Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
89bio, Inc.	Common	282559103	1,612,827	105,898	SH		SOLE		1,612,827	0	0
Abbott Laboratories	Common	002824100	63,171,557	623,855	SH		SOLE		63,171,557	0	0
AbbVie Inc.	Common	00287Y109	81,533,533	511,599	SH		SOLE		81,533,533	0	0
Acadia Healthcare Company, Inc.	Common	00404A109	13,473,686	186,487	SH		SOLE		13,473,686	0	0
Adaptive Biotechnologies Corp.	Common	00650F109	3,728,741	422,281	SH		SOLE		3,728,741	0	0
Addus HomeCare Corp.	Common	006739106	4,524,489	42,380	SH		SOLE		4,524,489	0	0
Adicet Bio, Inc.	Common	007002108	232,295	40,329	SH		SOLE		232,295	0	0
Affimed N.V.	Common	N01045108	436,950	586,038	SH		SOLE		436,950	0	0
Agilent Technologies, Inc.	Common	00846U101	5,975,043	43,191	SH		SOLE		5,975,043	0	0
Align Technology, Inc.	Common	016255101	2,313,920	6,925	SH		SOLE		2,313,920	0	0
Alkermes plc	Shares	G01767105	8,727,990	309,613	SH		SOLE		8,727,990	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	28,688,628	143,214	SH		SOLE		28,688,628	0	0
Altimmune, Inc.	Common	02155H200	316,500	75,000	SH		SOLE		316,500	0	0
ALX Oncology Holdings Inc.	Common	00166B105	299,274	66,211	SH		SOLE		299,274	0	0
Amedisys, Inc.	Common	023436108	5,071,199	68,949	SH		SOLE		5,071,199	0	0
Amerisourcebergen Corp.	Common	03073E105	3,268,966	20,417	SH		SOLE		3,268,966	0	0
Amgen Inc.	Common	031162100	134,398,253	555,939	SH		SOLE		134,398,253	0	0
Apellis Pharmaceuticals, Inc.	Common	03753U106	8,912,779	135,124	SH		SOLE		8,912,779	0	0
ARCA biopharma, Inc.	Common	00211Y506	64,597	32,461	SH		SOLE		64,597	0	0
Arcus Biosciences, Inc.	Common	03969F109	598,983	32,839	SH		SOLE		598,983	0	0
Arcutis Biotherapeutics, Inc.	Common	03969K108	1,637,614	148,874	SH		SOLE		1,637,614	0	0
Ardelyx, Inc.	Common	039697107	2,583,764	539,408	SH		SOLE		2,583,764	0	0
argenx SE	Sponsored ADR	04016X101	32,902,540	88,310	SH		SOLE		32,902,540	0	0
Arrowhead Pharmaceuticals, Inc.	Common	04280A100	2,550,719	100,422	SH		SOLE		2,550,719	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	13,272,871	123,791	SH		SOLE		13,272,871	0	0
Assertio Holdings, Inc.	Common	04546C205	2,615,363	410,575	SH		SOLE		2,615,363	0	0
AstraZeneca PLC	Sponsored ADR	046353108	68,900,808	992,664	SH		SOLE		68,900,808	0	0
Avantor, Inc.	Common	05352A100	9,713,576	459,488	SH		SOLE		9,713,576	0	0
Baxter International, Inc.	Common	071813109	2,730,175	67,312	SH		SOLE		2,730,175	0	0
Beam Therapeutics Inc.	Common	07373V105	484,317	15,817	SH		SOLE		484,317	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	4,515,785	20,952	SH		SOLE		4,515,785	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481404	1,980	6,000	SH		SOLE		1,980	0	0
Bicycle Therapeutics PLC	Sponsored ADS	088786108	1,886,139	88,676	SH		SOLE		1,886,139	0	0
BioCryst Pharmaceuticals, Inc.	Common	09058V103	4,207,764	504,528	SH		SOLE		4,207,764	0	0
Biogen Inc.	Common	09062X103	66,984,656	240,926	SH		SOLE		66,984,656	0	0
Biohaven Ltd.	Common	G1110E107	479,288	35,087	SH		SOLE		479,288	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	29,180,654	300,089	SH		SOLE		29,180,654	0	0
BioNTech SE	Sponsored ADS	09075V102	12,937,591	103,858	SH		SOLE		12,937,591	0	0
Black Diamond Therapeutics, Inc.	Common	09203E105	249,461	131,990	SH		SOLE		249,461	0	0
Blueprint Medicines Corp.	Common	09627Y109	3,046,273	67,710	SH		SOLE		3,046,273	0	0
Boston Scientific Corp.	Common	101137107	28,316,480	565,990	SH		SOLE		28,316,480	0	0
Bridgebio Pharma, Inc.	Common	10806X102	2,502,270	150,921	SH		SOLE		2,502,270	0	0
Bristol-Myers Squibb Company	Common	110122108	46,007,701	663,796	SH		SOLE		46,007,701	0	0
Cardiovascular Systems, Inc.	Common	141619106	3,472,700	174,859	SH		SOLE		3,472,700	0	0
Caribou Biosciences, Inc.	Common	142038108	3,011,551	567,147	SH		SOLE		3,011,551	0	0
Catalent, Inc.	Common	148806102	3,246,468	49,406	SH		SOLE		3,246,468	0	0
Cerevel Therapeutics Holdings, Inc.	Common	15678U128	4,304,420	176,483	SH		SOLE		4,304,420	0	0
Charles River Laboratories International, Inc.	Common	159864107	23,831,511	118,083	SH		SOLE		23,831,511	0	0
Chinook Therapeutics, Inc.	Common	16961L106	1,933,025	83,500	SH		SOLE		1,933,025	0	0
The Cigna Group	Common	125523100	46,667,699	182,631	SH		SOLE		46,667,699	0	0
Codexis Inc	Common	192005106	286,178	69,125	SH		SOLE		286,178	0	0
Community Health Systems, Inc.	Common	203668108	432,842	88,335	SH		SOLE		432,842	0	0
Community Healthcare Trust Inc.	Common	20369C106	545,340	14,900	SH		SOLE		545,340	0	0
Corbus Pharmaceuticals Holdings, Inc.	Common	21833P301	37,390	5,143	SH		SOLE		37,390	0	0
Crinetics Pharmaceuticals, Inc.	Common	22663K107	1,261,176	78,529	SH		SOLE		1,261,176	0	0
CRISPR Therapeutics AG	Namen AKT	H17182108	2,491,268	55,080	SH		SOLE		2,491,268	0	0
CVS Health Corp.	Common	126650100	6,956,977	93,621	SH		SOLE		6,956,977	0	0
Cytokinetics, Inc.	Common	23282W605	7,707,490	219,025	SH		SOLE		7,707,490	0	0
Danaher Corp.	Common	235851102	26,638,108	105,690	SH		SOLE		26,638,108	0	0
Denali Therapeutics, Inc.	Common	24823R105	7,484,060	324,829	SH		SOLE		7,484,060	0	0
Dexcom, Inc.	Common	252131107	26,575,826	228,747	SH		SOLE		26,575,826	0	0
Diversified Healthcare Trust	Common	25525P107	482,922	357,720	SH		SOLE		482,922	0	0
Edgewise Therapeutics, Inc.	Common	28036F105	1,300,817	195,025	SH		SOLE		1,300,817	0	0
Edwards Lifesciences Corp.	Common	28176E108	14,158,909	171,146	SH		SOLE		14,158,909	0	0
Elevance Health, Inc.	Common	036752103	52,450,527	114,070	SH		SOLE		52,450,527	0	0
Eli Lilly and Company	Common	532457108	99,219,876	288,917	SH		SOLE		99,219,876	0	0
Exelixis, Inc.	Common	30161Q104	14,104,063	726,639	SH		SOLE		14,104,063	0	0
Fulcrum Therapeutics, Inc.	Common	359616109	166,830	58,537	SH		SOLE		166,830	0	0
Fusion Pharmaceuticals Inc.	Common	36118A100	163,595	43,394	SH		SOLE		163,595	0	0
G1 Therapeutics, Inc.	Common	3621LQ109	1,135,969	423,869	SH		SOLE		1,135,969	0	0
Galera Therapeutics, Inc.	Common	36338D108	2,299,837	898,374	SH		SOLE		2,299,837	0	0
Gilead Sciences, Inc.	Common	375558103	129,423,575	1,559,884	SH		SOLE		129,423,575	0	0
Global Medical REIT Inc.	Common	37954A204	1,593,312	174,897	SH		SOLE		1,593,312	0	0
GSK plc	Sponsored ADR	37733W204	1,489,094	41,852	SH		SOLE		1,489,094	0	0
Guardant Health, Inc.	Common	40131M109	11,067,993	472,184	SH		SOLE		11,067,993	0	0
Harpoon Therapeutics, Inc.	Common	41358P106	193,425	259,910	SH		SOLE		193,425	0	0
HCA Healthcare, Inc.	Common	40412C101	23,389,207	88,703	SH		SOLE		23,389,207	0	0
Healthcare Realty Trust Inc.	Common	42226K105	3,376,680	174,686	SH		SOLE		3,376,680	0	0
Healthpeak Properties, Inc.	Common	42250P103	3,304,112	150,392	SH		SOLE		3,304,112	0	0
Humana Inc.	Common	444859102	17,862,015	36,794	SH		SOLE		17,862,015	0	0
I-Mab	Sponsored ADS	44975P103	562,527	162,580	SH		SOLE		562,527	0	0
Icon plc	Shares	G4705A100	1,993,649	9,334	SH		SOLE		1,993,649	0	0
IDEXX Laboratories, Inc.	Common	45168D104	29,302,188	58,595	SH		SOLE		29,302,188	0	0
Illumina, Inc.	Common	452327109	80,945,771	348,079	SH		SOLE		80,945,771	0	0
Immunovant, Inc.	Common	45258J102	1,789,854	115,400	SH		SOLE		1,789,854	0	0
Intellia Therapeutics, Inc.	Common	45826J105	5,749,606	154,269	SH		SOLE		5,749,606	0	0
Intercept Pharmaceuticals, Inc.	Common	45845P108	699,260	52,067	SH		SOLE		699,260	0	0
Intra-Cellular Therapies, Inc.	Common	46116X101	9,333,890	172,371	SH		SOLE		9,333,890	0	0
Intuitive Surgical, Inc.	Common	46120E602	28,786,360	112,680	SH		SOLE		28,786,360	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	3,139,402	87,840	SH		SOLE		3,139,402	0	0
IQVIA Holdings Inc.	Common	46266C105	12,553,340	63,117	SH		SOLE		12,553,340	0	0
Ishares Biothechnology ETF	Common	464287556	3,173,332	24,569	SH		SOLE		3,173,332	0	0
iTeos Therapeutics, Inc.	Common	46565G104	622,453	45,735	SH		SOLE		622,453	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	21,624,501	147,779	SH		SOLE		21,624,501	0	0
Johnson & Johnson	Common	478160104	111,875,745	721,779	SH		SOLE		111,875,745	0	0
Karuna Therapeutics, Inc.	Common	48576A100	9,709,021	53,452	SH		SOLE		9,709,021	0	0
Koninklijke Philips N.V.	NY Reg Shares	500472303	2,015,931	109,860	SH		SOLE		2,015,931	0	0
Kura Oncology, Inc.	Common	50127T109	3,464,527	283,281	SH		SOLE		3,464,527	0	0
Laboratory Corporation of America Holdings	Common	50540R409	9,186,436	40,042	SH		SOLE		9,186,436	0	0
Lantheus Holdings, Inc.	Common	516544103	6,563,107	79,495	SH		SOLE		6,563,107	0	0
LivaNova plc	Common	G5509L101	2,783,890	63,880	SH		SOLE		2,783,890	0	0
LTC Properties, Inc.	Common	502175102	6,403,953	182,293	SH		SOLE		6,403,953	0	0
Madrigal Pharmaceuticals, Inc.	Common	558868105	3,023,647	12,481	SH		SOLE		3,023,647	0	0
Mallinckrodt plc	Shares	G5890A102	255,503	35,048	SH		SOLE		255,503	0	0
Marinus Pharmaceuticals, Inc.	Common	56854Q200	3,151,782	456,780	SH		SOLE		3,151,782	0	0
McKesson Corp.	Common	58155Q103	23,661,303	66,455	SH		SOLE		23,661,303	0	0
Medical Properties Trust, Inc.	Common	58463J304	3,384,527	411,743	SH		SOLE		3,384,527	0	0
Medpace Holdings, Inc.	Common	58506Q109	1,774,252	9,435	SH		SOLE		1,774,252	0	0
Medtronic plc	Shares	G5960L103	27,774,961	344,517	SH		SOLE		27,774,961	0	0
Merck & Co., Inc.	Common	58933Y105	58,740,260	552,122	SH		SOLE		58,740,260	0	0
Mereo BioPharma Group plc	ADS	589492107	1,096,460	1,551,082	SH		SOLE		1,096,460	0	0
Mersana Therapeutics, Inc.	Common	59045L106	667,394	162,383	SH		SOLE		667,394	0	0
Merus N.V.	Common	N5749R100	1,270,060	69,025	SH		SOLE		1,270,060	0	0
Mirati Therapeutics, Inc.	Common	60468T105	2,434,918	65,490	SH		SOLE		2,434,918	0	0
Moderna, Inc.	Common	60770K107	49,486,087	322,217	SH		SOLE		49,486,087	0	0
Molina Healthcare, Inc.	Common	60855R100	16,545,861	61,856	SH		SOLE		16,545,861	0	0
MorphoSys AG	Sponsored ADS	617760202	323,375	81,867	SH		SOLE		323,375	0	0
Natera, Inc.	Common	632307104	2,735,581	49,272	SH		SOLE		2,735,581	0	0
National Health Investors, Inc.	Common	63633D104	517,760	10,038	SH		SOLE		517,760	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	11,428,548	112,908	SH		SOLE		11,428,548	0	0
NexGel, Inc.	Common	65344E107	5,516	4,243	SH		SOLE		5,516	0	0
Nkarta, Inc.	Common	65487U108	102,907	28,988	SH		SOLE		102,907	0	0
Novartis AG	Sponsored ADR	66987V109	12,532,700	136,225	SH		SOLE		12,532,700	0	0
Novavax, Inc.	Common	670002401	442,134	63,800	SH		SOLE		442,134	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	17,715,942	111,323	SH		SOLE		17,715,942	0	0
Oculis Holding AG	Common	952KVL905	11,047,302	1,690,741	SH		SOLE		11,047,302	0	0
Omega Healthcare Investors, Inc.	Common	681936100	8,399,329	306,433	SH		SOLE		8,399,329	0	0
Option Care Health, Inc.	Common	68404L201	2,064,256	64,975	SH		SOLE		2,064,256	0	0
Perrigo Company plc	Shares	G97822103	1,837,405	51,224	SH		SOLE		1,837,405	0	0
Pfizer Inc.	Common	717081103	72,423,101	1,775,076	SH		SOLE		72,423,101	0	0
Physicians Realty Trust	Common	71943U104	13,043,669	873,655	SH		SOLE		13,043,669	0	0
Praxis Precision Medicines, Inc.	Common	74006W108	60,675	75,000	SH		SOLE		60,675	0	0
Precision BioSciences, Inc.	Common	74019P108	169,209	224,534	SH		SOLE		169,209	0	0
Prometheus Biosciences, Inc.	Common	74349U108	5,423,738	50,538	SH		SOLE		5,423,738	0	0
Pyxis Oncology, Inc.	Common	747324101	2,840,295	708,303	SH		SOLE		2,840,295	0	0
R1 RCM Inc.	Common	77634L105	5,352,765	356,851	SH		SOLE		5,352,765	0	0
Rallybio Corporation	Common	75120L100	9,861,553	1,727,067	SH		SOLE		9,861,553	0	0
Reata Pharmaceuticals, Inc. Class A	Class A	75615P103	1,622,922	17,850	SH		SOLE		1,622,922	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	117,542,359	143,053	SH		SOLE		117,542,359	0	0
Repare Therapeutics Inc.	Common	760273102	286,836	29,150	SH		SOLE		286,836	0	0
ResMed Inc.	Common	761152107	16,027,659	73,189	SH		SOLE		16,027,659	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	5,872,590	510,660	SH		SOLE		5,872,590	0	0
Sanofi	Sponsored ADR	80105N105	6,718,367	123,454	SH		SOLE		6,718,367	0	0
Sarepta Therapeutics, Inc.	Common	803607100	39,371,553	285,653	SH		SOLE		39,371,553	0	0
Scholar Rock Holding Corp.	Common	80706P103	870,664	108,833	SH		SOLE		870,664	0	0
Seagen Inc.	Common	81181C104	45,487,518	224,663	SH		SOLE		45,487,518	0	0
Smith & Nephew plc	Sponsored ADR	83175M205	5,071,526	181,710	SH		SOLE		5,071,526	0	0
SPDR S&P Biotech ETF	S&P Biotech ETF	78464A870	11,254,464	147,677	SH		SOLE		11,254,464	0	0
Spectrum Pharmaceuticals, Inc.	Common	84763A108	86,003	114,670	SH		SOLE		86,003	0	0
STERIS plc	Shares	G8473T100	5,943,452	31,072	SH		SOLE		5,943,452	0	0
Stryker Corp.	Common	863667101	20,433,372	71,578	SH		SOLE		20,433,372	0	0
Sutro Biopharma, Inc.	Common	869367102	454,395	98,354	SH		SOLE		454,395	0	0
Syndax Pharmaceuticals, Inc.	Common	87164F105	2,486,183	117,717	SH		SOLE		2,486,183	0	0
Tactile Systems Technology, Inc.	Common	87357P100	565,373	34,432	SH		SOLE		565,373	0	0
Takeda Pharmaceutical Company Ltd.	Sponsored ADS	874060205	1,731,603	105,073	SH		SOLE		1,731,603	0	0
Teva Pharmaceutical Industries Ltd.	Sponsored ADR	881624209	4,067,911	459,651	SH		SOLE		4,067,911	0	0
Thermo Fisher Scientific Inc.	Common	883556102	54,008,751	93,705	SH		SOLE		54,008,751	0	0
Theseus Pharmaceuticals, Inc.	Common	88369M101	666,000	75,000	SH		SOLE		666,000	0	0
Travere Therapeutics, Inc.	Common	89422G107	9,412,515	418,520	SH		SOLE		9,412,515	0	0
TScan Therapeutics, Inc.	Common	89854M101	420,000	200,000	SH		SOLE		420,000	0	0
Ultragenyx Pharmaceutical Inc.	Common	90400D108	2,689,307	67,065	SH		SOLE		2,689,307	0	0
uniQure N.V.	Shares	N90064101	13,140,262	652,446	SH		SOLE		13,140,262	0	0
United Therapeutics Corp.	Common	91307C102	13,706,352	61,200	SH		SOLE		13,706,352	0	0
Unitedhealth Group Inc.	Common	91324P102	110,667,818	234,173	SH		SOLE		110,667,818	0	0
Universal Health Realty Income Trust	Common	91359E105	541,622	11,258	SH		SOLE		541,622	0	0
Vaxcyte, Inc.	Common	92243G108	187,400	5,000	SH		SOLE		187,400	0	0
VectivBio Holding AG	Common	H9060V101	5,872,372	682,834	SH		SOLE		5,872,372	0	0
Ventas, Inc.	Common	92276F100	2,890,621	66,681	SH		SOLE		2,890,621	0	0
Veradigm, Inc.	Common	01988P108	5,592,969	428,580	SH		SOLE		5,592,969	0	0
Vertex Pharmaceuticals Inc.	Common	92532F100	104,081,169	330,343	SH		SOLE		104,081,169	0	0
VYNE Therapeutics, Inc.	Common	92941V308	23,162	7,520	SH		SOLE		23,162	0	0
Welltower Inc.	Common	95040Q104	2,973,988	41,484	SH		SOLE		2,973,988	0	0
West Pharmaceutical Services, Inc.	Common	955306105	5,209,523	15,036	SH		SOLE		5,209,523	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	2,996,124	83,714	SH		SOLE		2,996,124	0	0
Zai Lab Ltd.	ADR	98887Q104	1,152,126	34,640	SH		SOLE		1,152,126	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	8,702,395	67,356	SH		SOLE		8,702,395	0	0
Zoetis Inc.	Class A	98978V103	22,787,966	136,914	SH		SOLE		22,787,966	0	0