| Cover | Jun. 23, 2023 |
| Statement [Line Items] | |
| Document Type | 8-K |
| Amendment Flag | false |
| Document Period End Date | Jun. 23, 2023 |
| Entity File Number | 001-39717 |
| Entity Registrant Name | LIXTE BIOTECHNOLOGY HOLDINGS, INC. |
| Entity Central Index Key | 0001335105 |
| Entity Tax Identification Number | 20-2903526 |
| Entity Incorporation, State or Country Code | DE |
| Entity Address, Address Line One | 680 East Colorado Boulevard |
| Entity Address, Address Line Two | Suite 180 |
| Entity Address, City or Town | Pasadena |
| Entity Address, State or Province | CA |
| Entity Address, Postal Zip Code | 91101 |
| City Area Code | (631) |
| Local Phone Number | 830-7092 |
| Written Communications | false |
| Soliciting Material | false |
| Pre-commencement Tender Offer | false |
| Pre-commencement Issuer Tender Offer | false |
| Common Stock, par value $0.0001 per share | |
| Statement [Line Items] | |
| Title of 12(b) Security | Common Stock, par value $0.0001 per share |
| Trading Symbol | LIXT |
| Security Exchange Name | NASDAQ |
| Warrants to Purchase Common Stock, par value $0.0001 per share | |
| Statement [Line Items] | |
| Title of 12(b) Security | Warrants to Purchase Common Stock, par value $0.0001 per share |
| Trading Symbol | LIXTW |
| Security Exchange Name | NASDAQ |
