Protea Biosciences 10-Q 2016 Q2 Quarterly report

Exhibit 32.1

Certification Pursuant to 18 U.S.C. Section 1350,

as adopted pursuant to Section 906 of the Sarbanes-Oxley Act of 2002

In connection with the Quarterly Report of Protea Biosciences Group, Inc. (the “Company”) on Form 10-Q for the period ending June 30, 2016, as filed with the U.S. Securities and Exchange Commission on the date hereof (the “Report”), I, Stephen Turner, certify, pursuant to 18 U.S.C. ss. 1350, as adopted pursuant to ss. 906 of the Sarbanes-Oxley Act of 2002, that to my knowledge:

(1) The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

/s/ Stephen Turner

Stephen Turner

Chief Executive Officer, President and Director

(Principal Executive Officer, Interim Principal Financial and Accounting Officer)

August 15, 2016