Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Abbott Laboratories	Common	002824100	36,536	457,048	SH		SOLE		457,048	0	0
AbbVie Inc.	Common	00287Y109	25,806	320,213	SH		SOLE		320,213	0	0
ABIOMED, Inc.	Common	003654100	6,850	23,986	SH		SOLE		23,986	0	0
AC Immune SA	Shares	H00263105	868	171,813	SH		SOLE		171,813	0	0
Acadia Healthcare Company, Inc.	Common	00404A109	5,075	173,155	SH		SOLE		173,155	0	0
ACADIA Pharmaceuticals Inc.	Common	004225108	2,812	104,714	SH		SOLE		104,714	0	0
Acceleron Pharma Inc.	Common	00434H108	8,773	188,388	SH		SOLE		188,388	0	0
Adaptimmune Therapeutics plc	Sponsored ADR	00653A107	983	228,496	SH		SOLE		228,496	0	0
Aerie Pharmaceuticals, Inc.	Common	00771V108	3,254	68,496	SH		SOLE		68,496	0	0
Aerpio Pharmaceuticals, Inc.	Common	00810B105	667	740,000	SH		SOLE		740,000	0	0
Affimed N.V.	Common	N01045108	1,067	254,000	SH		SOLE		254,000	0	0
Agios Pharmaceuticals, Inc.	Common	00847X104	6,189	91,776	SH		SOLE		91,776	0	0
Akebia Therapeutics, Inc.	Common	00972D105	1,752	213,942	SH		SOLE		213,942	0	0
Albireo Pharma, Inc.	Common	01345P106	4,026	125,000	SH		SOLE		125,000	0	0
Alexion Pharmaceuticals, Inc.	Common	015351109	50,788	375,705	SH		SOLE		375,705	0	0
Align Technology, Inc.	Common	016255101	8,040	28,278	SH		SOLE		28,278	0	0
Alkermes plc	Shares	G01767105	7,227	198,048	SH		SOLE		198,048	0	0
Allakos Inc.	Common	01671P100	989	24,414	SH		SOLE		24,414	0	0
Allergan plc	Shares	G0177J108	28,296	193,263	SH		SOLE		193,263	0	0
Alliqua BioMedical, Inc.	Common	019621309	437	148,500	SH		SOLE		148,500	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	12,472	133,458	SH		SOLE		133,458	0	0
Amarin Corporation plc	Sponsored ADR	023111206	12,692	611,352	SH		SOLE		611,352	0	0
AmerisourceBergen Corporation	Common	03073E105	6,300	79,226	SH		SOLE		79,226	0	0
Amgen Inc.	Common	031162100	133,819	704,383	SH		SOLE		704,383	0	0
Amicus Therapeutics, Inc.	Common	03152W109	4,279	314,597	SH		SOLE		314,597	0	0
AnaptysBio, Inc.	Common	032724106	4,810	65,845	SH		SOLE		65,845	0	0
Anthem, Inc.	Common	036752103	40,567	141,358	SH		SOLE		141,358	0	0
ARCA biopharma, Inc.	Common	00211Y407	303	811,227	SH		SOLE		811,227	0	0
Ardelyx, Inc.	Common	039697107	1,790	639,370	SH		SOLE		639,370	0	0
Arena Pharmaceuticals, Inc.	Common	040047607	2,343	52,262	SH		SOLE		52,262	0	0
argenx SE	Sponsored ADR	04016X101	3,543	28,381	SH		SOLE		28,381	0	0
ArQule, Inc.	Common	04269E107	1,198	250,000	SH		SOLE		250,000	0	0
Array BioPharma Inc.	Common	04269X105	8,878	364,166	SH		SOLE		364,166	0	0
Arrowhead Pharmaceuticals, Inc.	Common	04280A100	563	30,700	SH		SOLE		30,700	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	7,222	61,360	SH		SOLE		61,360	0	0
AstraZeneca PLC	Sponsored ADR	046353108	14,595	360,998	SH		SOLE		360,998	0	0
Athenex, Inc.	Common	04685N103	558	45,530	SH		SOLE		45,530	0	0
Audentes Therapeutics, Inc.	Common	05070R104	2,051	52,574	SH		SOLE		52,574	0	0
Avadel Pharmaceuticals plc	Sponsored ADR	05337M104	1,173	814,588	SH		SOLE		814,588	0	0
Bausch Health Companies Inc.	Common	071734107	4,170	168,812	SH		SOLE		168,812	0	0
Baxter International Inc.	Common	071813109	11,194	137,668	SH		SOLE		137,668	0	0
Becton, Dickinson and Company	Common	075887109	15,414	61,721	SH		SOLE		61,721	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	12,525	94,889	SH		SOLE		94,889	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481107	202	60,000	SH		SOLE		60,000	0	0
Bio-Techne Corporation	Common	09073M104	4,309	21,701	SH		SOLE		21,701	0	0
Biogen Inc.	Common	09062X103	74,289	314,278	SH		SOLE		314,278	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	19,728	222,086	SH		SOLE		222,086	0	0
bluebird bio, Inc.	Common	09609G100	14,322	91,029	SH		SOLE		91,029	0	0
Blueprint Medicines Corporation	Common	09627Y109	9,263	115,720	SH		SOLE		115,720	0	0
Boston Scientific Corporation	Common	101137107	18,177	473,619	SH		SOLE		473,619	0	0
Bristol-Myers Squibb Company	Common	110122108	35,212	738,044	SH		SOLE		738,044	0	0
Cardinal Health, Inc.	Common	14149Y108	303	6,300	SH		SOLE		6,300	0	0
Celgene Corporation	Common	151020104	139,030	1,473,710	SH		SOLE		1,473,710	0	0
Celldex Therapeutics, Inc.	Common	15117B202	35	7,053	SH		SOLE		7,053	0	0
Cellectis SA	Sponsored ADR	15117K103	3,173	173,035	SH		SOLE		173,035	0	0
Centene Corporation	Common	15135B101	6,812	128,295	SH		SOLE		128,295	0	0
Charles River Laboratories International, Inc.	Common	159864107	1,545	10,640	SH		SOLE		10,640	0	0
Cidara Therapeutics, Inc.	Common	171757107	421	158,784	SH		SOLE		158,784	0	0
Cigna Corporation	Common	125523100	18,777	116,756	SH		SOLE		116,756	0	0
Clearside Biomedical, Inc.	Common	185063104	228	165,330	SH		SOLE		165,330	0	0
Clovis Oncology, Inc.	Common	189464100	1,871	75,400	SH		SOLE		75,400	0	0
Coherus Biosciences, Inc.	Common	19249H103	4,299	315,162	SH		SOLE		315,162	0	0
Community Health Systems, Inc.	Common	203668108	761	203,935	SH		SOLE		203,935	0	0
Concert Pharmaceuticals, Inc.	Common	206022105	548	45,362	SH		SOLE		45,362	0	0
CRISPR Therapeutics AG	Namen AKT	H17182108	6,371	178,348	SH		SOLE		178,348	0	0
CVS Health Corporation	Common	126650100	27,308	506,364	SH		SOLE		506,364	0	0
Danaher Corporation	Common	235851102	20,982	158,931	SH		SOLE		158,931	0	0
Denali Therapeutics Inc.	Common	24823R105	450	19,372	SH		SOLE		19,372	0	0
DENTSPLY SIRONA Inc.	Common	24906P109	7,762	156,521	SH		SOLE		156,521	0	0
Diplomat Pharmacy, Inc.	Common	25456K101	1,248	214,845	SH		SOLE		214,845	0	0
Dr. Reddy's Laboratories Ltd.	Sponsored ADR	256135203	1,172	28,950	SH		SOLE		28,950	0	0
Editas Medicine, Inc.	Common	28106W103	1,875	76,668	SH		SOLE		76,668	0	0
Edwards Lifesciences Corporation	Common	28176E108	10,867	56,798	SH		SOLE		56,798	0	0
Eli Lilly and Company	Common	532457108	38,321	295,320	SH		SOLE		295,320	0	0
Endo International plc	Shares	G30401106	4,269	531,570	SH		SOLE		531,570	0	0
Epizyme, Inc.	Common	29428V104	3,586	289,404	SH		SOLE		289,404	0	0
Esperion Therapeutics, Inc.	Common	29664W105	7,412	184,607	SH		SOLE		184,607	0	0
Evolent Health, Inc.	Common	30050B101	530	42,150	SH		SOLE		42,150	0	0
Exelixis, Inc.	Common	30161Q104	16,148	678,467	SH		SOLE		678,467	0	0
FibroGen, Inc.	Common	31572Q808	9,552	175,742	SH		SOLE		175,742	0	0
Foamix Pharmaceuticals Ltd	Shares	M46135105	1,128	300,781	SH		SOLE		300,781	0	0
Galapagos NV	Sponsored ADR	36315X101	5,715	48,525	SH		SOLE		48,525	0	0
Genomic Health, Inc.	Common	37244C101	1,858	26,531	SH		SOLE		26,531	0	0
Gilead Sciences, Inc.	Common	375558103	113,728	1,749,388	SH		SOLE		1,749,388	0	0
GlaxoSmithKline plc	Shares	37733W105	9,139	218,700	SH		SOLE		218,700	0	0
Global Blood Therapeutics, Inc.	Common	37890U108	4,551	85,988	SH		SOLE		85,988	0	0
Global Medical REIT Inc.	Common	37954A204	721	73,400	SH		SOLE		73,400	0	0
GW Pharmaceuticals plc	ADS	36197T103	5,882	34,891	SH		SOLE		34,891	0	0
HCA Healthcare, Inc.	Common	40412C101	11,678	89,569	SH		SOLE		89,569	0	0
HCP, Inc.	Common	40414L109	1,424	45,500	SH		SOLE		45,500	0	0
Healthcare Realty Trust Incorporated	Common	421946104	2,183	68,000	SH		SOLE		68,000	0	0
Healthcare Trust of America, Inc.	Common	42225P501	1,315	46,000	SH		SOLE		46,000	0	0
Hologic, Inc.	Common	436440101	946	19,546	SH		SOLE		19,546	0	0
Horizon Pharma plc	Shares	G4617B105	511	19,350	SH		SOLE		19,350	0	0
Humana Inc.	Common	444859102	9,491	35,682	SH		SOLE		35,682	0	0
IDEXX Laboratories, Inc.	Common	45168D104	14,233	63,654	SH		SOLE		63,654	0	0
Illumina, Inc.	Common	452327109	73,793	237,514	SH		SOLE		237,514	0	0
ImmunoGen, Inc.	Common	45253H101	456	168,190	SH		SOLE		168,190	0	0
Immunomedics, Inc.	Common	452907108	5,526	287,687	SH		SOLE		287,687	0	0
Incyte Corporation	Common	45337C102	45,511	529,133	SH		SOLE		529,133	0	0
Inogen, Inc.	Common	45780L104	763	8,000	SH		SOLE		8,000	0	0
Intellia Therapeutics, Inc.	Common	45826J105	2,567	150,290	SH		SOLE		150,290	0	0
Intercept Pharmaceuticals, Inc.	Common	45845P108	6,631	59,275	SH		SOLE		59,275	0	0
Intra-Cellular Therapies, Inc.	Common	46116X101	1,342	110,193	SH		SOLE		110,193	0	0
Intuitive Surgical, Inc.	Common	46120E602	22,984	40,281	SH		SOLE		40,281	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	8,906	109,720	SH		SOLE		109,720	0	0
Iovance Biotherapeutics, Inc.	Common	462260100	2,063	216,908	SH		SOLE		216,908	0	0
IQVIA Holdings Inc.	Common	46266C105	2,358	16,391	SH		SOLE		16,391	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	9,645	67,471	SH		SOLE		67,471	0	0
Johnson & Johnson	Common	478160104	125,530	897,990	SH		SOLE		897,990	0	0
Jounce Therapeutics, Inc.	Common	481116101	63	10,127	SH		SOLE		10,127	0	0
Koninklijke Philips N.V.	NY Reg Sh	500472303	3,489	85,400	SH		SOLE		85,400	0	0
Laboratory Corporation of America Holdings	Sponsored ADR	50540R409	6,985	45,657	SH		SOLE		45,657	0	0
Ligand Pharmaceuticals, Inc.	Common	53220K504	3,758	29,895	SH		SOLE		29,895	0	0
LivaNova PLC	Shares	G5509L101	1,109	11,400	SH		SOLE		11,400	0	0
LTC Properties, Inc.	Common	502175102	6,660	145,421	SH		SOLE		145,421	0	0
Madrigal Pharmaceuticals, Inc.	Common	558868105	1,671	13,340	SH		SOLE		13,340	0	0
Mallinckrodt public limited company	Sponsored ADR	G5785G107	717	32,980	SH		SOLE		32,980	0	0
Marinus Pharmaceuticals, Inc.	Common	56854Q101	1,373	328,436	SH		SOLE		328,436	0	0
Masimo Corporation	Common	574795100	1,482	10,715	SH		SOLE		10,715	0	0
McKesson Corporation	Common	58155Q103	8,278	70,720	SH		SOLE		70,720	0	0
Medical Properties Trust, Inc.	Common	58463J304	6,035	326,063	SH		SOLE		326,063	0	0
The Medicines Company	Common	584688105	8,200	293,392	SH		SOLE		293,392	0	0
Medtronic plc	Shares	G5960L103	44,812	492,002	SH		SOLE		492,002	0	0
Merck & Co., Inc.	Common	58933Y105	82,595	993,083	SH		SOLE		993,083	0	0
Merus N.V.	Common	N5749R100	4,692	317,671	SH		SOLE		317,671	0	0
Mirati Therapeutics, Inc.	Common	60468T105	996	13,590	SH		SOLE		13,590	0	0
Molecular Templates, Inc.	Common	608550109	837	144,110	SH		SOLE		144,110	0	0
Mylan N.V.	Shares	N59465109	26,729	943,152	SH		SOLE		943,152	0	0
MyoKardia, Inc.	Common	62857M105	2,007	38,600	SH		SOLE		38,600	0	0
Myriad Genetics, Inc.	Common	62855J104	682	20,549	SH		SOLE		20,549	0	0
Nektar Therapeutics	Common	640268108	9,532	283,679	SH		SOLE		283,679	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	19,530	221,678	SH		SOLE		221,678	0	0
New Senior Investment Group Inc.	Common	648691103	1,437	263,647	SH		SOLE		263,647	0	0
Novartis AG	Sponsored ADR	66987V109	26,616	276,847	SH		SOLE		276,847	0	0
Novavax, Inc.	Common	670002104	315	571,000	SH		SOLE		571,000	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	13,161	251,600	SH		SOLE		251,600	0	0
Novocure Limited	Ordinary Shares	G6674U108	3,177	65,964	SH		SOLE		65,964	0	0
NuVasive, Inc.	Common	670704105	217	3,816	SH		SOLE		3,816	0	0
Omega Healthcare Investors, Inc.	Common	681936100	12,981	340,266	SH		SOLE		340,266	0	0
Ovid Therapeutics Inc.	Sponsored ADR	690469101	880	496,977	SH		SOLE		496,977	0	0
Perrigo Company plc	Shares	G97822103	1,046	21,718	SH		SOLE		21,718	0	0
Pfizer Inc.	Common	717081103	87,945	2,070,765	SH		SOLE		2,070,765	0	0
Physicians Realty Trust	Common	71943U104	5,717	303,908	SH		SOLE		303,908	0	0
Pieris Pharmaceuticals, Inc.	Common	720795103	6,993	2,087,380	SH		SOLE		2,087,380	0	0
Portola Pharmaceuticals, Inc.	Sponsored ADR	737010108	4,006	115,448	SH		SOLE		115,448	0	0
PRA Health Sciences, Inc.	Common	69354M108	15,831	143,537	SH		SOLE		143,537	0	0
Protagonist Therapeutics, Inc.	Common	74366E102	2,230	177,425	SH		SOLE		177,425	0	0
PTC Therapeutics, Inc.	Common	69366J200	2,584	68,652	SH		SOLE		68,652	0	0
Puma Biotechnology, Inc.	Common	74587V107	2,767	71,340	SH		SOLE		71,340	0	0
Quest Diagnostics, Inc.	Common	74834L100	5,980	66,500	SH		SOLE		66,500	0	0
Quorum Health Corporation	Common	74909E106	33	23,725	SH		SOLE		23,725	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	58,116	141,532	SH		SOLE		141,532	0	0
ResMed Inc.	Common	761152107	7,171	68,974	SH		SOLE		68,974	0	0
Rhythm Pharmaceuticals, Inc.	Common	76243J105	682	24,890	SH		SOLE		24,890	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	9,078	466,247	SH		SOLE		466,247	0	0
Sage Therapeutics, Inc.	Common	78667J108	12,701	79,856	SH		SOLE		79,856	0	0
Sangamo Therapeutics, Inc.	Common	800677106	2,304	241,538	SH		SOLE		241,538	0	0
Sanofi	Sponsored ADR	80105N105	7,966	179,900	SH		SOLE		179,900	0	0
Sarepta Therapeutics, Inc.	Common	803607100	17,622	147,847	SH		SOLE		147,847	0	0
Seattle Genetics, Inc.	Common	812578102	21,234	289,925	SH		SOLE		289,925	0	0
Senior Housing Properties Trust	Common	81721M109	4,214	357,720	SH		SOLE		357,720	0	0
Smith & Nephew plc	Shares	83175M205	7,440	185,478	SH		SOLE		185,478	0	0
SPDR S&P Biotech ETF	S&P Biotech ETF	78464A870	8,060	89,022	SH		SOLE		89,022	0	0
Spectrum Pharmaceuticals, Inc.	Common	84763A108	1,226	114,670	SH		SOLE		114,670	0	0
STERIS plc	Shares	G8473T100	6,146	48,003	SH		SOLE		48,003	0	0
Stryker Corporation	Common	863667101	24,305	123,050	SH		SOLE		123,050	0	0
Sutro Biopharma, Inc.	Common	869367102	7,304	641,268	SH		SOLE		641,268	0	0
Syndax Pharmaceuticals, Inc.	Common	87164F105	753	143,438	SH		SOLE		143,438	0	0
Syneos Health, Inc.	Class A	87166B102	1,502	29,027	SH		SOLE		29,027	0	0
Takeda Pharmaceutical Company Limited	Sponsored ADS	874060205	3,628	178,128	SH		SOLE		178,128	0	0
Teleflex Incorporated	Common	879369106	1,927	6,379	SH		SOLE		6,379	0	0
Tenet Healthcare Corporation	Common	88033G407	4,070	141,136	SH		SOLE		141,136	0	0
Tetraphase Pharmaceuticals, Inc.	Common	88165N105	1,151	859,322	SH		SOLE		859,322	0	0
Teva Pharmaceutical Industries Limited	Sponsored ADR	881624209	13,971	890,989	SH		SOLE		890,989	0	0
Thermo Fisher Scientific Inc.	Common	883556102	39,072	142,743	SH		SOLE		142,743	0	0
Trillium Therapeutics Inc.	Common	89620X506	294	446,099	SH		SOLE		446,099	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	5,338	76,958	SH		SOLE		76,958	0	0
uniQure N.V.	Shares	N90064101	1,178	19,751	SH		SOLE		19,751	0	0
United Therapeutics Corporation	Class B	91307C102	4,843	41,261	SH		SOLE		41,261	0	0
Unitedhealth Group Incorporated	Common	91324P102	80,145	324,133	SH		SOLE		324,133	0	0
Varian Medical Systems, Inc.	Common	92220P105	3,717	26,227	SH		SOLE		26,227	0	0
Ventas, Inc.	Common	92276F100	6,285	98,496	SH		SOLE		98,496	0	0
Verona Pharma plc	Sponsored ADR	925050106	1,719	275,000	SH		SOLE		275,000	0	0
Vertex Pharmaceuticals Incorporated	Common	92532F100	81,621	443,712	SH		SOLE		443,712	0	0
Viking Therapeutics, Inc.	Common	92686J106	1,133	114,016	SH		SOLE		114,016	0	0
WaVe Life Sciences Ltd.	Shares	Y95308105	1,179	30,336	SH		SOLE		30,336	0	0
WellCare Health Plans, Inc.	Common	94946T106	5,202	19,286	SH		SOLE		19,286	0	0
Welltower Inc.	Common	95040Q104	18,416	237,322	SH		SOLE		237,322	0	0
Wright Medical Group N.V.	Ordinary Shares	N96617118	3,610	114,776	SH		SOLE		114,776	0	0
Xencor, Inc.	Common	98401F105	2,248	72,382	SH		SOLE		72,382	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	10,172	79,654	SH		SOLE		79,654	0	0
Zoetis Inc.	Class A	98978V103	25,872	257,001	SH		SOLE		257,001	0	0
Zogenix, Inc.	Common	98978L204	4,938	89,762	SH		SOLE		89,762	0	0