Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
1Life Healthcare, Inc.	Common	68269G107	522,455	31,266	SH		SOLE		522,455	0	0
Abbott Laboratories	Common	002824100	76,090,069	693,051	SH		SOLE		76,090,069	0	0
AbbVie Inc.	Common	00287Y109	77,304,851	478,342	SH		SOLE		77,304,851	0	0
Acadia Healthcare Company, Inc.	Common	00404A109	11,622,678	141,189	SH		SOLE		11,622,678	0	0
ACADIA Pharmaceuticals Inc.	Common	004225108	1,149,822	72,225	SH		SOLE		1,149,822	0	0
Adaptive Biotechnologies Corp.	Common	00650F109	3,226,227	422,281	SH		SOLE		3,226,227	0	0
Addus HomeCare Corp.	Common	006739106	4,216,386	42,380	SH		SOLE		4,216,386	0	0
Adicet Bio, Inc.	Common	007002108	360,541	40,329	SH		SOLE		360,541	0	0
Affimed N.V.	Common	N01045108	726,687	586,038	SH		SOLE		726,687	0	0
Agilent Technologies, Inc.	Common	00846U101	6,463,533	43,191	SH		SOLE		6,463,533	0	0
AlerisLife Inc.	Common	33832D205	13,330	24,237	SH		SOLE		13,330	0	0
Align Technology, Inc.	Common	016255101	10,718,782	50,824	SH		SOLE		10,718,782	0	0
Alkermes plc	Shares	G01767105	8,090,188	309,613	SH		SOLE		8,090,188	0	0
Allscripts Healthcare Solutions, Inc.	Common	01988P108	7,560,151	428,580	SH		SOLE		7,560,151	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	34,034,807	143,214	SH		SOLE		34,034,807	0	0
ALX Oncology Holdings Inc.	Common	00166B105	746,198	66,211	SH		SOLE		746,198	0	0
Amerisourcebergen Corp.	Common	03073E105	3,383,301	20,417	SH		SOLE		3,383,301	0	0
Amgen Inc.	Common	031162100	133,598,665	508,676	SH		SOLE		133,598,665	0	0
Apellis Pharmaceuticals, Inc.	Common	03753U106	3,434,888	66,426	SH		SOLE		3,434,888	0	0
ARCA biopharma, Inc.	Common	00211Y506	76,608	32,461	SH		SOLE		76,608	0	0
Arcutis Biotherapeutics, Inc.	Common	03969K108	2,203,335	148,874	SH		SOLE		2,203,335	0	0
Ardelyx, Inc.	Common	039697107	1,537,313	539,408	SH		SOLE		1,537,313	0	0
argenx SE	Sponsored ADR	04016X101	31,829,675	84,021	SH		SOLE		31,829,675	0	0
Arrowhead Pharmaceuticals, Inc.	Common	04280A100	4,073,116	100,422	SH		SOLE		4,073,116	0	0
Arvinas, Inc.	Common	04335A105	1,470,962	42,998	SH		SOLE		1,470,962	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	15,118,595	123,791	SH		SOLE		15,118,595	0	0
Assertio Holdings, Inc.	Common	04546C205	1,765,473	410,575	SH		SOLE		1,765,473	0	0
AstraZeneca PLC	Sponsored ADR	046353108	69,308,889	1,022,255	SH		SOLE		69,308,889	0	0
Avantor, Inc.	Common	05352A100	9,690,602	459,488	SH		SOLE		9,690,602	0	0
Beam Therapeutics Inc.	Common	07373V105	618,603	15,817	SH		SOLE		618,603	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	4,608,183	20,952	SH		SOLE		4,608,183	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481404	4,320	6,000	SH		SOLE		4,320	0	0
Bicycle Therapeutics PLC	Sponsored ADS	088786108	2,624,810	88,676	SH		SOLE		2,624,810	0	0
BioCryst Pharmaceuticals, Inc.	Common	09058V103	7,722,653	672,705	SH		SOLE		7,722,653	0	0
Biogen Inc.	Common	09062X103	54,118,476	195,430	SH		SOLE		54,118,476	0	0
Biohaven Ltd.	Common	G1110E107	487,008	35,087	SH		SOLE		487,008	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	23,884,457	230,790	SH		SOLE		23,884,457	0	0
BioNTech SE	Sponsored ADS	09075V102	15,601,549	103,858	SH		SOLE		15,601,549	0	0
Black Diamond Therapeutics, Inc.	Common	09203E105	237,582	131,990	SH		SOLE		237,582	0	0
Blueprint Medicines Corp.	Common	09627Y109	2,966,375	67,710	SH		SOLE		2,966,375	0	0
Boston Scientific Corp.	Common	101137107	35,027,084	757,015	SH		SOLE		35,027,084	0	0
Bristol-Myers Squibb Company	Common	110122108	49,467,712	687,529	SH		SOLE		49,467,712	0	0
Cardiovascular Systems, Inc.	Common	141619106	2,381,580	174,859	SH		SOLE		2,381,580	0	0
Caribou Biosciences, Inc.	Common	142038108	3,561,683	567,147	SH		SOLE		3,561,683	0	0
Catalent, Inc.	Common	148806102	5,668,874	125,947	SH		SOLE		5,668,874	0	0
Cerevel Therapeutics Holdings, Inc.	Common	15678U128	5,566,274	176,483	SH		SOLE		5,566,274	0	0
Charles River Laboratories International, Inc.	Common	159864107	15,835,883	72,675	SH		SOLE		15,835,883	0	0
Cigna Corp.	Common	125523100	60,512,956	182,631	SH		SOLE		60,512,956	0	0
Codexis Inc	Common	192005106	322,123	69,125	SH		SOLE		322,123	0	0
Community Health Systems, Inc.	Common	203668108	381,607	88,335	SH		SOLE		381,607	0	0
Community Healthcare Trust Inc.	Common	20369C106	533,420	14,900	SH		SOLE		533,420	0	0
Corbus Pharmaceuticals Holdings, Inc.	Common	21833P103	17,051	154,310	SH		SOLE		17,051	0	0
Crinetics Pharmaceuticals, Inc.	Common	22663K107	839,256	45,861	SH		SOLE		839,256	0	0
CRISPR Therapeutics AG	Namen AKT	H17182108	2,239,002	55,080	SH		SOLE		2,239,002	0	0
CVS Health Corp.	Common	126650100	8,724,541	93,621	SH		SOLE		8,724,541	0	0
Cytokinetics, Inc.	Common	23282W605	3,442,869	75,139	SH		SOLE		3,442,869	0	0
Danaher Corp.	Common	235851102	28,052,240	105,690	SH		SOLE		28,052,240	0	0
Denali Therapeutics, Inc.	Common	24823R105	7,578,781	272,520	SH		SOLE		7,578,781	0	0
Dexcom, Inc.	Common	252131107	24,688,019	218,015	SH		SOLE		24,688,019	0	0
Diversified Healthcare Trust	Common	25525P107	231,373	357,720	SH		SOLE		231,373	0	0
Edgewise Therapeutics, Inc.	Common	28036F105	1,743,524	195,025	SH		SOLE		1,743,524	0	0
Edwards Lifesciences Corp.	Common	28176E108	12,787,259	171,388	SH		SOLE		12,787,259	0	0
Elevance Health, Inc.	Common	036752103	7,511,933	14,644	SH		SOLE		7,511,933	0	0
Eli Lilly and Company	Common	532457108	105,697,395	288,917	SH		SOLE		105,697,395	0	0
Fulcrum Therapeutics, Inc.	Common	359616109	426,149	58,537	SH		SOLE		426,149	0	0
Fusion Pharmaceuticals Inc.	Common	36118A100	136,691	43,394	SH		SOLE		136,691	0	0
G1 Therapeutics, Inc.	Common	3621LQ109	2,301,609	423,869	SH		SOLE		2,301,609	0	0
Galera Therapeutics, Inc.	Common	36338D108	1,338,577	898,374	SH		SOLE		1,338,577	0	0
Gilead Sciences, Inc.	Common	375558103	129,671,274	1,510,440	SH		SOLE		129,671,274	0	0
Global Medical REIT Inc.	Common	37954A204	1,658,024	174,897	SH		SOLE		1,658,024	0	0
GSK plc ADR	Sponsored ADR	37733W204	1,470,679	41,852	SH		SOLE		1,470,679	0	0
Guardant Health, Inc.	Common	40131M109	12,843,405	472,184	SH		SOLE		12,843,405	0	0
Harpoon Therapeutics, Inc.	Common	41358P106	188,617	259,910	SH		SOLE		188,617	0	0
HCA Healthcare, Inc.	Common	40412C101	25,196,520	105,003	SH		SOLE		25,196,520	0	0
Healthcare Realty Trust Inc.	Common	42226K105	3,366,199	174,686	SH		SOLE		3,366,199	0	0
HealthEquity, Inc.	Common	42226A107	6,793,591	110,214	SH		SOLE		6,793,591	0	0
Healthpeak Properties, Inc.	Common	42250P103	3,770,327	150,392	SH		SOLE		3,770,327	0	0
Horizon Therapeutics plc	Common	G46188101	47,233,031	415,053	SH		SOLE		47,233,031	0	0
Humana Inc.	Common	444859102	39,803,821	77,713	SH		SOLE		39,803,821	0	0
I-Mab	Sponsored ADS	44975P103	679,584	162,580	SH		SOLE		679,584	0	0
Icon plc	Shares	G4705A100	1,813,130	9,334	SH		SOLE		1,813,130	0	0
IDEAYA Biosciences, Inc.	Common	45166A102	2,419,971	133,185	SH		SOLE		2,419,971	0	0
IDEXX Laboratories, Inc.	Common	45168D104	27,767,797	68,065	SH		SOLE		27,767,797	0	0
Illumina, Inc.	Common	452327109	64,695,508	319,958	SH		SOLE		64,695,508	0	0
Intellia Therapeutics, Inc.	Common	45826J105	5,382,445	154,269	SH		SOLE		5,382,445	0	0
Intercept Pharmaceuticals, Inc.	Common	45845P108	644,069	52,067	SH		SOLE		644,069	0	0
Intra-Cellular Therapies, Inc.	Common	46116X101	9,121,873	172,371	SH		SOLE		9,121,873	0	0
Intuitive Surgical, Inc.	Common	46120E602	29,899,638	112,680	SH		SOLE		29,899,638	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	3,317,717	87,840	SH		SOLE		3,317,717	0	0
IQVIA Holdings Inc.	Common	46266C105	12,932,042	63,117	SH		SOLE		12,932,042	0	0
Ishares Biothechnology ETF	Common	464287556	3,225,664	24,569	SH		SOLE		3,225,664	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	29,119,000	182,782	SH		SOLE		29,119,000	0	0
Johnson & Johnson	Common	478160104	112,999,295	639,679	SH		SOLE		112,999,295	0	0
Karuna Therapeutics, Inc.	Common	48576A100	10,503,318	53,452	SH		SOLE		10,503,318	0	0
Koninklijke Philips N.V.	NY Reg Shares	500472303	1,646,801	109,860	SH		SOLE		1,646,801	0	0
Kura Oncology, Inc.	Common	50127T109	3,515,517	283,281	SH		SOLE		3,515,517	0	0
Laboratory Corporation of America Holdings	Common	50540R409	10,394,558	44,142	SH		SOLE		10,394,558	0	0
Lantheus Holdings, Inc.	Common	516544103	17,472,757	342,872	SH		SOLE		17,472,757	0	0
LTC Properties, Inc.	Common	502175102	6,476,870	182,293	SH		SOLE		6,476,870	0	0
Mallinckrodt plc	Shares	G5890A102	271,622	35,048	SH		SOLE		271,622	0	0
McKesson Corp.	Common	58155Q103	24,928,600	66,455	SH		SOLE		24,928,600	0	0
Medical Properties Trust, Inc.	Common	58463J304	4,586,817	411,743	SH		SOLE		4,586,817	0	0
Medpace Holdings, Inc.	Common	58506Q109	2,004,088	9,435	SH		SOLE		2,004,088	0	0
Medtronic plc	Shares	G5960L103	25,350,088	326,172	SH		SOLE		25,350,088	0	0
Merck & Co., Inc.	Common	58933Y105	61,257,936	552,122	SH		SOLE		61,257,936	0	0
Mereo BioPharma Group plc	ADS	589492107	1,163,312	1,551,082	SH		SOLE		1,163,312	0	0
Merus N.V.	Common	N5749R100	1,428,268	92,325	SH		SOLE		1,428,268	0	0
Mirati Therapeutics, Inc.	Common	60468T105	2,967,352	65,490	SH		SOLE		2,967,352	0	0
Moderna, Inc.	Common	60770K107	47,586,188	264,927	SH		SOLE		47,586,188	0	0
Molina Healthcare, Inc.	Common	60855R100	24,309,145	73,615	SH		SOLE		24,309,145	0	0
MoonLake Immunotherapeutics AG	Common	61559X104	3,150,000	300,000	SH		SOLE		3,150,000	0	0
Morphic Holding, Inc.	Common	61775R105	1,193,719	44,625	SH		SOLE		1,193,719	0	0
MorphoSys AG	Sponsored ADS	617760202	293,084	81,867	SH		SOLE		293,084	0	0
Natera, Inc.	Common	632307104	1,979,256	49,272	SH		SOLE		1,979,256	0	0
National Health Investors, Inc.	Common	63633D104	524,184	10,038	SH		SOLE		524,184	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	13,485,732	112,908	SH		SOLE		13,485,732	0	0
NexGel, Inc.	Common	65344E107	5,304	4,243	SH		SOLE		5,304	0	0
Nkarta, Inc.	Common	65487U108	173,638	28,988	SH		SOLE		173,638	0	0
Novartis AG	Sponsored ADR	66987V109	12,358,332	136,225	SH		SOLE		12,358,332	0	0
Novavax, Inc.	Common	670002401	655,864	63,800	SH		SOLE		655,864	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	17,664,983	130,523	SH		SOLE		17,664,983	0	0
Omega Healthcare Investors, Inc.	Common	681936100	8,564,802	306,433	SH		SOLE		8,564,802	0	0
Option Care Health, Inc.	Common	68404L201	1,955,098	64,975	SH		SOLE		1,955,098	0	0
Perrigo Company plc	Shares	G97822103	1,746,226	51,224	SH		SOLE		1,746,226	0	0
Pfizer Inc.	Common	717081103	74,665,391	1,457,170	SH		SOLE		74,665,391	0	0
Physicians Realty Trust	Common	71943U104	2,441,682	168,741	SH		SOLE		2,441,682	0	0
Pliant Therapeutics, Inc.	Common	729139105	681,054	35,233	SH		SOLE		681,054	0	0
Praxis Precision Medicines, Inc.	Common	74006W108	178,500	75,000	SH		SOLE		178,500	0	0
Precision BioSciences, Inc.	Common	74019P108	267,195	224,534	SH		SOLE		267,195	0	0
Prometheus Biosciences, Inc.	Common	74349U108	4,206,070	38,237	SH		SOLE		4,206,070	0	0
Protagonist Therapeutics, Inc.	Common	74366E102	1,333,977	122,271	SH		SOLE		1,333,977	0	0
Pyxis Oncology, Inc.	Common	747324101	949,126	708,303	SH		SOLE		949,126	0	0
R1 RCM Inc.	Common	77634L105	2,215,743	202,351	SH		SOLE		2,215,743	0	0
Rallybio Corporation	Common	75120L100	11,346,830	1,727,067	SH		SOLE		11,346,830	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	87,200,724	120,862	SH		SOLE		87,200,724	0	0
Repare Therapeutics Inc.	Common	760273102	428,797	29,150	SH		SOLE		428,797	0	0
ResMed Inc.	Common	761152107	12,633,283	60,699	SH		SOLE		12,633,283	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	6,347,504	510,660	SH		SOLE		6,347,504	0	0
Sanofi	Sponsored ADR	80105N105	5,978,877	123,454	SH		SOLE		5,978,877	0	0
Sarepta Therapeutics, Inc.	Common	803607100	18,265,467	140,959	SH		SOLE		18,265,467	0	0
Scholar Rock Holding Corp.	Common	80706P103	984,939	108,833	SH		SOLE		984,939	0	0
Seagen Inc.	Common	81181C104	14,420,621	112,214	SH		SOLE		14,420,621	0	0
Smith & Nephew plc	Sponsored ADR	83175M205	4,886,182	181,710	SH		SOLE		4,886,182	0	0
SPDR S&P Biotech ETF	S&P Biotech ETF	78464A870	12,257,191	147,677	SH		SOLE		12,257,191	0	0
Spectrum Pharmaceuticals, Inc.	Common	84763A108	42,256	114,670	SH		SOLE		42,256	0	0
STERIS plc	Shares	G8473T100	3,078,598	16,669	SH		SOLE		3,078,598	0	0
Stevanato Group Societa' Per Azioni	Ordinary Shares	T9224W109	1,279,284	71,190	SH		SOLE		1,279,284	0	0
Stryker Corp.	Common	863667101	40,127,655	164,128	SH		SOLE		40,127,655	0	0
Sutro Biopharma, Inc.	Common	869367102	1,192,050	147,531	SH		SOLE		1,192,050	0	0
Syndax Pharmaceuticals, Inc.	Common	87164F105	2,995,898	117,717	SH		SOLE		2,995,898	0	0
Takeda Pharmaceutical Company Ltd.	Sponsored ADS	874060205	1,639,139	105,073	SH		SOLE		1,639,139	0	0
Teva Pharmaceutical Industries Ltd.	Sponsored ADR	881624209	4,192,017	459,651	SH		SOLE		4,192,017	0	0
Thermo Fisher Scientific Inc.	Common	883556102	51,602,406	93,705	SH		SOLE		51,602,406	0	0
Theseus Pharmaceuticals, Inc.	Common	88369M101	498,000	100,000	SH		SOLE		498,000	0	0
Travere Therapeutics, Inc.	Common	89422G107	8,801,476	418,520	SH		SOLE		8,801,476	0	0
TScan Therapeutics, Inc.	Common	89854M101	326,000	200,000	SH		SOLE		326,000	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	3,107,121	67,065	SH		SOLE		3,107,121	0	0
uniQure N.V.	Shares	N90064101	14,790,951	652,446	SH		SOLE		14,790,951	0	0
United Therapeutics Corp.	Common	91307C102	32,001,763	115,077	SH		SOLE		32,001,763	0	0
Unitedhealth Group Inc.	Common	91324P102	143,438,078	270,546	SH		SOLE		143,438,078	0	0
Universal Health Realty Income Trust	Common	91359E105	537,344	11,258	SH		SOLE		537,344	0	0
Vaxcyte, Inc.	Common	92243G108	239,750	5,000	SH		SOLE		239,750	0	0
VectivBio Holding AG	Common	H9060V101	6,351,631	737,704	SH		SOLE		6,351,631	0	0
Ventas, Inc.	Common	92276F100	3,003,979	66,681	SH		SOLE		3,003,979	0	0
Vertex Pharmaceuticals Inc.	Common	92532F100	95,396,452	330,343	SH		SOLE		95,396,452	0	0
VYNE Therapeutics Inc.	Common	92941V209	20,309	135,395	SH		SOLE		20,309	0	0
Welltower Inc.	Common	95040Q104	2,719,276	41,484	SH		SOLE		2,719,276	0	0
Xencor, Inc.	Common	98401F105	5,216,541	200,328	SH		SOLE		5,216,541	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	3,300,843	83,714	SH		SOLE		3,300,843	0	0
Zai Lab Ltd.	ADR	98887Q104	1,329,310	43,300	SH		SOLE		1,329,310	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	33,005,670	258,868	SH		SOLE		33,005,670	0	0
Zoetis Inc.	Class A	98978V103	20,064,747	136,914	SH		SOLE		20,064,747	0	0