Stock Incentive Plan | 9. STOCK INCENTIVE PLAN The Company has three equity incentive plans. One was adopted in 2004 (2004 Plan) and provided for the granting of stock options and restricted stock awards and generally prescribed a contractual term of seven years. The 2004 Plan terminated in August 2010. However, grants made under the 2004 Plan are still governed by that plan. As of September 30, 2018, options to purchase 23,954 shares of common stock at a weighted average exercise price of $3.24 per share remained outstanding under the 2004 Plan. The Company approved the 2010 Employee, Director and Consultant Equity Incentive Plan (2010 Plan) in September 2010 to replace the 2004 Plan. The 2010 Plan provided for the granting of stock options and restricted stock awards. The 2010 Plan terminated in May 2014 upon the Company’s initial public offering (Initial Public Offering). However, grants made under the 2010 Plan are still governed by that plan. As of September 30, 2018, options to purchase 413,130 shares of common stock at a weighted average exercise price of $1.58 per share remained outstanding under the 2010 Plan. The Company approved the 2013 Equity Incentive Plan (2013 Plan) in October 2013. The 2013 Plan became effective immediately on adoption although no awards were to be made under it until the effective date of the registration statement for the Initial Public Offering. The 2013 Plan provides for the granting of stock options, restricted stock, stock appreciation rights, stock units, and performance cash awards to certain employees, members of the board of directors and consultants of the Company. The 2013 Plan was amended in June 2018. The amended 2013 Plan provides that commencing in 2019, on January 1 of each year the aggregate number of common shares that may be issued under the 2013 Plan shall automatically increase by such a number of shares equal to the lower of (a) 6% of the total number of shares of common stock outstanding on the last calendar day of the prior fiscal year and (b) a number of shares of common stock determined by the Company’s board of directors. As of September 30, 2018, options to purchase 3,075,079 shares of common stock at a weighted average exercise price of $6.73 per share and 212,297 shares of common stock underlying restricted stock units (RSU’s) remained outstanding under the 2013 Plan. As of September 30, 2018, there were 418,406 shares of common stock available for grant under the 2013 Plan. Terms of stock award agreements, including vesting requirements, are determined by the Company’s board of directors or its compensation committee, subject to the provisions of the respective plan they were granted. Awards granted by the Company typically vest over a four year period. Certain of the awards are subject to acceleration of vesting in the event of certain change of control transactions. The awards may be granted for a term of up to ten years from the date of grant. The exercise price for options granted under the 2013 Plan must be at a price no less than 100% of the fair market value of a common share on the date of grant. The Company recognizes stock-based compensation expense over the requisite service period. The Company’s share-based awards are accounted for as equity instruments. The amounts included in the consolidated statements of operations relating to stock-based compensation are as follows: Three Months ended September 30, Nine Months ended September 30, 2018 2017 2018 2017 Research and development expenses $ 396,940 $ 224,341 $ 1,135,342 $ 691,747 General and administrative expenses 876,780 434,998 1,991,577 1,430,921 Total stock-based compensation expense $ 1,273,720 $ 659,339 $ 3,126,919 $ 2,122,668 Stock Options The table below summarizes activity relating to stock options under the incentive plans for the nine months ended September 30, 2018: Number of Weighted Weighted Aggregate (a) Outstanding at December 31, 2017 2,246,857 $ 4.87 Granted 1,265,306 8.27 Outstanding at September 30, 2018 3,512,163 $ 6.10 7.94 $ 27,056,003 Exercisable at September 30, 2018 1,725,007 $ 4.99 6.82 $ 15,195,549 (a) The aggregate intrinsic value in this table was calculated on the positive difference, if any, between the closing price per share of the Company’s common stock on September 30, 2018 of $13.80 and the per share exercise price of the underlying options. As of September 30, 2018, unamortized stock-based compensation for all stock options was $8,377,364 and will be recognized over a weighted average period of 2.85 years. Restricted Stock Units Terms of RSUs agreements, including vesting requirements, are determined by the board of directors or its compensation committee, subject to the provisions of the 2013 Plan. RSUs granted by the Company typically vest over a four year period. In the event that the employees’ employment with the Company terminates any unvested shares are forfeited and revert to the Company. Restricted stock units are not included in issued and outstanding common stock until the shares are vested and released. The table below summarizes activity relating to RSUs for the nine months ended September 30, 2018: Number Outstanding at December 31, 2017 157,128 Granted 96,144 Vested/released (40,975 ) Outstanding at September 30, 2018 212,297 The weighted-average fair value of RSUs granted was $8.60 per share for the nine months ended September 30, 2018. As of September 30, 2018, the outstanding restricted stock units had unamortized stock-based compensation of $1.2 million with a weighted-average remaining recognition period of 2.97 years and an aggregate intrinsic value of $3.1 million. Employee Stock Purchase Plan In March 2016, the Company’s board of directors approved the 2016 Employee Stock Purchase Plan (2016 ESPP), which became effective in June 2016 following the approval of the Company’s stockholders. The 2016 ESPP authorizes the issuance of up to a total of 414,639 shares of the Company’s common stock to participating employees. The number of shares reserved for issuance under the 2016 ESPP automatically increases on the first business day of each fiscal year, commencing in 2017, by a number equal to the lesser of (i) 1% of the shares of common stock outstanding on the last business day of the prior fiscal year; or (ii) the number of shares determined by the Company’s Board of Directors. Unless otherwise determined by the administrator of the 2016 ESPP, two offering periods of six months’ duration will begin each year on January 1 and July 1. Participating employees purchase stock under the 2016 ESPP at a price equal to the lower of 85% of the closing price on the applicable offering commencement date or 85% of the closing price on the applicable offering termination date. The fair value of the purchase rights granted under this plan was estimated on the date of grant using the Black-Scholes option-pricing model using assumptions, which were derived in a manner similar to those discussed above relative to stock options. At September 30, 2018, the Company had 368,772 shares available for issuance under the 2016 ESPP. A summary of the weighted-average grant-date fair value, shares issued and total stock-based compensation expense recognized related to the 2016 ESPP as of September 30, 2018 and 2017 are as follows: 2018 2017 Weighted-average grant-date fair value per share $ 2.97 $ 1.77 Total shares issued 34,345 11,522 Total stock-based compensation expense $ 56,514 $ 44,720 |