Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
Abbott Laboratories	Common	002824100	40,221	369,573	SH		SOLE		369,573	0	0
AbbVie Inc.	Common	00287Y109	76,617	874,720	SH		SOLE		874,720	0	0
ABIOMED, Inc.	Common	003654100	3,383	12,212	SH		SOLE		12,212	0	0
AC Immune SA	Shares	H00263105	838	171,813	SH		SOLE		171,813	0	0
Acadia Healthcare Co., Inc.	Common	00404A109	3,868	131,200	SH		SOLE		131,200	0	0
ACADIA Pharmaceuticals Inc.	Common	004225108	10,343	250,743	SH		SOLE		250,743	0	0
Adaptive Biotechnologies Corp.	Common	00650F109	1,202	24,715	SH		SOLE		24,715	0	0
Addus HomeCare Corp.	Common	006739106	1,509	15,969	SH		SOLE		15,969	0	0
Aerie Pharmaceuticals, Inc.	Common	00771V108	785	66,688	SH		SOLE		66,688	0	0
Agilent Technologies, Inc.	Common	00846U101	5,302	52,525	SH		SOLE		52,525	0	0
Agios Pharmaceuticals, Inc.	Common	00847X104	6,544	186,964	SH		SOLE		186,964	0	0
Alcon Inc.	Ordinary Shares	H01301128	2,089	36,686	SH		SOLE		36,686	0	0
Alexion Pharmaceuticals, Inc.	Common	015351109	30,529	266,791	SH		SOLE		266,791	0	0
Align Technology, Inc.	Common	016255101	3,287	10,041	SH		SOLE		10,041	0	0
Alkermes plc	Shares	G01767105	2,816	169,930	SH		SOLE		169,930	0	0
Allakos Inc.	Common	01671P100	5,245	64,397	SH		SOLE		64,397	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	25,465	174,894	SH		SOLE		174,894	0	0
Amarin Corp. plc	Sponsored ADR	023111206	3,577	849,588	SH		SOLE		849,588	0	0
Amedisys, Inc.	Common	023436108	4,586	19,395	SH		SOLE		19,395	0	0
AmerisourceBergen Corp.	Common	03073E105	7,816	80,645	SH		SOLE		80,645	0	0
Amgen Inc.	Common	031162100	154,585	608,218	SH		SOLE		608,218	0	0
Amicus Therapeutics, Inc.	Common	03152W109	5,727	405,626	SH		SOLE		405,626	0	0
Anthem, Inc.	Common	036752103	9,974	37,133	SH		SOLE		37,133	0	0
Apellis Pharmaceuticals, Inc.	Common	03753U106	6,517	216,017	SH		SOLE		216,017	0	0
ARCA biopharma, Inc.	Common	00211Y506	143	32,461	SH		SOLE		32,461	0	0
Ardelyx, Inc.	Common	039697107	3,190	607,698	SH		SOLE		607,698	0	0
Arena Pharmaceuticals, Inc.	Common	040047607	12,014	160,637	SH		SOLE		160,637	0	0
argenx SE	Sponsored ADR	04016X101	16,194	61,687	SH		SOLE		61,687	0	0
Arrowhead Pharmaceuticals, Inc.	Common	04280A100	3,194	74,186	SH		SOLE		74,186	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	19,405	125,746	SH		SOLE		125,746	0	0
Assertio Holdings, Inc.	Common	04546C106	1,093	1,642,302	SH		SOLE		1,642,302	0	0
AstraZeneca PLC	Sponsored ADR	046353108	18,869	344,333	SH		SOLE		344,333	0	0
Atreca, Inc.	Class A Common	04965G109	4,923	352,424	SH		SOLE		352,424	0	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	4,428	300,611	SH		SOLE		300,611	0	0
Avadel Pharmaceuticals plc	Sponsored ADR	05337M104	1,177	233,612	SH		SOLE		233,612	0	0
Axonics Modulation Technologies, Inc.	Common	05465P101	990	19,400	SH		SOLE		19,400	0	0
Axsome Therapeutics, Inc.	Common	05464T104	2,251	31,591	SH		SOLE		31,591	0	0
Bausch Health Companies Inc.	Common	071734107	1,840	118,412	SH		SOLE		118,412	0	0
Baxter International Inc.	Common	071813109	9,813	122,023	SH		SOLE		122,023	0	0
Becton, Dickinson and Co.	Common	075887109	30,649	131,723	SH		SOLE		131,723	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	8,101	28,280	SH		SOLE		28,280	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481404	39	6,000	SH		SOLE		6,000	0	0
Bio-Techne Corp.	Common	09073M104	12,810	51,710	SH		SOLE		51,710	0	0
Biogen Inc.	Common	09062X103	60,637	213,753	SH		SOLE		213,753	0	0
Biohaven Pharmaceutical Holding Co. Ltd.	Common	G11196105	2,228	34,277	SH		SOLE		34,277	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	24,789	325,822	SH		SOLE		325,822	0	0
BioNTech SE	Sponsored ADS	09075V102	3,018	43,595	SH		SOLE		43,595	0	0
bluebird bio, Inc.	Common	09609G100	4,542	84,194	SH		SOLE		84,194	0	0
Blueprint Medicines Corp.	Common	09627Y109	15,761	170,018	SH		SOLE		170,018	0	0
Boston Scientific Corp.	Common	101137107	28,325	741,296	SH		SOLE		741,296	0	0
Bristol Myers Squibb Co.	Common	110122108	56,982	945,140	SH		SOLE		945,140	0	0
Bristol Myers Squibb Co.	Right	110122157	3,316	1,473,710	SH		SOLE		1,473,710	0	0
Celldex Therapeutics, Inc.	Common	15117B202	105	7,053	SH		SOLE		7,053	0	0
Cellectis S.A.	Sponsored ADR	15117K103	2,038	110,147	SH		SOLE		110,147	0	0
Centene Corp.	Common	15135B101	26,733	458,313	SH		SOLE		458,313	0	0
Cerner Corp.	Common	156782104	5,892	81,500	SH		SOLE		81,500	0	0
Charles River Laboratories International, Inc.	Common	159864107	6,964	30,754	SH		SOLE		30,754	0	0
ChemoCentryx, Inc.	Common	16383L106	7,916	144,447	SH		SOLE		144,447	0	0
Cigna Corp.	Common	125523100	12,069	71,241	SH		SOLE		71,241	0	0
Clearside Biomedical, Inc.	Common	185063104	255	165,330	SH		SOLE		165,330	0	0
Cogent Biosciences, Inc.	Common	19240Q102	2,581	1,103,175	SH		SOLE		1,103,175	0	0
Coherus Biosciences, Inc.	Common	19249H103	3,725	203,103	SH		SOLE		203,103	0	0
Community Health Systems, Inc.	Common	203668108	497	117,735	SH		SOLE		117,735	0	0
Community Healthcare Trust Inc.	Common	20369C106	697	14,900	SH		SOLE		14,900	0	0
Corbus Pharmaceuticals Holdings, Inc.	Common	21833P103	744	413,481	SH		SOLE		413,481	0	0
CRISPR Therapeutics AG	Namen AKT	H17182108	6,375	76,222	SH		SOLE		76,222	0	0
CVS Health Corp.	Common	126650100	22,675	388,263	SH		SOLE		388,263	0	0
CymaBay Therapeutics, Inc.	Common	23257D103	638	88,102	SH		SOLE		88,102	0	0
Danaher Corp.	Common	235851102	14,549	67,567	SH		SOLE		67,567	0	0
Deciphera Pharmaceuticals, Inc.	Common	24344T101	3,148	61,370	SH		SOLE		61,370	0	0
DENTSPLY SIRONA Inc.	Common	24906P109	17,863	408,473	SH		SOLE		408,473	0	0
DexCom, Inc.	Common	252131107	7,644	18,544	SH		SOLE		18,544	0	0
Dicerna Pharmaceuticals, Inc.	Common	253031108	1,226	68,150	SH		SOLE		68,150	0	0
Diversified Healthcare Trust	Common	25525P107	1,259	357,720	SH		SOLE		357,720	0	0
Edwards Lifesciences Corp.	Common	28176E108	23,240	291,155	SH		SOLE		291,155	0	0
Eidos Therapeutics, Inc.	Common	28249H104	1,011	20,000	SH		SOLE		20,000	0	0
Eli Lilly and Co.	Common	532457108	26,294	177,637	SH		SOLE		177,637	0	0
Endo International plc	Shares	G30401106	1,754	531,570	SH		SOLE		531,570	0	0
Esperion Therapeutics, Inc.	Common	29664W105	1,545	41,577	SH		SOLE		41,577	0	0
Exact Sciences Corp.	Common	30063P105	1,545	15,150	SH		SOLE		15,150	0	0
Exelixis, Inc.	Common	30161Q104	26,776	1,095,117	SH		SOLE		1,095,117	0	0
Fate Therapeutics, Inc.	Common	31189P102	8,692	217,462	SH		SOLE		217,462	0	0
FibroGen, Inc.	Common	31572Q808	7,988	194,270	SH		SOLE		194,270	0	0
Five Star Senior Living Inc.	Common	33832D205	123	24,237	SH		SOLE		24,237	0	0
Galapagos NV	Sponsored ADR	36315X101	929	6,543	SH		SOLE		6,543	0	0
Galera Therapeutics, Inc.	Common	36338D108	9,418	1,041,845	SH		SOLE		1,041,845	0	0
Genmab A/S	Sponsored ADS	372303206	6,765	184,779	SH		SOLE		184,779	0	0
Gilead Sciences, Inc.	Common	375558103	103,864	1,643,683	SH		SOLE		1,643,683	0	0
GlaxoSmithKline PLC	Shares	37733W105	1,220	32,400	SH		SOLE		32,400	0	0
Global Blood Therapeutics, Inc.	Common	37890U108	3,957	71,759	SH		SOLE		71,759	0	0
Global Medical REIT Inc.	Common	37954A204	2,361	174,897	SH		SOLE		174,897	0	0
Grifols, S.A.	Sponsored ADR	398438408	822	47,373	SH		SOLE		47,373	0	0
Guardant Health, Inc.	Common	40131M109	13,173	117,852	SH		SOLE		117,852	0	0
Harpoon Therapeutics, Inc.	Common	41358P106	1,808	106,419	SH		SOLE		106,419	0	0
HCA Healthcare, Inc.	Common	40412C101	10,215	81,933	SH		SOLE		81,933	0	0
Health Care Select Sector SPDR Fund	SBI Healthcare	81369Y209	1,061	10,055	SH		SOLE		10,055	0	0
Healthcare Realty Trust Inc.	Common	421946104	3,133	104,024	SH		SOLE		104,024	0	0
Healthcare Trust of America, Inc.	Common	42225P501	1,837	70,662	SH		SOLE		70,662	0	0
Healthpeak Properties, Inc.	Common	42250P103	4,083	150,392	SH		SOLE		150,392	0	0
Heron Therapeutics, Inc.	Common	427746102	1,944	131,183	SH		SOLE		131,183	0	0
Hologic, Inc.	Common	436440101	2,165	32,564	SH		SOLE		32,564	0	0
Horizon Therapeutics plc	Shares	G46188101	46,894	603,684	SH		SOLE		603,684	0	0
Humana Inc.	Common	444859102	35,597	86,007	SH		SOLE		86,007	0	0
IDEXX Laboratories, Inc.	Common	45168D104	13,686	34,814	SH		SOLE		34,814	0	0
Illumina, Inc.	Common	452327109	86,868	281,054	SH		SOLE		281,054	0	0
ImmunoGen, Inc.	Common	45253H101	605	168,190	SH		SOLE		168,190	0	0
Immunomedics, Inc.	Common	452907108	18,990	223,336	SH		SOLE		223,336	0	0
Incyte Corp.	Common	45337C102	13,695	152,605	SH		SOLE		152,605	0	0
Inogen, Inc.	Common	45780L104	1,491	51,406	SH		SOLE		51,406	0	0
Insmed Inc.	Common	457669307	3,162	98,387	SH		SOLE		98,387	0	0
Intercept Pharmaceuticals, Inc.	Common	45845P108	3,195	77,067	SH		SOLE		77,067	0	0
Intra-Cellular Therapies, Inc.	Common	46116X101	2,418	94,238	SH		SOLE		94,238	0	0
Intuitive Surgical, Inc.	Common	46120E602	17,787	25,069	SH		SOLE		25,069	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	9,167	193,201	SH		SOLE		193,201	0	0
Iovance Biotherapeutics, Inc.	Common	462260100	8,924	271,073	SH		SOLE		271,073	0	0
IQVIA Holdings Inc.	Common	46266C105	12,968	82,266	SH		SOLE		82,266	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	9,619	67,456	SH		SOLE		67,456	0	0
Johnson & Johnson	Common	478160104	81,408	546,805	SH		SOLE		546,805	0	0
Kadmon Holdings, Inc.	Common	48283N106	2,799	714,008	SH		SOLE		714,008	0	0
Karuna Therapeutics, Inc.	Common	48576A100	3,234	41,827	SH		SOLE		41,827	0	0
Karyopharm Therapeutics Inc.	Common	48576U106	960	65,743	SH		SOLE		65,743	0	0
Koninklijke Philips N.V.	NY Reg Sh	500472303	2,684	56,927	SH		SOLE		56,927	0	0
Kura Oncology, Inc.	Common	50127T109	1,818	59,339	SH		SOLE		59,339	0	0
Laboratory Corporation of America Holdings	Sponsored ADR	50540R409	13,179	70,003	SH		SOLE		70,003	0	0
LTC Properties, Inc.	Common	502175102	6,355	182,293	SH		SOLE		182,293	0	0
Madrigal Pharmaceuticals, Inc.	Common	558868105	1,584	13,340	SH		SOLE		13,340	0	0
Magenta Therapeutics, Inc.	Common	55910K108	1,309	192,431	SH		SOLE		192,431	0	0
Mallinckrodt plc	Sponsored ADR	G5785G107	32	32,980	SH		SOLE		32,980	0	0
McKesson Corp.	Common	58155Q103	16,015	107,537	SH		SOLE		107,537	0	0
Medical Properties Trust, Inc.	Common	58463J304	7,259	411,743	SH		SOLE		411,743	0	0
Medpace Holdings, Inc.	Common	58506Q109	2,109	18,871	SH		SOLE		18,871	0	0
Medtronic plc	Shares	G5960L103	55,588	534,914	SH		SOLE		534,914	0	0
Merck & Co., Inc.	Common	58933Y105	87,654	1,056,706	SH		SOLE		1,056,706	0	0
Mettler-Toledo International Inc.	Common	592688105	9,464	9,800	SH		SOLE		9,800	0	0
Milestone Pharmaceuticals Inc.	Common	59935V107	1,561	213,310	SH		SOLE		213,310	0	0
Mirati Therapeutics, Inc.	Common	60468T105	13,082	78,784	SH		SOLE		78,784	0	0
Moderna, Inc.	Common	60770K107	32,570	460,359	SH		SOLE		460,359	0	0
Molecular Templates, Inc.	Common	608550109	2,400	219,822	SH		SOLE		219,822	0	0
Molina Healthcare, Inc.	Common	60855R100	7,810	42,669	SH		SOLE		42,669	0	0
MorphoSys AG	Sponsored ADS	617760202	2,570	81,867	SH		SOLE		81,867	0	0
Mylan N.V.	Shares	N59465109	14,989	1,010,754	SH		SOLE		1,010,754	0	0
MyoKardia, Inc.	Common	62857M105	2,631	19,300	SH		SOLE		19,300	0	0
National Health Investors, Inc.	Common	63633D104	605	10,038	SH		SOLE		10,038	0	0
Nektar Therapeutics	Common	640268108	4,364	263,079	SH		SOLE		263,079	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	6,078	63,203	SH		SOLE		63,203	0	0
New Senior Investment Group Inc.	Common	648691103	1,026	256,398	SH		SOLE		256,398	0	0
Novartis AG	Sponsored ADR	66987V109	13,177	151,525	SH		SOLE		151,525	0	0
Novavax, Inc.	Common	670002401	1,249	11,523	SH		SOLE		11,523	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	9,304	134,005	SH		SOLE		134,005	0	0
NovoCure Ltd.	Ordinary Shares	G6674U108	13,006	116,845	SH		SOLE		116,845	0	0
NuCana plc	Sponsored ADR	67022C106	2,382	460,672	SH		SOLE		460,672	0	0
Omega Healthcare Investors, Inc.	Common	681936100	9,175	306,433	SH		SOLE		306,433	0	0
Ovid Therapeutics Inc.	Sponsored ADR	690469101	2,139	372,733	SH		SOLE		372,733	0	0
PerkinElmer, Inc.	Common	714046109	4,831	38,494	SH		SOLE		38,494	0	0
Perrigo Co. plc	Shares	G97822103	2,352	51,224	SH		SOLE		51,224	0	0
Pfizer Inc.	Common	717081103	62,235	1,695,768	SH		SOLE		1,695,768	0	0
Physicians Realty Trust	Common	71943U104	8,879	495,733	SH		SOLE		495,733	0	0
Pieris Pharmaceuticals, Inc.	Common	720795103	3,000	1,449,269	SH		SOLE		1,449,269	0	0
PRA Health Sciences, Inc.	Common	69354M108	8,067	79,526	SH		SOLE		79,526	0	0
Quest Diagnostics Inc.	Common	74834L100	12,555	109,659	SH		SOLE		109,659	0	0
Reata Pharmaceuticals, Inc.	Class A	75615P103	7,447	76,440	SH		SOLE		76,440	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	116,092	207,388	SH		SOLE		207,388	0	0
REGENXBIO Inc.	Common	75901B107	597	21,700	SH		SOLE		21,700	0	0
ResMed Inc.	Common	761152107	16,641	97,069	SH		SOLE		97,069	0	0
Revance Therapeutics, Inc.	Common	761330109	2,158	85,840	SH		SOLE		85,840	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	7,039	510,660	SH		SOLE		510,660	0	0
Sage Therapeutics, Inc.	Common	78667J108	5,880	96,211	SH		SOLE		96,211	0	0
Sanofi	Sponsored ADR	80105N105	19,161	381,920	SH		SOLE		381,920	0	0
Sarepta Therapeutics, Inc.	Common	803607100	28,997	206,487	SH		SOLE		206,487	0	0
Seagen Inc.	Common	812578102	65,987	337,204	SH		SOLE		337,204	0	0
Smith & Nephew plc	Shares	83175M205	3,893	99,560	SH		SOLE		99,560	0	0
Spectrum Pharmaceuticals, Inc.	Common	84763A108	468	114,670	SH		SOLE		114,670	0	0
STERIS plc	Shares	G8473T100	22,337	126,779	SH		SOLE		126,779	0	0
Stryker Corp.	Common	863667101	32,887	157,830	SH		SOLE		157,830	0	0
Sutro Biopharma, Inc.	Common	869367102	6,445	641,268	SH		SOLE		641,268	0	0
Syneos Health, Inc.	Class A	87166B102	5,741	108,001	SH		SOLE		108,001	0	0
Takeda Pharmaceutic	Sponsored ADS	874060205	3,749	210,146	SH		SOLE		210,146	0	0
Teleflex Inc.	Common	879369106	5,873	17,252	SH		SOLE		17,252	0	0
Tenet Healthcare Corp.	Common	88033G407	2,371	96,736	SH		SOLE		96,736	0	0
Tetraphase Pharmaceuticals, Inc.	Common	881CVR013	9	42,965	SH		SOLE		42,965	0	0
Teva Pharmaceutical Industries Ltd.	Sponsored ADR	881624209	7,081	785,851	SH		SOLE		785,851	0	0
Theravance Biopharma, Inc.	Common	G8807B106	4,413	298,470	SH		SOLE		298,470	0	0
Thermo Fisher Scientific Inc.	Common	883556102	13,008	29,461	SH		SOLE		29,461	0	0
Tricida, Inc.	Common	89610F101	456	50,370	SH		SOLE		50,370	0	0
Trillium Therapeutics Inc.	Common	89620X506	6,367	448,049	SH		SOLE		448,049	0	0
Turning Point Therapeutics, Inc.	Common	90041T108	496	5,677	SH		SOLE		5,677	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	8,012	97,480	SH		SOLE		97,480	0	0
uniQure N.V.	Shares	N90064101	2,322	63,039	SH		SOLE		63,039	0	0
United Therapeutics Corp.	Class B	91307C102	6,415	63,513	SH		SOLE		63,513	0	0
Unitedhealth Group Inc.	Common	91324P102	57,907	185,735	SH		SOLE		185,735	0	0
Universal Health Realty Income Trust	Shares	91359E105	642	11,258	SH		SOLE		11,258	0	0
Ventas, Inc.	Common	92276F100	8,732	208,108	SH		SOLE		208,108	0	0
Verona Pharma plc	Sponsored ADR	925050106	2,967	475,402	SH		SOLE		475,402	0	0
Vertex Pharmaceuticals Inc.	Common	92532F100	109,218	401,360	SH		SOLE		401,360	0	0
VYNE Therapeutics Inc.	Common	92941V100	899	541,584	SH		SOLE		541,584	0	0
Waters Corp.	Common	941848103	21,429	109,510	SH		SOLE		109,510	0	0
Welltower Inc.	Common	95040Q104	11,188	203,083	SH		SOLE		203,083	0	0
Xencor, Inc.	Common	98401F105	5,750	148,231	SH		SOLE		148,231	0	0
Y-mAbs Therapeutics, Inc.	Common	984241109	2,939	76,548	SH		SOLE		76,548	0	0
Zai Lab Ltd.	ADR	98887Q104	3,121	37,523	SH		SOLE		37,523	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	26,130	191,937	SH		SOLE		191,937	0	0
Zoetis Inc.	Class A	98978V103	9,347	56,521	SH		SOLE		56,521	0	0
Zogenix, Inc.	Common	98978L204	5,978	333,402	SH		SOLE		333,402	0	0
Zymeworks Inc.	Common	98985W102	2,606	55,938	SH		SOLE		55,938	0	0