Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
Estimated average burden
hours per response:		23.8

COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
1Life Healthcare, Inc.	Common	68269G107	245	31,266	SH		SOLE		31,266	0	0
Abbott Laboratories	Common	002824100	68,155	627,292	SH		SOLE		627,292	0	0
AbbVie Inc.	Common	00287Y109	86,818	566,842	SH		SOLE		566,842	0	0
Acadia Healthcare Company, Inc.	Common	00404A109	4,890	72,307	SH		SOLE		72,307	0	0
ACADIA Pharmaceuticals Inc.	Common	004225108	1,018	72,225	SH		SOLE		72,225	0	0
Adaptive Biotechnologies Corp.	Common	00650F109	2,732	337,722	SH		SOLE		337,722	0	0
Addus HomeCare Corp.	Common	006739106	6,965	83,632	SH		SOLE		83,632	0	0
Adicet Bio, Inc.	Common	007002108	925	63,329	SH		SOLE		63,329	0	0
Affimed N.V.	Common	N01045108	1,623	586,038	SH		SOLE		586,038	0	0
Agilent Technologies, Inc.	Common	00846U101	5,130	43,191	SH		SOLE		43,191	0	0
AlerisLife Inc.	Common	33832D205	29	24,237	SH		SOLE		24,237	0	0
Align Technology, Inc.	Common	016255101	4,472	18,894	SH		SOLE		18,894	0	0
Alkermes plc	Shares	G01767105	5,664	190,122	SH		SOLE		190,122	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	18,729	128,414	SH		SOLE		128,414	0	0
ALX Oncology Holdings Inc.	Common	00166B105	536	66,211	SH		SOLE		66,211	0	0
Amgen Inc.	Common	031162100	133,430	548,418	SH		SOLE		548,418	0	0
AMN Healthcare Services, Inc.	Common	001744101	6,714	61,201	SH		SOLE		61,201	0	0
Apellis Pharmaceuticals, Inc.	Common	03753U106	14,117	312,192	SH		SOLE		312,192	0	0
ARCA biopharma, Inc.	Common	00211Y506	81	32,461	SH		SOLE		32,461	0	0
Arcutis Biotherapeutics, Inc.	Common	03969K108	3,173	148,874	SH		SOLE		148,874	0	0
Ardelyx, Inc.	Common	039697107	318	539,408	SH		SOLE		539,408	0	0
argenx SE	Sponsored ADR	04016X101	14,570	38,456	SH		SOLE		38,456	0	0
Arrowhead Pharmaceuticals, Inc.	Common	04280A100	5,524	156,875	SH		SOLE		156,875	0	0
Arvinas, Inc.	Common	04335A105	3,620	85,997	SH		SOLE		85,997	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	6,302	67,794	SH		SOLE		67,794	0	0
Assertio Holdings, Inc.	Common	04546C205	1,211	410,575	SH		SOLE		410,575	0	0
AstraZeneca PLC	Sponsored ADR	046353108	74,312	1,124,741	SH		SOLE		1,124,741	0	0
Aurinia Pharmaceuticals Inc.	Common	05156V102	1,634	162,599	SH		SOLE		162,599	0	0
Avidity Biosciences, Inc.	Common	05370A108	1,238	85,218	SH		SOLE		85,218	0	0
Beam Therapeutics Inc.	Common	07373V105	612	15,817	SH		SOLE		15,817	0	0
Becton, Dickinson and Company	Common	075887109	18,226	73,930	SH		SOLE		73,930	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	8,257	51,018	SH		SOLE		51,018	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481404	7	6,000	SH		SOLE		6,000	0	0
Bicycle Therapeutics PLC	Sponsored ADS	088786108	337	20,065	SH		SOLE		20,065	0	0
BioCryst Pharmaceuticals, Inc.	Common	09058V103	2,935	277,434	SH		SOLE		277,434	0	0
Biogen Inc.	Common	09062X103	27,662	135,639	SH		SOLE		135,639	0	0
Biohaven Pharmaceutical Holding Company Ltd.	Common	G11196105	10,225	70,176	SH		SOLE		70,176	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	10,608	128,004	SH		SOLE		128,004	0	0
BioNTech SE	Sponsored ADS	09075V102	14,171	95,042	SH		SOLE		95,042	0	0
Black Diamond Therapeutics, Inc.	Common	09203E105	325	131,990	SH		SOLE		131,990	0	0
Blueprint Medicines Corp.	Common	09627Y109	5,613	111,118	SH		SOLE		111,118	0	0
Boston Scientific Corp.	Common	101137107	29,638	795,215	SH		SOLE		795,215	0	0
Bristol-Myers Squibb Company	Common	110122108	60,271	782,735	SH		SOLE		782,735	0	0
Caribou Biosciences, Inc.	Common	142038108	3,798	699,377	SH		SOLE		699,377	0	0
Cerevel Therapeutics Holdings, Inc.	Common	15678U128	2,331	88,173	SH		SOLE		88,173	0	0
Charles River Laboratories International, Inc.	Common	159864107	10,248	47,894	SH		SOLE		47,894	0	0
ChemoCentryx, Inc.	Common	16383L106	1,938	78,197	SH		SOLE		78,197	0	0
Cigna Corp.	Common	125523100	45,617	173,106	SH		SOLE		173,106	0	0
Cogent Biosciences, Inc.	Common	19240Q201	1,325	146,911	SH		SOLE		146,911	0	0
Community Health Systems, Inc.	Common	203668108	331	88,335	SH		SOLE		88,335	0	0
Community Healthcare Trust Inc.	Common	20369C106	540	14,900	SH		SOLE		14,900	0	0
Corbus Pharmaceuticals Holdings, Inc.	Common	21833P103	39	154,310	SH		SOLE		154,310	0	0
CRISPR Therapeutics AG	Namen AKT	H17182108	3,347	55,080	SH		SOLE		55,080	0	0
CVS Health Corp.	Common	126650100	11,472	123,803	SH		SOLE		123,803	0	0
Cytokinetics, Inc.	Common	23282W605	4,711	119,898	SH		SOLE		119,898	0	0
Danaher Corp.	Common	235851102	31,577	124,556	SH		SOLE		124,556	0	0
Denali Therapeutics, Inc.	Common	24823R105	6,546	222,420	SH		SOLE		222,420	0	0
Design Therapeutics, Inc.	Common	25056L103	1,518	108,414	SH		SOLE		108,414	0	0
Dexcom, Inc.	Common	252131107	9,680	129,884	SH		SOLE		129,884	0	0
Diversified Healthcare Trust	Common	25525P107	651	357,720	SH		SOLE		357,720	0	0
Edgewise Therapeutics, Inc.	Common	28036F105	482	60,550	SH		SOLE		60,550	0	0
Edwards Lifesciences Corp.	Common	28176E108	16,297	171,388	SH		SOLE		171,388	0	0
Eli Lilly and Company	Common	532457108	57,205	176,432	SH		SOLE		176,432	0	0
Elevance Health, Inc.	Common	036752103	7,067	14,644	SH		SOLE		14,644	0	0
Embecta Corp.	Common	29082K105	374	14,786	SH		SOLE		14,786	0	0
Endo International plc	Shares	G30401106	230	494,607	SH		SOLE		494,607	0	0
Fate Therapeutics, Inc.	Common	31189P102	784	31,652	SH		SOLE		31,652	0	0
Fulcrum Therapeutics, Inc.	Common	359616109	287	58,537	SH		SOLE		58,537	0	0
Fusion Pharmaceuticals Inc.	Common	36118A100	108	43,394	SH		SOLE		43,394	0	0
G1 Therapeutics, Inc.	Common	3621LQ109	2,094	423,869	SH		SOLE		423,869	0	0
Galera Therapeutics, Inc.	Common	36338D108	1,168	898,374	SH		SOLE		898,374	0	0
Gilead Sciences, Inc.	Common	375558103	102,034	1,650,765	SH		SOLE		1,650,765	0	0
Global Medical REIT Inc.	Common	37954A204	1,964	174,897	SH		SOLE		174,897	0	0
Guardant Health, Inc.	Common	40131M109	14,179	351,484	SH		SOLE		351,484	0	0
Harpoon Therapeutics, Inc.	Common	41358P106	496	259,910	SH		SOLE		259,910	0	0
HCA Healthcare, Inc.	Common	40412C101	20,890	124,303	SH		SOLE		124,303	0	0
Health Care Select Sector SPDR Fund	SBI Healthcare	81369Y209	14,521	113,230	SH		SOLE		113,230	0	0
Healthcare Realty Trust Inc.	Common	421946104	2,829	104,024	SH		SOLE		104,024	0	0
Healthcare Trust of America, Inc.	Common	42225P501	1,972	70,662	SH		SOLE		70,662	0	0
HealthEquity, Inc.	Common	42226A107	7,079	115,314	SH		SOLE		115,314	0	0
Healthpeak Properties, Inc.	Common	42250P103	3,897	150,392	SH		SOLE		150,392	0	0
Hologic, Inc.	Common	436440101	1,964	28,347	SH		SOLE		28,347	0	0
Horizon Therapeutics plc	Shares	G46188101	69,877	876,089	SH		SOLE		876,089	0	0
Humana Inc.	Common	444859102	29,860	63,794	SH		SOLE		63,794	0	0
Icon plc	Shares	G4705A100	17,634	81,375	SH		SOLE		81,375	0	0
I-Mab	Sponsored ADS	44975P103	1,837	162,580	SH		SOLE		162,580	0	0
IDEXX Laboratories, Inc.	Common	45168D104	18,557	52,910	SH		SOLE		52,910	0	0
Illumina, Inc.	Common	452327109	36,143	196,047	SH		SOLE		196,047	0	0
Intellia Therapeutics, Inc.	Common	45826J105	3,011	58,180	SH		SOLE		58,180	0	0
Intercept Pharmaceuticals, Inc.	Common	45845P108	719	52,067	SH		SOLE		52,067	0	0
Intra-Cellular Therapies, Inc.	Common	46116X101	13,895	243,437	SH		SOLE		243,437	0	0
Intuitive Surgical, Inc.	Common	46120E602	21,311	106,176	SH		SOLE		106,176	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	6,504	175,680	SH		SOLE		175,680	0	0
IQVIA Holdings Inc.	Common	46266C105	18,293	84,303	SH		SOLE		84,303	0	0
iTeos Therapeutics, Inc.	Common	46565G104	436	21,181	SH		SOLE		21,181	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	26,194	167,899	SH		SOLE		167,899	0	0
Johnson & Johnson	Common	478160104	91,711	516,652	SH		SOLE		516,652	0	0
Karuna Therapeutics, Inc.	Common	48576A100	10,002	79,057	SH		SOLE		79,057	0	0
Koninklijke Philips N.V.	NY Reg Shares	500472303	3,548	164,790	SH		SOLE		164,790	0	0
Laboratory Corporation of America Holdings	Common	50540R409	10,345	44,142	SH		SOLE		44,142	0	0
Lantheus Holdings, Inc.	Common	516544103	8,392	127,092	SH		SOLE		127,092	0	0
LTC Properties, Inc.	Common	502175102	6,998	182,293	SH		SOLE		182,293	0	0
McKesson Corp.	Common	58155Q103	52,429	160,722	SH		SOLE		160,722	0	0
Medical Properties Trust, Inc.	Common	58463J304	6,287	411,743	SH		SOLE		411,743	0	0
Medpace Holdings, Inc.	Common	58506Q109	1,412	9,435	SH		SOLE		9,435	0	0
Medtronic plc	Shares	G5960L103	29,274	326,172	SH		SOLE		326,172	0	0
Merck & Co., Inc.	Common	58933Y105	50,337	552,122	SH		SOLE		552,122	0	0
Mereo BioPharma Group plc	ADS	589492107	1,737	1,551,082	SH		SOLE		1,551,082	0	0
Merus N.V.	Common	N5749R100	2,157	95,290	SH		SOLE		95,290	0	0
Mirati Therapeutics, Inc.	Common	60468T105	5,624	83,784	SH		SOLE		83,784	0	0
Moderna, Inc.	Common	60770K107	46,930	328,524	SH		SOLE		328,524	0	0
Molina Healthcare, Inc.	Common	60855R100	29,383	105,085	SH		SOLE		105,085	0	0
Morphic Holding, Inc.	Common	61775R105	968	44,625	SH		SOLE		44,625	0	0
MorphoSys AG	Sponsored ADS	617760202	396	81,867	SH		SOLE		81,867	0	0
Natera, Inc.	Common	632307104	758	21,400	SH		SOLE		21,400	0	0
National Health Investors, Inc.	Common	63633D104	608	10,038	SH		SOLE		10,038	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	16,387	168,108	SH		SOLE		168,108	0	0
NexGel, Inc.	Common	65344E107	7	4,243	SH		SOLE		4,243	0	0
Nkarta, Inc.	Common	65487U108	357	28,988	SH		SOLE		28,988	0	0
Novartis AG	Sponsored ADR	66987V109	11,515	136,225	SH		SOLE		136,225	0	0
Novavax, Inc.	Common	670002401	3,281	63,800	SH		SOLE		63,800	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	14,544	130,523	SH		SOLE		130,523	0	0
Omega Healthcare Investors, Inc.	Common	681936100	8,638	306,433	SH		SOLE		306,433	0	0
Owens & Minor, Inc.	Common	690732102	9,063	288,167	SH		SOLE		288,167	0	0
Perrigo Company plc	Shares	G97822103	2,078	51,224	SH		SOLE		51,224	0	0
Pfizer Inc.	Common	717081103	59,356	1,132,103	SH		SOLE		1,132,103	0	0
Physicians Realty Trust	Common	71943U104	8,651	495,733	SH		SOLE		495,733	0	0
Praxis Precision Medicines, Inc.	Common	74006W108	184	75,000	SH		SOLE		75,000	0	0
Precision BioSciences, Inc.	Common	74019P108	359	224,534	SH		SOLE		224,534	0	0
Prometheus Biosciences, Inc.	Common	74349U108	1,389	49,195	SH		SOLE		49,195	0	0
Protagonist Therapeutics, Inc.	Common	74366E102	967	122,271	SH		SOLE		122,271	0	0
Pyxis Oncology, Inc.	Common	747324101	1,686	708,303	SH		SOLE		708,303	0	0
Qiagen N.V.	Shares	N72482123	496	10,500	SH		SOLE		10,500	0	0
R1 RCM Inc.	Common	77634L105	4,241	202,351	SH		SOLE		202,351	0	0
Rallybio Corporation	Common	75120L100	14,580	1,931,120	SH		SOLE		1,931,120	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	84,451	142,864	SH		SOLE		142,864	0	0
Repare Therapeutics Inc.	Common	760273102	408	29,150	SH		SOLE		29,150	0	0
ResMed Inc.	Common	761152107	14,884	70,999	SH		SOLE		70,999	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	7,134	510,660	SH		SOLE		510,660	0	0
Sanofi	Sponsored ADR	80105N105	6,176	123,454	SH		SOLE		123,454	0	0
Sarepta Therapeutics, Inc.	Common	803607100	15,904	212,165	SH		SOLE		212,165	0	0
Scholar Rock Holding Corp.	Common	80706P103	597	108,833	SH		SOLE		108,833	0	0
Seagen Inc.	Common	81181C104	34,536	195,183	SH		SOLE		195,183	0	0
Smith & Nephew plc	Sponsored ADR	83175M205	5,073	181,710	SH		SOLE		181,710	0	0
SPDR S&P Biotech ETF	S&P Biotech ETF	78464A870	15,534	209,154	SH		SOLE		209,154	0	0
Spectrum Pharmaceuticals, Inc.	Common	84763A108	89	114,670	SH		SOLE		114,670	0	0
STERIS plc	Shares	G8473T100	3,436	16,669	SH		SOLE		16,669	0	0
Stevanato Group Societa' Per Azioni	Ordinary Shares	T9224W109	1,126	71,190	SH		SOLE		71,190	0	0
Stryker Corp.	Common	863667101	44,894	225,678	SH		SOLE		225,678	0	0
Sutro Biopharma, Inc.	Common	869367102	854	163,924	SH		SOLE		163,924	0	0
Syndax Pharmaceuticals, Inc.	Common	87164F105	1,087	56,480	SH		SOLE		56,480	0	0
Syneos Health, Inc.	Class A	87166B102	21,715	302,945	SH		SOLE		302,945	0	0
Takeda Pharmaceutical Company Ltd.	Sponsored ADS	874060205	1,475	105,073	SH		SOLE		105,073	0	0
Teva Pharmaceutical Industries Ltd.	Sponsored ADR	881624209	3,457	459,651	SH		SOLE		459,651	0	0
Thermo Fisher Scientific Inc.	Common	883556102	53,027	97,605	SH		SOLE		97,605	0	0
Theseus Pharmaceuticals, Inc.	Common	88369M101	553	100,000	SH		SOLE		100,000	0	0
Travere Therapeutics, Inc.	Common	89422G107	6,001	247,678	SH		SOLE		247,678	0	0
TScan Therapeutics, Inc.	Common	89854M101	629	200,000	SH		SOLE		200,000	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	2,647	44,365	SH		SOLE		44,365	0	0
uniQure N.V.	Shares	N90064101	9,724	521,693	SH		SOLE		521,693	0	0
United Therapeutics Corp.	Common	91307C102	17,015	72,206	SH		SOLE		72,206	0	0
Unitedhealth Group Inc.	Common	91324P102	164,110	319,510	SH		SOLE		319,510	0	0
Universal Health Realty Income Trust	Shares	91359E105	599	11,258	SH		SOLE		11,258	0	0
Universal Health Services, Inc.	Class B	913903100	403	4,000	SH		SOLE		4,000	0	0
VectivBio Holding AG	Ordinary Shares	H9060V101	4,085	756,502	SH		SOLE		756,502	0	0
Ventas, Inc.	Common	92276F100	12,761	248,131	SH		SOLE		248,131	0	0
Verona Pharma plc	Sponsored ADR	925050106	3,150	751,905	SH		SOLE		751,905	0	0
Vertex Pharmaceuticals Inc.	Common	92532F100	101,791	361,231	SH		SOLE		361,231	0	0
VYNE Therapeutics Inc.	Common	92941V209	53	135,395	SH		SOLE		135,395	0	0
Waters Corp.	Common	941848103	1,192	3,600	SH		SOLE		3,600	0	0
Welltower Inc.	Common	95040Q104	16,724	203,083	SH		SOLE		203,083	0	0
Xencor, Inc.	Common	98401F105	6,487	236,996	SH		SOLE		236,996	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	904	29,710	SH		SOLE		29,710	0	0
Zai Lab Ltd.	ADR	98887Q104	1,502	43,300	SH		SOLE		43,300	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	14,923	142,044	SH		SOLE		142,044	0	0
ZimVie Inc.	Common	98888T107	227	14,202	SH		SOLE		14,202	0	0
Zoetis Inc.	Class A	98978V103	25,219	146,714	SH		SOLE		146,714	0	0