Document and Entity Information
Document and Entity Information - USD ($) $ in Billions | 12 Months Ended | ||
Dec. 31, 2017 | Feb. 15, 2018 | Jun. 30, 2017 | |
Document And Entity Information [Abstract] | |||
Document Type | 10-K | ||
Amendment Flag | false | ||
Document Period End Date | Dec. 31, 2017 | ||
Document Fiscal Year Focus | 2,017 | ||
Document Fiscal Period Focus | FY | ||
Trading Symbol | XON | ||
Entity Registrant Name | INTREXON CORP | ||
Entity Central Index Key | 1,356,090 | ||
Current Fiscal Year End Date | --12-31 | ||
Entity Well-known Seasoned Issuer | Yes | ||
Entity Current Reporting Status | Yes | ||
Entity Voluntary Filers | No | ||
Entity Filer Category | Large Accelerated Filer | ||
Entity Common Stock, Shares Outstanding | 129,066,114 | ||
Entity Public Float | $ 1.4 |
Consolidated Balance Sheets
Consolidated Balance Sheets - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 |
Current assets | ||
Cash and cash equivalents | $ 68,111 | $ 62,607 |
Restricted cash | 6,987 | 6,987 |
Short-term investments | 6,273 | 174,602 |
Equity securities | 5,285 | 0 |
Receivables | ||
Trade, net | 19,775 | 21,637 |
Related parties, net | 17,913 | 16,793 |
Notes, net | 0 | 1,500 |
Other | 2,153 | 2,555 |
Inventory | 20,493 | 21,139 |
Prepaid expenses and other | 7,057 | 7,361 |
Total current assets | 154,047 | 315,181 |
Long-term investments | 0 | 5,993 |
Equity securities, noncurrent | 9,815 | 23,522 |
Investments in preferred stock | 161,225 | 129,545 |
Property, plant and equipment, net | 112,674 | 64,672 |
Intangible assets, net | 232,877 | 225,615 |
Goodwill | 153,289 | 157,175 |
Investments in affiliates | 18,870 | 23,655 |
Other assets | 4,054 | 3,710 |
Total assets | 846,851 | 949,068 |
Current liabilities | ||
Accounts payable | 8,701 | 8,478 |
Accrued compensation and benefits | 6,474 | 6,540 |
Other accrued liabilities | 21,080 | 15,776 |
Deferred revenue | 42,870 | 53,364 |
Lines of credit | 233 | 820 |
Current portion of long term debt | 502 | 386 |
Deferred consideration | 0 | 8,801 |
Related party payables | 313 | 440 |
Total current liabilities | 80,173 | 94,605 |
Long term debt, net of current portion | 7,535 | 7,562 |
Deferred revenue, net of current portion | 193,527 | 256,778 |
Deferred tax liabilities, net | 15,620 | 17,007 |
Other long term liabilities | 3,451 | 3,868 |
Total liabilities | 300,306 | 379,820 |
Commitments and contingencies (Note 17) | ||
Total equity | ||
Common stock, no par value, 200,000,000 shares authorized as of December 31, 2017 and 2016; and 122,087,040 shares and 118,688,770 shares issued and outstanding as of December 31, 2017 and 2016, respectively | 0 | 0 |
Additional paid-in capital | 1,397,005 | 1,325,780 |
Accumulated deficit | (847,820) | (729,341) |
Accumulated other comprehensive loss | (15,554) | (36,202) |
Total Intrexon shareholders' equity | 533,631 | 560,237 |
Noncontrolling interests | 12,914 | 9,011 |
Total equity | 546,545 | 569,248 |
Total liabilities and total equity | $ 846,851 | $ 949,068 |
Consolidated Balance Sheets (Pa
Consolidated Balance Sheets (Parenthetical) - shares | Dec. 31, 2017 | Dec. 31, 2016 |
Statement of Financial Position [Abstract] | ||
Common stock, shares authorized | 200,000,000 | 200,000,000 |
Common stock, shares issued | 122,087,040 | 118,688,770 |
Common stock, shares outstanding | 122,087,040 | 118,688,770 |
Consolidated Statements of Oper
Consolidated Statements of Operations - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Revenues | |||
Collaboration and licensing revenues, including $130,670, $93,792, and $77,354 from related parties in 2017, 2016, and 2015, respectively | $ 145,579 | $ 109,871 | $ 87,821 |
Product revenues | 33,589 | 36,958 | 41,879 |
Service revenues | 50,611 | 43,049 | 42,923 |
Other revenues | 1,202 | 1,048 | 982 |
Total revenues | 230,981 | 190,926 | 173,605 |
Operating Expenses | |||
Cost of products | 33,263 | 37,709 | 40,746 |
Cost of services | 29,525 | 23,930 | 23,183 |
Research and development | 143,207 | 112,135 | 147,483 |
Selling, general and administrative | 146,103 | 142,318 | 109,057 |
Impairment loss | 16,773 | 0 | 0 |
Total operating expenses | 368,871 | 316,092 | 320,469 |
Operating loss | (137,890) | (125,166) | (146,864) |
Other Income (Expense), Net | |||
Unrealized and realized appreciation (depreciation) in fair value of equity securities and preferred stock | 2,586 | (58,894) | 66,876 |
Interest expense | (611) | (861) | (1,244) |
Interest and dividend income | 19,485 | 10,190 | 1,884 |
Other income, net | 1,013 | 1,700 | 1,314 |
Total other income (expense), net | 22,473 | (47,865) | 68,830 |
Equity in net loss of affiliates | (14,283) | (21,120) | (8,944) |
Loss before income taxes | (129,700) | (194,151) | (86,978) |
Income tax benefit (expense) | 2,880 | 3,877 | (1,016) |
Net loss | (126,820) | (190,274) | (87,994) |
Net loss attributable to the noncontrolling interests | 9,802 | 3,662 | 3,501 |
Net loss attributable to Intrexon | $ (117,018) | $ (186,612) | $ (84,493) |
Net loss attributable to Intrexon per share, basic and diluted | $ (0.98) | $ (1.58) | $ (0.76) |
Weighted average shares outstanding, basic and diluted | 119,998,826 | 117,983,836 | 111,066,352 |
Consolidated Statements of Ope5
Consolidated Statements of Operations (Parenthetical) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Related Party Transaction [Line Items] | |||
Collaboration and licensing revenues | $ 145,579 | $ 109,871 | $ 87,821 |
Related Parties, Aggregated | |||
Related Party Transaction [Line Items] | |||
Collaboration and licensing revenues | $ 130,670 | $ 93,792 | $ 77,354 |
Consolidated Statements of Comp
Consolidated Statements of Comprehensive Loss - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Statement of Comprehensive Income [Abstract] | |||
Net loss | $ (126,820) | $ (190,274) | $ (87,994) |
Other comprehensive income (loss): | |||
Unrealized gain (loss) on investments | 87 | 430 | (561) |
Gain (loss) on foreign currency translation adjustments | 20,599 | (23,901) | (12,108) |
Comprehensive loss | (106,134) | (213,745) | (100,663) |
Comprehensive loss attributable to the noncontrolling interests | 9,764 | 3,683 | 3,422 |
Comprehensive loss attributable to Intrexon | $ (96,370) | $ (210,062) | $ (97,241) |
Consolidated Statements of Shar
Consolidated Statements of Shareholders' and Total Equity - USD ($) $ in Thousands | Total | Common Stock | Additional Paid-in Capital | Accumulated Other Comprehensive Loss | Accumulated Deficit | Total Intrexon Shareholders' Equity | Noncontrolling Interests |
Beginning balance at Dec. 31, 2014 | $ 409,289 | $ 0 | $ 843,001 | $ (4) | $ (458,236) | $ 384,761 | $ 24,528 |
Beginning balance, shares at Dec. 31, 2014 | 100,557,932 | ||||||
Changes in Stockholders' Equity | |||||||
Stock-based compensation expense | 38,688 | 38,507 | 38,507 | 181 | |||
Exercises of stock options and warrants | 14,462 | 14,462 | 14,462 | 0 | |||
Exercises of stock options and warrants, shares | 1,148,463 | ||||||
Shares issued as payment for services | 2,169 | 2,169 | 2,169 | 0 | |||
Shares issued as payment for services, shares | 70,925 | ||||||
Shares issued in public or private offerings, net of issuance costs | 328,234 | 328,234 | 328,234 | 0 | |||
Shares issued in public or private offerings, net of issuance costs, shares | 9,922,256 | ||||||
Shares issued as consideration for license agreement | 59,579 | 59,579 | 59,579 | 0 | |||
Shares issued as consideration for license agreement, shares | 2,100,085 | ||||||
Shares issued in business combinations | 126,863 | 126,863 | 126,863 | 0 | |||
Shares issued in business combinations, shares | 2,552,151 | ||||||
Shares and warrants issued in business combination | 126,863 | ||||||
Shares issued in asset acquisition | 0 | ||||||
Shares issued as payment for contingent consideration | 0 | ||||||
Acquisition of noncontrolling interest | $ (1,566) | 9,412 | 9,412 | (10,978) | |||
Acquisition of noncontrolling interest, shares | 307,074 | ||||||
Adjustments for noncontrolling interests | $ 250 | (249) | (249) | 499 | |||
Noncash dividend | (172,419) | (172,419) | (172,419) | 0 | |||
Net loss | (87,994) | (84,493) | (84,493) | (3,501) | |||
Other comprehensive income (loss) | (12,669) | (12,748) | (12,748) | 79 | |||
Ending balance at Dec. 31, 2015 | 704,886 | 1,249,559 | (12,752) | (542,729) | 694,078 | 10,808 | |
Ending balance, shares at Dec. 31, 2015 | 116,658,886 | ||||||
Changes in Stockholders' Equity | |||||||
Stock-based compensation expense | 42,181 | 42,108 | 42,108 | 73 | |||
Exercises of stock options and warrants | 19,165 | 19,165 | 19,165 | 0 | |||
Exercises of stock options and warrants, shares | 1,400,146 | ||||||
Shares issued as payment for services | 10,777 | 10,777 | 10,777 | 0 | |||
Shares issued as payment for services, shares | 434,061 | ||||||
Shares and warrants issued in business combination | 0 | ||||||
Shares issued in asset acquisition | 4,401 | 4,401 | 4,401 | 0 | |||
Shares issued in asset acquisition, shares | 136,340 | ||||||
Shares issued as payment for contingent consideration | 1,583 | 1,583 | 1,583 | 0 | |||
Shares issued as payment for contingent consideration, shares | 59,337 | ||||||
Acquisition of noncontrolling interest | 0 | (1,813) | (1,813) | 1,813 | |||
Acquisition of noncontrolling interest, shares | 0 | ||||||
Net loss | (190,274) | (186,612) | (186,612) | (3,662) | |||
Other comprehensive income (loss) | (23,471) | (23,450) | (23,450) | (21) | |||
Ending balance at Dec. 31, 2016 | $ 569,248 | $ 0 | 1,325,780 | (36,202) | (729,341) | 560,237 | 9,011 |
Ending balance, shares at Dec. 31, 2016 | 118,688,770 | 118,688,770 | |||||
Changes in Stockholders' Equity | |||||||
Cumulative effect of adoption of ASU 2016-09 | $ 0 | 1,461 | (1,461) | 0 | 0 | ||
Stock-based compensation expense | 41,576 | 41,525 | 41,525 | 51 | |||
Exercises of stock options and warrants | 980 | 952 | 952 | 28 | |||
Exercises of stock options and warrants, shares | 149,429 | ||||||
Shares issued as payment for services | 11,118 | 11,118 | 11,118 | 0 | |||
Shares issued as payment for services, shares | 654,456 | ||||||
Shares issued in public or private offerings, net of issuance costs | 13,686 | 13,686 | 13,686 | 0 | |||
Shares issued in public or private offerings, net of issuance costs, shares | 1,207,980 | ||||||
Shares issued in business combinations, shares | 684,240 | ||||||
Shares and warrants issued in business combination | 16,997 | 16,997 | 16,997 | 0 | |||
Shares issued in asset acquisition | 0 | ||||||
Shares issued as payment for contingent consideration | 0 | 0 | 0 | 0 | |||
Shares issued as payment for contingent consideration, shares | 480,422 | ||||||
Acquisition of noncontrolling interest | (913) | 5,082 | 5,082 | (5,995) | |||
Acquisition of noncontrolling interest, shares | 221,743 | ||||||
Adjustments for noncontrolling interests | (13) | 2,789 | 2,789 | (2,802) | |||
Noncash dividend | 0 | (22,385) | (22,385) | 22,385 | |||
Net loss | (126,820) | (117,018) | (117,018) | (9,802) | |||
Other comprehensive income (loss) | 20,686 | 20,648 | 20,648 | 38 | |||
Ending balance at Dec. 31, 2017 | $ 546,545 | $ 1,397,005 | $ (15,554) | $ (847,820) | $ 533,631 | $ 12,914 | |
Ending balance, shares at Dec. 31, 2017 | 122,087,040 | 122,087,040 |
Consolidated Statements of Cash
Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Cash flows from operating activities | |||
Net loss | $ (126,820) | $ (190,274) | $ (87,994) |
Adjustments to reconcile net loss to net cash provided by (used in) operating activities: | |||
Depreciation and amortization | 31,145 | 24,572 | 17,743 |
Loss on disposal of long-lived assets | 3,124 | 666 | 633 |
Impairment loss | 16,773 | 0 | 0 |
Unrealized and realized (appreciation) depreciation on equity securities and preferred stock | (2,586) | 58,894 | (66,876) |
Noncash dividend income | (16,756) | (7,421) | 0 |
Amortization of premiums on investments | 411 | 1,070 | 642 |
Equity in net loss of affiliates | 14,283 | 21,120 | 8,944 |
Stock-based compensation expense | 41,576 | 42,202 | 38,667 |
Shares issued as payment for services | 11,118 | 10,777 | 2,169 |
Shares issued as consideration for license agreement | 0 | 0 | 59,579 |
Provision for bad debts | 1,217 | 1,963 | 1,757 |
Deferred income taxes | (2,528) | (3,467) | 1,117 |
Other noncash items | (517) | 1,662 | 460 |
Changes in operating assets and liabilities: | |||
Restricted cash | 0 | (6,987) | 0 |
Receivables: | |||
Trade | 740 | 2,588 | (12,138) |
Related parties | 631 | 6,804 | (11,042) |
Notes | 0 | (42) | 0 |
Other | 661 | 271 | 5,286 |
Inventory | 663 | 3,807 | (774) |
Prepaid expenses and other | 492 | (932) | (2,729) |
Other assets | (1,436) | 2,189 | (2,119) |
Accounts payable | (3,402) | 3,618 | (3,263) |
Accrued compensation and benefits | (1,466) | (12,402) | 10,491 |
Other accrued liabilities | 3,007 | 9,002 | 1,593 |
Deferred revenue | (75,337) | (25,481) | 74,434 |
Deferred consideration | (313) | (630) | (943) |
Related party payables | (147) | 310 | (64) |
Other long term liabilities | 1,328 | 146 | 96 |
Net cash provided by (used in) operating activities | (104,139) | (55,975) | 35,669 |
Cash flows from investing activities | |||
Purchases of investments | 0 | (75,246) | (181,572) |
Maturities of investments | 174,542 | 101,987 | 88,000 |
Purchases of equity securities, preferred stock, and warrants | (1,161) | (2,308) | (17,080) |
Proceeds from sales of equity securities | 235 | 280 | 0 |
Acquisitions of businesses, net of cash received | 2,054 | 0 | (123,928) |
Investments in affiliates | (11,189) | (11,542) | (13,442) |
Cash paid in asset acquisition | (14,219) | (7,244) | 0 |
Purchases of property, plant and equipment | (46,666) | (31,629) | (12,749) |
Proceeds from sale of property, plant and equipment | 1,636 | 274 | 626 |
Issuances of notes receivable | (2,400) | (2,964) | (600) |
Proceeds from repayment of notes receivable | 1,500 | 0 | 1,500 |
Net cash provided by (used in) investing activities | 104,332 | (28,392) | (259,245) |
Cash flows from financing activities | |||
Proceeds from issuance of shares in a private placement | 13,686 | 0 | 0 |
Proceeds from issuance of shares in public offerings, net of issuance costs | 0 | 0 | 328,234 |
Acquisitions of noncontrolling interests | (913) | 0 | (1,566) |
Advances from lines of credit | 5,906 | 5,075 | 15,232 |
Repayments of advances from lines of credit | (6,493) | (4,816) | (16,944) |
Proceeds from long term debt | 325 | 547 | 81 |
Payments of long term debt | (519) | (1,201) | (1,564) |
Payments of deferred consideration for acquisitions | (8,678) | (6,705) | (6,252) |
Proceeds from stock option exercises | 980 | 19,165 | 14,462 |
Payment of stock issuance costs | (10) | 0 | 0 |
Net cash provided by financing activities | 4,284 | 12,065 | 331,683 |
Effect of exchange rate changes on cash and cash equivalents | 1,027 | (873) | 209 |
Net increase (decrease) in cash and cash equivalents | 5,504 | (73,175) | 108,316 |
Cash and cash equivalents | |||
Beginning of period | 62,607 | 135,782 | 27,466 |
End of period | 68,111 | 62,607 | 135,782 |
Supplemental disclosure of cash flow information | |||
Cash paid during the period for interest | 617 | 964 | 1,195 |
Cash paid during the period for income taxes | 566 | 10 | 1,165 |
Significant noncash financing and investing activities | |||
Stock received as consideration for collaboration agreements | 0 | 18,766 | 9,149 |
Preferred stock received as consideration for collaboration amendments | 0 | 120,000 | 0 |
Receivables converted to preferred stock | 3,385 | 0 | 0 |
Stock and warrants issued in business combinations | 16,997 | 0 | 126,863 |
Stock issued to acquire noncontrolling interests | 5,082 | 0 | 9,412 |
Stock issued in asset acquisition | 0 | 4,401 | 0 |
Contingent consideration assumed in asset acquisition | 0 | 3,660 | 0 |
Stock issued as payment for contingent consideration | 0 | 1,583 | 0 |
Noncash dividend to shareholders | 22,385 | 0 | 172,419 |
Deferred consideration payable related to acquisition | 0 | 0 | 1,992 |
Purchases of equipment included in accounts payable and other accrued liabilities | 2,257 | 652 | 782 |
Receivable recorded in anticipation of dissolution of affiliate | 2,598 | 0 | 0 |
Transfer of inventory to breeding stock | $ 0 | $ 1,191 | $ 0 |
Organization and Basis of Prese
Organization and Basis of Presentation | 12 Months Ended |
Dec. 31, 2017 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
Organization and Basis of Presentation | Organization and Basis of Presentation Intrexon Corporation ("Intrexon"), a Virginia corporation, uses synthetic biology to focus on programming biological systems to alleviate disease, remediate environmental challenges, and provide sustainable food and industrial chemicals, which may be accomplished through collaborations and joint ventures. Intrexon's primary domestic operations are in California, Florida, Maryland, and Virginia, and its primary international operations are in Belgium and Hungary. There have been no commercialized products derived from Intrexon's collaborations to date. Trans Ova Genetics, L.C. ("Trans Ova"), a provider of advanced reproductive technologies and other genetic processes to cattle breeders and other producers, is a wholly owned subsidiary of Intrexon with primary operations in Iowa, Maryland, Missouri, Oklahoma and Texas. Oxitec Limited ("Oxitec"), a pioneering company in biological insect control solutions, is a wholly owned subsidiary of Intrexon with primary operations in England and Brazil. Intrexon Produce Holdings, Inc. ("IPHI") is a wholly owned subsidiary of Intrexon. Okanagan Specialty Fruits, Inc. ("Okanagan"), a company which developed and received regulatory approval for the world's first non-browning apple without the use of any flavor-altering chemical or antioxidant additives, is a wholly owned subsidiary of IPHI with primary operations in Canada. Fruit Orchard Holdings, Inc. ("FOHI") is a wholly owned subsidiary of IPHI with primary operations in Washington. ViaGen, L.C. ("ViaGen"), a provider of genetic preservation and cloning technologies, and Exemplar Genetics, LLC ("Exemplar"), a provider of genetically engineered swine for medical and genetic research, are wholly owned subsidiaries with primary operations in Texas and Iowa, respectively. In March 2017, Intrexon acquired the remaining 49% of the equity of Biological & Popular Culture, Inc. ("BioPop"), a California company developing artwork, children's toys and novelty goods that are derived from living organisms or enabled by synthetic biology for $900 in cash and 221,743 shares of Intrexon common stock valued at $5,082 . Upon closing this transaction, BioPop became a wholly owned subsidiary of Intrexon. As of December 31, 2017 , Intrexon owned approximately 58% of AquaBounty Technologies, Inc. ("AquaBounty"), a company focused on improving productivity in commercial aquaculture. In January 2017, in conjunction with the listing by AquaBounty of their common stock on the NASDAQ Stock Market, Intrexon purchased $25,000 of additional AquaBounty common stock and subsequently distributed shares of AquaBounty common stock as a dividend to Intrexon shareholders. See Notes 14 and 22 for additional discussion. Intrexon Corporation and its consolidated subsidiaries are hereinafter referred to as the "Company." These consolidated financial statements are presented in United States dollars and are prepared under accounting principles generally accepted in the United States of America ("U.S. GAAP"). |
Summary of Significant Accounti
Summary of Significant Accounting Policies | 12 Months Ended |
Dec. 31, 2017 | |
Accounting Policies [Abstract] | |
Summary of Significant Accounting Policies | Summary of Significant Accounting Policies Principles of Consolidation The accompanying consolidated financial statements reflect the operations of the Company and its subsidiaries. All intercompany accounts and transactions have been eliminated. Revenue Recognition The Company generates collaboration and licensing revenue through the execution of agreements with collaborators (known as exclusive channel collaborations, "ECC" or "ECCs") and licensing agreements whereby the collaborators or the licensee obtain exclusive access to the Company's proprietary technologies for use in the research, development and commercialization of products and/or treatments in a contractually specified field of use. Generally, the terms of these agreements provide that the Company receives some or all of the following: (i) upfront payments upon consummation of the agreement, (ii) reimbursements for costs incurred by the Company for research and development and/or manufacturing efforts related to specific applications provided for in the agreement, (iii) milestone payments upon the achievement of specified development, regulatory and commercial activities, and (iv) royalties on sales of products arising from the collaboration or licensing agreement. The Company's collaboration and licensing agreements typically contain multiple elements, or deliverables, including technology licenses, research and development services, and in certain cases manufacturing services. The Company identifies the deliverables within the agreements and evaluates which deliverables represent separate units of accounting. Analyzing the agreements to identify deliverables requires the use of judgment. A deliverable is considered a separate unit of accounting when the deliverable has value to the collaborator or licensee on a standalone basis based on the consideration of the relevant facts and circumstances for each agreement. Consideration received is allocated at the inception of the agreement to all identified units of accounting based on their relative selling price. When available, the relative selling price for each deliverable is determined using vendor specific objective evidence ("VSOE") of the selling price or third-party evidence of the selling price, if VSOE does not exist. If neither VSOE nor third-party evidence of the selling price exists, the Company uses its best estimate of the selling price for the deliverable. The amount of allocable consideration is limited to amounts that are fixed or determinable. The consideration received is allocated among the separate units of accounting, and the applicable revenue recognition criteria are applied to each of the separate units. The Company recognizes the revenue allocated to each unit of accounting as the Company delivers the related goods or services. If the Company determines that certain deliverables should be treated as a single unit of accounting, then the revenue is recognized using either a proportional performance or straight-line method, depending on whether the Company can reasonably estimate the level of effort required to complete its performance obligations under an arrangement and whether such performance obligations are provided on a best-efforts basis. As the Company cannot reasonably estimate its performance obligations related to its collaborators or licensees, the Company recognizes revenue on a straight-line basis over the period it expects to complete its performance obligations, which is reevaluated each reporting period. The terms of the Company's agreements may provide for milestone payments upon achievement of certain defined events. The Company applies the Milestone Method for recognizing milestone payments. Under the Milestone Method, the Company recognizes consideration that is contingent upon the achievement of a milestone in its entirety as revenue in the period in which the milestone is achieved only if the milestone is substantive in its entirety. A milestone is considered substantive when it meets all of the following criteria: (1) The consideration is commensurate with either the entity's performance to achieve the milestone or the enhancement of the value of the delivered item or items as a result of a specific outcome resulting from the entity's performance to achieve the milestone; (2) The consideration relates solely to past performance; and (3) The consideration is reasonable relative to all of the deliverables and payment terms within the arrangement. In the event that a milestone is not considered substantive, the Company recognizes the milestone consideration as revenue using the same method applied to upfront payments. Research and development services are a deliverable satisfied by the Company in accordance with the terms of the collaboration and licensing agreements and the Company considers these services to be inseparable from the license to the core technology; therefore, reimbursements of services performed are recognized as revenue. Because reimbursement (i) is contingent upon performance of the services by the Company, (ii) does not include a profit component, and (iii) does not relate to any future deliverable, the revenue is recognized during the period in which the related services are performed and collection of such amounts is reasonably assured. Payments received for manufacturing services will be recognized when the earnings process related to the manufactured materials has been completed. Royalties to be received under the agreements will be recognized as earned. From time to time, the Company and certain collaborators may cancel their agreements, relieving the Company of any further performance obligations under the agreement. When no further performance obligations are required of the Company under an agreement, the Company recognizes any remaining deferred revenue. The Company generates product and service revenues primarily through sales of products and services which are created from technologies developed or owned by the Company. The Company's current offerings include sales of advanced reproductive technologies, including the Company's bovine embryo transfer and in vitro fertilization processes and from genetic preservation and sexed semen processes and applications of such processes to other livestock, as well as sales of livestock and embryos produced using these processes and used in production. Revenue is recognized when (i) persuasive evidence of an arrangement exists, (ii) services have been rendered or delivery has occurred such that risk of loss has passed to the customer, (iii) the price is fixed or determinable, and (iv) collection from the customer is reasonably assured. Research and Development The Company considers that regulatory requirements inherent in the research and development of new products preclude it from capitalizing such costs. Research and development expenses include salaries and related costs of research and development personnel, including stock-based compensation expense, and the costs of consultants, certain in-licensed technology rights, facilities, materials and supplies associated with research and development projects as well as various laboratory studies. Indirect research and development costs include depreciation, amortization and other indirect overhead expenses. The Company has research and development arrangements with third parties that include upfront and milestone payments. As of December 31, 2017 and 2016 , the Company had research and development commitments with third parties that had not yet been incurred totaling $10,682 and $10,631 , respectively. The commitments are generally cancellable by the Company at any time upon written notice. Cash and Cash Equivalents All highly liquid investments with an original maturity of three months or less at the date of purchase are considered to be cash equivalents. Cash balances at a limited number of banks may periodically exceed insurable amounts. The Company believes that it mitigates its risk by investing in or through major financial institutions with high quality credit ratings. Recoverability of investments is dependent upon the performance of the issuer. As of December 31, 2017 and 2016 , the Company had cash equivalent investments in highly liquid money market accounts at major financial institutions of $43,012 and $43,808 , respectively. Restricted Cash Restricted cash represents funds deposited with the U.S. Treasury, as required by a court decision resulting from litigation against Trans Ova (Note 17 ). Short-term and Long-term Investments As of December 31, 2017 , short-term investments include U.S. government debt securities and certificates of deposit. The Company determines the appropriate classification as short-term or long-term at the time of purchase based on original maturities and management's reasonable expectation of sales and redemption. The Company reevaluates such classification at each balance sheet date. The Company's written investment policy requires investments to be explicitly rated by two of the three following rating services: Standard & Poor's, Moody's and/or Fitch and to have a minimum rating of A1, P1 and/or F-1, respectively, from those agencies. In addition, the investment policy limits the amount of credit exposure to any one issuer. Equity Securities The Company holds equity securities received and/or purchased from certain collaborators. Other than investments accounted for using the equity method, the Company elected the fair value option to account for its equity securities held in these collaborators. These equity securities are recorded at fair value at each reporting date and are subject to market price volatility. Unrealized gains and losses resulting from fair value adjustments are reported in the consolidated statement of operations. The fair value of these equity securities is subject to fluctuation in the future due to the volatility of the stock market, changes in general economic conditions and changes in the financial conditions of these collaborators. Equity securities that the Company does not intend to sell within one year are classified as noncurrent in the consolidated balance sheet. The Company records the fair value of securities received on the date the collaboration is consummated or the milestone is achieved using the closing, quoted price of the collaborator's security on that date, assuming the transfer of consideration is considered perfunctory. If the transfer of the consideration is not considered perfunctory, the Company considers the specific facts and circumstances to determine the appropriate date on which to evaluate fair value. The Company also evaluates whether any discounts for trading restrictions or other basis for lack of marketability should be applied to the fair value of the securities at inception of the collaboration. In the event the Company concludes that a discount should be applied, the fair value of the securities is adjusted at inception of the collaboration and re-evaluated at each reporting period thereafter. Investments in Preferred Stock The Company holds preferred stock in certain of its collaborators, most of which may be converted to common stock as described in Note 7 . The Company elected the fair value option to account for its investments in preferred stock whereby the value of preferred stock is adjusted to fair value as of each reporting date and unrealized gains and losses are reported in the consolidated statement of operations. These investments are subject to fluctuation in the future due to, among other things, the likelihood and timing of conversion of certain of the preferred stock into common stock, the volatility of each collaborator's common stock, and changes in general economic and financial conditions of the collaborators. The investments are classified as noncurrent in the consolidated balance sheet since the Company does not intend to sell the investments nor expect the investments that are convertible into common stock to be converted within one year. The Company is entitled to monthly dividends and records dividend income as described in Note 7 . Fair Value of Financial Instruments Fair value is the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset and liability. As a basis for considering such assumptions, the Company uses a three-tier fair value hierarchy that prioritizes the inputs used in its fair value measurements. The hierarchy gives the highest priority to unadjusted quoted prices in active markets for identical assets or liabilities (Level 1 measurements) and the lowest priority to unobservable inputs (Level 3 measurements). The three levels of the fair value hierarchy are as follows: Level 1: Quoted prices in active markets for identical assets and liabilities; Level 2: Other than quoted prices included in Level 1 inputs that are observable for the asset or liability, either directly or indirectly; and Level 3: Unobservable inputs for the asset or liability used to measure fair value to the extent that observable inputs are not available. Concentrations of Risk Due to the Company's mix of fixed and variable rate securities holdings, the Company's investment portfolio is susceptible to changes in interest rates. As of December 31, 2017 , gross unrealized losses on the Company's short-term investments were not material. From time to time, the Company may liquidate some or all of its investments to fund operational needs or other activities, such as capital expenditures or business acquisitions, or distribute its equity securities to shareholders as a stock dividend. Depending on which investments the Company liquidates to fund these activities, the Company could recognize a portion, or all, of the gross unrealized losses. Financial instruments which potentially subject the Company to concentrations of credit risk consist primarily of trade and related party receivables. The Company controls credit risk through credit approvals, credit limits and monitoring procedures. The Company performs ongoing credit evaluations of its customers but generally does not require collateral to support accounts receivable. Equity Method Investments The Company accounts for its investments in each of its joint ventures and for its investments in start-up entities backed by the Harvest Intrexon Enterprise Fund I, LP ("Harvest"), a related party, (Note 18 ) using the equity method of accounting based upon relative ownership interest. The Company's investments in these entities are included in investments in affiliates in the accompanying consolidated balance sheets. The Company accounts for its investment in Oragenics, Inc. ("Oragenics"), one of its collaborators, using the fair value option. The fair value of the Company's investment in Oragenics was $3,085 and $7,244 as of December 31, 2017 and 2016 , respectively, and is included as equity securities in the accompanying consolidated balance sheets. The Company's ownership of Oragenics was 29.4% and 29.5% as of December 31, 2017 and 2016 , respectively. Unrealized appreciation (depreciation) in the fair value of these securities was $(4,159) , $(10,523) , and $4,863 for the years ended December 31, 2017 , 2016 , and 2015 , respectively. See Note 7 for additional discussion regarding Oragenics. In 2015, the Company determined that ZIOPHARM Oncology, Inc. ("ZIOPHARM") met the criteria of SEC Regulation S-X Article 3-09 for inclusion of separate financial statements of an equity method investment as the Company determined it had significant influence over ZIOPHARM until the Company distributed its share of ZIOPHARM common stock to shareholders in the form of a special stock dividend (Note 14 ). Upon disposition, the Company realized a gain of $81,401 during the year ended December 31, 2015. Summarized financial data as of December 31, 2017 and 2016 , and for the years ended December 31, 2017 , 2016 , and 2015 , for the Company's equity method investments for which separate financial statements are not included, pursuant to SEC Regulation S-X Article 3-09, are shown in the following tables. December 31, 2017 2016 Current assets $ 61,086 $ 77,761 Non-current assets 13,598 11,040 Total assets 74,684 88,801 Current liabilities 6,213 11,588 Net assets $ 68,471 $ 77,213 Year Ended December 31, 2017 2016 2015 Revenues, net $ 254 $ 417 $ 1,176 Operating expenses 41,904 62,373 32,513 Operating loss (41,650 ) (61,956 ) (31,337 ) Other, net (8 ) 1,535 (64 ) Net loss $ (41,658 ) $ (60,421 ) $ (31,401 ) Variable Interest Entities The Company identifies entities that (i) do not have sufficient equity investment at risk to permit the entity to finance its activities without additional subordinated financial support or (ii) in which the equity investors lack an essential characteristic of a controlling financial interest as variable interest entities ("VIE" or "VIEs"). The Company performs an initial and on-going evaluation of the entities with which the Company has variable interests to determine if any of these entities are VIEs. If an entity is identified as a VIE, the Company performs an assessment to determine whether the Company has both (i) the power to direct activities that most significantly impact the VIE's economic performance and (ii) have the obligation to absorb losses from or the right to receive benefits of the VIE that could potentially be significant to the VIE. If both of these criteria are satisfied, the Company is identified as the primary beneficiary of the VIE. As of December 31, 2017 and 2016 , the Company determined that certain of its collaborators and joint ventures as well as Harvest were VIEs. The Company was not the primary beneficiary for these entities since it did not have the power to direct the activities that most significantly impact the economic performance of the VIEs. The Company's aggregate investment balances of these VIEs as of December 31, 2017 and 2016 , were $185,261 and $159,115 , respectively, which represents the Company's maximum risk of loss related to the identified VIEs. Trade Receivables Trade receivables consist of credit extended to the Company's customers in the normal course of business and are reported net of an allowance for doubtful accounts. The Company reviews its customer accounts on a periodic basis and records bad debt expense for specific amounts the Company evaluates as uncollectible. Past due status is determined based upon contractual terms. Amounts are written off at the point when collection attempts have been exhausted. Management estimates uncollectible amounts considering such factors as current economic conditions and historic and anticipated customer performance. This estimate can fluctuate due to changes in economic, industry or specific customer conditions which may require adjustment to the allowance recorded by the Company. Management has included amounts believed to be uncollectible in the allowance for doubtful accounts. The following table shows the activity in the allowance for doubtful receivable accounts for the years ended December 31, 2017 , 2016 , and 2015 : 2017 2016 2015 Beginning balance $ 3,703 $ 2,081 $ 565 Charged to operating expenses 1,217 1,963 1,757 Write offs of accounts receivable, net of recoveries (289 ) (341 ) (241 ) Ending balance $ 4,631 $ 3,703 $ 2,081 Inventory The Company's inventory primarily includes adult female cows which are used in certain production processes and are recorded at acquisition cost using the first-in, first-out method or at market, whichever is lower. Work-in-process inventory includes allocations of production costs and facility costs for products currently in production and is recorded at the lower of cost or market. Significant declines in the price of cows could result in unfavorable adjustments to inventory balances. Property, Plant and Equipment Property, plant and equipment are stated at cost, less accumulated depreciation and amortization. Major additions or betterments are capitalized and repairs and maintenance are generally expensed as incurred. Depreciation and amortization is calculated using the straight-line method over the estimated useful lives of the assets. The estimated useful lives of these assets are as follows: Years Land improvements 4–20 Buildings and building improvements 3–25 Furniture and fixtures 1–10 Equipment 1–10 Breeding stock 1–4 Computer hardware and software 1–7 Leasehold improvements are amortized over the shorter of the useful life of the asset or the applicable lease term, generally one to twenty years . Goodwill Goodwill represents the future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized. Goodwill is reviewed for impairment at least annually. The Company performs a qualitative assessment to determine whether it is more-likely-than-not that the fair value of a reporting unit is less than its carrying amount prior to performing the goodwill impairment test. If this is the case, the goodwill impairment test is required. If it is more-likely-than-not that the fair value of a reporting unit is greater than the carrying amount, the goodwill impairment test is not required. If the goodwill impairment test is required, first, the fair value of the reporting unit is compared with its carrying amount (including goodwill). If the fair value of the reporting unit is less than its carrying amount, an indication of goodwill impairment exists for the reporting unit and the entity must record the impairment charge for the excess carrying amount, which is limited to the amount of goodwill allocated to the reporting unit. If the fair value of the reporting unit exceeds its carrying amount, no goodwill impairment charge is necessary. The Company performs its annual impairment review of goodwill in the fourth quarter, or sooner if a triggering event occurs prior to the annual impairment review. See Note 11 for additional discussion regarding the results of this review for the year ended December 31, 2017 . Intangible Assets Intangible assets subject to amortization consist of patents, developed technologies and know-how; customer relationships; and trademarks acquired as a result of mergers and acquisitions. These intangible assets are subject to amortization, were recorded at fair value at the date of acquisition and are stated net of accumulated amortization. Indefinite-lived intangible assets consist of in-process research and development technologies acquired in mergers or acquisitions and were recorded at fair value at the dates of the respective acquisitions. The Company amortizes long-lived intangible assets to reflect the pattern in which the economic benefits of the intangible asset are expected to be realized. The intangible assets are amortized over their estimated useful lives, ranging from three to twenty-one years for the patents, developed technologies and know-how; customer relationships; and trademarks. Impairment of Long-Lived Assets Long-lived assets to be held and used, including property, plant and equipment and intangible assets subject to amortization, are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of the assets may not be recoverable. Conditions that would necessitate an impairment assessment include a significant decline in the observable market value of an asset, a significant change in the extent or manner in which an asset is used, or a significant adverse change that would indicate that the carrying amount of an asset or group of assets is not recoverable. Indefinite-lived intangible assets, including in-process research and development, are tested for impairment annually, or more frequently if events or circumstances between annual tests indicate that the asset may be impaired. Impairment losses on indefinite-lived intangible assets are recognized based solely on a comparison of their fair value to carrying value, without consideration of any recoverability test. The Company monitors the progression of its in-process research and development, as the likelihood of success is contingent upon commercial development or regulatory approval. Self-insurance Reserves Effective January 1, 2017, the Company commenced a self-insurance program for a significant portion of its employee health benefit programs. The Company maintains stop-loss coverage with third party insurers to limit its individual claims and total exposure under those programs. The Company estimates its accrued liability for the ultimate costs to close known claims, including claims incurred but not yet reported to the Company, as of the balance sheet date. The Company's recorded estimated liability for self-insurance is based on the insurance company's incurred loss estimates and management's judgment, including assumptions and factors related to the frequency and severity of claims and the Company's claims development history. The assessment of self-insurance reserves is a highly subjective process that requires judgments about future events. Self-insurance reserves are reviewed at least quarterly to determine the adequacy of the accruals and related financial statement disclosure. The ultimate settlement of self-insurance reserves may differ significantly from amounts the Company has accrued in its consolidated financial statements. Foreign Currency Translation The assets and liabilities of foreign subsidiaries, where the local currency is the functional currency, are translated from their respective functional currencies into United States dollars at the exchange rates in effect at the balance sheet date, with resulting foreign currency translation adjustments recorded in the consolidated statement of comprehensive loss. Revenue and expense amounts are translated at average rates during the period. Income Taxes Income taxes are accounted for under the asset and liability method. Deferred tax assets and liabilities are recognized for the future tax consequences attributable to both differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases as well as operating loss and tax credit carryforwards. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date of the change. Valuation allowances are established when necessary to reduce deferred tax assets to the amount expected to be realized. The Company identifies any uncertain income tax positions and recognizes the effect of income tax positions only if those positions are more likely than not of being sustained. Recognized income tax positions are measured at the largest amount that is greater than 50% likely of being realized. Changes in recognition or measurement are reflected in the period in which the change in judgment occurs. The Company records interest, if any, related to unrecognized tax benefits as a component of interest expense. Penalties, if any, are recorded in selling, general and administrative expenses. On December 22, 2017, the Tax Cuts and Jobs Act (the "Tax Act") was signed into law and significantly revised U.S. corporate income tax law by, among other things, reducing the corporate income tax rate to 21% effective January 1, 2018, eliminating the corporate alternative minimum tax and implementing a modified territorial tax system that includes a one-time transition tax on deemed repatriated earnings foreign subsidiaries. The SEC Staff issued Staff Accounting Bulletin No. 118 ("SAB 118") to address the application of U.S. GAAP in situations when a registrant does not have the necessary information available, prepared, or analyzed, including computations, in reasonable detail to complete the accounting for certain income tax effects of the Tax Act. The Company has recognized provisional tax impacts related to revaluation of most of the Company's domestic deferred tax assets, the impact of revaluation of those deferred tax assets on the Company's valuation allowance and elimination of the corporate alternative minimum tax, and included those amounts in the consolidated financial statements for the year ended December 31, 2017. The actual impact of the Tax Act may differ from the Company's estimates due to, among other things, changes in interpretations and assumptions made, and guidance that may be issued as a result of the Tax Act. In addition, the Tax Act implemented a new minimum tax on global intangible low-taxed income ("GILTI"). A company can elect an accounting policy to account for GILTI in either of the following ways: • As a period charge in the future period the tax arises; or • As part of deferred taxes related to the investment or subsidiary. The Company is currently in the process of analyzing this provision and, as a result, is not yet able to reasonably estimate its effect. Therefore, the Company has not made any provisional adjustments related to potential GILTI tax in its consolidated financial statements and has not made a policy decision regarding whether to record deferred taxes under the GILTI regime. The accounting is expected to be completed within the one-year measurement period as allowed by SAB 118 for items impacted or introduced by the Tax Act. Share-Based Payments Intrexon uses the Black-Scholes option pricing model to estimate the grant-date fair value of all stock options. The Black-Scholes option pricing model requires the use of assumptions for estimated expected volatility, estimated expected term of stock options, risk-free rate, estimated expected dividend yield, and the fair value of the underlying common stock at the date of grant. Since Intrexon does not have sufficient history to estimate the expected volatility of its common stock price, expected volatility is based on a blended approach which utilizes the volatility of Intrexon's common stock and the volatility of peer public entities that are similar in size and industry. Intrexon estimates the expected term of all options based on previous history of exercises. The risk-free rate is based on the U.S. Treasury yield curve in effect at the time of grant for the expected term of the option. The expected dividend yield is 0% as Intrexon does not expect to declare cash dividends in the near future. The fair value of the underlying common stock is determined based on the quoted market price on the New York Stock Exchange. Forfeitures are recorded when incurred. The assumptions used in the Black-Scholes option pricing model for the years ended December 31, 2017 , 2016 and 2015 are set forth in the table below: 2017 2016 2015 Valuation assumptions Expected dividend yield 0% 0% 0% Expected volatility 57%—60% 59%—60% 59%—62% Expected term (years) 6.25 6.25 6.25 Risk-free interest rate 1.89%—2.27% 1.23%—2.17% 1.56%—1.95% Net Loss per Share Basic net loss per share is calculated by dividing net loss attributable to common shareholders by the weighted average shares outstanding during the period, without consideration of common stock equivalents. Diluted net loss per share is calculated by adjusting weighted average shares outstanding for the dilutive effect of common stock equivalents outstanding for the period, using the treasury-stock method. For purposes of the diluted net loss per share calculation, stock options and warrants are considered to be common stock equivalents but are excluded from the calculation of diluted net loss per share because their effect would be anti-dilutive and, therefore, basic and diluted net loss per share were the same for all periods presented. Segment Information While the Company generates revenues from multiple sources, including collaboration agreements, licensing, and products and services primarily associated with bovine reproduction, management is organized around a singular research and development focus to further the development of the Company's underlying synthetic biology technologies. Accordingly, the Company has determined that it operates in one segment. As of December 31, 2017 and 2016 , the Company had $21,837 and $13,265 , respectively, of long-lived assets in foreign countries. The Company recognized revenues derived in foreign countrie |
Mergers and Acquisitions
Mergers and Acquisitions | 12 Months Ended |
Dec. 31, 2017 | |
Business Combinations [Abstract] | |
Mergers and Acquisitions | Mergers and Acquisitions GenVec Acquisition In June 2017, pursuant to an Agreement and Plan of Merger (the "GenVec Merger Agreement"), the Company acquired 100% of the outstanding shares of GenVec, Inc. ("GenVec"), a clinical-stage company and pioneer in the development of AdenoVerse gene delivery technology. Pursuant to the GenVec Merger Agreement, the former shareholders of GenVec received an aggregate of 684,240 shares of the Company's common stock and have the right to receive contingent consideration equal to 50% of any milestone or royalty payments received under one of GenVec's collaboration agreements, provided such payments are received within three years after the closing of the transaction. The Company also assumed warrants held by certain former shareholders of GenVec. The results of GenVec's operations subsequent to the acquisition date have been included in the consolidated financial statements. The fair value of the total consideration transferred was $17,582 . The acquisition date fair value of each class of consideration transferred is presented below: Common shares $ 15,616 Warrants 1,381 Contingent consideration 585 $ 17,582 The fair value of the shares of the Company's common stock issued was based on the quoted closing price of the Company's common stock immediately prior to the closing of the acquisition. The fair value of the warrants assumed was estimated using the Black-Scholes option-pricing model. The fair value of the contingent consideration was determined using a probability weighted discounted cash flows model and is considered a freestanding financial instrument and recorded at fair value each reporting period. The estimated fair value of assets acquired and liabilities assumed at the acquisition date is shown below: Cash and cash equivalents $ 2,054 Short term investments 542 Trade receivables 75 Other receivables 97 Prepaid expenses and other 227 Property and equipment 250 Intangible assets 14,000 Other noncurrent assets 58 Total assets acquired 17,303 Accounts payable 2,158 Accrued compensation and benefits 1,226 Other accrued expenses 856 Other long term liabilities 92 Deferred tax liabilities 239 Total liabilities assumed 4,571 Net assets acquired 12,732 Goodwill 4,850 Total consideration $ 17,582 The acquired intangible assets include developed technology, the fair value of which was determined using the multi-period excess earning method, which is a variation of the income approach that converts future cash flows to single discounted present value amounts. The intangible assets are being amortized over a useful life of eleven years . Goodwill, which is not deductible for tax purposes, represents the assembled workforce and the anticipated buyer-specific synergies arising from the combination of the Company's and GenVec's technology. Acquisition-related costs totaling $ 507 and $ 12 are included in selling, general and administrative expenses in the accompanying consolidated statements of operations for the years ended December 31, 2017 and 2016 , respectively. Oxitec Acquisition In September 2015, pursuant to a Stock Purchase Agreement (the "Oxitec Purchase Agreement"), the Company acquired 100% of the issued outstanding share capital of Oxitec. The aggregated consideration paid consisted of (i) 1,359,343 shares of the Company's common stock (the "Stock Consideration") and (ii) $ 90,199 in cash (the "Cash Consideration"), inclusive of net cash and working capital adjustments as defined in the Oxitec Purchase Agreement totaling $9,449 . Stock Consideration totaling 480,422 shares and Cash Consideration totaling $1,991 were withheld as escrow at closing and were issued and paid, respectively, in March 2017. The results of Oxitec's operations subsequent to the acquisition date have been included in the consolidated financial statements. The fair value of the total consideration transferred was $ 146,394 . The acquisition date fair value of the Stock Consideration and Cash Consideration is presented below: Cash $ 90,199 Common shares 56,195 $ 146,394 The fair value of the shares of the Company common stock issued was based on the quoted closing price of the Company's common stock as of the closing date of the acquisition. The estimated fair value of assets acquired and liabilities assumed at the acquisition date is shown below: Cash $ 3,780 Trade receivables 125 Other receivables 7,395 Prepaid expenses and other 121 Property, plant, and equipment 1,198 Intangible assets 96,854 Total assets acquired 109,473 Accounts payable 1,187 Accrued compensation and benefits 246 Other accrued liabilities 210 Deferred revenue 120 Deferred tax liabilities 12,584 Total liabilities assumed 14,347 Net assets acquired 95,126 Goodwill 51,268 Total consideration $ 146,394 The acquired intangible assets primarily include in-process research and development, the fair value of which was determined using the multi-period excess earning method, which is a variation of the income approach that converts future cash flows to single discounted present value amounts. In November 2016, the Company re-evaluated certain of the acquired in-process research and development technology and determined it was placed in service as developed technology and began amortizing the original amount capitalized using a useful life of eighteen years . Goodwill, which is not deductible for tax purposes, represents the assembled workforce and the potential for future Oxitec products and technologies. Acquisition-related costs totaling $ 1,675 are included in selling, general and administrative expenses in the accompanying consolidated statement of operations for the year ended December 31, 2015. Okanagan Acquisition In April 2015, pursuant to a Stock Purchase Agreement (the "Okanagan Purchase Agreement"), the Company acquired 100% of the outstanding shares of Okanagan. Pursuant to the Okanagan Purchase Agreement, the former shareholders of Okanagan received an aggregate of 707,853 shares of the Company's common stock and $10,000 cash in exchange for all shares in Okanagan. The results of Okanagan's operations subsequent to the acquisition date have been included in the consolidated financial statements. The fair value of the total consideration transferred was $40,933 . The acquisition date fair value of each class of consideration transferred is presented below: Cash $ 10,000 Common shares 30,933 $ 40,933 The fair value of the shares of the Company's common stock issued was based on the quoted closing price of the Company's common stock as of the closing date of the acquisition. The estimated fair value of assets acquired and liabilities assumed at the acquisition date is shown below: Cash $ 58 Trade receivables 16 Other receivables 49 Property, plant, and equipment 32 Intangible assets 36,500 Total assets acquired 36,655 Accounts payable 181 Deferred revenue 181 Deferred tax liabilities 8,847 Total liabilities assumed 9,209 Net assets acquired 27,446 Goodwill 13,487 Total consideration $ 40,933 The acquired intangible assets primarily include developed technology, patents and know-how and the fair values of the acquired assets were determined using the with-and-without method, which is a variation of the income approach that utilizes estimated cash flows with all assets in place at the valuation date and estimated cash flows with all assets in place except the intangible assets at the valuation date. The intangible assets are being amortized over a useful life of fourteen years . Goodwill, which is not deductible for tax purposes, represents potential future applications of Okanagan's technology to other fruits, including additional apple varietals, and anticipated buyer-specific synergies arising from the combination of the Company's and Okanagan's technologies. Acquisition-related costs totaling $267 are included in selling, general and administrative expenses in the accompanying consolidated statement of operations for the year ended December 31, 2015. ActoGeniX Acquisition In February 2015, the Company acquired 100% of the membership interests of ActoGeniX NV ("ActoGeniX"), a European biopharmaceutical company, pursuant to a Stock Purchase Agreement (the "ActoGeniX Purchase Agreement"). ActoGeniX's platform technology complements the Company's suite of proprietary technologies available for current and future collaborators. Pursuant to the ActoGeniX Purchase Agreement, the former members of ActoGeniX received an aggregate of 965,377 shares of the Company's common stock and $ 32,739 in cash in exchange for all membership interests of ActoGeniX. The results of ActoGeniX's operations subsequent to the acquisition date have been included in the consolidated financial statements. The fair value of the total consideration transferred was $ 72,474 . The acquisition date fair value of each class of consideration transferred is presented below: Cash $ 32,739 Common shares 39,735 $ 72,474 The fair value of the shares of the Company's common stock issued was based on the quoted closing price of the Company's common stock as of the closing date of the acquisition. The estimated fair value of assets acquired and liabilities assumed at the acquisition date is shown below: Cash $ 3,180 Other receivables 305 Prepaid expenses and other 31 Property, plant and equipment 209 Intangible assets 68,100 Other noncurrent assets 23 Total assets acquired 71,848 Accounts payable 230 Accrued compensation and benefits 196 Other accrued liabilities 253 Deferred revenue 732 Deferred tax liabilities 612 Total liabilities assumed 2,023 Net assets acquired 69,825 Goodwill 2,649 Total consideration $ 72,474 The acquired intangible assets primarily include in-process research and development, the fair value of which was determined using the multi-period excess earnings and with-and-without methods, which are both variations of the income approach that convert future cash flows to single discounted present value amounts. In August 2015, the Company re-evaluated the acquired in-process research and development technology and determined that it was placed in service as developed technology and began amortizing the original amount capitalized using a useful life of eighteen years . Goodwill, which is not deductible for tax purposes, represents the assembled workforce and anticipated buyer-specific synergies arising from the combination of the Company's and ActoGeniX's technologies. Acquisition-related costs totaling $ 381 are included in selling, general and administrative expenses in the accompanying consolidated statement of operations for the year ended December 31, 2015. Unaudited Condensed Pro Forma Financial Information GenVec's results of operations subsequent to the acquisition are included in the consolidated statement of operations. The following unaudited condensed pro forma financial information for the years ended December 31, 2017 and 2016, is presented as if the acquisition had been consummated on January 1, 2016: Year Ended December 31, 2017 2016 Pro Forma Revenues $ 231,213 $ 191,437 Loss before income taxes (136,966 ) (201,210 ) Net loss (134,275 ) (197,144 ) Net loss attributable to the noncontrolling interests 9,802 3,662 Net loss attributable to Intrexon (124,473 ) (193,482 ) The results of operations of the 2015 acquisitions discussed above subsequent to the acquisitions are included in the consolidated statement of operations. The following unaudited condensed pro forma financial information for the year ended December 31, 2015 is presented as if the 2015 acquisitions had been consummated on January 1, 2014: Year Ended December 31, 2015 Pro Forma Revenues $ 174,558 Loss before income taxes (99,751 ) Net loss (99,594 ) Net loss attributable to the noncontrolling interests 3,501 Net loss attributable to Intrexon (96,093 ) |
Investments in Joint Ventures
Investments in Joint Ventures | 12 Months Ended |
Dec. 31, 2017 | |
Equity Method Investments and Joint Ventures [Abstract] | |
Investments in Joint Ventures | Investments in Joint Ventures S & I Ophthalmic In September 2013, the Company entered into a Limited Liability Company Agreement ("Sun LLC Agreement") with Sun Pharmaceutical Industries, Inc. ("Sun Pharmaceutical Subsidiary"), an indirect subsidiary of Sun Pharmaceutical Industries Ltd. ("Sun Pharmaceutical"), an international specialty pharmaceutical company focused on chronic diseases, to form S & I Ophthalmic, LLC ("S & I Ophthalmic"). The Sun LLC Agreement governs the affairs and the conduct of business of S & I Ophthalmic. S & I Ophthalmic leverages experience and technology from both the Company and Sun Pharmaceutical. Both the Company and Sun Pharmaceutical Subsidiary made an initial capital contribution of $5,000 in October 2013 for a 50% membership interest in S & I Ophthalmic. S & I Ophthalmic is governed by a board of managers which has four members, two each from the Company and Sun Pharmaceutical Subsidiary. In 2015, both the Company and Sun Pharmaceutical Subsidiary made subsequent capital contributions of $5,000 . In December 2017, both the Company and Sun Pharmaceutical Subsidiary agreed to dissolve S & I Ophthalmic and terminate the related ECC agreement. The Company is entitled to receive $2,598 upon the dissolution of S & I Ophthalmic which represents the Company's portion of S & I Ophthalmic's remaining cash after all liabilities are settled and is included in related party receivables in the accompanying consolidated balance sheet as of December 31, 2017 . The Company's investment in S & I Ophthalmic was $3,236 as of December 31, 2016 and is included in investments in affiliates in the accompanying consolidated balance sheet. OvaXon In December 2013, the Company and OvaScience, Inc. ("OvaScience"), a life sciences company focused on the discovery, development and commercialization of new treatments for infertility, entered into a Limited Liability Company Agreement ("OvaXon LLC Agreement") to form OvaXon, LLC ("OvaXon"), a joint venture to create new applications for improving human and animal health. Both the Company and OvaScience made an initial capital contribution of $1,500 in January 2014 for a 50% membership interest in OvaXon. OvaXon is governed by the OvaXon board of managers ("OvaXon Board") which has four members, two each from the Company and OvaScience. In cases in which the OvaXon Board determines that additional capital contributions are necessary in order for OvaXon to conduct business and comply with its obligations, each of the Company and OvaScience has the right, but not the obligation, to make additional capital contributions to OvaXon subject to the OvaXon LLC Agreement. Through December 31, 2017 , both the Company and OvaScience have made subsequent capital contributions of $4,350 . The Company's investment in OvaXon was $146 and $65 as of December 31, 2017 and 2016 , respectively, and is included in investments in affiliates in the accompanying consolidated balance sheets. See additional discussion in Note 22 . Intrexon Energy Partners In March 2014, the Company and certain investors (the "IEP Investors"), including an affiliate of Third Security, LLC ("Third Security"), entered into a Limited Liability Company Agreement which governs the affairs and conduct of business of Intrexon Energy Partners, LLC ("Intrexon Energy Partners"), a joint venture formed to optimize and scale-up the Company's methane bioconversion platform ("MBP") technology for the production of certain fuels and lubricants. The Company also entered into an ECC with Intrexon Energy Partners providing exclusive rights to the Company's technology for the use in bioconversion, as a result of which the Company received a technology access fee of $25,000 while retaining a 50% membership interest in Intrexon Energy Partners. The IEP Investors made initial capital contributions, totaling $25,000 in the aggregate, in exchange for pro rata membership interests in Intrexon Energy Partners totaling 50% . In addition, Intrexon has committed to make capital contributions of up to $25,000 , and the IEP Investors, as a group and pro rata in accordance with their respective membership interests in Intrexon Energy Partners, have committed to make additional capital contributions of up to $25,000 , at the request of Intrexon Energy Partners' board of managers (the "Intrexon Energy Partners Board") and subject to certain limitations. As of December 31, 2017 , the Company's remaining commitment was $6,011 . Intrexon Energy Partners is governed by the Intrexon Energy Partners Board which has five members. Two members of the Intrexon Energy Partners Board are designated by the Company and three members are designated by a majority of the IEP Investors. The Company and the IEP Investors have the right, but not the obligation, to make additional capital contributions above the initial limits when and if solicited by the Intrexon Energy Partners Board. The Company's investment in Intrexon Energy Partners was $(444) and $(477) as of December 31, 2017 and 2016 , respectively, and is included in other accrued liabilities in the accompanying consolidated balance sheets. Intrexon Energy Partners II In December 2015, the Company and certain investors (the "IEPII Investors"), including Harvest, entered into a Limited Liability Company Agreement which governs the affairs and conduct of business of Intrexon Energy Partners II, LLC ("Intrexon Energy Partners II"), a joint venture formed to utilize the Company's MBP technology for the production of 1,4-butanediol, an industrial chemical used to manufacture spandex, polyurethane, plastics, and polyester. The Company also entered into an ECC with Intrexon Energy Partners II which provides exclusive rights to the Company's technology for use in the field, as a result of which the Company received a technology access fee of $18,000 while retaining a 50% membership interest in Intrexon Energy Partners II. The IEPII Investors made initial capital contributions, totaling $18,000 in the aggregate, in exchange for pro rata membership interests in Intrexon Energy Partners II totaling 50% . In December 2015, the owners of Intrexon Energy Partners II made a capital contribution of $4,000 , half of which was paid by the Company. Intrexon has committed to make additional capital contributions of up to $10,000 , and the IEPII Investors, as a group and pro rata in accordance with their respective membership interests in Intrexon Energy Partners II, have committed to make additional capital contributions of up to $10,000 , at the request of Intrexon Energy Partners II's board of managers (the "Intrexon Energy Partners II Board") and subject to certain limitations. Intrexon Energy Partners II is governed by the Intrexon Energy Partners II Board which has five members. One member of the Intrexon Energy Partners II Board is designated by the Company and four members are designated by a majority of the IEPII Investors. The Company and the IEPII Investors have the right, but not the obligation, to make additional capital contributions above the initial limits when and if solicited by the Intrexon Energy Partners II Board. The Company's investment in Intrexon Energy Partners II was $572 and $1,414 as of December 31, 2017 and 2016 , respectively, and is included in investments in affiliates in the accompanying consolidated balance sheets. EnviroFlight In February 2016, the Company entered into a series of transactions involving EnviroFlight, LLC ("Old EnviroFlight"), Darling Ingredients Inc. ("Darling") and a newly formed venture between the Company and Darling ("New EnviroFlight"). The Company determined that the series of integrated transactions to acquire substantially all of the assets of Old EnviroFlight for cash, common stock, and contingent consideration should be accounted for as a single transaction, which constituted a business, and considered New EnviroFlight to be the accounting acquirer. Consideration paid to Old EnviroFlight was $4,244 in cash, 136,340 shares of the Company's common stock valued at $4,401 and contingent consideration estimated at $3,660 . Contemporaneously, all the assets acquired from Old EnviroFlight, with the exception of certain developed technology, and $3,000 of cash were contributed to New EnviroFlight in exchange for a non-controlling, 50% membership interest in New EnviroFlight. The Company's contributions to New EnviroFlight included an exclusive license to the developed technology that was retained by the Company. Darling received the remaining 50% membership interest in New EnviroFlight as consideration for terminating rights previously held in the developed technology with Old EnviroFlight. New EnviroFlight was formed to generate high-nutrition, low environmental impact animal and fish feed, as well as fertilizer products, from black soldier fly larvae. The Company and Darling as members have each agreed to make additional capital contributions of up to $5,000 to fund ongoing operations of New EnviroFlight. As of December 31, 2017 , the Company's remaining commitment was $250 , which was satisfied in January 2018. All of the employees of Old EnviroFlight became employees of New EnviroFlight. The Company determined that its investment in New EnviroFlight should be accounted for using the equity method of accounting. The Company recorded an estimated fair value of $5,425 for its investment in New EnviroFlight and $9,880 for the retained developed technology intangible asset. The developed technology is being amortized over a period of twenty-one years . The contingent consideration liability payable to the members of Old EnviroFlight is considered a freestanding financial instrument and is recorded at fair value each reporting period. New EnviroFlight met a regulatory milestone, as defined in the asset purchase agreement, and the members of Old EnviroFlight received a portion of the contingent consideration consisting of 59,337 shares of the Company's common stock valued at $1,583 in October 2016. The members of Old EnviroFlight may receive up to $4,000 of additional shares of the Company's common stock if certain commercial milestones are met prior to February 2019. Based upon management's assessment of the likelihood of New EnviroFlight achieving the commercial milestones, the Company wrote-off the remaining balance of its estimated liability during the year ended December 31, 2017 (Note 8 ). The Company's investment in New EnviroFlight was $7,092 and $4,189 as of December 31, 2017 and 2016 , respectively, and is included in investments in affiliates in the accompanying consolidated balance sheets. Intrexon T1D Partners In March 2016, the Company and certain investors (the "T1D Investors"), including affiliates of Third Security, entered into a Limited Liability Company Agreement which governs the affairs and conduct of business of Intrexon T1D Partners, LLC ("Intrexon T1D Partners"), a joint venture formed to utilize the Company's proprietary ActoBiotics platform to develop and commercialize products to treat type 1 diabetes. The Company also entered into an ECC with Intrexon T1D Partners which provides the exclusive rights to the Company's technology for use in the field, as a result of which the Company received a technology access fee of $10,000 while retaining a 50% membership interest in Intrexon T1D Partners. The T1D Investors made initial capital contributions, totaling $10,000 in the aggregate, in exchange for pro rata membership interests in Intrexon T1D Partners totaling 50% . Intrexon has committed to make capital contributions of up to $5,000 , and the T1D Investors, as a group and pro rata in accordance with their respective membership interests in Intrexon T1D Partners, have committed to make additional capital contributions of up to $5,000 , at the request of Intrexon T1D Partners' board of managers (the "Intrexon T1D Partners Board") and subject to certain limitations. As of December 31, 2017 , the Company's remaining commitment was $2,900 . Intrexon T1D Partners is governed by the Intrexon T1D Partners Board, which has five members. Two members of the Intrexon T1D Partners Board are designated by the Company and three members are designated by a majority of the T1D Investors. The Company and the T1D Investors have the right, but not the obligation, to make additional capital contributions above these limits when and if solicited by the Intrexon T1D Partners Board. The Company's investment in Intrexon T1D Partners was $(943) and $806 as of December 31, 2017 and 2016 , respectively, and is included in other accrued liabilities and investments in affiliates, respectively, in the accompanying consolidated balance sheets. |
Collaboration and Licensing Rev
Collaboration and Licensing Revenue | 12 Months Ended |
Dec. 31, 2017 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
Collaboration and Licensing Revenue | Collaboration and Licensing Revenue The Company's collaborations and licensing agreements provide for multiple deliverables to be delivered by the Company and typically include a license to the Company's technology platforms, participation in collaboration committees, performance of certain research and development services and may include obligations for certain manufacturing services. The Company typically groups these deliverables into two units of accounting based on the nature of the deliverables and the separation criteria. The first deliverable ("Unit of Accounting 1") includes the license to the Company's technology platform, the Company's participation on the collaboration committees and any research and development services associated with its technology platforms. The deliverables for Unit of Accounting 1 are combined because they cannot be individually separated. If applicable, the second deliverable ("Unit of Accounting 2") includes manufacturing services to be provided for any Company materials in an approved product. These services have standalone value and are contingent due to uncertainties on whether an approved product will ever be developed thereby requiring manufacture by the Company at that time. All upfront consideration is allocated to Unit of Accounting 1. Unit of Accounting 2 is determined to be a contingent deliverable at the inception of the collaboration due to the uncertainties surrounding whether an approved product will ever be developed and require manufacturing by the Company. The upfront consideration allocated to Unit of Accounting 1 is recognized over the expected life of the Company's technology platform using a straight-line approach which approximates the period the Company expects to complete its performance obligations. The Company recognizes the reimbursement payments received for research and development services in the period when the services are performed and collection is reasonably assured. At the inception of each collaboration, the Company determines whether any milestone payments are substantive and can be recognized when earned. The milestone payments are typically not considered substantive. Royalties related to product sales will be recognized when earned since payments relate directly to products that have been fully developed and for which the Company has satisfied all of its obligations. The Company determines whether collaborations and licensing agreements are individually significant for disclosure based on a number of factors, including total revenue recorded by the Company pursuant to collaboration and licensing agreements, collaborators or licensees with either majority-owned subsidiaries or equity method investments, or other qualitative factors. Collaboration and licensing revenues generated from consolidated subsidiaries are eliminated in consolidation. The following tables summarize the amounts recorded as revenue in the consolidated statements of operations for each significant collaboration or licensing agreement for the years ended December 31, 2017 , 2016 and 2015 . Year Ended December 31, 2017 Revenue Recognized From Total Upfront and Milestone Payments Research and Development Services ZIOPHARM Oncology, Inc. $ 48,313 $ 21,499 $ 69,812 Oragenics, Inc. 1,047 973 2,020 Fibrocell Science, Inc. 2,419 4,925 7,344 Genopaver, LLC 273 6,417 6,690 S & I Ophthalmic, LLC — 755 755 OvaXon, LLC — 1,966 1,966 Intrexon Energy Partners, LLC 2,500 8,165 10,665 Persea Bio, LLC 500 446 946 Ares Trading S.A. 6,389 4,349 10,738 Intrexon Energy Partners II, LLC 2,000 1,672 3,672 Intrexon T1D Partners, LLC 1,109 4,859 5,968 Harvest start-up entities (1) 2,442 12,790 15,232 Other 4,645 5,126 9,771 Total $ 71,637 $ 73,942 $ 145,579 (1) For the year ended December 31, 2017 , revenue recognized from collaborations with Harvest start-up entities include Thrive Agrobiotics, Inc.; Exotech Bio, Inc.; Relieve Genetics, Inc.; AD Skincare, Inc.; Genten Therapeutics, Inc.; and CRS Bio, Inc. Year Ended December 31, 2016 Revenue Recognized From Total Upfront and Milestone Payments Research and Development Services ZIOPHARM Oncology, Inc. $ 11,529 $ 22,307 $ 33,836 Oragenics, Inc. 1,047 1,705 2,752 Fibrocell Science, Inc. 2,419 3,523 5,942 Genopaver, LLC 273 5,844 6,117 S & I Ophthalmic, LLC — 6,141 6,141 OvaXon, LLC — 2,934 2,934 Intrexon Energy Partners, LLC 2,500 15,052 17,552 Persea Bio, LLC 500 778 1,278 Ares Trading S.A. 6,389 3,803 10,192 Intrexon Energy Partners II, LLC 2,000 1,169 3,169 Intrexon T1D Partners, LLC 821 1,087 1,908 Harvest start-up entities (1) 1,383 3,591 4,974 Other 5,572 7,504 13,076 Total $ 34,433 $ 75,438 $ 109,871 (1) For the year ended December 31, 2016 , revenue recognized from collaborations with Harvest start-up entities include Thrive Agrobiotics, Inc.; Exotech Bio, Inc.; Relieve Genetics, Inc.; AD Skincare, Inc.; Genten Therapeutics, Inc.; and CRS Bio, Inc. Year Ended December 31, 2015 Revenue Recognized From Total Upfront and Milestone Payments Research and Development Services ZIOPHARM Oncology, Inc. $ 2,855 $ 16,451 $ 19,306 Oragenics, Inc. 5,679 856 6,535 Fibrocell Science, Inc. 6,046 6,133 12,179 Genopaver, LLC 273 3,556 3,829 S & I Ophthalmic, LLC — 4,115 4,115 OvaXon, LLC — 2,540 2,540 Intrexon Energy Partners, LLC 2,500 10,947 13,447 Persea Bio, LLC 500 741 1,241 Ares Trading S.A. 3,933 795 4,728 Intrexon Energy Partners II, LLC 167 — 167 Harvest start-up entities (1) 46 220 266 Other 10,514 8,954 19,468 Total $ 32,513 $ 55,308 $ 87,821 (1) For the year ended December 31, 2015 , revenue recognized from collaborations with Harvest start-up entities include Thrive Agrobiotics, Inc. The following is a summary of the terms of the Company's significant collaborations and licensing agreements. ZIOPHARM Collaborations In January 2011, the Company entered into an ECC with ZIOPHARM, a related party. Pursuant to the ECC, ZIOPHARM received a license to the Company's technology platform within the field of oncology as defined more specifically in the agreement. Upon execution of the ECC, the Company received 3,636,926 shares of ZIOPHARM's common stock valued at $17,457 as upfront consideration. In addition to the deliverables discussed above, the Company transferred two clinical product candidates to ZIOPHARM that resulted in a separate unit of accounting for which $1,115 of the upfront consideration was allocated and recognized as collaboration revenue in 2011. The remaining $16,342 of upfront consideration was allocated to Unit of Accounting 1 discussed above. The Company was entitled to additional shares of common stock representing the lesser of (i) the original shares received or (ii) the number of shares representing 7.495% of ZIOPHARM's outstanding shares at the date of the dosing of the first patient in a Phase II clinical trial of a product candidate created, produced or developed by ZIOPHARM using the Company's technology ("ZIOPHARM Milestone"). In October 2012, the ZIOPHARM Milestone was achieved and the Company received 3,636,926 shares of ZIOPHARM's common stock valued at $18,330 as milestone consideration. Since the ZIOPHARM Milestone was not substantive, the Company allocated the ZIOPHARM Milestone to the applicable units of accounting and is recognizing it in a manner similar to these units of accounting. The Company receives reimbursement payments for research and development services provided and manufacturing services for Company materials provided to ZIOPHARM during the ECC. Subject to certain expense allocations, ZIOPHARM will pay the Company a percentage of the quarterly net profits derived from the sale of products developed from the ECC, as defined and amended in the agreement. ZIOPHARM is responsible for conducting preclinical and clinical development of product candidates, as well as for other aspects of commercialization or manufacturing of product candidates. The term of the ECC commenced in January 2011 and continues until terminated pursuant to the ECC agreement. The ECC may be terminated by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by ZIOPHARM upon 90 days written notice to the Company. In March 2015, in conjunction with the worldwide License and Collaboration Agreement ("Merck Agreement") with Ares Trading, a subsidiary of the biopharmaceutical business of Merck KGaA, and ZIOPHARM discussed below, the Company and ZIOPHARM amended their existing ECC. The amendment modifies the scope of the ECC in connection with the Merck Agreement and provides that the Company will pay to ZIOPHARM 50% of all payments received for upfront fees, milestones and royalties under the Merck Agreement. In September 2015, the Company entered into its second ECC with ZIOPHARM ("ZIOPHARM ECC 2"). Pursuant to the ECC, ZIOPHARM received a license to the Company's technology platform to develop and commercialize novel biotherapeutics for the treatment of patients with graft-versus-host disease, or GvHD. Upon execution of ZIOPHARM ECC 2, the Company received a technology access fee of $10,000 . The Company received reimbursement payments for research and development services provided pursuant to the agreement during the ECC and manufacturing services for Company materials provided to ZIOPHARM during the ECC. In December 2017, the Company and ZIOPHARM mutually agreed to terminate ZIOPHARM ECC2 and accordingly, the Company recognized the remaining balance of the deferred revenue associated with ZIOPHARM ECC2 totaling $28,943 . In June 2016, the Company amended each of its two existing collaboration agreements with ZIOPHARM and as a result the rate of the royalty which the Company is entitled to receive on certain products commercialized pursuant to the agreements was reduced from 50% to 20% . As consideration for execution of the amendments, ZIOPHARM issued the Company 100,000 shares of ZIOPHARM's Series 1 Preferred Stock valued at $120,000 . The Company allocated the consideration received to each ECC based on the cumulative value of upfront and milestone payments previously received pursuant to that ECC. Because the Company has remaining performance obligations under each of the ZIOPHARM ECCs, the Company recorded the initial fair value received as deferred revenue and recognizes this amount straight-line over the remaining performance period for each ZIOPHARM ECC. No other financially significant terms of the ZIOPHARM ECCs were changed as a result of the amendments. See Note 7 for additional discussion of the terms of the preferred stock and the accounting treatment. Oragenics Collaborations In June 2012, the Company entered into an ECC with Oragenics, a publicly traded company focused on becoming the world leader in novel antibiotics against infectious diseases and a related party. Pursuant to the ECC, at the transaction effective date, Oragenics received a license to the Company's technology platform within the field of lantibiotics for the treatment of infectious diseases in humans and companion animals as defined more specifically in the agreement. Upon execution of the ECC, the Company received a technology access fee of 439,243 shares of Oragenics' common stock valued at $6,588 as upfront consideration. In November 2017, the Company amended the ECC agreement with Oragenics, and as a result, the Company is entitled to up to $35,000 of potential one-time payments for certain regulatory milestones. The Company receives reimbursement payments for research and development services provided pursuant to the agreement during the ECC and manufacturing services for Company materials provided to Oragenics during the ECC. Oragenics will pay the Company 25% of the quarterly profits derived from the sale of products developed from the ECC, as defined in the agreement. Oragenics is responsible for funding the further development of lantibiotics toward the goal of commercialization, conducting preclinical and clinical development of product candidates, as well as for other aspects of commercialization or manufacturing of the product candidates. The term of the ECC commenced in June 2012 and continues until terminated pursuant to the ECC agreement. The ECC may be terminated by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by Oragenics upon 90 days written notice to the Company. In September 2013, the Company entered into its second ECC with Oragenics ("Oragenics ECC 2"). Pursuant to Oragenics ECC 2, at the transaction effective date, Oragenics received a license to the Company's technology platform to develop and commercialize probiotics, specifically the direct administration to humans of genetically modified probiotics for the treatment of diseases of the oral cavity, throat, sinus and esophagus as defined more specifically in the agreement. Upon execution of Oragenics ECC 2, the Company received a technology access fee of 134,800 shares of Oragenics' common stock valued at $3,503 and a $1,956 convertible promissory note maturing on or before December 31, 2013 as upfront consideration. Prior to the maturity date, Oragenics had the right to convert the promissory note into shares of Oragenics' common stock subject to its shareholders' approval. The conversion price was equal to the closing price of Oragenics' common stock on the last trading day immediately prior to the date of conversion. In December 2013, Oragenics converted the promissory note into 69,824 shares of Oragenics' common stock. In September 2015, Oragenics and the Company mutually agreed to terminate Oragenics ECC 2 and accordingly, the Company recognized the remaining balance of the deferred revenue associated with the upfront payment. In June 2015, the Company entered into its third ECC with Oragenics ("Oragenics ECC 3"). Pursuant to Oragenics ECC 3, at the transaction effective date, Oragenics received a license to the Company's technology platform within the field of biotherapeutics for use in certain treatments of oral mucositis and other diseases and conditions of the oral cavity, throat, and esophagus. Upon execution of Oragenics ECC 3, the Company received a technology access fee of a $5,000 convertible promissory note maturing on or before December 31, 2015 as upfront consideration. Prior to the maturity date, Oragenics had the right to convert the promissory note into shares of Oragenics' common stock, subject to its shareholders' approval. In December 2015, Oragenics converted the promissory note into 338,100 shares of Oragenics' common stock. The Company is also entitled to up to $22,000 of potential payments for development and commercial milestones for each Oragenics product developed from Oragenics ECC 3 and up to $10,000 of potential one-time payments for certain regulatory milestones under Oragenics ECC 3. The Company receives reimbursement payments for research and development services provided pursuant to the agreement during the ECC and manufacturing services for Company materials provided to Oragenics during Oragenics ECC 3. Oragenics will pay the Company royalties as a percentage in the low-teens of net sales derived from the sale of products developed from Oragenics ECC 3, as defined in the agreement. In November 2017, the Company amended the Oragenics ECC 3 agreement, and as a result, the Company is entitled to an additional $5,500 of potential payments for development and commercial milestones for each Oragenics product developed from Oragenics ECC 3. Oragenics is responsible for funding the further development of Oragenics ECC 3 products towards the goal of commercialization, conducting preclinical and clinical development of product candidates, as well as for other aspects of commercialization or manufacturing of the product candidates. The term of Oragenics ECC 3 commenced in June 2015 and may be terminated by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by Oragenics upon 90 days written notice to the Company. All Oragenics share data noted above reflect a 1-for-10 reverse stock split of Oragenics' common stock effective January 19, 2018. Fibrocell Science Collaborations In October 2012, the Company entered into an ECC ("Fibrocell ECC 1") with Fibrocell Science, Inc. ("Fibrocell"), a publicly traded cell and gene therapy company focused on diseases affecting the skin and connective tissue and a related party. Pursuant to the ECC, at the transaction effective date, Fibrocell received a license to the Company's technology platform to develop and commercialize genetically modified and non-genetically modified autologous fibroblasts and autologous dermal cells in the United States of America. Upon execution of the ECC, the Company received a technology access fee of 439,173 shares of Fibrocell's common stock valued at $7,576 as upfront consideration. The Company receives reimbursement payments for research and development services provided pursuant to the agreement during the ECC and manufacturing services for Company materials provided to Fibrocell during the ECC. On a quarterly basis, Fibrocell will pay the Company royalties of 7% of net sales up to $25,000 and 14% of net sales above $25,000 on each product developed from the ECC, as defined in the agreement. If Fibrocell uses the Company's technology platform to improve the production of a current or new Fibrocell product not developed from the ECC, Fibrocell will pay the Company quarterly royalties equal to 33% of the cost of goods sold savings generated by the improvement, as defined in the agreement. Fibrocell is responsible for conducting preclinical and clinical development of product candidates associated with Fibrocell ECC 1, as well as for other aspects of commercialization and manufacturing of the product candidates. The term of the ECC commenced in October 2012 and continues until terminated pursuant to the ECC agreement. The ECC may be terminated by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by Fibrocell upon 90 days written notice to the Company. In June 2013, the Company and Fibrocell entered into an amendment to the Fibrocell ECC 1. The amendment expanded the field of use defined in the ECC agreement. Under the terms of the amendment to the Fibrocell ECC 1, the Company received 414,594 shares of Fibrocell's common stock valued at $7,612 as a supplemental technology access fee. The Company allocated this additional consideration to the appropriate unit of accounting and is recognizing it consistent with the unit of accounting. In January 2014, the Company and Fibrocell entered into a second amendment to the Fibrocell ECC 1. The second amendment further expanded the field of use defined in the ECC agreement. Under the terms of the second amendment to the Fibrocell ECC 1, the Company received 341,530 shares of Fibrocell's common stock valued at $5,225 as a supplemental technology access fee. The Company allocated this additional consideration to the appropriate unit of accounting. In September 2015, Fibrocell and the Company mutually agreed to terminate the second amendment to the ECC and accordingly, the Company recognized the remaining balance of deferred revenue associated with the related upfront payment. In December 2015, the Company entered into a second ECC with Fibrocell ("Fibrocell ECC 2"). Pursuant to the ECC, at the transaction effective date, Fibrocell received a license to the Company's technology platform to develop and commercialize genetically-modified fibroblasts to treat chronic inflammatory and degenerative diseases of the joint, including arthritis and related conditions. Upon execution of the ECC, the Company received a technology access fee of $10,000 . The Company is also entitled to (i) up to $30,000 of potential one-time payments for certain development and regulatory milestones for the first product developed under Fibrocell ECC 2, (ii) up to $30,000 of potential payments for certain regulatory milestones for each additional product developed under Fibrocell ECC 2, and (iii) up to $22,500 of potential payments for certain sales milestones for each product developed under Fibrocell ECC 2. The Company receives reimbursement payments for research and development services provided pursuant to the agreement during the ECC and manufacturing services for Company materials provided to Fibrocell during the ECC. Fibrocell will pay the Company royalties as a percentage in the low double-digits of net sales derived from the sale of products developed from Fibrocell ECC 2, as defined in the agreement. Fibrocell is responsible for conducting preclinical and clinical development of product candidates associated with Fibrocell ECC 2, as well as for other aspects of commercialization and manufacturing of the product candidates. The term of the ECC commenced in December 2015 and continues until terminated pursuant to the ECC agreement. The ECC may be terminated by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by Fibrocell upon 90 days written notice to the Company. All Fibrocell share data noted above reflect a 1-for-3 reverse stock split of Fibrocell's common stock effective March 10, 2017. Genopaver Collaboration In March 2013, the Company entered into an ECC with Genopaver, LLC ("Genopaver"), an affiliate of Third Security and a related party. Genopaver was formed for the purpose of entering into the ECC and developing and commercializing products in the field of the fermentative production of alkaloids through genetically modified cell-lines and substrate feeds for use as active pharmaceutical ingredients or as commercially sold intermediates in the manufacture of active pharmaceutical ingredients. Upon execution of the ECC, the Company received a technology access fee of $3,000 as upfront consideration. The Company receives reimbursement payments for research and development services provided pursuant to the agreement during the ECC. Genopaver will pay the Company royalties as a percentage in the lower-double digits on the quarterly gross profits of product sales from products developed under the ECC, as defined in the agreement. Genopaver is responsible for the development and commercialization of the product candidates. The term of the ECC commenced in March 2013 and continues until terminated pursuant to the ECC agreement. The ECC may be terminated by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by Genopaver upon 90 days written notice to the Company. AquaBounty Collaboration In February 2013, the Company entered into an ECC with AquaBounty, a majority-owned consolidated subsidiary. The Company will be reimbursed for research and development services as provided for in the ECC agreement. In the event of product sales from a product developed from the ECC, the Company will receive 16.66% of quarterly gross profits for each product, as defined in the agreement. All revenues and expenses related to this ECC are eliminated in consolidation. S & I Ophthalmic Collaboration In September 2013, the Company entered into an ECC with S & I Ophthalmic, a joint venture between the Company and Sun Pharmaceutical Subsidiary, an indirect subsidiary of Sun Pharmaceutical, an international specialty pharmaceutical company focused on chronic diseases, and a related party. The ECC granted S & I Ophthalmic an exclusive license to the Company's technology platform to develop and commercialize therapies in humans for the treatment of ocular diseases defined more specifically in the agreement. The Company was reimbursed for research and development services pursuant to the agreement and manufacturing services for Company materials provided to S & I Ophthalmic during the ECC. The term of the ECC commenced in September 2013. In December 2017, the Company and Sun Pharmaceutical Subsidiary mutually agreed to terminate the ECC and dissolve the joint venture. OvaXon Collaboration In December 2013, the Company entered into an ECC with OvaXon, a joint venture between the Company and OvaScience, a life sciences company focused on infertility treatments, and a related party. The ECC grants OvaXon an exclusive license to the Company's technology platform to create new applications for improving human and animal health. OvaScience also licensed certain technology to OvaXon pursuant to a separate license agreement. The Company will be reimbursed for research and development services and manufacturing services as provided for in the ECC agreement. The term of the ECC commenced in December 2013 and continues until terminated by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by OvaXon upon 90 days written notice to the Company. See additional discussion in Note 22 . Intrexon Energy Partners Collaboration In March 2014, the Company entered into an ECC with Intrexon Energy Partners, a joint venture between the Company and certain investors and a related party. The ECC grants Intrexon Energy Partners an exclusive license to the Company's technology platform to optimize and scale-up the Company's methane bioconversion platform for the production of certain fuels and lubricants. Upon execution of the ECC, the Company received a technology access fee of $25,000 as upfront consideration. The Company will be reimbursed for research and development services as provided for in the ECC agreement. The term of the ECC commenced in March 2014 and continues until March 2034 unless terminated prior to that date by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by Intrexon Energy Partners upon 90 days written notice to the Company. Persea Bio Collaboration In December 2014, the Company entered into an ECC with Persea Bio, LLC ("Persea Bio"), an affiliate of Third Security and a related party. Persea Bio was formed for the purpose of entering into the ECC and developing and commercializing a food program, as defined in the agreement. Upon effectiveness of the ECC, the Company received a technology access fee of $5,000 as upfront consideration. The Company receives reimbursement payments for research and development services provided pursuant to the agreement during the ECC. Persea Bio will pay the Company royalties as a percentage in the lower-double digits on the quarterly gross profits of product sales from products derived from the ECC, as defined in the agreement. Persea Bio is responsible for the development and commercialization of the product candidates. The term of the ECC commenced in December 2014 and continues until terminated by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by Persea Bio upon 90 days written notice to the Company. Merck Licensing Agreement In March 2015, the Company signed the Merck Agreement with Ares Trading and ZIOPHARM through which the parties established a collaboration for the research and development and commercialization of certain products for the prophylactic, therapeutic, palliative or diagnostic use for cancer in humans. Pursuant to the Merck Agreement, the Company received a technology access fee of $115,000 as upfront consideration, of which $57,500 was paid to ZIOPHARM in accordance with the terms of the agreement. Upon the selection of the first two targets by Ares Trading, the Company received $10,000 in equal quarterly installments over two years. The Company is entitled to receive a further $5,000 for each additional target selected by Ares Trading. The Company is also entitled to up to $413,000 of potential payments for substantive and non-substantive development and commercial milestones for each product, and royalties ranging from the lower-single digits to the low-teens of the net sales derived from the sale of products developed under the Merck Agreement. The Company may also receive up to $50,000 of further cash fees upon certain technical milestones as provided for in the agreement. The term of the Merck Agreement commenced in May 2015 and may be terminated by either party in the event of a material breach as defined in the agreement and may be terminated voluntarily by Ares Trading upon 90 days written notice to the Company. The Company will pay to ZIOPHARM 50% of all payments received for upfront fees, milestones, and royalties under the Merck Agreement. Thrive Agrobiotics Collaboration In September 2015, the Company entered into an ECC with Thrive Agrobiotics, Inc. ("Thrive Agrobiotics"), an affiliate of Harvest and a related party. Thrive Agrobiotics was formed for the purpose of entering into the ECC and developing and commercializing products to improve the overall growth and feed efficiency in piglets. Upon execution of the ECC, the Company received a technology access fee in the form of equity in Thrive Agrobiotics valued at $1,667 as upfront consideration. The Company is also entitled to up to $5,500 of potential payments for development and commercial milestones for each product developed under the ECC. The Company receives reimbursement payments for research and development services provided pursuant to the agreement during the ECC. Thrive Agrobiotics will pay the Company royalties as a percentage in the lower-double digits on the quarterly gross profits of product sales from products developed under the ECC, as defined in the agreement. Thrive Agrobiotics is responsible for the development and commercialization of the product candidates. The term of the ECC commenced in September 2015 and continues until terminated pursuant to the ECC agreement. The ECC may be terminated by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by Thrive Agrobiotics upon 90 days written notice to the Company. Intrexon Energy Partners II Collaboration In December 2015, the Company entered into an ECC with Intrexon Energy Partners II, a joint venture between the Company and certain investors and a related party. Pursuant to the ECC, Intrexon Energy Partners II received an exclusive license to the Company's technology platform to optimize and scale-up the Company's methane bioconversion platform for the production of 1,4-butanediol (BDO), a key chemical intermediate that is used to manufacture spandex, polyurethane, plastics, and polyester. Upon execution of the ECC, the Company received a technology access fee of $18,000 and is entitled to reimbursement of research and development services as provided for in the ECC agreement. The term of the ECC commenced in December 2015 and continues until December 2035; termination prior to that date may be initiated (i) by either party in the event of certain material breaches defined in the agreement or (ii) may be terminated voluntarily by Intrexon Energy Partners II upon 90 days written notice to the Company. Exotech Bio Collaboration In March 2016, the Company entered into an ECC with Exotech Bio, Inc. ("Exotech Bio"), an affiliate of Harvest and a related party. Exotech Bio was formed for the purpose of entering into the ECC and developing and commercializing products using exosomes carrying a RNA payload designed to kill, suppress, or render immune-visible a cancer cell. Upon execution of the ECC, the Company received a technology access fee in the form of equity in Exotech Bio valued at $5,000 as upfront consideration. The Company is also entitled to up to $52,500 of potential payments for substantive and non-substantive development and commercial milestones for each product developed under the ECC. The Company receives reimbursement payments for research and development services provided pursuant to the ECC. Exotech Bio will pay the Company royalties as a percentage in the lower double-digits on the quarterly net sales of products developed under the ECC, as defined in the agreement. Exotech Bio is responsible for the development and commercialization of the product candidates. The term of the ECC commenced in March 2016 and continues until terminated pursuant to the ECC agreement. The ECC may be terminated by either party in the event of certain material breaches defined in the agreement and may be terminated voluntarily by Exotech Bio upon 90 days written notice to the Company. Relieve Genetics Collaboration In March 2016, the Company entered into an ECC with Relieve Genetics, Inc. ("Relieve Genetics"), an affiliate of Harvest and a related party. Relieve Genetics was formed for the purpose of entering |
Short-term and Long-term Invest
Short-term and Long-term Investments | 12 Months Ended |
Dec. 31, 2017 | |
Investments, Debt and Equity Securities [Abstract] | |
Short-term and Long-term Investments | Short-term and Long-term Investments The Company's investments are classified as available-for-sale. The following table summarizes the amortized cost, gross unrealized gains and losses and fair value of available-for-sale investments as of December 31, 2017 : Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Aggregate Fair Value U.S. government debt securities $ 6,000 $ — $ (2 ) $ 5,998 Certificates of deposit 275 — — 275 Total $ 6,275 $ — $ (2 ) $ 6,273 The following table summarizes the amortized cost, gross unrealized gains and losses and fair value of available-for-sale investments as of December 31, 2016 : Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Aggregate Fair Value U.S. government debt securities $ 180,412 $ 5 $ (94 ) $ 180,323 Certificates of deposit 272 — — 272 Total $ 180,684 $ 5 $ (94 ) $ 180,595 For more information on the Company's method for determining the fair value of its assets, see Note 2 – "Fair Value of Financial Instruments". As of December 31, 2017 , all of the available-for-sale investments were due within one year based on their contractual maturities. Changes in market interest rates and bond yields cause certain investments to fall below their cost basis, resulting in unrealized losses on investments. The unrealized losses of the Company's investments were primarily a result of unfavorable changes in interest rates subsequent to the initial purchase of these investments and are not significant as of December 31, 2017 . As of December 31, 2017 and 2016 , the Company did not consider any of its investments to be other-than-temporarily impaired. When evaluating its investments for other-than-temporary impairment, the Company reviews factors such as the length of time and extent to which fair value has been below its cost basis, the financial condition of the issuer, the Company's ability and intent to hold the security and whether it is more likely than not that it will be required to sell the investment before recovery of its cost basis. |
Investments in Preferred Stock
Investments in Preferred Stock | 12 Months Ended |
Dec. 31, 2017 | |
Investment in Preferred Stock [Abstract] | |
Investments In Preferred Stock | Investments in Preferred Stock Investment in ZIOPHARM Preferred Stock In June 2016, the Company received 100,000 shares of Series 1 Preferred Stock (the "Preferred Shares") of ZIOPHARM with a per share stated value of $1,200 , as consideration for amending their two previously existing ECC agreements (Note 5 ). A summary of the terms of the Preferred Shares follows. Conversion. The Preferred Shares shall automatically convert into shares of ZIOPHARM common stock upon the date the first approval in the United States of (i) a ZIOPHARM product, as defined in and developed under one of the ECC agreements, or (ii) a product, as defined and developed under the License and Collaboration Agreement with Ares Trading and ZIOPHARM, is publicly announced (the "Conversion Event Date"). The Preferred Shares shall convert into a number of shares of ZIOPHARM common stock equal to the stated value of such Preferred Share, divided by the greater of: (i) the volume weighted average closing price of ZIOPHARM's common stock over the twenty trading days ending on the Conversion Event Date or (ii) $1.00 . The number of converted shares is subject to certain limitations defined in the amended and restated Certificate of Designation, Preferences, and Rights of Series 1 Preferred Stock (the "A&R Certificate of Designation"). Dividend Rights. The Company shall receive a monthly dividend, payable in additional Preferred Shares, equal to $12.00 per Preferred Share held per month divided by the stated value of the Preferred Shares, which is referred to as the PIK Dividend. For any Preferred Shares that are not converted on the Conversion Event Date, the rate of PIK Dividend on these unconverted Preferred Shares will automatically increase from $12.00 to $24.00 per Preferred Share per month. Voting Rights . The Preferred Shares do not have any voting rights except for certain protective voting rights defined in the A&R Certificate of Designation. Liquidation Rights. In the event of any voluntary or involuntary liquidation, dissolution or winding up of ZIOPHARM or a deemed liquidation event, as defined in the A&R Certificate of Designation, including a change of control or the sale, lease transfer, or exclusive license of all or substantially all of ZIOPHARM's assets, the holders of the Preferred Shares shall be entitled to receive a portion of all funds to be distributed in proportion to the holders' proportionate share of ZIOPHARM's common stock on an as-converted to common stock basis (the "Series 1 Liquidation Amount"). For purposes of calculating the Series 1 Liquidation Amount, if such liquidation event occurs prior to the Conversion Event Date, each Preferred Share shall be deemed to be convertible into the number of shares of ZIOPHARM's common stock equal to (i) the stated value of each Preferred Share, divided by (ii) the volume weighted average price of ZIOPHARM's common stock for the twenty day period ending on the date of the public announcement of the liquidation event. In addition, ZIOPHARM may elect to redeem the Preferred Shares in connection with or following a deemed liquidation event at a price per share equal to the Series 1 Liquidation Amount. The investment in ZIOPHARM preferred stock is categorized as Level 3 as there are significant unobservable inputs and the Preferred Shares are not traded on a public exchange. The fair value of the investment in ZIOPHARM preferred stock is estimated using a probability-weighted expected return ("PWERM") model. The key inputs used in the PWERM model are (i) estimating the future returns for conversion of the Preferred Shares for both product approval and a change in control of ZIOPHARM (the "conversion events") using market data of the change in value for guideline companies as a result of these conversion events; (ii) estimating the expected date and likelihood of each conversion event; and (iii) discounting these estimated future returns using a discount rate for the Preferred Shares considering industry debt issuances originated by public funds and venture capital rates of return. A significant change in unobservable inputs discussed above could result in a significant impact on the fair value of the Company's investment in ZIOPHARM preferred stock. The fair value of the Company's investment in ZIOPHARM preferred stock, including additional Preferred Shares received as dividends, was $160,832 and $129,545 as of December 31, 2017 and 2016 , respectively. During the years ended December 31, 2017 and 2016 , the Company received 13,460 shares and 6,184 shares, respectively, of additional Preferred Shares and recognized $16,717 and $7,421 , respectively, of dividend income in the accompanying consolidated statements of operations. Investment in Fibrocell Preferred Stock In March 2017, Fibrocell sold Series A Convertible Preferred Stock (the "Convertible Preferred Shares") convertible into shares of Fibrocell common stock and warrants to purchase shares of Fibrocell common stock to certain institutional and accredited investors, including the Company and affiliates of Third Security. The Company paid $1,161 in exchange for 1,161 Convertible Preferred Shares and warrants to acquire 498,843 shares of Fibrocell common stock, reflective of the 1-for-3 reverse stock split of Fibrocell's common stock effective March 10, 2017. The Convertible Preferred Shares are convertible at any time at the election of the Company and accrue dividends at 4% per annum, compounded quarterly, increasing the stated value of the shares. The investment in Fibrocell preferred stock is categorized as Level 3 as there are significant unobservable inputs and the Convertible Preferred Shares are not traded on a public exchange. The fair value of the investment in Fibrocell preferred stock is estimated using a conversion plus dividend approach utilizing the trading value of the underlying common stock and an estimated premium for the preferred stock dividend and other preferences. Market price volatility of Fibrocell's common stock and a significant change in the estimated preferred stock premium could result in a significant impact to the fair value of the investment in Fibrocell preferred stock. As of December 31, 2017 , the fair value of the Company's investment in Fibrocell preferred stock was $393 . See Note 18 for additional discussion of the warrants. Investment in Oragenics Preferred Stock In November 2017, concurrent with Oragenics closing a preferred stock private placement, the Company exchanged a promissory note, including accrued interest, purchased from Oragenics in May 2017 and receivables due from Oragenics totaling $3,385 for Oragenics Series C preferred stock ("Series C Preferred Stock"). The Series C Preferred Stock is non-voting and non-convertible and is redeemable in whole or part at any time by Oragenics in cash. The Series C Preferred Stock accrues an annual 12% dividend payable in additional Series C Preferred Stock through May 10, 2019, and after such date, the annual dividend increases to 20% . Additionally, the Company and Oragenics amended certain future payment terms under its ECCs (Note 5 ). As of December 31, 2017 , based on the most recent financial information available on Oragenics, the Company concluded that there was no value to its investment in Oragenics preferred stock. Changes in the Fair Value of Investments in Preferred Stock The following table summarizes the changes in the Level 3 investments in preferred stock during the years ended December 31, 2017 and 2016 . 2017 2016 Beginning balance $ 129,545 $ — Receipt of preferred stock as consideration for amendments to collaboration agreements — 120,000 Purchase of preferred stock 766 — Conversion of receivables to preferred stock 3,385 — Dividend income from investments in preferred stock 16,756 7,421 Net unrealized appreciation in the fair value of the investments in preferred stock 10,773 2,124 Ending balance $ 161,225 $ 129,545 |
Fair Value Measurements
Fair Value Measurements | 12 Months Ended |
Dec. 31, 2017 | |
Fair Value Disclosures [Abstract] | |
Fair Value Measurements | Fair Value Measurements The carrying amount of cash and cash equivalents, restricted cash, receivables, prepaid expenses and other current assets, accounts payable, accrued compensation and benefits, other accrued liabilities, and related party payables approximate fair value due to the short maturity of these instruments. The following table presents the placement in the fair value hierarchy of financial assets that are measured at fair value on a recurring basis, including the items for which the fair value option has been elected, as of December 31, 2017 : Quoted Prices in Active Markets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) December 31, Assets U.S. government debt securities $ — $ 5,998 $ — $ 5,998 Equity securities 10,537 4,563 — 15,100 Preferred stock — — 161,225 161,225 Other — 850 — 850 Total $ 10,537 $ 11,411 $ 161,225 $ 183,173 The following table presents the placement in the fair value hierarchy of financial assets that are measured at fair value on a recurring basis, including the items for which the fair value option has been elected, as of December 31, 2016 : Quoted Prices in Active Markets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) December 31, Assets U.S. government debt securities $ — $ 180,323 $ — $ 180,323 Equity securities 15,544 7,978 — 23,522 Preferred stock — — 129,545 129,545 Other — 1,917 — 1,917 Total $ 15,544 $ 190,218 $ 129,545 $ 335,307 The method used to estimate the fair value of the Level 1 assets in the tables above is based on observable market data as these equity securities are publicly-traded. The method used to estimate the fair value of the Level 2 short-term and long-term investments in the tables above is based on professional pricing sources for identical or comparable instruments, rather than direct observations of quoted prices in active markets. The method used to estimate the fair value of the Level 2 equity securities in the tables above is based on the quoted market price of the publicly-traded security, adjusted for a discount for lack of marketability. The methods used to estimate the fair value of the Level 3 assets are discussed in Note 7 . There were no transfers between levels of the fair value hierarchy during the year ended December 31, 2017 . The carrying values of the Company's long term debt approximates fair value due to the length of time to maturity and/or the existence of interest rates that approximate prevailing market rates. The Company's contingent consideration liabilities (Notes 3 and 4 ) are measured on a recurring basis and were $585 and $2,081 as of December 31, 2017 and 2016 , respectively. These fair value measurements were based on significant inputs not observable in the market and thus represented a Level 3 measurement. A significant change in unobservable inputs could result in a significant impact on the fair value of the Company's contingent consideration liabilities. The contingent consideration liabilities are remeasured to fair value at each reporting date until the contingency is resolved, and those changes in fair value are recognized in earnings. The changes in the fair value of the Level 3 liabilities during the years ended December 31, 2017 and 2016 were as follows: 2017 2016 Beginning balance $ 2,081 $ — Acquisition date fair value of contingent consideration liability 585 3,660 Payment of contingent consideration (Note 4) — (1,583 ) Change in fair value of contingent consideration recognized in selling, general and administrative expenses (2,081 ) 4 Ending balance $ 585 $ 2,081 |
Inventory
Inventory | 12 Months Ended |
Dec. 31, 2017 | |
Inventory Disclosure [Abstract] | |
Inventory | Inventory Inventory consists of the following: December 31, 2017 2016 Supplies, embryos and other production materials $ 2,673 $ 1,835 Work in process 4,767 5,466 Livestock 11,040 11,752 Feed 2,013 2,086 Total inventory $ 20,493 $ 21,139 |
Property, Plant and Equipment,
Property, Plant and Equipment, Net | 12 Months Ended |
Dec. 31, 2017 | |
Property, Plant and Equipment [Abstract] | |
Property, Plant and Equipment, Net | Property, Plant and Equipment, Net Property, plant and equipment consist of the following: December 31, 2017 2016 Land and land improvements $ 11,767 $ 10,904 Buildings and building improvements 18,183 8,123 Furniture and fixtures 2,515 2,176 Equipment 65,863 44,392 Leasehold improvements 25,277 15,105 Breeding stock 3,832 3,893 Computer hardware and software 10,128 6,844 Trees 6,642 2,772 Construction and other assets in progress 14,113 4,513 158,320 98,722 Less: Accumulated depreciation and amortization (45,646 ) (34,050 ) Property, plant and equipment, net $ 112,674 $ 64,672 Depreciation expense was $11,951 , $9,387 and $7,872 for the years ended December 31, 2017 , 2016 and 2015 , respectively. Included in the table above is $14,219 of land, buildings, and equipment related to a 2017 asset acquisition of a land-based aquaculture facility to be used in the production of AquAdvantage salmon in Indiana. |
Goodwill and Intangible Assets,
Goodwill and Intangible Assets, Net | 12 Months Ended |
Dec. 31, 2017 | |
Goodwill and Intangible Assets Disclosure [Abstract] | |
Goodwill and Intangible Assets, Net | Goodwill and Intangible Assets, Net The changes in the carrying amount of goodwill for the years ended December 31, 2017 and 2016 , are as follows: 2017 2016 Beginning balance $ 157,175 $ 165,169 Acquisitions 4,850 — Impairment (13,823 ) — Foreign currency translation adjustments 5,087 (7,994 ) Ending balance $ 153,289 $ 157,175 For the year ended December 31, 2017 , the Company recorded a $13,823 goodwill impairment charge, which primarily relates to AquaBounty. During the Company's annual goodwill impairment test, the Company determined, based on the price per share received by AquaBounty in its recent underwritten public offering (Note 22 ), it was more-likely-than-not that the fair value of the AquaBounty reporting unit was less than its carrying amount. As a result, the Company compared the carrying amount of the AquaBounty reporting unit to the fair value and determined the carrying amount exceeded the fair value resulting in a $13,001 goodwill impairment charge for the excess carrying value. The Company did not recognize any goodwill impairment charges during the years ended December 31, 2016 or 2015 , and there were no accumulated impairment charges as of December 31, 2016 . Intangible assets consist of the following as of December 31, 2017 : Weighted Average Useful Life (Years) Gross Carrying Amount Accumulated Amortization Net Patents, developed technologies and know-how 15.9 $ 263,615 $ (44,954 ) $ 218,661 Customer relationships 6.5 10,700 (6,383 ) 4,317 Trademarks 9.3 6,800 (2,567 ) 4,233 In-process research and development 5,666 — 5,666 Total $ 286,781 $ (53,904 ) $ 232,877 Intangible assets consist of the following as of December 31, 2016 : Gross Carrying Amount Accumulated Amortization Net Patents, developed technologies and know-how $ 236,401 $ (29,748 ) $ 206,653 Customer relationships 10,700 (4,672 ) 6,028 Trademarks 6,800 (1,792 ) 5,008 Covenant not to compete 370 (339 ) 31 In-process research and development 7,895 — 7,895 Total $ 262,166 $ (36,551 ) $ 225,615 The balance of in-process research and development includes certain in-process research and development technology acquired in the Company's acquisition of Oxitec in September 2015, and amortization will begin once certain regulatory approvals have been obtained for the in-process programs. In 2017, the Company decided to forgo further development for certain of its in-process research and development assets and, as a result, recorded an impairment charge of $2,950 . Amortization expense was $19,194 , $15,185 and $9,871 for the years ended December 31, 2017 , 2016 and 2015 , respectively. Estimated aggregate amortization expense for definite lived intangible assets is expected to be as follows: 2018 $ 19,258 2019 18,935 2020 18,833 2021 18,645 2022 17,646 Thereafter 133,894 Total $ 227,211 |
Lines of Credit and Long Term D
Lines of Credit and Long Term Debt | 12 Months Ended |
Dec. 31, 2017 | |
Debt Disclosure [Abstract] | |
Lines of Credit and Long Term Debt | Lines of Credit and Long Term Debt Lines of Credit Trans Ova has a $5,000 revolving line of credit with First National Bank of Omaha which matures on May 1, 2018. The line of credit bears interest at the greater of 2.95% above the London Interbank Offered Rate or 3.00% and the actual rate was 4.32% as of December 31, 2017 . As of December 31, 2017 , there was no outstanding balance. The amount available under the line of credit is based on eligible accounts receivable and inventory up to the maximum principal amount. The line of credit is collateralized by certain of Trans Ova's assets and contains certain restricted covenants that include maintaining minimum tangible net worth and working capital and maximum allowable annual capital expenditures. Trans Ova was in compliance with these covenants as of December 31, 2017 . Exemplar has a $700 revolving line of credit with American State Bank which matures on October 30, 2018. The line of credit bears interest at 5.25% per annum. As of December 31, 2017 , there was an outstanding balance of $233 . Long Term Debt Long term debt consists of the following: December 31, 2017 2016 Notes payable $ 5,010 $ 5,453 Royalty-based financing 2,132 1,896 Other 895 599 Long term debt 8,037 7,948 Less current portion 502 386 Long term debt, less current portion $ 7,535 $ 7,562 Trans Ova has a note payable to American State Bank which matures in April 2033 and has an outstanding principal balance of $4,872 as of December 31, 2017 . Trans Ova pays monthly installments of $39 , which includes interest at 3.95% . The note payable is collateralized by certain of Trans Ova's real estate and non-real estate assets. AquaBounty has a royalty-based financing grant from the Atlantic Canada Opportunities Agency, a Canadian government agency, to provide funding of a research and development project. The total amount available under the award was $2,288 , which AquaBounty claimed over a five year period. All amounts claimed by AquaBounty must be repaid in the form of a 10% royalty on any products commercialized out of this research and development project until fully paid. Because the timing of commercialization is subject to additional regulatory considerations, the timing of repayment is uncertain. As of the date of the acquisition by Intrexon in March 2013, AquaBounty had claimed $1,952 of the available funds and this amount was recorded at its acquisition date fair value of $1,107 . The Company accretes the difference of $845 between the face value of amounts drawn and the acquisition date fair value over the expected period of repayment. Subsequent to the acquisition date, AquaBounty claimed the remaining balance available under the grant, resulting in total long term debt of $2,132 as of December 31, 2017 . Future maturities of long term debt are as follows: 2018 $ 502 2019 401 2020 372 2021 832 2022 360 Thereafter 3,438 Total $ 5,905 The AquaBounty royalty-based financing grant is not included in the table above due to the uncertainty of the timing of repayment. |
Income Taxes
Income Taxes | 12 Months Ended |
Dec. 31, 2017 | |
Income Tax Disclosure [Abstract] | |
Income Taxes | Income Taxes The components of loss before income taxes are presented below: Year Ended December 31, 2017 2016 2015 Domestic $ (71,343 ) $ (157,067 ) $ (69,287 ) Foreign (58,357 ) (37,084 ) (17,691 ) Loss before income taxes $ (129,700 ) $ (194,151 ) $ (86,978 ) The components of income tax expense (benefit) are presented below: Year Ended December 31, 2017 2016 2015 U.S. federal income taxes: Current $ 27 $ (17 ) $ 22 Deferred (523 ) 1,396 1,732 Foreign income taxes: Current (379 ) (393 ) (123 ) Deferred (2,269 ) (5,177 ) (1,003 ) State income taxes: Deferred 264 314 388 Income tax expense (benefit) $ (2,880 ) $ (3,877 ) $ 1,016 Income tax expense (benefit) for the years ended December 31, 2017 , 2016 and 2015 differed from amounts computed by applying the applicable U.S. federal corporate income tax rate of 34% to loss before income taxes as a result of the following: 2017 2016 2015 Computed statutory income tax benefit $ (44,098 ) $ (66,011 ) $ (29,573 ) State and provincial income tax benefit, net of federal income taxes (3,294 ) (7,905 ) (3,157 ) Nondeductible stock based compensation 4,147 3,321 3,182 Nondeductible officer compensation 476 — 2,433 Gain on dividend distribution of AquaBounty common stock 3,965 — — Impairment of goodwill 4,700 — — Research and development tax incentives (1,166 ) (6,350 ) (348 ) Acquisition and internal restructuring transaction costs 354 571 883 Provisional impact of the Tax Act 85,288 — — Enacted changes in foreign tax rates and foreign tax reforms 2,138 — (961 ) U.S.-foreign rate differential 5,410 3,463 620 Other, net (64 ) 1,485 (98 ) 57,856 (71,426 ) (27,019 ) Change in valuation allowance for deferred tax assets (60,736 ) 67,549 28,035 Total income tax expense (benefit) $ (2,880 ) $ (3,877 ) $ 1,016 The tax effects of temporary differences that comprise the deferred tax assets and liabilities as of December 31, 2017 and 2016 , are as follows: 2017 2016 Deferred tax assets Allowance for doubtful accounts $ 1,300 $ 1,676 Inventory 489 447 Equity securities and investments in affiliates 17,510 31,729 Accrued liabilities and long-term debt 3,131 4,168 Stock-based compensation 26,936 8,460 Deferred revenue 61,785 68,056 Research and development tax credits 11,385 10,396 Net operating and capital loss carryforwards 111,453 144,502 Total deferred tax assets 233,989 269,434 Less: Valuation allowance 215,582 256,165 Net deferred tax assets 18,407 13,269 Deferred tax liabilities Property, plant and equipment 237 406 Intangible assets 33,790 29,870 Total deferred tax liabilities 34,027 30,276 Net deferred tax liabilities $ (15,620 ) $ (17,007 ) Activity within the valuation allowance for deferred tax assets during the years ended December 31, 2017 , 2016 and 2015 was as follows: 2017 2016 2015 Valuation allowance at beginning of year $ 256,165 $ 190,174 $ 161,660 Increase (decrease) in valuation allowance as a result of Mergers and acquisitions, net — (1,416 ) 1,228 Current year operations 26,619 67,549 28,035 Adoption of ASU 2016-09 17,843 — — Provisional impact of the Tax Act (87,473 ) — — Changes in foreign tax rates and foreign tax reforms 1,327 — — Foreign currency translation adjustment 1,101 (142 ) (749 ) Valuation allowance at end of year $ 215,582 $ 256,165 $ 190,174 In assessing the realizability of deferred tax assets, management considers whether it is more likely than not that some portion or all of the deferred tax assets will not be realized. The ultimate realization of deferred tax assets is dependent upon the generation of future taxable income during the periods in which those temporary differences become deductible. Management considers the scheduled reversal of deferred tax liabilities, projected future taxable income and tax planning strategies in making this assessment. Due to the Company and its subsidiaries' histories of net losses incurred from inception, any corresponding net domestic and certain foreign deferred tax assets have been fully reserved as the Company and its subsidiaries cannot sufficiently be assured that these deferred tax assets will be realized. The components of the deferred tax assets and liabilities as of the date of the mergers and acquisitions by the Company prior to consideration of the valuation allowance are substantially similar to the components of deferred tax assets presented herein. The Company's past issuances of stock and mergers and acquisitions have resulted in ownership changes as defined in Section 382 of the Internal Revenue Code of 1986, as amended ("Section 382"). As a result, utilization of portions of the net operating losses may be subject to annual limitations, however as of December 31, 2017 , all such limited losses applicable to Intrexon, other than losses inherited via acquisition, have been fully utilized. As of December 31, 2017 , approximately $33,590 of the Company's domestic net operating losses were inherited via acquisition, including $13,376 acquired via the acquisition of GenVec, and are limited based on the value of the target at the time of the transaction. As of December 31, 2017 , the Company has loss carryforwards for U.S. federal income tax purposes of approximately $244,274 available to offset future taxable income and federal and state research and development tax credits of $7,737 , prior to consideration of annual limitations that may be imposed under Section 382. These carryforwards will begin to expire in 2022 . The Company's direct foreign subsidiaries have foreign loss carryforwards of approximately $151,423 , most of which do not expire. The Company does not record deferred taxes on the undistributed earnings of its direct foreign subsidiaries because it does not expect the temporary differences related to those unremitted earnings to reverse in the foreseeable future. As of December 31, 2017 , the Company's direct foreign subsidiaries had accumulated deficits of approximately $65,052 . Future distributions of accumulated earnings of the Company's direct foreign subsidiaries may be subject to U.S. income and foreign withholding taxes. The Company is evaluating this accounting assertion in light of the Tax Act. The Company does not file a consolidated income tax return with AquaBounty. As of December 31, 2017 , AquaBounty has loss carryforwards for federal and foreign income tax purposes of approximately $28,209 and $15,653 , respectively, and foreign tax credits of approximately $2,832 available to offset future taxable income, prior to consideration of annual limitations that may be imposed under Section 382 or analogous foreign provisions. These carryforwards will begin to expire in 2018 . As a result of the Company's ownership in AquaBounty passing 50% in 2013, an annual Section 382 of approximately $900 per year will apply to domestic losses and credits carried forward by AquaBounty from prior years, which are also subject to prior Section 382 limitations. The Company recorded a net provisional income tax benefit of $2,185 upon enactment of the Tax Act, which is comprised of several items. Amounts related to the remeasurement of most of the Company's domestic deferred tax assets as a result of the U.S. corporate rate change to 21% as part of the Tax Act are $87,473 , which was fully offset by a reduction in the Company's valuation allowance. The Company's net U.S. deferred tax liability that is not offset by a valuation allowance was similarly written down, and the Company recorded a provisional deferred tax benefit of $1,730 . The Company also recorded a provisional current tax benefit of $455 related to the expected refundability of accumulated corporate alternative minimum tax credits. The Company has provisionally estimated its transition tax exposure to be zero , as any accumulated earnings in foreign subsidiaries are offset by accumulated deficits in other foreign subsidiaries. The provisional amounts recorded are subject to further refinement within the measurement period prescribed by SAB 118. As a result, the recorded amounts are subject to change, possibly materially, due to, among other things, changes in interpretations of the Tax Act, any legislative action to address questions that arise because of the Tax Act, any changes in accounting standards for income taxes or related interpretations in response to the Tax Act, or any updates or changes to estimates the Company utilized to provisionally compute the transition impact. Additionally, in December 2017, Belgium enacted significant tax reform measures, the most significant of which to the Company is the limitation on the utilization of accumulated losses in years after 2017. After that date, loss carryforwards can only be used to offset 70% of taxable income that exceeds a certain threshold. As a result, the Company recorded adjustments to its net deferred tax assets and valuation allowances. These adjustments resulted in a net deferred tax liability of $2,307 , which was recorded as a component of deferred tax expense for the year ended December 31, 2017 . The Company and its subsidiaries do not have material unrecognized tax benefits as of December 31, 2017 . The Company does not anticipate significant changes in the amount of unrecognized tax benefits in the next 12 months. The Company's tax returns for years 2004 and forward are subject to examination by federal or state tax authorities due to the carryforward of unutilized net operating losses and research and development tax credits. |
Shareholders' Equity
Shareholders' Equity | 12 Months Ended |
Dec. 31, 2017 | |
Equity [Abstract] | |
Shareholders' Equity | Shareholders' Equity Issuances of Common Stock In December 2017, the Company entered into a securities purchase agreement with an affiliate of Third Security for the private placement of 1,207,980 shares of the Company's common stock for gross proceeds of $13,686 . In August 2015, the Company closed a public offering of 5,609,756 shares of its common stock, the net proceeds of which were $218,193 , after deducting underwriting discounts of $11,500 and offering expenses paid by the Company of approximately $306 , all of which were capitalized. In January 2015, the Company closed a public offering of 4,312,500 shares of its common stock, including 555,556 shares of common stock purchased by affiliates of Third Security. The net proceeds of the offering were $110,041 , after deducting underwriting discounts and commissions of $6,086 and offering expenses paid by the Company of approximately $311 , all of which were capitalized. Dividends to Shareholders In January 2017, the Company distributed to its shareholders 1,776,557 shares of AquaBounty common stock valued at $22,385 . The distribution constituted a dividend to shareholders of record as of January 9, 2017. In connection with the distribution and pursuant to the terms of the Company's equity incentive plans, the conversion terms of all outstanding options for shares of the Company's common stock as of January 9, 2017 were adjusted to reflect the value of the distribution with respect to shares of the Company's common stock by decreasing the exercise prices and increasing the number outstanding options. This adjustment resulted in 46,766 additional outstanding options at a weighted average exercise price of $31.11 . In June 2015, the Company distributed to its shareholders 17,830,305 shares of ZIOPHARM common stock, representing all of the equity interests of ZIOPHARM held by the Company at the time of the distribution and resulting in a realized gain of $81,401 . The distribution constituted a dividend to shareholders of record as of June 4, 2015. In connection with the distribution, pursuant to the terms of the Company's equity incentive plans, the conversion terms of all outstanding options for shares of the Company's common stock as of June 4, 2015 were adjusted to reflect the value of the distribution with respect to shares of the Company's common stock by decreasing the exercise prices and increasing the number of shares. This adjustment resulted in 312,795 additional outstanding options at a weighted average exercise price of $25.40 . Components of Accumulated Other Comprehensive Loss The components of accumulated other comprehensive loss are as follows: December 31, 2017 2016 Unrealized loss on investments $ (2 ) $ (89 ) Loss on foreign currency translation adjustments (15,552 ) (36,113 ) Total accumulated other comprehensive loss $ (15,554 ) $ (36,202 ) |
Share-Based Payments
Share-Based Payments | 12 Months Ended |
Dec. 31, 2017 | |
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] | |
Share-Based Payments | Share-Based Payments The Company records the fair value of stock options issued to employees and non-employees as of the grant date as stock-based compensation expense. Stock-based compensation expense for employees and non-employees is recognized over the requisite service period, which is typically the vesting period. Stock-based compensation costs included in the consolidated statements of operations are presented below: Year Ended December 31, 2017 2016 2015 Cost of products $ 116 $ 81 $ 95 Cost of services 322 274 354 Research and development 9,336 9,251 8,614 Selling, general and administrative 31,802 32,596 29,604 Total $ 41,576 $ 42,202 $ 38,667 Intrexon Stock Option Plans In April 2008, Intrexon adopted the 2008 Equity Incentive Plan (the "2008 Plan") for employees and nonemployees pursuant to which Intrexon's board of directors granted share based awards, including stock options, to officers, key employees and nonemployees. Upon the effectiveness of the 2013 Omnibus Incentive Plan (the "2013 Plan"), no new awards may be granted under the 2008 Plan. As of December 31, 2017 , there were 453,371 stock options outstanding under the 2008 Plan. Intrexon adopted the 2013 Plan for employees and nonemployees pursuant to which Intrexon's board of directors may grant share-based awards, including stock options, shares of common stock, and other share-based awards, to employees, officers, consultants, advisors, and nonemployee directors. The 2013 Plan became effective upon the closing of the Company's initial public offering in August 2013, and as of December 31, 2017 , there were 18,000,000 shares authorized for issuance under the 2013 Plan, of which 10,929,376 stock options were outstanding and 4,747,496 shares were available for grant. Stock options may be granted with an exercise price equal to or greater than the stock's fair market value at the date of grant. Stock options may be granted with an exercise price less than the stock's fair market value at the date of grant if the stock options are replacement options in accordance with certain U.S. Treasury regulations. Virtually all stock options have ten -year terms and vest four years from the date of grant. Stock option activity was as follows: Number of Shares Weighted Average Exercise Price Weighted Average Remaining Contractual Term (Years) Balances at December 31, 2014 8,323,544 $ 22.59 8.64 Granted 5,051,500 45.82 Adjustment due to dividend (Note 14) 312,795 25.40 Exercised (1,029,291 ) (15.16 ) Forfeited (1,610,335 ) (26.75 ) Expired (4,685 ) (28.29 ) Balances at December 31, 2015 11,043,528 32.66 8.49 Granted 4,644,860 29.39 Exercised (1,210,840 ) (15.83 ) Forfeited (2,760,809 ) (40.34 ) Expired (76,356 ) (37.81 ) Balances at December 31, 2016 11,640,383 31.25 8.21 Granted 3,920,950 21.47 Adjustment due to dividend (Note 14) 46,766 31.11 Exercised (149,429 ) (6.37 ) Forfeited (3,797,105 ) (28.37 ) Expired (278,818 ) (33.18 ) Balances at December 31, 2017 11,382,747 28.99 7.32 Exercisable at December 31, 2017 5,306,697 29.96 6.14 Total unrecognized compensation costs related to unvested awards as of December 31, 2017 were $68,999 , and are expected to be recognized over a weighted-average period of approximately two years . The weighted average grant date fair value of options granted during 2017 , 2016 and 2015 was $12.19 , $16.28 and $25.96 , respectively. The aggregate intrinsic value of options exercised during 2017 , 2016 and 2015 was $2,429 , $22,704 and $24,675 , respectively. The aggregate intrinsic value of options is calculated as the difference between the exercise price of the underlying options and the fair value of Intrexon's common stock for those shares where the exercise price was lower than the fair value of Intrexon's common stock on the date of exercise. The following table summarizes additional information about stock options outstanding as of December 31, 2017 : Options Outstanding Options Exercisable Range of Exercise Prices Number of Options Weighted Average Exercise Price Weighted Average Remaining Life (Years) Aggregate Intrinsic Value Number of Options Weighted Average Exercise Price Weighted Average Remaining Life (Years) Aggregate Intrinsic Value $ 2.64 — $ 9.30 453,371 $ 7.06 3.94 $ 2,020 453,371 $ 7.06 3.94 $ 2,020 $ 12.50 — $ 21.38 3,158,121 20.58 8.74 — 456,942 19.52 7.13 — $ 21.43 — $ 28.81 3,399,721 25.55 6.91 — 1,804,401 25.86 5.69 — $ 28.88 — $ 40.99 2,751,716 32.07 6.70 — 1,732,250 31.51 6.32 — $ 41.41 — $ 65.08 1,619,818 53.52 7.42 — 859,733 53.07 7.38 — 11,382,747 $ 28.99 7.32 $ 2,020 5,306,697 $ 29.96 6.14 $ 2,020 The following table summarizes additional information about stock options outstanding as of December 31, 2016 : Options Outstanding Options Exercisable Range of Exercise Prices Number of Options Weighted Average Exercise Price Weighted Average Remaining Life (Years) Aggregate Intrinsic Value Number of Options Weighted Average Exercise Price Weighted Average Remaining Life (Years) Aggregate Intrinsic Value $ 2.65 — $ 9.34 562,951 $ 6.23 4.13 $ 10,172 525,755 $ 6.01 3.97 $ 9,615 $ 15.21 — $ 27.19 2,785,705 23.47 8.54 4,797 684,704 21.07 7.29 2,237 $ 27.21 — $ 29.68 3,147,242 29.30 7.53 — 1,400,707 29.35 7.31 — $ 29.70 — $ 42.22 3,590,423 32.89 9.09 — 345,274 37.06 6.85 — $ 43.99 — $ 65.34 1,554,062 54.40 8.43 — 461,595 53.06 8.33 — 11,640,383 $ 31.25 8.21 $ 14,969 3,418,035 $ 28.09 6.88 $ 11,852 Intrexon currently uses authorized and unissued shares to satisfy share award exercises. In October 2015, the compensation committee and the independent members of Intrexon's board of directors approved a compensation arrangement whereby the Company's Chief Executive Officer ("CEO") would receive a monthly salary. Previously, the CEO did not receive compensation for his services as an employee of the Company other than through his participation in the Company's Annual Executive Incentive Plan which became effective January 1, 2015. Pursuant to the compensation agreement, the CEO receives a base salary of $200 per month payable in fully vested shares of Intrexon common stock with such shares subject to a three -year lock-up on resale. The monthly number of shares of common stock is calculated based on the closing price on the last trading day of each month and the shares are issued pursuant to the terms of a Restricted Stock Unit Agreement ("RSU Agreement") which was executed between Intrexon and the CEO pursuant to the terms of the 2013 Plan. The RSU Agreement became effective in November 2015 and had an initial term of twelve months . The independent members of Intrexon's board of directors, with the recommendation of the compensation committee of the board of directors, subsequently approved extensions of the RSU Agreement through March 31, 2018, all of which are on the same terms as the original RSU Agreement. The fair value of the shares issued as compensation for services is included in selling, general, and administrative expenses in the Company's consolidated statements of operations for the years ended December 31, 2017 , 2016 and 2015 , and totaled $1,908 , $1,861 , and $314 , respectively. AquaBounty Stock Option Plans In March 2016, AquaBounty's board of directors adopted the AquaBounty 2016 Equity Incentive Plan ("AquaBounty 2016 Plan") to replace the AquaBounty 2006 Equity Incentive Plan ("AquaBounty 2006 Plan"). The AquaBounty 2016 Plan provides for the issuance of incentive stock options, non-qualified stock options and awards of restricted and direct stock purchases to directors, officers, employees, and consultants of AquaBounty. The AquaBounty 2016 Plan was approved by AquaBounty's shareholders at its annual meeting in April 2016. Upon the effectiveness of the AquaBounty 2016 Plan, no new awards may be granted under the AquaBounty 2006 Plan. As of December 31, 2017 , there were 227,203 options outstanding under both AquaBounty plans, of which 192,748 were exercisable, at a weighted average exercise price of $9.39 per share. As of December 31, 2016 , there were 185,591 options outstanding under these plans, of which 181,766 were exercisable, at a weighted average exercise price of $7.89 per share. |
License Agreement
License Agreement | 12 Months Ended |
Dec. 31, 2017 | |
License Agreement [Abstract] | |
License Agreement | License Agreement In January 2015, the Company and ZIOPHARM jointly entered into a license agreement with the University of Texas System Board of Regents on behalf of the University of Texas MD Anderson Cancer Center ("MD Anderson") whereby the Company received an exclusive license to certain research and development technologies owned and licensed by MD Anderson, including technologies relating to novel chimeric antigen receptor (CAR) T-cell therapies, as well as co-licenses and non-exclusive licenses to certain other related technologies. ZIOPHARM received access to these technologies pursuant to the terms of the Company's ECC with ZIOPHARM. The Company issued 2,100,085 shares of its common stock valued at $59,579 to MD Anderson as consideration, which is included in research and development expenses in the accompanying consolidated statement of operations for the year ended December 31, 2015. Subject to certain exceptions, the license agreement expires on the last to occur of (i) the expiration of all patents licensed thereunder, or (ii) the twentieth anniversary of the date of the license agreement. In connection with the license agreement, the Company, ZIOPHARM, and MD Anderson entered into a research and development agreement which governs certain operational activities between the parties and pursuant to which ZIOPHARM provided funding for certain research and development activities of MD Anderson for a period of three years , in an amount between $15,000 and $20,000 per year. The Company and ZIOPHARM reimburse MD Anderson for out of pocket expenses for maintaining patents covering the licensed technologies. |
Commitments and Contingencies
Commitments and Contingencies | 12 Months Ended |
Dec. 31, 2017 | |
Commitments and Contingencies Disclosure [Abstract] | |
Commitments and Contingencies | Commitments and Contingencies Operating Leases The Company leases certain facilities and equipment under noncancelable operating leases. The equipment leases are renewable at the option of the Company. As of December 31, 2017 , future minimum lease payments under operating leases having initial or remaining noncancelable lease terms in excess of one year are as follows: 2018 $ 7,964 2019 9,115 2020 9,186 2021 8,299 2022 7,279 Thereafter 26,044 Total $ 67,887 Rent expense, including other facility expenses, was $11,064 , $8,593 and $8,610 in 2017 , 2016 and 2015 , respectively. The Company maintains subleases for certain of its facilities. Rental income under sublease agreements was $137 , $1,051 and $1,486 for the years ended December 31, 2017 , 2016 and 2015 , respectively. Future rental income is expected to be $104 in 2018 , $120 in 2019 , $55 in 2020 , $56 in 2021 , $58 in 2022 , and $310 thereafter. Purchase Commitments As of December 31, 2017 , the Company had outstanding contractual purchase commitments of $15,802 , which primarily relate to amounts that will be paid in 2018, 2019, and 2020 upon delivery of commercial non-browning apple trees. Contingencies In March 2012, Trans Ova was named as a defendant in a licensing and patent infringement suit brought by XY, LLC ("XY") alleging that certain of Trans Ova's activities breached a 2004 licensing agreement and infringed on patents that XY allegedly owned. Trans Ova filed a number of counterclaims in the case. In Colorado District Court, the matter proceeded to a jury trial in January 2016. The jury determined that XY and Trans Ova had each breached the licensing agreement and that Trans Ova had infringed XY's patents. In April 2016, the court issued its post-trial order, awarding $528 in damages to Trans Ova and $6,066 in damages to XY. The order also provided Trans Ova with a compulsory license to XY's technology, subject to an ongoing royalty obligation. Both parties appealed the court's order, which appeal is pending before the Court of Appeals for Federal Circuit. Since the inception of the 2004 agreement, Trans Ova has remitted payments to XY pursuant to the terms of that agreement and has recorded these payments in cost of services in the consolidated statements of operations for the respective periods. For the period from inception of the 2004 agreement through the court's April 2016 order, aggregate royalty and license payments were $3,170 , of which $2,759 had not yet been deposited by XY. For the year ended December 31, 2016, the Company recorded litigation expense of $4,228 , which is included in selling, general and administrative expenses on the accompanying consolidated statement of operations and represents the excess of the net damages awarded to XY, including prejudgment interest, over the liability previously recorded by Trans Ova for uncashed checks previously remitted to XY. In August 2016, Trans Ova deposited the net damages amount, including prejudgment interest, into the court's treasury, to be held until the appeals process is complete and final judgment amounts are determined. As of December 31, 2017 , this amount is included in restricted cash on the accompanying consolidated balance sheet. In December 2016, Trans Ova elected to void the outstanding checks discussed above, and these amounts have been reclassified to other accrued liabilities on the accompanying consolidated balance sheets as of December 31, 2017 and 2016 . Depending on the outcome of an appeal decision, the damages awarded to either party could decrease, increase, or be eliminated. The appeal decision may also remand to the Colorado District Court all, or a portion, of the issues being appealed. In December 2016, XY filed a complaint for patent infringement and trade secret misappropriation against Trans Ova in the District Court of Waco, Texas. Since the claims in this 2016 complaint directly relate to the 2012 licensing dispute and patent issues, Trans Ova filed and was granted a motion for change of venue to Colorado District Court. Trans Ova also filed a motion to dismiss, from which the Court recently dismissed nine of the twelve counts of the complaint. Presently, three counts for patent infringement remain pending. Trans Ova and the Company could elect to enter into a settlement agreement in order to avoid the further costs and uncertainties of litigation, to modify the court-ordered license to XY's technologies, or to recover monetary damages stemming from Trans Ova's counterclaims for antitrust violations by XY and its parent company, Inguran. In May 2016, two putative shareholder class action lawsuits, captioned Hoffman v. Intrexon Corporation et al. and Gibrall v. Intrexon Corporation et al. , were filed in the U.S. District Court for the Northern District of California on behalf of purchasers of Intrexon's common stock between May 12, 2015 and April 20, 2016 (the "Class Period"). In July 2016, the court consolidated the lawsuits and appointed a lead plaintiff. The consolidated amended complaint names as defendants Intrexon and certain of Intrexon's current and former officers (the "Defendants"). It alleges, among other things, that the Defendants made materially false and/or misleading statements during the Class Period with respect to the Company's business, operations, and prospects in violation of Sections 10(b) and 20(a) of the Securities Exchange Act of 1934, as amended. The plaintiffs' claims are based in part upon allegations in a report published in April 2016 on the Seeking Alpha financial blog. The plaintiffs seek compensatory damages, interest and an award of reasonable attorneys' fees and costs. The Defendants moved to dismiss the case. On February 24, 2017, the court granted the Defendants' motion to dismiss the lawsuit on the grounds that the plaintiff failed to state a claim, while granting the plaintiff leave to amend. The plaintiff subsequently notified the court that it would seek to appeal the court's ruling rather than amend its complaint. On April 26, 2017, the court entered final judgment in the case. Notice of appeal was filed by the plaintiff on May 26, 2017. On October 26, 2017, the plaintiff filed a voluntary motion to dismiss the case, which the court of appeals granted on November 1, 2017. In July 2016, a putative shareholder derivative action captioned Basile v. Kirk et al. was filed in the Circuit Court of Fairfax County, Virginia, against certain of the Company's directors, the Company's CEO, and Third Security, and naming the Company as a nominal defendant. The complaint alleges causes of action for breaches of fiduciary duty and unjust enrichment relating to the entry by the Company into the Services Agreement with Third Security. The plaintiff seeks, among other things, damages in an unspecified amount, disgorgement of improper benefits, appropriate equitable relief, and an award of attorney fees and other costs and expenses. The complaint is substantially similar to two separate demands made by shareholders concerning the Services Agreement and Mr. Kirk's compensation. The board of directors of the Company appointed a Special Litigation Committee ("SLC") consisting of independent directors to investigate the claims and allegations made in the derivative action and in the two shareholder demands and to decide on behalf of the Company whether the claims and allegations should be pursued. The Basile case was stayed pending the report of the SLC. In November 2016, the SLC completed its review and evaluation and unanimously determined that the claims were without merit because the compensation arrangements were the result of an informed and disinterested decision-making process and were fair to the Company, and that prosecution of the asserted claims was not in the best interest of Intrexon or its shareholders. Based upon the determination of the SLC, on February 24, 2017, the Company moved to dismiss the court action pursuant to Virginia statute. On June 8, 2017, the court granted the Company's motion to dismiss while granting the plaintiff leave to amend. On August 30, 2017, the plaintiff filed a consent motion for leave to amend along with the amended shareholder derivative complaint. The Company moved to dismiss the amended complaint on October 6, 2017. On January 25, 2018, the court granted the Company's motion and dismissed the plaintiff's amended complaint with prejudice. In addition to the shareholder demands above, in June and July 2016, two shareholders made separate demands under Virginia law demanding that the Company file suit against certain of its current officers and directors for alleged breaches of fiduciary duty and other claims. The demands were based upon and asserted the allegations previously published in April 2016 in the Seeking Alpha financial blog. In July 2016, the Company's board of directors authorized the SLC to expand its review to include all such allegations. In February 2017, the SLC completed its review and evaluation and unanimously determined that there was no basis for any of the allegations, that the Company's officers and directors did not breach their fiduciary duties or any other applicable law, and that prosecution of the asserted claims was not in the best interest of Intrexon or its shareholders. Following the SLC's determination, in March 2017, one of the putative shareholders filed a derivative complaint captioned Luger v. Kirk et al. in the Circuit Court of Fairfax County, Virginia. The Company is a nominal defendant in this action, and other defendants include certain of the Company's directors, the Company's CEO, and Third Security. The complaint alleges causes of action for breaches of fiduciary duty and unjust enrichment relating to the entry by the Company into the Services Agreement with Third Security, Mr. Kirk's compensation, and certain allegations contained in the April 2016 Seeking Alpha financial blog piece. Based on the determination of the SLC and a review of applicable law, the Company intends to defend the lawsuit vigorously; however, there can be no assurance regarding the ultimate outcome of this case. The Division of Enforcement of the U.S. Securities and Exchange Commission ("SEC") is conducting an investigation which the Company believes concerns certain issues raised by the foregoing matters. The Company has met with the SEC staff and is voluntarily cooperating with their investigation. The Company's board of directors has authorized the SLC to monitor the Company's interaction with the SEC staff. The Company may become subject to other claims and assessments from time to time in the ordinary course of business. Such matters are subject to many uncertainties and outcomes are not predictable with assurance. The Company accrues liabilities for such matters when it is probable that future expenditures will be made and such expenditures can be reasonably estimated. As of December 31, 2017 and 2016 , the Company does not believe that any such matters, individually or in the aggregate, will have a material adverse effect on the Company's business, financial condition, results of operations, or cash flows. |
Related Party Transactions
Related Party Transactions | 12 Months Ended |
Dec. 31, 2017 | |
Related Party Transactions [Abstract] | |
Related Party Transactions | Related Party Transactions Third Security and Affiliates The Company's CEO and Chairman of the board of directors is also the Senior Managing Director and CEO of Third Security and owns 100% of the equity interests of Third Security. In November 2015, the independent members of Intrexon's board of directors, with the recommendation of the audit committee of the board of directors, approved the execution of a Services Agreement ("Services Agreement") with Third Security pursuant to which Third Security provides the Company with certain professional, legal, financial, administrative, and other support services necessary to support the Company and its CEO. As consideration for providing these services, Third Security is entitled to a fee of $800 per month to be paid in the form of fully-vested shares of the Company's common stock. The number of shares of common stock is calculated based on the closing price of the Company's common stock on the 15th day of each month. The payments made by the Company under the Services Agreement constitute, in the aggregate, an award under the 2013 Plan and are subject to the terms of the 2013 Plan (Note 15 ). The Services Agreement had a term of one year , can be terminated by the Company at any time, and may be extended only by agreement of the parties, including approval of a majority of the independent members of Intrexon's board of directors. The independent members of Intrexon's board of directors, with the recommendation of the audit committee of the board of directors, subsequently approved extensions of the Services Agreement through January 1, 2019. For the years ended December 31, 2017 , 2016 and 2015 , the Company issued 500,650 shares, 337,163 shares, and 48,678 shares, respectively, with values of $8,704 , $8,571 , and $1,375 , respectively, to Third Security as payment for services pursuant to the Services Agreement. In addition to the foregoing Services Agreement, the Company reimburses Third Security for certain out-of-pocket expenses incurred on the Company's behalf, and the total expenses incurred by the Company under this arrangement was $409 , $309 , and $428 for the years ended December 31, 2017 , 2016 and 2015 , respectively. See also Note 15 regarding compensation arrangements between the Company and its CEO. In October 2017, the Company entered into a Preferred Stock Equity Facility ("Preferred Stock Facility") with an affiliate of Third Security ("Third Security Affiliate"). Under the Preferred Stock Facility, the Company may, from time to time at its sole and exclusive option, issue and sell to the Third Security Affiliate, up to $100,000 of newly issued Series A Redeemable Preferred Stock ("Series A Preferred Stock"). Any issued Series A Preferred Stock is non-voting, accrues dividends of 8% per annum and, subject to limited exceptions, is senior to Intrexon's common stock with respect to the rights to the payment of dividends and on parity with the common stock with respect to the distribution of assets in the event of any liquidation, dissolution or winding up or change of control of Intrexon. Any issued Series A Preferred Stock is convertible into common stock only following receipt of shareholder approval by the Company, including a majority of the shares voted by those shareholders unaffiliated with Mr. Kirk (the "Shareholder Approval"), subject to any necessary regulatory approvals. Following receipt of the Shareholder Approval and receipt of any necessary regulatory approvals, any issued Series A Preferred Stock is convertible into Intrexon common stock based on a conversion price using the 20 -day volume-weighted average market price as of market closing on the fifth business day prior to the mailing of the proxy statement soliciting the Shareholder Approval, subject to adjustment for certain stock splits and similar events. The Company has agreed to take all reasonable steps necessary to seek Shareholder Approval on or before the date of its annual meeting of shareholders in 2019. Any issued Series A Preferred Stock is redeemable at the election of the Company at any time, or at the election of the Third Security Affiliate after December 31, 2020. The Preferred Stock Facility will expire on the earliest to occur of: (i) the date on which the Third Security Affiliate has purchased shares of Series A Preferred Stock in the aggregate amount of $100,000 , (ii) April 30, 2019, (iii) the date of the Shareholder Approval, and (iv) the mutual agreement of the parties. To date, the Company has not utilized the Preferred Stock Facility. See additional discussion regarding Third Security's participation in the Company's equity offerings at Notes 14 and 22 . The Company also subleases certain administrative offices to Third Security. The significant terms of the lease mirror the terms of the Company's lease with the landlord, and the Company recorded sublease income of $43 for each of the years ended December 31, 2017 , 2016 and 2015 . Transactions with ECC Parties In addition to entities controlled by Third Security, any entity in which the Company holds equity securities, including securities received as upfront or milestone consideration, and which also are party to a collaboration with the Company are considered to be related parties. In December 2017, the Company purchased certain property and equipment comprising the pilot plant production facility for its energy programs for $2,812 from Intrexon Energy Partners. The Company intends to use the pilot plant to support the collaborations with Intrexon Energy Partners and Intrexon Energy Partners II and its own research programs. The Company holds a promissory note convertible into shares of Fibrocell common stock ("convertible note") and warrants to purchase shares of Fibrocell common stock. As of December 31, 2017 and 2016 , the value of the convertible note and warrants totaled $575 and $1,642 , respectively, and is included in other assets on the accompanying consolidated balance sheets. In July 2015, the Company purchased 125,290 shares of common stock of Fibrocell at $17.40 per share. The share data reflect a 1-for-3 reverse stock split of Fibrocell's common stock effective March 10, 2017. In June 2016, the Company purchased 226,142 shares of Oragenics common stock at $5.20 per share. The share data reflect a 1-for-10 reverse stock split of Oragenics' common stock effective January 19, 2018. In March 2015, the Company purchased 27,879 shares of common stock of AmpliPhi Biosciences Corporation ("AmpliPhi") and 6,969 warrants for $2,300 . The share and warrant data reflect a 1-for-10 reverse stock split of AmpliPhi's common stock effective April 24, 2017. Of the total purchase price, $1,979 was allocated to the value of the shares of common stock and $321 was allocated to the value of the warrants. In December 2016, the Company sold all of its investment in AmpliPhi common stock, resulting in a realized loss of $4,098 , which is included in unrealized and realized depreciation in fair value of equity securities on the consolidated statement of operations for the year ended December 31, 2016. In February 2015, the Company purchased $12,600 of ZIOPHARM common stock. See Note 14 for additional discussion related to the Company's investment in ZIOPHARM. Other Related Parties In June 2015, the Company entered into an agreement with Harvest, an investment fund sponsored by Harvest Capital Strategies, LLC, and a related party based on ownership in the fund by affiliates of Third Security. Harvest was established to invest in life science research and development start-up opportunities that the Company offered to Harvest with exclusive rights of first-look and first negotiation. Based on this agreement, Harvest established six new collaboration entities, each of which entered into an ECC with the Company in a designated field. The terms of such ECCs were negotiated between the Company and Harvest. As consideration for providing exclusive rights of first-look and first negotiation for start-up opportunities, the Company received a portion of the management fee collected by the fund sponsor of Harvest. These fees are included in other income in the accompanying consolidated statements of operations and totaled $1,839 , $2,483 , and $1,349 for the years ended December 31, 2017 , 2016 and 2015 , respectively. In September 2017, the commitment period for Harvest was terminated and, as a result, the agreement with Harvest terminated. The termination of the agreement had no effect on the existing collaborations with Harvest-controlled entities. |
Net Loss per Share
Net Loss per Share | 12 Months Ended |
Dec. 31, 2017 | |
Earnings Per Share [Abstract] | |
Net Loss per Share | Net Loss per Share The following table presents the computation of basic and diluted net loss per share: 2017 2016 2015 Historical net loss per share: Numerator: Net loss attributable to Intrexon $ (117,018 ) $ (186,612 ) $ (84,493 ) Denominator: Weighted average shares outstanding, basic and diluted 119,998,826 117,983,836 111,066,352 Net loss attributable to Intrexon per share, basic and diluted $ (0.98 ) $ (1.58 ) $ (0.76 ) The following potentially dilutive securities as of December 31, 2017 , 2016 , and 2015 , have been excluded from the above computations of diluted weighted average shares outstanding for the years then ended as they would have been anti-dilutive: December 31, 2017 2016 2015 Options 11,382,747 11,640,383 11,043,528 Warrants 133,264 — 194,719 Total 11,516,011 11,640,383 11,238,247 |
Quarterly Financial Information
Quarterly Financial Information (Unaudited) | 12 Months Ended |
Dec. 31, 2017 | |
Quarterly Financial Information Disclosure [Abstract] | |
Quarterly Financial Information (Unaudited) | Quarterly Financial Information (Unaudited) The following information has been derived from unaudited consolidated statements that, in the opinion of management, include all recurring adjustments necessary for a fair statement of such information. Three Months Ended March 31, June 30, September 30, December 31, 2017 (1) Total revenues $ 53,504 $ 54,433 $ 46,016 $ 77,028 Operating loss (31,381 ) (35,270 ) (44,747 ) (26,492 ) Net loss (32,377 ) (19,662 ) (40,836 ) (33,945 ) Net loss attributable to Intrexon (31,399 ) (18,664 ) (39,689 ) (27,266 ) Net loss attributable to Intrexon per share, basic and diluted $ (0.26 ) $ (0.16 ) $ (0.33 ) $ (0.23 ) Three Months Ended March 31, June 30, September 30, December 31, Total revenues $ 43,438 $ 52,501 $ 48,985 $ 46,002 Operating loss (40,533 ) (23,222 ) (28,821 ) (32,590 ) Net loss (65,320 ) (50,031 ) (30,011 ) (44,912 ) Net loss attributable to Intrexon (64,429 ) (49,064 ) (28,982 ) (44,137 ) Net loss attributable to Intrexon per share, basic and diluted $ (0.55 ) $ (0.42 ) $ (0.24 ) $ (0.37 ) (1) During the fourth quarter of 2017, the Company recognized the remaining balance of deferred revenue associated with ZIOPHARM ECC2 upon the parties' mutual agreement to terminate (Note 5 ). The Company also recorded goodwill impairment charges primarily related to the AquaBounty reporting unit and an impairment charge related to certain of its in-process research and development assets (Note 11 ). |
Defined Contribution Plans
Defined Contribution Plans | 12 Months Ended |
Dec. 31, 2017 | |
Retirement Benefits [Abstract] | |
Defined Contribution Plans | Defined Contribution Plans The Company sponsors defined contribution plans covering employees who meet certain eligibility requirements. The Company makes contributions to the plans in accordance with terms specified in the plan agreement. The Company's contributions to the plans were $2,367 , $1,857 and $1,157 in 2017 , 2016 and 2015 , respectively. |
Subsequent Events
Subsequent Events | 12 Months Ended |
Dec. 31, 2017 | |
Subsequent Events [Abstract] | |
Subsequent Events | Subsequent Events In January 2018, the Company closed a public offering of 6,900,000 shares of its common stock, including 1,000,000 shares of common stock purchased by affiliates of Third Security. The net proceeds of the offering were $82,242 , after deducting underwriting discounts of $3,688 and estimated offering expenses of approximately $320 , all of which were capitalized. In January 2018, Intrexon purchased $5,000 of additional AquaBounty common stock through an underwritten public offering, reducing its ownership stake from approximately 58% to approximately 53% . In February 2018, OvaScience provided their notice of termination of the ECC between them and the Company, to be effective in May 2018 in accordance with the ECC agreement. As a result, the Company will recognize the remaining balance of the deferred revenue associated with this ECC agreement totaling $3,183 in 2018. The Company and OvaScience are in discussions regarding dissolving the OvaXon joint venture and terminating the related ECC agreement. |
Summary of Significant Accoun31
Summary of Significant Accounting Policies (Policies) | 12 Months Ended |
Dec. 31, 2017 | |
Accounting Policies [Abstract] | |
Principles of Consolidation | Principles of Consolidation The accompanying consolidated financial statements reflect the operations of the Company and its subsidiaries. All intercompany accounts and transactions have been eliminated. |
Revenue Recognition | Revenue Recognition The Company generates collaboration and licensing revenue through the execution of agreements with collaborators (known as exclusive channel collaborations, "ECC" or "ECCs") and licensing agreements whereby the collaborators or the licensee obtain exclusive access to the Company's proprietary technologies for use in the research, development and commercialization of products and/or treatments in a contractually specified field of use. Generally, the terms of these agreements provide that the Company receives some or all of the following: (i) upfront payments upon consummation of the agreement, (ii) reimbursements for costs incurred by the Company for research and development and/or manufacturing efforts related to specific applications provided for in the agreement, (iii) milestone payments upon the achievement of specified development, regulatory and commercial activities, and (iv) royalties on sales of products arising from the collaboration or licensing agreement. The Company's collaboration and licensing agreements typically contain multiple elements, or deliverables, including technology licenses, research and development services, and in certain cases manufacturing services. The Company identifies the deliverables within the agreements and evaluates which deliverables represent separate units of accounting. Analyzing the agreements to identify deliverables requires the use of judgment. A deliverable is considered a separate unit of accounting when the deliverable has value to the collaborator or licensee on a standalone basis based on the consideration of the relevant facts and circumstances for each agreement. Consideration received is allocated at the inception of the agreement to all identified units of accounting based on their relative selling price. When available, the relative selling price for each deliverable is determined using vendor specific objective evidence ("VSOE") of the selling price or third-party evidence of the selling price, if VSOE does not exist. If neither VSOE nor third-party evidence of the selling price exists, the Company uses its best estimate of the selling price for the deliverable. The amount of allocable consideration is limited to amounts that are fixed or determinable. The consideration received is allocated among the separate units of accounting, and the applicable revenue recognition criteria are applied to each of the separate units. The Company recognizes the revenue allocated to each unit of accounting as the Company delivers the related goods or services. If the Company determines that certain deliverables should be treated as a single unit of accounting, then the revenue is recognized using either a proportional performance or straight-line method, depending on whether the Company can reasonably estimate the level of effort required to complete its performance obligations under an arrangement and whether such performance obligations are provided on a best-efforts basis. As the Company cannot reasonably estimate its performance obligations related to its collaborators or licensees, the Company recognizes revenue on a straight-line basis over the period it expects to complete its performance obligations, which is reevaluated each reporting period. The terms of the Company's agreements may provide for milestone payments upon achievement of certain defined events. The Company applies the Milestone Method for recognizing milestone payments. Under the Milestone Method, the Company recognizes consideration that is contingent upon the achievement of a milestone in its entirety as revenue in the period in which the milestone is achieved only if the milestone is substantive in its entirety. A milestone is considered substantive when it meets all of the following criteria: (1) The consideration is commensurate with either the entity's performance to achieve the milestone or the enhancement of the value of the delivered item or items as a result of a specific outcome resulting from the entity's performance to achieve the milestone; (2) The consideration relates solely to past performance; and (3) The consideration is reasonable relative to all of the deliverables and payment terms within the arrangement. In the event that a milestone is not considered substantive, the Company recognizes the milestone consideration as revenue using the same method applied to upfront payments. Research and development services are a deliverable satisfied by the Company in accordance with the terms of the collaboration and licensing agreements and the Company considers these services to be inseparable from the license to the core technology; therefore, reimbursements of services performed are recognized as revenue. Because reimbursement (i) is contingent upon performance of the services by the Company, (ii) does not include a profit component, and (iii) does not relate to any future deliverable, the revenue is recognized during the period in which the related services are performed and collection of such amounts is reasonably assured. Payments received for manufacturing services will be recognized when the earnings process related to the manufactured materials has been completed. Royalties to be received under the agreements will be recognized as earned. From time to time, the Company and certain collaborators may cancel their agreements, relieving the Company of any further performance obligations under the agreement. When no further performance obligations are required of the Company under an agreement, the Company recognizes any remaining deferred revenue. The Company generates product and service revenues primarily through sales of products and services which are created from technologies developed or owned by the Company. The Company's current offerings include sales of advanced reproductive technologies, including the Company's bovine embryo transfer and in vitro fertilization processes and from genetic preservation and sexed semen processes and applications of such processes to other livestock, as well as sales of livestock and embryos produced using these processes and used in production. Revenue is recognized when (i) persuasive evidence of an arrangement exists, (ii) services have been rendered or delivery has occurred such that risk of loss has passed to the customer, (iii) the price is fixed or determinable, and (iv) collection from the customer is reasonably assured. |
Research and Development | Research and Development The Company considers that regulatory requirements inherent in the research and development of new products preclude it from capitalizing such costs. Research and development expenses include salaries and related costs of research and development personnel, including stock-based compensation expense, and the costs of consultants, certain in-licensed technology rights, facilities, materials and supplies associated with research and development projects as well as various laboratory studies. Indirect research and development costs include depreciation, amortization and other indirect overhead expenses. |
Cash and Cash Equivalents | Cash and Cash Equivalents All highly liquid investments with an original maturity of three months or less at the date of purchase are considered to be cash equivalents. Cash balances at a limited number of banks may periodically exceed insurable amounts. The Company believes that it mitigates its risk by investing in or through major financial institutions with high quality credit ratings. Recoverability of investments is dependent upon the performance of the issuer. |
Restricted Cash | Restricted Cash Restricted cash represents funds deposited with the U.S. Treasury, as required by a court decision resulting from litigation against Trans Ova (Note 17 ). |
Short-term and Long-term Investments | Short-term and Long-term Investments As of December 31, 2017 , short-term investments include U.S. government debt securities and certificates of deposit. The Company determines the appropriate classification as short-term or long-term at the time of purchase based on original maturities and management's reasonable expectation of sales and redemption. The Company reevaluates such classification at each balance sheet date. The Company's written investment policy requires investments to be explicitly rated by two of the three following rating services: Standard & Poor's, Moody's and/or Fitch and to have a minimum rating of A1, P1 and/or F-1, respectively, from those agencies. In addition, the investment policy limits the amount of credit exposure to any one issuer. |
Equity Securities | Equity Securities The Company holds equity securities received and/or purchased from certain collaborators. Other than investments accounted for using the equity method, the Company elected the fair value option to account for its equity securities held in these collaborators. These equity securities are recorded at fair value at each reporting date and are subject to market price volatility. Unrealized gains and losses resulting from fair value adjustments are reported in the consolidated statement of operations. The fair value of these equity securities is subject to fluctuation in the future due to the volatility of the stock market, changes in general economic conditions and changes in the financial conditions of these collaborators. Equity securities that the Company does not intend to sell within one year are classified as noncurrent in the consolidated balance sheet. The Company records the fair value of securities received on the date the collaboration is consummated or the milestone is achieved using the closing, quoted price of the collaborator's security on that date, assuming the transfer of consideration is considered perfunctory. If the transfer of the consideration is not considered perfunctory, the Company considers the specific facts and circumstances to determine the appropriate date on which to evaluate fair value. The Company also evaluates whether any discounts for trading restrictions or other basis for lack of marketability should be applied to the fair value of the securities at inception of the collaboration. In the event the Company concludes that a discount should be applied, the fair value of the securities is adjusted at inception of the collaboration and re-evaluated at each reporting period thereafter. |
Investment in Preferred Stock | Investments in Preferred Stock The Company holds preferred stock in certain of its collaborators, most of which may be converted to common stock as described in Note 7 . The Company elected the fair value option to account for its investments in preferred stock whereby the value of preferred stock is adjusted to fair value as of each reporting date and unrealized gains and losses are reported in the consolidated statement of operations. These investments are subject to fluctuation in the future due to, among other things, the likelihood and timing of conversion of certain of the preferred stock into common stock, the volatility of each collaborator's common stock, and changes in general economic and financial conditions of the collaborators. The investments are classified as noncurrent in the consolidated balance sheet since the Company does not intend to sell the investments nor expect the investments that are convertible into common stock to be converted within one year. The Company is entitled to monthly dividends and records dividend income as described in Note 7 . |
Fair Value of Financial Instruments | Fair Value of Financial Instruments Fair value is the price that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants at the measurement date. As such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset and liability. As a basis for considering such assumptions, the Company uses a three-tier fair value hierarchy that prioritizes the inputs used in its fair value measurements. The hierarchy gives the highest priority to unadjusted quoted prices in active markets for identical assets or liabilities (Level 1 measurements) and the lowest priority to unobservable inputs (Level 3 measurements). The three levels of the fair value hierarchy are as follows: Level 1: Quoted prices in active markets for identical assets and liabilities; Level 2: Other than quoted prices included in Level 1 inputs that are observable for the asset or liability, either directly or indirectly; and Level 3: Unobservable inputs for the asset or liability used to measure fair value to the extent that observable inputs are not available. |
Concentrations of Risk | Concentrations of Risk Due to the Company's mix of fixed and variable rate securities holdings, the Company's investment portfolio is susceptible to changes in interest rates. As of December 31, 2017 , gross unrealized losses on the Company's short-term investments were not material. From time to time, the Company may liquidate some or all of its investments to fund operational needs or other activities, such as capital expenditures or business acquisitions, or distribute its equity securities to shareholders as a stock dividend. Depending on which investments the Company liquidates to fund these activities, the Company could recognize a portion, or all, of the gross unrealized losses. Financial instruments which potentially subject the Company to concentrations of credit risk consist primarily of trade and related party receivables. The Company controls credit risk through credit approvals, credit limits and monitoring procedures. The Company performs ongoing credit evaluations of its customers but generally does not require collateral to support accounts receivable. |
Equity Method Investments | Equity Method Investments The Company accounts for its investments in each of its joint ventures and for its investments in start-up entities backed by the Harvest Intrexon Enterprise Fund I, LP ("Harvest"), a related party, (Note 18 ) using the equity method of accounting based upon relative ownership interest. The Company's investments in these entities are included in investments in affiliates in the accompanying consolidated balance sheets. The Company accounts for its investment in Oragenics, Inc. ("Oragenics"), one of its collaborators, using the fair value option. |
Variable Interest Entities | Variable Interest Entities The Company identifies entities that (i) do not have sufficient equity investment at risk to permit the entity to finance its activities without additional subordinated financial support or (ii) in which the equity investors lack an essential characteristic of a controlling financial interest as variable interest entities ("VIE" or "VIEs"). The Company performs an initial and on-going evaluation of the entities with which the Company has variable interests to determine if any of these entities are VIEs. If an entity is identified as a VIE, the Company performs an assessment to determine whether the Company has both (i) the power to direct activities that most significantly impact the VIE's economic performance and (ii) have the obligation to absorb losses from or the right to receive benefits of the VIE that could potentially be significant to the VIE. If both of these criteria are satisfied, the Company is identified as the primary beneficiary of the VIE. |
Trade Receivables | Trade Receivables Trade receivables consist of credit extended to the Company's customers in the normal course of business and are reported net of an allowance for doubtful accounts. The Company reviews its customer accounts on a periodic basis and records bad debt expense for specific amounts the Company evaluates as uncollectible. Past due status is determined based upon contractual terms. Amounts are written off at the point when collection attempts have been exhausted. Management estimates uncollectible amounts considering such factors as current economic conditions and historic and anticipated customer performance. This estimate can fluctuate due to changes in economic, industry or specific customer conditions which may require adjustment to the allowance recorded by the Company. Management has included amounts believed to be uncollectible in the allowance for doubtful accounts. |
Inventory | Inventory The Company's inventory primarily includes adult female cows which are used in certain production processes and are recorded at acquisition cost using the first-in, first-out method or at market, whichever is lower. Work-in-process inventory includes allocations of production costs and facility costs for products currently in production and is recorded at the lower of cost or market. Significant declines in the price of cows could result in unfavorable adjustments to inventory balances. |
Property, Plant and Equipment | Property, Plant and Equipment Property, plant and equipment are stated at cost, less accumulated depreciation and amortization. Major additions or betterments are capitalized and repairs and maintenance are generally expensed as incurred. Depreciation and amortization is calculated using the straight-line method over the estimated useful lives of the assets. The estimated useful lives of these assets are as follows: Years Land improvements 4–20 Buildings and building improvements 3–25 Furniture and fixtures 1–10 Equipment 1–10 Breeding stock 1–4 Computer hardware and software 1–7 Leasehold improvements are amortized over the shorter of the useful life of the asset or the applicable lease term, generally one to twenty years |
Goodwill | Goodwill Goodwill represents the future economic benefits arising from other assets acquired in a business combination that are not individually identified and separately recognized. Goodwill is reviewed for impairment at least annually. The Company performs a qualitative assessment to determine whether it is more-likely-than-not that the fair value of a reporting unit is less than its carrying amount prior to performing the goodwill impairment test. If this is the case, the goodwill impairment test is required. If it is more-likely-than-not that the fair value of a reporting unit is greater than the carrying amount, the goodwill impairment test is not required. If the goodwill impairment test is required, first, the fair value of the reporting unit is compared with its carrying amount (including goodwill). If the fair value of the reporting unit is less than its carrying amount, an indication of goodwill impairment exists for the reporting unit and the entity must record the impairment charge for the excess carrying amount, which is limited to the amount of goodwill allocated to the reporting unit. If the fair value of the reporting unit exceeds its carrying amount, no goodwill impairment charge is necessary. The Company performs its annual impairment review of goodwill in the fourth quarter, or sooner if a triggering event occurs prior to the annual impairment review. |
Intangible Assets | Intangible Assets Intangible assets subject to amortization consist of patents, developed technologies and know-how; customer relationships; and trademarks acquired as a result of mergers and acquisitions. These intangible assets are subject to amortization, were recorded at fair value at the date of acquisition and are stated net of accumulated amortization. Indefinite-lived intangible assets consist of in-process research and development technologies acquired in mergers or acquisitions and were recorded at fair value at the dates of the respective acquisitions. The Company amortizes long-lived intangible assets to reflect the pattern in which the economic benefits of the intangible asset are expected to be realized. The intangible assets are amortized over their estimated useful lives, ranging from three to twenty-one years for the patents, developed technologies and know-how; customer relationships; and trademarks. |
Impairment of Long-Lived Assets | Impairment of Long-Lived Assets Long-lived assets to be held and used, including property, plant and equipment and intangible assets subject to amortization, are reviewed for impairment whenever events or changes in circumstances indicate that the carrying amount of the assets may not be recoverable. Conditions that would necessitate an impairment assessment include a significant decline in the observable market value of an asset, a significant change in the extent or manner in which an asset is used, or a significant adverse change that would indicate that the carrying amount of an asset or group of assets is not recoverable. Indefinite-lived intangible assets, including in-process research and development, are tested for impairment annually, or more frequently if events or circumstances between annual tests indicate that the asset may be impaired. Impairment losses on indefinite-lived intangible assets are recognized based solely on a comparison of their fair value to carrying value, without consideration of any recoverability test. The Company monitors the progression of its in-process research and development, as the likelihood of success is contingent upon commercial development or regulatory approval. |
Self Insurance Reserves | Self-insurance Reserves Effective January 1, 2017, the Company commenced a self-insurance program for a significant portion of its employee health benefit programs. The Company maintains stop-loss coverage with third party insurers to limit its individual claims and total exposure under those programs. The Company estimates its accrued liability for the ultimate costs to close known claims, including claims incurred but not yet reported to the Company, as of the balance sheet date. The Company's recorded estimated liability for self-insurance is based on the insurance company's incurred loss estimates and management's judgment, including assumptions and factors related to the frequency and severity of claims and the Company's claims development history. The assessment of self-insurance reserves is a highly subjective process that requires judgments about future events. Self-insurance reserves are reviewed at least quarterly to determine the adequacy of the accruals and related financial statement disclosure. The ultimate settlement of self-insurance reserves may differ significantly from amounts the Company has accrued in its consolidated financial statements. |
Foreign Currency Translation | Foreign Currency Translation The assets and liabilities of foreign subsidiaries, where the local currency is the functional currency, are translated from their respective functional currencies into United States dollars at the exchange rates in effect at the balance sheet date, with resulting foreign currency translation adjustments recorded in the consolidated statement of comprehensive loss. Revenue and expense amounts are translated at average rates during the period. |
Income Taxes | Income Taxes Income taxes are accounted for under the asset and liability method. Deferred tax assets and liabilities are recognized for the future tax consequences attributable to both differences between the financial statement carrying amounts of existing assets and liabilities and their respective tax bases as well as operating loss and tax credit carryforwards. Deferred tax assets and liabilities are measured using enacted tax rates expected to apply to taxable income in the years in which those temporary differences are expected to be recovered or settled. The effect on deferred tax assets and liabilities of a change in tax rates is recognized in income in the period that includes the enactment date of the change. Valuation allowances are established when necessary to reduce deferred tax assets to the amount expected to be realized. The Company identifies any uncertain income tax positions and recognizes the effect of income tax positions only if those positions are more likely than not of being sustained. Recognized income tax positions are measured at the largest amount that is greater than 50% likely of being realized. Changes in recognition or measurement are reflected in the period in which the change in judgment occurs. The Company records interest, if any, related to unrecognized tax benefits as a component of interest expense. Penalties, if any, are recorded in selling, general and administrative expenses. |
Share-Based Payments | Share-Based Payments Intrexon uses the Black-Scholes option pricing model to estimate the grant-date fair value of all stock options. The Black-Scholes option pricing model requires the use of assumptions for estimated expected volatility, estimated expected term of stock options, risk-free rate, estimated expected dividend yield, and the fair value of the underlying common stock at the date of grant. Since Intrexon does not have sufficient history to estimate the expected volatility of its common stock price, expected volatility is based on a blended approach which utilizes the volatility of Intrexon's common stock and the volatility of peer public entities that are similar in size and industry. Intrexon estimates the expected term of all options based on previous history of exercises. The risk-free rate is based on the U.S. Treasury yield curve in effect at the time of grant for the expected term of the option. The expected dividend yield is 0% as Intrexon does not expect to declare cash dividends in the near future. The fair value of the underlying common stock is determined based on the quoted market price on the New York Stock Exchange. Forfeitures are recorded when incurred. The assumptions used in the Black-Scholes option pricing model for the years ended December 31, 2017 , 2016 and 2015 are set forth in the table below: 2017 2016 2015 Valuation assumptions Expected dividend yield 0% 0% 0% Expected volatility 57%—60% 59%—60% 59%—62% Expected term (years) 6.25 6.25 6.25 Risk-free interest rate 1.89%—2.27% 1.23%—2.17% 1.56%—1.95% |
Net Loss per Share | Net Loss per Share Basic net loss per share is calculated by dividing net loss attributable to common shareholders by the weighted average shares outstanding during the period, without consideration of common stock equivalents. Diluted net loss per share is calculated by adjusting weighted average shares outstanding for the dilutive effect of common stock equivalents outstanding for the period, using the treasury-stock method. For purposes of the diluted net loss per share calculation, stock options and warrants are considered to be common stock equivalents but are excluded from the calculation of diluted net loss per share because their effect would be anti-dilutive and, therefore, basic and diluted net loss per share were the same for all periods presented. |
Segment Information | Segment Information While the Company generates revenues from multiple sources, including collaboration agreements, licensing, and products and services primarily associated with bovine reproduction, management is organized around a singular research and development focus to further the development of the Company's underlying synthetic biology technologies. Accordingly, the Company has determined that it operates in one segment. |
Use of Estimates | Use of Estimates The preparation of financial statements in conformity with U.S. GAAP requires management to make estimates and assumptions that affect the reported amounts of assets and liabilities, the disclosure of contingent assets and liabilities at the date of the financial statements, and the reported amounts of revenues and expenses during the reporting periods. Actual results could differ from those estimates. |
Recently Adopted and Issued Accounting Pronouncements | Recently Adopted Accounting Pronouncements In January 2017, the Financial Accounting Standards Board ("FASB") issued Accounting Standards Update ("ASU") 2017-04, Intangibles-Goodwill and Other (Topic 350): Simplifying the Test for Goodwill Impairment ("ASU 2017-04"). The provisions of ASU 2017-04 simplify how an entity is required to test goodwill for impairment by eliminating Step 2 from the goodwill impairment test. The Company elected to early adopt this standard in the fourth quarter of 2017 and utilized the guidance for the annual goodwill impairment test (Note 11 ). In January 2017, the FASB issued ASU 2017-01, Business Combinations (Topic 805) - Clarifying the Definition of a Business ("ASU 2017-01"). The provisions of ASU 2017-01 clarify the definition of a business to assist entities with evaluating whether transactions should be accounted for as acquisitions (or disposals) of assets or businesses. The Company adopted this standard in the second quarter of 2017, and the implementation of this standard did not have a material impact on the Company's consolidated financial statements. In October 2016, the FASB issued ASU 2016-17, Consolidation (Topic 810) - Interests Held through Related Parties That Are under Common Control ("ASU 2016-17"). The provisions of ASU 2016-17 amend the consolidation guidance on how a reporting entity that is the single decision maker of a VIE should treat indirect interests in the entity held through related parties that are under common control with the reporting entity when determining whether it is the primary beneficiary of that VIE. The Company adopted this standard effective January 1, 2017, and the implementation of this standard did not have a material impact on the Company's consolidated financial statements. In March 2016, the FASB issued ASU 2016-09, Stock Compensation (Topic 718) - Improvements to Employee Share-Based Payment Accounting ("ASU 2016-09"). The provisions of ASU 2016-09 simplify various aspects of the accounting for employee share-based payment transactions, including the income tax consequences, classification of awards as either equity or liabilities, and classification on the statement of cash flows. The Company adopted this standard effective January 1, 2017. Upon adoption in the first quarter of 2017, the Company elected to recognize forfeitures as they occur and recorded an opening adjustment to additional paid-in capital and accumulated deficit for previously unrecognized stock-based compensation costs due to estimating forfeitures on unvested shares totaling $1,461 . The Company also recognized deferred tax assets of $17,843 related to the excess tax benefits that previously arose directly from tax deductions related to equity compensation greater than stock-based compensation costs recognized in the consolidated financial statements and the cumulative adjustment for forfeitures. These deferred tax assets were fully offset by a valuation allowance (Note 13 ). The adoption was on a modified retrospective basis and had no impact on prior periods. In March 2016, the FASB issued ASU 2016-07, Investments-Equity Method and Joint Ventures (Topic 323) - Simplifying the Transition to the Equity Method of Accounting ("ASU 2016-07"). The provisions of ASU 2016-07 eliminate the requirement that when an investment qualifies for use of the equity method as a result of an increase in the level of ownership interest or degree of influence, an adjustment must be made to the investment, results of operations, and retained earnings retroactively on a step-by-step basis as if the equity method had been in effect during all previous periods that the investment had been held. The Company adopted this standard effective January 1, 2017, and the implementation of this standard did not have a material impact on the Company's consolidated financial statements. In July 2015, the FASB issued ASU 2015-11, Inventory (Topic 330) - Simplifying the Measurement of Inventory ("ASU 2015-11"). The provisions of ASU 2015-11 provide guidance for simplifying the calculation for subsequent measurement of inventory measured using the first-in-first-out or average cost methods. The Company adopted this standard effective January 1, 2017, and the implementation of this standard did not have a material impact on the Company's consolidated financial statements. Recently Issued Accounting Pronouncements In May 2014, the FASB issued ASU 2014-09, Revenue from Contracts with Customers ("ASU 2014-09"). The FASB issued ASU 2014-09 to clarify the principles for recognizing revenue and to develop a common revenue standard for U.S. GAAP. The standard outlines a single comprehensive model for entities to use in accounting for revenue arising from contracts with customers and supersedes the most current revenue recognition guidance. This guidance was originally effective for annual periods and interim periods within those annual periods beginning after December 15, 2016 and early adoption was not permitted. In August 2015, the FASB issued ASU 2015-14, Revenue from Contracts with Customers (Topic 606) - Deferral of the Effective Date , which deferred the effective date of the guidance in ASU 2014-09 by one year to December 15, 2017 for interim and annual reporting periods beginning after that date, and is effective for the Company for the year ending December 31, 2018. In 2016 and 2017, the FASB clarified the implementation guidance on principal versus agent, identifying performance obligations, licensing, narrow-scope improvements, practical expedients, and to expedite improvements to ASU 2014-09 by issuing ASU 2016-08, Revenue from Contracts with Customers (Topic 606) - Principal versus Agent Considerations , ASU 2016-10, Revenue from Contracts with Customers (Topic 606) - Identifying Performance Obligations and Licensing , and ASU 2016-12, Revenue from Contracts with Customers (Topic 606) - Narrow-Scope Improvements and Practical Expedients , ASU 2016-20, Technical Corrections and Improvements to Topic 606, Revenue from Contracts with Customers , and ASU 2017-13, Revenue Recognition (Topic 605), Revenue from Contracts with Customers (Topic 606), Leases (Topic 840), and Leases (Topic 842) . The Company continues to progress in the evaluation of its collaborations and licensing agreements and product and service revenue arrangements to determine the impact, if any, that the implementation of this standard will have on the Company's consolidated financial statements. The Company completed its review of collaboration and licensing agreements and product and service revenue arrangements and determined that other than the cumulative catch-up adjustment and related increased deferred revenue discussed below the standard will not have a significant impact on its financial position, results of operations and disclosures for these revenue arrangements. Upon adoption using the modified retrospective approach in the first quarter of 2018, the Company expects to recognize a cumulative catch-up adjustment to increase deferred revenue and accumulated deficit in the net amount of $40,413 . Under the current guidance, the Company recorded the upfront payment received from Ares Trading S.A. ("Ares Trading") net of the required payment made to ZIOPHARM as deferred revenue and is recognizing the deferred revenue over the estimated recognition period (Note 5 ). The new guidance requires gross presentation for these payments and would have resulted in the Company recording the full amount of the upfront payment received from Ares Trading as deferred revenue, recognizing the deferred revenue over the estimated recognition period, and immediately expensing the payment made to ZIOPHARM. As a result of this change under the new guidance, the Company expects to record $40,789 of additional deferred revenue relating to the additional unrecognized portion of the upfront payment, which will be recognized over the remainder of the expected recognition period. Additionally, the Company expects to reduce deferred revenue by $376 as a portion of the Company's previously deferred revenue related to a milestone payment received from ZIOPHARM pursuant to an ECC (Note 5 ) would have been recognized immediately under the new guidance. The milestone payment was received by the Company in form of the ZIOPHARM's common stock and under current guidance was valued on the date the milestone was achieved. Under the new guidance, the milestone would have been valued at contract inception with any difference in the value between contract inception and milestone achievement recorded as a gain or loss on the equity securities. Any revenue arrangements entered into subsequent to December 31, 2017 with financial or other significant terms which differ from the financial or other significant terms of the Company's existing revenue arrangements will be evaluated under this new standard. In February 2018, the FASB issued ASU 2018-02, Income Statement-Reporting Comprehensive Income (Topic 220): Reclassification of Certain Tax Effects from Accumulated Other Comprehensive Income ("ASU 2018-02"). The provisions of ASU 2018-02 allow a reclassification from accumulated other comprehensive income to retained earnings for stranded tax effects resulting from the Tax Act. The guidance is effective for annual periods and interim periods within those annual periods beginning after December 15, 2018, with early adoption permitted, and is effective for the Company for the year ending December 31, 2019. The amendments in ASU 2018-02 may be applied either in the period of adoption or retrospectively to each period (or periods) in which the effect of the change in the U.S. federal corporate income tax rate in the Tax Act is recognized. The Company is currently evaluating the impact that the implementation of this standard will have on the Company's consolidated financial statements. In July 2017, the FASB issued ASU 2017-11, Earnings Per Share (Topic 260), Distinguishing Liabilities from Equity (Topic 480) and Derivatives and Hedging (Topic 815): I. Accounting for Certain Financial Instruments with Down Round Features; II. Replacement of the Indefinite Deferral for Mandatorily Redeemable Financial Instruments of Certain Nonpublic Entities and Certain Mandatorily Redeemable Noncontrolling Interests with a Scope Exception ("ASU 2017-11"). The amendments in Part I of ASU 2017-11 change the classification analysis of certain equity-linked financial instruments (or embedded features) with down round features. When determining whether certain financial instruments should be classified as liabilities or equity instruments, a down round feature no longer precludes equity classification when assessing whether the instrument is indexed to an entity's own stock. The amendments also clarify existing disclosure requirements for equity-classified instruments. As a result, a freestanding equity-linked financial instrument (or embedded conversion option) no longer would be accounted for as a derivative liability at fair value as a result of the existence of a down round feature. For freestanding equity-classified financial instruments, the amendments require entities that present earnings per share ("EPS") in accordance with Topic 260 to recognize the effect of the down round feature when it is triggered. That effect is treated as a dividend and as a reduction of income available to common shareholders in basic EPS. Convertible instruments with embedded conversion options that have down round features are now subject to the specialized guidance for contingent beneficial conversion features (in Subtopic 470-20, Debt-Debt with Conversion and Other Options ), including related EPS guidance (in Topic 260). The amendments in Part II of ASU 2017-11 re-characterize the indefinite deferral of certain provisions of Topic 480 that now are presented as pending content in the FASB codification, to a scope exception. Those amendments do not have an accounting effect. The guidance is effective for annual periods and interim periods within those annual periods beginning after December 15, 2018, with early adoption permitted, and is effective for the Company for the year ended December 31, 2019. The Company is currently evaluating the impact that the implementation of this standard will have on the Company's consolidated financial statements. In May 2017, the FASB issued ASU 2017-09, Compensation-Stock Compensation (Topic 718) – Scope of Modification Accounting ("ASU 2017-09") . The provisions of ASU 2017-09 provide guidance about which changes to the terms or conditions of a share-based payment award require an entity to apply modification accounting in Topic 718. An entity should account for the effects of a modification unless (a) the fair value of the modified award is the same as the fair value of the original award, (b) the vesting conditions of the modified award are the same as the vesting conditions of the original award and (c) the classification of the modified award as an equity instrument or a liability instrument is the same as the classification of the original award immediately before the original award is modified. The guidance is effective for annual periods and interim periods within those annual periods beginning after December 15, 2017, and is effective for the Company for the year ending December 31, 2018. The amendments in ASU 2017-09 should be applied prospectively to an award modified on or after the adoption date. As this standard is prospective in nature, the impact to the Company's consolidated financial statements will depend on the nature of any future award modifications. In November 2016, the FASB issued ASU 2016-18, Statement of Cash Flows (Topic 230) - Restricted Cash (A Consensus of the FASB Emerging Issues Task Force) ("ASU 2016-18"). The provisions of ASU 2016-18 require amounts generally described as restricted cash and restricted cash equivalents to be included with cash and cash equivalents when reconciling the total beginning and ending balances for the periods presented on the statement of cash flows. The guidance is effective for annual periods and interim periods within those annual periods beginning after December 15, 2017, and is effective for the Company for the year ending December 31, 2018. The impact of the implementation of this standard will modify the Company's current disclosures and reclassifications within the consolidated statement of cash flows. In October 2016, the FASB issued ASU 2016-16, Income Taxes (Topic 740) - Intra-Entity Transfers of Assets Other Than Inventory ("ASU 2016-16"). The provisions of ASU 2016-16 remove the prohibition in ASC 740 against the immediate recognition of the current and deferred income tax effects of intra-entity transfers of assets other than inventory. The guidance is effective for annual periods and interim periods within those annual periods beginning after December 15, 2017, and is effective for the Company for the year ending December 31, 2018. The implementation of this standard is not expected to have a material impact on the Company's consolidated financial statements. In August 2016, the FASB issued ASU 2016-15, Statement of Cash Flows (Topic 230) - Classification of Certain Cash Receipts and Cash Payments ("ASU 2016-15"). The provisions of ASU 2016-15 address eight specific cash flow issues and how those certain cash receipts and cash payments are presented and classified in the statement of cash flows under Topic 230, Statement of Cash Flows , and other Topics. The guidance is effective for annual periods and interim periods within those annual periods beginning after December 15, 2017, and is effective for the Company for the year ending December 31, 2018. The implementation of this standard is not expected to have a material impact on the Company's consolidated financial statements. In February 2016, the FASB issued ASU 2016-02, Leases (Topic 842) ("ASU 2016-02"). The provisions of ASU 2016-02 set out the principles for the recognition, measurement, presentation and disclosure of leases for both parties to a contract (i.e. lessees and lessors). The new standard requires lessees to apply a dual approach, classifying leases as either finance or operating leases based on the principle of whether or not the lease is effectively a financed purchase by the lessee. This classification will determine whether lease expense is recognized based on an effective interest method or on a straight-line basis over the term of the lease, respectively. A lessee is also required to record a right-of-use asset and a lease liability for all leases with a term of greater than 12 months regardless of their classification. Leases with a term of 12 months or less will be accounted for in a similar manner as under existing guidance for operating leases today. ASU 2016-02 supersedes the previous lease standard, Topic 840, Leases . The guidance is effective for annual periods and interim periods within those annual periods beginning after December 15, 2018, and is effective for the Company for the year ending December 31, 2019. The Company is currently evaluating its lease agreements to determine the impact that the implementation of this standard will have on the Company's consolidated financial statements as it relates to the classification of leases under the dual approach and the recognition of a right-of-use asset and a lease liability. In January 2016, the FASB issued ASU 2016-01, Financial Instruments - Overall (Subtopic 825-10) - Recognition and Measurement of Financial Assets and Financial Liabilities ("ASU 2016-01"). The provisions of ASU 2016-01 make targeted improvements to enhance the reporting model for financial instruments to provide users of financial statements with more decision-useful information, including certain aspects of recognition, measurement, presentation, and disclosure of financial instruments. The guidance is effective for annual periods and interim periods within those annual periods beginning after December 15, 2017, and is effective for the Company for the year ending December 31, 2018. The implementation of this standard is not expected to have a material impact on the Company's consolidated financial statements. |
Reclassifications | Reclassifications Certain insignificant reclassifications have been made to the prior year consolidated financial statements to conform to the current year presentation. |
Summary of Significant Accoun32
Summary of Significant Accounting Policies (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Accounting Policies [Abstract] | |
Summarized Financial Information of Equity Method Investments | Summarized financial data as of December 31, 2017 and 2016 , and for the years ended December 31, 2017 , 2016 , and 2015 , for the Company's equity method investments for which separate financial statements are not included, pursuant to SEC Regulation S-X Article 3-09, are shown in the following tables. December 31, 2017 2016 Current assets $ 61,086 $ 77,761 Non-current assets 13,598 11,040 Total assets 74,684 88,801 Current liabilities 6,213 11,588 Net assets $ 68,471 $ 77,213 Year Ended December 31, 2017 2016 2015 Revenues, net $ 254 $ 417 $ 1,176 Operating expenses 41,904 62,373 32,513 Operating loss (41,650 ) (61,956 ) (31,337 ) Other, net (8 ) 1,535 (64 ) Net loss $ (41,658 ) $ (60,421 ) $ (31,401 ) |
Rollforward of Allowance for Doubtful Receivable Accounts | The following table shows the activity in the allowance for doubtful receivable accounts for the years ended December 31, 2017 , 2016 , and 2015 : 2017 2016 2015 Beginning balance $ 3,703 $ 2,081 $ 565 Charged to operating expenses 1,217 1,963 1,757 Write offs of accounts receivable, net of recoveries (289 ) (341 ) (241 ) Ending balance $ 4,631 $ 3,703 $ 2,081 |
Estimated Useful Lives of Property, Plant and Equipment | The estimated useful lives of these assets are as follows: Years Land improvements 4–20 Buildings and building improvements 3–25 Furniture and fixtures 1–10 Equipment 1–10 Breeding stock 1–4 Computer hardware and software 1–7 Leasehold improvements are amortized over the shorter of the useful life of the asset or the applicable lease term, generally one to twenty years . |
Summary of Assumptions Used in Option Pricing Model | The assumptions used in the Black-Scholes option pricing model for the years ended December 31, 2017 , 2016 and 2015 are set forth in the table below: 2017 2016 2015 Valuation assumptions Expected dividend yield 0% 0% 0% Expected volatility 57%—60% 59%—60% 59%—62% Expected term (years) 6.25 6.25 6.25 Risk-free interest rate 1.89%—2.27% 1.23%—2.17% 1.56%—1.95% |
Mergers and Acquisitions (Table
Mergers and Acquisitions (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
GenVec, Inc. | |
Business Acquisition [Line Items] | |
Fair Value of Consideration Transferred | The fair value of the total consideration transferred was $17,582 . The acquisition date fair value of each class of consideration transferred is presented below: Common shares $ 15,616 Warrants 1,381 Contingent consideration 585 $ 17,582 |
Fair Value of Assets Acquired and Liabilities Assumed | The estimated fair value of assets acquired and liabilities assumed at the acquisition date is shown below: Cash and cash equivalents $ 2,054 Short term investments 542 Trade receivables 75 Other receivables 97 Prepaid expenses and other 227 Property and equipment 250 Intangible assets 14,000 Other noncurrent assets 58 Total assets acquired 17,303 Accounts payable 2,158 Accrued compensation and benefits 1,226 Other accrued expenses 856 Other long term liabilities 92 Deferred tax liabilities 239 Total liabilities assumed 4,571 Net assets acquired 12,732 Goodwill 4,850 Total consideration $ 17,582 |
Condensed Pro forma Financial Information | The following unaudited condensed pro forma financial information for the years ended December 31, 2017 and 2016, is presented as if the acquisition had been consummated on January 1, 2016: Year Ended December 31, 2017 2016 Pro Forma Revenues $ 231,213 $ 191,437 Loss before income taxes (136,966 ) (201,210 ) Net loss (134,275 ) (197,144 ) Net loss attributable to the noncontrolling interests 9,802 3,662 Net loss attributable to Intrexon (124,473 ) (193,482 ) |
Oxitec Limited | |
Business Acquisition [Line Items] | |
Fair Value of Consideration Transferred | The fair value of the total consideration transferred was $ 146,394 . The acquisition date fair value of the Stock Consideration and Cash Consideration is presented below: Cash $ 90,199 Common shares 56,195 $ 146,394 |
Fair Value of Assets Acquired and Liabilities Assumed | The estimated fair value of assets acquired and liabilities assumed at the acquisition date is shown below: Cash $ 3,780 Trade receivables 125 Other receivables 7,395 Prepaid expenses and other 121 Property, plant, and equipment 1,198 Intangible assets 96,854 Total assets acquired 109,473 Accounts payable 1,187 Accrued compensation and benefits 246 Other accrued liabilities 210 Deferred revenue 120 Deferred tax liabilities 12,584 Total liabilities assumed 14,347 Net assets acquired 95,126 Goodwill 51,268 Total consideration $ 146,394 |
Okanagan Specialty Fruits Inc. | |
Business Acquisition [Line Items] | |
Fair Value of Consideration Transferred | The fair value of the total consideration transferred was $40,933 . The acquisition date fair value of each class of consideration transferred is presented below: Cash $ 10,000 Common shares 30,933 $ 40,933 |
Fair Value of Assets Acquired and Liabilities Assumed | The estimated fair value of assets acquired and liabilities assumed at the acquisition date is shown below: Cash $ 58 Trade receivables 16 Other receivables 49 Property, plant, and equipment 32 Intangible assets 36,500 Total assets acquired 36,655 Accounts payable 181 Deferred revenue 181 Deferred tax liabilities 8,847 Total liabilities assumed 9,209 Net assets acquired 27,446 Goodwill 13,487 Total consideration $ 40,933 |
ActoGeniX NV | |
Business Acquisition [Line Items] | |
Fair Value of Consideration Transferred | The fair value of the total consideration transferred was $ 72,474 . The acquisition date fair value of each class of consideration transferred is presented below: Cash $ 32,739 Common shares 39,735 $ 72,474 |
Fair Value of Assets Acquired and Liabilities Assumed | The estimated fair value of assets acquired and liabilities assumed at the acquisition date is shown below: Cash $ 3,180 Other receivables 305 Prepaid expenses and other 31 Property, plant and equipment 209 Intangible assets 68,100 Other noncurrent assets 23 Total assets acquired 71,848 Accounts payable 230 Accrued compensation and benefits 196 Other accrued liabilities 253 Deferred revenue 732 Deferred tax liabilities 612 Total liabilities assumed 2,023 Net assets acquired 69,825 Goodwill 2,649 Total consideration $ 72,474 |
2015 Business Acquisitions | |
Business Acquisition [Line Items] | |
Condensed Pro forma Financial Information | The following unaudited condensed pro forma financial information for the year ended December 31, 2015 is presented as if the 2015 acquisitions had been consummated on January 1, 2014: Year Ended December 31, 2015 Pro Forma Revenues $ 174,558 Loss before income taxes (99,751 ) Net loss (99,594 ) Net loss attributable to the noncontrolling interests 3,501 Net loss attributable to Intrexon (96,093 ) |
Collaboration and Licensing R34
Collaboration and Licensing Revenue (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Organization, Consolidation and Presentation of Financial Statements [Abstract] | |
Summarized Collaboration and Licensing Revenues | The following tables summarize the amounts recorded as revenue in the consolidated statements of operations for each significant collaboration or licensing agreement for the years ended December 31, 2017 , 2016 and 2015 . Year Ended December 31, 2017 Revenue Recognized From Total Upfront and Milestone Payments Research and Development Services ZIOPHARM Oncology, Inc. $ 48,313 $ 21,499 $ 69,812 Oragenics, Inc. 1,047 973 2,020 Fibrocell Science, Inc. 2,419 4,925 7,344 Genopaver, LLC 273 6,417 6,690 S & I Ophthalmic, LLC — 755 755 OvaXon, LLC — 1,966 1,966 Intrexon Energy Partners, LLC 2,500 8,165 10,665 Persea Bio, LLC 500 446 946 Ares Trading S.A. 6,389 4,349 10,738 Intrexon Energy Partners II, LLC 2,000 1,672 3,672 Intrexon T1D Partners, LLC 1,109 4,859 5,968 Harvest start-up entities (1) 2,442 12,790 15,232 Other 4,645 5,126 9,771 Total $ 71,637 $ 73,942 $ 145,579 (1) For the year ended December 31, 2017 , revenue recognized from collaborations with Harvest start-up entities include Thrive Agrobiotics, Inc.; Exotech Bio, Inc.; Relieve Genetics, Inc.; AD Skincare, Inc.; Genten Therapeutics, Inc.; and CRS Bio, Inc. Year Ended December 31, 2016 Revenue Recognized From Total Upfront and Milestone Payments Research and Development Services ZIOPHARM Oncology, Inc. $ 11,529 $ 22,307 $ 33,836 Oragenics, Inc. 1,047 1,705 2,752 Fibrocell Science, Inc. 2,419 3,523 5,942 Genopaver, LLC 273 5,844 6,117 S & I Ophthalmic, LLC — 6,141 6,141 OvaXon, LLC — 2,934 2,934 Intrexon Energy Partners, LLC 2,500 15,052 17,552 Persea Bio, LLC 500 778 1,278 Ares Trading S.A. 6,389 3,803 10,192 Intrexon Energy Partners II, LLC 2,000 1,169 3,169 Intrexon T1D Partners, LLC 821 1,087 1,908 Harvest start-up entities (1) 1,383 3,591 4,974 Other 5,572 7,504 13,076 Total $ 34,433 $ 75,438 $ 109,871 (1) For the year ended December 31, 2016 , revenue recognized from collaborations with Harvest start-up entities include Thrive Agrobiotics, Inc.; Exotech Bio, Inc.; Relieve Genetics, Inc.; AD Skincare, Inc.; Genten Therapeutics, Inc.; and CRS Bio, Inc. Year Ended December 31, 2015 Revenue Recognized From Total Upfront and Milestone Payments Research and Development Services ZIOPHARM Oncology, Inc. $ 2,855 $ 16,451 $ 19,306 Oragenics, Inc. 5,679 856 6,535 Fibrocell Science, Inc. 6,046 6,133 12,179 Genopaver, LLC 273 3,556 3,829 S & I Ophthalmic, LLC — 4,115 4,115 OvaXon, LLC — 2,540 2,540 Intrexon Energy Partners, LLC 2,500 10,947 13,447 Persea Bio, LLC 500 741 1,241 Ares Trading S.A. 3,933 795 4,728 Intrexon Energy Partners II, LLC 167 — 167 Harvest start-up entities (1) 46 220 266 Other 10,514 8,954 19,468 Total $ 32,513 $ 55,308 $ 87,821 (1) For the year ended December 31, 2015 , revenue recognized from collaborations with Harvest start-up entities include Thrive Agrobiotics, Inc. |
Summary of Deferred Revenue | Deferred revenue consists of the following: December 31, 2017 2016 Upfront and milestone payments $ 230,531 $ 297,867 Prepaid research and development services 1,052 6,015 Prepaid product and service revenues 4,681 5,554 Other 133 706 Total $ 236,397 $ 310,142 Current portion of deferred revenue $ 42,870 $ 53,364 Long-term portion of deferred revenue 193,527 256,778 Total $ 236,397 $ 310,142 |
Summary of Deferred Revenue by Collaborator | The following table summarizes the remaining balance of deferred revenue associated with upfront and milestone payments for each significant collaboration and licensing agreement. December 31, 2017 2016 ZIOPHARM Oncology, Inc. $ 90,496 $ 138,809 Oragenics, Inc. 6,719 7,766 Fibrocell Science, Inc. 16,607 19,026 Genopaver, LLC 1,704 1,977 Intrexon Energy Partners, LLC 15,625 18,125 Persea Bio, LLC 3,500 4,000 Ares Trading S.A. 40,789 47,178 Intrexon Energy Partners II, LLC 13,833 15,833 Intrexon T1D Partners, LLC 8,435 8,653 Harvest start-up entities (1) 18,400 20,208 Other 14,423 16,292 Total $ 230,531 $ 297,867 (1) As of December 31, 2017 and December 31, 2016 , the balance of deferred revenue for collaborations with Harvest start-up entities includes Thrive Agrobiotics, Inc.; Exotech Bio, Inc.; Relieve Genetics, Inc.; AD Skincare, Inc.; Genten Therapeutics, Inc.; and CRS Bio, Inc. |
Short-term and Long-term Inve35
Short-term and Long-term Investments (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Investments, Debt and Equity Securities [Abstract] | |
Summary of Amortized Cost, Gross Unrealized Gains and Losses and Fair Value of Investments | The following table summarizes the amortized cost, gross unrealized gains and losses and fair value of available-for-sale investments as of December 31, 2017 : Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Aggregate Fair Value U.S. government debt securities $ 6,000 $ — $ (2 ) $ 5,998 Certificates of deposit 275 — — 275 Total $ 6,275 $ — $ (2 ) $ 6,273 The following table summarizes the amortized cost, gross unrealized gains and losses and fair value of available-for-sale investments as of December 31, 2016 : Amortized Cost Gross Unrealized Gains Gross Unrealized Losses Aggregate Fair Value U.S. government debt securities $ 180,412 $ 5 $ (94 ) $ 180,323 Certificates of deposit 272 — — 272 Total $ 180,684 $ 5 $ (94 ) $ 180,595 |
Investments in Preferred Stock
Investments in Preferred Stock (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Investment in Preferred Stock [Abstract] | |
Schedule of Changes in Level 3 Investments | The following table summarizes the changes in the Level 3 investments in preferred stock during the years ended December 31, 2017 and 2016 . 2017 2016 Beginning balance $ 129,545 $ — Receipt of preferred stock as consideration for amendments to collaboration agreements — 120,000 Purchase of preferred stock 766 — Conversion of receivables to preferred stock 3,385 — Dividend income from investments in preferred stock 16,756 7,421 Net unrealized appreciation in the fair value of the investments in preferred stock 10,773 2,124 Ending balance $ 161,225 $ 129,545 |
Fair Value Measurements (Tables
Fair Value Measurements (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Fair Value Disclosures [Abstract] | |
Summary of Placement in the Fair Value Hierarchy of Financial Assets that are Measured at Fair Value on a Recurring Basis | The following table presents the placement in the fair value hierarchy of financial assets that are measured at fair value on a recurring basis, including the items for which the fair value option has been elected, as of December 31, 2017 : Quoted Prices in Active Markets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) December 31, Assets U.S. government debt securities $ — $ 5,998 $ — $ 5,998 Equity securities 10,537 4,563 — 15,100 Preferred stock — — 161,225 161,225 Other — 850 — 850 Total $ 10,537 $ 11,411 $ 161,225 $ 183,173 The following table presents the placement in the fair value hierarchy of financial assets that are measured at fair value on a recurring basis, including the items for which the fair value option has been elected, as of December 31, 2016 : Quoted Prices in Active Markets (Level 1) Significant Other Observable Inputs (Level 2) Significant Unobservable Inputs (Level 3) December 31, Assets U.S. government debt securities $ — $ 180,323 $ — $ 180,323 Equity securities 15,544 7,978 — 23,522 Preferred stock — — 129,545 129,545 Other — 1,917 — 1,917 Total $ 15,544 $ 190,218 $ 129,545 $ 335,307 |
Schedule of Changes in Level 3 Liabilities | The changes in the fair value of the Level 3 liabilities during the years ended December 31, 2017 and 2016 were as follows: 2017 2016 Beginning balance $ 2,081 $ — Acquisition date fair value of contingent consideration liability 585 3,660 Payment of contingent consideration (Note 4) — (1,583 ) Change in fair value of contingent consideration recognized in selling, general and administrative expenses (2,081 ) 4 Ending balance $ 585 $ 2,081 |
Inventory (Tables)
Inventory (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Inventory Disclosure [Abstract] | |
Schedule of Inventory | Inventory consists of the following: December 31, 2017 2016 Supplies, embryos and other production materials $ 2,673 $ 1,835 Work in process 4,767 5,466 Livestock 11,040 11,752 Feed 2,013 2,086 Total inventory $ 20,493 $ 21,139 |
Property, Plant and Equipment39
Property, Plant and Equipment, Net (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Property, Plant and Equipment [Abstract] | |
Schedule of Property, Plant and Equipment | Property, plant and equipment consist of the following: December 31, 2017 2016 Land and land improvements $ 11,767 $ 10,904 Buildings and building improvements 18,183 8,123 Furniture and fixtures 2,515 2,176 Equipment 65,863 44,392 Leasehold improvements 25,277 15,105 Breeding stock 3,832 3,893 Computer hardware and software 10,128 6,844 Trees 6,642 2,772 Construction and other assets in progress 14,113 4,513 158,320 98,722 Less: Accumulated depreciation and amortization (45,646 ) (34,050 ) Property, plant and equipment, net $ 112,674 $ 64,672 |
Goodwill and Intangible Asset40
Goodwill and Intangible Assets, Net (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Goodwill and Intangible Assets Disclosure [Abstract] | |
Schedule of Changes in Carrying Amount of Goodwill | The changes in the carrying amount of goodwill for the years ended December 31, 2017 and 2016 , are as follows: 2017 2016 Beginning balance $ 157,175 $ 165,169 Acquisitions 4,850 — Impairment (13,823 ) — Foreign currency translation adjustments 5,087 (7,994 ) Ending balance $ 153,289 $ 157,175 |
Schedule of Intangible Assets | Intangible assets consist of the following as of December 31, 2017 : Weighted Average Useful Life (Years) Gross Carrying Amount Accumulated Amortization Net Patents, developed technologies and know-how 15.9 $ 263,615 $ (44,954 ) $ 218,661 Customer relationships 6.5 10,700 (6,383 ) 4,317 Trademarks 9.3 6,800 (2,567 ) 4,233 In-process research and development 5,666 — 5,666 Total $ 286,781 $ (53,904 ) $ 232,877 Intangible assets consist of the following as of December 31, 2016 : Gross Carrying Amount Accumulated Amortization Net Patents, developed technologies and know-how $ 236,401 $ (29,748 ) $ 206,653 Customer relationships 10,700 (4,672 ) 6,028 Trademarks 6,800 (1,792 ) 5,008 Covenant not to compete 370 (339 ) 31 In-process research and development 7,895 — 7,895 Total $ 262,166 $ (36,551 ) $ 225,615 |
Schedule of Definite-Lived Intangible Assets, Estimated Future Amortization Expense | Estimated aggregate amortization expense for definite lived intangible assets is expected to be as follows: 2018 $ 19,258 2019 18,935 2020 18,833 2021 18,645 2022 17,646 Thereafter 133,894 Total $ 227,211 |
Lines of Credit and Long Term41
Lines of Credit and Long Term Debt (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Debt Disclosure [Abstract] | |
Schedule of Long Term Debt Instruments | Long term debt consists of the following: December 31, 2017 2016 Notes payable $ 5,010 $ 5,453 Royalty-based financing 2,132 1,896 Other 895 599 Long term debt 8,037 7,948 Less current portion 502 386 Long term debt, less current portion $ 7,535 $ 7,562 |
Schedule of Maturities of Long Term Debt | Future maturities of long term debt are as follows: 2018 $ 502 2019 401 2020 372 2021 832 2022 360 Thereafter 3,438 Total $ 5,905 |
Income Taxes (Tables)
Income Taxes (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Income Tax Disclosure [Abstract] | |
Components of Loss Before Income Taxes | The components of loss before income taxes are presented below: Year Ended December 31, 2017 2016 2015 Domestic $ (71,343 ) $ (157,067 ) $ (69,287 ) Foreign (58,357 ) (37,084 ) (17,691 ) Loss before income taxes $ (129,700 ) $ (194,151 ) $ (86,978 ) |
Components of Income Tax Expense (Benefit) | The components of income tax expense (benefit) are presented below: Year Ended December 31, 2017 2016 2015 U.S. federal income taxes: Current $ 27 $ (17 ) $ 22 Deferred (523 ) 1,396 1,732 Foreign income taxes: Current (379 ) (393 ) (123 ) Deferred (2,269 ) (5,177 ) (1,003 ) State income taxes: Deferred 264 314 388 Income tax expense (benefit) $ (2,880 ) $ (3,877 ) $ 1,016 |
Schedule of Effective Income Tax Rate Reconciliation | Income tax expense (benefit) for the years ended December 31, 2017 , 2016 and 2015 differed from amounts computed by applying the applicable U.S. federal corporate income tax rate of 34% to loss before income taxes as a result of the following: 2017 2016 2015 Computed statutory income tax benefit $ (44,098 ) $ (66,011 ) $ (29,573 ) State and provincial income tax benefit, net of federal income taxes (3,294 ) (7,905 ) (3,157 ) Nondeductible stock based compensation 4,147 3,321 3,182 Nondeductible officer compensation 476 — 2,433 Gain on dividend distribution of AquaBounty common stock 3,965 — — Impairment of goodwill 4,700 — — Research and development tax incentives (1,166 ) (6,350 ) (348 ) Acquisition and internal restructuring transaction costs 354 571 883 Provisional impact of the Tax Act 85,288 — — Enacted changes in foreign tax rates and foreign tax reforms 2,138 — (961 ) U.S.-foreign rate differential 5,410 3,463 620 Other, net (64 ) 1,485 (98 ) 57,856 (71,426 ) (27,019 ) Change in valuation allowance for deferred tax assets (60,736 ) 67,549 28,035 Total income tax expense (benefit) $ (2,880 ) $ (3,877 ) $ 1,016 |
Schedule of Deferred Tax Assets and Liabilities | The tax effects of temporary differences that comprise the deferred tax assets and liabilities as of December 31, 2017 and 2016 , are as follows: 2017 2016 Deferred tax assets Allowance for doubtful accounts $ 1,300 $ 1,676 Inventory 489 447 Equity securities and investments in affiliates 17,510 31,729 Accrued liabilities and long-term debt 3,131 4,168 Stock-based compensation 26,936 8,460 Deferred revenue 61,785 68,056 Research and development tax credits 11,385 10,396 Net operating and capital loss carryforwards 111,453 144,502 Total deferred tax assets 233,989 269,434 Less: Valuation allowance 215,582 256,165 Net deferred tax assets 18,407 13,269 Deferred tax liabilities Property, plant and equipment 237 406 Intangible assets 33,790 29,870 Total deferred tax liabilities 34,027 30,276 Net deferred tax liabilities $ (15,620 ) $ (17,007 ) |
Summary of Valuation Allowance | Activity within the valuation allowance for deferred tax assets during the years ended December 31, 2017 , 2016 and 2015 was as follows: 2017 2016 2015 Valuation allowance at beginning of year $ 256,165 $ 190,174 $ 161,660 Increase (decrease) in valuation allowance as a result of Mergers and acquisitions, net — (1,416 ) 1,228 Current year operations 26,619 67,549 28,035 Adoption of ASU 2016-09 17,843 — — Provisional impact of the Tax Act (87,473 ) — — Changes in foreign tax rates and foreign tax reforms 1,327 — — Foreign currency translation adjustment 1,101 (142 ) (749 ) Valuation allowance at end of year $ 215,582 $ 256,165 $ 190,174 |
Shareholders' Equity (Tables)
Shareholders' Equity (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Equity [Abstract] | |
Schedule of Accumulated Other Comprehensive Loss | The components of accumulated other comprehensive loss are as follows: December 31, 2017 2016 Unrealized loss on investments $ (2 ) $ (89 ) Loss on foreign currency translation adjustments (15,552 ) (36,113 ) Total accumulated other comprehensive loss $ (15,554 ) $ (36,202 ) |
Share-Based Payments (Tables)
Share-Based Payments (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Disclosure of Compensation Related Costs, Share-based Payments [Abstract] | |
Schedule of Stock-based Compensation Expense | Stock-based compensation costs included in the consolidated statements of operations are presented below: Year Ended December 31, 2017 2016 2015 Cost of products $ 116 $ 81 $ 95 Cost of services 322 274 354 Research and development 9,336 9,251 8,614 Selling, general and administrative 31,802 32,596 29,604 Total $ 41,576 $ 42,202 $ 38,667 |
Schedule of Stock Option Activity | Stock option activity was as follows: Number of Shares Weighted Average Exercise Price Weighted Average Remaining Contractual Term (Years) Balances at December 31, 2014 8,323,544 $ 22.59 8.64 Granted 5,051,500 45.82 Adjustment due to dividend (Note 14) 312,795 25.40 Exercised (1,029,291 ) (15.16 ) Forfeited (1,610,335 ) (26.75 ) Expired (4,685 ) (28.29 ) Balances at December 31, 2015 11,043,528 32.66 8.49 Granted 4,644,860 29.39 Exercised (1,210,840 ) (15.83 ) Forfeited (2,760,809 ) (40.34 ) Expired (76,356 ) (37.81 ) Balances at December 31, 2016 11,640,383 31.25 8.21 Granted 3,920,950 21.47 Adjustment due to dividend (Note 14) 46,766 31.11 Exercised (149,429 ) (6.37 ) Forfeited (3,797,105 ) (28.37 ) Expired (278,818 ) (33.18 ) Balances at December 31, 2017 11,382,747 28.99 7.32 Exercisable at December 31, 2017 5,306,697 29.96 6.14 |
Summary of Information About Stock Options Outstanding | The following table summarizes additional information about stock options outstanding as of December 31, 2017 : Options Outstanding Options Exercisable Range of Exercise Prices Number of Options Weighted Average Exercise Price Weighted Average Remaining Life (Years) Aggregate Intrinsic Value Number of Options Weighted Average Exercise Price Weighted Average Remaining Life (Years) Aggregate Intrinsic Value $ 2.64 — $ 9.30 453,371 $ 7.06 3.94 $ 2,020 453,371 $ 7.06 3.94 $ 2,020 $ 12.50 — $ 21.38 3,158,121 20.58 8.74 — 456,942 19.52 7.13 — $ 21.43 — $ 28.81 3,399,721 25.55 6.91 — 1,804,401 25.86 5.69 — $ 28.88 — $ 40.99 2,751,716 32.07 6.70 — 1,732,250 31.51 6.32 — $ 41.41 — $ 65.08 1,619,818 53.52 7.42 — 859,733 53.07 7.38 — 11,382,747 $ 28.99 7.32 $ 2,020 5,306,697 $ 29.96 6.14 $ 2,020 The following table summarizes additional information about stock options outstanding as of December 31, 2016 : Options Outstanding Options Exercisable Range of Exercise Prices Number of Options Weighted Average Exercise Price Weighted Average Remaining Life (Years) Aggregate Intrinsic Value Number of Options Weighted Average Exercise Price Weighted Average Remaining Life (Years) Aggregate Intrinsic Value $ 2.65 — $ 9.34 562,951 $ 6.23 4.13 $ 10,172 525,755 $ 6.01 3.97 $ 9,615 $ 15.21 — $ 27.19 2,785,705 23.47 8.54 4,797 684,704 21.07 7.29 2,237 $ 27.21 — $ 29.68 3,147,242 29.30 7.53 — 1,400,707 29.35 7.31 — $ 29.70 — $ 42.22 3,590,423 32.89 9.09 — 345,274 37.06 6.85 — $ 43.99 — $ 65.34 1,554,062 54.40 8.43 — 461,595 53.06 8.33 — 11,640,383 $ 31.25 8.21 $ 14,969 3,418,035 $ 28.09 6.88 $ 11,852 |
Commitments and Contingencies (
Commitments and Contingencies (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Commitments and Contingencies Disclosure [Abstract] | |
Future Minimum Lease Payments Under Noncancelable Operating Leases | As of December 31, 2017 , future minimum lease payments under operating leases having initial or remaining noncancelable lease terms in excess of one year are as follows: 2018 $ 7,964 2019 9,115 2020 9,186 2021 8,299 2022 7,279 Thereafter 26,044 Total $ 67,887 |
Net Loss per Share (Tables)
Net Loss per Share (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Earnings Per Share [Abstract] | |
Computation of Basic and Diluted Net Loss per Share | The following table presents the computation of basic and diluted net loss per share: 2017 2016 2015 Historical net loss per share: Numerator: Net loss attributable to Intrexon $ (117,018 ) $ (186,612 ) $ (84,493 ) Denominator: Weighted average shares outstanding, basic and diluted 119,998,826 117,983,836 111,066,352 Net loss attributable to Intrexon per share, basic and diluted $ (0.98 ) $ (1.58 ) $ (0.76 ) |
Potentially Dilutive Securities Excluded from Calculation of Net Loss per Share | The following potentially dilutive securities as of December 31, 2017 , 2016 , and 2015 , have been excluded from the above computations of diluted weighted average shares outstanding for the years then ended as they would have been anti-dilutive: December 31, 2017 2016 2015 Options 11,382,747 11,640,383 11,043,528 Warrants 133,264 — 194,719 Total 11,516,011 11,640,383 11,238,247 |
Quarterly Financial Informati47
Quarterly Financial Information (Unaudited) (Tables) | 12 Months Ended |
Dec. 31, 2017 | |
Quarterly Financial Information Disclosure [Abstract] | |
Schedule of Quarterly Financial Information (Unaudited) | The following information has been derived from unaudited consolidated statements that, in the opinion of management, include all recurring adjustments necessary for a fair statement of such information. Three Months Ended March 31, June 30, September 30, December 31, 2017 (1) Total revenues $ 53,504 $ 54,433 $ 46,016 $ 77,028 Operating loss (31,381 ) (35,270 ) (44,747 ) (26,492 ) Net loss (32,377 ) (19,662 ) (40,836 ) (33,945 ) Net loss attributable to Intrexon (31,399 ) (18,664 ) (39,689 ) (27,266 ) Net loss attributable to Intrexon per share, basic and diluted $ (0.26 ) $ (0.16 ) $ (0.33 ) $ (0.23 ) Three Months Ended March 31, June 30, September 30, December 31, Total revenues $ 43,438 $ 52,501 $ 48,985 $ 46,002 Operating loss (40,533 ) (23,222 ) (28,821 ) (32,590 ) Net loss (65,320 ) (50,031 ) (30,011 ) (44,912 ) Net loss attributable to Intrexon (64,429 ) (49,064 ) (28,982 ) (44,137 ) Net loss attributable to Intrexon per share, basic and diluted $ (0.55 ) $ (0.42 ) $ (0.24 ) $ (0.37 ) (1) During the fourth quarter of 2017, the Company recognized the remaining balance of deferred revenue associated with ZIOPHARM ECC2 upon the parties' mutual agreement to terminate (Note 5 ). The Company also recorded goodwill impairment charges primarily related to the AquaBounty reporting unit and an impairment charge related to certain of its in-process research and development assets (Note 11 ). |
Organization and Basis of Pre48
Organization and Basis of Presentation - Additional Information (Details) $ in Thousands | 1 Months Ended | 12 Months Ended | |||
Mar. 31, 2017USD ($)shares | Jan. 31, 2017USD ($) | Dec. 31, 2017USD ($) | Dec. 31, 2016USD ($) | Dec. 31, 2015USD ($)shares | |
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] | |||||
Purchase of noncontrolling interest by parent, parent equity issued (in shares) | shares | 307,074 | ||||
Purchase of noncontrolling interest by parent, parent equity issued | $ 913 | $ 0 | $ 1,566 | ||
Biological & Popular Culture, Inc. | |||||
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] | |||||
Purchase of noncontrolling interest by parent, percentage | 0.49 | ||||
Purchase of noncontrolling interest by parent, cash paid | $ 900 | ||||
Purchase of noncontrolling interest by parent, parent equity issued (in shares) | shares | 221,743 | ||||
Purchase of noncontrolling interest by parent, parent equity issued | $ 5,082 | ||||
AquaBounty Technologies, Inc. | |||||
Organization, Consolidation and Presentation of Financial Statements Disclosure [Line Items] | |||||
Parent ownership interest | 58.00% | ||||
Purchase of additional equity of majority-owned subsidiary | $ 25,000 |
Summary of Significant Accoun49
Summary of Significant Accounting Policies - Additional Information (Details) $ in Thousands | 3 Months Ended | 12 Months Ended | |||||||||||
Dec. 31, 2017USD ($) | Sep. 30, 2017USD ($) | Jun. 30, 2017USD ($) | Mar. 31, 2017USD ($) | Dec. 31, 2016USD ($) | Sep. 30, 2016USD ($) | Jun. 30, 2016USD ($) | Mar. 31, 2016USD ($) | Dec. 31, 2017USD ($)segment | Dec. 31, 2016USD ($) | Dec. 31, 2015USD ($) | Jan. 01, 2018USD ($) | ||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Research and development commitments with third parties not incurred | $ 10,682 | $ 10,631 | $ 10,682 | $ 10,631 | |||||||||
Maturity period of highly liquid investment | 3 months | ||||||||||||
Cash equivalent investments in highly liquid money market accounts | 43,012 | 43,808 | $ 43,012 | 43,808 | |||||||||
Fair value of financial assets measured at fair value on a recurring basis | 183,173 | 335,307 | 183,173 | 335,307 | |||||||||
Unrealized and realized appreciation (depreciation) in fair value of equity securities and preferred stock | 2,586 | (58,894) | $ 66,876 | ||||||||||
Maximum risk of loss related to the identified VIEs | 185,261 | 159,115 | $ 185,261 | 159,115 | |||||||||
Number of segments | segment | 1 | ||||||||||||
Property, plant and equipment, net | 112,674 | 64,672 | $ 112,674 | 64,672 | |||||||||
Revenues | $ 77,028 | [1] | $ 46,016 | $ 54,433 | $ 53,504 | $ 46,002 | $ 48,985 | $ 52,501 | $ 43,438 | 230,981 | 190,926 | 173,605 | |
Cumulative effect of adoption of ASU 2016-09 | 0 | ||||||||||||
Valuation allowance, deferred tax asset, change in amount due to adoption of accounting principle | $ 17,843 | $ 0 | 0 | ||||||||||
Oragenics, Inc. | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Company's ownership percentage | 29.40% | 29.50% | 29.40% | 29.50% | |||||||||
ZIOPHARM Oncology, Inc. | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Realized investment gain | 81,401 | ||||||||||||
Equity securities | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Fair value of financial assets measured at fair value on a recurring basis | $ 15,100 | $ 23,522 | $ 15,100 | $ 23,522 | |||||||||
Equity securities | Oragenics, Inc. | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Fair value of financial assets measured at fair value on a recurring basis | 3,085 | 7,244 | 3,085 | 7,244 | |||||||||
Unrealized and realized appreciation (depreciation) in fair value of equity securities and preferred stock | (4,159) | (10,523) | 4,863 | ||||||||||
Foreign Countries | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Property, plant and equipment, net | $ 21,837 | $ 13,265 | 21,837 | 13,265 | |||||||||
Revenues | $ 17,605 | $ 11,969 | $ 5,918 | ||||||||||
Minimum | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Expected useful life of intangible asset | 3 years | ||||||||||||
Maximum | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Expected useful life of intangible asset | 21 years | ||||||||||||
Intrexon Stock Option Plans | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Expected dividend yield | 0.00% | 0.00% | 0.00% | ||||||||||
Additional Paid-in Capital | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Cumulative effect of adoption of ASU 2016-09 | $ 1,461 | ||||||||||||
Subsequent Event | Accounting Standards Update 2014-09 | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Cumulative effect of adoption of ASU 2014-09 | $ 40,413 | ||||||||||||
Subsequent Event | Ares Trading S.A. | Accounting Standards Update 2014-09 | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Cumulative effect of adoption of ASU 2014-09 | 40,789 | ||||||||||||
Subsequent Event | ZIOPHARM Oncology, Inc. | Accounting Standards Update 2014-09 | |||||||||||||
Organization And Significant Accounting Policies [Line Items] | |||||||||||||
Cumulative effect of adoption of ASU 2014-09 | $ 376 | ||||||||||||
[1] | During the fourth quarter of 2017, the Company recognized the remaining balance of deferred revenue associated with ZIOPHARM ECC2 upon the parties' mutual agreement to terminate (Note 5). The Company also recorded goodwill impairment charges primarily related to the AquaBounty reporting unit and an impairment charge related to certain of its in-process research and development assets (Note 11). |
Summary of Significant Accoun50
Summary of Significant Accounting Policies - Summarized Financial Data of Equity Method Investments (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended | ||||||||||
Dec. 31, 2017 | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | ||
Equity Method Investment, Summarized Financial Information, Gross Profit (Loss) [Abstract] | ||||||||||||
Operating expenses | $ 368,871 | $ 316,092 | $ 320,469 | |||||||||
Operating loss | $ (26,492) | [1] | $ (44,747) | $ (35,270) | $ (31,381) | $ (32,590) | $ (28,821) | $ (23,222) | $ (40,533) | (137,890) | (125,166) | (146,864) |
Other, net | 22,473 | (47,865) | 68,830 | |||||||||
Equity Method Investments | ||||||||||||
Equity Method Investment, Summarized Financial Information, Assets [Abstract] | ||||||||||||
Current assets | 61,086 | 77,761 | 61,086 | 77,761 | ||||||||
Non-current assets | 13,598 | 11,040 | 13,598 | 11,040 | ||||||||
Total assets | 74,684 | 88,801 | 74,684 | 88,801 | ||||||||
Equity Method Investment, Summarized Financial Information, Liabilities [Abstract] | ||||||||||||
Current liabilities | 6,213 | 11,588 | 6,213 | 11,588 | ||||||||
Net assets | $ 68,471 | $ 77,213 | 68,471 | 77,213 | ||||||||
Equity Method Investment, Summarized Financial Information, Gross Profit (Loss) [Abstract] | ||||||||||||
Revenues, net | 254 | 417 | 1,176 | |||||||||
Operating expenses | 41,904 | 62,373 | 32,513 | |||||||||
Operating loss | (41,650) | (61,956) | (31,337) | |||||||||
Other, net | (8) | 1,535 | (64) | |||||||||
Net loss | $ (41,658) | $ (60,421) | $ (31,401) | |||||||||
[1] | During the fourth quarter of 2017, the Company recognized the remaining balance of deferred revenue associated with ZIOPHARM ECC2 upon the parties' mutual agreement to terminate (Note 5). The Company also recorded goodwill impairment charges primarily related to the AquaBounty reporting unit and an impairment charge related to certain of its in-process research and development assets (Note 11). |
Summary of Significant Accoun51
Summary of Significant Accounting Policies - Rollforward of Allowance for Doubtful Accounts (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Allowance for Doubtful Accounts | |||
Beginning balance | $ 3,703 | $ 2,081 | $ 565 |
Charged to operating expenses | 1,217 | 1,963 | 1,757 |
Write offs of accounts receivable, net of recoveries | (289) | (341) | (241) |
Ending balance | $ 4,631 | $ 3,703 | $ 2,081 |
Summary of Significant Accoun52
Summary of Significant Accounting Policies - Estimated Useful Lives of Property, Plant and Equipment (Details) | 12 Months Ended |
Dec. 31, 2017 | |
Minimum | Land improvements | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 4 years |
Minimum | Building and building improvements | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 3 years |
Minimum | Furniture and fixtures | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 1 year |
Minimum | Equipment | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 1 year |
Minimum | Breeding stock | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 1 year |
Minimum | Computer hardware and software | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 1 year |
Minimum | Leasehold improvements | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 1 year |
Maximum | Land improvements | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 20 years |
Maximum | Building and building improvements | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 25 years |
Maximum | Furniture and fixtures | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 10 years |
Maximum | Equipment | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 10 years |
Maximum | Breeding stock | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 4 years |
Maximum | Computer hardware and software | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 7 years |
Maximum | Leasehold improvements | |
Property, Plant and Equipment [Line Items] | |
Property plant and equipment, useful life | 20 years |
Summary of Significant Accoun53
Summary of Significant Accounting Policies - Summary of Assumptions Used in Option Pricing Model (Details) - Intrexon Stock Option Plans | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||
Expected dividend yield | 0.00% | 0.00% | 0.00% |
Expected volatility, minimum | 57.00% | 59.00% | 59.00% |
Expected volatility, maximum | 60.00% | 60.00% | 62.00% |
Expected term (years) | 6 years 3 months | 6 years 3 months | 6 years 3 months |
Risk-free interest rate, minimum | 1.89% | 1.23% | 1.56% |
Risk-free interest rate, maximum | 2.27% | 2.17% | 1.95% |
Mergers and Acquisitions - GenV
Mergers and Acquisitions - GenVec - Fair Value of Consideration Transferred (Details) - GenVec, Inc. $ in Thousands | 1 Months Ended |
Jun. 30, 2017USD ($) | |
Business Acquisition [Line Items] | |
Common shares | $ 15,616 |
Warrants | 1,381 |
Contingent consideration | 585 |
Total consideration transferred | $ 17,582 |
Mergers and Acquisitions - Ge55
Mergers and Acquisitions - GenVec - Fair Value of Assets Acquired and Liabilities Assumed (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Jun. 30, 2017 | Dec. 31, 2016 | Dec. 31, 2015 |
Business Acquisition [Line Items] | ||||
Goodwill | $ 153,289 | $ 157,175 | $ 165,169 | |
GenVec, Inc. | ||||
Business Acquisition [Line Items] | ||||
Cash and cash equivalents | $ 2,054 | |||
Short term investments | 542 | |||
Trade receivables | 75 | |||
Other receivables | 97 | |||
Prepaid expenses and other | 227 | |||
Property and equipment | 250 | |||
Intangible assets | 14,000 | |||
Other noncurrent assets | 58 | |||
Total assets acquired | 17,303 | |||
Accounts payable | 2,158 | |||
Accrued compensation and benefits | 1,226 | |||
Other accrued expenses | 856 | |||
Other long term liabilities | 92 | |||
Deferred tax liabilities | 239 | |||
Total liabilities assumed | 4,571 | |||
Net assets acquired | 12,732 | |||
Goodwill | 4,850 | |||
Total consideration | $ 17,582 |
Mergers and Acquisitions - Ge56
Mergers and Acquisitions - GenVec - Additional Information (Details) - GenVec, Inc. - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended | |
Jun. 30, 2017 | Dec. 31, 2017 | Dec. 31, 2016 | |
Business Acquisition [Line Items] | |||
Percentage of outstanding common stock acquired | 100.00% | ||
Business combination, consideration paid, shares issued | 684,240 | ||
Collaboration agreement, percent of collaboration payments | 50.00% | ||
Business combination, period subsequent to acquisition during which a portion of collaboration payments received will be paid to former stockholders of acquired entity | 3 years | ||
Expected useful life of intangible asset | 11 years | ||
Business Combination, Consideration Transferred | $ 17,582 | ||
Selling, general and administrative | |||
Business Acquisition [Line Items] | |||
Business combination, acquisition related cost | $ 507 | $ 12 |
Mergers and Acquisitions - Oxit
Mergers and Acquisitions - Oxitec - Fair Value of Consideration Transferred (Details) - Oxitec Limited $ in Thousands | 1 Months Ended |
Sep. 30, 2015USD ($) | |
Business Acquisition [Line Items] | |
Cash | $ 90,199 |
Common shares | 56,195 |
Total consideration transferred | $ 146,394 |
Mergers and Acquisitions - Ox58
Mergers and Acquisitions - Oxitec - Fair Value of Assets Acquired and Liabilities Assumed (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Sep. 30, 2015 |
Business Acquisition [Line Items] | ||||
Goodwill | $ 153,289 | $ 157,175 | $ 165,169 | |
Oxitec Limited | ||||
Business Acquisition [Line Items] | ||||
Cash | $ 3,780 | |||
Trade receivables | 125 | |||
Other receivables | 7,395 | |||
Prepaid expenses and other | 121 | |||
Property, plant, and equipment | 1,198 | |||
Intangible assets | 96,854 | |||
Total assets acquired | 109,473 | |||
Accounts payable | 1,187 | |||
Accrued compensation and benefits | 246 | |||
Other accrued liabilities | 210 | |||
Deferred revenue | 120 | |||
Deferred tax liabilities | 12,584 | |||
Total liabilities assumed | 14,347 | |||
Net assets acquired | 95,126 | |||
Goodwill | 51,268 | |||
Total consideration | $ 146,394 |
Mergers and Acquisitions - Ox59
Mergers and Acquisitions - Oxitec - Additional Information (Details) - Oxitec Limited - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended | |
Nov. 30, 2016 | Sep. 30, 2015 | Dec. 31, 2015 | |
Business Acquisition [Line Items] | |||
Percentage of outstanding common stock acquired | 100.00% | ||
Business combination, consideration paid, shares issued | 1,359,343 | ||
Cash | $ 90,199 | ||
Business combination, consideration transferred, cash and working capital adjustments | $ 9,449 | ||
Business combination, equity interest issued or issuable, number of shares withheld as escrow | 480,422 | ||
Business combination, cash consideration withheld as escrow | $ 1,991 | ||
Expected useful life of intangible asset | 18 years | ||
Selling, general and administrative | |||
Business Acquisition [Line Items] | |||
Business combination, acquisition related cost | $ 1,675 |
Mergers and Acquisitions - Okan
Mergers and Acquisitions - Okanagan - Fair Value of Consideration Transferred (Details) - Okanagan Specialty Fruits Inc. $ in Thousands | 1 Months Ended |
Apr. 30, 2015USD ($) | |
Business Acquisition [Line Items] | |
Cash | $ 10,000 |
Common shares | 30,933 |
Total consideration transferred | $ 40,933 |
Mergers and Acquisitions - Ok61
Mergers and Acquisitions - Okanagan - Fair Value of Assets Acquired and Liabilities Assumed (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Apr. 30, 2015 |
Business Acquisition [Line Items] | ||||
Goodwill | $ 153,289 | $ 157,175 | $ 165,169 | |
Okanagan Specialty Fruits Inc. | ||||
Business Acquisition [Line Items] | ||||
Cash | $ 58 | |||
Trade receivables | 16 | |||
Other receivables | 49 | |||
Property, plant, and equipment | 32 | |||
Intangible assets | 36,500 | |||
Total assets acquired | 36,655 | |||
Accounts payable | 181 | |||
Deferred revenue | 181 | |||
Deferred tax liabilities | 8,847 | |||
Total liabilities assumed | 9,209 | |||
Net assets acquired | 27,446 | |||
Goodwill | 13,487 | |||
Total consideration | $ 40,933 |
Mergers and Acquisitions - Ok62
Mergers and Acquisitions - Okanagan - Additional Information (Details) - Okanagan Specialty Fruits Inc. - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended |
Apr. 30, 2015 | Dec. 31, 2015 | |
Business Acquisition [Line Items] | ||
Percentage of outstanding common stock acquired | 100.00% | |
Business combination, consideration paid, shares issued | 707,853 | |
Cash | $ 10,000 | |
Expected useful life of intangible asset | 14 years | |
Selling, general and administrative | ||
Business Acquisition [Line Items] | ||
Business combination, acquisition related cost | $ 267 |
Mergers and Acquisitions - Acto
Mergers and Acquisitions - ActoGeniX - Fair Value of Consideration Transferred (Details) - ActoGeniX NV $ in Thousands | 1 Months Ended |
Feb. 28, 2015USD ($) | |
Business Acquisition [Line Items] | |
Cash | $ 32,739 |
Common shares | 39,735 |
Total consideration transferred | $ 72,474 |
Mergers and Acquisitions - Ac64
Mergers and Acquisitions - ActoGeniX - Fair Value of Assets Acquired and Liabilities Assumed (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Feb. 28, 2015 |
Business Acquisition [Line Items] | ||||
Goodwill | $ 153,289 | $ 157,175 | $ 165,169 | |
ActoGeniX NV | ||||
Business Acquisition [Line Items] | ||||
Cash | $ 3,180 | |||
Other receivables | 305 | |||
Prepaid expenses and other | 31 | |||
Property, plant, and equipment | 209 | |||
Intangible assets | 68,100 | |||
Other noncurrent assets | 23 | |||
Total assets acquired | 71,848 | |||
Accounts payable | 230 | |||
Accrued compensation and benefits | 196 | |||
Other accrued liabilities | 253 | |||
Deferred revenue | 732 | |||
Deferred tax liabilities | 612 | |||
Total liabilities assumed | 2,023 | |||
Net assets acquired | 69,825 | |||
Goodwill | 2,649 | |||
Total consideration | $ 72,474 |
Mergers and Acquisitions - Ac65
Mergers and Acquisitions - ActoGeniX - Additional Information (Details) - ActoGeniX NV - USD ($) $ in Thousands | 1 Months Ended | 12 Months Ended | |
Aug. 31, 2015 | Feb. 28, 2015 | Dec. 31, 2015 | |
Business Acquisition [Line Items] | |||
Percentage of outstanding common stock acquired | 100.00% | ||
Business combination, consideration paid, shares issued | 965,377 | ||
Cash | $ 32,739 | ||
Expected useful life of intangible asset | 18 years | ||
Selling, general and administrative | |||
Business Acquisition [Line Items] | |||
Business combination, acquisition related cost | $ 381 |
Mergers and Acquisitions - Ge66
Mergers and Acquisitions - GenVec - Pro Forma Financial Information (Details) - GenVec, Inc. - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2017 | Dec. 31, 2016 | |
Business Acquisition, Pro Forma Information, Nonrecurring Adjustment [Line Items] | ||
Revenues | $ 231,213 | $ 191,437 |
Loss before income taxes | (136,966) | (201,210) |
Net loss | (134,275) | (197,144) |
Net loss attributable to the noncontrolling interests | 9,802 | 3,662 |
Net loss attributable to Intrexon | $ (124,473) | $ (193,482) |
Mergers and Acquisitions - 2015
Mergers and Acquisitions - 2015 Acquisitions - Pro Forma Financial Information (Details) - 2015 Business Acquisitions $ in Thousands | 12 Months Ended |
Dec. 31, 2015USD ($) | |
Business Acquisition [Line Items] | |
Revenues | $ 174,558 |
Loss before income taxes | (99,751) |
Net loss | (99,594) |
Net loss attributable to the noncontrolling interests | 3,501 |
Net loss attributable to Intrexon | $ (96,093) |
Investments in Joint Ventures -
Investments in Joint Ventures - S & I Ophthalmic - Additional Information (Details) | 1 Months Ended | 12 Months Ended | ||
Oct. 31, 2013USD ($) | Dec. 31, 2015USD ($) | Dec. 31, 2017USD ($)board_seat | Dec. 31, 2016USD ($) | |
Schedule Of Investments In Joint Venture [Line Items] | ||||
Due from related parties, current | $ 17,913,000 | $ 16,793,000 | ||
Investment | $ 18,870,000 | 23,655,000 | ||
S & I Ophthalmic, LLC | ||||
Schedule Of Investments In Joint Venture [Line Items] | ||||
Capital contribution | $ 5,000,000 | $ 5,000,000 | ||
Membership interest | 50.00% | |||
Total number of seats on the joint venture's governing board | board_seat | 4 | |||
Total number of seats on the joint venture's governing board, externally selected | board_seat | 2 | |||
Total number of seats on the joint venture's governing board, internally selected | board_seat | 2 | |||
S & I Opthalmic, LLC | ||||
Schedule Of Investments In Joint Venture [Line Items] | ||||
Due from related parties, current | $ 2,598,000 | |||
Investor | S & I Ophthalmic, LLC | ||||
Schedule Of Investments In Joint Venture [Line Items] | ||||
Capital contribution | $ 5,000,000 | $ 5,000,000 | ||
Membership interest | 50.00% | |||
Investments in affiliates | S & I Ophthalmic, LLC | ||||
Schedule Of Investments In Joint Venture [Line Items] | ||||
Investment | $ 3,236,000 |
Investments in Joint Ventures69
Investments in Joint Ventures - OvaXon - Additional Information (Details) | 1 Months Ended | 47 Months Ended | |
Jan. 31, 2014USD ($) | Dec. 31, 2017USD ($)board_seat | Dec. 31, 2016USD ($) | |
Schedule Of Investments In Joint Venture [Line Items] | |||
Investment | $ 18,870,000 | $ 23,655,000 | |
OvaXon, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Capital contribution | $ 1,500,000 | $ 4,350,000 | |
Membership interest | 50.00% | ||
Total number of seats on the joint venture's governing board | board_seat | 4 | ||
Total number of seats on the joint venture's governing board, internally selected | board_seat | 2 | ||
Total number of seats on the joint venture's governing board, externally selected | board_seat | 2 | ||
OvaXon, LLC | Investor | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Capital contribution | $ 1,500,000 | $ 4,350,000 | |
Membership interest | 50.00% | ||
Investments in affiliates | OvaXon, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Investment | $ 146,000 | $ 65,000 |
Investments in Joint Ventures70
Investments in Joint Ventures - Intrexon Energy Partners - Additional Information (Details) | 1 Months Ended | ||
Mar. 31, 2014USD ($) | Dec. 31, 2017USD ($)board_seat | Dec. 31, 2016USD ($) | |
Schedule Of Investments In Joint Venture [Line Items] | |||
Investment | $ 18,870,000 | $ 23,655,000 | |
Intrexon Energy Partners, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Membership interest | 50.00% | ||
Maximum additional capital contributions committed | $ 25,000,000 | ||
Additional capital contributions committed, remaining commitment | $ 6,011,000 | ||
Total number of seats on the joint venture's governing board | board_seat | 5 | ||
Total number of seats on the joint venture's governing board, internally selected | board_seat | 2 | ||
Total number of seats on the joint venture's governing board, externally selected | board_seat | 3 | ||
Investor | Intrexon Energy Partners, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Membership interest | 50.00% | ||
Capital contribution | $ 25,000,000 | ||
Maximum additional capital contributions committed | 25,000,000 | ||
Upfront and Milestone Payments | Upfront | Intrexon Energy Partners, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Collaborative agreement, consideration received, value | $ 25,000,000 | ||
Other accrued liabilities | Intrexon Energy Partners, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Investment | $ (444,000) | $ (477,000) |
Investments in Joint Ventures71
Investments in Joint Ventures - Intrexon Energy Partners II - Additional Information (Details) | 1 Months Ended | ||
Dec. 31, 2015USD ($) | Dec. 31, 2017USD ($)board_seat | Dec. 31, 2016USD ($) | |
Schedule Of Investments In Joint Venture [Line Items] | |||
Investment | $ 18,870,000 | $ 23,655,000 | |
Intrexon Energy Partners II, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Membership interest | 50.00% | ||
Maximum additional capital contributions committed | $ 10,000,000 | ||
Total number of seats on the joint venture's governing board | board_seat | 5 | ||
Total number of seats on the joint venture's governing board, internally selected | board_seat | 1 | ||
Total number of seats on the joint venture's governing board, externally selected | board_seat | 4 | ||
Intrexon Energy Partners II, LLC | Upfront and Milestone Payments | Upfront | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Collaborative agreement, consideration received, value | $ 18,000,000 | ||
Investor | Intrexon Energy Partners II, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Membership interest | 50.00% | ||
Capital contribution | $ 18,000,000 | ||
Maximum additional capital contributions committed | 10,000,000 | ||
All Investors | Intrexon Energy Partners II, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Capital contribution | $ 4,000,000 | ||
Investments in affiliates | Intrexon Energy Partners II, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Investment | $ 572,000 | $ 1,414,000 |
Investments in Joint Ventures72
Investments in Joint Ventures - EnviroFlight - Additional Information (Details) - USD ($) | 1 Months Ended | 12 Months Ended | 47 Months Ended | |||||
Oct. 31, 2016 | Feb. 29, 2016 | Jan. 31, 2014 | Oct. 31, 2013 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2017 | |
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Cash paid in asset acquisition | $ 14,219,000 | $ 7,244,000 | $ 0 | |||||
Shares issued in asset acquisition | 0 | 4,401,000 | 0 | |||||
Contingent consideration assumed in asset acquisition | 0 | 3,660,000 | 0 | |||||
Shares issued as payment for contingent consideration | 0 | 1,583,000 | 0 | |||||
Investment | 18,870,000 | 23,655,000 | $ 18,870,000 | |||||
S & I Ophthalmic, LLC | ||||||||
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Capital contribution | $ 5,000,000 | 5,000,000 | ||||||
Membership interest | 50.00% | |||||||
OvaXon, LLC | ||||||||
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Capital contribution | $ 1,500,000 | 4,350,000 | ||||||
Membership interest | 50.00% | |||||||
EnviroFlight, LLC | ||||||||
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Cash paid in asset acquisition | $ 4,244,000 | |||||||
Shares issued in asset acquisition, shares | 136,340 | |||||||
Shares issued in asset acquisition | $ 4,401,000 | |||||||
Contingent consideration assumed in asset acquisition | 3,660,000 | |||||||
Capital contribution | $ 3,000,000 | |||||||
Membership interest | 50.00% | |||||||
Maximum additional capital contributions committed | $ 5,000,000 | |||||||
Additional capital contributions committed, remaining commitment | 250,000 | 250,000 | ||||||
Estimated fair value of investment | 5,425,000 | |||||||
Shares issued as payment for contingent consideration, shares | 59,337 | |||||||
Shares issued as payment for contingent consideration | $ 1,583,000 | |||||||
Contingent consideration for commercial milestones payable in common stock, maximum | $ 4,000,000 | |||||||
Investor | S & I Ophthalmic, LLC | ||||||||
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Capital contribution | $ 5,000,000 | $ 5,000,000 | ||||||
Membership interest | 50.00% | |||||||
Investor | OvaXon, LLC | ||||||||
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Capital contribution | $ 1,500,000 | 4,350,000 | ||||||
Membership interest | 50.00% | |||||||
Investor | EnviroFlight, LLC | ||||||||
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Membership interest | 50.00% | |||||||
Maximum additional capital contributions committed | $ 5,000,000 | |||||||
Patents, developed technologies and know-how | EnviroFlight, LLC | ||||||||
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Estimated fair value of developed technology acquired | $ 9,880,000 | |||||||
Expected useful life of intangible asset | 21 years | |||||||
Investments in affiliates | S & I Ophthalmic, LLC | ||||||||
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Investment | 3,236,000 | |||||||
Investments in affiliates | OvaXon, LLC | ||||||||
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Investment | 146,000 | 65,000 | 146,000 | |||||
Investments in affiliates | EnviroFlight, LLC | ||||||||
Schedule Of Investments In Joint Venture [Line Items] | ||||||||
Investment | $ 7,092,000 | $ 4,189,000 | $ 7,092,000 |
Investments in Joint Ventures73
Investments in Joint Ventures - Intrexon T1D Partners - Additional Information (Details) | 1 Months Ended | ||
Mar. 31, 2016USD ($) | Dec. 31, 2017USD ($)board_seat | Dec. 31, 2016USD ($) | |
Schedule Of Investments In Joint Venture [Line Items] | |||
Investment | $ 18,870,000 | $ 23,655,000 | |
Intrexon T1D Partners, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Membership interest | 50.00% | ||
Maximum additional capital contributions committed | $ 5,000,000 | ||
Additional capital contributions committed, remaining commitment | $ 2,900,000 | ||
Total number of seats on the joint venture's governing board | board_seat | 5 | ||
Total number of seats on the joint venture's governing board, internally selected | board_seat | 2 | ||
Total number of seats on the joint venture's governing board, externally selected | board_seat | 3 | ||
Upfront | Intrexon T1D Partners, LLC | Upfront and Milestone Payments | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Collaborative agreement, consideration received, value | $ 10,000,000 | ||
Investor | Intrexon T1D Partners, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Membership interest | 50.00% | ||
Capital contribution | $ 10,000,000 | ||
Maximum additional capital contributions committed | $ 5,000,000 | ||
Investments in affiliates | Intrexon T1D Partners, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Investment | $ 806,000 | ||
Other accrued liabilities | Intrexon T1D Partners, LLC | |||
Schedule Of Investments In Joint Venture [Line Items] | |||
Investment | $ (943,000) |
Collaboration and Licensing R74
Collaboration and Licensing Revenue - Summarized Collaboration and Licensing Revenues (Details) - USD ($) $ in Thousands | 12 Months Ended | |||||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | ||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | $ 145,579 | $ 109,871 | $ 87,821 | |||
ZIOPHARM Oncology, Inc. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 69,812 | 33,836 | 19,306 | |||
Oragenics, Inc. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 2,020 | 2,752 | 6,535 | |||
Fibrocell Science, Inc. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 7,344 | 5,942 | 12,179 | |||
Genopaver, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 6,690 | 6,117 | 3,829 | |||
S & I Ophthalmic, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 755 | 6,141 | 4,115 | |||
OvaXon, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 1,966 | 2,934 | 2,540 | |||
Intrexon Energy Partners, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 10,665 | 17,552 | 13,447 | |||
Persea Bio, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 946 | 1,278 | 1,241 | |||
Ares Trading S.A. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 10,738 | 10,192 | 4,728 | |||
Intrexon Energy Partners II, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 3,672 | 3,169 | 167 | |||
Intrexon T1D Partners, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 5,968 | 1,908 | ||||
Harvest Start-Up Entities | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 15,232 | [1] | 4,974 | [2] | 266 | [3] |
Other | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 9,771 | 13,076 | 19,468 | |||
Upfront and Milestone Payments | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 71,637 | 34,433 | 32,513 | |||
Upfront and Milestone Payments | ZIOPHARM Oncology, Inc. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 48,313 | 11,529 | 2,855 | |||
Upfront and Milestone Payments | Oragenics, Inc. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 1,047 | 1,047 | 5,679 | |||
Upfront and Milestone Payments | Fibrocell Science, Inc. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 2,419 | 2,419 | 6,046 | |||
Upfront and Milestone Payments | Genopaver, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 273 | 273 | 273 | |||
Upfront and Milestone Payments | S & I Ophthalmic, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 0 | 0 | 0 | |||
Upfront and Milestone Payments | OvaXon, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 0 | 0 | 0 | |||
Upfront and Milestone Payments | Intrexon Energy Partners, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 2,500 | 2,500 | 2,500 | |||
Upfront and Milestone Payments | Persea Bio, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 500 | 500 | 500 | |||
Upfront and Milestone Payments | Ares Trading S.A. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 6,389 | 6,389 | 3,933 | |||
Upfront and Milestone Payments | Intrexon Energy Partners II, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 2,000 | 2,000 | 167 | |||
Upfront and Milestone Payments | Intrexon T1D Partners, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 1,109 | 821 | ||||
Upfront and Milestone Payments | Harvest Start-Up Entities | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 2,442 | [1] | 1,383 | [2] | 46 | [3] |
Upfront and Milestone Payments | Other | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 4,645 | 5,572 | 10,514 | |||
Research and Development Services | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 73,942 | 75,438 | 55,308 | |||
Research and Development Services | ZIOPHARM Oncology, Inc. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 21,499 | 22,307 | 16,451 | |||
Research and Development Services | Oragenics, Inc. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 973 | 1,705 | 856 | |||
Research and Development Services | Fibrocell Science, Inc. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 4,925 | 3,523 | 6,133 | |||
Research and Development Services | Genopaver, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 6,417 | 5,844 | 3,556 | |||
Research and Development Services | S & I Ophthalmic, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 755 | 6,141 | 4,115 | |||
Research and Development Services | OvaXon, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 1,966 | 2,934 | 2,540 | |||
Research and Development Services | Intrexon Energy Partners, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 8,165 | 15,052 | 10,947 | |||
Research and Development Services | Persea Bio, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 446 | 778 | 741 | |||
Research and Development Services | Ares Trading S.A. | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 4,349 | 3,803 | 795 | |||
Research and Development Services | Intrexon Energy Partners II, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 1,672 | 1,169 | 0 | |||
Research and Development Services | Intrexon T1D Partners, LLC | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 4,859 | 1,087 | ||||
Research and Development Services | Harvest Start-Up Entities | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | 12,790 | [1] | 3,591 | [2] | 220 | [3] |
Research and Development Services | Other | ||||||
Collaborative Arrangements and Non-collaborative Arrangement Transactions [Line Items] | ||||||
Collaboration and licensing revenues | $ 5,126 | $ 7,504 | $ 8,954 | |||
[1] | For the year ended December 31, 2017, revenue recognized from collaborations with Harvest start-up entities include Thrive Agrobiotics, Inc.; Exotech Bio, Inc.; Relieve Genetics, Inc.; AD Skincare, Inc.; Genten Therapeutics, Inc.; and CRS Bio, Inc. | |||||
[2] | For the year ended December 31, 2016, revenue recognized from collaborations with Harvest start-up entities include Thrive Agrobiotics, Inc.; Exotech Bio, Inc.; Relieve Genetics, Inc.; AD Skincare, Inc.; Genten Therapeutics, Inc.; and CRS Bio, Inc. | |||||
[3] | For the year ended December 31, 2015, revenue recognized from collaborations with Harvest start-up entities include Thrive Agrobiotics, Inc. |
Collaboration and Licensing R75
Collaboration and Licensing Revenue - Summary of Deferred Revenue (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 |
Deferred Revenue Arrangement [Line Items] | ||
Current portion of deferred revenue | $ 42,870 | $ 53,364 |
Long-term portion of deferred revenue | 193,527 | 256,778 |
Deferred revenue | 236,397 | 310,142 |
Upfront and milestone payments | ||
Deferred Revenue Arrangement [Line Items] | ||
Deferred revenue | 230,531 | 297,867 |
Prepaid research and development services | ||
Deferred Revenue Arrangement [Line Items] | ||
Deferred revenue | 1,052 | 6,015 |
Prepaid product and service revenues | ||
Deferred Revenue Arrangement [Line Items] | ||
Deferred revenue | 4,681 | 5,554 |
Other | ||
Deferred Revenue Arrangement [Line Items] | ||
Deferred revenue | $ 133 | $ 706 |
Collaboration and Licensing R76
Collaboration and Licensing Revenue - Summary of Deferred Revenue by Collaborator (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 | |
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | $ 236,397 | $ 310,142 | |
Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | 230,531 | 297,867 | |
ZIOPHARM Oncology, Inc. | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | 90,496 | 138,809 | |
Oragenics, Inc. | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | 6,719 | 7,766 | |
Fibrocell Science, Inc. | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | 16,607 | 19,026 | |
Genopaver, LLC | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | 1,704 | 1,977 | |
Intrexon Energy Partners, LLC | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | 15,625 | 18,125 | |
Persea Bio, LLC | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | 3,500 | 4,000 | |
Ares Trading S.A. | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | 40,789 | 47,178 | |
Intrexon Energy Partners II, LLC | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | 13,833 | 15,833 | |
Intrexon T1D Partners, LLC | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | 8,435 | 8,653 | |
Harvest Start-Up Entities | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | [1] | 18,400 | 20,208 |
Other | Upfront and Milestone Payments | |||
Summary of Deferred Revenue by Collaborator [Line Items] | |||
Deferred revenue | $ 14,423 | $ 16,292 | |
[1] | As of December 31, 2017 and December 31, 2016, the balance of deferred revenue for collaborations with Harvest start-up entities includes Thrive Agrobiotics, Inc.; Exotech Bio, Inc.; Relieve Genetics, Inc.; AD Skincare, Inc.; Genten Therapeutics, Inc.; and CRS Bio, Inc. |
Collaboration and Licensing R77
Collaboration and Licensing Revenue - Additional Information (Details) | Jan. 19, 2018 | Mar. 10, 2017 | Dec. 31, 2017USD ($) | Nov. 30, 2017USD ($) | Sep. 30, 2016USD ($) | Jun. 30, 2016USD ($)shares | Mar. 31, 2016USD ($) | Dec. 31, 2015USD ($)shares | Sep. 30, 2015USD ($) | Jun. 30, 2015USD ($) | May 31, 2015USD ($)target | Dec. 31, 2014USD ($) | Mar. 31, 2014USD ($) | Jan. 31, 2014USD ($)shares | Dec. 31, 2013shares | Sep. 30, 2013USD ($)shares | Jun. 30, 2013USD ($)shares | Mar. 31, 2013USD ($) | Feb. 28, 2013 | Oct. 31, 2012USD ($)shares | Jun. 30, 2012USD ($)shares | Jan. 31, 2011USD ($)shares | May 31, 2016 | Dec. 31, 2017USD ($) | Dec. 31, 2016USD ($) | Dec. 31, 2015USD ($) |
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | $ 145,579,000 | $ 109,871,000 | $ 87,821,000 | |||||||||||||||||||||||
Deferred revenue | $ 236,397,000 | 236,397,000 | 310,142,000 | |||||||||||||||||||||||
Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 71,637,000 | 34,433,000 | 32,513,000 | |||||||||||||||||||||||
Deferred revenue | 230,531,000 | 230,531,000 | 297,867,000 | |||||||||||||||||||||||
Prepaid research and development services | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Deferred revenue | 1,052,000 | 1,052,000 | 6,015,000 | |||||||||||||||||||||||
ZIOPHARM ECC 1 | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Percentage of shares outstanding at the date of achievement of future milestone | 7.495% | |||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
ZIOPHARM ECC 1 | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received (in shares) | shares | 3,636,926 | |||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 17,457,000 | |||||||||||||||||||||||||
ZIOPHARM ECC 1 | Milestone One | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received (in shares) | shares | 3,636,926 | |||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 18,330,000 | |||||||||||||||||||||||||
ZIOPHARM ECC 1 Separate Unit Of Accounting | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 1,115,000 | |||||||||||||||||||||||||
ZIOPHARM ECC 1 Unit of Accounting 1 | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Deferred revenue | $ 16,342,000 | |||||||||||||||||||||||||
ZIOPHARM Oncology, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 69,812,000 | 33,836,000 | 19,306,000 | |||||||||||||||||||||||
Royalty rate as a percentage of net profit | 20.00% | 50.00% | ||||||||||||||||||||||||
ZIOPHARM Oncology, Inc. | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 48,313,000 | 11,529,000 | 2,855,000 | |||||||||||||||||||||||
Deferred revenue | 90,496,000 | 90,496,000 | 138,809,000 | |||||||||||||||||||||||
ZIOPHARM Oncology, Inc. | Other Contractual Payments | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 120,000,000 | |||||||||||||||||||||||||
Collaborative arrangement consideration received, number of preferred shares (in shares) | shares | 100,000 | |||||||||||||||||||||||||
Ares Trading S.A. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 10,738,000 | 10,192,000 | 4,728,000 | |||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Collaborative agreement, additional target fee | $ 5,000,000 | |||||||||||||||||||||||||
Ares Trading S.A. | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 6,389,000 | 6,389,000 | 3,933,000 | |||||||||||||||||||||||
Deferred revenue | 40,789,000 | 40,789,000 | 47,178,000 | |||||||||||||||||||||||
Ares Trading S.A. | Prepaid research and development services | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Deferred revenue | $ 10,000,000 | |||||||||||||||||||||||||
Collaborative agreement, consideration receivable, minimum targets required | target | 2 | |||||||||||||||||||||||||
Collaborative agreement, consideration receivable, collection period | 2 years | |||||||||||||||||||||||||
Ares Trading S.A. | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 115,000,000 | |||||||||||||||||||||||||
ZIOPHARM ECC 2 | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 10,000,000 | |||||||||||||||||||||||||
Collaboration and licensing revenues | 28,943,000 | |||||||||||||||||||||||||
Oragenics ECC 1 | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Royalty rate as a percentage of net profit | 25.00% | |||||||||||||||||||||||||
Oragenics ECC 1 | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received (in shares) | shares | 439,243 | |||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 6,588,000 | |||||||||||||||||||||||||
Oragenics ECC 2 | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received (in shares) | shares | 134,800 | |||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 3,503,000 | |||||||||||||||||||||||||
Collaborative agreement, consideration received, value of convertible promissory note | $ 1,956,000 | |||||||||||||||||||||||||
Conversion of promissory note into common stock (in shares) | shares | 69,824 | |||||||||||||||||||||||||
Oragenics ECC 3 | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Oragenics ECC 3 | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value of convertible promissory note | $ 5,000,000 | |||||||||||||||||||||||||
Conversion of promissory note into common stock (in shares) | shares | 338,100 | |||||||||||||||||||||||||
Fibrocell ECC 1 | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Royalty rate as a percentage of net sales, tier 1 | 7.00% | |||||||||||||||||||||||||
Level of net sales at which royalty rate changes to tier 2 | $ 25,000,000 | |||||||||||||||||||||||||
Royalty rate as a percentage of net sales, tier 2 | 14.00% | |||||||||||||||||||||||||
Royalty rate of savings from improvement | 33.00% | |||||||||||||||||||||||||
Fibrocell ECC 1 | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received (in shares) | shares | 439,173 | |||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 7,576,000 | |||||||||||||||||||||||||
Fibrocell ECC 1 | Supplemental Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received (in shares) | shares | 341,530 | 414,594 | ||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 5,225,000 | $ 7,612,000 | ||||||||||||||||||||||||
Fibrocell ECC 2 | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Maximum milestone payments required upon successful achievement, first product | $ 30,000,000 | |||||||||||||||||||||||||
Maximum milestone payments required upon successful achievement, per each additional product | 30,000,000 | |||||||||||||||||||||||||
Maximum milestone payments required for certain sales milestones, per product | 22,500,000 | |||||||||||||||||||||||||
Fibrocell ECC 2 | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 10,000,000 | |||||||||||||||||||||||||
Genopaver, LLC | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 6,690,000 | 6,117,000 | 3,829,000 | |||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Genopaver, LLC | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 273,000 | 273,000 | 273,000 | |||||||||||||||||||||||
Deferred revenue | 1,704,000 | 1,704,000 | 1,977,000 | |||||||||||||||||||||||
Genopaver, LLC | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 3,000,000 | |||||||||||||||||||||||||
AquaBounty Technologies, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Royalty rate as a percentage of gross profit | 16.66% | |||||||||||||||||||||||||
S & I Ophthalmic, LLC | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 755,000 | 6,141,000 | 4,115,000 | |||||||||||||||||||||||
S & I Ophthalmic, LLC | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 0 | 0 | 0 | |||||||||||||||||||||||
OvaXon, LLC | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 1,966,000 | 2,934,000 | 2,540,000 | |||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
OvaXon, LLC | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 0 | 0 | 0 | |||||||||||||||||||||||
Intrexon Energy Partners, LLC | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 10,665,000 | 17,552,000 | 13,447,000 | |||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Intrexon Energy Partners, LLC | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 2,500,000 | 2,500,000 | 2,500,000 | |||||||||||||||||||||||
Deferred revenue | 15,625,000 | 15,625,000 | 18,125,000 | |||||||||||||||||||||||
Intrexon Energy Partners, LLC | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 25,000,000 | |||||||||||||||||||||||||
Persea Bio, LLC | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 946,000 | 1,278,000 | 1,241,000 | |||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Persea Bio, LLC | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 500,000 | 500,000 | 500,000 | |||||||||||||||||||||||
Deferred revenue | 3,500,000 | 3,500,000 | 4,000,000 | |||||||||||||||||||||||
Persea Bio, LLC | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 5,000,000 | |||||||||||||||||||||||||
Thrive Agrobiotics, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Thrive Agrobiotics, Inc. | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 1,667,000 | |||||||||||||||||||||||||
Intrexon Energy Partners II, LLC | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 3,672,000 | 3,169,000 | 167,000 | |||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Intrexon Energy Partners II, LLC | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 2,000,000 | 2,000,000 | $ 167,000 | |||||||||||||||||||||||
Deferred revenue | 13,833,000 | 13,833,000 | 15,833,000 | |||||||||||||||||||||||
Intrexon Energy Partners II, LLC | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 18,000,000 | |||||||||||||||||||||||||
Exotech Bio, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Exotech Bio, Inc. | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 5,000,000 | |||||||||||||||||||||||||
Relieve Genetics, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Relieve Genetics, Inc. | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 4,333,000 | |||||||||||||||||||||||||
Intrexon T1D Partners, LLC | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 5,968,000 | 1,908,000 | ||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Intrexon T1D Partners, LLC | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration and licensing revenues | 1,109,000 | 821,000 | ||||||||||||||||||||||||
Deferred revenue | $ 8,435,000 | $ 8,435,000 | $ 8,653,000 | |||||||||||||||||||||||
Intrexon T1D Partners, LLC | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 10,000,000 | |||||||||||||||||||||||||
AD Skincare, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
AD Skincare, Inc. | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 4,333,000 | |||||||||||||||||||||||||
Genten Therapeutics, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
Genten Therapeutics, Inc. | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 3,000,000 | |||||||||||||||||||||||||
Collaborative agreement, consideration received, cash | $ 1,500,000 | |||||||||||||||||||||||||
CRS Bio, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Required notice period for voluntary termination of collaborative agreement | 90 days | |||||||||||||||||||||||||
CRS Bio, Inc. | Upfront | Upfront and Milestone Payments | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaborative agreement, consideration received, value | $ 2,100,000 | |||||||||||||||||||||||||
ZIOPHARM Oncology, Inc. | Ares Trading S.A. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Collaboration agreement, percent of collaboration payments | 50.00% | |||||||||||||||||||||||||
Payments to related parties | 57,500,000 | |||||||||||||||||||||||||
Maximum | Ares Trading S.A. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Milestone payments required upon successful achievement, per product | 413,000,000 | |||||||||||||||||||||||||
Milestone payments required upon successful achievement, one-time | $ 50,000,000 | |||||||||||||||||||||||||
Maximum | Oragenics ECC 1 | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Milestone payments required upon successful achievement, one-time | $ 35,000,000 | |||||||||||||||||||||||||
Maximum | Oragenics ECC 3 | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Milestone payments required upon successful achievement, per product | $ 5,500,000 | 22,000,000 | ||||||||||||||||||||||||
Milestone payments required upon successful achievement, one-time | $ 10,000,000 | |||||||||||||||||||||||||
Maximum | Thrive Agrobiotics, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Milestone payments required upon successful achievement, per product | $ 5,500,000 | |||||||||||||||||||||||||
Maximum | Exotech Bio, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Milestone payments required upon successful achievement, per product | 52,500,000 | |||||||||||||||||||||||||
Maximum | Relieve Genetics, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Milestone payments required upon successful achievement, per product | $ 52,500,000 | |||||||||||||||||||||||||
Maximum | AD Skincare, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Milestone payments required upon successful achievement, per product | 2,000,000 | |||||||||||||||||||||||||
Milestone payments required upon successful achievement, one-time | $ 17,000,000 | |||||||||||||||||||||||||
Maximum | Genten Therapeutics, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Milestone payments required upon successful achievement, per product | 82,000,000 | |||||||||||||||||||||||||
Maximum | CRS Bio, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Milestone payments required upon successful achievement, per product | $ 75,000,000 | |||||||||||||||||||||||||
Fibrocell Science, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Stockholders' equity, reverse stock split | 1-for-3 | |||||||||||||||||||||||||
Stockholders' equity reverse stock split conversion ratio | 0.3333 | |||||||||||||||||||||||||
Subsequent Event | Oragenics, Inc. | ||||||||||||||||||||||||||
Collaboration Agreements [Line Items] | ||||||||||||||||||||||||||
Stockholders' equity, reverse stock split | 1-for-10 | |||||||||||||||||||||||||
Stockholders' equity reverse stock split conversion ratio | 0.1 |
Short-term and Long-term Inve78
Short-term and Long-term Investments - Summary of Amortized Cost, Gross Unrealized Gains and Losses and Fair Value of Short-term and Long-term Investments (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 |
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | $ 6,275 | $ 180,684 |
Gross Unrealized Gains | 0 | 5 |
Gross Unrealized Losses | (2) | (94) |
Aggregate Fair Value | 6,273 | 180,595 |
U.S. government debt securities | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 6,000 | 180,412 |
Gross Unrealized Gains | 0 | 5 |
Gross Unrealized Losses | (2) | (94) |
Aggregate Fair Value | 5,998 | 180,323 |
Certificates of deposit | ||
Schedule of Available-for-sale Securities [Line Items] | ||
Amortized Cost | 275 | 272 |
Gross Unrealized Gains | 0 | 0 |
Gross Unrealized Losses | 0 | 0 |
Aggregate Fair Value | $ 275 | $ 272 |
Investments in Preferred Stoc79
Investments in Preferred Stock - Additional Information (Details) $ / shares in Units, $ in Thousands | Mar. 10, 2017 | Nov. 30, 2017USD ($) | Mar. 31, 2017USD ($)shares | Jun. 30, 2016$ / sharesshares | Dec. 31, 2017USD ($)$ / sharesshares | Dec. 31, 2016USD ($)shares | Dec. 31, 2015USD ($) |
Schedule of Investments [Line Items] | |||||||
Noncash dividend income on preferred shares | $ 16,756 | $ 7,421 | $ 0 | ||||
Purchase of preferred stock | 1,161 | 2,308 | 17,080 | ||||
Fair value of financial assets measured at fair value on a recurring basis | 183,173 | 335,307 | |||||
Receivables converted to preferred stock | $ 3,385 | $ 0 | $ 0 | ||||
Fibrocell Science, Inc. | |||||||
Schedule of Investments [Line Items] | |||||||
Convertible preferred shares, shares issued | shares | 1,161 | ||||||
Number of common shares into which warrants are convertible (in shares) | shares | 498,843 | ||||||
Stockholders' equity reverse stock split conversion ratio | 0.3333 | ||||||
Preferred stock, dividend rate, percentage | 4.00% | ||||||
Stockholders' equity, reverse stock split | 1-for-3 | ||||||
ZIOPHARM Oncology, Inc. | |||||||
Schedule of Investments [Line Items] | |||||||
Preferred shares, stated value (in usd per share) | $ / shares | $ 1,200 | ||||||
Threshold consecutive trading days, conversion in shares | 20 days | ||||||
Preferred shares, dividend rate (in usd per share) | $ / shares | $ 12 | ||||||
Preferred shares, dividend rate, for unconverted shares after conversion event (in usd per share) | $ / shares | 24 | ||||||
Minimum | ZIOPHARM Oncology, Inc. | |||||||
Schedule of Investments [Line Items] | |||||||
Preferred shares, conversion calculation, divisor (in usd per share) | $ / shares | $ 1 | ||||||
ZIOPHARM Oncology, Inc. | |||||||
Schedule of Investments [Line Items] | |||||||
Dividend income, number of preferred shares received (in shares) | shares | 13,460 | 6,184 | |||||
Other Contractual Payments | Upfront and Milestone Payments | ZIOPHARM Oncology, Inc. | |||||||
Schedule of Investments [Line Items] | |||||||
Collaborative arrangement consideration received, number of preferred shares (in shares) | shares | 100,000 | ||||||
ZIOPHARM Oncology, Inc. | |||||||
Schedule of Investments [Line Items] | |||||||
Noncash dividend income on preferred shares | $ 16,717 | $ 7,421 | |||||
Fibrocell Science, Inc. | |||||||
Schedule of Investments [Line Items] | |||||||
Purchase of preferred stock | $ 1,161 | ||||||
Preferred stock | |||||||
Schedule of Investments [Line Items] | |||||||
Fair value of financial assets measured at fair value on a recurring basis | 161,225 | 129,545 | |||||
Preferred stock | ZIOPHARM Oncology, Inc. | |||||||
Schedule of Investments [Line Items] | |||||||
Fair value of financial assets measured at fair value on a recurring basis | 160,832 | $ 129,545 | |||||
Preferred stock | Oragenics, Inc. | |||||||
Schedule of Investments [Line Items] | |||||||
Fair value of financial assets measured at fair value on a recurring basis | $ 0 | ||||||
Receivables converted to preferred stock | $ 3,385 | ||||||
Preferred stock, initial dividend rate | 12.00% | ||||||
Preferred stock, subsequent dividend rate | 20.00% | ||||||
Preferred stock | Fibrocell Science, Inc. | |||||||
Schedule of Investments [Line Items] | |||||||
Fair value of financial assets measured at fair value on a recurring basis | $ 393 |
Investments in Preferred Stoc80
Investments in Preferred Stock - Schedule of Changes in Level 3 Investments (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | |||
Receipt of preferred stock as consideration for amendments to collaboration agreements | $ 0 | $ 120,000 | $ 0 |
Purchase of preferred stock | 1,161 | 2,308 | 17,080 |
Conversion of receivables to preferred stock | 3,385 | 0 | 0 |
Dividend income from investments in preferred stock | 16,756 | 7,421 | 0 |
Significant Unobservable Inputs (Level 3) | |||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | |||
Beginning balance | 129,545 | 0 | |
Receipt of preferred stock as consideration for amendments to collaboration agreements | 0 | 120,000 | |
Purchase of preferred stock | 766 | 0 | |
Conversion of receivables to preferred stock | 3,385 | 0 | |
Dividend income from investments in preferred stock | 16,756 | 7,421 | |
Net unrealized appreciation in the fair value of the investments in preferred stock | 10,773 | 2,124 | |
Ending balance | $ 161,225 | $ 129,545 | $ 0 |
Fair Value Measurements - Summa
Fair Value Measurements - Summary of Placement in the Fair Value Hierarchy of Financial Assets that are Measured at Fair Value on a Recurring Basis (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 |
Assets | ||
Fair value of assets | $ 183,173 | $ 335,307 |
US government debt securities | ||
Assets | ||
Fair value of assets | 5,998 | 180,323 |
Equity securities | ||
Assets | ||
Fair value of assets | 15,100 | 23,522 |
Preferred stock | ||
Assets | ||
Fair value of assets | 161,225 | 129,545 |
Other | ||
Assets | ||
Fair value of assets | 850 | 1,917 |
Quoted Prices in Active Markets (Level 1) | ||
Assets | ||
Fair value of assets | 10,537 | 15,544 |
Quoted Prices in Active Markets (Level 1) | US government debt securities | ||
Assets | ||
Fair value of assets | 0 | 0 |
Quoted Prices in Active Markets (Level 1) | Equity securities | ||
Assets | ||
Fair value of assets | 10,537 | 15,544 |
Quoted Prices in Active Markets (Level 1) | Preferred stock | ||
Assets | ||
Fair value of assets | 0 | 0 |
Quoted Prices in Active Markets (Level 1) | Other | ||
Assets | ||
Fair value of assets | 0 | 0 |
Significant Other Observable Inputs (Level 2) | ||
Assets | ||
Fair value of assets | 11,411 | 190,218 |
Significant Other Observable Inputs (Level 2) | US government debt securities | ||
Assets | ||
Fair value of assets | 5,998 | 180,323 |
Significant Other Observable Inputs (Level 2) | Equity securities | ||
Assets | ||
Fair value of assets | 4,563 | 7,978 |
Significant Other Observable Inputs (Level 2) | Preferred stock | ||
Assets | ||
Fair value of assets | 0 | 0 |
Significant Other Observable Inputs (Level 2) | Other | ||
Assets | ||
Fair value of assets | 850 | 1,917 |
Significant Unobservable Inputs (Level 3) | ||
Assets | ||
Fair value of assets | 161,225 | 129,545 |
Significant Unobservable Inputs (Level 3) | US government debt securities | ||
Assets | ||
Fair value of assets | 0 | 0 |
Significant Unobservable Inputs (Level 3) | Equity securities | ||
Assets | ||
Fair value of assets | 0 | 0 |
Significant Unobservable Inputs (Level 3) | Preferred stock | ||
Assets | ||
Fair value of assets | 161,225 | 129,545 |
Significant Unobservable Inputs (Level 3) | Other | ||
Assets | ||
Fair value of assets | $ 0 | $ 0 |
Fair Value Measurements - Addit
Fair Value Measurements - Additional Information (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 |
Significant Unobservable Inputs (Level 3) | ||
Fair Value, Assets and Liabilities Measured on Recurring and Nonrecurring Basis [Line Items] | ||
Fair value of liabilities | $ 585 | $ 2,081 |
Fair Value Measurements - Sched
Fair Value Measurements - Schedule of Changes in Level 3 Liabilities (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] | |||
Contingent consideration assumed in asset acquisition | $ 0 | $ 3,660 | $ 0 |
Payment of contingent consideration | 0 | (1,583) | 0 |
Significant Unobservable Inputs (Level 3) | |||
Fair Value, Liabilities Measured on Recurring Basis, Unobservable Input Reconciliation, Calculation [Roll Forward] | |||
Beginning balance | 2,081 | 0 | |
Contingent consideration assumed in asset acquisition | 585 | 3,660 | |
Payment of contingent consideration | 0 | (1,583) | |
Change in fair value of contingent consideration | (2,081) | 4 | |
Ending Balance | $ 585 | $ 2,081 | $ 0 |
Inventory - Schedule of Invento
Inventory - Schedule of Inventory (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 |
Inventory [Line Items] | ||
Inventory | $ 20,493 | $ 21,139 |
Supplies, embryos and other production materials | ||
Inventory [Line Items] | ||
Inventory | 2,673 | 1,835 |
Work in process | ||
Inventory [Line Items] | ||
Inventory | 4,767 | 5,466 |
Livestock | ||
Inventory [Line Items] | ||
Inventory | 11,040 | 11,752 |
Feed | ||
Inventory [Line Items] | ||
Inventory | $ 2,013 | $ 2,086 |
Property, Plant and Equipment85
Property, Plant and Equipment, Net - Schedule of Property, Plant and Equipment (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 |
Property, Plant and Equipment [Abstract] | ||
Land and land improvements | $ 11,767 | $ 10,904 |
Buildings and building improvements | 18,183 | 8,123 |
Furniture and fixtures | 2,515 | 2,176 |
Equipment | 65,863 | 44,392 |
Leasehold improvements | 25,277 | 15,105 |
Breeding stock | 3,832 | 3,893 |
Computer hardware and software | 10,128 | 6,844 |
Trees | 6,642 | 2,772 |
Construction and other assets in progress | 14,113 | 4,513 |
Property, plant and equipment, gross | 158,320 | 98,722 |
Less: Accumulated depreciation and amortization | (45,646) | (34,050) |
Property, plant and equipment, net | $ 112,674 | $ 64,672 |
Property, Plant and Equipment86
Property, Plant and Equipment, Net - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Property, Plant and Equipment [Abstract] | |||
Depreciation expense | $ 11,951 | $ 9,387 | $ 7,872 |
Cash paid in asset acquisition | $ 14,219 | $ 7,244 | $ 0 |
Goodwill and Intangible Asset87
Goodwill and Intangible Assets, Net - Additional Information (Details) - USD ($) | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Goodwill [Line Items] | |||
Goodwill impairment charge | $ (13,823,000) | $ 0 | |
Accumulated impairment losses | 0 | ||
Impairment charge | 2,950,000 | ||
Amortization expense | 19,194,000 | $ 15,185,000 | $ 9,871,000 |
AquaBounty Technologies, Inc. | |||
Goodwill [Line Items] | |||
Goodwill impairment charge | $ (13,001,000) |
Goodwill and Intangible Asset88
Goodwill and Intangible Assets, Net - Schedule of Changes in Carrying Amount of Goodwill (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2017 | Dec. 31, 2016 | |
Goodwill | ||
Beginning Balance | $ 157,175 | $ 165,169 |
Acquisitions | 4,850 | 0 |
Impairment | (13,823) | 0 |
Foreign currency translation adjustments | 5,087 | (7,994) |
Ending Balance | $ 153,289 | $ 157,175 |
Goodwill and Intangible Asset89
Goodwill and Intangible Assets, Net - Schedule of Intangible Assets (Details) - USD ($) $ in Thousands | 12 Months Ended | |
Dec. 31, 2017 | Dec. 31, 2016 | |
Finite-Lived Intangible Assets [Line Items] | ||
Gross Carrying Amount | $ 286,781 | $ 262,166 |
Accumulated Amortization | (53,904) | (36,551) |
Net | 232,877 | 225,615 |
Patents, developed technologies and know-how | ||
Finite-Lived Intangible Assets [Line Items] | ||
Gross Carrying Amount | 263,615 | 236,401 |
Accumulated Amortization | (44,954) | (29,748) |
Net | 218,661 | 206,653 |
Customer relationships | ||
Finite-Lived Intangible Assets [Line Items] | ||
Gross Carrying Amount | 10,700 | 10,700 |
Accumulated Amortization | (6,383) | (4,672) |
Net | 4,317 | 6,028 |
Trademarks | ||
Finite-Lived Intangible Assets [Line Items] | ||
Gross Carrying Amount | 6,800 | 6,800 |
Accumulated Amortization | (2,567) | (1,792) |
Net | 4,233 | 5,008 |
Covenant not to compete | ||
Finite-Lived Intangible Assets [Line Items] | ||
Gross Carrying Amount | 370 | |
Accumulated Amortization | (339) | |
Net | 31 | |
In-process research and development | ||
Finite-Lived Intangible Assets [Line Items] | ||
Gross Carrying Amount | 5,666 | 7,895 |
Net | $ 5,666 | $ 7,895 |
Weighted Average | Patents, developed technologies and know-how | ||
Finite-Lived Intangible Assets [Line Items] | ||
Weighted Average Useful Life (Years) | 15 years 10 months 24 days | |
Weighted Average | Customer relationships | ||
Finite-Lived Intangible Assets [Line Items] | ||
Weighted Average Useful Life (Years) | 6 years 6 months | |
Weighted Average | Trademarks | ||
Finite-Lived Intangible Assets [Line Items] | ||
Weighted Average Useful Life (Years) | 9 years 3 months 18 days |
Goodwill and Intangible Asset90
Goodwill and Intangible Assets, Net - Schedule of Definite-Lived Intangible Assets, Estimated Future Amortization Expense (Details) $ in Thousands | Dec. 31, 2017USD ($) |
Goodwill and Intangible Assets Disclosure [Abstract] | |
2,018 | $ 19,258 |
2,019 | 18,935 |
2,020 | 18,833 |
2,021 | 18,645 |
2,022 | 17,646 |
Thereafter | 133,894 |
Total | $ 227,211 |
Lines of Credit and Long Term91
Lines of Credit and Long Term Debt - Lines of Credit - Additional Information (Details) - Revolving Credit Facility | 12 Months Ended |
Dec. 31, 2017USD ($) | |
Trans Ova Genetics, LC | First National Bank of Omaha | |
Line of Credit Facility [Line Items] | |
Line of credit facility, maximum borrowing capacity | $ 5,000,000 |
Line of credit facility, interest rate at period end | 4.32% |
Line of credit outstanding | $ 0 |
Trans Ova Genetics, LC | First National Bank of Omaha | London Interbank Offered Rate (LIBOR) | |
Line of Credit Facility [Line Items] | |
Debt instrument, basis spread on variable rate | 2.95% |
Exemplar Genetics, LLC | American State Bank | |
Line of Credit Facility [Line Items] | |
Line of credit facility, maximum borrowing capacity | $ 700,000 |
Debt instrument, interest rate, stated percentage | 5.25% |
Line of credit outstanding | $ 233,000 |
Minimum | Trans Ova Genetics, LC | First National Bank of Omaha | |
Line of Credit Facility [Line Items] | |
Debt instrument, interest rate, stated percentage | 3.00% |
Lines of Credit and Long Term92
Lines of Credit and Long Term Debt - Components of Long Term Debt (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 |
Debt Instrument [Line Items] | ||
Long term debt | $ 8,037 | $ 7,948 |
Less current portion | 502 | 386 |
Long term debt, less current portion | 7,535 | 7,562 |
Notes payable | ||
Debt Instrument [Line Items] | ||
Long term debt | 5,010 | 5,453 |
Royalty-based financing | ||
Debt Instrument [Line Items] | ||
Long term debt | 2,132 | 1,896 |
Other | ||
Debt Instrument [Line Items] | ||
Long term debt | $ 895 | $ 599 |
Lines of Credit and Long Term93
Lines of Credit and Long Term Debt - Long Term Debt - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Mar. 31, 2013 | |
Debt Instrument [Line Items] | |||
Long term debt | $ 8,037 | $ 7,948 | |
Notes payable to banks | Trans Ova Genetics, LC | American State Bank | |||
Debt Instrument [Line Items] | |||
Long term debt | 4,872 | ||
Debt instrument, periodic payment | $ 39 | ||
Debt instrument, interest rate, stated percentage | 3.95% | ||
Notes payable | |||
Debt Instrument [Line Items] | |||
Long term debt | $ 5,010 | 5,453 | |
Other | |||
Debt Instrument [Line Items] | |||
Long term debt | 895 | 599 | |
Royalty-based financing | |||
Debt Instrument [Line Items] | |||
Long term debt | 2,132 | $ 1,896 | |
Royalty-based financing | AquaBounty Technologies, Inc. | Atlantic Canada Opportunities Agency | |||
Debt Instrument [Line Items] | |||
Long term debt | 2,132 | ||
Amount available under the grant for research and development | $ 2,288 | ||
Claims period | 5 years | ||
Royalty on products | 10.00% | ||
Amount claimed | $ 1,952 | ||
Long term debt | 1,107 | ||
Accreted difference between face value of amount drawn and acquisition date fair value | $ 845 |
Lines of Credit and Long Term94
Lines of Credit and Long Term Debt - Schedule of Future Maturities of Long Term Debt (Details) $ in Thousands | Dec. 31, 2017USD ($) |
Debt Disclosure [Abstract] | |
2,018 | $ 502 |
2,019 | 401 |
2,020 | 372 |
2,021 | 832 |
2,022 | 360 |
Thereafter | 3,438 |
Total | $ 5,905 |
Income Taxes - Components of Lo
Income Taxes - Components of Loss Before Income Taxes (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Income Tax [Line Items] | |||
Loss before income taxes | $ (129,700) | $ (194,151) | $ (86,978) |
Domestic | |||
Income Tax [Line Items] | |||
Loss before income taxes | (71,343) | (157,067) | (69,287) |
Foreign | |||
Income Tax [Line Items] | |||
Loss before income taxes | $ (58,357) | $ (37,084) | $ (17,691) |
Income Taxes - Components of In
Income Taxes - Components of Income Tax Expense (Benefit) (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
U.S. federal income taxes: | |||
Current | $ 27 | $ (17) | $ 22 |
Deferred | (523) | 1,396 | 1,732 |
Foreign income taxes: | |||
Current | (379) | (393) | (123) |
Deferred | (2,269) | (5,177) | (1,003) |
State income taxes: | |||
Deferred | 264 | 314 | 388 |
Total income tax expense (benefit) | $ (2,880) | $ (3,877) | $ 1,016 |
Income Taxes - Schedule of Effe
Income Taxes - Schedule of Effective Income Tax Rate Reconciliation (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Income Tax Disclosure [Abstract] | |||
Computed statutory income tax benefit | $ (44,098) | $ (66,011) | $ (29,573) |
State and provincial income tax benefit, net of federal income taxes | (3,294) | (7,905) | (3,157) |
Nondeductible stock based compensation | 4,147 | 3,321 | 3,182 |
Nondeductible officer compensation | 476 | 0 | 2,433 |
Gain on dividend distribution of AquaBounty common stock | 3,965 | 0 | 0 |
Impairment of goodwill | 4,700 | 0 | 0 |
Research and development tax incentives | (1,166) | (6,350) | (348) |
Acquisition and internal restructuring transaction costs | 354 | 571 | 883 |
Provisional impact of the Tax Act | 85,288 | 0 | 0 |
Enacted changes in foreign tax rates and foreign tax reforms | 2,138 | 0 | (961) |
U.S.-foreign rate differential | 5,410 | 3,463 | 620 |
Other, net | (64) | 1,485 | (98) |
Income tax reconciliation income tax benefit before valuation allowance, total | 57,856 | (71,426) | (27,019) |
Change in valuation allowance for deferred tax assets | (60,736) | 67,549 | 28,035 |
Total income tax expense (benefit) | $ (2,880) | $ (3,877) | $ 1,016 |
Income Taxes - Schedule of Defe
Income Taxes - Schedule of Deferred Tax Assets and Liabilities (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014 |
Deferred tax assets | ||||
Allowance for doubtful accounts | $ 1,300 | $ 1,676 | ||
Inventory | 489 | 447 | ||
Equity securities and investments in affiliates | 17,510 | 31,729 | ||
Accrued liabilities and long-term debt | 3,131 | 4,168 | ||
Stock-based compensation | 26,936 | 8,460 | ||
Deferred revenue | 61,785 | 68,056 | ||
Research and development tax credits | 11,385 | 10,396 | ||
Net operating and capital loss carryforwards | 111,453 | 144,502 | ||
Total deferred tax assets | 233,989 | 269,434 | ||
Less: Valuation allowance | 215,582 | 256,165 | $ 190,174 | $ 161,660 |
Net deferred tax assets | 18,407 | 13,269 | ||
Deferred tax liabilities | ||||
Property, plant and equipment | 237 | 406 | ||
Intangible assets | 33,790 | 29,870 | ||
Total deferred tax liabilities | 34,027 | 30,276 | ||
Net deferred tax liabilities | $ (15,620) | $ (17,007) |
Income Taxes - Summary of Valua
Income Taxes - Summary of Valuation Allowance (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Valuation Allowance | |||
Valuation allowance at beginning of year | $ 256,165 | $ 190,174 | $ 161,660 |
Mergers and acquisitions, net | 0 | (1,416) | 1,228 |
Current year operations | 26,619 | 67,549 | 28,035 |
Adoption of ASU 2016-09 | 17,843 | 0 | 0 |
Provisional impact of the Tax Act | (87,473) | 0 | 0 |
Changes in foreign tax rates and foreign tax reforms | 1,327 | 0 | 0 |
Foreign currency translation adjustment | 1,101 | (142) | (749) |
Valuation allowance at end of year | $ 215,582 | $ 256,165 | $ 190,174 |
Income Taxes - Additional Infor
Income Taxes - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended | |||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2013 | |
Operating Loss Carryforwards [Line Items] | ||||
Federal corporate income tax rate | 34.00% | 34.00% | 34.00% | |
Federal and state research and development tax credits | $ 11,385 | $ 10,396 | ||
Retained earnings (accumulated deficit) | (847,820) | (729,341) | ||
Estimated tax benefit upon enactment of Tax Act | 2,185 | |||
Change in deferred tax assets resulting from enactment of Tax Act | 87,473 | |||
Estimated tax benefit due to changes in deferred tax liabilities upon enactment of Tax Act | 1,730 | |||
Estimated current tax benefit upon enactment of Tax Act | 455 | |||
Provisional transition tax amount | 0 | |||
Additional deferred tax liabilities recorded due to enacted foreign tax changes | 15,620 | $ 17,007 | ||
AquaBounty Technologies, Inc. | ||||
Operating Loss Carryforwards [Line Items] | ||||
Annual usage limit of operating loss carryforwards | $ 900 | |||
Expiration date of Federal income tax loss carryforwards | 2,018 | |||
Ownership percentage in AquaBounty (more than) | 50.00% | |||
Foreign Subsidiaries | ||||
Operating Loss Carryforwards [Line Items] | ||||
Retained earnings (accumulated deficit) | $ 65,052 | |||
Domestic | ||||
Operating Loss Carryforwards [Line Items] | ||||
Net operating losses inherited via acquisition | 33,590 | |||
Operating loss carryforwards | 244,274 | |||
Federal and state research and development tax credits | $ 7,737 | |||
Expiration date of Federal income tax loss carryforwards | 2,022 | |||
Domestic | GenVec, Inc. | ||||
Operating Loss Carryforwards [Line Items] | ||||
Net operating losses inherited via acquisition | $ 13,376 | |||
Domestic | AquaBounty Technologies, Inc. | ||||
Operating Loss Carryforwards [Line Items] | ||||
Operating loss carryforwards | 28,209 | |||
Foreign | ||||
Operating Loss Carryforwards [Line Items] | ||||
Operating loss carryforwards | 151,423 | |||
Foreign | AquaBounty Technologies, Inc. | ||||
Operating Loss Carryforwards [Line Items] | ||||
Operating loss carryforwards | 15,653 | |||
Tax credit | 2,832 | |||
BELGIUM | ||||
Operating Loss Carryforwards [Line Items] | ||||
Additional deferred tax liabilities recorded due to enacted foreign tax changes | $ 2,307 |
Shareholders' Equity - Addition
Shareholders' Equity - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 12 Months Ended | |||||
Dec. 31, 2017 | Jan. 31, 2017 | Aug. 31, 2015 | Jun. 30, 2015 | Jan. 31, 2015 | Dec. 31, 2017 | Dec. 31, 2015 | |
Class of Stock [Line Items] | |||||||
Shares issued in public or private offerings, net of issuance costs, shares | 1,207,980 | 5,609,756 | 4,312,500 | ||||
Value of shares issued in public or private offerings | $ 13,686 | $ 218,193 | $ 110,041 | $ 13,686 | $ 328,234 | ||
Underwriting discounts and commissions | 11,500 | 6,086 | |||||
Capitalized offering expenses | $ 306 | $ 311 | |||||
Noncash dividend to shareholders | $ 0 | 172,419 | |||||
Affiliates Of Third Security | |||||||
Class of Stock [Line Items] | |||||||
Shares issued in public or private offerings, net of issuance costs, shares | 555,556 | ||||||
AquaBounty Technologies, Inc. | |||||||
Class of Stock [Line Items] | |||||||
Noncash dividend, shares | 1,776,557 | ||||||
Noncash dividend to shareholders | $ 22,385 | ||||||
ZIOPHARM Oncology, Inc. | |||||||
Class of Stock [Line Items] | |||||||
Noncash dividend, shares | 17,830,305 | ||||||
Realized investment gain | $ 81,401 | ||||||
Intrexon Stock Option Plans | |||||||
Class of Stock [Line Items] | |||||||
Adjustment due to dividend (in shares) | 46,766 | 312,795 | |||||
Adjustment due to dividend (in usd per share) | $ 31.11 | $ 25.40 |
Shareholders' Equity - Componen
Shareholders' Equity - Components of Accumulated Other Comprehensive Loss (Details) - USD ($) $ in Thousands | Dec. 31, 2017 | Dec. 31, 2016 |
Accumulated Other Comprehensive Income (Loss) [Line Items] | ||
Intrexon shareholders' equity | $ 533,631 | $ 560,237 |
Unrealized loss on investments | ||
Accumulated Other Comprehensive Income (Loss) [Line Items] | ||
Intrexon shareholders' equity | (2) | (89) |
Loss on foreign currency translation adjustments | ||
Accumulated Other Comprehensive Income (Loss) [Line Items] | ||
Intrexon shareholders' equity | (15,552) | (36,113) |
Total accumulated other comprehensive loss | ||
Accumulated Other Comprehensive Income (Loss) [Line Items] | ||
Intrexon shareholders' equity | $ (15,554) | $ (36,202) |
Share-Based Payments - Schedule
Share-Based Payments - Schedule of Stock-based Compensation Expense (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | |||
Stock-based compensation cost | $ 41,576 | $ 42,202 | $ 38,667 |
Cost of products | |||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | |||
Stock-based compensation cost | 116 | 81 | 95 |
Cost of services | |||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | |||
Stock-based compensation cost | 322 | 274 | 354 |
Research and development | |||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | |||
Stock-based compensation cost | 9,336 | 9,251 | 8,614 |
Selling, general and administrative | |||
Share-based Compensation Arrangement by Share-based Payment Award, Compensation Cost [Line Items] | |||
Stock-based compensation cost | $ 31,802 | $ 32,596 | $ 29,604 |
Share-Based Payments - Addition
Share-Based Payments - Additional Information (Details) - USD ($) $ / shares in Units, $ in Thousands | 1 Months Ended | 12 Months Ended | |||||
Nov. 30, 2015 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Mar. 31, 2016 | Dec. 31, 2014 | Aug. 31, 2013 | |
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||||
Shares issued as payment for services | $ 11,118 | $ 10,777 | $ 2,169 | ||||
Intrexon Stock Option Plan - 2008 Plan | |||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||||
Remaining shares available to grant (in shares) | 0 | ||||||
Options outstanding (in shares) | 453,371 | ||||||
Intrexon Stock Option Plan - 2013 Plan | |||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||||
Remaining shares available to grant (in shares) | 4,747,496 | ||||||
Options outstanding (in shares) | 10,929,376 | ||||||
Number of authorized awards (in shares) | 18,000,000 | ||||||
Intrexon Stock Option Plans | |||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||||
Options outstanding (in shares) | 11,382,747 | 11,640,383 | 11,043,528 | 8,323,544 | |||
Term at issuance of option | 10 years | ||||||
Vesting period of option | 4 years | ||||||
Unrecognized compensation costs related to unvested awards | $ 68,999 | ||||||
Recognized over weighted-average period | 2 years | ||||||
Weighted average grant date fair value of options granted (in usd per share) | $ 12.19 | $ 16.28 | $ 25.96 | ||||
Aggregate intrinsic value of options exercised | $ 2,429 | $ 22,704 | $ 24,675 | ||||
Options outstanding, weighted average exercise price (in usd per share) | $ 28.99 | $ 31.25 | $ 32.66 | $ 22.59 | |||
Options exercisable (in shares) | 5,306,697 | ||||||
Aqua Bounty 2006 Stock Option Plan | |||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||||
Remaining shares available to grant (in shares) | 0 | ||||||
Aqua Bounty Stock Option Plans | |||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||||
Options outstanding (in shares) | 227,203 | 185,591 | |||||
Options outstanding, weighted average exercise price (in usd per share) | $ 9.39 | $ 7.89 | |||||
Options exercisable (in shares) | 192,748 | 181,766 | |||||
Chief Executive Officer | |||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||||
Monthly base salary | $ 200 | ||||||
Lock-up period | 3 years | ||||||
Term of compensation arrangement | 12 months | ||||||
Selling, general and administrative | Chief Executive Officer | |||||||
Share-based Compensation Arrangement by Share-based Payment Award [Line Items] | |||||||
Shares issued as payment for services | $ 1,908 | $ 1,861 | $ 314 |
Share-Based Payments - Intrexon
Share-Based Payments - Intrexon Stock Option Plans - Schedule of Stock Option Activity (Details) - Intrexon Stock Option Plans - $ / shares | 12 Months Ended | |||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014 | |
Number of Shares | ||||
Balances at beginning of period (in shares) | 11,640,383 | 11,043,528 | 8,323,544 | |
Granted (in shares) | 3,920,950 | 4,644,860 | 5,051,500 | |
Adjustment due to dividend (in shares) | 46,766 | 312,795 | ||
Exercised (in shares) | (149,429) | (1,210,840) | (1,029,291) | |
Forfeited (in shares) | (3,797,105) | (2,760,809) | (1,610,335) | |
Expired (in shares) | (278,818) | (76,356) | (4,685) | |
Balances at period end (in shares) | 11,382,747 | 11,640,383 | 11,043,528 | 8,323,544 |
Weighted Average Exercise Price (usd per share) | ||||
Balances at beginning of period (in usd per share) | $ 31.25 | $ 32.66 | $ 22.59 | |
Granted (in usd per share) | 21.47 | 29.39 | 45.82 | |
Adjustment due to dividend (in usd per share) | 31.11 | 25.40 | ||
Exercised (in usd per share) | (6.37) | (15.83) | (15.16) | |
Forfeited (in usd per share) | (28.37) | (40.34) | (26.75) | |
Expired (in usd per share) | (33.18) | (37.81) | (28.29) | |
Balances at period end (in usd per share) | $ 28.99 | 31.25 | $ 32.66 | $ 22.59 |
Additional Disclosures | ||||
Exercisable at period end (in shares) | 5,306,697 | |||
Options exercisable, weighted average exercise price (in usd per share) | $ 29.96 | $ 28.09 | ||
Balances at period end, weighted average remaining contractual period | 7 years 3 months 25 days | 8 years 2 months 15 days | 8 years 5 months 27 days | 8 years 7 months 21 days |
Exercisable at period end, weighted average remaining contractual period | 6 years 1 month 20 days |
Share-Based Payments - Intre106
Share-Based Payments - Intrexon Stock Option Plans - Summary of Information About Stock Options Outstanding (Details) - Intrexon Stock Option Plans - USD ($) $ / shares in Units, $ in Thousands | 12 Months Ended | |||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | Dec. 31, 2014 | |
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items] | ||||
Options outstanding, number of options (in shares) | 11,382,747 | 11,640,383 | ||
Options outstanding, weighted average exercise price (in usd per share) | $ 28.99 | $ 31.25 | $ 32.66 | $ 22.59 |
Options outstanding, weighted average remaining life (in years) | 7 years 3 months 25 days | 8 years 2 months 15 days | ||
Options outstanding, aggregate intrinsic value | $ 2,020 | $ 14,969 | ||
Options exercisable, number of options (in shares) | 5,306,697 | 3,418,035 | ||
Options exercisable, weighted average exercise price (in usd per share) | $ 29.96 | $ 28.09 | ||
Options exercisable, weighted average remaining life (in years) | 6 years 1 month 20 days | 6 years 10 months 17 days | ||
Options exercisable, aggregate intrinsic value | $ 2,020 | $ 11,852 | ||
Price range 1 | ||||
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items] | ||||
Stock options, exercise price range, lower limit (in usd per share) | $ 2.64 | $ 2.65 | ||
Stock options, exercise price range, upper limit (in usd per share) | $ 9.30 | $ 9.34 | ||
Options outstanding, number of options (in shares) | 453,371 | 562,951 | ||
Options outstanding, weighted average exercise price (in usd per share) | $ 7.06 | $ 6.23 | ||
Options outstanding, weighted average remaining life (in years) | 3 years 11 months 10 days | 4 years 1 month 18 days | ||
Options outstanding, aggregate intrinsic value | $ 2,020 | $ 10,172 | ||
Options exercisable, number of options (in shares) | 453,371 | 525,755 | ||
Options exercisable, weighted average exercise price (in usd per share) | $ 7.06 | $ 6.01 | ||
Options exercisable, weighted average remaining life (in years) | 3 years 11 months 10 days | 3 years 11 months 20 days | ||
Options exercisable, aggregate intrinsic value | $ 2,020 | $ 9,615 | ||
Price range 2 | ||||
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items] | ||||
Stock options, exercise price range, lower limit (in usd per share) | $ 12.50 | $ 15.21 | ||
Stock options, exercise price range, upper limit (in usd per share) | $ 21.38 | $ 27.19 | ||
Options outstanding, number of options (in shares) | 3,158,121 | 2,785,705 | ||
Options outstanding, weighted average exercise price (in usd per share) | $ 20.58 | $ 23.47 | ||
Options outstanding, weighted average remaining life (in years) | 8 years 8 months 25 days | 8 years 5 months 45 days | ||
Options outstanding, aggregate intrinsic value | $ 0 | $ 4,797 | ||
Options exercisable, number of options (in shares) | 456,942 | 684,704 | ||
Options exercisable, weighted average exercise price (in usd per share) | $ 19.52 | $ 21.07 | ||
Options exercisable, weighted average remaining life (in years) | 7 years 1 month 18 days | 7 years 3 months 15 days | ||
Options exercisable, aggregate intrinsic value | $ 0 | $ 2,237 | ||
Price range 3 | ||||
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items] | ||||
Stock options, exercise price range, lower limit (in usd per share) | $ 21.43 | $ 27.21 | ||
Stock options, exercise price range, upper limit (in usd per share) | $ 28.81 | $ 29.68 | ||
Options outstanding, number of options (in shares) | 3,399,721 | 3,147,242 | ||
Options outstanding, weighted average exercise price (in usd per share) | $ 25.55 | $ 29.30 | ||
Options outstanding, weighted average remaining life (in years) | 6 years 10 months 28 days | 7 years 5 months 42 days | ||
Options outstanding, aggregate intrinsic value | $ 0 | $ 0 | ||
Options exercisable, number of options (in shares) | 1,804,401 | 1,400,707 | ||
Options exercisable, weighted average exercise price (in usd per share) | $ 25.86 | $ 29.35 | ||
Options exercisable, weighted average remaining life (in years) | 5 years 7 months 38 days | 7 years 3 months 22 days | ||
Options exercisable, aggregate intrinsic value | $ 0 | $ 0 | ||
Price range 4 | ||||
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items] | ||||
Stock options, exercise price range, lower limit (in usd per share) | $ 28.88 | $ 29.70 | ||
Stock options, exercise price range, upper limit (in usd per share) | $ 40.99 | $ 42.22 | ||
Options outstanding, number of options (in shares) | 2,751,716 | 3,590,423 | ||
Options outstanding, weighted average exercise price (in usd per share) | $ 32.07 | $ 32.89 | ||
Options outstanding, weighted average remaining life (in years) | 6 years 8 months 12 days | 9 years 33 days | ||
Options outstanding, aggregate intrinsic value | $ 0 | $ 0 | ||
Options exercisable, number of options (in shares) | 1,732,250 | 345,274 | ||
Options exercisable, weighted average exercise price (in usd per share) | $ 31.51 | $ 37.06 | ||
Options exercisable, weighted average remaining life (in years) | 6 years 3 months 25 days | 6 years 10 months 6 days | ||
Options exercisable, aggregate intrinsic value | $ 0 | $ 0 | ||
Price range 5 | ||||
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items] | ||||
Stock options, exercise price range, lower limit (in usd per share) | $ 41.41 | $ 43.99 | ||
Stock options, exercise price range, upper limit (in usd per share) | $ 65.08 | $ 65.34 | ||
Options outstanding, number of options (in shares) | 1,619,818 | 1,554,062 | ||
Options outstanding, weighted average exercise price (in usd per share) | $ 53.52 | $ 54.40 | ||
Options outstanding, weighted average remaining life (in years) | 7 years 5 months 2 days | 8 years 4 months 35 days | ||
Options outstanding, aggregate intrinsic value | $ 0 | $ 0 | ||
Options exercisable, number of options (in shares) | 859,733 | 461,595 | ||
Options exercisable, weighted average exercise price (in usd per share) | $ 53.07 | $ 53.06 | ||
Options exercisable, weighted average remaining life (in years) | 7 years 4 months 18 days | 8 years 3 months 30 days | ||
Options exercisable, aggregate intrinsic value | $ 0 | $ 0 |
License Agreement - Additional
License Agreement - Additional Information (Details) | 1 Months Ended |
Jan. 31, 2015USD ($)shares | |
Other Commitments [Line Items] | |
Shares issued as consideration for licensing agreement, shares | shares | 2,100,085 |
Research and development | |
Other Commitments [Line Items] | |
Payment of license fees | $ 59,579,000 |
ZIOPHARM Oncology, Inc. | |
Other Commitments [Line Items] | |
Annual funding commitment, term | 3 years |
Minimum | ZIOPHARM Oncology, Inc. | |
Other Commitments [Line Items] | |
Annual funding commitment, amount | $ 15,000,000 |
Maximum | ZIOPHARM Oncology, Inc. | |
Other Commitments [Line Items] | |
Annual funding commitment, amount | $ 20,000,000 |
Commitments and Contingencies -
Commitments and Contingencies - Future Minimum Lease Payments Under Noncancelable Operating Leases (Details) $ in Thousands | Dec. 31, 2017USD ($) |
Commitments and Contingencies Disclosure [Abstract] | |
2,018 | $ 7,964 |
2,019 | 9,115 |
2,020 | 9,186 |
2,021 | 8,299 |
2,022 | 7,279 |
Thereafter | 26,044 |
Future minimum lease payments under operating leases, total | $ 67,887 |
Commitments and Contingencie109
Commitments and Contingencies - Operating Leases - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Leases [Abstract] | |||
Rent expense, including other facility expenses | $ 11,064 | $ 8,593 | $ 8,610 |
Rental income under sublease agreement | 137 | $ 1,051 | $ 1,486 |
Expected future rental income under sublease agreement, 2018 | 104 | ||
Expected future rental income under sublease agreement, 2019 | 120 | ||
Expected future rental income under sublease agreement, 2020 | 55 | ||
Expected future rental income under sublease agreement, 2021 | 56 | ||
Expected future rental income under sublease agreement, 2022 | 58 | ||
Expected future rental income under sublease agreement, thereafter | $ 310 |
Commitments and Contingencie110
Commitments and Contingencies - Purchase Commitments (Details) $ in Thousands | Dec. 31, 2017USD ($) |
Commitments and Contingencies Disclosure [Abstract] | |
Outstanding contractual purchase commitments | $ 15,802 |
Commitments and Contingencie111
Commitments and Contingencies - Additional Information (Details) $ in Thousands | 1 Months Ended | 2 Months Ended | 12 Months Ended | 50 Months Ended | ||||
Mar. 31, 2017claim | Jul. 31, 2016claim | May 31, 2016claim | Apr. 30, 2016USD ($) | Jul. 31, 2016claim | Dec. 31, 2017claim | Dec. 31, 2016USD ($) | Apr. 30, 2016USD ($) | |
Licensing and patent infringement suit | ||||||||
Loss Contingencies [Line Items] | ||||||||
Damages awarded to TransOva | $ | $ 528 | |||||||
Cumulative payments for royalties | $ | $ 3,170 | |||||||
Royalty payments not yet deposited | $ | 2,759 | $ 2,759 | ||||||
Hoffman v Intrexon Corporation et al. and Gibrall v. Intrexon Corporation et al. | ||||||||
Loss Contingencies [Line Items] | ||||||||
Number of lawsuits | 2 | |||||||
Shareholder demand regarding Third Security Services Agreement and CEO Compensation | ||||||||
Loss Contingencies [Line Items] | ||||||||
Number of similar lawsuits | 2 | |||||||
Shareholder demand regarding allegations made by Seeking Alpha financial blog | ||||||||
Loss Contingencies [Line Items] | ||||||||
Number of lawsuits | 1 | 2 | ||||||
XY, LLC | Licensing and patent infringement suit | ||||||||
Loss Contingencies [Line Items] | ||||||||
Damages awarded against TransOva | $ | $ 6,066 | |||||||
Claims dismissed | 9 | |||||||
Total claims | 12 | |||||||
Claims pending resolution | 3 | |||||||
Selling, general and administrative | Licensing and patent infringement suit | ||||||||
Loss Contingencies [Line Items] | ||||||||
Litigation settlement expense | $ | $ 4,228 |
Related Party Transactions - Ad
Related Party Transactions - Additional Information (Details) | Jan. 19, 2018 | Apr. 24, 2017 | Mar. 10, 2017 | Dec. 31, 2017USD ($) | Oct. 31, 2017USD ($) | Dec. 31, 2016USD ($) | Jun. 30, 2016$ / sharesshares | Nov. 30, 2015USD ($) | Jul. 31, 2015$ / sharesshares | Mar. 31, 2015USD ($)shares | Feb. 28, 2015USD ($) | Dec. 31, 2017USD ($)shares | Dec. 31, 2016USD ($)shares | Dec. 31, 2015USD ($)shares |
Related Party Transaction [Line Items] | ||||||||||||||
Sublease rental income | $ 137,000 | $ 1,051,000 | $ 1,486,000 | |||||||||||
Purchases of property and equipment | 46,666,000 | 31,629,000 | 12,749,000 | |||||||||||
Shares issued as payment for services | 11,118,000 | 10,777,000 | 2,169,000 | |||||||||||
Fair value of assets | $ 183,173,000 | $ 335,307,000 | 183,173,000 | 335,307,000 | ||||||||||
Purchase of preferred stock | 1,161,000 | 2,308,000 | 17,080,000 | |||||||||||
Other nonoperating income | 1,013,000 | 1,700,000 | 1,314,000 | |||||||||||
ZIOPHARM Oncology, Inc. | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Common stock purchased from collaborative partners, value | $ 12,600,000 | |||||||||||||
AmpliPhi Biosciences Corp | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Common stock purchased from collaborative partners, shares | shares | 27,879 | |||||||||||||
Warrants purchased from collaborative partners, shares | shares | 6,969 | |||||||||||||
Purchase of preferred stock | $ 2,300,000 | |||||||||||||
Oragenics, Inc. | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Common stock purchased from collaborative partners, shares | shares | 226,142 | |||||||||||||
Price per share of common shares (in usd per share) | $ / shares | $ 5.20 | |||||||||||||
Intrexon Energy Partners, LLC | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Purchases of property and equipment | 2,812,000 | |||||||||||||
Third Security | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Expense for services | 409,000 | 309,000 | 428,000 | |||||||||||
Sublease rental income | $ 43,000 | $ 43,000 | $ 43,000 | |||||||||||
Services agreement, term | 1 year | |||||||||||||
Shares issued as compensation for services, shares | shares | 500,650 | 337,163 | 48,678 | |||||||||||
Shares issued as payment for services | $ 8,704,000 | $ 8,571,000 | $ 1,375,000 | |||||||||||
Harvest Intrexon Enterprise Fund I, LP | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Other nonoperating income | 1,839,000 | 2,483,000 | $ 1,349,000 | |||||||||||
Fibrocell Science, Inc. | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Common stock purchased from collaborative partners, shares | shares | 125,290 | |||||||||||||
Price per share of common shares (in usd per share) | $ / shares | $ 17.4 | |||||||||||||
Series A Preferred Shares | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Convertible Preferred Shares, Conversion Price, Consecutive Trading Days | 20 days | |||||||||||||
Series A Preferred Shares | Affiliates Of Third Security | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Convertible Preferred Stock, Amount Authorized | $ 100,000,000 | |||||||||||||
Preferred stock, dividend rate, percentage | 8.00% | |||||||||||||
Common Stock | Third Security | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Expense for services | $ 800,000 | |||||||||||||
Warrants | AmpliPhi Biosciences Corp | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Purchase of preferred stock | 321,000 | |||||||||||||
Common Stock | AmpliPhi Biosciences Corp | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Purchase of preferred stock | $ 1,979,000 | |||||||||||||
Other assets | Convertible note and warrants | Fibrocell Science, Inc. | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Fair value of assets | $ 575,000 | 1,642,000 | $ 575,000 | $ 1,642,000 | ||||||||||
AmpliPhi Biosciences Corp | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Stockholders' equity, reverse stock split | 1-for-10 | |||||||||||||
Stockholders' equity reverse stock split conversion ratio | 0.1 | |||||||||||||
Fibrocell Science, Inc. | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Preferred stock, dividend rate, percentage | 4.00% | |||||||||||||
Stockholders' equity, reverse stock split | 1-for-3 | |||||||||||||
Stockholders' equity reverse stock split conversion ratio | 0.3333 | |||||||||||||
Third Security | Chief Executive Officer | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Ownership interest | 100.00% | 100.00% | ||||||||||||
AmpliPhi Biosciences Corp | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Realized investment (gain) loss | $ 4,098,000 | |||||||||||||
Subsequent Event | Oragenics, Inc. | ||||||||||||||
Related Party Transaction [Line Items] | ||||||||||||||
Stockholders' equity, reverse stock split | 1-for-10 | |||||||||||||
Stockholders' equity reverse stock split conversion ratio | 0.1 |
Net Loss per Share - Computatio
Net Loss per Share - Computation of Basic and Diluted Net Loss Per Share (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended | ||||||||||
Dec. 31, 2017 | [1] | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Numerator: | ||||||||||||
Net loss attributable to Intrexon | $ (27,266) | $ (39,689) | $ (18,664) | $ (31,399) | $ (44,137) | $ (28,982) | $ (49,064) | $ (64,429) | $ (117,018) | $ (186,612) | $ (84,493) | |
Denominator: | ||||||||||||
Weighted average shares outstanding, basic and diluted | 119,998,826 | 117,983,836 | 111,066,352 | |||||||||
Net loss attributable to Intrexon per share, basic and diluted | $ (0.23) | $ (0.33) | $ (0.16) | $ (0.26) | $ (0.37) | $ (0.24) | $ (0.42) | $ (0.55) | $ (0.98) | $ (1.58) | $ (0.76) | |
[1] | During the fourth quarter of 2017, the Company recognized the remaining balance of deferred revenue associated with ZIOPHARM ECC2 upon the parties' mutual agreement to terminate (Note 5). The Company also recorded goodwill impairment charges primarily related to the AquaBounty reporting unit and an impairment charge related to certain of its in-process research and development assets (Note 11). |
Net Loss per Share - Potentiall
Net Loss per Share - Potentially Dilutive Securities Excluded from Calculation of Net Loss per Share (Details) - shares | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | |||
Antidilutive securities excluded from computation of earnings per share, amount | 11,516,011 | 11,640,383 | 11,238,247 |
Options | |||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | |||
Antidilutive securities excluded from computation of earnings per share, amount | 11,382,747 | 11,640,383 | 11,043,528 |
Warrants | |||
Antidilutive Securities Excluded from Computation of Earnings Per Share [Line Items] | |||
Antidilutive securities excluded from computation of earnings per share, amount | 133,264 | 0 | 194,719 |
Quarterly Financial Informat115
Quarterly Financial Information (Unaudited) - Schedule of Quarterly Financial Information (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended | ||||||||||
Dec. 31, 2017 | [1] | Sep. 30, 2017 | Jun. 30, 2017 | Mar. 31, 2017 | Dec. 31, 2016 | Sep. 30, 2016 | Jun. 30, 2016 | Mar. 31, 2016 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Quarterly Financial Information Disclosure [Abstract] | ||||||||||||
Total revenues | $ 77,028 | $ 46,016 | $ 54,433 | $ 53,504 | $ 46,002 | $ 48,985 | $ 52,501 | $ 43,438 | $ 230,981 | $ 190,926 | $ 173,605 | |
Operating loss | (26,492) | (44,747) | (35,270) | (31,381) | (32,590) | (28,821) | (23,222) | (40,533) | (137,890) | (125,166) | (146,864) | |
Net loss | (33,945) | (40,836) | (19,662) | (32,377) | (44,912) | (30,011) | (50,031) | (65,320) | (126,820) | (190,274) | (87,994) | |
Net loss attributable to Intrexon | $ (27,266) | $ (39,689) | $ (18,664) | $ (31,399) | $ (44,137) | $ (28,982) | $ (49,064) | $ (64,429) | $ (117,018) | $ (186,612) | $ (84,493) | |
Net loss attributable to Intrexon per share, basic and diluted | $ (0.23) | $ (0.33) | $ (0.16) | $ (0.26) | $ (0.37) | $ (0.24) | $ (0.42) | $ (0.55) | $ (0.98) | $ (1.58) | $ (0.76) | |
[1] | During the fourth quarter of 2017, the Company recognized the remaining balance of deferred revenue associated with ZIOPHARM ECC2 upon the parties' mutual agreement to terminate (Note 5). The Company also recorded goodwill impairment charges primarily related to the AquaBounty reporting unit and an impairment charge related to certain of its in-process research and development assets (Note 11). |
Defined Contribution Plans - Ad
Defined Contribution Plans - Additional Information (Details) - USD ($) $ in Thousands | 12 Months Ended | ||
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Retirement Benefits [Abstract] | |||
Defined contribution plans, cost recognized | $ 2,367 | $ 1,857 | $ 1,157 |
Subsequent Events - Additional
Subsequent Events - Additional Information (Details) - USD ($) $ in Thousands | 1 Months Ended | 2 Months Ended | 12 Months Ended | ||||||
Jan. 31, 2018 | Dec. 31, 2017 | Jan. 31, 2017 | Aug. 31, 2015 | Jan. 31, 2015 | Mar. 01, 2018 | Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015 | |
Subsequent Event [Line Items] | |||||||||
Shares issued in public offering | 1,207,980 | 5,609,756 | 4,312,500 | ||||||
Proceeds from shares issued in public offering | $ 0 | $ 0 | $ 328,234 | ||||||
Underwriting discounts and commissions | $ 11,500 | $ 6,086 | |||||||
Capitalized offering expenses | $ 306 | $ 311 | |||||||
Collaboration and licensing revenues | $ 145,579 | 109,871 | $ 87,821 | ||||||
Subsequent Event | |||||||||
Subsequent Event [Line Items] | |||||||||
Proceeds from shares issued in public offering | $ 82,242 | ||||||||
Underwriting discounts and commissions | 3,688 | ||||||||
Capitalized offering expenses | 320 | ||||||||
Affiliates Of Third Security | |||||||||
Subsequent Event [Line Items] | |||||||||
Shares issued in public offering | 555,556 | ||||||||
AquaBounty Technologies, Inc. | |||||||||
Subsequent Event [Line Items] | |||||||||
Purchase of additional equity of majority-owned subsidiary | $ 25,000 | ||||||||
Parent ownership interest | 58.00% | 58.00% | |||||||
AquaBounty Technologies, Inc. | Subsequent Event | |||||||||
Subsequent Event [Line Items] | |||||||||
Purchase of additional equity of majority-owned subsidiary | $ 5,000 | ||||||||
Parent ownership interest | 53.00% | ||||||||
Common Stock | |||||||||
Subsequent Event [Line Items] | |||||||||
Shares issued in public offering | 1,207,980 | 9,922,256 | |||||||
Common Stock | Subsequent Event | |||||||||
Subsequent Event [Line Items] | |||||||||
Shares issued in public offering | 6,900,000 | ||||||||
Common Stock | Affiliates Of Third Security | Subsequent Event | |||||||||
Subsequent Event [Line Items] | |||||||||
Shares issued in public offering | 1,000,000 | ||||||||
Upfront and Milestone Payments | |||||||||
Subsequent Event [Line Items] | |||||||||
Collaboration and licensing revenues | $ 71,637 | $ 34,433 | $ 32,513 | ||||||
Upfront and Milestone Payments | Upfront | OvaScience, Inc. | Subsequent Event | |||||||||
Subsequent Event [Line Items] | |||||||||
Collaboration and licensing revenues | $ 3,183 |