Pacific Biosciences of California (PACB) 8-K Pacific Biosciences of California, Inc. Announces First Quarter Financial Results

Exhibit 99.1

Pacific Biosciences of California, Inc. Announces First Quarter Financial Results

Menlo Park, Calif. - April 27, 2011 - (Globe Newswire) – Pacific Biosciences of California, Inc. (Nasdaq: PACB) today announced financial results for the quarter ended March 31, 2011.

First Quarter 2011 Financial Highlights:

During the first quarter of 2011, the Company recorded a net loss of $34.8 million, or $0.66 non-GAAP pro forma net loss per share ($0.66 GAAP net loss per share). The Company continued commercial production of the PacBioRS during the first quarter of 2011, investing $6.7 million in commercial inventories comprised of PacBio instruments and consumable products including SMRT cells and reagents. Reductions in discretionary research and development spending resulted in a $1.6 million improvement in net loss when compared to $36.4 million, or $0.76 non-GAAP pro forma net loss per share ($0.97 GAAP net loss per share), reported for the fourth quarter of 2010. Revenue, derived solely from government grants, totaled $270,000 for the first quarter of 2011 as compared to $280,000 for the fourth quarter of 2010.

Research and development expense during the first quarter of 2011 totaled $24.1 million, compared to $26.5 million for the fourth quarter of 2010. The $2.4 million, or 9%, decrease in research and development expenses during the first quarter was primarily driven by lower purchases of development materials for product testing and reduced outside engineering fees.

Selling, general, and administrative expense during the first quarter of 2011 increased to $11.1 million compared to $10.3 million for the fourth quarter of 2010. The $0.8 million, or 8%, increase during the period was primarily driven by increased headcount in sales and support functions.

Cash and investments at March 31, 2011 totaled $248.5 million compared to $283.7 million at December 31, 2010. The $35.2 million of cash used during the first quarter of 2011 primarily reflects the net loss of $31.7 million, excluding non-cash stock based compensation, $6.7 million invested in commercial inventory offset by increased deferred revenue and compensation related liabilities of $3.4 million.

Conference Call

Pacific Biosciences will host a conference call for investors on April 27, 2011 at 1:30 p.m. PDT (4:30 p.m. EDT). The conference call dial-in numbers are US: 866.356.4281 or International: 617.597.5395, access code “764 830 50”. A live webcast of the call will also be available from the Investor Relations section of www.pacb.com. A webcast replay of the conference call will also be available from the Investor Relations section of www.pacb.com approximately two hours after the call and will be available for up to thirty days.

About Pacific Biosciences

Pacific Biosciences’ mission is to transform the way humankind acquires, processes and interprets data from living systems through the design, development and commercialization of innovative tools for biological research. The company has developed a novel approach to studying the synthesis and regulation of DNA, RNA and proteins. Combining recent advances in nanofabrication, biochemistry, molecular biology, surface chemistry and optics, Pacific Biosciences has created a powerful technology platform called single molecule, real-time, or SMRT(tm), technology. SMRT technology enables real-time analysis of biomolecules with single molecule resolution, which has the potential to transform the understanding of biological systems by providing a window into these systems that has not previously been open for scientific study.

CONTACTS:

Trevin Rard	Ben Gong
650.521.8450	650.521.8203
ir@pacificbiosciences.com

Forward-Looking Statements

This press release contains forward-looking statements relating to the Company’s operations and operating results, including the statements relating to the Company’s plans for the commercial launch of the PacBioRS. You should not place undue reliance on these forward-looking statements because they involve known and unknown risks, uncertainties and other factors that are, in some cases, beyond the Company’s control and that could materially affect actual results. Factors that could materially affect actual results can be found in Pacific Biosciences of California’s recently filed Annual Report on Form 10-K, including those listed under the caption “Risk Factors.” Pacific Biosciences of California expressly disclaims any intent or obligation to update these forward-looking statements, except as required by law.

Pacific Biosciences of California, Inc.

Consolidated Balance Sheets

(Unaudited, in thousands)

	March 31,		December 31,
	2011		2010
Assets
Cash and investments	$	248,548	$	283,674
Accounts receivable		59		341
Inventory		13,539		6,864
Prepaids and other current assets		2,124		2,235
Total current assets		264,270		293,114
Property and equipment		13,932		12,311
Other assets		356		322
Total Assets	$	278,558	$	305,747
Liabilities and Stockholders Equity
Accounts payable	$	9,432	$	9,515
Deferred revenue		4,350		3,221
Accrueds and other current liabilities		10,350		8,104
Total current liabilities		24,132		20,840
Facility financing and deferred rent		5,755		5,041
Stockholders’ equity		248,671		279,866
Total Liabilities and Stockholders’ Equity	$	278,558	$	305,747

Pacific Biosciences of California, Inc.

Consolidated Statements of Operations

(Unaudited, in thousands, except share and per share data)

	Quarters Ended
	March 31,			December 31,			March 31,
	2011			2010			2010
Grant revenue	$	270		$	280		$	545
Operating expenses
Research and development		24,118			26,542			25,324
Sales, general and administrative		11,119			10,327			5,495
Total operating expense		35,237			36,869			30,819
Operating loss		(34,967	)		(36,589	)		(30,274	)
Other income (expense), net		158			170			(51	)
Net loss	$	(34,809	)	$	(36,419	)	$	(30,325	)
Basic and diluted net loss per share	$	(0.66	)	$	(0.97	)	$	(48.97	)
Shares used in computing basic and diluted net loss per share		52,756,116			37,651,526			619,250
Non-GAAP pro forma (1) basic and diluted net loss per share	$	(0.66	)	$	(0.76	)	$	(0.99	)
Non-GAAP pro forma (1) shares used in computing basic and diluted net loss per share		52,756,116			48,159,913			30,669,886

(1) Upon the closing of the Company’s initial public offering all outstanding shares of convertible preferred stock converted into shares of common stock. Non-GAAP pro forma basic and diluted net loss per share presents basic and diluted net loss per share assuming the conversion of outstanding convertible preferred stock into shares of common stock at the beginning of the respective reporting periods. The Company’s management believes that this non-GAAP pro forma information provides meaningful supplemental information that helps investors compare current results to those reported in prior periods. A reconciliation of the Company’s GAAP net loss per share to non-GAAP pro forma net loss per share is as follows:

Pacific Biosciences of California, Inc.

Consolidated Statements of Operations

(Unaudited, in thousands, except share and per share data)

	Quarters Ended
	March 31, 2011			December 31, 2010			March 31, 2010
Non-GAAP pro forma net loss per share
Numerator:
Net loss	$	(34,809	)	$	(36,419	)	$	(30,325	)
Pro forma net loss	$	(34,809	)	$	(36,419	)	$	(30,325	)
Denominator:
Shares used in computing basic and diluted net loss per share		52,756,116			37,651,526			619,250
Pro forma adjustment to reflect the assumed conversion of preferred stock into comon stock at the beginning of the reporting period.		—			10,508,387			30,050,636
Non-GAAP pro forma shares used in basic and diluted pro forma net loss per share		52,756,116			48,159,913			30,669,886
Non-GAAP pro forma basic and diluted net loss per share	$	(0.66	)	$	(0.76	)	$	(0.99	)