Equity Incentive Plans | (10) Equity Incentive Plans Stock-Based Awards (a) Stock Option Plans In June 2021, in connection with the IPO, our 2021 Equity Incentive Plan (2021 Plan) became effective, which was adopted by our Board of Directors in February 2021 and our stockholders approved the 2021 Plan in March 2021. The 2021 Plan is administered by our compensation committee. Upon the effectiveness of the 2021 Plan, no new grants will be awarded under our 2015 Stock-Based Incentive Compensation Plan. As of June 30, 2022, the total number of shares of common stock reserved for future awards under the 2021 Plan is 1,313,137. Activity under the stock option plans was as follows: Number of options Weighted average exercise price Weighted average remaining contracted term in years Aggregate intrinsic value Outstanding at December 31, 2021 689,995 $ 3.58 $ 683,531 Granted 270,170 6.71 Expired (3,334 ) 27.00 Forfeited (834 ) 6.12 Outstanding at March 31, 2022 955,997 $ 4.38 6.47 $ 125,279 Granted 51,000 1.50 Exercised (9,445 ) 1.71 Expired (278 ) 27.00 Forfeited (46,668 ) 3.27 Outstanding at June 30, 2022 950,606 $ 4.30 6.55 $ 181,745 Vested and exercisable at June 30, 2022 476,941 $ 3.71 5.08 $ 57,557 Options granted under our 2021 Plan for the six months ended June 30, 2022 to employees and nonemployees were 253,170 and 68,000, respectively, and the weighted average exercise prices were $6.96 and $1.88, respectively. Included in awards granted to employees are 140,000 of performance based options that vest on achieving certain clinical related milestones. The weighted-average weighted-average Employee Nonemployee Expected term (in years) 6.47 5.63 Risk‑free interest rate 1.74 % 2.67 % Dividend yield — % — % Expected volatility 107.23 % 109.67 % The intrinsic value of options exercised during the six months ended June 30, 2022 was $3,306. The intrinsic value represents the dollar value of the exercised stock options whereby the fair market value of the underlying common stock exceeded the exercise price of the stock option as of the exercise date (b) Inducement Grant On February 28, 2022, the Company awarded, outside the 2021 Plan, our Chief Financial Officer a stock option grant for the right to purchase 100,000 shares of common stock at an exercise price of $2.97 per share (inducement grant), which was approved by the Compensation Committee. The inducement grant will vest in equal installments over four years provided the employee remains employed by the Company on the vesting date. The fair value of the inducement grant was $2.46 and was estimated using the following assumptions: Inducement Expected term (in years) 6.25 Risk‑free interest rate 1.76 % Dividend yield — % Expected volatility 106.76 % As of June 30, 2022, 100,000 shares are outstanding, and none are exercisable. (c) Share-Based Compensation Expense The following table shows the share-based compensation expense related to vested stock option grants to employees and nonemployees by financial statement line item on the accompanying statement of comprehensive loss: Three Months Ended June 30, Six Months Ended June 30, 2022 2021 2022 2021 Research and development $ 33,436 29,205 62,575 64,702 Sales and marketing 1,216 936 2,342 1,861 General and administrative 27,515 27,905 41,609 63,973 Total share-based compensation expense $ 62,167 58,046 106,526 130,536 As June 30, 2022, the remaining share-based compensation expense that is expected to be recognized in future periods for employees and nonemployees is $1,123,502, which includes $463,311 of compensation expense to be recognized upon achieving certain performance conditions. For service based awards, the $660,191 of unrecognized expense is expected to be recognized over a weighted average period of 3.0 years. (d) Employee Stock Purchase Plan In June 2021, in connection with the IPO, our Employee Stock Purchase Plan (ESPP) became effective which was adopted by our Board of Directors in February 2021 and our stockholders approved the 2021 ESPP Plan in March 2021. The ESPP is administered by our compensation committee. As of June 30, 2022, the total number of shares of common stock reserved for future awards under the ESPP Plan is 284,707, and no shares of our common stock have been purchased under the ESPP. |