Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Abbott Laboratories	Common	002824100	28,737	391,719	SH		SOLE		391,719	0	0
AbbVie Inc.	Common	00287Y109	46,541	492,078	SH		SOLE		492,078	0	0
ABIOMED, Inc.	Common	003654100	1,687	3,750	SH		SOLE		3,750	0	0
AC Immune SA	Shares	H00263105	1,375	171,813	SH		SOLE		171,813	0	0
Acadia Healthcare Company, Inc.	Common	00404A109	9,588	272,400	SH		SOLE		272,400	0	0
ACADIA Pharmaceuticals Inc.	Common	004225108	1,945	93,689	SH		SOLE		93,689	0	0
Acceleron Pharma Inc.	Common	00434H108	9,773	170,766	SH		SOLE		170,766	0	0
Achillion Pharmaceuticals, Inc.	Common	00448Q201	1,710	464,761	SH		SOLE		464,761	0	0
Adaptimmune Therapeutics plc	Sponsored ADR	00653A107	4,768	351,618	SH		SOLE		351,618	0	0
Aegerion Pharmaceuticals, Inc.	Note 2.00% 8/15/19	00767EAB8	9,740	13,000,000	PRN		SOLE		13,000,000	0	0
Aerie Pharmaceuticals, Inc.	Common	00771V108	2,386	38,770	SH		SOLE		38,770	0	0
Aerpio Pharmaceuticals, Inc.	Common	00810B105	2,364	765,000	SH		SOLE		765,000	0	0
Aetna Inc.	Common	00817Y108	16,966	83,637	SH		SOLE		83,637	0	0
Affimed NV	Common	N01045108	1,105	254,000	SH		SOLE		254,000	0	0
Agilent Technologies, Inc.	Common	00846U101	4,007	56,800	SH		SOLE		56,800	0	0
Agios Pharmaceuticals, Inc.	Common	00847X104	2,612	33,870	SH		SOLE		33,870	0	0
Akebia Therapeutics, Inc.	Common	00972D105	2,354	266,612	SH		SOLE		266,612	0	0
Albireo Pharma, Inc.	Common	01345P106	4,120	125,000	SH		SOLE		125,000	0	0
Alexion Pharmaceuticals, Inc.	Common	015351109	60,944	438,416	SH		SOLE		438,416	0	0
Align Technology, Inc.	Common	016255101	4,399	11,244	SH		SOLE		11,244	0	0
Alkermes plc	Shares	G01767105	7,259	171,042	SH		SOLE		171,042	0	0
Allergan plc	Shares	G0177J108	47,398	248,836	SH		SOLE		248,836	0	0
Alliqua BioMedical, Inc.	Common	019621309	375	165,000	SH		SOLE		165,000	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	11,043	126,176	SH		SOLE		126,176	0	0
Amarin Corporation plc	Sponsored ADR	023111206	12,268	754,049	SH		SOLE		754,049	0	0
AmerisourceBergen Corporation	Common	03073E105	10,311	111,807	SH		SOLE		111,807	0	0
Amgen Inc.	Common	031162100	140,513	677,855	SH		SOLE		677,855	0	0
Amicus Therapeutics, Inc.	Common	03152W109	10,582	875,304	SH		SOLE		875,304	0	0
AnaptysBio, Inc.	Common	032724106	4,580	45,910	SH		SOLE		45,910	0	0
Anthem, Inc.	Common	036752103	38,681	141,147	SH		SOLE		141,147	0	0
ARCA biopharma, Inc.	Common	00211Y407	454	811,227	SH		SOLE		811,227	0	0
Ardelyx, Inc.	Common	039697107	2,781	639,370	SH		SOLE		639,370	0	0
Arena Pharmaceuticals, Inc.	Common	040047607	4,315	93,767	SH		SOLE		93,767	0	0
argenx SE	Sponsored ADR	04016X101	1,152	15,188	SH		SOLE		15,188	0	0
ArQule, Inc.	Common	04269E107	1,415	250,000	SH		SOLE		250,000	0	0
Array BioPharma Inc.	Common	04269X105	5,535	364,166	SH		SOLE		364,166	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	4,656	65,714	SH		SOLE		65,714	0	0
Assertio Therapeutics, Inc.	Common	04545L107	6	1,000	SH		SOLE		1,000	0	0
AstraZeneca PLC	Sponsored ADR	046353108	28,436	718,624	SH		SOLE		718,624	0	0
Athenex, Inc.	Common	04685N103	708	45,530	SH		SOLE		45,530	0	0
Audentes Therapeutics, Inc.	Common	05070R104	1,534	38,740	SH		SOLE		38,740	0	0
Avadel Pharmaceuticals plc	Sponsored ADR	05337M104	3,576	814,588	SH		SOLE		814,588	0	0
Bausch Health Companies Inc.	Common	071734107	4,929	192,000	SH		SOLE		192,000	0	0
Baxter International Inc.	Sponsored ADR	071813109	11,258	146,040	SH		SOLE		146,040	0	0
Becton, Dickinson and Company	Common	075887109	16,750	64,178	SH		SOLE		64,178	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	14,769	85,755	SH		SOLE		85,755	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481107	370	60,000	SH		SOLE		60,000	0	0
Biogen Inc.	Common	09062X103	138,286	391,402	SH		SOLE		391,402	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	13,628	140,538	SH		SOLE		140,538	0	0
bluebird bio, Inc.	Common	09609G100	12,817	87,788	SH		SOLE		87,788	0	0
Blueprint Medicines Corporation	Common	09627Y109	11,397	146,001	SH		SOLE		146,001	0	0
Boston Scientific Corporation	Common	101137107	17,132	444,991	SH		SOLE		444,991	0	0
Bristol-Myers Squibb Company	Common	110122108	22,725	366,064	SH		SOLE		366,064	0	0
Cardinal Health, Inc.	Common	14149Y108	340	6,300	SH		SOLE		6,300	0	0
Celgene Corporation	Common	151020104	117,442	1,312,350	SH		SOLE		1,312,350	0	0
Celldex Therapeutics, Inc.	Common	15117B103	48	105,800	SH		SOLE		105,800	0	0
Cellectis SA	Sponsored ADR	15117K103	7,873	278,988	SH		SOLE		278,988	0	0
Centene Corporation	Common	15135B101	24,159	166,869	SH		SOLE		166,869	0	0
Charles River Laboratories International, Inc.	Common	159864107	3,050	22,670	SH		SOLE		22,670	0	0
Cidara Therapeutics, Inc.	Common	171757107	699	158,784	SH		SOLE		158,784	0	0
Cigna Corporation	Common	125509109	8,426	40,461	SH		SOLE		40,461	0	0
Clearside Biomedical, Inc.	Common	185063104	508	82,665	SH		SOLE		82,665	0	0
Clovis Oncology, Inc.	Common	189464100	2,214	75,400	SH		SOLE		75,400	0	0
Coherus Biosciences, Inc.	Common	19249H103	2,472	149,820	SH		SOLE		149,820	0	0
Community Health Systems, Inc.	Common	203668108	706	203,935	SH		SOLE		203,935	0	0
Concert Pharmaceuticals, Inc.	Common	206022105	1,346	90,724	SH		SOLE		90,724	0	0
CRISPR Therapeutics AG	Common	H17182108	7,910	178,348	SH		SOLE		178,348	0	0
CVS Health Corporation	Common	126650100	31,575	401,101	SH		SOLE		401,101	0	0
CymaBay Therapeutics, Inc.	Common	23257D103	1,883	169,962	SH		SOLE		169,962	0	0
Danaher Corporation	Common	235851102	22,750	209,371	SH		SOLE		209,371	0	0
DENTSPLY SIRONA Inc.	Common	24906P109	2,174	57,600	SH		SOLE		57,600	0	0
Dermira, Inc.	Common	24983L104	2,553	234,200	SH		SOLE		234,200	0	0
Diplomat Pharmacy, Inc.	Common	25456K101	8,521	439,001	SH		SOLE		439,001	0	0
Editas Medicine, Inc.	Common	28106W103	2,440	76,668	SH		SOLE		76,668	0	0
Edwards Lifesciences Corporation	Common	28176E108	13,353	76,696	SH		SOLE		76,696	0	0
Egalet Corporation	Note 5.50% 4/1/20	28226BAB0	700	7,000,000	PRN		SOLE		7,000,000	0	0
Eidos Therapeutics, Inc.	Common	28249H104	278	27,900	SH		SOLE		27,900	0	0
Eli Lilly and Company	Common	532457108	23,226	216,442	SH		SOLE		216,442	0	0
Endo International plc	Shares	G30401106	17,151	1,019,048	SH		SOLE		1,019,048	0	0
Endocyte, Inc.	Common	29269A102	746	41,980	SH		SOLE		41,980	0	0
Epizyme, Inc.	Common	29428V104	5,144	485,325	SH		SOLE		485,325	0	0
Esperion Therapeutics, Inc.	Common	29664W105	8,399	189,287	SH		SOLE		189,287	0	0
Evolent Health, Inc.	Common	30050B101	2,394	84,300	SH		SOLE		84,300	0	0
Exelixis, Inc.	Common	30161Q104	9,816	553,940	SH		SOLE		553,940	0	0
Express Scripts Holding Company	Common	30219G108	5,059	53,250	SH		SOLE		53,250	0	0
FibroGen, Inc.	Common	31572Q808	10,826	178,207	SH		SOLE		178,207	0	0
Foamix Pharmaceuticals Ltd.	Shares	M46135105	4,167	727,205	SH		SOLE		727,205	0	0
Galapagos NV	Sponsored ADR	36315X101	11,222	99,815	SH		SOLE		99,815	0	0
Genomic Health, Inc.	Common	37244C101	2,439	34,740	SH		SOLE		34,740	0	0
Gilead Sciences, Inc.	Common	375558103	149,966	1,942,317	SH		SOLE		1,942,317	0	0
GlaxoSmithKline plc	Shares	37733W105	8,785	218,700	SH		SOLE		218,700	0	0
Global Blood Therapeutics, Inc.	Common	37890U108	5,026	132,270	SH		SOLE		132,270	0	0
Global Medical REIT Inc.	Common	37954A204	691	73,400	SH		SOLE		73,400	0	0
GW Pharmaceuticals plc	ADS	36197T103	7,531	43,598	SH		SOLE		43,598	0	0
HCA Healthcare, Inc.	Common	40412C101	10,341	74,335	SH		SOLE		74,335	0	0
HCP, Inc.	Common	40414L109	1,198	45,500	SH		SOLE		45,500	0	0
Healthcare Realty Trust Incorporated	Common	421946104	1,990	68,000	SH		SOLE		68,000	0	0
Healthcare Trust of America, Inc.	Common	42225P501	1,227	46,000	SH		SOLE		46,000	0	0
Henry Schein, Inc.	Common	806407102	2,670	31,400	SH		SOLE		31,400	0	0
Hologic, Inc.	Common	436440101	801	19,546	SH		SOLE		19,546	0	0
Horizon Pharma plc	Shares	G4617B105	3,190	162,900	SH		SOLE		162,900	0	0
Humana Inc.	Common	444859102	23,184	68,487	SH		SOLE		68,487	0	0
IDEXX Laboratories, Inc.	Common	45168D104	25,566	102,403	SH		SOLE		102,403	0	0
Illumina, Inc.	Common	452327109	89,092	242,717	SH		SOLE		242,717	0	0
ImmunoGen, Inc.	Common	45253H101	1,593	168,190	SH		SOLE		168,190	0	0
Immunomedics, Inc.	Common	452907108	2,028	97,370	SH		SOLE		97,370	0	0
Incyte Corporation	Common	45337C102	44,587	645,442	SH		SOLE		645,442	0	0
Innoviva, Inc.	Common	45781M101	2,463	161,603	SH		SOLE		161,603	0	0
Inovalon Holdings, Inc.	Common	45781D101	1,770	176,163	SH		SOLE		176,163	0	0
Intellia Therapeutics, Inc.	Common	45826J105	1,965	68,671	SH		SOLE		68,671	0	0
Intersect ENT, Inc.	Common	46071F103	240	8,356	SH		SOLE		8,356	0	0
Intra-Cellular Therapies, Inc.	Common	46116X101	756	34,850	SH		SOLE		34,850	0	0
Intuitive Surgical, Inc.	Common	46120E602	14,137	24,629	SH		SOLE		24,629	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	4,273	82,838	SH		SOLE		82,838	0	0
Iovance Biotherapeutics, Inc.	Common	462260100	2,440	216,908	SH		SOLE		216,908	0	0
IQVIA Holdings Inc.	Common	46266C105	2,180	16,800	SH		SOLE		16,800	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	18,570	110,452	SH		SOLE		110,452	0	0
Johnson & Johnson	Common	478160104	137,751	996,968	SH		SOLE		996,968	0	0
Jounce Therapeutics, Inc.	Common	481116101	66	10,127	SH		SOLE		10,127	0	0
Koninklijke Philips N.V.	NY Reg Sh	500472303	1,506	33,100	SH		SOLE		33,100	0	0
Laboratory Corporation of America Holdings	Sponsored ADR	50540R409	2,119	12,200	SH		SOLE		12,200	0	0
LeMaitre Vascular, Inc.	Common	525558201	1,052	27,150	SH		SOLE		27,150	0	0
Lexicon Pharmaceuticals, Inc.	Sponsored ADR	528872302	747	70,000	SH		SOLE		70,000	0	0
Ligand Pharmaceuticals Incorporated	Common	53220K504	2,454	8,940	SH		SOLE		8,940	0	0
LivaNova plc	Shares	G5509L101	779	6,287	SH		SOLE		6,287	0	0
Loxo Oncology, Inc.	Common	548862101	4,202	24,595	SH		SOLE		24,595	0	0
LTC Properties, Inc.	Common	502175102	9,249	209,673	SH		SOLE		209,673	0	0
Madrigal Pharmaceuticals, Inc.	Common	558868105	1,428	6,670	SH		SOLE		6,670	0	0
Mallinckrodt plc	Shares	G5785G107	1,571	53,600	SH		SOLE		53,600	0	0
Marinus Pharmaceuticals, Inc.	Common	56854Q101	3,362	336,228	SH		SOLE		336,228	0	0
Masimo Corporation	Common	574795100	4,237	34,020	SH		SOLE		34,020	0	0
McKesson Corporation	Common	58155Q103	11,003	82,947	SH		SOLE		82,947	0	0
Medical Properties Trust, Inc.	Common	58463J304	7,118	477,409	SH		SOLE		477,409	0	0
The Medicines Company	Common	584688105	4,960	165,841	SH		SOLE		165,841	0	0
Medtronic plc	Shares	G5960L103	33,391	339,439	SH		SOLE		339,439	0	0
Menlo Therapeutics Inc.	Common	586858102	244	24,784	SH		SOLE		24,784	0	0
Merck & Co., Inc.	Common	58933Y105	45,771	645,208	SH		SOLE		645,208	0	0
Merus N.V.	Common	N5749R100	8,175	414,115	SH		SOLE		414,115	0	0
Mettler-Toledo International Inc.	Common	592688105	2,131	3,500	SH		SOLE		3,500	0	0
Mirati Therapeutics, Inc.	Common	60468T105	640	13,590	SH		SOLE		13,590	0	0
Molecular Templates, Inc.	Common	608550109	777	144,110	SH		SOLE		144,110	0	0
Mylan N.V.	Shares	N59465109	60,647	1,657,017	SH		SOLE		1,657,017	0	0
MyoKardia, Inc.	Common	62857M105	2,517	38,600	SH		SOLE		38,600	0	0
Nektar Therapeutics	Common	640268108	12,952	212,469	SH		SOLE		212,469	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	26,143	212,630	SH		SOLE		212,630	0	0
Nevro Corp.	Common	64157F103	3,919	68,760	SH		SOLE		68,760	0	0
New Senior Investment Group Inc.	Common	648691103	3,121	528,919	SH		SOLE		528,919	0	0
NewLink Genetics Corporation	Common	651511107	490	205,026	SH		SOLE		205,026	0	0
Nightstar Therapeutics plc	ADR	65413A101	3,065	150,000	SH		SOLE		150,000	0	0
Novartis AG	Sponsored ADR	66987V109	27,803	322,690	SH		SOLE		322,690	0	0
Novavax, Inc.	Common	670002104	1,073	571,000	SH		SOLE		571,000	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	14,232	301,900	SH		SOLE		301,900	0	0
NuCana plc	Sponsored ADR	67022C106	245	9,823	SH		SOLE		9,823	0	0
NuVasive, Inc.	Common	670704105	1,390	19,580	SH		SOLE		19,580	0	0
Omega Healthcare Investors, Inc.	Common	681936100	19,000	579,785	SH		SOLE		579,785	0	0
Ovid Therapeutics Inc.	Common	690469101	3,038	535,824	SH		SOLE		535,824	0	0
Perrigo Company plc	Shares	G97822103	2,641	37,300	SH		SOLE		37,300	0	0
Pfizer Inc.	Common	717081103	59,675	1,354,093	SH		SOLE		1,354,093	0	0
Physicians Realty Trust	Common	71943U104	6,593	391,016	SH		SOLE		391,016	0	0
Pieris Pharmaceuticals, Inc.	Common	720795103	11,689	2,087,380	SH		SOLE		2,087,380	0	0
Portola Pharmaceuticals, Inc.	Sponsored ADR	737010108	3,074	115,448	SH		SOLE		115,448	0	0
PRA Health Sciences, Inc.	Common	69354M108	3,577	32,460	SH		SOLE		32,460	0	0
Protagonist Therapeutics, Inc.	Common	74366E102	2,254	219,042	SH		SOLE		219,042	0	0
PTC Therapeutics, Inc.	Common	69366J200	2,274	48,390	SH		SOLE		48,390	0	0
Puma Biotechnology, Inc.	Common	74587V107	3,821	83,340	SH		SOLE		83,340	0	0
Quest Diagnostics Incorporated	Common	74834L100	4,208	39,000	SH		SOLE		39,000	0	0
Quorum Health Corporation	Common	74909E106	139	23,725	SH		SOLE		23,725	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	59,086	146,237	SH		SOLE		146,237	0	0
Repligen Corporation	Common	759916109	2,146	38,700	SH		SOLE		38,700	0	0
ResMed Inc.	Common	761152107	6,762	58,630	SH		SOLE		58,630	0	0
Revance Therapeutics, Inc.	Common	761330109	1,936	77,919	SH		SOLE		77,919	0	0
Rhythm Pharmaceuticals, Inc.	Sponsored ADR	76243J105	726	24,890	SH		SOLE		24,890	0	0
The RMR Group Inc.	Class A	74967R106	494	5,323	SH		SOLE		5,323	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	16,753	724,606	SH		SOLE		724,606	0	0
Sage Therapeutics, Inc.	Common	78667J108	20,285	143,614	SH		SOLE		143,614	0	0
Sangamo Therapeutics, Inc.	Common	800677106	2,914	171,889	SH		SOLE		171,889	0	0
Sanofi	Sponsored ADR	80105N105	8,036	179,900	SH		SOLE		179,900	0	0
Sarepta Therapeutics, Inc.	Common	803607100	36,046	223,182	SH		SOLE		223,182	0	0
Seattle Genetics, Inc.	Common	812578102	21,549	279,417	SH		SOLE		279,417	0	0
Senior Housing Properties Trust	Common	81721M109	11,353	646,554	SH		SOLE		646,554	0	0
Shire plc	Shares	82481R106	6,565	36,216	SH		SOLE		36,216	0	0
Smith & Nephew plc	Sponsored ADR	83175M205	6,879	185,478	SH		SOLE		185,478	0	0
Spark Therapeutics, Inc.	Common	84652J103	1,203	22,046	SH		SOLE		22,046	0	0
SPDR S&P Biotech ETF	S&P Biotech ETF	78464A870	12,367	129,000	SH		SOLE		129,000	0	0
Spectrum Pharmaceuticals, Inc.	Common	84763A108	1,926	114,670	SH		SOLE		114,670	0	0
STERIS plc	Shares	G84720104	4,027	35,203	SH		SOLE		35,203	0	0
Stryker Corporation	Common	863667101	28,506	160,432	SH		SOLE		160,432	0	0
Sutro Biopharma, Inc.	Common	869367102	3,750	250,000	SH		SOLE		250,000	0	0
Syndax Pharmaceuticals, Inc.	Common	87164F105	1,616	200,000	SH		SOLE		200,000	0	0
Teleflex Incorporated	Common	879369106	1,697	6,379	SH		SOLE		6,379	0	0
Teligent, Inc.	Common	87960W104	401	101,458	SH		SOLE		101,458	0	0
Tenet Healthcare Corporation	Common	88033G407	4,682	164,500	SH		SOLE		164,500	0	0
TESARO, Inc.	Common	881569107	3,705	94,970	SH		SOLE		94,970	0	0
Tetraphase Pharmaceuticals, Inc.	Common	88165N105	2,372	859,322	SH		SOLE		859,322	0	0
Teva Pharmaceutical Industries Limited	Sponsored ADR	881624209	20,096	932,948	SH		SOLE		932,948	0	0
Theravance Biopharma, Inc.	Common	G8807B106	264	8,083	SH		SOLE		8,083	0	0
Thermo Fisher Scientific Inc.	Common	883556102	44,031	180,395	SH		SOLE		180,395	0	0
Trillium Therapeutics Inc.	Common	89620X506	2,717	468,399	SH		SOLE		468,399	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	5,875	76,958	SH		SOLE		76,958	0	0
uniQure N.V.	Shares	N90064101	1,373	37,741	SH		SOLE		37,741	0	0
United Therapeutics Corporation	Class B	91307C102	5,276	41,261	SH		SOLE		41,261	0	0
Unitedhealth Group Incorporated	Common	91324P102	91,647	344,486	SH		SOLE		344,486	0	0
Varian Medical Systems, Inc.	Common	92220P105	2,936	26,227	SH		SOLE		26,227	0	0
Ventas, Inc.	Common	92276F100	5,356	98,496	SH		SOLE		98,496	0	0
Verona Pharma plc	Sponsored ADR	925050106	3,440	275,000	SH		SOLE		275,000	0	0
Vertex Pharmaceuticals Incorporated	Common	92532F100	78,683	408,235	SH		SOLE		408,235	0	0
Waters Corporation	Common	941848103	2,103	10,800	SH		SOLE		10,800	0	0
Welltower Inc.	Common	95040Q104	2,930	45,560	SH		SOLE		45,560	0	0
Wright Medical Group N.V.	Ordinary Shares	N96617118	7,742	266,781	SH		SOLE		266,781	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	15,625	118,846	SH		SOLE		118,846	0	0
Zoetis Inc.	Class A	98978V103	20,822	227,415	SH		SOLE		227,415	0	0
Zogenix, Inc.	Common	98978L204	3,283	66,182	SH		SOLE		66,182	0	0