Michael L. Penley (858) 550-6028 mpenley@cooley.com | VIA EDGAR AND FEDERAL EXPRESS |
June 16, 2010
United States Securities and Exchange Commission
Division of Corporation Finance
Mail Stop 4720
100 F Street, N.E.
Washington, D.C. 20549
Attn: | Jeffrey Riedler |
John Krug |
Daniel Greenspan |
Vanessa Robertson |
Joel Parker |
Re: | Trius Therapeutics, Inc. |
Registration Statement on Form S-1 (File No. 333-162945) |
Amendment No. 5 Filed June 16, 2010 |
Dear Ms. Robertson and Messrs. Riedler, Krug, Greenspan and Parker:
Enclosed for electronic filing via EDGAR pursuant to the Securities Act of 1933, as amended, on behalf of our client, Trius Therapeutics, Inc. (the“Company”), is Amendment No. 5 (“Amendment No. 5”) to the Company’s Registration Statement on Form S-1 (the“Registration Statement”) originally filed with the Securities and Exchange Commission (the“Commission”) on November 6, 2009. The copy of Amendment No. 5 enclosed herewith is marked to show changes to Amendment No. 4 to the Registration Statement filed with the Commission on February 25, 2010.
The Company respectfully requests the staff’s assistance in completing the review of the Registration Statement and Amendment No. 5 as soon as possible. Please advise us if we can provide any further information or assistance to facilitate your review. Please direct any further comments or questions regarding Amendment No. 5 to me at (858) 550-6028 or Charles J. Bair, Esq. at (858) 550-6142.
Sincerely,
Cooley LLP
/s/ Michael L. Penley, Esq.
cc: | Jeffrey Stein, Ph.D., Trius Therapeutics, Inc. |
John P. Schmid, Trius Therapeutics, Inc. |
M. Wainwright Fishburn, Jr., Esq., Cooley LLP |
Charles J. Bair, Esq., Cooley LLP |
Patrick A. Pohlen, Esq., Latham & Watkins LLP |
Cheston J. Larson, Esq., Latham & Watkins LLP |
Divakar Gupta, Esq., Latham & Watkins LLP |
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