Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
1Life Healthcare, Inc.	Common	68269G107	536	31,266	SH		SOLE		31,266	0	0
Abbott Laboratories	Common	002824100	76,542	791,051	SH		SOLE		791,051	0	0
AbbVie Inc.	Common	00287Y109	70,707	526,842	SH		SOLE		526,842	0	0
Acadia Healthcare Company, Inc.	Common	00404A109	11,038	141,189	SH		SOLE		141,189	0	0
ACADIA Pharmaceuticals Inc.	Common	004225108	1,182	72,225	SH		SOLE		72,225	0	0
Adaptive Biotechnologies Corp.	Common	00650F109	3,007	422,281	SH		SOLE		422,281	0	0
Addus HomeCare Corp.	Common	006739106	7,965	83,632	SH		SOLE		83,632	0	0
Adicet Bio, Inc.	Common	007002108	573	40,329	SH		SOLE		40,329	0	0
Affimed N.V.	Common	N01045108	1,207	586,038	SH		SOLE		586,038	0	0
Agilent Technologies, Inc.	Common	00846U101	5,250	43,191	SH		SOLE		43,191	0	0
AlerisLife Inc.	Common	33832D205	23	24,237	SH		SOLE		24,237	0	0
Align Technology, Inc.	Common	016255101	3,913	18,894	SH		SOLE		18,894	0	0
Alkermes plc	Shares	G01767105	6,914	309,613	SH		SOLE		309,613	0	0
Allscripts Healthcare Solutions, Inc.	Common	01988P108	6,527	428,580	SH		SOLE		428,580	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	28,666	143,214	SH		SOLE		143,214	0	0
ALX Oncology Holdings Inc.	Common	00166B105	634	66,211	SH		SOLE		66,211	0	0
Amgen Inc.	Common	031162100	116,953	518,869	SH		SOLE		518,869	0	0
Apellis Pharmaceuticals, Inc.	Common	03753U106	18,173	266,076	SH		SOLE		266,076	0	0
ARCA biopharma, Inc.	Common	00211Y506	67	32,461	SH		SOLE		32,461	0	0
Arcutis Biotherapeutics, Inc.	Common	03969K108	2,845	148,874	SH		SOLE		148,874	0	0
Ardelyx, Inc.	Common	039697107	642	539,408	SH		SOLE		539,408	0	0
argenx SE	Sponsored ADR	04016X101	27,056	76,635	SH		SOLE		76,635	0	0
Arrowhead Pharmaceuticals, Inc.	Common	04280A100	5,185	156,875	SH		SOLE		156,875	0	0
Arvinas, Inc.	Common	04335A105	3,826	85,997	SH		SOLE		85,997	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	7,000	67,794	SH		SOLE		67,794	0	0
Assertio Holdings, Inc.	Common	04546C205	932	410,575	SH		SOLE		410,575	0	0
AstraZeneca PLC	Sponsored ADR	046353108	69,822	1,273,193	SH		SOLE		1,273,193	0	0
Avidity Biosciences, Inc.	Common	05370A108	1,055	64,618	SH		SOLE		64,618	0	0
Beam Therapeutics Inc.	Common	07373V105	754	15,817	SH		SOLE		15,817	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	2,825	20,952	SH		SOLE		20,952	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481404	7	6,000	SH		SOLE		6,000	0	0
Bicycle Therapeutics PLC	Sponsored ADS	088786108	2,063	88,676	SH		SOLE		88,676	0	0
BioCryst Pharmaceuticals, Inc.	Common	09058V103	4,405	349,570	SH		SOLE		349,570	0	0
Biogen Inc.	Common	09062X103	38,832	145,439	SH		SOLE		145,439	0	0
Biohaven Pharmaceutical Holding Company Ltd.	Common	G11196105	10,609	70,176	SH		SOLE		70,176	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	12,796	150,947	SH		SOLE		150,947	0	0
BioNTech SE	Sponsored ADS	09075V102	12,819	95,042	SH		SOLE		95,042	0	0
Black Diamond Therapeutics, Inc.	Common	09203E105	223	131,990	SH		SOLE		131,990	0	0
Boston Scientific Corp.	Common	101137107	30,799	795,215	SH		SOLE		795,215	0	0
Bristol-Myers Squibb Company	Common	110122108	62,522	879,476	SH		SOLE		879,476	0	0
Cardiovascular Systems, Inc.	Common	141619106	2,424	174,859	SH		SOLE		174,859	0	0
Caribou Biosciences, Inc.	Common	142038108	5,983	567,147	SH		SOLE		567,147	0	0
Cerevel Therapeutics Holdings, Inc.	Common	15678U128	4,987	176,483	SH		SOLE		176,483	0	0
Charles River Laboratories International, Inc.	Common	159864107	14,302	72,675	SH		SOLE		72,675	0	0
ChemoCentryx, Inc.	Common	16383L106	4,040	78,197	SH		SOLE		78,197	0	0
Cigna Corp.	Common	125523100	58,472	210,731	SH		SOLE		210,731	0	0
Codexis Inc	Common	192005106	419	69,125	SH		SOLE		69,125	0	0
Community Health Systems, Inc.	Common	203668108	190	88,335	SH		SOLE		88,335	0	0
Community Healthcare Trust Inc.	Common	20369C106	488	14,900	SH		SOLE		14,900	0	0
Corbus Pharmaceuticals Holdings, Inc.	Common	21833P103	25	154,310	SH		SOLE		154,310	0	0
CRISPR Therapeutics AG	Namen AKT	H17182108	3,599	55,080	SH		SOLE		55,080	0	0
CVS Health Corp.	Common	126650100	11,807	123,803	SH		SOLE		123,803	0	0
Cytokinetics, Inc.	Common	23282W605	3,640	75,139	SH		SOLE		75,139	0	0
Danaher Corp.	Common	235851102	32,172	124,556	SH		SOLE		124,556	0	0
Denali Therapeutics, Inc.	Common	24823R105	6,826	222,420	SH		SOLE		222,420	0	0
Design Therapeutics, Inc.	Common	25056L103	4,690	280,523	SH		SOLE		280,523	0	0
Dexcom, Inc.	Common	252131107	19,790	245,712	SH		SOLE		245,712	0	0
Diversified Healthcare Trust	Common	25525P107	354	357,720	SH		SOLE		357,720	0	0
Edgewise Therapeutics, Inc.	Common	28036F105	1,919	195,025	SH		SOLE		195,025	0	0
Edwards Lifesciences Corp.	Common	28176E108	14,162	171,388	SH		SOLE		171,388	0	0
Elevance Health, Inc.	Common	036752103	6,652	14,644	SH		SOLE		14,644	0	0
Eli Lilly and Company	Common	532457108	77,791	240,578	SH		SOLE		240,578	0	0
Endo International plc	Shares	G30401106	48	494,607	SH		SOLE		494,607	0	0
Fulcrum Therapeutics, Inc.	Common	36118A100	474	58,537	SH		SOLE		58,537	0	0
Fusion Pharmaceuticals Inc.	Common	36118A100	131	43,394	SH		SOLE		43,394	0	0
G1 Therapeutics, Inc.	Common	3621LQ109	5,294	423,869	SH		SOLE		423,869	0	0
Galera Therapeutics, Inc.	Common	36338D108	1,563	898,374	SH		SOLE		898,374	0	0
Gilead Sciences, Inc.	Common	375558103	100,071	1,622,165	SH		SOLE		1,622,165	0	0
Global Medical REIT Inc.	Common	37954A204	1,490	174,897	SH		SOLE		174,897	0	0
GSK PLC SPON ADR	Common	37733W204	1,232	41,852	SH		SOLE		41,852	0	0
Guardant Health, Inc.	Common	40131M109	18,630	346,084	SH		SOLE		346,084	0	0
Harpoon Therapeutics, Inc.	Common	41358P106	252	259,910	SH		SOLE		259,910	0	0
HCA Healthcare, Inc.	Common	40412C101	22,846	124,303	SH		SOLE		124,303	0	0
Health Care Select Sector SPDR Fund	SBI Healthcare	81369Y209	3,515	29,024	SH		SOLE		29,024	0	0
Healthcare Realty Trust Inc.	Common	42226K105	3,642	174,686	SH		SOLE		174,686	0	0
HealthEquity, Inc.	Common	42226A107	7,403	110,214	SH		SOLE		110,214	0	0
Healthpeak Properties, Inc.	Common	42250P103	3,447	150,392	SH		SOLE		150,392	0	0
Horizon Therapeutics plc	Common	G46188101	45,449	734,353	SH		SOLE		734,353	0	0
Humana Inc.	Common	444859102	54,828	113,004	SH		SOLE		113,004	0	0
I-Mab	Sponsored ADS	44975P103	652	162,580	SH		SOLE		162,580	0	0
Icon plc	Shares	G4705A100	1,918	10,434	SH		SOLE		10,434	0	0
IDEAYA Biosciences, Inc.	Common	45166A102	1,987	133,185	SH		SOLE		133,185	0	0
IDEXX Laboratories, Inc.	Common	45168D104	17,661	54,207	SH		SOLE		54,207	0	0
Illumina, Inc.	Common	452327109	56,272	294,943	SH		SOLE		294,943	0	0
Intellia Therapeutics, Inc.	Common	45826J105	8,633	154,269	SH		SOLE		154,269	0	0
Intercept Pharmaceuticals, Inc.	Common	45845P108	726	52,067	SH		SOLE		52,067	0	0
Intra-Cellular Therapies, Inc.	Common	46116X101	8,020	172,371	SH		SOLE		172,371	0	0
Intuitive Surgical, Inc.	Common	46120E602	19,569	104,403	SH		SOLE		104,403	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	3,885	87,840	SH		SOLE		87,840	0	0
IQVIA Holdings Inc.	Common	46266C105	12,284	67,817	SH		SOLE		67,817	0	0
Ishares Biothechnology ETF	Common	464287556	2,874	24,569	SH		SOLE		24,569	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	24,363	182,782	SH		SOLE		182,782	0	0
Johnson & Johnson	Common	478160104	128,038	783,779	SH		SOLE		783,779	0	0
Karuna Therapeutics, Inc.	Common	48576A100	5,312	23,616	SH		SOLE		23,616	0	0
Koninklijke Philips N.V.	NY Reg Shares	500472303	2,536	164,790	SH		SOLE		164,790	0	0
Laboratory Corporation of America Holdings	Common	50540R409	9,041	44,142	SH		SOLE		44,142	0	0
Lantheus Holdings, Inc.	Common	516544103	16,118	229,179	SH		SOLE		229,179	0	0
LTC Properties, Inc.	Common	502175102	6,827	182,293	SH		SOLE		182,293	0	0
McKesson Corp.	Common	58155Q103	11,439	33,657	SH		SOLE		33,657	0	0
Medical Properties Trust, Inc.	Common	58463J304	4,883	411,743	SH		SOLE		411,743	0	0
Medpace Holdings, Inc.	Common	58506Q109	1,483	9,435	SH		SOLE		9,435	0	0
Medtronic plc	Shares	G5960L103	26,338	326,172	SH		SOLE		326,172	0	0
Merck & Co., Inc.	Common	58933Y105	47,549	552,122	SH		SOLE		552,122	0	0
Mereo BioPharma Group plc	ADS	589492107	1,336	1,551,082	SH		SOLE		1,551,082	0	0
Merus N.V.	Common	N5749R100	3,389	169,207	SH		SOLE		169,207	0	0
Mirati Therapeutics, Inc.	Common	60468T105	8,548	122,390	SH		SOLE		122,390	0	0
Moderna, Inc.	Common	60770K107	37,240	314,924	SH		SOLE		314,924	0	0
Molina Healthcare, Inc.	Common	60855R100	39,427	119,535	SH		SOLE		119,535	0	0
MoonLake Immunotherapeutics	Common	61559X104	2,388	300,000	SH		SOLE		300,000	0	0
Morphic Holding, Inc.	Common	61775R105	1,263	44,625	SH		SOLE		44,625	0	0
MorphoSys AG	Sponsored ADS	617760202	412	81,867	SH		SOLE		81,867	0	0
Natera, Inc.	Common	632307104	938	21,400	SH		SOLE		21,400	0	0
National Health Investors, Inc.	Common	63633D104	567	10,038	SH		SOLE		10,038	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	17,855	168,108	SH		SOLE		168,108	0	0
NexGel, Inc.	Common	65344E107	6	4,243	SH		SOLE		4,243	0	0
Nkarta, Inc.	Common	65487U108	381	28,988	SH		SOLE		28,988	0	0
Novartis AG	Sponsored ADR	66987V109	10,354	136,225	SH		SOLE		136,225	0	0
Novavax, Inc.	Common	670002401	1,161	63,800	SH		SOLE		63,800	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	13,004	130,523	SH		SOLE		130,523	0	0
Omega Healthcare Investors, Inc.	Common	681936100	9,037	306,433	SH		SOLE		306,433	0	0
Option Care Health, Inc.	Common	68404L201	2,045	64,975	SH		SOLE		64,975	0	0
Owens & Minor, Inc.	Common	690732102	5,425	225,117	SH		SOLE		225,117	0	0
Perrigo Company plc	Shares	G97822103	1,827	51,224	SH		SOLE		51,224	0	0
Pfizer Inc.	Common	717081103	49,541	1,132,103	SH		SOLE		1,132,103	0	0
Physicians Realty Trust	Common	71943U104	2,538	168,741	SH		SOLE		168,741	0	0
Praxis Precision Medicines, Inc.	Common	74006W108	170	75,000	SH		SOLE		75,000	0	0
Precision BioSciences, Inc.	Common	74019P108	292	224,534	SH		SOLE		224,534	0	0
Prometheus Biosciences, Inc.	Common	74349U108	1,859	31,505	SH		SOLE		31,505	0	0
Protagonist Therapeutics, Inc.	Common	74366E106	1,031	122,271	SH		SOLE		122,271	0	0
Pyxis Oncology, Inc.	Common	747324101	1,395	708,303	SH		SOLE		708,303	0	0
R1 RCM Inc.	Common	77634L105	3,750	202,351	SH		SOLE		202,351	0	0
Rallybio Corporation	Common	75120L100	25,191	1,740,931	SH		SOLE		1,740,931	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	75,130	109,062	SH		SOLE		109,062	0	0
Repare Therapeutics Inc.	Common	760273102	354	29,150	SH		SOLE		29,150	0	0
ResMed Inc.	Common	761152107	13,251	60,699	SH		SOLE		60,699	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	6,700	510,660	SH		SOLE		510,660	0	0
Sanofi	Sponsored ADR	80105N105	4,694	123,454	SH		SOLE		123,454	0	0
Sarepta Therapeutics, Inc.	Common	803607100	18,345	165,959	SH		SOLE		165,959	0	0
Scholar Rock Holding Corp.	Common	80706P103	754	108,833	SH		SOLE		108,833	0	0
Seagen Inc.	Common	81181C104	7,305	53,387	SH		SOLE		53,387	0	0
Smith & Nephew plc	Sponsored ADR	83175M205	4,219	181,710	SH		SOLE		181,710	0	0
SPDR S&P Biotech ETF	S&P Biotech ETF	78464A870	11,714	147,677	SH		SOLE		147,677	0	0
Spectrum Pharmaceuticals, Inc.	Common	84763A108	49	114,670	SH		SOLE		114,670	0	0
STERIS plc	Shares	G8473T100	2,772	16,669	SH		SOLE		16,669	0	0
Stevanato Group Societa' Per Azioni	Ordinary Shares	T9224W109	1,206	71,190	SH		SOLE		71,190	0	0
Stryker Corp.	Common	863667101	39,197	193,528	SH		SOLE		193,528	0	0
Sutro Biopharma, Inc.	Common	869367102	910	163,924	SH		SOLE		163,924	0	0
Takeda Pharmaceutical Company Ltd.	Sponsored ADS	874060205	1,363	105,073	SH		SOLE		105,073	0	0
Terumo Corp.	Common	688507070	487	17,288	SH		SOLE		17,288	0	0
Teva Pharmaceutical Industries Ltd.	Sponsored ADR	881624209	3,709	459,651	SH		SOLE		459,651	0	0
Thermo Fisher Scientific Inc.	Common	883556102	47,526	93,705	SH		SOLE		93,705	0	0
Theseus Pharmaceuticals, Inc.	Common	88369M101	580	100,000	SH		SOLE		100,000	0	0
Travere Therapeutics, Inc.	Common	89422G107	6,103	247,678	SH		SOLE		247,678	0	0
TScan Therapeutics, Inc.	Common	89854M101	610	200,000	SH		SOLE		200,000	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	2,777	67,065	SH		SOLE		67,065	0	0
uniQure N.V.	Shares	N90064101	9,787	521,693	SH		SOLE		521,693	0	0
United Therapeutics Corp.	Common	91307C102	24,576	117,377	SH		SOLE		117,377	0	0
Unitedhealth Group Inc.	Common	91324P102	138,404	274,046	SH		SOLE		274,046	0	0
Universal Health Realty Income Trust	Common	91359E105	486	11,258	SH		SOLE		11,258	0	0
VectivBio Holding AG	Common	H9060V101	4,539	756,502	SH		SOLE		756,502	0	0
Ventas, Inc.	Common	92276F100	2,679	66,681	SH		SOLE		66,681	0	0
Vertex Pharmaceuticals Inc.	Common	92532F100	90,743	313,403	SH		SOLE		313,403	0	0
VYNE Therapeutics Inc.	Common	92941V209	30	135,395	SH		SOLE		135,395	0	0
Welltower Inc.	Common	95040Q104	2,668	41,484	SH		SOLE		41,484	0	0
Xencor, Inc.	Common	98401F105	5,205	200,328	SH		SOLE		200,328	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	2,229	61,733	SH		SOLE		61,733	0	0
Zai Lab Ltd.	ADR	98887Q104	1,481	43,300	SH		SOLE		43,300	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	27,065	258,868	SH		SOLE		258,868	0	0
Zoetis Inc.	Class A	98978V103	20,303	136,914	SH		SOLE		136,914	0	0