Aveo Pharmaceuticals (AVEO) S-3 Shelf registration

Exhibit 12.1

STATEMENT REGARDING COMPUTATION OF RATIO/DEFICIENCY OF EARNINGS TO FIXED CHARGES

(dollars in thousands)

	Three Months  Ended March 31, 2011		Fiscal Year Ended December 31,												2006
			2010			2009			2008			2007
Fixed charges:
Interest expense on indebtedness	$	744	$	2,537		$	2,125		$	1,610		$	1,886		$	1,359
Noncash interest expense and other		268		1,434			686			725			552			232
Interest expense on portion of rent expense representative of interest		96		352			351			327			317			317
Total fixed charges	$	1,108	$	4,323		$	3,162		$	2,662		$	2,755		$	1,908
Earnings (loss):
Net income (loss) before benefit for income taxes	$	85,366	$	(58,789	)	$	(44,193	)	$	(32,473	)	$	(24,982	)	$	(24,905	)
Fixed charges per above		1,108		4,323			3,162			2,662			2,755			1,908
Total earnings (loss)	$	86,474	$	(54,466	)	$	(41,031	)	$	(29,811	)	$	(22,227	)	$	(22,997	)
Ratio of earnings to fixed charges		78.0		—			—			—			—			—
Deficiency of earnings available to cover fixed charges		—	$	(58,789	)	$	(44,193	)	$	(32,473	)	$	(24,982	)	$	(24,905	)