Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
1Life Healthcare, Inc.	Common	68269G107	1,034	31,266	SH		SOLE		31,266	0	0
Abbott Laboratories	Common	002824100	87,063	750,997	SH		SOLE		750,997	0	0
AbbVie Inc.	Common	00287Y109	69,533	617,303	SH		SOLE		617,303	0	0
ACADIA Pharmaceuticals Inc.	Common	004225108	8,092	331,789	SH		SOLE		331,789	0	0
Adaptive Biotechnologies Corp.	Common	00650F109	13,799	337,722	SH		SOLE		337,722	0	0
Addus HomeCare Corp.	Common	006739106	4,732	54,237	SH		SOLE		54,237	0	0
Affimed N.V.	Common	N01045108	7,724	908,736	SH		SOLE		908,736	0	0
Agilent Technologies, Inc.	Common	00846U101	7,764	52,525	SH		SOLE		52,525	0	0
Alexion Pharmaceuticals, Inc.	Common	015351109	11,841	64,453	SH		SOLE		64,453	0	0
Align Technology, Inc.	Common	016255101	6,064	9,925	SH		SOLE		9,925	0	0
Allakos Inc.	Common	01671P100	11,358	133,045	SH		SOLE		133,045	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	22,800	134,495	SH		SOLE		134,495	0	0
Amedisys, Inc.	Common	023436108	11,774	48,070	SH		SOLE		48,070	0	0
Amgen Inc.	Common	031162100	112,955	463,405	SH		SOLE		463,405	0	0
Amicus Therapeutics, Inc.	Common	03152W109	5,993	621,659	SH		SOLE		621,659	0	0
Anthem, Inc.	Common	036752103	41,133	107,734	SH		SOLE		107,734	0	0
Apellis Pharmaceuticals, Inc.	Common	03753U106	9,640	152,538	SH		SOLE		152,538	0	0
ARCA biopharma, Inc.	Common	00211Y506	113	32,461	SH		SOLE		32,461	0	0
Arcutis Biotherapeutics, Inc.	Common	03969K108	3,592	131,633	SH		SOLE		131,633	0	0
Ardelyx, Inc.	Common	039697107	4,089	539,408	SH		SOLE		539,408	0	0
Arena Pharmaceuticals, Inc.	Common	040047607	13,393	196,385	SH		SOLE		196,385	0	0
argenx SE	Sponsored ADR	04016X101	22,403	74,410	SH		SOLE		74,410	0	0
Arrowhead Pharmaceuticals, Inc.	Common	04280A100	11,006	132,886	SH		SOLE		132,886	0	0
Arvinas, Inc.	Common	04335A105	6,622	85,997	SH		SOLE		85,997	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	20,211	153,636	SH		SOLE		153,636	0	0
Assertio Holdings, Inc.	Common	04546C205	640	410,575	SH		SOLE		410,575	0	0
AstraZeneca PLC	Sponsored ADR	046353108	26,853	448,298	SH		SOLE		448,298	0	0
Atreca, Inc.	Class A Common	04965G109	3,003	352,424	SH		SOLE		352,424	0	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	5,157	397,920	SH		SOLE		397,920	0	0
Becton, Dickinson and Co.	Common	075887109	10,532	43,307	SH		SOLE		43,307	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	15,781	45,983	SH		SOLE		45,983	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481404	20	6,000	SH		SOLE		6,000	0	0
Bio-Techne Corp.	Common	09073M104	3,422	7,600	SH		SOLE		7,600	0	0
Biogen Inc.	Common	09062X103	72,413	209,124	SH		SOLE		209,124	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	10,681	128,004	SH		SOLE		128,004	0	0
BioNTech SE	Sponsored ADS	09075V102	12,778	57,073	SH		SOLE		57,073	0	0
Black Diamond Therapeutics, Inc.	Common	09203E105	1,609	131,990	SH		SOLE		131,990	0	0
Blueprint Medicines Corp.	Common	09627Y109	10,793	122,699	SH		SOLE		122,699	0	0
Boston Scientific Corp.	Common	101137107	7,950	185,931	SH		SOLE		185,931	0	0
BridgeBio Pharma, Inc.	Common	10806X102	11,507	188,767	SH		SOLE		188,767	0	0
Bristol-Myers Squibb Co.	Common	110122108	43,832	655,973	SH		SOLE		655,973	0	0
Catalent, Inc.	Common	148806102	8,652	80,025	SH		SOLE		80,025	0	0
Celldex Therapeutics, Inc.	Common	15117B202	236	7,053	SH		SOLE		7,053	0	0
Centene Corp.	Common	15135B101	4,907	67,290	SH		SOLE		67,290	0	0
Charles River Laboratories International, Inc.	Common	159864107	20,225	54,674	SH		SOLE		54,674	0	0
ChemoCentryx, Inc.	Common	16383L106	1,047	78,197	SH		SOLE		78,197	0	0
Cigna Corp.	Common	125523100	50,026	211,018	SH		SOLE		211,018	0	0
Cogent Biosciences, Inc.	Common	19240Q201	4,361	537,742	SH		SOLE		537,742	0	0
Community Health Systems, Inc.	Common	203668108	1,568	101,535	SH		SOLE		101,535	0	0
Community Healthcare Trust Inc.	Common	20369C106	707	14,900	SH		SOLE		14,900	0	0
Corbus Pharmaceuticals Holdings, Inc.	Common	21833P103	757	413,481	SH		SOLE		413,481	0	0
CRISPR Therapeutics AG	Namen AKT	H17182108	26,281	162,337	SH		SOLE		162,337	0	0
CVS Health Corp.	Common	126650100	12,303	147,453	SH		SOLE		147,453	0	0
CymaBay Therapeutics, Inc.	Common	23257D103	384	88,102	SH		SOLE		88,102	0	0
Danaher Corp.	Common	235851102	44,612	166,240	SH		SOLE		166,240	0	0
Deciphera Pharmaceuticals, Inc.	Common	24344T101	11,265	307,703	SH		SOLE		307,703	0	0
Denali Therapeutics Inc.	Common	24823R105	11,773	150,086	SH		SOLE		150,086	0	0
DENTSPLY SIRONA Inc.	Common	24906P109	24,187	382,344	SH		SOLE		382,344	0	0
Dexcom, Inc.	Common	252131107	35,336	82,755	SH		SOLE		82,755	0	0
Dicerna Pharmaceuticals, Inc.	Common	253031108	2,543	68,150	SH		SOLE		68,150	0	0
Diversified Healthcare Trust	Common	25525P107	1,495	357,720	SH		SOLE		357,720	0	0
Editas Medicine, Inc.	Common	28106W103	860	15,190	SH		SOLE		15,190	0	0
Edwards Lifesciences Corp.	Common	28176E108	22,946	221,555	SH		SOLE		221,555	0	0
Eli Lilly and Co.	Common	532457108	58,886	256,561	SH		SOLE		256,561	0	0
Endo International plc	Shares	G30401106	2,488	531,570	SH		SOLE		531,570	0	0
Exact Sciences Corp.	Common	30063P105	24,819	199,654	SH		SOLE		199,654	0	0
Exelixis, Inc.	Common	30161Q104	9,104	499,657	SH		SOLE		499,657	0	0
Fate Therapeutics, Inc.	Common	31189P102	6,312	72,727	SH		SOLE		72,727	0	0
Five Star Senior Living Inc.	Common	33832D205	140	24,237	SH		SOLE		24,237	0	0
Forma Therapeutics Holdings, Inc.	Shares	34633R104	3,729	149,825	SH		SOLE		149,825	0	0
G1 Therapeutics, Inc.	Common	3621LQ109	13,699	624,369	SH		SOLE		624,369	0	0
Galera Therapeutics, Inc.	Common	36338D108	10,241	1,041,845	SH		SOLE		1,041,845	0	0
Gamida Cell Ltd.	Shares	M47364100	757	118,142	SH		SOLE		118,142	0	0
Gilead Sciences, Inc.	Common	375558103	112,571	1,634,785	SH		SOLE		1,634,785	0	0
Global Medical REIT Inc.	Common	37954A204	2,581	174,897	SH		SOLE		174,897	0	0
Grifols, S.A.	Sponsored ADR	398438408	822	47,373	SH		SOLE		47,373	0	0
Guardant Health, Inc.	Common	40131M109	19,712	158,727	SH		SOLE		158,727	0	0
HCA Healthcare, Inc.	Common	40412C101	25,789	124,743	SH		SOLE		124,743	0	0
Health Care Select Sector SPDR Fund	SBI Healthcare	81369Y209	23,796	188,930	SH		SOLE		188,930	0	0
Healthcare Realty Trust Inc.	Common	421946104	3,142	104,024	SH		SOLE		104,024	0	0
Healthcare Trust of America, Inc.	Common	42225P501	1,887	70,662	SH		SOLE		70,662	0	0
Healthpeak Properties, Inc.	Common	42250P103	5,007	150,392	SH		SOLE		150,392	0	0
Helix Acquisition Corp.	Class A Common	G4444C102	2,583	250,000	SH		SOLE		250,000	0	0
Hologic, Inc.	Common	436440101	2,173	32,564	SH		SOLE		32,564	0	0
Horizon Therapeutics plc	Shares	G46188101	87,679	936,340	SH		SOLE		936,340	0	0
Humana Inc.	Common	444859102	25,738	58,135	SH		SOLE		58,135	0	0
I-Mab	Sponsored ADS	44975P103	13,649	162,580	SH		SOLE		162,580	0	0
Icon plc	Shares	G4705A100	7,515	36,357	SH		SOLE		36,357	0	0
IDEXX Laboratories, Inc.	Common	45168D104	21,987	34,814	SH		SOLE		34,814	0	0
Illumina, Inc.	Common	452327109	95,498	201,809	SH		SOLE		201,809	0	0
Incyte Corp.	Common	45337C102	9,060	107,687	SH		SOLE		107,687	0	0
Insmed Inc.	Common	457669307	2,800	98,387	SH		SOLE		98,387	0	0
Intellia Therapeutics, Inc.	Common	45826J105	9,420	58,180	SH		SOLE		58,180	0	0
Intercept Pharmaceuticals, Inc.	Common	45845P108	1,539	77,067	SH		SOLE		77,067	0	0
Intra-Cellular Therapies, Inc.	Common	46116X101	8,276	202,756	SH		SOLE		202,756	0	0
Intuitive Surgical, Inc.	Common	46120E602	19,585	21,296	SH		SOLE		21,296	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	12,865	322,521	SH		SOLE		322,521	0	0
Iovance Biotherapeutics, Inc.	Common	462260100	12,191	468,538	SH		SOLE		468,538	0	0
IQVIA Holdings Inc.	Common	46266C105	13,756	56,766	SH		SOLE		56,766	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	11,983	67,456	SH		SOLE		67,456	0	0
Johnson & Johnson	Common	478160104	85,113	516,652	SH		SOLE		516,652	0	0
Jounce Therapeutics, Inc.	Common	481116101	2,599	382,237	SH		SOLE		382,237	0	0
KalVista Pharmaceuticals, Inc.	Common	483497103	2,396	100,000	SH		SOLE		100,000	0	0
Karuna Therapeutics, Inc.	Common	48576A100	11,451	100,458	SH		SOLE		100,458	0	0
Koninklijke Philips N.V.	NY Reg Sh	500472303	2,829	56,927	SH		SOLE		56,927	0	0
Kura Oncology, Inc.	Common	50127T109	5,702	273,463	SH		SOLE		273,463	0	0
Laboratory Corp. of America Holdings	Sponsored ADR	50540R409	19,413	70,374	SH		SOLE		70,374	0	0
LTC Properties, Inc.	Common	502175102	6,998	182,293	SH		SOLE		182,293	0	0
Madrigal Pharmaceuticals, Inc.	Common	558868105	1,299	13,340	SH		SOLE		13,340	0	0
McKesson Corp.	Common	58155Q103	28,823	150,715	SH		SOLE		150,715	0	0
Medical Properties Trust, Inc.	Common	58463J304	8,276	411,743	SH		SOLE		411,743	0	0
Medpace Holdings, Inc.	Common	58506Q109	3,333	18,871	SH		SOLE		18,871	0	0
Medtronic Plc	Shares	G5960L103	67,865	546,722	SH		SOLE		546,722	0	0
Merck & Co., Inc.	Common	58933Y105	42,128	541,703	SH		SOLE		541,703	0	0
Mereo BioPharma Group plc	ADS	589492107	3,312	1,044,790	SH		SOLE		1,044,790	0	0
Mettler-Toledo International Inc.	Common	592688105	13,576	9,800	SH		SOLE		9,800	0	0
Mirati Therapeutics, Inc.	Common	60468T105	13,534	83,784	SH		SOLE		83,784	0	0
Moderna, Inc.	Common	60770K107	109,448	465,777	SH		SOLE		465,777	0	0
Molecular Templates, Inc.	Common	608550109	1,559	199,420	SH		SOLE		199,420	0	0
Molina Healthcare, Inc.	Common	60855R100	16,097	63,610	SH		SOLE		63,610	0	0
MorphoSys AG	Sponsored ADS	617760202	1,576	81,867	SH		SOLE		81,867	0	0
National Health Investors, Inc.	Common	63633D104	673	10,038	SH		SOLE		10,038	0	0
Nektar Therapeutics	Common	640268108	3,096	180,438	SH		SOLE		180,438	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	20,719	212,891	SH		SOLE		212,891	0	0
New Senior Investment Group Inc.	Common	648691103	2,251	256,398	SH		SOLE		256,398	0	0
Nkarta, Inc.	Common	65487U108	919	28,988	SH		SOLE		28,988	0	0
Novartis AG	Sponsored ADR	66987V109	12,429	136,225	SH		SOLE		136,225	0	0
Novavax, Inc.	Common	670002401	18,598	87,596	SH		SOLE		87,596	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	4,055	48,406	SH		SOLE		48,406	0	0
Omega Healthcare Investors, Inc.	Common	681936100	11,120	306,433	SH		SOLE		306,433	0	0
Organon & Co.	Common	68622V106	1,639	54,169	SH		SOLE		54,169	0	0
Ovid Therapeutics Inc.	Sponsored ADR	690469101	1,457	372,733	SH		SOLE		372,733	0	0
Owens & Minor, Inc.	Common	690732102	11,261	266,023	SH		SOLE		266,023	0	0
PerkinElmer, Inc.	Common	714046109	5,728	37,094	SH		SOLE		37,094	0	0
Perrigo Co. plc	Shares	G97822103	2,349	51,224	SH		SOLE		51,224	0	0
Personalis, Inc.	Common	71535D106	4,547	179,731	SH		SOLE		179,731	0	0
Pfizer Inc.	Common	717081103	17,637	450,379	SH		SOLE		450,379	0	0
Physicians Realty Trust	Common	71943U104	9,156	495,733	SH		SOLE		495,733	0	0
PRA Health Sciences, Inc.	Common	69354M108	4,141	25,068	SH		SOLE		25,068	0	0
Praxis Precision Medicines, Inc.	Common	74006W108	1,371	75,000	SH		SOLE		75,000	0	0
Precision BioSciences, Inc.	Common	74019P108	789	63,001	SH		SOLE		63,001	0	0
R1 RCM Inc.	Common	749397105	4,500	202,351	SH		SOLE		202,351	0	0
Reata Pharmaceuticals, Inc.	Class A	75615P103	5,409	38,219	SH		SOLE		38,219	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	77,152	138,132	SH		SOLE		138,132	0	0
REGENXBIO Inc.	Common	75901B107	843	21,700	SH		SOLE		21,700	0	0
Replimune Group, Inc.	Common	76029N106	8,416	219,060	SH		SOLE		219,060	0	0
ResMed Inc.	Common	761152107	33,972	137,807	SH		SOLE		137,807	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	9,294	510,660	SH		SOLE		510,660	0	0
Sage Therapeutics, Inc.	Common	78667J108	6,483	114,119	SH		SOLE		114,119	0	0
Sanofi	Sponsored ADR	80105N105	4,295	81,554	SH		SOLE		81,554	0	0
Sarepta Therapeutics, Inc.	Common	803607100	15,021	193,224	SH		SOLE		193,224	0	0
Scholar Rock Holding Corp.	Common	80706P103	3,145	108,833	SH		SOLE		108,833	0	0
Seagen Inc.	Common	81181C104	33,275	210,759	SH		SOLE		210,759	0	0
Smith & Nephew plc	Shares	83175M205	4,677	107,670	SH		SOLE		107,670	0	0
Spectrum Pharmaceuticals, Inc.	Common	84763A108	430	114,670	SH		SOLE		114,670	0	0
STERIS plc	Shares	G8473T100	5,705	27,655	SH		SOLE		27,655	0	0
Stryker Corp.	Common	863667101	39,089	150,500	SH		SOLE		150,500	0	0
Sutro Biopharma, Inc.	Common	869367102	7,439	400,147	SH		SOLE		400,147	0	0
Syneos Health, Inc.	Class A	87166B102	21,803	243,633	SH		SOLE		243,633	0	0
Takeda Pharmaceutical Company Ltd.	Sponsored ADS	874060205	3,537	210,146	SH		SOLE		210,146	0	0
TCR2 Therapeutics Inc.	Common	87808K106	3,870	235,808	SH		SOLE		235,808	0	0
Teleflex Inc.	Common	879369106	884	2,200	SH		SOLE		2,200	0	0
Tetraphase Pharmaceuticals, Inc.	Common	881CVR013	5	42,965	SH		SOLE		42,965	0	0
Teva Pharmaceutical Industries Ltd.	Sponsored ADR	881624209	6,016	607,651	SH		SOLE		607,651	0	0
Theravance Biopharma, Inc.	Common	G8807B106	9,529	656,296	SH		SOLE		656,296	0	0
Thermo Fisher Scientific Inc.	Common	883556102	70,691	140,130	SH		SOLE		140,130	0	0
Travere Therapeutics, Inc.	Common	89422G107	3,106	212,869	SH		SOLE		212,869	0	0
Trillium Therapeutics Inc.	Common	89620X506	5,133	529,226	SH		SOLE		529,226	0	0
Turning Point Therapeutics, Inc.	Common	90041T108	9,310	119,324	SH		SOLE		119,324	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	12,833	134,590	SH		SOLE		134,590	0	0
uniQure N.V.	Shares	N90064101	6,958	225,921	SH		SOLE		225,921	0	0
United Therapeutics Corp.	Class B	91307C102	25,017	139,438	SH		SOLE		139,438	0	0
Unitedhealth Group Inc.	Common	91324P102	126,358	315,548	SH		SOLE		315,548	0	0
Universal Health Realty Income Trust	Shares	91359E105	693	11,258	SH		SOLE		11,258	0	0
Universal Health Services, Inc.	Class B	913903100	8,789	60,023	SH		SOLE		60,023	0	0
Vectivbio Holding AG	Ord Shares	H9060V101	1,691	145,000	SH		SOLE		145,000	0	0
Ventas, Inc.	Common	92276F100	11,883	208,108	SH		SOLE		208,108	0	0
Verona Pharma plc	Sponsored ADR	925050106	4,917	751,905	SH		SOLE		751,905	0	0
Vertex Pharmaceuticals Inc.	Common	92532F100	79,702	395,288	SH		SOLE		395,288	0	0
Vir Biotechnology, Inc.	Common	92764N102	3,849	81,400	SH		SOLE		81,400	0	0
VYNE Therapeutics Inc.	Common	92941V209	475	135,395	SH		SOLE		135,395	0	0
Waters Corp.	Common	941848103	16,695	48,306	SH		SOLE		48,306	0	0
Welltower Inc.	Common	95040Q104	16,876	203,083	SH		SOLE		203,083	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	3,147	169,030	SH		SOLE		169,030	0	0
Y-mAbs Therapeutics, Inc.	Common	984241109	6,686	197,820	SH		SOLE		197,820	0	0
Zai Lab Ltd.	ADR	98887Q104	6,641	37,523	SH		SOLE		37,523	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	35,815	222,703	SH		SOLE		222,703	0	0
Zoetis Inc.	Class A	98978V103	10,533	56,521	SH		SOLE		56,521	0	0
Zogenix, Inc.	Common	98978L204	1,538	88,977	SH		SOLE		88,977	0	0