Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Abbott Laboratories	Common	002824100	47,853	798,619	SH		SOLE		798,619	0	0
AbbVie Inc.	Common	00287Y109	42,662	450,738	SH		SOLE		450,738	0	0
ABIOMED, Inc.	Common	003654100	1,896	6,514	SH		SOLE		6,514	0	0
AC Immune SA	Shares	H00263105	1,777	171,813	SH		SOLE		171,813	0	0
Acadia Healthcare Company, Inc.	Common	00404A109	10,673	272,400	SH		SOLE		272,400	0	0
ACADIA Pharmaceuticals Inc.	Common	004225108	2,105	93,689	SH		SOLE		93,689	0	0
Acceleron Pharma Inc.	Common	00434H108	10,678	273,098	SH		SOLE		273,098	0	0
Achillion Pharmaceuticals, Inc.	Common	00448Q201	2,285	616,000	SH		SOLE		616,000	0	0
Adamas Pharmaceuticals, Inc.	Common	00548A106	399	16,699	SH		SOLE		16,699	0	0
Adaptimmune Therapeutics plc	Sponsored ADR	00653A107	9,607	855,468	SH		SOLE		855,468	0	0
Aegerion Pharmaceuticals, Inc.	Note 2.00% 8/15/19	00767EAB8	10,010	13,000,000	PRN		SOLE		13,000,000	0	0
Aetna Inc.	Common	00817Y108	8,039	47,566	SH		SOLE		47,566	0	0
Affimed N.V.	Common	N01045108	3,340	1,805,324	SH		SOLE		1,805,324	0	0
Agios Pharmaceuticals, Inc.	Common	00847X104	230	2,810	SH		SOLE		2,810	0	0
Akebia Therapeutics, Inc.	Common	00972D105	1,266	132,849	SH		SOLE		132,849	0	0
Albireo Pharma, Inc.	Common	01345P106	4,071	125,000	SH		SOLE		125,000	0	0
Alder Biopharmaceuticals, Inc.	Common	014339105	3,555	279,950	SH		SOLE		279,950	0	0
Alexion Pharmaceuticals, Inc.	Common	015351109	55,616	498,975	SH		SOLE		498,975	0	0
Alkermes plc	Shares	G01767105	12,182	210,182	SH		SOLE		210,182	0	0
Allergan plc	Shares	G0177J108	41,877	248,836	SH		SOLE		248,836	0	0
Alliqua BioMedical, Inc.	Common	019621309	318	165,000	SH		SOLE		165,000	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	15,528	130,376	SH		SOLE		130,376	0	0
Amarin Corporation plc	Sponsored ADR	023111206	1,439	478,149	SH		SOLE		478,149	0	0
AmerisourceBergen Corporation	Common	03073E105	7,992	92,707	SH		SOLE		92,707	0	0
Amgen Inc.	Common	031162100	119,436	700,588	SH		SOLE		700,588	0	0
Amicus Therapeutics, Inc.	Common	03152W109	13,165	875,304	SH		SOLE		875,304	0	0
Anthem, Inc.	Common	036752103	20,099	91,482	SH		SOLE		91,482	0	0
ARCA biopharma, Inc.	Common	00211Y407	405	811,227	SH		SOLE		811,227	0	0
Ardelyx, Inc.	Common	039697107	3,229	639,370	SH		SOLE		639,370	0	0
Arena Pharmaceuticals, Inc.	Common	040047607	665	16,827	SH		SOLE		16,827	0	0
argenx SE	Sponsored ADR	04016X101	3,132	38,931	SH		SOLE		38,931	0	0
Array BioPharma Inc.	Common	04269X105	2,547	156,056	SH		SOLE		156,056	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	406	6,214	SH		SOLE		6,214	0	0
AstraZeneca PLC	Sponsored ADR	046353108	15,478	442,600	SH		SOLE		442,600	0	0
Avadel Pharmaceuticals plc	Sponsored ADR	05337M104	5,938	814,588	SH		SOLE		814,588	0	0
AveXis, Inc.	Common	05366U100	8,693	70,347	SH		SOLE		70,347	0	0
Baxter International Inc.	Sponsored ADR	071813109	2,599	39,965	SH		SOLE		39,965	0	0
Becton, Dickinson and Company	Common	075887109	3,739	17,254	SH		SOLE		17,254	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	8,315	49,496	SH		SOLE		49,496	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481107	394	60,000	SH		SOLE		60,000	0	0
Biogen Inc.	Common	09062X103	103,696	378,703	SH		SOLE		378,703	0	0
Biohaven Pharmaceutical Holding Company Ltd.	Common	G11196105	4,185	162,477	SH		SOLE		162,477	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	22,787	281,076	SH		SOLE		281,076	0	0
bluebird Bio, Inc.	Common	09609G100	11,322	66,308	SH		SOLE		66,308	0	0
Blueprint Medicines Corporation	Common	09627Y109	6,806	74,221	SH		SOLE		74,221	0	0
Boston Scientific Corporation	Common	101137107	12,501	457,585	SH		SOLE		457,585	0	0
Bristol-Myers Squibb Company	Common	110122108	33,252	525,722	SH		SOLE		525,722	0	0
Cardinal Health, Inc.	Common	14149Y108	395	6,300	SH		SOLE		6,300	0	0
Celgene Corporation	Common	151020104	120,687	1,352,842	SH		SOLE		1,352,842	0	0
Celldex Therapeutics, Inc.	Common	15117B103	247	105,800	SH		SOLE		105,800	0	0
Cellectis S.A.	Sponsored ADR	15117K103	8,925	283,250	SH		SOLE		283,250	0	0
Centene Corporation	Common	15135B101	24,597	230,158	SH		SOLE		230,158	0	0
Charles River Laboratories International, Inc.	Common	159864107	2,420	22,670	SH		SOLE		22,670	0	0
Cidara Therapeutics, Inc.	Common	171757107	635	158,784	SH		SOLE		158,784	0	0
Cigna Corporation	Common	125509109	9,488	56,563	SH		SOLE		56,563	0	0
Clovis Oncology, Inc.	Common	189464100	3,981	75,400	SH		SOLE		75,400	0	0
Coherus BioSciences, Inc.	Common	19249H103	2,000	181,023	SH		SOLE		181,023	0	0
Community Health Systems, Inc.	Common	203668108	808	203,935	SH		SOLE		203,935	0	0
CRISPR Therapeutics AG	Common	H17182108	6,454	141,191	SH		SOLE		141,191	0	0
CVS Health Corporation	Common	126650100	22,801	366,521	SH		SOLE		366,521	0	0
Cymabay Therapeutics, Inc.	Common	23257D103	2,208	169,962	SH		SOLE		169,962	0	0
Cytokinetics, Incorporated	Common	23282W605	992	137,797	SH		SOLE		137,797	0	0
CytomX Therapeutics, Inc.	Common	23284F105	7,541	265,045	SH		SOLE		265,045	0	0
Danaher Corporation	Common	235851102	7,328	74,847	SH		SOLE		74,847	0	0
Dermira, Inc.	Common	24983L104	1,871	234,200	SH		SOLE		234,200	0	0
Diplomat Pharmacy, Inc.	Common	25456K101	8,846	439,001	SH		SOLE		439,001	0	0
Editas Medicine, Inc.	Common	28106W103	4,568	137,801	SH		SOLE		137,801	0	0
Edwards Lifesciences Corporation	Common	28176E108	9,247	66,275	SH		SOLE		66,275	0	0
Egalet Corporation	Note 5.50% 4/1/20	28226BAB0	2,586	7,000,000	PRN		SOLE		7,000,000	0	0
Eiger BioPharmaceuticals, Inc.	Common	28249U105	452	45,854	SH		SOLE		45,854	0	0
Eli Lilly and Company	Common	532457108	37,669	486,865	SH		SOLE		486,865	0	0
Endo International plc	Shares	G30401106	5,432	914,548	SH		SOLE		914,548	0	0
Epizyme, Inc.	Common	29428V104	8,615	485,325	SH		SOLE		485,325	0	0
Esperion Therapeutics, Inc.	Common	29664W105	13,691	189,287	SH		SOLE		189,287	0	0
Evolent Health, Inc.	Class A	30050B101	1,746	122,500	SH		SOLE		122,500	0	0
Exelixis, Inc.	Common	30161Q104	8,612	388,822	SH		SOLE		388,822	0	0
Express Scripts Holding Company	Common	30219G108	7,357	106,500	SH		SOLE		106,500	0	0
FibroGen, Inc.	Common	31572Q808	4,819	104,307	SH		SOLE		104,307	0	0
Foamix Pharmaceuticals Ltd	Shares	M46135105	4,773	930,398	SH		SOLE		930,398	0	0
Foundation Medicine, Inc.	Common	350465100	500	6,353	SH		SOLE		6,353	0	0
Galapagos NV	Sponsored ADR	36315X101	9,541	95,635	SH		SOLE		95,635	0	0
Gilead Sciences, Inc.	Common	375558103	155,582	2,063,699	SH		SOLE		2,063,699	0	0
Glaukos Corporation	Common	377322102	1,698	55,079	SH		SOLE		55,079	0	0
GlaxoSmithKline plc	Shares	37733W105	15,423	394,749	SH		SOLE		394,749	0	0
Global Blood Therapeutics, Inc.	Common	37890U108	6,276	129,948	SH		SOLE		129,948	0	0
Global Medical REIT Inc.	Common	37954A204	510	73,400	SH		SOLE		73,400	0	0
GW Pharmaceuticals plc	ADS	36197T103	12,482	110,784	SH		SOLE		110,784	0	0
HCA Healthcare, Inc.	Common	40412C101	8,912	91,881	SH		SOLE		91,881	0	0
HCP, Inc.	Common	40414L109	1,057	45,500	SH		SOLE		45,500	0	0
Healthcare Realty Trust Incorporated	Common	421946104	1,884	68,000	SH		SOLE		68,000	0	0
Healthcare Trust of America, Inc.	Class A	42225P501	1,217	46,000	SH		SOLE		46,000	0	0
Henry Schein, Inc.	Common	806407102	2,110	31,400	SH		SOLE		31,400	0	0
Hologic, Inc.	Common	436440101	730	19,546	SH		SOLE		19,546	0	0
Horizon Pharma plc	Shares	G4617B105	2,313	162,900	SH		SOLE		162,900	0	0
Humana Inc.	Common	444859102	31,919	118,733	SH		SOLE		118,733	0	0
IDEXX Laboratories, Inc.	Common	45168D104	29,297	153,076	SH		SOLE		153,076	0	0
Illumina, Inc.	Common	452327109	69,718	294,892	SH		SOLE		294,892	0	0
Incyte Corporation	Common	45337C102	53,785	645,442	SH		SOLE		645,442	0	0
Innoviva, Inc.	Common	45781M101	2,694	161,603	SH		SOLE		161,603	0	0
Intellia Therapeutics, Inc.	Common	45826J105	3,530	167,381	SH		SOLE		167,381	0	0
Intuitive Surgical, Inc.	Common	46120E602	5,870	14,218	SH		SOLE		14,218	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	7,303	165,677	SH		SOLE		165,677	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	18,494	122,482	SH		SOLE		122,482	0	0
Johnson & Johnson	Common	478160104	114,448	893,082	SH		SOLE		893,082	0	0
Jounce Therapeutics, Inc.	Common	481116101	226	10,127	SH		SOLE		10,127	0	0
Koninklijke Philips N.V.	NY Registry Shares	500472303	2,886	75,335	SH		SOLE		75,335	0	0
Lexicon Pharmaceuticals, Inc.	Common	528872302	1,980	231,054	SH		SOLE		231,054	0	0
LTC Properties, Inc.	Common	502175102	7,968	209,673	SH		SOLE		209,673	0	0
Mallinckrodt plc	Shares	G5785G107	896	61,900	SH		SOLE		61,900	0	0
Masimo Corporation	Common	574795100	3,665	41,666	SH		SOLE		41,666	0	0
McKesson Corporation	Common	58155Q103	13,918	98,797	SH		SOLE		98,797	0	0
Medical Properties Trust, Inc.	Common	58463J304	11,162	858,586	SH		SOLE		858,586	0	0
The Medicines Company	Common	584688105	9,170	278,391	SH		SOLE		278,391	0	0
Medtronic plc	Shares	G5960L103	41,892	522,211	SH		SOLE		522,211	0	0
Merck & Co., Inc.	Common	58933Y105	69,941	1,284,022	SH		SOLE		1,284,022	0	0
Merus B.V.	Common	N5749R100	8,879	479,150	SH		SOLE		479,150	0	0
Molecular Templates, Inc.	Common	608550109	423	52,891	SH		SOLE		52,891	0	0
Mylan N.V.	Shares	N59465109	71,099	1,726,967	SH		SOLE		1,726,967	0	0
Myovant Sciences Ltd.	Common	G637AM102	3,201	150,471	SH		SOLE		150,471	0	0
NanoString Technologies, Inc.	Common	63009R109	558	74,250	SH		SOLE		74,250	0	0
Natera, Inc.	Common	632307104	962	103,731	SH		SOLE		103,731	0	0
Natus Medical Incorporated	Common	639050103	381	11,335	SH		SOLE		11,335	0	0
Nektar Therapeutics	Common	640268108	13,231	124,517	SH		SOLE		124,517	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	23,172	279,419	SH		SOLE		279,419	0	0
Nevro Corp.	Common	64157F103	4,593	52,990	SH		SOLE		52,990	0	0
New Senior Investment Group Inc.	Common	648691103	7,230	883,919	SH		SOLE		883,919	0	0
NewLink Genetics Corporation	Common	651511107	1,486	205,026	SH		SOLE		205,026	0	0
Novartis AG	Sponsored ADR	66987V109	28,380	351,020	SH		SOLE		351,020	0	0
Novavax, Inc.	Common	670002104	1,199	571,000	SH		SOLE		571,000	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	6,693	135,900	SH		SOLE		135,900	0	0
NuCana plc	Sponsored ADR	67022C106	464	24,536	SH		SOLE		24,536	0	0
Omega Healthcare Investors, Inc.	Common	681936100	15,677	579,785	SH		SOLE		579,785	0	0
Ovid Therapeutics Inc.	Common	690469101	3,788	535,824	SH		SOLE		535,824	0	0
Perrigo Company plc	Shares	G97822103	3,109	37,300	SH		SOLE		37,300	0	0
Pfizer Inc.	Common	717081103	72,823	2,051,943	SH		SOLE		2,051,943	0	0
Physicians Realty Trust	Common	71943U104	4,131	265,336	SH		SOLE		265,336	0	0
Pieris Pharmaceuticals, Inc.	Common	720795103	14,236	2,087,380	SH		SOLE		2,087,380	0	0
Portola Pharmaceuticals, Inc.	Common	737010108	2,939	89,978	SH		SOLE		89,978	0	0
PRA Health Sciences, Inc.	Common	69354M108	2,693	32,460	SH		SOLE		32,460	0	0
Protagonist Therapeutics, Inc.	Common	74366E102	1,882	219,042	SH		SOLE		219,042	0	0
PTC Therapeutics, Inc.	Common	69366J200	658	24,299	SH		SOLE		24,299	0	0
Puma Biotechnology, Inc.	Common	74587V107	3,810	55,985	SH		SOLE		55,985	0	0
Quorum Health Corporation	Common	74909E106	194	23,725	SH		SOLE		23,725	0	0
Quotient Limited	Shares	G73268107	2,084	442,461	SH		SOLE		442,461	0	0
Ra Pharmaceuticals, Inc.	Common	74933V108	1,798	338,565	SH		SOLE		338,565	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	48,059	139,560	SH		SOLE		139,560	0	0
ResMed Inc.	Common	761152107	3,330	33,819	SH		SOLE		33,819	0	0
Revance Therapeutics, Inc.	Common	761330109	1,335	43,329	SH		SOLE		43,329	0	0
The RMR Group Inc.	Class A	74967R106	520	7,441	SH		SOLE		7,441	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	12,789	724,606	SH		SOLE		724,606	0	0
Sage Therapeutics, Inc.	Common	78667J108	20,077	124,650	SH		SOLE		124,650	0	0
Sanofi	Sponsored ADR	80105N105	7,210	179,900	SH		SOLE		179,900	0	0
Sarepta Therapeutics, Inc.	Common	803607100	28,044	378,516	SH		SOLE		378,516	0	0
Seattle Genetics, Inc.	Common	812578102	18,136	346,499	SH		SOLE		346,499	0	0
Senior Housing Properties Trust	Shares	81721M109	10,125	646,554	SH		SOLE		646,554	0	0
Shire plc	Sponsored ADR	82481R106	17,274	115,629	SH		SOLE		115,629	0	0
Smith & Nephew plc	Sponsored ADR	83175M205	1,684	44,148	SH		SOLE		44,148	0	0
Spark Therapeutics, Inc.	Common	84652J103	1,468	22,046	SH		SOLE		22,046	0	0
SPDR S&P Biotech ETF	S&P Biotech ETF	78464A870	21,973	250,460	SH		SOLE		250,460	0	0
STERIS plc	Shares	G84720104	1,551	16,612	SH		SOLE		16,612	0	0
Stryker Corporation	Common	863667101	10,340	64,258	SH		SOLE		64,258	0	0
Syndax Pharmaceuticals, Inc.	Common	87164F105	2,846	200,000	SH		SOLE		200,000	0	0
Teleflex Incorporated	Common	879369106	633	2,482	SH		SOLE		2,482	0	0
Teligent, Inc.	Common	87960W104	1,853	551,429	SH		SOLE		551,429	0	0
Tenet Healthcare Corporation	Common	88033G407	3,989	164,500	SH		SOLE		164,500	0	0
TESARO, Inc.	Common	881569107	3,291	57,595	SH		SOLE		57,595	0	0
Tetraphase Pharmaceuticals, Inc.	Common	88165N105	2,638	859,322	SH		SOLE		859,322	0	0
Teva Pharmaceutical Industries Limited	Sponsored ADR	881624209	18,512	1,083,223	SH		SOLE		1,083,223	0	0
TherapeuticsMD, Inc.	Common	88338N107	2,283	468,769	SH		SOLE		468,769	0	0
Theravance Biopharma, Inc.	Common	G8807B106	196	8,083	SH		SOLE		8,083	0	0
Thermo Fisher Scientific Inc.	Common	883556102	30,526	147,855	SH		SOLE		147,855	0	0
Trillium Therapeutics Inc.	Common	89620X506	3,372	468,399	SH		SOLE		468,399	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	7,575	148,558	SH		SOLE		148,558	0	0
uniQure N.V.	Shares	N90064101	4,694	199,750	SH		SOLE		199,750	0	0
United Therapeutics Corporation	Common	91307C102	4,636	41,261	SH		SOLE		41,261	0	0
Unitedhealth Group Incorporated	Common	91324P102	75,396	352,317	SH		SOLE		352,317	0	0
Valeant Pharmaceuticals International, Inc.	Common	91911K102	3,057	192,000	SH		SOLE		192,000	0	0
Varian Medical Systems, Inc.	Common	92220P105	621	5,065	SH		SOLE		5,065	0	0
Ventas, Inc.	Common	92276F100	4,358	87,996	SH		SOLE		87,996	0	0
Verona Pharma plc	Sponsored ADR	925050106	5,500	275,000	SH		SOLE		275,000	0	0
Vertex Pharmaceuticals Incorporated	Common	92532F100	100,083	614,084	SH		SOLE		614,084	0	0
Welltower Inc.	6.50% Preferred Perpetual	95040Q203	11,128	200,000	SH		SOLE		200,000	0	0
Welltower Inc.	Common	95040Q104	1,165	21,400	SH		SOLE		21,400	0	0
Wright Medical Group N.V.	Ordinary Shares	N96617118	5,293	266,781	SH		SOLE		266,781	0	0
Xencor, Inc.	Common	98401F105	600	20,000	SH		SOLE		20,000	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	1,372	280,000	SH		SOLE		280,000	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	8,950	82,080	SH		SOLE		82,080	0	0