Tekla Capital Management 13F-HR Quarterly holdings report by institutional manager

The Securities and Exchange Commission has not necessarily reviewed the information in this filing and has not determined if it is accurate and complete.
The reader should not assume that the information is accurate and complete.

UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549
FORM 13F

FORM 13F INFORMATION TABLE

OMB APPROVAL

OMB Number:		3235-0006
Expires:	Oct 31, 2018
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COLUMN 1	COLUMN 2	COLUMN 3	COLUMN 4	COLUMN 5			COLUMN 6	COLUMN 7	COLUMN 8
			VALUE	SHRS OR	SH/	PUT/	INVESTMENT	OTHER	VOTING AUTHORITY
NAME OF ISSUER	TITLE OF CLASS	CUSIP	(x$1000)	PRN AMT	PRN	CALL	DISCRETION	MANAGER	SOLE	SHARED	NONE
89bio, Inc.	Common	282559103	2,006,767	105,898	SH		SOLE		2,006,767	0	0
Abbott Laboratories	Common	002824100	60,228,644	552,455	SH		SOLE		60,228,644	0	0
AbbVie Inc.	Common	00287Y109	73,512,595	545,629	SH		SOLE		73,512,595	0	0
Acadia Healthcare Company, Inc.	Common	00404A109	8,036,632	100,912	SH		SOLE		8,036,632	0	0
Adaptive Biotechnologies Corp.	Common	00650F109	2,833,506	422,281	SH		SOLE		2,833,506	0	0
Adicet Bio, Inc.	Common	007002108	97,999	40,329	SH		SOLE		97,999	0	0
Affimed N.V.	Common	N01045108	350,568	586,038	SH		SOLE		350,568	0	0
Agilent Technologies, Inc.	Common	00846U101	5,193,718	43,191	SH		SOLE		5,193,718	0	0
Akero Therapeutics, Inc.	Common	00973Y108	2,871,295	61,497	SH		SOLE		2,871,295	0	0
Alkermes plc	Shares	G01767105	9,690,887	309,613	SH		SOLE		9,690,887	0	0
Alnylam Pharmaceuticals, Inc.	Common	02043Q107	27,202,067	143,214	SH		SOLE		27,202,067	0	0
Altimmune, Inc.	Common	02155H200	264,750	75,000	SH		SOLE		264,750	0	0
ALX Oncology Holdings Inc.	Common	00166B105	497,245	66,211	SH		SOLE		497,245	0	0
Amerisourcebergen Corp.	Common	03073E105	3,928,843	20,417	SH		SOLE		3,928,843	0	0
Amgen Inc.	Common	031162100	136,883,989	616,539	SH		SOLE		136,883,989	0	0
Amylyx Pharmaceuticals, Inc.	Common	03237H101	2,243,431	104,007	SH		SOLE		2,243,431	0	0
Apellis Pharmaceuticals, Inc.	Common	03753U106	15,782,893	173,248	SH		SOLE		15,782,893	0	0
ARCA biopharma, Inc.	Common	00211Y506	65,896	32,461	SH		SOLE		65,896	0	0
Arcus Biosciences, Inc.	Common	03969F109	666,960	32,839	SH		SOLE		666,960	0	0
Arcutis Biotherapeutics, Inc.	Common	03969K108	1,418,769	148,874	SH		SOLE		1,418,769	0	0
Ardelyx, Inc.	Common	039697107	1,828,593	539,408	SH		SOLE		1,828,593	0	0
argenx SE	Sponsored ADR	04016X101	25,547,971	65,553	SH		SOLE		25,547,971	0	0
Ascendis Pharma A/S	Sponsored ADR	04351P101	12,387,097	138,791	SH		SOLE		12,387,097	0	0
Assertio Holdings, Inc.	Common	04546C205	2,225,317	410,575	SH		SOLE		2,225,317	0	0
AstraZeneca PLC	Sponsored ADR	046353108	69,900,701	976,676	SH		SOLE		69,900,701	0	0
Avantor, Inc.	Common	05352A100	9,437,884	459,488	SH		SOLE		9,437,884	0	0
Baxter International, Inc.	Common	071813109	14,778,297	324,370	SH		SOLE		14,778,297	0	0
Beam Therapeutics Inc.	Common	07373V105	505,037	15,817	SH		SOLE		505,037	0	0
BeiGene, Ltd.	Sponsored ADR	07725L102	3,735,742	20,952	SH		SOLE		3,735,742	0	0
Bellicum Pharmaceuticals, Inc.	Common	079481404	2,220	6,000	SH		SOLE		2,220	0	0
Bicycle Therapeutics PLC	Sponsored ADS	088786108	1,131,506	44,338	SH		SOLE		1,131,506	0	0
BioCryst Pharmaceuticals, Inc.	Common	09058V103	3,551,877	504,528	SH		SOLE		3,551,877	0	0
Biogen Inc.	Common	09062X103	70,626,564	247,943	SH		SOLE		70,626,564	0	0
BioMarin Pharmaceutical Inc.	Common	09061G101	18,271,191	210,789	SH		SOLE		18,271,191	0	0
BioNTech SE	Sponsored ADS	09075V102	11,209,394	103,858	SH		SOLE		11,209,394	0	0
Black Diamond Therapeutics, Inc.	Common	09203E105	666,550	131,990	SH		SOLE		666,550	0	0
Boston Scientific Corp.	Common	101137107	35,579,861	657,790	SH		SOLE		35,579,861	0	0
Bridgebio Pharma, Inc.	Common	10806X102	2,595,841	150,921	SH		SOLE		2,595,841	0	0
Bristol-Myers Squibb Company	Common	110122108	29,320,947	458,498	SH		SOLE		29,320,947	0	0
Caribou Biosciences, Inc.	Common	142038108	2,410,375	567,147	SH		SOLE		2,410,375	0	0
Cerevel Therapeutics Holdings, Inc.	Common	15678U128	5,610,395	176,483	SH		SOLE		5,610,395	0	0
Charles River Laboratories International, Inc.	Common	159864107	23,376,226	111,183	SH		SOLE		23,376,226	0	0
Chinook Therapeutics, Inc.	Common	16961L106	5,796,156	150,863	SH		SOLE		5,796,156	0	0
Codexis Inc	Common	192005106	193,550	69,125	SH		SOLE		193,550	0	0
Community Health Systems, Inc.	Common	203668108	388,674	88,335	SH		SOLE		388,674	0	0
Community Healthcare Trust Inc.	Common	20369C106	491,998	14,900	SH		SOLE		491,998	0	0
Corbus Pharmaceuticals Holdings, Inc.	Common	21833P301	40,321	5,143	SH		SOLE		40,321	0	0
Crinetics Pharmaceuticals, Inc.	Common	22663K107	1,415,093	78,529	SH		SOLE		1,415,093	0	0
CRISPR Therapeutics AG	Namen AKT	H17182108	1,267,136	22,571	SH		SOLE		1,267,136	0	0
CVS Health Corp.	Common	126650100	6,472,020	93,621	SH		SOLE		6,472,020	0	0
Cytokinetics, Inc.	Common	23282W605	7,144,596	219,025	SH		SOLE		7,144,596	0	0
Danaher Corp.	Common	235851102	34,275,120	142,813	SH		SOLE		34,275,120	0	0
Denali Therapeutics, Inc.	Common	24823R105	9,585,704	324,829	SH		SOLE		9,585,704	0	0
Dexcom, Inc.	Common	252131107	29,396,277	228,747	SH		SOLE		29,396,277	0	0
Diversified Healthcare Trust	Common	25525P107	804,870	357,720	SH		SOLE		804,870	0	0
Edgewise Therapeutics, Inc.	Common	28036F105	1,165,740	150,418	SH		SOLE		1,165,740	0	0
Edwards Lifesciences Corp.	Common	28176E108	17,884,685	189,597	SH		SOLE		17,884,685	0	0
Elevance Health, Inc.	Common	036752103	50,680,160	114,070	SH		SOLE		50,680,160	0	0
Eli Lilly and Company	Common	532457108	100,057,821	213,352	SH		SOLE		100,057,821	0	0
Exelixis, Inc.	Common	30161Q104	13,886,071	726,639	SH		SOLE		13,886,071	0	0
Fulcrum Therapeutics, Inc.	Common	359616109	847,730	256,888	SH		SOLE		847,730	0	0
Fusion Pharmaceuticals Inc.	Common	36118A100	203,084	43,394	SH		SOLE		203,084	0	0
G1 Therapeutics, Inc.	Common	3621LQ109	1,055,434	423,869	SH		SOLE		1,055,434	0	0
Galera Therapeutics, Inc.	Common	36338D108	2,802,927	898,374	SH		SOLE		2,802,927	0	0
Gilead Sciences, Inc.	Common	375558103	118,216,440	1,533,884	SH		SOLE		118,216,440	0	0
Global Medical REIT Inc.	Common	37954A204	1,596,810	174,897	SH		SOLE		1,596,810	0	0
GSK plc	Sponsored ADR	37733W204	1,491,605	41,852	SH		SOLE		1,491,605	0	0
Guardant Health, Inc.	Common	40131M109	12,389,807	346,084	SH		SOLE		12,389,807	0	0
Harpoon Therapeutics, Inc.	Common	41358P106	184,536	259,910	SH		SOLE		184,536	0	0
HCA Healthcare, Inc.	Common	40412C101	25,007,662	82,403	SH		SOLE		25,007,662	0	0
Healthcare Realty Trust Inc.	Common	42226K105	3,294,578	174,686	SH		SOLE		3,294,578	0	0
Healthpeak Properties, Inc.	Common	42250P103	3,022,879	150,392	SH		SOLE		3,022,879	0	0
HilleVax, Inc.	Common	43157M102	464,130	27,000	SH		SOLE		464,130	0	0
Horizon Therapeutics plc	Common	G46188101	7,448,911	72,425	SH		SOLE		7,448,911	0	0
Humana Inc.	Common	444859102	16,451,701	36,794	SH		SOLE		16,451,701	0	0
I-Mab	Sponsored ADS	44975P103	486,114	162,580	SH		SOLE		486,114	0	0
Icon plc	Shares	G4705A100	2,335,367	9,334	SH		SOLE		2,335,367	0	0
IDEXX Laboratories, Inc.	Common	45168D104	29,428,167	58,595	SH		SOLE		29,428,167	0	0
Illumina, Inc.	Common	452327109	63,180,193	336,979	SH		SOLE		63,180,193	0	0
Immunovant, Inc.	Common	45258J102	6,377,714	336,200	SH		SOLE		6,377,714	0	0
Inspire Medical Systems, Inc.	Common	457730109	7,147,924	22,018	SH		SOLE		7,147,924	0	0
Insulet Corp.	Common	45784P101	12,642,844	43,847	SH		SOLE		12,642,844	0	0
Intellia Therapeutics, Inc.	Common	45826J105	6,291,090	154,269	SH		SOLE		6,291,090	0	0
Intercept Pharmaceuticals, Inc.	Common	45845P108	575,861	52,067	SH		SOLE		575,861	0	0
Intra-Cellular Therapies, Inc.	Common	46116X101	8,322,464	131,435	SH		SOLE		8,322,464	0	0
Intuitive Surgical, Inc.	Common	46120E602	28,716,121	83,980	SH		SOLE		28,716,121	0	0
Ionis Pharmaceuticals, Inc.	Common	462222100	3,604,075	87,840	SH		SOLE		3,604,075	0	0
IQVIA Holdings Inc.	Common	46266C105	24,528,925	109,129	SH		SOLE		24,528,925	0	0
Ishares Biothechnology ETF	Common	464287556	3,119,280	24,569	SH		SOLE		3,119,280	0	0
iTeos Therapeutics, Inc.	Common	46565G104	605,531	45,735	SH		SOLE		605,531	0	0
Jazz Pharmaceuticals plc	Shares	G50871105	18,320,163	147,779	SH		SOLE		18,320,163	0	0
Johnson & Johnson	Common	478160104	119,468,860	721,779	SH		SOLE		119,468,860	0	0
Karuna Therapeutics, Inc.	Common	48576A100	12,702,422	58,577	SH		SOLE		12,702,422	0	0
Koninklijke Philips N.V.	NY Reg Shares	500472303	2,489,253	114,765	SH		SOLE		2,489,253	0	0
LivaNova plc	Common	G5509L101	5,579,126	108,480	SH		SOLE		5,579,126	0	0
LTC Properties, Inc.	Common	502175102	6,019,315	182,293	SH		SOLE		6,019,315	0	0
Madrigal Pharmaceuticals, Inc.	Common	558868105	7,954,254	34,434	SH		SOLE		7,954,254	0	0
Mallinckrodt plc	Shares	G5890A102	41,357	35,048	SH		SOLE		41,357	0	0
Marinus Pharmaceuticals, Inc.	Common	56854Q200	4,464,557	411,101	SH		SOLE		4,464,557	0	0
McKesson Corp.	Common	58155Q103	26,473,991	61,955	SH		SOLE		26,473,991	0	0
Medical Properties Trust, Inc.	Common	58463J304	3,812,740	411,743	SH		SOLE		3,812,740	0	0
Medpace Holdings, Inc.	Common	58506Q109	6,464,896	26,918	SH		SOLE		6,464,896	0	0
Medtronic plc	Shares	G5960L103	30,343,138	344,417	SH		SOLE		30,343,138	0	0
Merck & Co., Inc.	Common	58933Y105	84,021,690	728,154	SH		SOLE		84,021,690	0	0
Mereo BioPharma Group plc	ADS	589492107	2,047,428	1,551,082	SH		SOLE		2,047,428	0	0
Mirati Therapeutics, Inc.	Common	60468T105	2,366,154	65,490	SH		SOLE		2,366,154	0	0
Moderna, Inc.	Common	60770K107	41,758,943	343,695	SH		SOLE		41,758,943	0	0
Molina Healthcare, Inc.	Common	60855R100	18,633,501	61,856	SH		SOLE		18,633,501	0	0
MorphoSys AG	Sponsored ADS	617760202	1,323,617	177,191	SH		SOLE		1,323,617	0	0
Natera, Inc.	Common	632307104	1,198,788	24,636	SH		SOLE		1,198,788	0	0
National Health Investors, Inc.	Common	63633D104	526,192	10,038	SH		SOLE		526,192	0	0
Neurocrine Biosciences, Inc.	Common	64125C109	10,647,224	112,908	SH		SOLE		10,647,224	0	0
NexGel, Inc.	Common	65344E107	10,650	4,243	SH		SOLE		10,650	0	0
Nkarta, Inc.	Common	65487U108	63,484	28,988	SH		SOLE		63,484	0	0
Novartis AG	Sponsored ADR	66987V109	13,746,465	136,225	SH		SOLE		13,746,465	0	0
Novavax, Inc.	Common	670002401	474,034	63,800	SH		SOLE		474,034	0	0
Novo Nordisk A/S	Sponsored ADR	670100205	19,869,002	122,777	SH		SOLE		19,869,002	0	0
Oculis Holding AG	Common	952KVL905	18,823,020	1,690,741	SH		SOLE		18,823,020	0	0
Omega Healthcare Investors, Inc.	Common	681936100	9,404,429	306,433	SH		SOLE		9,404,429	0	0
Perrigo Company plc	Shares	G97822103	1,739,055	51,224	SH		SOLE		1,739,055	0	0
Pfizer Inc.	Common	717081103	59,585,780	1,624,476	SH		SOLE		59,585,780	0	0
Physicians Realty Trust	Common	71943U104	12,222,433	873,655	SH		SOLE		12,222,433	0	0
Praxis Precision Medicines, Inc.	Common	74006W108	86,250	75,000	SH		SOLE		86,250	0	0
Precision BioSciences, Inc.	Common	74019P108	118,105	224,534	SH		SOLE		118,105	0	0
Pyxis Oncology, Inc.	Common	747324101	1,813,256	708,303	SH		SOLE		1,813,256	0	0
R1 RCM Inc.	Common	77634L105	6,583,901	356,851	SH		SOLE		6,583,901	0	0
Rallybio Corporation	Common	75120L100	9,775,199	1,727,067	SH		SOLE		9,775,199	0	0
Reata Pharmaceuticals, Inc. Class A	Class A	75615P103	3,492,130	34,250	SH		SOLE		3,492,130	0	0
Regeneron Pharmaceuticals, Inc.	Common	75886F107	115,985,290	161,418	SH		SOLE		115,985,290	0	0
Repare Therapeutics Inc.	Common	760273102	308,407	29,150	SH		SOLE		308,407	0	0
ResMed Inc.	Common	761152107	7,582,824	34,704	SH		SOLE		7,582,824	0	0
Sabra Health Care REIT, Inc.	Common	78573L106	6,010,468	510,660	SH		SOLE		6,010,468	0	0
Sanofi	Sponsored ADR	80105N105	6,654,171	123,454	SH		SOLE		6,654,171	0	0
Sarepta Therapeutics, Inc.	Common	803607100	20,549,125	179,437	SH		SOLE		20,549,125	0	0
Scholar Rock Holding Corp.	Common	80706P103	820,601	108,833	SH		SOLE		820,601	0	0
Seagen Inc.	Common	81181C104	21,619,224	112,331	SH		SOLE		21,619,224	0	0
Smith & Nephew plc	Sponsored ADR	83175M205	5,860,148	181,710	SH		SOLE		5,860,148	0	0
SPDR S&P Biotech ETF	S&P Biotech ETF	78464A870	12,286,726	147,677	SH		SOLE		12,286,726	0	0
Spectrum Pharmaceuticals, Inc.	Common	84763A108	110,083	114,670	SH		SOLE		110,083	0	0
STERIS plc	Shares	G8473T100	6,990,579	31,072	SH		SOLE		6,990,579	0	0
Stryker Corp.	Common	863667101	24,751,342	81,128	SH		SOLE		24,751,342	0	0
Sutro Biopharma, Inc.	Common	869367102	457,346	98,354	SH		SOLE		457,346	0	0
Tactile Systems Technology, Inc.	Common	87357P100	1,457,707	58,472	SH		SOLE		1,457,707	0	0
Takeda Pharmaceutical Company Ltd.	Sponsored ADS	874060205	1,650,697	105,073	SH		SOLE		1,650,697	0	0
Tenet Healthcare Corp.	Common	88033G407	12,131,317	149,070	SH		SOLE		12,131,317	0	0
Teva Pharmaceutical Industries Ltd.	Sponsored ADR	881624209	3,461,172	459,651	SH		SOLE		3,461,172	0	0
The Cigna Group	Common	125523100	27,032,723	96,339	SH		SOLE		27,032,723	0	0
Thermo Fisher Scientific Inc.	Common	883556102	51,646,467	98,987	SH		SOLE		51,646,467	0	0
Theseus Pharmaceuticals, Inc.	Common	88369M101	699,750	75,000	SH		SOLE		699,750	0	0
TScan Therapeutics, Inc.	Common	89854M101	500,000	200,000	SH		SOLE		500,000	0	0
uniQure N.V.	Shares	N90064101	4,082,969	356,280	SH		SOLE		4,082,969	0	0
United Therapeutics Corp.	Common	91307C102	9,153,399	41,465	SH		SOLE		9,153,399	0	0
Unitedhealth Group Inc.	Common	91324P102	99,473,735	206,961	SH		SOLE		99,473,735	0	0
Universal Health Realty Income Trust	Common	91359E105	535,656	11,258	SH		SOLE		535,656	0	0
Vaxcyte, Inc.	Common	92243G108	9,699,946	194,232	SH		SOLE		9,699,946	0	0
Ventas, Inc.	Common	92276F100	3,152,011	66,681	SH		SOLE		3,152,011	0	0
Veradigm, Inc.	Common	01988P108	5,400,108	428,580	SH		SOLE		5,400,108	0	0
Vertex Pharmaceuticals Inc.	Common	92532F100	111,922,512	318,043	SH		SOLE		111,922,512	0	0
VYNE Therapeutics, Inc.	Common	92941V308	30,531	7,520	SH		SOLE		30,531	0	0
Welltower Inc.	Common	95040Q104	3,355,641	41,484	SH		SOLE		3,355,641	0	0
West Pharmaceutical Services, Inc.	Common	955306105	5,750,819	15,036	SH		SOLE		5,750,819	0	0
Xencor, Inc.	Common	98401F105	1,415,175	56,675	SH		SOLE		1,415,175	0	0
Xenon Pharmaceuticals Inc.	Common	98420N105	2,598,981	67,506	SH		SOLE		2,598,981	0	0
Zentalis Pharmaceuticals, Inc.	Common	98943L107	1,132,801	40,156	SH		SOLE		1,132,801	0	0
Zimmer Biomet Holdings, Inc.	Common	98956P102	9,807,034	67,356	SH		SOLE		9,807,034	0	0
Zoetis Inc.	Class A	98978V103	23,577,960	136,914	SH		SOLE		23,577,960	0	0