Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Abbott Laboratories	Common	002824100	38,242	627,019	SH		SOLE		627,019	0	0
AbbVie Inc.	Common	00287Y109	47,590	513,658	SH		SOLE		513,658	0	0
AC Immune SA	Shares	H00263105	1,598	171,813	SH		SOLE		171,813	0	0
Acadia Healthcare Company, Inc.	Common	00404A109	11,144	272,400	SH		SOLE		272,400	0	0
ACADIA Pharmaceuticals Inc.	Common	004225108	1,431	93,689	SH		SOLE		93,689	0	0
Acceleron Pharma Inc.	Common	00434H108	8,286	170,766	SH		SOLE		170,766	0	0
Achillion Pharmaceuticals, Inc.	Common	00448Q201	1,743	616,000	SH		SOLE		616,000	0	0
Adaptimmune Therapeutics plc	Sponsored ADR	00653A107	10,154	855,468	SH		SOLE		855,468	0	0
Aegerion Pharmaceuticals, Inc.	Note 2.00% 8/15/19	00767EAB8	8,436	13,000,000	PRN		SOLE		13,000,000	0	0
Aerpio Pharmaceuticals, Inc.	Common	00810B105	3,175	765,000	SH		SOLE		765,000	0	0
Aetna Inc.	Common	00817Y108	17,822	97,122	SH		SOLE		97,122	0	0
Affimed N.V.	Common	N01045108	2,681	1,624,792	SH		SOLE		1,624,792	0	0
Agios Pharmaceuticals, Inc.	Common	00847X104	237	2,810	SH		SOLE		2,810	0	0
Akebia Therapeutics, Inc.	Common	00972D105	2,661	266,612	SH		SOLE		266,612	0	0
Albireo Pharma, Inc.	Common	01345P106	4,438	125,000	SH		SOLE		125,000	0	0
Alexion Pharmaceuticals, Inc.	Common	015351109	54,429	438,416	SH		SOLE		438,416	0	0
Alkermes plc	Shares	G01767105	7,040	171,042	SH		SOLE		171,042	0	0
Allergan plc	Shares	G0177J108	41,486	248,836	SH		SOLE		248,836	0	0
Alliqua BioMedical, Inc.	Common	019621309	338	165,000	SH		SOLE		165,000	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	12,841	130,376	SH		SOLE		130,376	0	0
Amarin Corporation plc	Sponsored ADR	023111206	1,477	478,149	SH		SOLE		478,149	0	0
AmerisourceBergen Corporation	Common	03073E105	7,905	92,707	SH		SOLE		92,707	0	0
Amgen Inc.	Common	031162100	129,322	700,588	SH		SOLE		700,588	0	0
Amicus Therapeutics, Inc.	Common	03152W109	13,672	875,304	SH		SOLE		875,304	0	0
Anthem, Inc.	Common	036752103	26,334	110,633	SH		SOLE		110,633	0	0
ARCA biopharma, Inc.	Common	00211Y407	451	811,227	SH		SOLE		811,227	0	0
Ardelyx, Inc.	Common	039697107	2,366	639,370	SH		SOLE		639,370	0	0
Arena Pharmaceuticals, Inc.	Common	040047607	4,088	93,767	SH		SOLE		93,767	0	0
argenx SE	Sponsored ADR	04016X101	3,226	38,931	SH		SOLE		38,931	0	0
Array BioPharma Inc.	Common	04269X105	4,297	256,056	SH		SOLE		256,056	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	2,921	43,914	SH		SOLE		43,914	0	0
AstraZeneca PLC	Sponsored ADR	046353108	27,347	778,888	SH		SOLE		778,888	0	0
Avadel Pharmaceuticals plc	Sponsored ADR	05337M104	4,993	814,588	SH		SOLE		814,588	0	0
Bausch Health Companies Inc.	Common	91911K102	4,462	192,000	SH		SOLE		192,000	0	0
Baxter International Inc.	Sponsored ADR	071813109	9,904	134,124	SH		SOLE		134,124	0	0
Becton, Dickinson and Company	Common	075887109	12,691	52,978	SH		SOLE		52,978	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	8,422	54,785	SH		SOLE		54,785	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481107	443	60,000	SH		SOLE		60,000	0	0
Biogen Inc.	Common	09062X103	117,244	403,955	SH		SOLE		403,955	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	13,239	140,538	SH		SOLE		140,538	0	0
bluebird bio, Inc.	Common	09609G100	11,331	72,198	SH		SOLE		72,198	0	0
Blueprint Medicines Corporation	Common	09627Y109	9,268	146,001	SH		SOLE		146,001	0	0
Boston Scientific Corporation	Common	101137107	14,963	457,585	SH		SOLE		457,585	0	0
Bristol-Myers Squibb Company	Common	110122108	36,028	651,030	SH		SOLE		651,030	0	0
Cardinal Health, Inc.	Common	14149Y108	308	6,300	SH		SOLE		6,300	0	0
Celgene Corporation	Common	151020104	99,392	1,251,470	SH		SOLE		1,251,470	0	0
Celldex Therapeutics, Inc.	Common	15117B103	53	105,800	SH		SOLE		105,800	0	0
Cellectis S.A.	Sponsored ADR	15117K103	8,995	317,950	SH		SOLE		317,950	0	0
Centene Corporation	Common	15135B101	22,772	184,819	SH		SOLE		184,819	0	0
Charles River Laboratories International, Inc.	Common	159864107	2,545	22,670	SH		SOLE		22,670	0	0
Cidara Therapeutics, Inc.	Common	171757107	826	158,784	SH		SOLE		158,784	0	0
Cigna Corporation	Common	125509109	6,876	40,461	SH		SOLE		40,461	0	0
Clearside Biomedical, Inc.	Common	185063104	884	82,665	SH		SOLE		82,665	0	0
Clovis Oncology, Inc.	Common	189464100	3,428	75,400	SH		SOLE		75,400	0	0
Coherus Biosciences, Inc.	Common	19249H103	3,372	240,843	SH		SOLE		240,843	0	0
Community Health Systems, Inc.	Common	203668108	677	203,935	SH		SOLE		203,935	0	0
CRISPR Therapeutics AG	Common	H17182108	10,480	178,348	SH		SOLE		178,348	0	0
CVS Health Corporation	Common	126650100	23,586	366,521	SH		SOLE		366,521	0	0
CymaBay Therapeutics, Inc.	Common	23257D103	2,281	169,962	SH		SOLE		169,962	0	0
Danaher Corporation	Common	235851102	19,033	192,871	SH		SOLE		192,871	0	0
Depomed, Inc.	Common	249908104	420	62,973	SH		SOLE		62,973	0	0
Dermira, Inc.	Common	24983L104	2,155	234,200	SH		SOLE		234,200	0	0
Diplomat Pharmacy, Inc.	Common	25456K101	11,221	439,001	SH		SOLE		439,001	0	0
Editas Medicine, Inc.	Common	28106W103	4,937	137,801	SH		SOLE		137,801	0	0
Edwards Lifesciences Corporation	Common	28176E108	9,648	66,275	SH		SOLE		66,275	0	0
Egalet Corporation	Note 5.50% 4/1/20	28226BAB0	2,445	7,000,000	PRN		SOLE		7,000,000	0	0
Eli Lilly and Company	Common	532457108	33,288	390,108	SH		SOLE		390,108	0	0
Endo International plc	Shares	G30401106	10,169	1,078,414	SH		SOLE		1,078,414	0	0
Epizyme, Inc.	Common	29428V104	6,576	485,325	SH		SOLE		485,325	0	0
Esperion Therapeutics, Inc.	Common	29664W105	7,418	189,287	SH		SOLE		189,287	0	0
Evolent Health, Inc.	Class A	30050B101	2,579	122,500	SH		SOLE		122,500	0	0
Exelixis, Inc.	Common	30161Q104	9,211	428,022	SH		SOLE		428,022	0	0
Express Scripts Holding Company	Common	30219G108	8,223	106,500	SH		SOLE		106,500	0	0
FibroGen, Inc.	Common	31572Q808	11,156	178,207	SH		SOLE		178,207	0	0
Foamix Pharmaceuticals Ltd.	Shares	M46135105	4,661	930,398	SH		SOLE		930,398	0	0
Galapagos NV	Sponsored ADR	36315X101	8,003	86,815	SH		SOLE		86,815	0	0
Gilead Sciences, Inc.	Common	375558103	146,192	2,063,699	SH		SOLE		2,063,699	0	0
GlaxoSmithKline plc	Shares	37733W105	14,471	359,000	SH		SOLE		359,000	0	0
Global Blood Therapeutics, Inc.	Common	37890U108	2,684	59,390	SH		SOLE		59,390	0	0
Global Medical REIT Inc.	Common	37954A204	650	73,400	SH		SOLE		73,400	0	0
GW Pharmaceuticals plc	ADS	36197T103	9,977	71,497	SH		SOLE		71,497	0	0
HCA Healthcare, Inc.	Common	40412C101	7,704	75,090	SH		SOLE		75,090	0	0
HCP, Inc.	Common	40414L109	1,175	45,500	SH		SOLE		45,500	0	0
Healthcare Realty Trust Incorporated	Common	421946104	1,977	68,000	SH		SOLE		68,000	0	0
Healthcare Trust of America, Inc.	Class A	42225P501	1,240	46,000	SH		SOLE		46,000	0	0
Henry Schein, Inc.	Common	806407102	2,281	31,400	SH		SOLE		31,400	0	0
Hologic, Inc.	Common	436440101	777	19,546	SH		SOLE		19,546	0	0
Horizon Pharma plc	Shares	G4617B105	2,698	162,900	SH		SOLE		162,900	0	0
Humana Inc.	Common	444859102	31,267	105,053	SH		SOLE		105,053	0	0
IDEXX Laboratories, Inc.	Common	45168D104	28,247	129,608	SH		SOLE		129,608	0	0
Illumina, Inc.	Common	452327109	79,456	284,492	SH		SOLE		284,492	0	0
Incyte Corporation	Common	45337C102	43,245	645,442	SH		SOLE		645,442	0	0
Innoviva, Inc.	Common	45781M101	2,230	161,603	SH		SOLE		161,603	0	0
Intellia Therapeutics, Inc.	Common	45826J105	4,580	167,381	SH		SOLE		167,381	0	0
Intuitive Surgical, Inc.	Common	46120E602	11,234	23,479	SH		SOLE		23,479	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	3,452	82,838	SH		SOLE		82,838	0	0
Iovance Biotherapeutics, Inc.	Common	462260100	427	33,395	SH		SOLE		33,395	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	19,031	110,452	SH		SOLE		110,452	0	0
Johnson & Johnson	Common	478160104	108,367	893,082	SH		SOLE		893,082	0	0
Jounce Therapeutics, Inc.	Common	481116101	78	10,127	SH		SOLE		10,127	0	0
LeMaitre Vascular, Inc.	Common	525558201	909	27,150	SH		SOLE		27,150	0	0
LivaNova PLC	Common	G5509L101	628	6,287	SH		SOLE		6,287	0	0
Loxo Oncology, Inc.	Common	548862101	1,798	10,365	SH		SOLE		10,365	0	0
LTC Properties, Inc.	Common	502175102	8,961	209,673	SH		SOLE		209,673	0	0
Mallinckrodt plc	Shares	G5785G107	1,155	61,900	SH		SOLE		61,900	0	0
Masimo Corporation	Common	574795100	4,689	48,020	SH		SOLE		48,020	0	0
McKesson Corporation	Common	58155Q103	13,180	98,797	SH		SOLE		98,797	0	0
Medical Properties Trust, Inc.	Common	58463J304	12,055	858,586	SH		SOLE		858,586	0	0
The Medicines Company	Common	584688105	8,762	238,741	SH		SOLE		238,741	0	0
Medtronic plc	Shares	G5960L103	36,272	423,693	SH		SOLE		423,693	0	0
Merck & Co., Inc.	Common	58933Y105	77,940	1,284,022	SH		SOLE		1,284,022	0	0
Merus N.V.	Common	N5749R100	9,425	414,115	SH		SOLE		414,115	0	0
Molecular Templates, Inc.	Common	608550109	754	144,110	SH		SOLE		144,110	0	0
Mylan N.V.	Shares	N59465109	59,885	1,657,017	SH		SOLE		1,657,017	0	0
NanoString Technologies, Inc.	Common	63009R109	1,016	74,250	SH		SOLE		74,250	0	0
Nektar Therapeutics	Common	640268108	9,218	188,769	SH		SOLE		188,769	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	26,502	269,769	SH		SOLE		269,769	0	0
Nevro Corp.	Common	64157F103	4,231	52,990	SH		SOLE		52,990	0	0
New Senior Investment Group Inc.	Common	648691103	4,004	528,919	SH		SOLE		528,919	0	0
NewLink Genetics Corporation	Common	651511107	976	205,026	SH		SOLE		205,026	0	0
Novartis AG	Sponsored ADR	66987V109	22,346	295,820	SH		SOLE		295,820	0	0
Novavax, Inc.	Common	670002104	765	571,000	SH		SOLE		571,000	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	6,268	135,900	SH		SOLE		135,900	0	0
NuCana plc	Common	67022C106	187	9,823	SH		SOLE		9,823	0	0
NuVasive, Inc.	Common	670704105	1,021	19,580	SH		SOLE		19,580	0	0
Omega Healthcare Investors, Inc.	Common	681936100	17,973	579,785	SH		SOLE		579,785	0	0
Ovid Therapeutics Inc.	Common	690469101	4,179	535,824	SH		SOLE		535,824	0	0
Perrigo Company plc	Shares	G97822103	2,720	37,300	SH		SOLE		37,300	0	0
Pfizer Inc.	Common	717081103	85,609	2,359,687	SH		SOLE		2,359,687	0	0
Physicians Realty Trust	Common	71943U104	6,233	391,016	SH		SOLE		391,016	0	0
Pieris Pharmaceuticals, Inc.	Common	720795103	10,583	2,087,380	SH		SOLE		2,087,380	0	0
Portola Pharmaceuticals, Inc.	Common	737010108	3,398	89,978	SH		SOLE		89,978	0	0
PRA Health Sciences, Inc.	Common	69354M108	3,030	32,460	SH		SOLE		32,460	0	0
Protagonist Therapeutics, Inc.	Common	74366E102	1,472	219,042	SH		SOLE		219,042	0	0
Puma Biotechnology, Inc.	Common	74587V107	4,930	83,340	SH		SOLE		83,340	0	0
Quorum Health Corporation	Common	74909E106	119	23,725	SH		SOLE		23,725	0	0
Ra Pharmaceuticals, Inc.	Common	74933V108	2,189	219,952	SH		SOLE		219,952	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	50,450	146,237	SH		SOLE		146,237	0	0
ResMed Inc.	Common	761152107	6,073	58,630	SH		SOLE		58,630	0	0
Revance Therapeutics, Inc.	Common	761330109	2,139	77,919	SH		SOLE		77,919	0	0
The RMR Group Inc.	Class A	74967R106	584	7,441	SH		SOLE		7,441	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	15,746	724,606	SH		SOLE		724,606	0	0
Sage Therapeutics, Inc.	Common	78667J108	22,480	143,614	SH		SOLE		143,614	0	0
Sangamo Therapeutics, Inc.	Common	800677106	1,711	120,512	SH		SOLE		120,512	0	0
Sanofi	Common	80105N105	7,198	179,900	SH		SOLE		179,900	0	0
Sarepta Therapeutics, Inc.	Common	803607100	30,995	234,489	SH		SOLE		234,489	0	0
Seattle Genetics, Inc.	Common	812578102	18,550	279,417	SH		SOLE		279,417	0	0
Senior Housing Properties Trust	Shares	81721M109	11,696	646,554	SH		SOLE		646,554	0	0
Shire plc	Shares	82481R106	6,113	36,216	SH		SOLE		36,216	0	0
Smith & Nephew plc	Sponsored ADR	83175M205	1,657	44,148	SH		SOLE		44,148	0	0
Spark Therapeutics, Inc.	Common	84652J103	1,825	22,046	SH		SOLE		22,046	0	0
SPDR S&P Biotech ETF	S&P Biotech ETF	78464A870	23,841	250,460	SH		SOLE		250,460	0	0
STERIS plc	Shares	G84720104	2,353	22,403	SH		SOLE		22,403	0	0
Stryker Corporation	Common	863667101	23,072	136,631	SH		SOLE		136,631	0	0
Syndax Pharmaceuticals, Inc.	Common	87164F105	1,404	200,000	SH		SOLE		200,000	0	0
Teleflex Incorporated	Common	879369106	1,711	6,379	SH		SOLE		6,379	0	0
Teligent, Inc.	Common	87960W104	3,136	906,362	SH		SOLE		906,362	0	0
Tenet Healthcare Corporation	Common	88033G407	5,522	164,500	SH		SOLE		164,500	0	0
TESARO, Inc.	Common	881569107	4,223	94,970	SH		SOLE		94,970	0	0
Tetraphase Pharmaceuticals, Inc.	Common	88165N105	3,068	859,322	SH		SOLE		859,322	0	0
Teva Pharmaceutical Industries Limited	Sponsored ADR	881624209	26,359	1,083,843	SH		SOLE		1,083,843	0	0
TherapeuticsMD, Inc.	Common	88338N107	1,463	234,384	SH		SOLE		234,384	0	0
Theravance Biopharma, Inc.	Common	G8807B106	183	8,083	SH		SOLE		8,083	0	0
Thermo Fisher Scientific Inc.	Common	883556102	31,629	152,695	SH		SOLE		152,695	0	0
Trillium Therapeutics Inc.	Common	89620X506	2,810	468,399	SH		SOLE		468,399	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	5,916	76,958	SH		SOLE		76,958	0	0
uniQure N.V.	Shares	N90064101	1,427	37,741	SH		SOLE		37,741	0	0
United Therapeutics Corporation	Class B	91307C102	4,669	41,261	SH		SOLE		41,261	0	0
Unitedhealth Group Incorporated	Common	91324P102	104,347	425,317	SH		SOLE		425,317	0	0
Varian Medical Systems, Inc.	Common	92220P105	2,983	26,227	SH		SOLE		26,227	0	0
Ventas, Inc.	Common	92276F100	5,609	98,496	SH		SOLE		98,496	0	0
Verona Pharma plc	Sponsored ADR	925050106	3,781	275,000	SH		SOLE		275,000	0	0
Vertex Pharmaceuticals Incorporated	Common	92532F100	98,835	581,522	SH		SOLE		581,522	0	0
Welltower Inc.	6.50% Preferred Perpetual	95040Q203	11,890	200,000	SH		SOLE		200,000	0	0
Welltower Inc.	Common	95040Q104	2,856	45,560	SH		SOLE		45,560	0	0
Wright Medical Group N.V.	Ordinary Shares	N96617118	6,926	266,781	SH		SOLE		266,781	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	1,507	163,819	SH		SOLE		163,819	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	13,244	118,846	SH		SOLE		118,846	0	0
Zoetis, Inc.	Class A	98978V103	3,046	35,760	SH		SOLE		35,760	0	0
Zogenix, Inc.	Common	98978L204	1,563	35,352	SH		SOLE		35,352	0	0