EXHIBIT 1
AGREEMENT
Pursuant to Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, the undersigned hereby agree that only one statement containing the information required by Schedule 13D need to be filed with respect to the ownership by each of the undersigned of shares of Common Stock of Tobira Therapeutics, Inc.
| Dated November 3, 2016 | Frazier Healthcare V, L.P. | |||||
| By FHM V, L.P., its General Partner | ||||||
| By FHM V, L.L.C., its General Partner | ||||||
| By: | /s/ Steve R. Bailey | |||||
| Steve R. Bailey, Chief Financial Officer | ||||||
| Dated November 3, 2016 | FHM V, L.P. | |||||
| By: FHM V, L.L.C., its General Partner | ||||||
| By: | /s/ Steve R. Bailey | |||||
| Steve R. Bailey, Chief Financial Officer | ||||||
| Dated November 3, 2016 | FHM V, L.L.C. | |||||
| By: | /s/ Steve R. Bailey | |||||
| Steve R. Bailey, Chief Financial Officer | ||||||
| Dated November 3, 2016 | * | |||||
| Alan Frazier | ||||||
| Dated November 3, 2016 | * | |||||
| Nader Naini | ||||||
| Dated November 3, 2016 | * | |||||
| Patrick Heron | ||||||
| Dated November 3, 2016 | * | |||||
| James Topper | ||||||
| Dated November 3, 2016 | * | |||||
| Nathan Every | ||||||
| *By: | /s/ Steve R. Bailey | |||||
| Steve R. Bailey, as Attorney-in-Fact | ||||||
This Schedule 13D was executed by Steve R. Bailey on behalf of the individuals listed above pursuant to a Power of Attorney a copy of which is attached as Exhibit 2.
