Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
1Life Healthcare, Inc.	Common	68269G107	1,222	31,266	SH		SOLE		31,266	0	0
Abbott Laboratories	Common	002824100	89,120	743,657	SH		SOLE		743,657	0	0
AbbVie Inc.	Common	00287Y109	67,070	619,759	SH		SOLE		619,759	0	0
ACADIA Pharmaceuticals Inc.	Common	004225108	8,560	331,789	SH		SOLE		331,789	0	0
Adaptive Biotechnologies Corp.	Common	00650F109	13,597	337,722	SH		SOLE		337,722	0	0
Addus HomeCare Corp.	Common	006739106	3,937	37,640	SH		SOLE		37,640	0	0
Affimed N.V.	Common	N01045108	2,278	288,019	SH		SOLE		288,019	0	0
Agilent Technologies, Inc.	Common	00846U101	6,678	52,525	SH		SOLE		52,525	0	0
Alexion Pharmaceuticals, Inc.	Common	015351109	16,926	110,693	SH		SOLE		110,693	0	0
Align Technology, Inc.	Common	016255101	5,375	9,925	SH		SOLE		9,925	0	0
Alkermes plc	Shares	G01767105	3,174	169,930	SH		SOLE		169,930	0	0
Allakos Inc.	Common	01671P100	18,783	163,645	SH		SOLE		163,645	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	21,871	154,902	SH		SOLE		154,902	0	0
Amedisys, Inc.	Common	023436108	5,136	19,395	SH		SOLE		19,395	0	0
Amgen Inc.	Common	031162100	103,644	416,560	SH		SOLE		416,560	0	0
Amicus Therapeutics, Inc.	Common	03152W109	6,142	621,659	SH		SOLE		621,659	0	0
Anthem, Inc.	Common	036752103	59,147	164,777	SH		SOLE		164,777	0	0
Apellis Pharmaceuticals, Inc.	Common	03753U106	6,545	152,538	SH		SOLE		152,538	0	0
ARCA biopharma, Inc.	Common	00211Y506	118	32,461	SH		SOLE		32,461	0	0
Arcutis Biotherapeutics, Inc.	Common	03969K108	3,808	131,633	SH		SOLE		131,633	0	0
Ardelyx, Inc.	Common	039697107	4,023	607,698	SH		SOLE		607,698	0	0
Arena Pharmaceuticals, Inc.	Common	040047607	13,627	196,385	SH		SOLE		196,385	0	0
Argenx SE	Sponsored ADR	04016X101	17,720	64,344	SH		SOLE		64,344	0	0
Arrowhead Pharmaceuticals, Inc.	Common	04280A100	8,812	132,886	SH		SOLE		132,886	0	0
Arvinas, Inc.	Common	04335A105	5,684	85,997	SH		SOLE		85,997	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	15,251	118,336	SH		SOLE		118,336	0	0
Assertio Holdings, Inc.	Common	04546C106	1,121	1,642,302	SH		SOLE		1,642,302	0	0
AstraZeneca PLC	Sponsored ADR	046353108	17,120	344,333	SH		SOLE		344,333	0	0
Atreca, Inc.	Class A Common	04965G109	5,403	352,424	SH		SOLE		352,424	0	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	5,167	397,920	SH		SOLE		397,920	0	0
Becton, Dickinson and Co.	Common	075887109	10,530	43,307	SH		SOLE		43,307	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	14,059	40,389	SH		SOLE		40,389	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481404	23	6,000	SH		SOLE		6,000	0	0
Bio-Techne Corp.	Common	09073M104	2,903	7,600	SH		SOLE		7,600	0	0
Biogen Inc.	Common	09062X103	69,055	246,844	SH		SOLE		246,844	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	9,666	128,004	SH		SOLE		128,004	0	0
BioNTech SE	Sponsored ADS	09075V102	7,514	68,814	SH		SOLE		68,814	0	0
Black Diamond Therapeutics, Inc.	Common	09203E105	3,202	131,990	SH		SOLE		131,990	0	0
Blueprint Medicines Corp.	Common	09627Y109	11,930	122,699	SH		SOLE		122,699	0	0
Boston Scientific Corp.	Common	101137107	7,186	185,931	SH		SOLE		185,931	0	0
BridgeBio Pharma, Inc.	Common	10806X102	4,602	74,714	SH		SOLE		74,714	0	0
Bristol-Myers Squibb Co.	Common	110122108	56,341	892,453	SH		SOLE		892,453	0	0
Catalent, Inc.	Common	148806102	8,427	80,025	SH		SOLE		80,025	0	0
Celldex Therapeutics, Inc.	Common	15117B202	145	7,053	SH		SOLE		7,053	0	0
Cellectis	Sponsored ADR	15117K103	242	11,955	SH		SOLE		11,955	0	0
Centene Corp.	Common	15135B101	4,301	67,290	SH		SOLE		67,290	0	0
Charles River Laboratories International, Inc.	Common	159864107	12,484	43,074	SH		SOLE		43,074	0	0
ChemoCentryx, Inc.	Common	16383L106	7,401	144,447	SH		SOLE		144,447	0	0
Cigna Corp.	Common	125523100	45,912	189,921	SH		SOLE		189,921	0	0
Clearside Biomedical, Inc.	Common	185063104	408	165,330	SH		SOLE		165,330	0	0
Cogent Biosciences, Inc.	Common	19240Q201	4,721	537,742	SH		SOLE		537,742	0	0
Community Health Systems, Inc.	Common	203668108	1,589	117,535	SH		SOLE		117,535	0	0
Community Healthcare Trust Inc.	Common	20369C106	687	14,900	SH		SOLE		14,900	0	0
Corbus Pharmaceuticals Holdings, Inc.	Common	21833P103	815	413,481	SH		SOLE		413,481	0	0
CRISPR Therapeutics AG	Namen AKT	H17182108	18,394	150,958	SH		SOLE		150,958	0	0
CVS Health Corp.	Common	126650100	16,550	219,995	SH		SOLE		219,995	0	0
CymaBay Therapeutics, Inc.	Common	23257D103	400	88,102	SH		SOLE		88,102	0	0
Danaher Corp.	Common	235851102	43,044	191,240	SH		SOLE		191,240	0	0
Deciphera Pharmaceuticals, Inc.	Common	24344T101	13,797	307,703	SH		SOLE		307,703	0	0
Denali Therapeutics Inc.	Common	24823R105	8,570	150,086	SH		SOLE		150,086	0	0
DENTSPLY SIRONA Inc.	Common	24906P109	22,425	351,427	SH		SOLE		351,427	0	0
Dexcom, Inc.	Common	252131107	26,826	74,643	SH		SOLE		74,643	0	0
Dicerna Pharmaceuticals, Inc.	Common	253031108	1,743	68,150	SH		SOLE		68,150	0	0
Diversified Healthcare Trust	Common	25525P107	1,710	357,720	SH		SOLE		357,720	0	0
Editas Medicine, Inc.	Common	28106W103	638	15,190	SH		SOLE		15,190	0	0
Edwards Lifesciences Corp.	Common	28176E108	19,969	238,755	SH		SOLE		238,755	0	0
Eli Lilly and Co.	Common	532457108	54,573	292,114	SH		SOLE		292,114	0	0
Endo International plc	Shares	G30401106	3,939	531,570	SH		SOLE		531,570	0	0
Exact Sciences Corp.	Common	30063P105	22,047	167,302	SH		SOLE		167,302	0	0
Exelixis, Inc.	Common	30161Q104	24,870	1,100,920	SH		SOLE		1,100,920	0	0
Fate Therapeutics, Inc.	Common	31189P102	12,396	150,343	SH		SOLE		150,343	0	0
Five Star Senior Living Inc.	Common	33832D205	148	24,237	SH		SOLE		24,237	0	0
Forma Therapeutics Holdings, Inc.	Shares	34633R104	4,198	149,825	SH		SOLE		149,825	0	0
G1 Therapeutics, Inc.	Common	3621LQ109	9,426	391,754	SH		SOLE		391,754	0	0
Galera Therapeutics, Inc.	Common	36338D108	9,189	1,041,845	SH		SOLE		1,041,845	0	0
Gamida Cell Ltd.	Shares	M47364100	956	118,142	SH		SOLE		118,142	0	0
Genmab A/S	Sponsored ADS	372303206	2,397	73,015	SH		SOLE		73,015	0	0
Gilead Sciences, Inc.	Common	375558103	117,362	1,815,906	SH		SOLE		1,815,906	0	0
Global Medical REIT Inc.	Common	37954A204	2,293	174,897	SH		SOLE		174,897	0	0
Grifols, S.A.	Sponsored ADR	398438408	819	47,373	SH		SOLE		47,373	0	0
Guardant Health, Inc.	Common	40131M109	24,230	158,727	SH		SOLE		158,727	0	0
HCA Healthcare, Inc.	Common	40412C101	28,797	152,897	SH		SOLE		152,897	0	0
Health Care Select Sector SPDR Fund	SBI Healthcare	81369Y209	1,174	10,055	SH		SOLE		10,055	0	0
Healthcare Realty Trust Inc.	Common	421946104	3,154	104,024	SH		SOLE		104,024	0	0
Healthcare Trust of America, Inc.	Common	42225P501	1,949	70,662	SH		SOLE		70,662	0	0
Healthpeak Properties, Inc.	Common	42250P103	4,773	150,392	SH		SOLE		150,392	0	0
Helix Acquisition Corp.	Class A Common	G4444C102	2,559	250,000	SH		SOLE		250,000	0	0
Heron Therapeutics, Inc.	Common	427746102	2,126	131,183	SH		SOLE		131,183	0	0
Hologic, Inc.	Common	436440101	2,422	32,564	SH		SOLE		32,564	0	0
Horizon Therapeutics plc	Shares	G46188101	74,638	810,932	SH		SOLE		810,932	0	0
Humana Inc.	Common	444859102	15,655	37,341	SH		SOLE		37,341	0	0
I-Mab	Sponsored ADS	44975P103	8,089	166,896	SH		SOLE		166,896	0	0
Icon plc	Shares	G4705A100	4,633	23,592	SH		SOLE		23,592	0	0
IDEXX Laboratories, Inc.	Common	45168D104	17,035	34,814	SH		SOLE		34,814	0	0
Illumina, Inc.	Common	452327109	94,783	246,793	SH		SOLE		246,793	0	0
Incyte Corp.	Common	45337C102	8,752	107,687	SH		SOLE		107,687	0	0
Insmed Inc.	Common	457669307	3,351	98,387	SH		SOLE		98,387	0	0
Intellia Therapeutics, Inc.	Common	45826J105	4,268	53,180	SH		SOLE		53,180	0	0
Intercept Pharmaceuticals, Inc.	Common	45845P108	1,779	77,067	SH		SOLE		77,067	0	0
Intra-Cellular Therapies, Inc.	Common	46116X101	7,888	232,476	SH		SOLE		232,476	0	0
Intuitive Surgical, Inc.	Common	46120E602	15,736	21,296	SH		SOLE		21,296	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	9,728	216,371	SH		SOLE		216,371	0	0
Iovance Biotherapeutics, Inc.	Common	462260100	16,482	520,595	SH		SOLE		520,595	0	0
IQVIA Holdings Inc.	Common	46266C105	13,494	69,866	SH		SOLE		69,866	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	11,088	67,456	SH		SOLE		67,456	0	0
Johnson & Johnson	Common	478160104	99,409	604,864	SH		SOLE		604,864	0	0
Jounce Therapeutics, Inc.	Common	481116101	3,926	382,237	SH		SOLE		382,237	0	0
KalVista Pharmaceuticals, Inc.	Common	483497103	1,285	50,000	SH		SOLE		50,000	0	0
Karuna Therapeutics, Inc.	Common	48576A100	10,248	85,236	SH		SOLE		85,236	0	0
Koninklijke Philips N.V.	NY Reg Sh	500472303	3,247	56,927	SH		SOLE		56,927	0	0
Kura Oncology, Inc.	Common	50127T109	7,731	273,463	SH		SOLE		273,463	0	0
Laboratory Corp. of America Holdings	Sponsored ADR	50540R409	25,396	99,580	SH		SOLE		99,580	0	0
LTC Properties, Inc.	Common	502175102	7,605	182,293	SH		SOLE		182,293	0	0
Madrigal Pharmaceuticals, Inc.	Common	558868105	1,560	13,340	SH		SOLE		13,340	0	0
McKesson Corp.	Common	58155Q103	24,565	125,948	SH		SOLE		125,948	0	0
Medical Properties Trust, Inc.	Common	58463J304	8,762	411,743	SH		SOLE		411,743	0	0
Medpace Holdings, Inc.	Common	58506Q109	3,096	18,871	SH		SOLE		18,871	0	0
Medtronic plc	Shares	G5960L103	58,145	492,214	SH		SOLE		492,214	0	0
Merck & Co., Inc.	Common	58933Y105	41,760	541,703	SH		SOLE		541,703	0	0
Mereo BioPharma Group plc	ADS	589492107	3,361	997,290	SH		SOLE		997,290	0	0
Mettler-Toledo International Inc.	Common	592688105	11,326	9,800	SH		SOLE		9,800	0	0
Mirati Therapeutics, Inc.	Common	60468T105	14,352	83,784	SH		SOLE		83,784	0	0
Moderna, Inc.	Common	60770K107	61,848	472,302	SH		SOLE		472,302	0	0
Molecular Templates, Inc.	Common	608550109	2,517	199,420	SH		SOLE		199,420	0	0
Molina Healthcare, Inc.	Common	60855R100	9,296	39,769	SH		SOLE		39,769	0	0
Morphic Holding, Inc.	Common	61775R105	5,667	89,559	SH		SOLE		89,559	0	0
MorphoSys AG	Sponsored ADS	617760202	1,785	81,867	SH		SOLE		81,867	0	0
National Health Investors, Inc.	Common	63633D104	726	10,038	SH		SOLE		10,038	0	0
Nektar Therapeutics	Common	640268108	3,609	180,438	SH		SOLE		180,438	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	20,704	212,891	SH		SOLE		212,891	0	0
New Senior Investment Group Inc.	Common	648691103	1,597	256,398	SH		SOLE		256,398	0	0
Nkarta, Inc.	Common	65487U108	954	28,988	SH		SOLE		28,988	0	0
Novartis AG	Sponsored ADR	66987V109	11,645	136,225	SH		SOLE		136,225	0	0
Novavax, Inc.	Common	670002401	19,069	105,176	SH		SOLE		105,176	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	3,264	48,406	SH		SOLE		48,406	0	0
Omega Healthcare Investors, Inc.	Common	681936100	11,225	306,433	SH		SOLE		306,433	0	0
Ovid Therapeutics Inc.	Sponsored ADR	690469101	1,498	372,733	SH		SOLE		372,733	0	0
Owens & Minor, Inc.	Common	690732102	10,000	266,023	SH		SOLE		266,023	0	0
PerkinElmer, Inc.	Common	714046109	4,759	37,094	SH		SOLE		37,094	0	0
Perrigo Co. plc	Shares	G97822103	2,073	51,224	SH		SOLE		51,224	0	0
Personalis, Inc.	Common	71535D106	4,423	179,731	SH		SOLE		179,731	0	0
Pfizer Inc.	Common	717081103	25,552	705,259	SH		SOLE		705,259	0	0
Physicians Realty Trust	Common	71943U104	8,760	495,733	SH		SOLE		495,733	0	0
Pieris Pharmaceuticals, Inc.	Common	720795103	2,630	1,023,348	SH		SOLE		1,023,348	0	0
PRA Health Sciences, Inc.	Common	69354M108	15,938	103,943	SH		SOLE		103,943	0	0
Praxis Precision Medicines, Inc.	Common	74006W108	2,457	75,000	SH		SOLE		75,000	0	0
Precision BioSciences, Inc.	Common	74019P108	652	63,001	SH		SOLE		63,001	0	0
R1 RCM Inc.	Common	749397105	3,047	123,461	SH		SOLE		123,461	0	0
Reata Pharmaceuticals, Inc.	Class A	75615P103	3,810	38,219	SH		SOLE		38,219	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	72,629	153,505	SH		SOLE		153,505	0	0
REGENXBIO Inc.	Common	75901B107	740	21,700	SH		SOLE		21,700	0	0
Replimune Group, Inc.	Common	76029N106	6,684	219,060	SH		SOLE		219,060	0	0
ResMed Inc.	Common	761152107	25,677	132,344	SH		SOLE		132,344	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	8,865	510,660	SH		SOLE		510,660	0	0
Sage Therapeutics, Inc.	Common	78667J108	8,542	114,119	SH		SOLE		114,119	0	0
Sanofi	Sponsored ADR	80105N105	4,034	81,554	SH		SOLE		81,554	0	0
Sarepta Therapeutics, Inc.	Common	803607100	9,613	128,987	SH		SOLE		128,987	0	0
Scholar Rock Holding Corp.	Common	80706P103	2,425	47,869	SH		SOLE		47,869	0	0
Seagen Inc.	Common	81181C104	31,312	225,490	SH		SOLE		225,490	0	0
Smith & Nephew plc	Shares	83175M205	3,773	99,560	SH		SOLE		99,560	0	0
Spectrum Pharmaceuticals, Inc.	Common	84763A108	374	114,670	SH		SOLE		114,670	0	0
STERIS plc	Shares	G8473T100	24,149	126,779	SH		SOLE		126,779	0	0
Stryker Corp.	Common	863667101	36,983	151,830	SH		SOLE		151,830	0	0
Sutro Biopharma, Inc.	Common	869367102	13,060	573,823	SH		SOLE		573,823	0	0
Syneos Health, Inc.	Class A	87166B102	20,680	272,647	SH		SOLE		272,647	0	0
Takeda Pharmaceutical Co. Ltd.	Sponsored ADS	874060205	3,837	210,146	SH		SOLE		210,146	0	0
TCR2 Therapeutics Inc.	Common	87808K106	5,207	235,808	SH		SOLE		235,808	0	0
Teladoc Health, Inc.	Common	87918A105	5,391	29,664	SH		SOLE		29,664	0	0
Teleflex Inc.	Common	879369106	914	2,200	SH		SOLE		2,200	0	0
Tenet Healthcare Corp.	Common	88033G407	3,137	60,336	SH		SOLE		60,336	0	0
Tetraphase Pharmaceuticals, Inc.	Common	881CVR013	9	42,965	SH		SOLE		42,965	0	0
Teva Pharmaceutical Industries Ltd.	Sponsored ADR	881624209	7,623	660,551	SH		SOLE		660,551	0	0
Theravance Biopharma, Inc.	Common	G8807B106	9,313	456,296	SH		SOLE		456,296	0	0
Thermo Fisher Scientific Inc.	Common	883556102	51,869	113,653	SH		SOLE		113,653	0	0
Travere Therapeutics, Inc.	Common	89422G107	5,315	212,869	SH		SOLE		212,869	0	0
Trillium Therapeutics Inc.	Common	89620X506	5,684	529,226	SH		SOLE		529,226	0	0
Turning Point Therapeutics, Inc.	Common	90041T108	11,287	119,324	SH		SOLE		119,324	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	11,099	97,480	SH		SOLE		97,480	0	0
uniQure N.V.	Shares	N90064101	4,211	125,003	SH		SOLE		125,003	0	0
United Therapeutics Corp.	Class B	91307C102	10,624	63,513	SH		SOLE		63,513	0	0
Unitedhealth Group Inc.	Common	91324P102	78,985	212,285	SH		SOLE		212,285	0	0
Universal Health Realty Income Trust	Shares	91359E105	763	11,258	SH		SOLE		11,258	0	0
Universal Health Services, Inc.	Class B	913903100	9,514	71,323	SH		SOLE		71,323	0	0
Ventas, Inc.	Common	92276F100	11,100	208,108	SH		SOLE		208,108	0	0
Verona Pharma plc	Sponsored ADR	925050106	6,286	751,905	SH		SOLE		751,905	0	0
Vertex Pharmaceuticals Inc.	Common	92532F100	84,943	395,288	SH		SOLE		395,288	0	0
Vir Biotechnology, Inc.	Common	92764N102	4,173	81,400	SH		SOLE		81,400	0	0
VYNE Therapeutics Inc.	Common	92941V209	927	135,395	SH		SOLE		135,395	0	0
Waters Corp.	Common	941848103	29,187	102,710	SH		SOLE		102,710	0	0
Welltower Inc.	Common	95040Q104	14,547	203,083	SH		SOLE		203,083	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	2,970	165,898	SH		SOLE		165,898	0	0
Y-mAbs Therapeutics, Inc.	Common	984241109	5,982	197,820	SH		SOLE		197,820	0	0
Zai Lab Ltd.	ADR	98887Q104	5,007	37,523	SH		SOLE		37,523	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	33,267	207,814	SH		SOLE		207,814	0	0
Zoetis Inc.	Class A	98978V103	8,901	56,521	SH		SOLE		56,521	0	0
Zogenix, Inc.	Common	98978L204	1,737	88,977	SH		SOLE		88,977	0	0