remanding the case to the District Court for resolution of the attorneys’ fees issue. On July 14, 2017, Aventis filed an application with the District Court for entitlement to attorneys’ fees and expenses. The Company intends to continue to vigorously defend against any such imposition of attorneys’ fees or sanctions. California Employment Litigation On January 6, 2015, the Company received a formal demand from Plaintiff’s counsel in an employment related lawsuit captioned Eva Hernandez v. International Medication Systems Limited, in connection with a complaint originally filed on February 4, 2013, in the Superior Court of California County of Los Angeles, or the Court, by plaintiff Eva Hernandez on behalf of herself and others similarly situated. Plaintiff’s complaint included alleged violations of the California Labor Code stemming from the Company’s alleged timekeeping practices, as well as other similar and related claims brought under California law. In the complaint, Plaintiff sought damages and related remedies under California law, as well as various penalty payments under the California Labor Code, on behalf of herself and others similarly situated. On April 7, 2015, solely to resolve the dispute, minimize disruption to the Company due to ongoing litigation, and other similar and related factors (but unrelated to the alleged merits of Plaintiff’s claims), the Company reached an agreement in principle to settle this matter on a class-wide basis for a total amount of $3.2 million, plus applicable payroll taxes. The Joint Stipulation of Settlement as executed by the parties was filed with the Court on June 2, 2015. On July 1, 2015, the Court preliminarily approved the settlement, and on November 5, 2015, the Court entered an order granting final approval of the settlement. On May 13, 2016, the court reviewed and approved the final distribution report. The case was removed from the Court’s Civil Active Case List. Momenta/Sandoz Antitrust Litigation On September 17, 2015, the Company initiated a lawsuit by filing a complaint in the California District Court against Momenta and Sandoz, or the Defendants. The Company’s complaint generally asserts that Defendants have engaged in certain types of illegal, monopolistic, and anticompetitive conduct giving rise to various causes of action against them. On December 9, 2015, Defendants filed a motion to dismiss and a motion to transfer the case to the District of Massachusetts. On January 4, 2016, the Company filed oppositions to both motions. On January 26, 2016, the California District Court granted Defendants’ motion to transfer and did not rule on Defendants’ motion to dismiss. Accordingly, the case was transferred to the District of Massachusetts. On February 9, 2016, the Company filed a writ of mandamus with the Ninth Circuit to attempt to appeal the California District Court’s granting of Defendants’ motion to transfer to the District of Massachusetts. The Ninth Circuit denied this petition on May 20, 2016, and as such the case will remain before the District of Massachusetts. On July 27, 2016, the Massachusetts District Court granted Defendants’ motion to dismiss based on antitrust immunity doctrine, without addressing the substantive merits of the claims. On August 25, 2016, the Company filed with the First Circuit Court of Appeals a notice of appeal of the Massachusetts District Court’s dismissal of the antitrust case. On April 6, 2017, the District Court held a status conference to address scheduling matters for the rest of the case. The Court set a briefing schedule for Defendants’ supplemental motion to dismiss and a full case schedule in the event that it denies Defendants’ supplemental motion to dismiss. On April 20, 2017, Defendants filed their supplemental motion to dismiss and the Company filed its opposition on May 4, 2017. No reply briefs are allowed. The Court promised to rule on the motion to dismiss by the end of May 2017, but has not yet issued a ruling. The parties filed a joint motion for extension of time to complete discover on January 10, 2018. The Court has not yet ruled on the motion to extend the case schedule. The parties have begun discovery related to the litigation. Under the proposed schedule, fact discovery will close on October 1, 2018. Summary judgment arguments would be due on April 26, 2019; oppositions would be due on June 14, 2019; and replies would be due on July 10, 2019. Trial is currently proposed for September 30, 2019. Other Litigation The Company is also subject to various other claims and lawsuits from time-to-time arising in the ordinary course of business. The Company records a provision for contingent losses when it is both probable that a liability has been incurred and the amount of the loss can be reasonably estimated. In the opinion of management, the ultimate resolution of any such matters is not expected to have a material adverse effect on its financial position, results of operations, or cash flows; however, the results of litigation and claims are inherently unpredictable and the Company’s view of these matters may change in the future. Regardless of the outcome, litigation can have an adverse impact on the Company because of defense and settlement costs, diversion of management resources, and other factors.

Quarterly Financial Data (Unaud

Quarterly Financial Data (Unaudited)	12 Months Ended
	Dec. 31, 2017
Quarterly Financial Data
Quarterly Financial Data	Note 18. Quarterly Financial Data (Unaudited) 2017 Quarters First Second Third Fourth (in thousands, except per share data) Net revenues Finished pharmaceutical products $ 55,934 $ 63,765 $ 54,455 $ 55,985 API 736 1,422 3,461 4,417 Total net revenues $ 56,670 $ 65,187 $ 57,916 $ 60,402 Gross profit Finished pharmaceutical products $ 24,310 $ 28,866 $ 21,310 $ 22,317 API (1,482) (2,119) (669) (1,738) Total gross profit $ 22,828 $ 26,747 $ 20,641 $ 20,579 Net income $ 893 $ 1,972 $ 175 $ 1,468 Weighted-average shares used to compute net income per share Basic 46,069 46,025 46,101 46,233 Diluted 48,057 47,866 48,215 49,330 Net income per share Basic $ 0.02 $ 0.04 $ 0.00 $ 0.03 Diluted $ 0.02 $ 0.04 $ 0.00 $ 0.03 2016 Quarters First Second Third Fourth (in thousands, except per share data) Net revenue Finished pharmaceutical products $ 58,554 $ 63,756 $ 59,058 $ 58,853 API 812 4,277 5,165 4,690 Total net revenues $ 59,366 $ 68,033 $ 64,223 $ 63,543 Gross profit Finished pharmaceutical products $ 25,824 $ 30,598 $ 28,621 $ 21,057 API (922) 1,116 (1,009) (1,096) Total gross profit $ 24,902 $ 31,714 $ 27,612 $ 19,961 Net income (loss) $ 2,489 $ 6,895 $ 3,890 $ (2,742) Weighted-average shares used to compute net income (loss) per share Basic 45,041 44,957 45,398 46,104 Diluted 46,810 45,968 47,953 46,104 Net income (loss) per share Basic $ 0.06 $ 0.15 $ 0.09 $ (0.06) Diluted $ 0.05 $ 0.15 $ 0.08 $ (0.06) Net income (loss) per share amounts for the fiscal quarters have been calculated independently and may not in the aggregate equal the amount for the full year.

Summary of Significant Accoun26

Summary of Significant Accounting Policies (Policies)	12 Months Ended
	Dec. 31, 2017
Summary of Significant Accounting Policies
Basis of Presentation	Basis of Presentation The accompanying consolidated financial statements include the accounts of the Company and its wholly-owned subsidiaries, and are prepared in accordance with accounting principles generally accepted in the United States, or GAAP. Certain amounts in the prior years’ consolidated statements of operations and consolidated balance sheets have been reclassified to conform to the current year presentation. This reclassification has no impact on net income or cash flows. All significant intercompany activity has been eliminated in the preparation of the consolidated financial statements. Effective January 1, 2017, the Company prospectively adopted certain requirements of Accounting Standards Update, or ASU, No. 2016-09 to classify cash flows related to excess tax benefits in operating activities and directly record all excess tax benefits and tax deficiencies in income tax expense or benefit in the consolidated statement of operations without adjusting prior periods. The Company’s subsidiaries include: (1) International Medication Systems, Limited, or IMS, (2) Armstrong Pharmaceuticals, Inc., or Armstrong, (3) Amphastar Nanjing Pharmaceuticals Inc., or ANP, (4) Nanjing Letop Fine Chemistry Co., Ltd., or Letop, (5) Nanjing Hanxin Medical Technology Co., Ltd., or Hanxin, (6) Nanjing Baixin Trading Co., Ltd., or Baixin, (7) Amphastar France Pharmaceuticals, S.A.S., or AFP, (8) Amphastar UK Ltd., or AUK, and (9) International Medication Systems (UK) Limited, or IMS UK.
Use of Estimates	Use of Estimates The preparation of consolidated financial statements in accordance with GAAP requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and accompanying notes. Actual results could differ from those estimates. The principal accounting estimates include: determination of allowances for doubtful accounts and discounts, provision for chargebacks and rebates, provision for product returns, adjustment of inventory to their net realizable values, impairment of long-lived and intangible assets and goodwill, self-insured claims, workers’ compensation liabilities, litigation reserves, stock price volatilities for share-based compensation expense, valuation allowances for deferred tax assets, and liabilities for uncertain income tax positions.
Foreign Currency	Foreign Currency The functional currency of the Company, its domestic subsidiaries, its Chinese subsidiary, ANP, and its U.K. subsidiary, AUK, is the U.S. dollar, or USD. ANP maintains its books of record in Chinese Yuan. These books are remeasured into the functional currency of USD using the current or historical exchange rates. The resulting currency remeasurement adjustments and other transactional foreign currency exchange gains and losses are reflected in the Company’s statements of operations. The Company’s French subsidiary, AFP, maintains its books of record in Euros. Its other Chinese subsidiaries, maintain their books of record in Chinese Yuan. Its U.K. subsidiary, IMS UK, maintains its books of record in Great Britain Pounds. These local currencies have been determined to be the subsidiaries’ respective functional currencies. These books of records are translated into USD using average exchange rates during the period. Assets and liabilities are translated at the rate of exchange prevailing on the balance sheet date. Equity is translated at the prevailing rate of exchange at the date of the equity transactions. Translation adjustments are reflected in stockholders’ equity and are included as a component of other accumulated comprehensive income (loss). The unrealized gains or losses of intercompany foreign currency transactions that are of a long-term investment nature are reported in other accumulated comprehensive income (loss). The unrealized gains and losses of intercompany foreign currency transactions that are of a long-term investment nature for the years ended December 31, 2017, 2016, and 2015 were a $4.3 million gain, $1.5 million loss, and a $2.0 million loss, respectively. Additionally, the Company does not undertake hedging transactions to cover its foreign currency exposure.
Comprehensive Income (Loss)	Comprehensive Income (loss) For the years ended December 31, 2017, 2016 and 2015, the Company included its foreign currency translation gain or loss and change in pension obligation of its defined benefit pension plan as part of its comprehensive income (loss) . Income tax expense of $1.5 million was allocated to other comprehensive income for the year ended December 31, 2017. There was no material income tax expense (benefit) allocated to other comprehensive loss for the years ended December 31, 2016 and 2015.
Shipping and Handling Costs	Shipping and Handling Costs For the years ended December 31, 2017, 2016, and 2015, the Company included shipping and handling costs of approximately $3.0 million, $2.4 million, and $2.6 million, respectively, in selling, distribution and marketing expenses in the accompanying consolidated statements of operations.
Research and Development Costs	Research and Development Costs Research and development costs are charged to expense as incurred and consist of costs incurred to further the Company’s research and development activities including salaries and related employee benefits, costs associated with clinical trials, nonclinical research and development activities, regulatory activities, research‑related overhead expenses and fees paid to external service providers. The Company may produce or purchase inventories prior to or with the expectation of receiving marketing authorization in the near term, based on operational decisions about the most effective use of existing resources. This inventory is referred to as pre‑launch inventory. It is the Company’s accounting policy that the pre-launch inventory is capitalized if it has a probable future economic benefit. If marketing authorization is received and previously expensed pre‑launch inventory is sold, such sales may contribute up to a 100% margin to the Company’s operating results. Pre‑launch inventory costs include cost of work in process, materials, and finished drug products. As of December 31, 2017, 2016, and 2015, the Company did not have material capitalized pre-launch inventory.
Financial Instruments	Financial Instruments The carrying amounts of cash and cash equivalents, short-term investments, restricted cash and short-term investments, accounts receivable, accounts payable, accrued expenses, and short-term borrowings approximate fair value due to the short maturity of these items. The majority of the Company’s long-term obligations consist of variable rate debt, and their carrying value approximates fair value as the stated borrowing rates are comparable to rates currently offered to the Company for instruments with similar maturities. However, the Company has one fixed-rate, long-term mortgage for which the carrying value differs from the fair value and is not remeasured on a recurring basis (see Note 12). The Company at times enters into fixed interest rate swap contracts to exchange the variable interest rates for fixed interest rates without the exchange of the underlying notional debt amounts. Such interest rate swap contracts are recorded at their fair values.
Cash and Cash Equivalents	Cash and Cash Equivalents Cash and cash equivalents consist of cash, money market accounts, certificates of deposit and highly liquid investments purchased with original maturities of three months or less.
Short-Term Investments	Short-Term Investments Short-term investments as of December 31, 2017 consisted of certificates of deposit with original expiration dates within 12 months.
Restricted Cash and Short-term Investments	Restricted Cash and Short-term Investments Restricted cash and short-term investments are collateral required for the Company to effect a standby letter of credit and to qualify for workers’ compensation self-insurance and are available to meet the Company’s workers’ compensation obligations on a current basis, as needed. As of December 31, 2017, restricted cash and short-term investments included $1.9 million in cash and $2.3 million in certificates of deposit. As of December 31, 2016, restricted cash and short-term investments include $1.4 million in certificates of deposit. The certificates of deposit have original maturities greater than three months and are classified as current assets.
Allowance for Doubtful Accounts Receivable	Allowance for Doubtful Accounts Receivable The Company evaluates the collectability of accounts receivable based on a combination of factors. When the Company is aware of circumstances that may impair a customer’s ability to pay subsequent to the original sale, the Company records a specific allowance to reduce the amounts receivable to the amount that the Company reasonably believes to be collectable. For all other customers, the Company recognizes an allowance for doubtful accounts based on factors that include the length of time the receivables are past due, industry and geographic concentrations, the current business environment and historical collection experience. As of December 31, 2017 and 2016, the Company's allowance for doubtful accounts was $0.3 million and $0.3 million, respectively.
Inventories	Inventories Inventories consist of currently marketed products and products manufactured under contract. Inventories are stated using the first-in, first-out method, on a consistent basis. In 2016, the Company prospectively adopted ASU No. 2015-11, Simplifying the Measurement Inventory, and states inventory at the lower of cost and net realizable value. Provisions are made for slow‑moving, unsellable, or obsolete items. Net realizable value is determined using the estimated selling price, in the ordinary course of business, less estimated costs to complete and dispose.
Property, Plant and Equipment	Property, Plant and Equipment Property, plant and equipment are stated at cost or, in the case of assets acquired in a business combination, at fair value on the purchase date. Depreciation and amortization expense is computed using the straight‑line method over the estimated useful lives of the related assets
Intangible Assets	Intangible Assets Intangible assets with finite lives are amortized using the straight-line method over the period the asset is expected to contribute directly or indirectly to the future cash flows of the Company
Impairment of Long Lived Assets, including Identifiable Definite-Lived Intangible Assets	Impairment of Long‑Lived Assets, including Identifiable Definite-Lived Intangible Assets The Company reviews long-term and identifiable definite-lived intangible assets or asset groups for impairment when events or changes in circumstances indicate that the carrying amount of an asset or asset group may not be recoverable. If the sum of the expected future undiscounted cash flows is less than the carrying amount of the asset or an asset group, further impairment analysis is performed. An impairment loss is measured as the amount by which the carrying amount of the asset or asset groups exceeds the fair value (assets to be held and used) or fair value less cost to sell (assets to be disposed of). The Company also reviews the useful lives of its assets periodically to determine whether events and circumstances warrant a revision to the remaining useful life. Changes in the useful life are adjusted prospectively by revising the remaining period over which the asset is amortized.
Deferred Income Taxes	Deferred Income Taxes The Company utilizes the liability method of accounting for income taxes, under which deferred taxes are determined based on the temporary differences between the financial statements and the tax basis of assets and liabilities using enacted tax rates. A valuation allowance is recorded when it is more likely than not that the deferred tax assets will not be realized. At December 31, 2017, the Company has not completed its accounting of certain areas for the tax effects of the enactment of the Tax Act.
Impairment of Indefinite-Lived Intangible Asset and Goodwill	Impairment of Indefinite-Lived Intangible Asset and Goodwill The Company reviews indefinite‑lived intangible asset and goodwill for impairment in the fourth quarter of each year or more frequently if indicators of impairment are present. When the Company chooses to perform a qualitative assessment, it evaluates economic, industry and company-specific factors as an initial step. If the Company determines it is more likely than not that the indefinite-lived intangible asset is impaired or the fair value of a reporting unit is less than its carrying amount, further quantitative impairment process is then performed; otherwise, no further testing is required. An impairment loss is recorded if the asset’s fair value is less than its carrying value. The Company also periodically reviews the indefinite-lived intangible asset to determine if events and circumstances continue to support an indefinite useful life. If the life is no longer indefinite, the asset is tested for impairment. The carrying value, after recognition of any impairment loss, is amortized over its remaining useful life.
Self-Insured Claims	Self-Insured Claims The Company is primarily self-insured, up to certain limits, for workers’ compensation claims. The Company has purchased stop-loss insurance, which will reimburse the Company for individual claims in excess of $350,000 annually or aggregate claims exceeding $2.6 million annually. Operations are charged with the cost of claims reported and an estimate of claims incurred but not reported. A liability for unpaid claims and the associated claim expenses, including incurred but not reported losses, is actuarially determined and reflected in accrued liabilities in the accompanying consolidated balance sheets. Total expense under the program was approximately $1.5 million, $1.6 million, and $1.2 million, for the years ended December 31, 2017, 2016 and 2015, respectively. The self-insured claims liability was $4.1 million and $3.5 million at December 31, 2017 and 2016, respectively. The determination of such claims and expenses and the appropriateness of the related liability is reviewed periodically and updated, as necessary. Changes in estimates are recorded in the period identified.
Business Combinations	Business Combinations If an acquired set of activities and assets is capable of being operated as a business consisting of inputs and processes from the viewpoint of a market participant, the asset acquired and liabilities assumed are a business. Business combinations are accounted for using the acquisition method of accounting, which requires an acquirer to recognize the assets acquired and the liabilities assumed at the acquisition date measured at their fair values as of that date. Fair value determinations are based on discounted cash flow analyses or other valuation techniques. In determining the fair value of the assets acquired and liabilities assumed in a material acquisition, the Company may utilize appraisals from third party valuation firms to determine fair values of some or all of the assets acquired and liabilities assumed, or may complete some or all of the valuations internally. In either case, the Company takes full responsibility for the determination of the fair value of the assets acquired and liabilities assumed. The value of goodwill reflects the excess of the fair value of the consideration conveyed to the seller over the fair value of the net assets received. Acquisition-related costs that the Company incurs to effect a business combination are expensed in the periods in which the costs are incurred. When the operations of the acquired businesses were not material to the Company’s consolidated financial statements, no pro forma presentations were disclosed.
Recent Accounting Pronouncements	Recent Accounting Pronouncements In May 2014, the Financial Accounting Standards Board, or FASB, issued Accounting Standard Update, or ASU, No. 2014-09 Revenue from Contracts with Customers , which creates a single source of revenue guidance for companies in all industries. Subsequently, the FASB issued multiple updates. The new standard provides guidance for all revenue arising from contracts with customers and affects all entities that enter into contracts to provide goods or services to their customers, unless the contracts are within the scope of other accounting standards. It also provides a model for the measurement and recognition of gains and losses on the sale of certain nonfinancial assets. The guidance also requires expanded disclosures relating to the nature, amount, timing, and uncertainty of revenue and cash flows arising from contracts with customers. Additionally, qualitative and quantitative disclosures are required regarding customer contracts, significant judgments and changes in judgments, and assets recognized from the costs to obtain or fulfill a contract. This guidance permits two methods of adoption: retrospectively to each prior reporting period presented (full retrospective method), or retrospectively with the cumulative effect of initially applying the guidance recognized at the date of initial application (the cumulative catch-up transition method). Based on ASU No. 2015-14 Deferral of the Effective Date , issued in August 2015, this guidance will be effective for the Company beginning in the first quarter of 2018, including interim periods within the year. The Company will adopt the standard in 2018 using the modified retrospective transition method. The Company’s revenue are generated from the sale of pharmaceutical products to various customers, and the adoption of the new standard will not have a material impact on these transactions or on the consolidated financial statements and related disclosures. In February 2016, the FASB issued ASU No. 2016-02 Leases , that is aimed at making leasing activities more transparent and comparable, and which requires substantially all leases be recognized by lessees on their balance sheets as a right-of-use asset and corresponding lease liability, including leases currently accounted for as operating leases. This guidance will become effective for the Company’s interim and annual reporting periods during the year ending December 31, 2019, and all annual and interim reporting periods thereafter. Early adoption is permitted. The Company is required to use a modified retrospective approach for leases that exist or are entered into after the beginning of the earliest comparative period in the financial statements for the reporting periods in which the guidance is adopted. While the Company continues to evaluate the provisions of ASC 842 to determine how it will be affected, the primary effect of adopting the new standard will be to record assets and obligations for current operating leases on its consolidated financial statements. Footnote 16 provides details on the Company’s current operating lease arrangements. The adoption of ASC 842 is not expected to have a material impact on the Company’s results of operations or cash flows. In June 2016, the FASB issued ASU No. 2016-13 Financial Instruments – Credit Losses , which is aimed at providing financial statement users with more useful information about the expected credit losses on financial instruments and other commitments to extend credit. The standard update changes the impairment model for financial assets measured at amortized cost, requiring presentation at the net amount expected to be collected. The measurement of expected credit losses requires consideration of a broader range of reasonable and supportable information to inform credit loss estimates. Available-for-sale debt securities with unrealized losses will be recorded through an allowance for credit losses. The guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2020. Early adoption is permitted for interim or annual periods after December 31, 2019. The Company will be required to apply the standard’s provisions as a cumulative-effect adjustment to retained earnings as of the beginning of the first reporting period in which the guidance is effective. The Company does not believe that the adoption of this accounting guidance will have a material impact on its consolidated financial statements and related disclosures. In August 2016, the FASB issued ASU No. 2016-15 Classification of Certain Cash Receipts and Cash Payments , which is aimed at addressing certain issues regarding classifications of certain cash receipts and cash payments on the statement of cash flows where diversity in practice was identified. The guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2018. Early adoption is permitted. The Company will be required to apply the guidance retrospectively in the first interim and each annual period in which the guidance is adopted. The Company does not believe that the adoption of this accounting guidance will have a material impact on the Company’s consolidated financial statements and related disclosures. In October 2016, the FASB issued ASU No. 2016-16 Intra-Entity Transfers of Assets Other Than Inventory , which requires an entity to recognize the income tax consequences of intra-entity transfer of an asset other than inventory when the transfer occurs. The guidance is effective for the Company's interim and annual reporting periods during the year ending December 31, 2018. Early adoption is permitted as of the beginning of an annual reporting period for which financial statements, interim or annual, have not been issued. The amendments will be applied on a modified retrospective basis through a cumulative-effect adjustment directly to retained earnings as of the beginning of the period of adoption. The Company is currently evaluating the impact that the adoption of this guidance will have on its consolidated financial statements and related disclosures. In November 2016, the FASB issued ASU No. 2016-18 Statement of Cash Flows: Restricted Cash , which requires entities to show the changes in the total of cash, cash equivalents, restricted cash and restricted cash equivalents in the statement of cash flows. As a result, the Company will no longer present transfers between cash and cash equivalents and restricted cash and restricted cash equivalents in the statement of cash flows. The guidance is effective for the Company's interim and annual reporting periods during the year ending December 31, 2018. Early adoption is permitted, including adoption in an interim period. The amendments will be applied using a retrospective transition method to each period presented. The Company will be required to apply the guidance retrospectively when adopted. The Company will adopt this accounting guidance at the beginning of 2018. In January 2017, the FASB issued ASU No. 2017-01 Clarifying the Definition of a Business , which provides guidance to assist entities with evaluating when a set of transferred assets and activities is a business. Under the updated guidance, a set is not a business if substantially all of the fair value of the gross assets acquired is concentrated in a single identifiable asset or a group of similar assets. If the threshold is not met, the update requires that, to be a business, the set must include, at a minimum, an input and a substantive process that together significantly contribute to the ability to create outputs. The definition of outputs was also aligned with Accounting Standard Codification, or ASC 606 by focusing on revenue-generating activities. The guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2018, and prospectively applicable to any transactions occurring within the period of adoption. Early adoption is permitted. The Company is currently evaluating the impact that the adoption of this guidance will have on its consolidated financial statements and related disclosures. In January 2017, the FASB issued ASU No. 2017-04 simplifying the Test for Goodwill Impairment , which eliminates the requirement to calculate the implied fair value of goodwill. An entity should perform its annual, or interim, goodwill impairment test by comparing the fair value of a reporting unit with its carrying amount. An entity should recognize an impairment charge for the amount by which the carrying amount exceeds the reporting unit’s fair value; however, the loss recognized should not exceed the total amount of goodwill allocated to that reporting unit. The update also eliminated the requirements for any reporting unit with a zero or negative carrying amount to perform a qualitative assessment and, if it fails that qualitative test, to perform Step 2 of the goodwill impairment test. An entity is required to disclose the amount of goodwill allocated to each reporting unit with a zero or negative carrying amount of net assets. The guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2020, and applied on a prospective basis. Early adoption is permitted for interim and annual goodwill impairment testing dates after January 1, 2017. The Company currently does not believe that the adoption of this accounting guidance will have a material impact on its consolidated financial statements and related disclosures. In May 2017, the FASB issued ASU No. 2017-09 Scope of Modification Accounting , that clarifies when changes to the terms or conditions of a share-based payment award must be accounted for as modifications. The new guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2018, and applied prospectively to awards modified on or after the adoption date. Early adoption is permitted. The Company does not believe that the adoption of this accounting guidance will have a material impact on its consolidated financial statements and related disclosures. In August 2017, the FASB issued ASU No. 2017-12 Targeted Improvements to Accounting for Hedging Activities , which amends the hedge accounting model in ASC 815 to enable entities to better portray the economics of their risk management activities in the financial statements and enhance the transparency and understandability of hedge results. The amendments also simplify the application of hedge accounting in certain situations. The new guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2019. Early adoption is permitted. The Company does not believe that the adoption of this accounting guidance will have a material impact on its consolidated financial statements and related disclosures. In February 2018, the FASB issued ASU No. 2018-02 Reclassification of Certain Tax Effects from Accumulated Other Comprehensive Income , which allows entities to reclassify from accumulated other comprehensive income to retained earnings stranded tax effects resulting from the Tax Cuts and Jobs Act of 2017. The guidance is effective for the Company’s interim and annual reporting periods during the year ending December 31, 2019. Early adoption is permitted. The Company does not believe that the adoption of this accounting guidance will have a material impact on its consolidated financial statements and related disclosures

Summary of Significant Accoun27

Summary of Significant Accounting Policies (Tables)	12 Months Ended
	Dec. 31, 2017
Summary of Significant Accounting Policies
Schedule of estimated useful life of property, plant and equipment	Buildings 20 - 31 years Machinery and equipment 2 - 12 years Furniture and fixtures 3 - 7 years Automobiles 4 - 5 years Leasehold improvements Lesser of remaining lease term or useful life
Schedule of estimated useful life of intangible assets	Product rights 5 - 15 years Patents 10 - 20 years Land-use rights 37 - 50 years
Schedule of accounts payable and accrued liabilities	December 31, 2017 2016 (in thousands) Accrued customer fees and rebates $ 15,981 $ 6,940 Accrued payroll and related benefits 15,680 13,847 Accrued product returns, current portion 4,133 1,800 Other accrued liabilities 5,132 5,027 Total accrued liabilities 40,926 27,614 Accounts payable 16,629 19,932 Total Accounts payable and accrued liabilities $ 57,555 $ 47,546

Revenue Recognition (Tables)

Revenue Recognition (Tables)	12 Months Ended
	Dec. 31, 2017
Revenue Recognition
Schedule of chargeback provision analysis	Year Ended December 31, 2017 2016 (in thousands) Beginning balance $ 39,709 $ 15,888 Provision for chargebacks and rebates 152,011 171,159 Credits and payments issued to third parties (173,250) (147,338) Ending balance $ 18,470 $ 39,709
Schedule of product return liability analysis	Year Ended December 31, 2017 2016 (in thousands) Beginning balance $ 3,143 $ 2,621 Provision for product returns 5,754 1,753 Credits issued to third parties (2,375) (1,231) Ending balance $ 6,522 $ 3,143

Income (Loss) per Share (Tables

Income (Loss) per Share (Tables)	12 Months Ended
	Dec. 31, 2017
Income (Loss) per Share
Schedule of basic and diluted net income (loss) per share calculation	Year Ended December 31, 2017 2016 2015 (in thousands, except per share data) Basic and dilutive numerator: Net income (loss) $ 4,508 $ 10,532 $ (2,787) Denominator: Weighted-average shares outstanding — basic 46,107 45,375 44,961 Net effect of dilutive securities: Incremental shares from equity awards 2,260 2,129 — Weighted-average shares outstanding — diluted 48,367 47,504 44,961 Net income (loss) per share — basic $ 0.10 $ 0.23 $ (0.06) Net income (loss) per share — diluted $ 0.09 $ 0.22 $ (0.06)

Segment Reporting (Tables)

Segment Reporting (Tables)	12 Months Ended
	Dec. 31, 2017
Segment Reporting
Schedule of financial information by reporting segment	Year Ended December 31, 2017 2016 2015 (in thousands) Net revenues: Finished pharmaceutical products $ 230,139 $ 240,221 $ 224,941 API 10,036 14,944 26,578 Total net revenues 240,175 255,165 251,519 Gross profit: Finished pharmaceutical products 96,803 106,100 74,146 API (6,008) (1,911) 3,201 Total gross profit 90,795 104,189 77,347 Operating expenses 91,690 88,497 84,245 Income (loss) from operations (895) 15,692 (6,898) Non-operating income (expenses) 2,518 (746) (3,466) Income (loss) before income taxes $ 1,623 $ 14,946 $ (10,364)
Schedule of net revenues in the finished pharmaceutical products segment	Year Ended December 31, 2017 2016 2015 (in thousands) Finished pharmaceutical products net revenues: Naloxone $ 42,342 $ 47,532 $ 38,602 Phytonadione 37,946 33,315 19,804 Lidocaine 37,602 36,600 30,260 Enoxaparin 36,593 59,320 84,502 Epinephrine 25,914 25,661 14,936 Other finished pharmaceutical products 49,742 37,793 36,837 Total finished pharmaceutical products net revenues $ 230,139 $ 240,221 $ 224,941
Schedule of net revenues and carrying values of long-lived assets by geographic region	Net Revenue Long-Lived Assets Year Ended December 31, December 31, 2017 2016 2015 2017 2016 (in thousands) United States $ 234,321 $ 249,007 $ 243,295 $ 110,235 $ 104,110 China — — — 41,078 35,085 France 5,854 6,158 8,224 34,026 13,659 United Kingdom — — — — 90 Total $ 240,175 $ 255,165 $ 251,519 $ 185,339 $ 152,944

Customer and Supplier Concent31

Customer and Supplier Concentration (Tables)	12 Months Ended
	Dec. 31, 2017
Customer and Supplier Concentration
Schedule of accounts receivable and net revenues by major customer	% of Total Accounts % of Net Receivable Revenue December 31, December 31, Year Ended December 31, 2017 2016 2017 2016 2015 Actavis (1) — 1 % — 14 % 21 % AmerisourceBergen 33 % 30 % 28 % 21 % 17 % Cardinal Health 12 % 28 % 23 % 22 % 17 % McKesson 22 % 19 % 27 % 21 % 22 %

Goodwill and Intangible Assets

Goodwill and Intangible Assets (Tables)	12 Months Ended
	Dec. 31, 2017
Goodwill and Intangible Assets
Schedule of weighted-average life, original cost, accumulated amortization and net book value by major class	Weighted-Average Accumulated Life (Years) Original Cost Amortization Net Book Value (in thousands) Definite-lived intangible assets Cortrosyn® product rights 12 $ 27,134 $ 26,243 $ 891 IMS (UK) international product rights (1) 10 9,440 1,337 8,103 Patents 12 486 170 316 Land-use rights 39 2,540 419 2,121 Other intangible assets 4 69 46 23 Subtotal 12 39,669 28,215 11,454 Indefinite-lived intangible assets Trademark * 29,225 — 29,225 Goodwill - Finished pharmaceutical products * 4,461 — 4,461 Subtotal * 33,686 — 33,686 As of December 31, 2017 * $ 73,355 $ 28,215 $ 45,140 Weighted-Average Accumulated Life (Years) Original Cost Amortization Net Book Value (in thousands) Definite-lived intangible assets Cortrosyn® product rights 12 $ 27,134 $ 24,461 $ 2,673 IMS (UK) international product rights (1) 10 8,632 359 8,273 Acquired ANDAs (2) 15 4,000 222 3,778 Patents 10 293 137 156 Land-use rights 39 2,540 354 2,186 Other intangible assets 1 574 534 40 Subtotal 12 43,173 26,067 17,106 Indefinite-lived intangible assets Trademark * 29,225 — 29,225 Goodwill - Finished pharmaceutical products * 3,976 — 3,976 Subtotal * 33,201 — 33,201 As of December 31, 2016 * $ 76,374 $ 26,067 $ 50,307 * Intangible assets with indefinite lives have an indeterminable average life. (1) In August 2016, the Company acquired International Medication Systems (UK) Limited from UCB PHARMA GmbH for $7.7 million. The fair value of the marketing authorization was $9.2 million as of the acquisition date (see Note 3). (2) In February 2017, the Company sold the 14 ANDAs it had acquired from Hikma to an unrelated party for $6.4 million.
Schedule of changes in carrying amounts of goodwill	December 31, 2017 2016 (in thousands) Beginning balance $ 3,976 $ 3,726 Goodwill related to acquisition of business — 391 Currency translation and other adjustments 485 (141) Ending balance $ 4,461 $ 3,976
Schedule of finite-lived intangible assets, future amortization expense	(in thousands) 2018 $ 1,772 2019 870 2020 864 2021 864 2022 844 Thereafter 6,240 Total amortizable intangible assets 11,454 Indefinite-lived intangibles 33,686 Total intangibles (net of accumulated amortization) $ 45,140

Inventories (Tables)

Inventories (Tables)	12 Months Ended
	Dec. 31, 2017
Inventories
Schedule of inventories	December 31, 2017 2016 (in thousands) Raw materials and supplies $ 19,973 $ 36,209 Work in process 22,469 22,266 Finished goods 21,167 21,279 Total inventories $ 63,609 $ 79,754

Property, Plant, and Equipment

Property, Plant, and Equipment (Tables)	12 Months Ended
	Dec. 31, 2017
Property, Plant, and Equipment
Schedule of property, plant, and equipment	December 31, 2017 2016 (in thousands) Buildings $ 89,124 $ 85,283 Leasehold improvements 29,847 24,619 Land 7,110 6,857 Machinery and equipment 118,056 111,041 Furniture, fixtures, and automobiles 16,385 15,113 Construction in progress 58,145 32,044 Total property, plant, and equipment 318,667 274,957 Less accumulated depreciation (133,328) (122,013) Total property, plant, and equipment, net $ 185,339 $ 152,944

Debt (Tables)

Debt (Tables)	12 Months Ended
	Dec. 31, 2017
Debt
Schedule of debt	December 31, 2017 2016 (in thousands) Loans with East West Bank Equipment loan paid off April 2017 $ — $ 433 Line of credit facility due December 2018 — — Equipment loan due January 2019 1,668 3,208 Mortgage payable due February 2021 3,577 3,660 Equipment loan due June 2021 4,286 2,882 Equipment line of credit due December 2022 — — Mortgage payable due October 2026 3,524 3,582 Mortgage payable due June 2027 8,936 — Loans with Cathay Bank Line of credit facility due May 2018 — — Acquisition loan due April 2019 15,073 17,079 Mortgage payable due August 2027 7,795 4,367 Loans with Seine-Normandie Water Agency French government loan 1 due March 2018 30 French government loan 2 due June 2020 99 French government loan 3 due July 2021 262 Payment Obligation to Merck 599 506 Equipment under Capital Leases 1,357 1,614 Total debt and capital leases 47,156 37,722 Less current portion of long-term debt and capital leases 6,312 5,366 Long-term debt and capital leases, net of current portion $ 40,844 $ 32,356
Schedule of Maturities of Long-term Debt	Capital Debt Leases Total (in thousands) 2018 $ 5,985 $ 327 2019 14,915 341 2020 1,806 339 2021 4,400 269 2022 450 156 Thereafter 18,168 — $ 45,724 $ 1,432 $ 47,156

Income Taxes (Tables)

Income Taxes (Tables)	12 Months Ended
	Dec. 31, 2017
Income Taxes
Schedule of income (loss) before income taxes	Year Ended December 31, 2017 2016 2015 (in thousands) Income (loss) before income taxes: United States $ 7,266 $ 20,888 $ (4,344) Foreign (5,643) (5,942) (6,020) Total income (loss) before taxes $ 1,623 $ 14,946 $ (10,364)
Summary of provision (benefit) for income taxes	Year Ended December 31, 2017 2016 2015 (in thousands) Current provision (benefit): Federal $ (6,380) $ 7,279 $ 82 State 133 344 73 Foreign 643 787 (112) Total current provision (benefit) (5,604) 8,410 43 Deferred provision (benefit): Federal 5,824 (2,491) (5,222) State (2,140) (1,066) (1,250) Foreign (965) (439) (1,148) Total deferred provision (benefit) 2,719 (3,996) (7,620) Total provision (benefit) for income taxes $ (2,885) $ 4,414 $ (7,577)
Schedule of reconciliation of the statutory federal income tax rate	Year Ended December 31, 2017 2016 2015 Statutory federal income tax (benefit) 35.0 % 35.0 % (35.0) % State tax expense, net of federal tax benefit (80.5) (3.1) (7.4) Foreign tax rate differences 3.0 1.8 (1.1) Foreign valuation allowance 99.4 14.4 (23.3) Qualified production activities deduction 69.0 (8.7) — Research and development credits (192.6) (11.7) (15.4) Share-based compensation (128.0) 3.0 7.7 Executive compensation 13.2 — — Deferred tax remeasurement (1.1) — — Employee-related expenses 4.8 0.4 0.7 Other (0.1) (1.6) 0.7 Effective tax rate (benefit) (177.9) % 29.5 % (73.1) %
Summary of deferred tax assets and liabilities	December 31, 2017 2016 (in thousands) Deferred tax assets: Net operating loss carryforward $ 7,356 $ 4,698 State income taxes 221 393 Inventory capitalization and reserve 5,333 7,368 Accrued payroll and benefits 1,233 1,813 Share-based compensation 6,504 10,545 Research and development credits 21,550 9,668 Alternative minimum tax 656 895 Accrued professional fees 344 1,333 Product return allowance 1,879 1,758 Accrued chargebacks 1,856 15,158 Bad debt reserve 60 95 Intangibles 2,022 3,370 Accrued for workers’ compensation insurance 1,063 1,409 Others 52 — Total deferred tax assets 50,129 58,503 Deferred tax liabilities: Depreciation/amortization 8,821 13,763 Intangibles 6,992 8,208 Federal impact of state deferred taxes 3,025 3,784 Other — 158 Total deferred tax liabilities 18,838 25,913 Valuation allowance (4,907) (3,044) Net deferred tax assets $ 26,384 $ 29,546
Schedule of unrecognized tax benefits	December 31, 2017 2016 2015 (in thousands) Balance at the beginning of the year $ 6,686 $ 5,595 $ 4,783 Additions based on tax positions related to prior years — 188 — Additions based on tax positions related to the current year 1,300 903 812 Deductions based on statute of limitations (548) — — Balance at the end of the year $ 7,438 $ 6,686 $ 5,595

Stockholders' Equity (Tables)

Stockholders' Equity (Tables)	12 Months Ended
	Dec. 31, 2017
Stockholders' Equity
Schedule of key assumptions to determine fair value of options	Year Ended December 31, 2017 2016 2015 Average volatility 37.0 % 30.4 % 27.1 % Risk-free interest rate 2.1 % 1.5 % 1.3 % Weighted-average expected life in years 5.5 5.5 4.5 Dividend yield rate — % — % — %
Schedule of the summary of option activity under all plans	Weighted-Average Weighted-Average Remaining Aggregate Exercise Contractual Intrinsic Options Price Term (Years) Value (1) (in thousands) Outstanding as of December 31, 2016 12,530,297 $ 14.57 Options granted 1,815,813 14.23 Options exercised (2,958,473) 11.80 Options cancelled (46,858) 13.67 Options expired (442,078) 29.96 Outstanding as of December 31, 2017 10,898,701 $ 14.65 4.95 $ 56,370 Exercisable as of December 31, 2017 6,588,460 $ 15.32 3.53 $ 32,185
Schedule of information relating to options grants	Year Ended December 31, 2017 2016 2015 (in thousands, except per share data) Weighted-average grant date fair value per option share $ 4.98 $ 3.42 $ 3.45 Intrinsic value of options exercised 17,247 7,446 3,247 Cash received from options exercised 19,098 20,338 13,502 Total fair value of the options vested during the year 7,263 8,654 6,634
Schedule of the summary of nonvested options status	Weighted-Average Grant Date Options Fair Value Non-vested as of December 31, 2016 4,592,187 $ 3.61 Options granted 1,815,813 4.98 Options vested (2,050,901) 3.54 Options forfeited (46,858) 4.76 Non-vested as of December 31, 2017 4,310,241 4.21
Schedule of information relating to RSU grants and deliveries	Total Fair Market Value of RSUs Issued Total RSUs as Issued Compensation (1) (in thousands) RSUs outstanding at December 31, 2016 1,215,786 RSUs granted 679,024 $ 9,346 RSUs forfeited (16,231) RSUs vested (2) (485,798) RSUs outstanding at December 31, 2017 1,392,781 (1) The total FMV is derived from the number of RSUs granted times the current stock price on the date of grant. (2) Of the vested RSUs, 184,699 shares of common stock were surrendered to fulfil tax withholding obligations
Schedule of recorded share-based compensation expense under all plans	Year Ended December 31, 2017 2016 2015 (in thousands) Cost of revenues $ 3,756 $ 2,967 $ 2,526 Operating expenses: Selling, distribution, and marketing 302 220 192 General and administrative 11,643 10,865 9,185 Research and development 1,386 1,072 912 Total share-based compensation $ 17,087 $ 15,124 $ 12,815

Commitments and Contingencies (

Commitments and Contingencies (Tables)	12 Months Ended
	Dec. 31, 2017
Commitments and Contingencies
Schedule of future minimum rental payments for operating leases	Operating Leases (in thousands) 2018 $ 3,333 2019 2,624 2020 2,321 2021 1,523 2022 740 $ 10,541

Quarterly Financial Data (Una39

Quarterly Financial Data (Unaudited) (Tables)	12 Months Ended
	Dec. 31, 2017
Quarterly Financial Data
Schedule of Quarterly Financial Information	2017 Quarters First Second Third Fourth (in thousands, except per share data) Net revenues Finished pharmaceutical products $ 55,934 $ 63,765 $ 54,455 $ 55,985 API 736 1,422 3,461 4,417 Total net revenues $ 56,670 $ 65,187 $ 57,916 $ 60,402 Gross profit Finished pharmaceutical products $ 24,310 $ 28,866 $ 21,310 $ 22,317 API (1,482) (2,119) (669) (1,738) Total gross profit $ 22,828 $ 26,747 $ 20,641 $ 20,579 Net income $ 893 $ 1,972 $ 175 $ 1,468 Weighted-average shares used to compute net income per share Basic 46,069 46,025 46,101 46,233 Diluted 48,057 47,866 48,215 49,330 Net income per share Basic $ 0.02 $ 0.04 $ 0.00 $ 0.03 Diluted $ 0.02 $ 0.04 $ 0.00 $ 0.03 2016 Quarters First Second Third Fourth (in thousands, except per share data) Net revenue Finished pharmaceutical products $ 58,554 $ 63,756 $ 59,058 $ 58,853 API 812 4,277 5,165 4,690 Total net revenues $ 59,366 $ 68,033 $ 64,223 $ 63,543 Gross profit Finished pharmaceutical products $ 25,824 $ 30,598 $ 28,621 $ 21,057 API (922) 1,116 (1,009) (1,096) Total gross profit $ 24,902 $ 31,714 $ 27,612 $ 19,961 Net income (loss) $ 2,489 $ 6,895 $ 3,890 $ (2,742) Weighted-average shares used to compute net income (loss) per share Basic 45,041 44,957 45,398 46,104 Diluted 46,810 45,968 47,953 46,104 Net income (loss) per share Basic $ 0.06 $ 0.15 $ 0.09 $ (0.06) Diluted $ 0.05 $ 0.15 $ 0.08 $ (0.06)

Summary of Significant Accoun40

Summary of Significant Accounting Policies (Details) - USD ($)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Summary of Significant Accounting Policies
Gains and losses of intercompany foreign currency transactions	$ 4,300,000	$ (1,500,000)	$ (2,000,000)
Income tax expense allocated to other comprehensive income	1,500,000
Shipping and handling costs	3,000,000	2,400,000	2,600,000
Allowance for doubtful accounts	300,000	300,000
Restricted cash	1,900,000
Certificates of deposit	2,300,000	1,400,000
Inventory adjustment to reflect net realizable value	8,500,000	7,300,000
Amount retained, individual claims	350,000
Amount retained, aggregate claims	2,600,000
Actuarially Determined Self-insurance Expense	1,500,000	1,600,000	$ 1,200,000
Self-insurance Claims Liability	$ 4,100,000	$ 3,500,000

Summary of Significant Accoun41

Summary of Significant Accounting Policies (Schedule of PP&E Useful Lives) (Details)	12 Months Ended
	Dec. 31, 2017
Buildings | Minimum
Property, Plant and Equipment
Property, Plant and Equipment Useful Life	20 years
Buildings | Maximum
Property, Plant and Equipment
Property, Plant and Equipment Useful Life	31 years
Machinery and equipment | Minimum
Property, Plant and Equipment
Property, Plant and Equipment Useful Life	2 years
Machinery and equipment | Maximum
Property, Plant and Equipment
Property, Plant and Equipment Useful Life	12 years
Furniture and Fixtures | Minimum
Property, Plant and Equipment
Property, Plant and Equipment Useful Life	3 years
Furniture and Fixtures | Maximum
Property, Plant and Equipment
Property, Plant and Equipment Useful Life	7 years
Automobiles | Minimum
Property, Plant and Equipment
Property, Plant and Equipment Useful Life	4 years
Automobiles | Maximum
Property, Plant and Equipment
Property, Plant and Equipment Useful Life	5 years

Summary of Significant Accoun42

Summary of Significant Accounting Policies (Schedule of Intangible Useful Lives) (Details)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Useful life of intangibles	12 years	12 years
Product rights
Useful life of intangibles	12 years	12 years
Product rights | Minimum
Useful life of intangibles	5 years
Product rights | Maximum
Useful life of intangibles	15 years
Patents
Useful life of intangibles	12 years	10 years
Patents | Minimum
Useful life of intangibles	10 years
Patents | Maximum
Useful life of intangibles	20 years
Land-use rights
Useful life of intangibles	39 years	39 years
Land-use rights | Minimum
Useful life of intangibles	37 years
Land-use rights | Maximum
Useful life of intangibles	50 years

Summary of Significant Accoun43

Summary of Significant Accounting Policies (Schedule of Accounts Payable and Accrued Liabilities) (Details) - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Summary of Significant Accounting Policies
Accrued customer fees and rebates	$ 15,981	$ 6,940
Accrued payroll and related benefits	15,680	13,847
Accrued product returns, current portion	4,133	1,800
Other accrued liabilities	5,132	5,027
Total accrued liabilities	40,926	27,614
Accounts payable	16,629	19,932
Total accounts payable and accrued liabilities	$ 57,555	$ 47,546

Business Acquisitions (Details)

Business Acquisitions (Details) $ in Thousands	1 Months Ended			12 Months Ended
	Aug. 31, 2016USD ($)item	Mar. 31, 2016USD ($)item	Jan. 31, 2016USD ($)	Dec. 31, 2017	Dec. 31, 2016USD ($)
Business Acquisitions
Payment to Acquire Business, Gross					$ 12,461
Useful life of intangibles				12 years	12 years
Goodwill related to acquisition of business					$ 391
International Medication Systems (UK) Limited
Business Acquisitions
Number of Marketing Authorizations Acquired | item	33
Number of Different Injectable Chemical Entities | item	11
Payment to Acquire Business, Gross	$ 7,700
Marketing authorizations acquired	9,200
Manufacturing equipment acquired	100
Deferred tax liability assumed	$ 1,600
Useful life of intangibles	10 years
Hikma Pharmaceuticals PLC
Business Acquisitions
Number of Different Injectable Chemical Entities | item		11
Payment to Acquire Business, Gross		$ 4,000
Useful life of intangibles		15 years
Number of Injectable Products Acquired | item		14
Assets acquired		$ 4,000
Letop
Business Acquisitions
Payment to Acquire Business, Gross			$ 800
Assets acquired			1,400
Purchase price			1,700
Deposit that ANP previously paid which was effectively eliminated upon the consummation of the transaction			900
Liabilities assumed			$ 100

Revenue Recognition (Analysis o

Revenue Recognition (Analysis of the Chargeback Provision) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Beginning balance	$ 39,709	$ 15,888
Provision for chargebacks and rebates	152,011	171,159
Credits and payments issued to third parties	(173,250)	(147,338)
Ending balance	18,470	39,709
Accounts Receivable, Net
Provision for chargebacks and rebates	6,800	37,800
Accounts Payable and Accrued Liabilities
Provision for chargebacks and rebates	$ 11,700	$ 1,900

Revenue Recognition (Analysis46

Revenue Recognition (Analysis of Product Return Liability) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Revenue Recognition
Beginning balance	$ 3,143	$ 2,621
Provision for product returns	5,754	1,753
Credits issued to third parties	(2,375)	(1,231)
Ending balance	6,522	3,143
Sales not recognized in revenues due to insufficient information available to estimate a reasonable product return accrual	$ 1,200	$ 500
Aggregate product return rate	1.30%	1.10%
Return accrual included in other long-term liabilities	$ 2,400	$ 1,300

Income (Loss) per Share (Narrat

Income (Loss) per Share (Narrative) (Details) - $ / shares	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Stock Options
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Shares	839,651	2,379,984	12,240,467
Antidilutive Securities Excluded from Computation of Earnings Per Share, Exercise Price of Excluded Securities	$ 26.43	$ 22.46
Restricted Stock Units (RSUs)
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Shares			866,540
Employee Stock Purchase Plan (ESPP)
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items]
Antidilutive Securities Excluded from Computation of Earnings Per Share, Shares			61,766

Income (Loss) per Share (Calcul

Income (Loss) per Share (Calculation of Basic and Diluted Net Income (Loss) Per Share) (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Basic and dilutive numerator:
Net income (loss)	$ 1,468	$ 175	$ 1,972	$ 893	$ (2,742)	$ 3,890	$ 6,895	$ 2,489	$ 4,508	$ 10,532	$ (2,787)
Denominator:
Shares outstanding									46,107	45,375	44,961
Weighted-average shares outstanding—basic	46,233	46,101	46,025	46,069	46,104	45,398	44,957	45,041	46,107	45,375	44,961
Net effect of dilutive securities:
Incremental shares from equity awards									2,260	2,129
Weighted-average shares outstanding — diluted	49,330	48,215	47,866	48,057	46,104	47,953	45,968	46,810	48,367	47,504	44,961
Net income (loss) per share — basic	$ 0.03	$ 0	$ 0.04	$ 0.02	$ (0.06)	$ 0.09	$ 0.15	$ 0.06	$ 0.10	$ 0.23	$ (0.06)
Net income (loss) per share — diluted	$ 0.03	$ 0	$ 0.04	$ 0.02	$ (0.06)	$ 0.08	$ 0.15	$ 0.05	$ 0.09	$ 0.22	$ (0.06)

Segment Reporting (Selected Fin

Segment Reporting (Selected Financial Information by Reporting Segment) (Details) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2017USD ($)	Sep. 30, 2017USD ($)	Jun. 30, 2017USD ($)	Mar. 31, 2017USD ($)	Dec. 31, 2016USD ($)	Sep. 30, 2016USD ($)	Jun. 30, 2016USD ($)	Mar. 31, 2016USD ($)	Dec. 31, 2017USD ($)segment	Dec. 31, 2016USD ($)	Dec. 31, 2015USD ($)
Segment Reporting Information [Line Items]
Number of Reportable Segments | segment									2
Net revenues:
Net Revenue	$ 60,402	$ 57,916	$ 65,187	$ 56,670	$ 63,543	$ 64,223	$ 68,033	$ 59,366	$ 240,175	$ 255,165	$ 251,519
Gross Profit:
Gross Profit	20,579	20,641	26,747	22,828	19,961	27,612	31,714	24,902	90,795	104,189	77,347
Operating expenses									91,690	88,497	84,245
Income (loss) from operations									(895)	15,692	(6,898)
Non-operating income (expenses)									2,518	(746)	(3,466)
Income (loss) before income taxes									1,623	14,946	(10,364)
Finished Pharmaceutical Products
Net revenues:
Net Revenue	55,985	54,455	63,765	55,934	58,853	59,058	63,756	58,554	230,139	240,221	224,941
Gross Profit:
Gross Profit	22,317	21,310	28,866	24,310	21,057	28,621	30,598	25,824	96,803	106,100	74,146
Epinephrine
Segment Reporting Information [Line Items]
Net revenues recognized									17,800	18,600	7,800
Cost of revenues										3,300
API
Net revenues:
Net Revenue	4,417	3,461	1,422	736	4,690	5,165	4,277	812	10,036	14,944	26,578
Gross Profit:
Gross Profit	$ (1,738)	$ (669)	$ (2,119)	$ (1,482)	$ (1,096)	$ (1,009)	$ 1,116	$ (922)	$ (6,008)	$ (1,911)	$ 3,201

Segment Reporting (Summary of N

Segment Reporting (Summary of Net Revenues by Product Segment) (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Segment Reporting Information, Revenue for Reportable Segment [Abstract]
Net Revenue	$ 60,402	$ 57,916	$ 65,187	$ 56,670	$ 63,543	$ 64,223	$ 68,033	$ 59,366	$ 240,175	$ 255,165	$ 251,519
Finished Pharmaceutical Products
Segment Reporting Information, Revenue for Reportable Segment [Abstract]
Net Revenue	$ 55,985	$ 54,455	$ 63,765	$ 55,934	$ 58,853	$ 59,058	$ 63,756	$ 58,554	230,139	240,221	224,941
Finished Pharmaceutical Products | Enoxaparin
Segment Reporting Information, Revenue for Reportable Segment [Abstract]
Net Revenue									36,593	59,320	84,502
Finished Pharmaceutical Products | Naloxone
Segment Reporting Information, Revenue for Reportable Segment [Abstract]
Net Revenue									42,342	47,532	38,602
Finished Pharmaceutical Products | Lidocaine
Segment Reporting Information, Revenue for Reportable Segment [Abstract]
Net Revenue									37,602	36,600	30,260
Finished Pharmaceutical Products | Phytonadione
Segment Reporting Information, Revenue for Reportable Segment [Abstract]
Net Revenue									37,946	33,315	19,804
Finished Pharmaceutical Products | Epinephrine
Segment Reporting Information, Revenue for Reportable Segment [Abstract]
Net Revenue									25,914	25,661	14,936
Finished Pharmaceutical Products | Other Finished Pharmaceutical Products
Segment Reporting Information, Revenue for Reportable Segment [Abstract]
Net Revenue									$ 49,742	$ 37,793	$ 36,837

Segment Reporting (Summary of R

Segment Reporting (Summary of Revenues and Long-Lived Assets by Geographic Region) (Details) - USD ($) $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Revenues from External Customers and Long-Lived Assets [Line Items]
Net Revenue	$ 60,402	$ 57,916	$ 65,187	$ 56,670	$ 63,543	$ 64,223	$ 68,033	$ 59,366	$ 240,175	$ 255,165	$ 251,519
Long-Lived Assets	185,339				152,944				185,339	152,944
UNITED STATES
Revenues from External Customers and Long-Lived Assets [Line Items]
Net Revenue									234,321	249,007	243,295
Long-Lived Assets	110,235				104,110				110,235	104,110
CHINA
Revenues from External Customers and Long-Lived Assets [Line Items]
Long-Lived Assets	41,078				35,085				41,078	35,085
FRANCE
Revenues from External Customers and Long-Lived Assets [Line Items]
Net Revenue									5,854	6,158	$ 8,224
Long-Lived Assets	$ 34,026				13,659				$ 34,026	13,659
UNITED KINGDOM
Revenues from External Customers and Long-Lived Assets [Line Items]
Long-Lived Assets					$ 90					$ 90

Customer and Supplier Concent52

Customer and Supplier Concentration (Details) - Customer Concentration Risk [Member]	12 Months Ended
	Dec. 31, 2017customeritem	Dec. 31, 2016customeritem	Dec. 31, 2015item
Revenue, Major Customer [Line Items]
Number of major customers that are wholesale distributors	3
Accounts Receivable, Net
Revenue, Major Customer [Line Items]
Number of major customers | customer	4	4
Net Revenues
Revenue, Major Customer [Line Items]
Number of major customers	4	4	4
Actavis, Inc. | Accounts Receivable, Net
Revenue, Major Customer [Line Items]
Major Customers		1.00%
Actavis, Inc. | Net Revenues
Revenue, Major Customer [Line Items]
Major Customers		14.00%	21.00%
AmerisourceBergen | Accounts Receivable, Net
Revenue, Major Customer [Line Items]
Major Customers	33.00%	30.00%
AmerisourceBergen | Net Revenues
Revenue, Major Customer [Line Items]
Major Customers	28.00%	21.00%	17.00%
Cardinal Health | Accounts Receivable, Net
Revenue, Major Customer [Line Items]
Major Customers	12.00%	28.00%
Cardinal Health | Net Revenues
Revenue, Major Customer [Line Items]
Major Customers	23.00%	22.00%	17.00%
McKesson | Accounts Receivable, Net
Revenue, Major Customer [Line Items]
Major Customers	22.00%	19.00%
McKesson | Net Revenues
Revenue, Major Customer [Line Items]
Major Customers	27.00%	21.00%	22.00%

Goodwill and Intangible Asset53

Goodwill and Intangible Assets (Summary of Intangible Assets) (Details) $ in Thousands	1 Months Ended					3 Months Ended	12 Months Ended
	Jan. 31, 2018USD ($)	Feb. 28, 2017USD ($)item	Aug. 31, 2016USD ($)item	Mar. 31, 2016USD ($)item	Jan. 31, 2016USD ($)	Jun. 30, 2017USD ($)	Dec. 31, 2017USD ($)	Dec. 31, 2016USD ($)	Dec. 31, 2015USD ($)
Definite-lived intangible assets
Weighted-Average Life (Years)							12 years	12 years
Finite-Lived Intangible Assets, Gross							$ 39,669	$ 43,173
Accumulated Amortization							28,215	26,067
Finite-Lived Intangible Assets, Net							11,454	17,106
Indefinite-lived intangible assets
Goodwill recognized							4,461	3,976	$ 3,726
Subtotal, Original Cost							33,686	33,201
Subtotal, Net Book Value							33,686	33,201
Balance, Original Cost							73,355	76,374
Balance, Net Book Value							45,140	50,307
Payment to Acquire Business, Gross								12,461
Proceeds received from sale of ANDAs							2,000
Hikma Pharmaceuticals PLC
Indefinite-lived intangible assets
Proceeds received from sale of ANDAs		$ 1,000				$ 1,000
Royalty Fee Percentage		2.00%
Indemnification Liability Payable		$ 600
Gain recognized within operating (income) expenses							2,600
Hikma Pharmaceuticals PLC | Subsequent Event
Indefinite-lived intangible assets
Proceeds received from sale of ANDAs	$ 4,400
Finished Pharmaceutical Products
Indefinite-lived intangible assets
Goodwill recognized							4,461	3,976
Trademarks
Indefinite-lived intangible assets
Indefinite-lived intangible assets							$ 29,225	$ 29,225
Product rights
Definite-lived intangible assets
Weighted-Average Life (Years)							12 years	12 years
Finite-Lived Intangible Assets, Gross							$ 27,134	$ 27,134
Accumulated Amortization							26,243	24,461
Finite-Lived Intangible Assets, Net							$ 891	$ 2,673
Patents
Definite-lived intangible assets
Weighted-Average Life (Years)							12 years	10 years
Finite-Lived Intangible Assets, Gross							$ 486	$ 293
Accumulated Amortization							170	137
Finite-Lived Intangible Assets, Net							$ 316	$ 156
Land-use rights
Definite-lived intangible assets
Weighted-Average Life (Years)							39 years	39 years
Finite-Lived Intangible Assets, Gross							$ 2,540	$ 2,540
Accumulated Amortization							419	354
Finite-Lived Intangible Assets, Net							$ 2,121	$ 2,186
Other intangible assets
Definite-lived intangible assets
Weighted-Average Life (Years)							4 years	1 year
Finite-Lived Intangible Assets, Gross							$ 69	$ 574
Accumulated Amortization							46	534
Finite-Lived Intangible Assets, Net							$ 23	$ 40
International Medication Systems (UK) Limited
Definite-lived intangible assets
Weighted-Average Life (Years)			10 years
Indefinite-lived intangible assets
Payment to Acquire Business, Gross			$ 7,700
Marketing authorizations acquired			$ 9,200
Number of Different Injectable Chemical Entities | item			11
International Medication Systems (UK) Limited | Acquired international product rights
Definite-lived intangible assets
Weighted-Average Life (Years)							10 years	10 years
Finite-Lived Intangible Assets, Gross							$ 9,440	$ 8,632
Accumulated Amortization							1,337	359
Finite-Lived Intangible Assets, Net							$ 8,103	$ 8,273
Hikma Pharmaceuticals PLC
Definite-lived intangible assets
Weighted-Average Life (Years)				15 years
Indefinite-lived intangible assets
Payment to Acquire Business, Gross				$ 4,000
Number of Injectable Products Acquired | item				14
Number of Different Injectable Chemical Entities | item				11
Number of Injectable Products Sold | item		14
Sale price of intangible assets		$ 6,400
Hikma Pharmaceuticals PLC | Acquired ANDAs
Definite-lived intangible assets
Weighted-Average Life (Years)								15 years
Finite-Lived Intangible Assets, Gross								$ 4,000
Accumulated Amortization								222
Finite-Lived Intangible Assets, Net								$ 3,778
Letop
Indefinite-lived intangible assets
Payment to Acquire Business, Gross					$ 800

Goodwill and Intangible Asset54

Goodwill and Intangible Assets (Summary of Changes in the Carrying Amount of Goodwill) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Goodwill and Intangible Assets
Beginning balance	$ 3,976	$ 3,726
Goodwill related to acquisition of business		391
Currency translation and other adjustments	485	(141)
Ending balance	$ 4,461	$ 3,976

Goodwill and Intangible Asset55

Goodwill and Intangible Assets (Summary of Expected Amortization Expense) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
2,018	$ 1,772
2,019	870
2,020	864
2,021	864
2,022	844
Thereafter	6,240
Finite-Lived Intangible Assets, Net	11,454	$ 17,106
Indefinite-lived intangibles	33,686
Balance, Net Book Value	45,140	50,307
Amortization expense related to Cortrosyn	2,856	2,517	$ 1,938
Product rights
Finite-Lived Intangible Assets, Net	891	2,673
Amortization expense related to Cortrosyn	$ 2,700	$ 2,400	$ 1,800

Inventories (Details)

Inventories (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Raw materials and supplies	$ 19,973	$ 36,209
Work in process	22,469	22,266
Finished goods	21,167	21,279
Total inventory, net	63,609	79,754
Inventory adjustment to reflect net realizable value	8,500	7,300
Enoxaparin
Inventory adjustment to reflect net realizable value	$ 5,500	3,100
Injection USP Vial Inventory
Inventory adjustment to reflect net realizable value		$ 3,300

Property, Plant, and Equipmen57

Property, Plant, and Equipment (Summary of Property, Plant, and Equipment) (Details) - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Property, Plant and Equipment [Line Items]
Total property, plant, and equipment	$ 318,667	$ 274,957
Less accumulated depreciation and amortization	(133,328)	(122,013)
Total property, plant, and equipment, net	185,339	152,944
Buildings
Property, Plant and Equipment [Line Items]
Total property, plant, and equipment	89,124	85,283
Leasehold improvement
Property, Plant and Equipment [Line Items]
Total property, plant, and equipment	29,847	24,619
Land
Property, Plant and Equipment [Line Items]
Total property, plant, and equipment	7,110	6,857
Machinery and equipment
Property, Plant and Equipment [Line Items]
Total property, plant, and equipment	118,056	111,041
Furniture, fixtures, and automobiles
Property, Plant and Equipment [Line Items]
Total property, plant, and equipment	16,385	15,113
Construction in progress
Property, Plant and Equipment [Line Items]
Total property, plant, and equipment	58,145	32,044
Equipment | Primatene Mist
Property, Plant and Equipment [Line Items]
Total property, plant, and equipment	$ 2,300	$ 2,600

Property, Plant, and Equipmen58

Property, Plant, and Equipment (Narrative) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Property, Plant and Equipment [Line Items]
Interest Costs Capitalized	$ 1,100	$ 800	$ 1,100
Capitalized manufacturing equipment for specific use	318,667	274,957
Accounts Payable and Accrued Liabilities
Property, Plant and Equipment [Line Items]
Purchase of property, plant, and equipment included in accounts payable and accrued liabilities	$ 6,700	$ 2,900

Debt (Schedule of Debt) (Detail

Debt (Schedule of Debt) (Details) $ in Thousands, € in Millions	Dec. 31, 2017EUR (€)	Dec. 31, 2017USD ($)	Dec. 31, 2016USD ($)
Debt Instrument
Equipment under Capital Leases		$ 1,357	$ 1,614
Total debt and capital leases		47,156	37,722
Less current portion of long-term debt and capital leases		6,312	5,366
Long-term debt and capital leases, net of current portion		40,844	32,356
Equipment Loan - Due April 2017 | East West Bank
Debt Instrument
Long Term Debt			433
Equipment Loan - Due January 2019 | East West Bank
Debt Instrument
Long Term Debt		1,668	3,208
Mortgage Payable - Due February 2021 | East West Bank
Debt Instrument
Long Term Debt		3,577	3,660
Equipment Loan - Due June 2021 | East West Bank
Debt Instrument
Long Term Debt		4,286	2,882
Mortgage Payable - Due October 2026 | East West Bank
Debt Instrument
Long Term Debt		3,524	3,582
Mortgage Payable - Due June 2027 | East West Bank
Debt Instrument
Long Term Debt		8,936
Acquisition Loan - Due April 2019 | Cathay Bank
Debt Instrument
Long Term Debt		15,073	17,079
Mortgage Payable - Due August 2027 | Cathay Bank
Debt Instrument
Long Term Debt		7,795	4,367
French Government Loan - Due March 2018 | Seine-Normandie Water Agency
Debt Instrument
Long Term Debt		17	30
French Government Loan - Due June 2020 | Seine-Normandie Water Agency
Debt Instrument
Long Term Debt		85	99
French Government Loan - Due July 2021 | Seine-Normandie Water Agency
Debt Instrument
Long Term Debt		239	262
Note Payable To Merck
Debt Instrument
Long Term Debt	€ 0.5	$ 599	$ 506

Debt (Narrative) (Details)

Debt (Narrative) (Details) € in Millions

Aug. 14, 2017USD ($)

Jun. 28, 2017USD ($)

May 18, 2017USD ($)building

May 11, 2017USD ($)

Sep. 08, 2016USD ($)building

Jan. 31, 2015USD ($)

Jan. 05, 2015USD ($)

Apr. 30, 2014EUR (€)

Apr. 22, 2014USD ($)

Mar. 15, 2013USD ($)

Jan. 31, 2015EUR (€)item

Dec. 31, 2016USD ($)

Dec. 31, 2017EUR (€)

Dec. 31, 2017USD ($)

Mar. 31, 2016USD ($)

Jan. 08, 2016USD ($)building

Jan. 31, 2015USD ($)item

Apr. 30, 2014USD ($)

Apr. 09, 2014USD ($)

Jul. 05, 2013USD ($)

Mar. 31, 2013

Apr. 10, 2012USD ($)

Mar. 31, 2012USD ($)

Mar. 05, 2012USD ($)

Sep. 15, 2006USD ($)

Debt

Long-term Debt and Capital Lease Obligations

$ 32,356,000

$ 40,844,000

Payment to Acquire Business, Gross

12,461,000

Capital Leased Assets, Gross

2,000,000

1,600,000

Equipment Loan - Due April 2017 | East West Bank

Debt

Principal amount

$ 4,900,000

Line of Credit Facility, Maximum Borrowing Capacity

$ 8,000,000

Long Term Debt

433,000

Equipment Loan - Due April 2017 | East West Bank | Prime Rate

Debt

Debt Instrument, Basis Spread on Variable Rate

0.25%

Line of Credit Facility - Due December 2018 | East West Bank

Debt

Line of Credit Facility, Maximum Borrowing Capacity

$ 15,000,000

$ 10,000,000

Line of Credit outstanding

0

Equipment Loan - Due January 2019 | East West Bank

Debt

Principal amount

$ 6,200,000

Debt Instrument, Interest Rate, Stated Percentage

4.48%

Line of Credit Facility, Maximum Borrowing Capacity

$ 8,000,000

Proceeds from borrowing under lines of credit

$ 6,200,000

Long Term Debt

3,208,000

1,668,000

Mortgage Payable - Due February 2021 | East West Bank

Debt

Principal amount

$ 3,700,000

Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid

$ 3,300,000

Debt Instrument, Interest Rate, Stated Percentage

4.39%

Long Term Debt

3,660,000

3,577,000

Mortgage Payable - Due February 2021 | East West Bank | Rancho Cucamonga, California

Debt

Number of Buildings Securing Loan | building

1

Equipment Loan - Due June 2021 | East West Bank

Debt

Line of Credit Converted into Equipment Loan, Amount

$ 5,000,000

Debt Instrument, Interest Rate, Stated Percentage

4.86%

Line of Credit Facility, Maximum Borrowing Capacity

$ 5,000,000

Long Term Debt

2,882,000

4,286,000

Equipment Line of Credit - Due December 2022 | East West Bank

Debt

Line of Credit Facility, Maximum Borrowing Capacity

$ 8,000,000

Line of Credit outstanding

0

Draw down period

18 months

Term of loan after draw down period expires

48 months

Mortgage Payable - Due October 2026 | East West Bank

Debt

Long Term Debt

3,582,000

3,524,000

Mortgage Payable - Due October 2026 | East West Bank | Rancho Cucamonga, California

Debt

Principal amount

$ 3,600,000

$ 2,800,000

Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid

$ 2,900,000

Number of Buildings Securing Loan | building

1

Debt Instrument, Interest Rate, Stated Percentage

4.15%

Mortgage Payable - Due October 2026 | East West Bank | LIBOR | Rancho Cucamonga, California

Debt

Debt Instrument, Basis Spread on Variable Rate

2.75%

Mortgage Payable - Due June 2027 | East West Bank

Debt

Principal amount

$ 9,000,000

Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid

$ 7,400,000

Debt Instrument, Interest Rate, Stated Percentage

4.79%

Interest rate swap, fair value

100,000

Long Term Debt

8,936,000

Mortgage Payable - Due June 2027 | East West Bank | Rancho Cucamonga, California

Debt

Number of Buildings Securing Loan | building

1

Mortgage Payable - Due June 2027 | East West Bank | Chino, California

Debt

Number of Buildings Securing Loan | building

2

Mortgage Payable - Due June 2027 | East West Bank | LIBOR

Debt

Debt Instrument, Basis Spread on Variable Rate

2.50%

Line of Credit Facility - Due May 2018 | Cathay Bank

Debt

Line of Credit Facility, Maximum Borrowing Capacity

$ 20,000,000

Line of Credit outstanding

0

Acquisition Loan - Due April 2019 | Cathay Bank

Debt

Principal amount

$ 21,900,000

Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid

$ 12,000,000

Debt Instrument Loan Collateral Percentage

65.00%

Debt Instrument Covenant Period To Discharge Final Judgment

30 days

Long Term Debt

17,079,000

15,073,000

Mortgage Payable - Due August 2027 | Cathay Bank

Debt

Principal amount

$ 4,600,000

Debt Instrument, Periodic Payment Terms, Balloon Payment to be Paid

$ 3,900,000

Debt Instrument, Interest Rate, Stated Percentage

5.42%

Long Term Debt

4,367,000

7,795,000

Mortgage Payable - Due August 2027 | Cathay Bank | Canton, Massachusetts

Debt

Principal amount

$ 7,900,000

Debt Instrument, Interest Rate, Stated Percentage

4.70%

Duration by which the loan bears interest at fixed rate

5 years

French Government Loans | Seine-Normandie Water Agency

Debt

Principal amount

€ 0.6

$ 700,000

Number of Loans with Government Agency | item

3

3

Debt Instrument, Periodic Payment, Interest

$ 0

Notes Payable

€ 0.3

300,000

Note Payable To Merck

Debt

Principal amount

€ 11.6

$ 16,000,000

Debt Instrument, Term

4 years

Long Term Debt

$ 506,000

€ 0.5

$ 599,000

Minimum | Equipment Loan - Due April 2017 | East West Bank

Debt

Debt Instrument, Interest Rate, Stated Percentage

3.50%

Minimum | Line of Credit Facility - Due May 2018 | Cathay Bank | Prime Rate

Debt

Debt Instrument, Interest Rate, Stated Percentage

4.00%

Minimum | Acquisition Loan - Due April 2019 | Cathay Bank | Prime Rate

Debt

Debt Instrument, Basis Spread on Variable Rate

4.00%

Minimum | French Government Loans | Seine-Normandie Water Agency

Debt

Debt Instrument, Term

3 years

Minimum | French Government Loans | Seine-Normandie Water Agency | Prime Rate

Debt

Debt Instrument, Interest Rate, Stated Percentage

4.00%

4.00%

Minimum | Note Payable To Merck

Debt

Debt Instrument, Interest Rate, Stated Percentage

3.00%

3.00%

Minimum | Note Payable To Merck | Prime Rate

Debt

Debt Instrument, Interest Rate, Stated Percentage

4.00%

4.00%

Maximum | French Government Loans | Seine-Normandie Water Agency

Debt

Debt Instrument, Term

6 years

Debt (Long-Term Debt Maturities

Debt (Long-Term Debt Maturities) (Details) - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016
Debt
2,018	$ 5,985
2,019	14,915
2,020	1,806
2,021	4,400
2,022	450
Thereafter	18,168
Total long-term Debt	45,724
Capital Leases
2,018	327
2,019	341
2,020	339
2,021	269
2,022	156
Capital Leases, Future Minimum Payments, Present Value of Net Minimum Payments, Total	1,432
Total debt and capital leases	$ 47,156	$ 37,722

Income Taxes (Narrative) (Detai

Income Taxes (Narrative) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2018	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Tax Credit Carryforward [Line Items]
Federal income tax rate		35.00%	35.00%	35.00%
Cumulative excess benefits of stock compensation established		$ 6,504	$ 10,545
Deferred Tax Assets, Valuation Allowance		4,907	3,044	$ 900
Accumulated undistributed foreign earnings		15,900	$ 14,900
Federal | Research and Development Tax Credit
Tax Credit Carryforward [Line Items]
Tax Credit Carryforward, Amount		$ 10,600
Tax Credit Carryforward, Expiration Date		Dec. 31, 2032
Federal | Alternative Minimum Tax
Tax Credit Carryforward [Line Items]
Tax Credit Carryforward, Amount		$ 500
California | Earliest Tax Year
Tax Credit Carryforward [Line Items]
Operating Loss Carryforwards, Expiration Date		Dec. 31, 2030
California | Research and Development Tax Credit
Tax Credit Carryforward [Line Items]
Tax Credit Carryforward, Amount		$ 16,200
State and Local Jurisdiction
Tax Credit Carryforward [Line Items]
Operating Loss Carryforwards		$ 800
State and Local Jurisdiction | Earliest Tax Year
Tax Credit Carryforward [Line Items]
Operating Loss Carryforwards, Expiration Date		Dec. 31, 2034
State and Local Jurisdiction | California
Tax Credit Carryforward [Line Items]
Operating Loss Carryforwards		$ 17,200
Foreign Tax Authority [Member]
Tax Credit Carryforward [Line Items]
Operating Loss Carryforwards		20,600
Accounting Standards Update 2016-09 [Member]
Tax Credit Carryforward [Line Items]
Cumulative excess benefits of stock compensation established		$ 900
Forecast
Tax Credit Carryforward [Line Items]
Federal income tax rate	21.00%

Income Taxes (Summary of Income

Income Taxes (Summary of Income Before Taxes) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Income (loss) before income taxes:
United States	$ 7,266	$ 20,888	$ (4,344)
Foreign	(5,643)	(5,942)	(6,020)
Income (loss) before income taxes	$ 1,623	$ 14,946	$ (10,364)

Income Taxes (Summary of Provis

Income Taxes (Summary of Provision (Benefit) for Income Taxes) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Current provision (benefit):
Federal	$ (6,380)	$ 7,279	$ 82
State	133	344	73
Foreign	643	787	(112)
Total current provision (benefit)	(5,604)	8,410	43
Deferred provision (benefit):
Federal	5,824	(2,491)	(5,222)
State	(2,140)	(1,066)	(1,250)
Foreign	(965)	(439)	(1,148)
Total deferred provision (benefit)	2,719	(3,996)	(7,620)
Total provision (benefit) for income taxes	$ (2,885)	$ 4,414	$ (7,577)

Income Taxes (Reconciliation of

Income Taxes (Reconciliation of the Statutory Federal Income Tax Rate to the Effective Tax Rate) (Details)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Reconciliation of the statutory federal income tax rate to the Companys effective rate:
Statutory federal income tax (benefit)	35.00%	35.00%	35.00%
State tax expense, net of federal tax benefit	(80.50%)	(3.10%)	(7.40%)
Foreign tax rate differences	3.00%	1.80%	(1.10%)
Foreign valuation allowance	99.40%	14.40%	(23.30%)
Qualified production activities deduction	69.00%	8.70%
Research and development credits	(192.60%)	(11.70%)	(15.40%)
Share-based compensation	(128.00%)	3.00%	7.70%
Executive compensation	13.20%
Deferred tax remeasurement	(1.10%)
Employee-related expenses	4.80%	0.40%	0.70%
Other	(0.10%)	(1.60%)	0.70%
Effective tax rate (benefit)	(177.90%)	29.50%	(73.10%)

Income Taxes (Schedule of Defer

Income Taxes (Schedule of Deferred Tax Assets/Liabilities) (Details) - USD ($) $ in Thousands	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Deferred tax assets:
Net operating loss carryforward	$ 7,356	$ 4,698
State income taxes	221	393
Inventory capitalization and reserve	5,333	7,368
Accrued payroll and benefits	1,233	1,813
Share-based compensation	6,504	10,545
Research and development credits	21,550	9,668
Alternative minimum tax	656	895
Accrued professional fees	344	1,333
Product return allowance	1,879	1,758
Accrued chargebacks	1,856	15,158
Bad debt reserve	60	95
Intangibles	2,022	3,370
Accrued for workers’ compensation insurance	1,063	1,409
Other	52
Total deferred tax assets	50,129	58,503
Deferred tax liabilities:
Depreciation/amortization	8,821	13,763
Intangibles	6,992	8,208
Federal impact of state deferred taxes	3,025	3,784
Other		158
Total deferred tax liabilities	18,838	25,913
Valuation allowance	(4,907)	(3,044)	$ (900)
Net deferred tax assets	$ 26,384	$ 29,546

Income Taxes (Reconciliation 67

Income Taxes (Reconciliation of Unrecognized Tax Benefits) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Reconciliation of Unrecognized Tax Benefits, Excluding Amounts Pertaining to Examined Tax Returns [Roll Forward]
Balance at the beginning of the year	$ 6,686	$ 5,595	$ 4,783
Additions based on tax positions related to prior years		188
Additions based on tax positions related to the current year	1,300	903	812
Deductions based on statute of limitations	(548)
Balance at the end of the year	$ 7,438	$ 6,686	$ 5,595

Income Taxes (Uncertain Income

Income Taxes (Uncertain Income Tax Positions - Narrative) (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016
Income Tax Contingency [Line Items]
Unrecognized Tax Benefits that Would Impact Effective Tax Rate	$ 6.4
Unrecognized Tax Benefits, Decrease Resulting from Prior Period Tax Positions	1.9
Unrecognized Tax Benefits, Income Tax Penalties and Interest Accrued	$ 0.1	$ 0.3
Tax Year 2007 | California
Income Tax Contingency [Line Items]
Income Tax Examination, Year under Examination	2,007
Tax Year 2008 | California
Income Tax Contingency [Line Items]
Income Tax Examination, Year under Examination	2,008
Tax Year 2009 | California
Income Tax Contingency [Line Items]
Income Tax Examination, Year under Examination	2,009
Domestic Tax Authority | Tax Year 2013
Income Tax Contingency [Line Items]
Open Tax Year	2,014
Domestic Tax Authority | Tax Year 2014
Income Tax Contingency [Line Items]
Open Tax Year	2,015
Domestic Tax Authority | Tax Year 2015
Income Tax Contingency [Line Items]
Open Tax Year	2,016
State and Local Jurisdiction | Earliest Tax Year
Income Tax Contingency [Line Items]
Open Tax Year	2,007
State and Local Jurisdiction | Latest Tax Year
Income Tax Contingency [Line Items]
Open Tax Year	2,016

Stockholders' Equity (Common an

Stockholders' Equity (Common and Preferred Stock) (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Stockholders' Equity
Allocated Share-based Compensation Expense	$ 17,087	$ 15,124	$ 12,815
Common stock; shares authorized	300,000,000	300,000,000
Common stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares authorized	20,000,000	20,000,000
Preferred stock, par value (in dollars per share)	$ 0.0001	$ 0.0001
Preferred stock, shares issued	0	0
Preferred stock, shares outstanding	0	0

Stockholders' Equity (2014 Empl

Stockholders' Equity (2014 Employee Stock Purchase Plan) (Details) - USD ($) $ in Thousands	1 Months Ended	12 Months Ended
	Jun. 30, 2014	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share based compensation		$ 17,087	$ 15,124	$ 12,815
2014 Employee Stock Purchase Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Employee Stock Purchase Plan, Offering Duration, Maximum	27 months
Share-based Compensation Arrangement by Share-based Payment Award, Discount from Market Price, Offering Date	85.00%
Stock Issued During Period, Shares, Employee Stock Purchase Plans (in Shares)		374,227
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in Shares)		1,625,773
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized (in Shares)	2,000,000
Allocated share based compensation		$ 600	$ 500	$ 400

Stockholders' Equity (Share Buy

Stockholders' Equity (Share Buyback Program) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015	Aug. 07, 2017	Nov. 07, 2016	Nov. 10, 2015	Nov. 06, 2014
Equity, Class of Treasury Stock [Line Items]
Stock buyback program, authorized amount							$ 10,000
Treasury Stock, Value, Acquired, Cost Method	$ 30,747	$ 9,908	$ 9,865
November 2014 Share Repurchase Plan
Equity, Class of Treasury Stock [Line Items]
Increase authorized for share buyback program				$ 20,000	$ 20,000	$ 10,000
Treasury Stock, Shares, Acquired (in Shares)	1,905,653	759,067	735,679
Treasury Stock, Value, Acquired, Cost Method	$ 30,700	$ 9,900	$ 9,900

Stockholders' Equity (The 2015

Stockholders' Equity (The 2015 Equity Incentive Plan) (Details) - shares	1 Months Ended	12 Months Ended
	Jan. 31, 2018	Dec. 31, 2017	Mar. 18, 2015
The 2015 Equity Incentive Plan
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Available for Grant (in Shares)		4,626,894	5,300,296
Share-based Compensation Arrangement by Share-based Payment Award, Number of Shares Authorized (in Shares)			5,000,000
Equity Incentive Plan, Term		10 years
Share Based Compensation Arrangement By Share Based Payment Award Potential Number of Additional Shares Authorized (in Shares)		3,000,000
Share Based Compensation Arrangement by Share Based Payment Award Potential Annual Increase in Shares, Percentage		2.50%
The 2015 Equity Incentive Plan | Subsequent Event
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Number of Additional Shares Authorized	1,165,590
Amended and Restated 2005 Equity Plan [Member] | Existing Employees | Minimum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period		3 years
Amended and Restated 2005 Equity Plan [Member] | Existing Employees | Maximum
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period		5 years
Amended and Restated 2005 Equity Plan [Member] | New Employees
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period		4 years

Stockholders' Equity (Key Assum

Stockholders' Equity (Key Assumptions Used in Determining Fair Value of Options Granted) (Details)	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Stockholders' Equity
Average overall forfeiture rate	7.00%	7.00%	8.00%
Average volatility	37.00%	30.40%	27.10%
Risk-free interest rate	2.10%	1.50%	1.30%
Weighted-average expected life in years	5 years 6 months	5 years 6 months	4 years 6 months

Stockholders' Equity (Summary o

Stockholders' Equity (Summary of Option Activity) (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Options
Outstanding Options, Beginning of period	12,530,297
Options granted	1,815,813
Options exercised	(2,958,473)
Options cancelled	(46,858)
Options expired	(442,078)
Outstanding Options, End of period	10,898,701	12,530,297
Exercisable at the end of period	6,588,460
Weighted-Average Exercise Price
Outstanding Exercise Price (in dollars per share)	$ 14.57
Options granted (in dollars per share)	14.23
Options exercised (in dollars per share)	11.80
Options cancelled (in dollars per share)	13.67
Options expired (in dollars per share)	29.96
Outstanding Exercise Price (in dollars per share)	14.65	$ 14.57
Exercisable at the end of period (in dollars per share)	$ 15.32
Additional Disclosures
Outstanding Contractual Term (in Years)	4 years 11 months 12 days
Outstanding Intrinsic Value	$ 56,370
Exercisable at the end of period (in Years)	3 years 6 months 11 days
Exercisable aggregate intrinsic value	$ 32,185
Allocated share based compensation	$ 17,087	$ 15,124	$ 12,815
The 2015 Plan and 2005 Plan [Member] | Minimum
Additional Disclosures
Outstanding Contractual Term (in Years)	5 years
Vesting term	3 years
The 2015 Plan and 2005 Plan [Member] | Maximum
Additional Disclosures
Outstanding Contractual Term (in Years)	10 years
Vesting term	5 years
Employee Stock Option
Additional Disclosures
Allocated share based compensation	$ 7,700	8,000	7,900
Employee Stock Option | Board of Directors
Additional Disclosures
Allocated share based compensation	$ 600	$ 700	$ 500

Stockholders' Equity (Informati

Stockholders' Equity (Information Relating to Option Grants and Exercises) (Details) - USD ($) $ / shares in Units, $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Stockholders' Equity
Weighted-average grant date fair value (in Dollars per share)	$ 4.98	$ 3.42	$ 3.45
Intrinsic value of options exercised	$ 17,247	$ 7,446	$ 3,247
Cash received	19,098	20,338	13,502
Total fair value of the options vested during the year	$ 7,263	$ 8,654	$ 6,634

Stockholders' Equity (Summary76

Stockholders' Equity (Summary of Nonvested Options) (Details) - USD ($) $ / shares in Units, $ in Millions	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Options
Nonvested at beginning of period	4,592,187
Options granted	1,815,813
Options vested	(2,050,901)
Options forfeited	(46,858)
Nonvested at end of period	4,310,241	4,592,187
Weighted-Average Grant Date Fair Value
Nonvested at beginning of period (in dollars per share)	$ 3.61
Options granted (in dollars per share)	4.98	$ 3.42	$ 3.45
Options vested (in dollars per share)	3.54
Options forfeited (in dollars per share)	4.76
Nonvested at end of period (in dollars per share)	$ 4.21	$ 3.61
Employee Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Stock Options	$ 11.1
Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition	2 years 1 month 6 days

Stockholders' Equity (Restricte

Stockholders' Equity (Restricted Stock Units) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Outstanding Contractual Term (in Years)	4 years 11 months 12 days
Allocated share based compensation	$ 17,087	$ 15,124	$ 12,815
Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition	2 years 1 month 6 days
Restricted Stock Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period	5 years
Allocated share based compensation	$ 7,100	5,200	3,400
Share-based Compensation, Nonvested Awards, Compensation Cost Not yet Recognized, Period for Recognition	2 years 3 months 18 days
Share-based Compensation Arrangement by Share-based Payment Award, Restricted Stock Units, Number of Shares of Common Stock Per Award (in Shares)	1
Service Share-based Compensation, Nonvested Awards, Compensation Not yet Recognized, Share-based Awards Other than Options	$ 12,300
Maximum | Amended and Restated 2005 Equity Plan [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Share-based Compensation Arrangement by Share-based Payment Award, Expiration Period	10 years
Board of Directors | Restricted Stock Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share based compensation	$ 600	$ 700	$ 500

Stockholders' Equity (Informa78

Stockholders' Equity (Information Relating to RSU Grants and Deliveries) (Details) $ in Thousands	12 Months Ended
	Dec. 31, 2017USD ($)shares
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Total RSUs outstanding at the beginning of the period	1,215,786
RSUs granted	679,024
RSUs forfeited	(16,231)
Total RSUs outstanding at the end of the period	1,392,781
Stock surrendered to fulfill tax withholding obligations	485,798
Total Fair Market Value of RSUs Issued
RSUs granted (in Dollars) | $	$ 9,346
Restricted Stock Units (RSUs)
Share-based Compensation Arrangement by Share-based Payment Award, Equity Instruments Other than Options, Nonvested, Number of Shares [Roll Forward]
Stock surrendered to fulfill tax withholding obligations	184,699

Stockholders' Equity (Equity Aw

Stockholders' Equity (Equity Awards to Consultants and Advisory Board Members) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share based compensation	$ 17,087	$ 15,124	$ 12,815
Consultants and Advisory Board [Member]
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share based compensation	$ 500	$ 100	$ 200

Stockholders' Equity (Share-Bas

Stockholders' Equity (Share-Based Compensation Expense Included in the Statement of Operations) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share based compensation	$ 17,087	$ 15,124	$ 12,815
Cost of revenues
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share based compensation	3,756	2,967	2,526
Selling, distribution and marketing
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share based compensation	302	220	192
General and administrative
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share based compensation	11,643	10,865	9,185
Research and development
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]
Allocated share based compensation	$ 1,386	$ 1,072	$ 912

Employee Benefits (Details)

Employee Benefits (Details) - USD ($) $ in Millions	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Employee Benefits
Defined Contribution Plan, Employer Matching Contribution, Percent of Match	50.00%
Defined Contribution Plan, Employer Matching Contribution, Percent of Employees' Gross Pay	6.00%
Defined Contribution Plan, Employer Contribution Vesting Period	4 years
Defined Contribution Plan, Employer Discretionary Contribution Amount	$ 1.1	$ 1	$ 0.7
Defined Benefit Plan, Assumptions Used Calculating Benefit Obligation, Discount Rate	1.60%	1.75%
Defined Benefit Plan, Benefit Obligation	$ 2.1	$ 1.7
Pension Expense	$ 0.2	$ 0.2	$ 0.1

Commitments and Contingencies82

Commitments and Contingencies (Supply Agreement with MannKind Corporation) (Details) - MannKind Corporation - Supply Commitment € in Millions, $ in Millions	Oct. 31, 2015USD ($)	Nov. 30, 2016EUR (€)	Jul. 31, 2014EUR (€)	Dec. 31, 2017USD ($)	Dec. 31, 2016USD ($)	Dec. 31, 2017EUR (€)	Dec. 31, 2015EUR (€)	Jul. 31, 2014USD ($)
Supply Commitment [Line Items]
Supply commitment in fourth quarter of 2017		€ 2.7
Supply commitment in 2018		8.9
Supply commitment in 2019		11.6
Supply commitment in 2020 and 2021		15.5
Supply commitment in 2022 and 2023		€ 19.4
Long-term Supply Commitment, Optional Renewal Period		2 years
Supply Agreement Renewal Notice Period		12 months
Recombinant Human Insulin (RHI)
Supply Commitment [Line Items]
Supply commitment annual amount committed			€ 120.1			€ 23.3	€ 27.1	$ 146
Supply Commitment, Number of Years Committed			5 years
Supply Commitment, Cancellation Fee | $	$ 0.8
Sales | $					$ 6.8
Supply Commitment, Cancellation Fee Recognized | $				$ 0.9	$ 1.5

Commitments and Contingencies83

Commitments and Contingencies (Collaboration Agreements) (Details) - Drug delivery system $ in Millions	1 Months Ended	12 Months Ended
	Oct. 31, 2017USD ($)item	Dec. 31, 2017USD ($)item
Collaborative Arrangement One [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative Agreement, Upfront Payment		$ 0.5
Collaborative Agreement, Milestone Payments		1.5
Collaborative Agreement, Contingent Obligation		$ 0.5
Collaborative Agreement, Contingent Purchase Obligation First 12 Months, Units | item		1,000,000
Purchase period		12 months
Collaborative Arrangement Two [Member]
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items]
Collaborative Agreement, Upfront Payment		$ 0.4
Collaborative Agreement, Contingent Obligation	$ 1	$ 1.2
Purchase period	3 years
Collaborative Agreement, Amount	$ 1.6
Collaborative Agreement, Contingent Purchase Obligation, Units | item	100,000

Commitments and Contingencies84

Commitments and Contingencies (Operating Lease Agreements) (Details) - USD ($) $ in Thousands	12 Months Ended
	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Operating Leased Assets [Line Items]
Operating Leases, Rent Expense	$ 3,500	$ 3,400	$ 3,300
2,018	3,333
2,019	2,624
2,020	2,321
2,021	1,523
2,022	740
Operating Leases, Future Minimum Payments Due, Total	$ 10,541
Minimum
Operating Leased Assets [Line Items]
Lessee Leasing Arrangements, Operating Leases, Renewal Term	1 year
Maximum
Operating Leased Assets [Line Items]
Lessee Leasing Arrangements, Operating Leases, Renewal Term	6 years

Commitments and Contingencies85

Commitments and Contingencies (Purchase Commitments) (Details) - USD ($) $ in Millions	1 Months Ended		12 Months Ended
	Nov. 30, 2012	Jan. 31, 2010	Dec. 31, 2017	Dec. 31, 2016
Purchase Commitment, Excluding Long-term Commitment [Line Items]
Maximum Royalty Amount Owed, Contingent On Sales of Products			$ 1.5
Commitments to Purchase Equipment and Raw Materials
Purchase Commitment, Excluding Long-term Commitment [Line Items]
Long-term Purchase Commitment, Amount			$ 50.1
Commitment to invest | ANP
Purchase Commitment, Excluding Long-term Commitment [Line Items]
Purchase Commitments Amount Fulfilled				$ 61
Commitment to develop land | ANP
Purchase Commitment, Excluding Long-term Commitment [Line Items]
Contractual Obligation	$ 15
Land-use rights | Commitment to invest | ANP
Purchase Commitment, Excluding Long-term Commitment [Line Items]
Finite-lived Intangible Assets Acquired	$ 1.3	$ 1.2

Litigation (Details)

Litigation (Details) $ in Millions	May 09, 2016USD ($)	May 04, 2016item	Apr. 07, 2015USD ($)	Oct. 31, 2011USD ($)	Sep. 21, 2011item	Dec. 31, 2017USD ($)
Enoxaparin Patent Litigation
Loss Contingencies [Line Items]
Fees and costs relating to a discovery motion	$ 0.4
False Claims Act Litigation
Loss Contingencies [Line Items]
Number of orders issued by district court | item		3
Eva Hernandez vs International Medication Systems Limited
Loss Contingencies [Line Items]
Litigation Settlement, Amount			$ 3.2
Pending Litigation [Member] | Enoxaparin Patent Litigation
Loss Contingencies [Line Items]
Number of Alleged Patent Infringements | item					2
Litigation, Plaintiff Preliminary Injunction Bond, Amount				$ 100.1
Settled Litigation [Member] | Enoxaparin Patent Litigation
Loss Contingencies [Line Items]
Litigation Settlement, Amount						$ 0

Quarterly Financial Data (Una87

Quarterly Financial Data (Unaudited) (Details) - USD ($) $ / shares in Units, shares in Thousands, $ in Thousands	3 Months Ended								12 Months Ended
	Dec. 31, 2017	Sep. 30, 2017	Jun. 30, 2017	Mar. 31, 2017	Dec. 31, 2016	Sep. 30, 2016	Jun. 30, 2016	Mar. 31, 2016	Dec. 31, 2017	Dec. 31, 2016	Dec. 31, 2015
Condensed Income Statements, Captions [Line Items]
Total net revenues	$ 60,402	$ 57,916	$ 65,187	$ 56,670	$ 63,543	$ 64,223	$ 68,033	$ 59,366	$ 240,175	$ 255,165	$ 251,519
Gross profit	20,579	20,641	26,747	22,828	19,961	27,612	31,714	24,902	90,795	104,189	77,347
Net income (loss)	$ 1,468	$ 175	$ 1,972	$ 893	$ (2,742)	$ 3,890	$ 6,895	$ 2,489	$ 4,508	$ 10,532	$ (2,787)
Weighted-average shares used to compute net income (loss) per share:
Basic (in Shares)	46,233	46,101	46,025	46,069	46,104	45,398	44,957	45,041	46,107	45,375	44,961
Diluted (in Shares)	49,330	48,215	47,866	48,057	46,104	47,953	45,968	46,810	48,367	47,504	44,961
Net income (loss) per share:
Basic (in Dollars per share)	$ 0.03	$ 0	$ 0.04	$ 0.02	$ (0.06)	$ 0.09	$ 0.15	$ 0.06	$ 0.10	$ 0.23	$ (0.06)
Diluted (in Dollars per share)	$ 0.03	$ 0	$ 0.04	$ 0.02	$ (0.06)	$ 0.08	$ 0.15	$ 0.05	$ 0.09	$ 0.22	$ (0.06)
Finished Pharmaceutical Products
Condensed Income Statements, Captions [Line Items]
Total net revenues	$ 55,985	$ 54,455	$ 63,765	$ 55,934	$ 58,853	$ 59,058	$ 63,756	$ 58,554	$ 230,139	$ 240,221	$ 224,941
Gross profit	22,317	21,310	28,866	24,310	21,057	28,621	30,598	25,824	96,803	106,100	74,146
API
Condensed Income Statements, Captions [Line Items]
Total net revenues	4,417	3,461	1,422	736	4,690	5,165	4,277	812	10,036	14,944	26,578
Gross profit	$ (1,738)	$ (669)	$ (2,119)	$ (1,482)	$ (1,096)	$ (1,009)	$ 1,116	$ (922)	$ (6,008)	$ (1,911)	$ 3,201